Result of FASTA (omim) for pF1KB5633
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB5633, 522 aa
  1>>>pF1KB5633 522 - 522 aa - 522 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 6.6319+/-0.000454; mu= 14.3498+/- 0.028
 mean_var=205.3279+/-45.036, 0's: 0 Z-trim(115.0): 140  B-trim: 0 in 0/54
 Lambda= 0.089506
 statistics sampled from 24975 (25132) to 24975 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.649), E-opt: 0.2 (0.295), width:  16
 Scan time:  9.320

The best scores are:                                      opt bits E(85289)
NP_004611 (OMIM: 602355) TNF receptor-associated f ( 522) 3654 485.3 1.9e-136
NP_665802 (OMIM: 602355) TNF receptor-associated f ( 522) 3654 485.3 1.9e-136
XP_016873709 (OMIM: 602355) PREDICTED: TNF recepto ( 324) 1444 199.6 1.2e-50
NP_004286 (OMIM: 602464) TNF receptor-associated f ( 470)  641 96.1 2.4e-19
XP_011535420 (OMIM: 601896,614849) PREDICTED: TNF  ( 485)  625 94.1   1e-18
NP_001186356 (OMIM: 601896,614849) TNF receptor-as ( 485)  625 94.1   1e-18
NP_663777 (OMIM: 601896,614849) TNF receptor-assoc ( 568)  504 78.6 5.6e-14
XP_016877107 (OMIM: 601896,614849) PREDICTED: TNF  ( 568)  504 78.6 5.6e-14
XP_016877106 (OMIM: 601896,614849) PREDICTED: TNF  ( 568)  504 78.6 5.6e-14
NP_003291 (OMIM: 601896,614849) TNF receptor-assoc ( 568)  504 78.6 5.6e-14
NP_001029082 (OMIM: 602356) TNF receptor-associate ( 557)  498 77.8 9.5e-14
XP_016857710 (OMIM: 602356) PREDICTED: TNF recepto ( 557)  498 77.8 9.5e-14
NP_665702 (OMIM: 602356) TNF receptor-associated f ( 557)  498 77.8 9.5e-14
NP_004610 (OMIM: 602356) TNF receptor-associated f ( 557)  498 77.8 9.5e-14
XP_016877109 (OMIM: 601896,614849) PREDICTED: TNF  ( 292)  486 75.9 1.9e-13
NP_663778 (OMIM: 601896,614849) TNF receptor-assoc ( 543)  411 66.5 2.3e-10
XP_016877108 (OMIM: 601896,614849) PREDICTED: TNF  ( 543)  411 66.5 2.3e-10
XP_011535419 (OMIM: 601896,614849) PREDICTED: TNF  ( 512)  401 65.2 5.3e-10
XP_016870584 (OMIM: 601895) PREDICTED: TNF recepto ( 501)  399 64.9 6.3e-10
XP_011517280 (OMIM: 601895) PREDICTED: TNF recepto ( 501)  399 64.9 6.3e-10
XP_011517279 (OMIM: 601895) PREDICTED: TNF recepto ( 501)  399 64.9 6.3e-10
XP_011517277 (OMIM: 601895) PREDICTED: TNF recepto ( 501)  399 64.9 6.3e-10
XP_011517276 (OMIM: 601895) PREDICTED: TNF recepto ( 501)  399 64.9 6.3e-10
XP_011517278 (OMIM: 601895) PREDICTED: TNF recepto ( 501)  399 64.9 6.3e-10
NP_066961 (OMIM: 601895) TNF receptor-associated f ( 501)  399 64.9 6.3e-10
XP_016870583 (OMIM: 601895) PREDICTED: TNF recepto ( 533)  399 65.0 6.5e-10
XP_011517275 (OMIM: 601895) PREDICTED: TNF recepto ( 556)  399 65.0 6.7e-10
NP_001177876 (OMIM: 601711) TNF receptor-associate ( 294)  373 61.3 4.7e-09
NP_005649 (OMIM: 601711) TNF receptor-associated f ( 416)  373 61.5 5.8e-09
NP_001177874 (OMIM: 601711) TNF receptor-associate ( 416)  373 61.5 5.8e-09
XP_011535418 (OMIM: 601896,614849) PREDICTED: TNF  ( 516)  366 60.7 1.2e-08
XP_011508261 (OMIM: 602356) PREDICTED: TNF recepto ( 568)  290 50.9 1.2e-05
NP_001306136 (OMIM: 602356) TNF receptor-associate ( 568)  290 50.9 1.2e-05
XP_011508262 (OMIM: 602356) PREDICTED: TNF recepto ( 568)  290 50.9 1.2e-05
XP_011508259 (OMIM: 602356) PREDICTED: TNF recepto ( 631)  284 50.2 2.1e-05
XP_011523808 (OMIM: 602464) PREDICTED: TNF recepto ( 454)  274 48.7 4.3e-05
XP_011523807 (OMIM: 602464) PREDICTED: TNF recepto ( 461)  274 48.7 4.3e-05
XP_011523806 (OMIM: 602464) PREDICTED: TNF recepto ( 477)  274 48.8 4.4e-05
XP_011523810 (OMIM: 602464) PREDICTED: TNF recepto ( 352)  268 47.8 6.3e-05
XP_011523809 (OMIM: 602464) PREDICTED: TNF recepto ( 352)  268 47.8 6.3e-05
XP_016861431 (OMIM: 609729) PREDICTED: E3 ubiquiti (1037)  253 46.5 0.00046
NP_055824 (OMIM: 609729) E3 ubiquitin-protein liga (1066)  253 46.5 0.00047
NP_001158067 (OMIM: 609730) PDZ domain-containing  (1036)  220 42.2  0.0088


