Result of FASTA (omim) for pF1KB4523
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB4523, 505 aa
  1>>>pF1KB4523 505 - 505 aa - 505 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 10.8983+/-0.000634; mu= -8.2860+/- 0.037
 mean_var=843.1555+/-196.819, 0's: 0 Z-trim(114.0): 149  B-trim: 0 in 0/56
 Lambda= 0.044169
 statistics sampled from 23490 (23613) to 23490 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.621), E-opt: 0.2 (0.277), width:  16
 Scan time:  9.460

The best scores are:                                      opt bits E(85289)
NP_004293 (OMIM: 601300) activin receptor type-1B  ( 505) 3453 236.9 1.1e-61
NP_064732 (OMIM: 601300) activin receptor type-1B  ( 453) 3098 214.2 6.5e-55
XP_016875690 (OMIM: 601300) PREDICTED: activin rec ( 381) 2579 181.0 5.4e-45
NP_001293139 (OMIM: 132800,190181) TGF-beta recept ( 507) 2327 165.1 4.2e-40
NP_004603 (OMIM: 132800,190181) TGF-beta receptor  ( 503) 2314 164.3 7.5e-40
XP_011517250 (OMIM: 132800,190181) PREDICTED: TGF- ( 438) 2210 157.6 6.9e-38
XP_016870552 (OMIM: 132800,190181) PREDICTED: TGF- ( 438) 2210 157.6 6.9e-38
XP_011517251 (OMIM: 132800,190181) PREDICTED: TGF- ( 434) 2197 156.7 1.2e-37
NP_660302 (OMIM: 608981) activin receptor type-1C  ( 493) 2157 154.3 7.6e-37
NP_001104501 (OMIM: 608981) activin receptor type- ( 443) 2056 147.8 6.3e-35
XP_011517252 (OMIM: 132800,190181) PREDICTED: TGF- ( 357) 1907 138.1 4.1e-32
NP_001124388 (OMIM: 132800,190181) TGF-beta recept ( 426) 1907 138.2 4.4e-32
XP_011537269 (OMIM: 601300) PREDICTED: activin rec ( 312) 1866 135.4 2.3e-31
XP_011537268 (OMIM: 601300) PREDICTED: activin rec ( 422) 1866 135.6 2.7e-31
NP_064733 (OMIM: 601300) activin receptor type-1B  ( 546) 1866 135.8 3.1e-31
NP_001104502 (OMIM: 608981) activin receptor type- ( 413) 1764 129.1 2.4e-29
XP_016864050 (OMIM: 112600,603248,609441,616849) P ( 502) 1616 119.8 1.8e-26
NP_001243723 (OMIM: 112600,603248,609441,616849) b ( 502) 1616 119.8 1.8e-26
NP_001243721 (OMIM: 112600,603248,609441,616849) b ( 502) 1616 119.8 1.8e-26
NP_001194 (OMIM: 112600,603248,609441,616849) bone ( 502) 1616 119.8 1.8e-26
XP_016864048 (OMIM: 112600,603248,609441,616849) P ( 502) 1616 119.8 1.8e-26
XP_016864049 (OMIM: 112600,603248,609441,616849) P ( 502) 1616 119.8 1.8e-26
XP_016864047 (OMIM: 112600,603248,609441,616849) P ( 502) 1616 119.8 1.8e-26
XP_011530503 (OMIM: 112600,603248,609441,616849) P ( 502) 1616 119.8 1.8e-26
NP_001243722 (OMIM: 112600,603248,609441,616849) b ( 532) 1616 119.9 1.9e-26
XP_016875689 (OMIM: 601300) PREDICTED: activin rec ( 494) 1589 118.1   6e-26
XP_016875688 (OMIM: 601300) PREDICTED: activin rec ( 494) 1589 118.1   6e-26
XP_011538405 (OMIM: 174900,601299,610069) PREDICTE ( 532) 1564 116.6 1.9e-25
XP_011538406 (OMIM: 174900,601299,610069) PREDICTE ( 532) 1564 116.6 1.9e-25
NP_004320 (OMIM: 174900,601299,610069) bone morpho ( 532) 1564 116.6 1.9e-25
XP_005246997 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1519 113.7 1.3e-24
NP_001104537 (OMIM: 102576,135100) activin recepto ( 509) 1519 113.7 1.3e-24
XP_011510409 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1519 113.7 1.3e-24
NP_001096 (OMIM: 102576,135100) activin receptor t ( 509) 1519 113.7 1.3e-24
XP_005246996 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1519 113.7 1.3e-24
XP_006712888 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1519 113.7 1.3e-24
XP_011510408 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1519 113.7 1.3e-24
XP_011510410 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1519 113.7 1.3e-24
NP_001070869 (OMIM: 600376,601284) serine/threonin ( 503) 1437 108.4   5e-23
XP_005269292 (OMIM: 600376,601284) PREDICTED: seri ( 503) 1437 108.4   5e-23
NP_000011 (OMIM: 600376,601284) serine/threonine-p ( 503) 1437 108.4   5e-23
NP_001104503 (OMIM: 608981) activin receptor type- ( 336) 1289 98.7 2.8e-20
XP_011537310 (OMIM: 600376,601284) PREDICTED: seri ( 413) 1213 94.0   9e-19
XP_016862595 (OMIM: 133239,190182,610168,614331) P ( 532)  789 67.2 1.4e-10
XP_011532347 (OMIM: 133239,190182,610168,614331) P ( 532)  789 67.2 1.4e-10
NP_003233 (OMIM: 133239,190182,610168,614331) TGF- ( 567)  789 67.2 1.4e-10
XP_011532345 (OMIM: 133239,190182,610168,614331) P ( 576)  789 67.2 1.4e-10
NP_001020018 (OMIM: 133239,190182,610168,614331) T ( 592)  789 67.2 1.5e-10
NP_001265509 (OMIM: 102581) activin receptor type- ( 405)  763 65.3 3.8e-10
NP_001607 (OMIM: 102581) activin receptor type-2A  ( 513)  763 65.5 4.3e-10