>>NP_004611 (OMIM: 602355) TNF receptor-associated facto  (522 aa)
 initn: 3654 init1: 3654 opt: 3654  Z-score: 2570.6  bits: 485.3 E(85289): 1.9e-136
Smith-Waterman score: 3654; 100.0% identity (100.0% similar) in 522 aa overlap (1-522:1-522)

               10        20        30        40        50        60
pF1KB5 MSLLNCENSCGSSQSESDCCVAMASSCSAVTKDDSVGGTASTGNLSSSFMEEIQGYDVEF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MSLLNCENSCGSSQSESDCCVAMASSCSAVTKDDSVGGTASTGNLSSSFMEEIQGYDVEF
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB5 DPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 DPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPD
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB5 NFAKREILSLMVKCPNEGCLHKMELRHLEDHQAHCEFALMDCPQCQRPFQKFHINIHILK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 NFAKREILSLMVKCPNEGCLHKMELRHLEDHQAHCEFALMDCPQCQRPFQKFHINIHILK
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB5 DCPRRQVSCDNCAASMAFEDKEIHDQNCPLANVICEYCNTILIREQMPNHYDLDCPTAPI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 DCPRRQVSCDNCAASMAFEDKEIHDQNCPLANVICEYCNTILIREQMPNHYDLDCPTAPI
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB5 PCTFSTFGCHEKMQRNHLARHLQENTQSHMRMLAQAVHSLSVIPDSGYISEVRNFQETIH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 PCTFSTFGCHEKMQRNHLARHLQENTQSHMRMLAQAVHSLSVIPDSGYISEVRNFQETIH
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB5 QLEGRLVRQDHQIRELTAKMETQSMYVSELKRTIRTLEDKVAEIEAQQCNGIYIWKIGNF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QLEGRLVRQDHQIRELTAKMETQSMYVSELKRTIRTLEDKVAEIEAQQCNGIYIWKIGNF
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB5 GMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDS
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB5 HLPWPFQGTIRLTILDQSEAPVRQNHEEIMDAKPELLAFQRPTIPRNPKGFGYVTFMHLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 HLPWPFQGTIRLTILDQSEAPVRQNHEEIMDAKPELLAFQRPTIPRNPKGFGYVTFMHLE
              430       440       450       460       470       480

              490       500       510       520  
pF1KB5 ALRQRTFIKDDTLLVRCEVSTRFDMGSLRREGFQPRSTDAGV
       ::::::::::::::::::::::::::::::::::::::::::
NP_004 ALRQRTFIKDDTLLVRCEVSTRFDMGSLRREGFQPRSTDAGV
              490       500       510       520  

>>NP_665802 (OMIM: 602355) TNF receptor-associated facto  (522 aa)
 initn: 3654 init1: 3654 opt: 3654  Z-score: 2570.6  bits: 485.3 E(85289): 1.9e-136
Smith-Waterman score: 3654; 100.0% identity (100.0% similar) in 522 aa overlap (1-522:1-522)