>>NP_004293 (OMIM: 601300) activin receptor type-1B isof  (505 aa)
 initn: 3453 init1: 3453 opt: 3453  Z-score: 1228.7  bits: 236.9 E(85289): 1.1e-61
Smith-Waterman score: 3453; 100.0% identity (100.0% similar) in 505 aa overlap (1-505:1-505)

               10        20        30        40        50        60
pF1KB4 MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLD
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 GMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 MWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQ
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 DLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 DLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSRE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB4 ERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 ERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVT
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB4 IEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 IEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRH
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB4 DAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 DAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSG
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB4 GVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYAN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYAN
              430       440       450       460       470       480

              490       500     
pF1KB4 GAARLTALRIKKTLSQLSVQEDVKI
       :::::::::::::::::::::::::
NP_004 GAARLTALRIKKTLSQLSVQEDVKI
              490       500     

>>NP_064732 (OMIM: 601300) activin receptor type-1B isof  (453 aa)
 initn: 3098 init1: 3098 opt: 3098  Z-score: 1106.8  bits: 214.2 E(85289): 6.5e-55
Smith-Waterman score: 3098; 100.0% identity (100.0% similar) in 453 aa overlap (53-505:1-453)

             30        40        50        60        70        80  
pF1KB4 GSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLDGMEHHVRTCIPKVELVPAGKPF
                                     ::::::::::::::::::::::::::::::
NP_064                               MVSIFNLDGMEHHVRTCIPKVELVPAGKPF
                                             10        20        30

             90       100       110       120       130       140  
pF1KB4 YCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPVELVGIIAGPVFLLFLII
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 YCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPVELVGIIAGPVFLLFLII
               40        50        60        70        80        90

            150       160       170       180       190       200  
pF1KB4 IIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQDLVYDLSTSGSGSGLPLFVQRT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 IIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQDLVYDLSTSGSGSGLPLFVQRT
              100       110       120       130       140       150

            210       220       230       240       250       260  
pF1KB4 VARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 VARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENIL
              160       170       180       190       200       210

            270       280       290       300       310       320  
pF1KB4 GFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 GFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEI
              220       230       240       250       260       270

            330       340       350       360       370       380  
pF1KB4 VGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 VGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMA
              280       290       300       310       320       330

            390       400       410       420       430       440  
pF1KB4 PEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 PEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEE
              340       350       360       370       380       390