               10        20        30        40        50        60
pF1KB5 MSLLNCENSCGSSQSESDCCVAMASSCSAVTKDDSVGGTASTGNLSSSFMEEIQGYDVEF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_665 MSLLNCENSCGSSQSESDCCVAMASSCSAVTKDDSVGGTASTGNLSSSFMEEIQGYDVEF
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB5 DPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_665 DPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPD
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB5 NFAKREILSLMVKCPNEGCLHKMELRHLEDHQAHCEFALMDCPQCQRPFQKFHINIHILK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_665 NFAKREILSLMVKCPNEGCLHKMELRHLEDHQAHCEFALMDCPQCQRPFQKFHINIHILK
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB5 DCPRRQVSCDNCAASMAFEDKEIHDQNCPLANVICEYCNTILIREQMPNHYDLDCPTAPI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_665 DCPRRQVSCDNCAASMAFEDKEIHDQNCPLANVICEYCNTILIREQMPNHYDLDCPTAPI
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB5 PCTFSTFGCHEKMQRNHLARHLQENTQSHMRMLAQAVHSLSVIPDSGYISEVRNFQETIH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_665 PCTFSTFGCHEKMQRNHLARHLQENTQSHMRMLAQAVHSLSVIPDSGYISEVRNFQETIH
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB5 QLEGRLVRQDHQIRELTAKMETQSMYVSELKRTIRTLEDKVAEIEAQQCNGIYIWKIGNF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_665 QLEGRLVRQDHQIRELTAKMETQSMYVSELKRTIRTLEDKVAEIEAQQCNGIYIWKIGNF
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB5 GMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_665 GMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDS
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB5 HLPWPFQGTIRLTILDQSEAPVRQNHEEIMDAKPELLAFQRPTIPRNPKGFGYVTFMHLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_665 HLPWPFQGTIRLTILDQSEAPVRQNHEEIMDAKPELLAFQRPTIPRNPKGFGYVTFMHLE
              430       440       450       460       470       480

              490       500       510       520  
pF1KB5 ALRQRTFIKDDTLLVRCEVSTRFDMGSLRREGFQPRSTDAGV
       ::::::::::::::::::::::::::::::::::::::::::
NP_665 ALRQRTFIKDDTLLVRCEVSTRFDMGSLRREGFQPRSTDAGV
              490       500       510       520  

>>XP_016873709 (OMIM: 602355) PREDICTED: TNF receptor-as  (324 aa)
 initn: 1444 init1: 1444 opt: 1444  Z-score: 1030.5  bits: 199.6 E(85289): 1.2e-50
Smith-Waterman score: 1449; 84.7% identity (88.0% similar) in 249 aa overlap (1-249:1-232)

               10        20        30        40        50        60
pF1KB5 MSLLNCENSCGSSQSESDCCVAMASSCSAVTKDDSVGGTASTGNLSSSFMEEIQGYDVEF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSLLNCENSCGSSQSESDCCVAMASSCSAVTKDDSVGGTASTGNLSSSFMEEIQGYDVEF
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB5 DPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPD
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB5 NFAKREILSLMVKCPNEGCLHKMELRHLEDHQAHCEFALMDCPQCQRPFQKFHINIHILK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NFAKREILSLMVKCPNEGCLHKMELRHLEDHQAHCEFALMDCPQCQRPFQKFHINIHILK
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB5 DCPRRQVSCDNCAASMAFEDKEIHDQNCPLANVICEYCNTILIREQMPNHYDLDCPTAPI
       ::::::::::::::::::::::                .  :. .   . .::. :  : 
XP_016 DCPRRQVSCDNCAASMAFEDKE----------------SFTLVAQAGVQWHDLSSPQ-PQ
              190       200                       210       220    

              250       260       270       280       290       300
pF1KB5 PCTFSTFGCHEKMQRNHLARHLQENTQSHMRMLAQAVHSLSVIPDSGYISEVRNFQETIH
       :  :. :.:                                                   
XP_016 PPGFKRFSCLSLLSSWDYRHVPPCPANIFVFLVETRFLHVGQAGLELPTSGNPPALASQS
           230       240       250       260       270       280   

>>NP_004286 (OMIM: 602464) TNF receptor-associated facto  (470 aa)
 initn: 749 init1: 143 opt: 641  Z-score: 468.4  bits: 96.1 E(85289): 2.4e-19
Smith-Waterman score: 746; 26.7% identity (57.8% similar) in 469 aa overlap (53-499:1-462)

             30        40        50        60        70        80  
pF1KB5 MASSCSAVTKDDSVGGTASTGNLSSSFMEEIQGYDVEFDPPLESKYECPICLMALREAVQ
                                     . :.: .:    . .  ::.:   .:: ::
NP_004                               MPGFDYKFLEKPKRRLLCPLCGKPMREPVQ
                                             10        20        30

              90       100       110       120       130           
pF1KB5 -TPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREILSLMVKC--PNEGC
        . :::::: .:. . . ..  ::: :.  :   ...::   . ..:.: ..:   .:::
NP_004 VSTCGHRFCDTCLQEFLSEGVFKCPEDQLPLDYAKIYPDPELEVQVLGLPIRCIHSEEGC
               40        50        60        70        80        90

     140       150       160        170       180       190        
pF1KB5 LHKMELRHLEDHQAHCEFALMDCP-QCQRPFQKFHINIHILKDCPRRQVSCDNCAASMAF
         .  ::::. :   : : .. :: .:   ...  .  :. .:::.:...:. :. ... 
NP_004 RWSGPLRHLQGHLNTCSFNVIPCPNRCPMKLSRRDLPAHLQHDCPKRRLKCEFCGCDFSG
              100       110       120       130       140       150

      200       210        220       230       240       250       
pF1KB5 EDKEIHDQNCPLANVICEY-CNTILIREQMPNHYDLDCPTAPIPCTFSTFGCHEKMQRNH
       :  : :.  ::  .: ::  :.. ..:. . .:   .::    :::.    : ...  . 
NP_004 EAYESHEGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTY----CTKEFVFDT
              160       170       180       190           200      

       260       270        280       290                300       
pF1KB5 LARHLQENTQSHMRMLAQ-AVHSLSVIPDSGYISEVRN-------FQET--IHQLEGRLV
       .  :  .  .  .    : .: ...     :....  :       :...   :.   .:.
NP_004 IQSHQYQCPRLPVACPNQCGVGTVAREDLPGHLKDSCNTALVLCPFKDSGCKHRCP-KLA
        210       220       230       240       250       260      

       310       320       330       340       350       360       
pF1KB5 RQDHQIRELTAKMETQSMYVSELKRTIRTLEDKVAEIEAQQCNGIYIWKIGNFGMHLKCQ
          :  . .  ..  .   ::. .. .. :. .. :. . . .:. :::::..: .:.  
NP_004 MARHVEESVKPHLAMMCALVSRQRQELQELRRELEELSVGS-DGVLIWKIGSYGRRLQEA
         270       280       290       300        310       320    

       370       380       390       400       410       420       
pF1KB5 EEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQ
       . .  .   ::.::: : :::: .   :.  ...  ....::..... : .:. : ::: 
NP_004 KAKPNLECFSPAFYTHKYGYKLQVSAFLN-GNGSGEGTHLSLYIRVLPGAFDNLLEWPFA
          330       340       350        360       370       380   

       430       440         450       460            470       480
pF1KB5 GTIRLTILDQSEAPVR--QNHEEIMDAKPELLAFQRP-----TIPRNPKGFGYVTFMHLE
         . ...::::.  .   :.  : .   :.   ::.:     .. ..  ::::  :.  .
NP_004 RRVTFSLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDESSLGFGYPKFISHQ
           390       400       410       420       430       440   

              490       500       510       520  
pF1KB5 ALRQRTFIKDDTLLVRCEVSTRFDMGSLRREGFQPRSTDAGV
        .:.:....::....:  :                       
NP_004 DIRKRNYVRDDAVFIRAAVELPRKILS               
           450       460       470               

>>XP_011535420 (OMIM: 601896,614849) PREDICTED: TNF rece  (485 aa)
 initn: 506 init1: 242 opt: 625  Z-score: 457.1  bits: 94.1 E(85289): 1e-18
Smith-Waterman score: 645; 28.7% identity (58.7% similar) in 470 aa overlap (49-501:32-479)

       20        30        40        50        60        70        
pF1KB5 CCVAMASSCSAVTKDDSVGGTASTGNLSSSFMEEIQGYDVEFDPPLESKYECPICLMALR
                                     :. :  ::  .:   .:.::.:  : ..: 
XP_011 ESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLC
              10        20        30        40        50        60 

       80        90       100       110       120       130        
pF1KB5 EAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREILSLMVKCPNE-
          :: ::::::..:.   . ... :: . .: ......: ::  :::::.:.. : :: 
XP_011 SPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNES
              70        80        90       100       110       120 

        140       150        160         170       180       190   
pF1KB5 -GCLHKMELRHLEDH-QAHCEFALMDC--PQCQRPFQKFHINIHILKDCPRRQVSCDNCA
        :: ... : ::  : .  :.:  . :  :.:..   .  .  :. : :  :...:..: 
XP_011 RGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCK
             130       140       150       160       170       180 

           200       210       220       230       240       250   
pF1KB5 ASMAFEDKEIHDQNCPLANVICEYCNTILIREQMPNHYDLDCPTAPIPCTFSTFGCHEK-
       ... .    :  :   : :   :  ..:   ... :.           :.:     ..: 
XP_011 SQVPM----IALQVSLLQNESVEKNKSI---QSLHNQI----------CSFEIEIERQKE
                 190       200          210                 220    

            260            270       280         290       300     
pF1KB5 MQRNHLAR--HLQENTQSH---MRMLAQAVHSLSVIPD--SGYISEVRNFQETIHQLEGR
       : ::. ..  :::.  .:.   .. : . .. .    .  ... : :...:. . .::. 
XP_011 MLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELES-
          230       240       250       260       270       280    

         310       320        330          340       350       360 
pF1KB5 LVRQDHQIRELTAKMETQ-SMYVSELK-RTIRT--LEDKVAEIEAQQCNGIYIWKIGNFG
       . ..  :. . :. .:.: : . . :. . ::   .. .   .:. . ::. :::: .. 
XP_011 VDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYK
           290       300       310       320       330       340   

             370       380       390       400       410       420 
pF1KB5 MHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSH
        . .     : . ..:  ::::  :::.: :..:.     . ....:::   :.::::. 
XP_011 RRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMRGEYDAL
           350       360       370       380        390       400  

             430       440       450       460       470       480 
pF1KB5 LPWPFQGTIRLTILDQSEAPVRQNHEEIMDAKPELLAFQRPTIPRNPKGFGYVTFMHLEA
       :::::.  . : ..::. .  :..  . .   :.  .:..::   :  . :  .:.   .
XP_011 LPWPFKQKVTLMLMDQGSS--RRHLGDAFKPDPNSSSFKKPTGEMNIAS-GCPVFVAQTV
            410       420         430       440        450         

             490       500       510       520  
pF1KB5 LRQRTFIKDDTLLVRCEVSTRFDMGSLRREGFQPRSTDAGV
       :.. :.:::::....  :.:                     
XP_011 LENGTYIKDDTIFIKVIVDTSDLPDP               
     460       470       480                    

>>NP_001186356 (OMIM: 601896,614849) TNF receptor-associ  (485 aa)
 initn: 506 init1: 242 opt: 625  Z-score: 457.1  bits: 94.1 E(85289): 1e-18
Smith-Waterman score: 645; 28.7% identity (58.7% similar) in 470 aa overlap (49-501:32-479)

       20        30        40        50        60        70        
pF1KB5 CCVAMASSCSAVTKDDSVGGTASTGNLSSSFMEEIQGYDVEFDPPLESKYECPICLMALR
                                     :. :  ::  .:   .:.::.:  : ..: 
NP_001 ESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLC
              10        20        30        40        50        60 

       80        90       100       110       120       130        
pF1KB5 EAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREILSLMVKCPNE-
          :: ::::::..:.   . ... :: . .: ......: ::  :::::.:.. : :: 
NP_001 SPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNES
              70        80        90       100       110       120 

        140       150        160         170       180       190   
pF1KB5 -GCLHKMELRHLEDH-QAHCEFALMDC--PQCQRPFQKFHINIHILKDCPRRQVSCDNCA
        :: ... : ::  : .  :.:  . :  :.:..   .  .  :. : :  :...:..: 
NP_001 RGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCK
             130       140       150       160       170       180 

           200       210       220       230       240       250   
pF1KB5 ASMAFEDKEIHDQNCPLANVICEYCNTILIREQMPNHYDLDCPTAPIPCTFSTFGCHEK-
       ... .    :  :   : :   :  ..:   ... :.           :.:     ..: 
NP_001 SQVPM----IALQVSLLQNESVEKNKSI---QSLHNQI----------CSFEIEIERQKE
                 190       200          210                 220    

            260            270       280         290       300     
pF1KB5 MQRNHLAR--HLQENTQSH---MRMLAQAVHSLSVIPD--SGYISEVRNFQETIHQLEGR
       : ::. ..  :::.  .:.   .. : . .. .    .  ... : :...:. . .::. 
NP_001 MLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELES-
          230       240       250       260       270       280    

         310       320        330          340       350       360 
pF1KB5 LVRQDHQIRELTAKMETQ-SMYVSELK-RTIRT--LEDKVAEIEAQQCNGIYIWKIGNFG
       . ..  :. . :. .:.: : . . :. . ::   .. .   .:. . ::. :::: .. 
NP_001 VDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYK
           290       300       310       320       330       340   

             370       380       390       400       410       420 
pF1KB5 MHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSH
        . .     : . ..:  ::::  :::.: :..:.     . ....:::   :.::::. 
NP_001 RRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMRGEYDAL
           350       360       370       380        390       400  

             430       440       450       460       470       480 
pF1KB5 LPWPFQGTIRLTILDQSEAPVRQNHEEIMDAKPELLAFQRPTIPRNPKGFGYVTFMHLEA
       :::::.  . : ..::. .  :..  . .   :.  .:..::   :  . :  .:.   .
NP_001 LPWPFKQKVTLMLMDQGSS--RRHLGDAFKPDPNSSSFKKPTGEMNIAS-GCPVFVAQTV
            410       420         430       440        450         

             490       500       510       520  
pF1KB5 LRQRTFIKDDTLLVRCEVSTRFDMGSLRREGFQPRSTDAGV
       :.. :.:::::....  :.:                     
NP_001 LENGTYIKDDTIFIKVIVDTSDLPDP               
     460       470       480                    

>>NP_663777 (OMIM: 601896,614849) TNF receptor-associate  (568 aa)
 initn: 506 init1: 242 opt: 504  Z-score: 371.9  bits: 78.6 E(85289): 5.6e-14
Smith-Waterman score: 638; 26.3% identity (54.2% similar) in 498 aa overlap (49-463:32-525)

       20        30        40        50        60        70        
pF1KB5 CCVAMASSCSAVTKDDSVGGTASTGNLSSSFMEEIQGYDVEFDPPLESKYECPICLMALR
                                     :. :  ::  .:   .:.::.:  : ..: 
NP_663 ESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLC
              10        20        30        40        50        60 

       80        90       100       110       120       130        
pF1KB5 EAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREILSLMVKCPNE-
          :: ::::::..:.   . ... :: . .: ......: ::  :::::.:.. : :: 
NP_663 SPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNES
              70        80        90       100       110       120 

        140       150        160         170       180       190   
pF1KB5 -GCLHKMELRHLEDH-QAHCEFALMDC--PQCQRPFQKFHINIHILKDCPRRQVSCDNCA
        :: ... : ::  : .  :.:  . :  :.:..   .  .  :. : :  :...:..: 
NP_663 RGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCK
             130       140       150       160       170       180 

           200        210        220        230       240       250
pF1KB5 ASMAFEDKEIH-DQNCPLANVICEY-CNT-ILIREQMPNHYDLDCPTAPIPCTFSTFGCH
       ... .   . : : .:: . : : . :..  :.: ..  : . .: .::  :.:. .:: 
NP_663 SQVPMIALQKHEDTDCPCVVVSCPHKCSVQTLLRSELSAHLS-ECVNAPSTCSFKRYGCV
             190       200       210       220        230       240

              260       270       280           290         300    
pF1KB5 EKMQRNHLARHLQENTQSHMRMLAQAVHSL----SVIPDSGYISE--VRNFQETIHQLEG
        .   ...  :   .. .:. .: .  .::    :.. . .  ..  ...... : ..: 
NP_663 FQGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEI
              250       260       270       280       290       300

          310       320              330                        340
pF1KB5 RLVRQDHQIRELTAKM-------ETQSMYVSELKRTIR-----------------TLEDK
       .. :: ...:.  .:.       ..:.  ..:: . ::                 .:...
NP_663 EIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNR
              310       320       330       340       350       360

                                                           350     
pF1KB5 VAEIE-----AQQC----------------------------------------NGIYIW
       :.:.:     : :                                         ::. ::
NP_663 VTELESVDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIW
              370       380       390       400       410       420

         360       370       380       390       400       410     
pF1KB5 KIGNFGMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQ
       :: ..  . .     : . ..:  ::::  :::.: :..:.     . ....:::   :.
NP_663 KIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMR
              430       440       450       460        470         

         420       430       440       450       460       470     
pF1KB5 GEYDSHLPWPFQGTIRLTILDQSEAPVRQNHEEIMDAKPELLAFQRPTIPRNPKGFGYVT
       ::::. :::::.  . : ..::. .  :..  . .   :.  .:..::            
NP_663 GEYDALLPWPFKQKVTLMLMDQGSS--RRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVF
     480       490       500         510       520       530       

         480       490       500       510       520  
pF1KB5 FMHLEALRQRTFIKDDTLLVRCEVSTRFDMGSLRREGFQPRSTDAGV
                                                      
NP_663 VAQTVLENGTYIKDDTIFIKVIVDTSDLPDP                
       540       550       560                        

>>XP_016877107 (OMIM: 601896,614849) PREDICTED: TNF rece  (568 aa)
 initn: 506 init1: 242 opt: 504  Z-score: 371.9  bits: 78.6 E(85289): 5.6e-14
Smith-Waterman score: 638; 26.3% identity (54.2% similar) in 498 aa overlap (49-463:32-525)

       20        30        40        50        60        70        
pF1KB5 CCVAMASSCSAVTKDDSVGGTASTGNLSSSFMEEIQGYDVEFDPPLESKYECPICLMALR
                                     :. :  ::  .:   .:.::.:  : ..: 
XP_016 ESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLC
              10        20        30        40        50        60 

       80        90       100       110       120       130        
pF1KB5 EAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREILSLMVKCPNE-
          :: ::::::..:.   . ... :: . .: ......: ::  :::::.:.. : :: 
XP_016 SPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNES
              70        80        90       100       110       120 

        140       150        160         170       180       190   
pF1KB5 -GCLHKMELRHLEDH-QAHCEFALMDC--PQCQRPFQKFHINIHILKDCPRRQVSCDNCA
        :: ... : ::  : .  :.:  . :  :.:..   .  .  :. : :  :...:..: 
XP_016 RGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCK
             130       140       150       160       170       180 

           200        210        220        230       240       250
pF1KB5 ASMAFEDKEIH-DQNCPLANVICEY-CNT-ILIREQMPNHYDLDCPTAPIPCTFSTFGCH
       ... .   . : : .:: . : : . :..  :.: ..  : . .: .::  :.:. .:: 
XP_016 SQVPMIALQKHEDTDCPCVVVSCPHKCSVQTLLRSELSAHLS-ECVNAPSTCSFKRYGCV
             190       200       210       220        230       240

              260       270       280           290         300    
pF1KB5 EKMQRNHLARHLQENTQSHMRMLAQAVHSL----SVIPDSGYISE--VRNFQETIHQLEG
        .   ...  :   .. .:. .: .  .::    :.. . .  ..  ...... : ..: 
XP_016 FQGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEI
              250       260       270       280       290       300

          310       320              330                        340
pF1KB5 RLVRQDHQIRELTAKM-------ETQSMYVSELKRTIR-----------------TLEDK
       .. :: ...:.  .:.       ..:.  ..:: . ::                 .:...
XP_016 EIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNR
              310       320       330       340       350       360

                                                           350     
pF1KB5 VAEIE-----AQQC----------------------------------------NGIYIW
       :.:.:     : :                                         ::. ::
XP_016 VTELESVDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIW
              370       380       390       400       410       420

         360       370       380       390       400       410     
pF1KB5 KIGNFGMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQ
       :: ..  . .     : . ..:  ::::  :::.: :..:.     . ....:::   :.
XP_016 KIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMR
              430       440       450       460        470         

         420       430       440       450       460       470     
pF1KB5 GEYDSHLPWPFQGTIRLTILDQSEAPVRQNHEEIMDAKPELLAFQRPTIPRNPKGFGYVT
       ::::. :::::.  . : ..::. .  :..  . .   :.  .:..::            
XP_016 GEYDALLPWPFKQKVTLMLMDQGSS--RRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVF
     480       490       500         510       520       530       

         480       490       500       510       520  
pF1KB5 FMHLEALRQRTFIKDDTLLVRCEVSTRFDMGSLRREGFQPRSTDAGV
                                                      
XP_016 VAQTVLENGTYIKDDTIFIKVIVDTSDLPDP                
       540       550       560                        

>>XP_016877106 (OMIM: 601896,614849) PREDICTED: TNF rece  (568 aa)
 initn: 506 init1: 242 opt: 504  Z-score: 371.9  bits: 78.6 E(85289): 5.6e-14
Smith-Waterman score: 638; 26.3% identity (54.2% similar) in 498 aa overlap (49-463:32-525)

       20        30        40        50        60        70        
pF1KB5 CCVAMASSCSAVTKDDSVGGTASTGNLSSSFMEEIQGYDVEFDPPLESKYECPICLMALR
                                     :. :  ::  .:   .:.::.:  : ..: 
XP_016 ESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLC
              10        20        30        40        50        60 

       80        90       100       110       120       130        
pF1KB5 EAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREILSLMVKCPNE-
          :: ::::::..:.   . ... :: . .: ......: ::  :::::.:.. : :: 
XP_016 SPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNES
              70        80        90       100       110       120 

        140       150        160         170       180       190   
pF1KB5 -GCLHKMELRHLEDH-QAHCEFALMDC--PQCQRPFQKFHINIHILKDCPRRQVSCDNCA
        :: ... : ::  : .  :.:  . :  :.:..   .  .  :. : :  :...:..: 
XP_016 RGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCK
             130       140       150       160       170       180 

           200        210        220        230       240       250
pF1KB5 ASMAFEDKEIH-DQNCPLANVICEY-CNT-ILIREQMPNHYDLDCPTAPIPCTFSTFGCH
       ... .   . : : .:: . : : . :..  :.: ..  : . .: .::  :.:. .:: 
XP_016 SQVPMIALQKHEDTDCPCVVVSCPHKCSVQTLLRSELSAHLS-ECVNAPSTCSFKRYGCV
             190       200       210       220        230       240

              260       270       280           290         300    
pF1KB5 EKMQRNHLARHLQENTQSHMRMLAQAVHSL----SVIPDSGYISE--VRNFQETIHQLEG
        .   ...  :   .. .:. .: .  .::    :.. . .  ..  ...... : ..: 
XP_016 FQGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEI
              250       260       270       280       290       300

          310       320              330                        340
pF1KB5 RLVRQDHQIRELTAKM-------ETQSMYVSELKRTIR-----------------TLEDK
       .. :: ...:.  .:.       ..:.  ..:: . ::                 .:...
XP_016 EIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNR
              310       320       330       340       350       360

                                                           350     
pF1KB5 VAEIE-----AQQC----------------------------------------NGIYIW
       :.:.:     : :                                         ::. ::
XP_016 VTELESVDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIW
              370       380       390       400       410       420

         360       370       380       390       400       410     
pF1KB5 KIGNFGMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQ
       :: ..  . .     : . ..:  ::::  :::.: :..:.     . ....:::   :.
XP_016 KIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMR
              430       440       450       460        470         

         420       430       440       450       460       470     
pF1KB5 GEYDSHLPWPFQGTIRLTILDQSEAPVRQNHEEIMDAKPELLAFQRPTIPRNPKGFGYVT
       ::::. :::::.  . : ..::. .  :..  . .   :.  .:..::            
XP_016 GEYDALLPWPFKQKVTLMLMDQGSS--RRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVF
     480       490       500         510       520       530       

         480       490       500       510       520  
pF1KB5 FMHLEALRQRTFIKDDTLLVRCEVSTRFDMGSLRREGFQPRSTDAGV
                                                      
XP_016 VAQTVLENGTYIKDDTIFIKVIVDTSDLPDP                
       540       550       560                        

>>NP_003291 (OMIM: 601896,614849) TNF receptor-associate  (568 aa)
 initn: 506 init1: 242 opt: 504  Z-score: 371.9  bits: 78.6 E(85289): 5.6e-14
Smith-Waterman score: 638; 26.3% identity (54.2% similar) in 498 aa overlap (49-463:32-525)

       20        30        40        50        60        70        
pF1KB5 CCVAMASSCSAVTKDDSVGGTASTGNLSSSFMEEIQGYDVEFDPPLESKYECPICLMALR
                                     :. :  ::  .:   .:.::.:  : ..: 
NP_003 ESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLC
              10        20        30        40        50        60 

       80        90       100       110       120       130        
pF1KB5 EAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREILSLMVKCPNE-
          :: ::::::..:.   . ... :: . .: ......: ::  :::::.:.. : :: 
NP_003 SPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNES
              70        80        90       100       110       120 

        140       150        160         170       180       190   
pF1KB5 -GCLHKMELRHLEDH-QAHCEFALMDC--PQCQRPFQKFHINIHILKDCPRRQVSCDNCA
        :: ... : ::  : .  :.:  . :  :.:..   .  .  :. : :  :...:..: 
NP_003 RGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCK
             130       140       150       160       170       180 

           200        210        220        230       240       250
pF1KB5 ASMAFEDKEIH-DQNCPLANVICEY-CNT-ILIREQMPNHYDLDCPTAPIPCTFSTFGCH
       ... .   . : : .:: . : : . :..  :.: ..  : . .: .::  :.:. .:: 
NP_003 SQVPMIALQKHEDTDCPCVVVSCPHKCSVQTLLRSELSAHLS-ECVNAPSTCSFKRYGCV
             190       200       210       220        230       240

              260       270       280           290         300    
pF1KB5 EKMQRNHLARHLQENTQSHMRMLAQAVHSL----SVIPDSGYISE--VRNFQETIHQLEG
        .   ...  :   .. .:. .: .  .::    :.. . .  ..  ...... : ..: 
NP_003 FQGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEI
              250       260       270       280       290       300

          310       320              330                        340
pF1KB5 RLVRQDHQIRELTAKM-------ETQSMYVSELKRTIR-----------------TLEDK
       .. :: ...:.  .:.       ..:.  ..:: . ::                 .:...
NP_003 EIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNR
              310       320       330       340       350       360

                                                           350     
pF1KB5 VAEIE-----AQQC----------------------------------------NGIYIW
       :.:.:     : :                                         ::. ::
NP_003 VTELESVDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIW
              370       380       390       400       410       420

         360       370       380       390       400       410     
pF1KB5 KIGNFGMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQ
       :: ..  . .     : . ..:  ::::  :::.: :..:.     . ....:::   :.
NP_003 KIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMR
              430       440       450       460        470         

         420       430       440       450       460       470     
pF1KB5 GEYDSHLPWPFQGTIRLTILDQSEAPVRQNHEEIMDAKPELLAFQRPTIPRNPKGFGYVT
       ::::. :::::.  . : ..::. .  :..  . .   :.  .:..::            
NP_003 GEYDALLPWPFKQKVTLMLMDQGSS--RRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVF
     480       490       500         510       520       530       

         480       490       500       510       520  
pF1KB5 FMHLEALRQRTFIKDDTLLVRCEVSTRFDMGSLRREGFQPRSTDAGV
                                                      
NP_003 VAQTVLENGTYIKDDTIFIKVIVDTSDLPDP                
       540       550       560                        




522 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 17:46:51 2016 done: Thu Nov  3 17:46:52 2016
 Total Scan time:  9.320 Total Display time:  0.080

Function used was FASTA [36.3.4 Apr, 2011]
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