            450       460       470       480       490       500  
pF1KB4 MRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 MRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQED
              400       410       420       430       440       450

          
pF1KB4 VKI
       :::
NP_064 VKI
          

>>XP_016875690 (OMIM: 601300) PREDICTED: activin recepto  (381 aa)
 initn: 2579 init1: 2579 opt: 2579  Z-score: 928.7  bits: 181.0 E(85289): 5.4e-45
Smith-Waterman score: 2579; 100.0% identity (100.0% similar) in 379 aa overlap (1-379:1-379)

               10        20        30        40        50        60
pF1KB4 MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLD
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 GMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 MWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQ
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 DLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSRE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB4 ERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVT
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB4 IEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRH
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB4 DAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSG
       :::::::::::::::::::                                         
XP_016 DAVTDTIDIAPNQRVGTKRSP                                       
              370       380                                        

>>NP_001293139 (OMIM: 132800,190181) TGF-beta receptor t  (507 aa)
 initn: 2247 init1: 2130 opt: 2327  Z-score: 840.9  bits: 165.1 E(85289): 4.2e-40
Smith-Waterman score: 2327; 69.3% identity (84.3% similar) in 511 aa overlap (3-505:2-507)

               10        20           30        40        50       
pF1KB4 MAESAGASSFFPLVVLLLAGSGGSGPR---GVQALLCACTSCLQANYTCETDGACMVSIF
         :.: :.    :..:.::......     :. :: : :  : . :.:: ::: :.::. 
NP_001  MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVT
                10        20        30        40        50         

        60        70        80           90       100       110    
pF1KB4 NLDGMEHHVRTCIPKVELVPAGKPFYCLSSE---DLRNTHCCYTDYCNRIDLRVPSGHLK
       .      :   :: ...:.:  .:: :  :    .. .:.::  :.::.:.: . .: ..
NP_001 ETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPT-TGPFS
      60        70        80        90       100       110         

          120       130       140       150        160       170   
pF1KB4 EPEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQR-VYHNRQRLDMEDPSCEM-C
           :.. :::::...:::::   :. : ....:   :.: : :.:   . :::: .   
NP_001 VKSSPGL-GPVELAAVIAGPVC--FVCISLMLMVYICHNRTVIHHRVP-NEEDPSLDRPF
      120        130         140       150       160        170    

            180       190       200       210       220       230  
pF1KB4 LSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVA
       .:.  ::.::.::..::::::::::.::::.:::::::: ::::::::::::.::: .::
NP_001 ISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVA
          180       190       200       210       220       230    

            240       250       260       270       280       290  
pF1KB4 VKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFD
          240       250       260       270       280       290    

            300       310       320       330       340       350  
pF1KB4 YLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIA
       ::::::::.:::::::::.::::::::::::::::::.::::::::::::::::: : ::
NP_001 YLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIA
          300       310       320       330       340       350    

            360       370       380       390       400       410  
pF1KB4 DLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWE
       :::::::::..:::::::::.::::::::::::::..::::::.::: :::::.:::.::
NP_001 DLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWE
          360       370       380       390       400       410    

            420       430       440       450       460       470  
pF1KB4 IARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKM
       :::::. ::.::.::::::::::::::.::::::::.::::::::: ::: ::::::.:.
NP_001 IARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKI
          420       430       440       450       460       470    

            480       490       500     
pF1KB4 MRECWYANGAARLTALRIKKTLSQLSVQEDVKI
       :::::::::::::::::::::::::: :: .:.
NP_001 MRECWYANGAARLTALRIKKTLSQLSQQEGIKM
          480       490       500       

>>NP_004603 (OMIM: 132800,190181) TGF-beta receptor type  (503 aa)
 initn: 2285 init1: 1991 opt: 2314  Z-score: 836.4  bits: 164.3 E(85289): 7.5e-40
Smith-Waterman score: 2314; 69.5% identity (84.1% similar) in 511 aa overlap (3-505:2-503)

               10        20           30        40        50       
pF1KB4 MAESAGASSFFPLVVLLLAGSGGSGPR---GVQALLCACTSCLQANYTCETDGACMVSIF
         :.: :.    :..:.::......     :. :: : :  : . :.:: ::: :.::. 
NP_004  MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVT
                10        20        30        40        50         

        60        70        80           90       100       110    
pF1KB4 NLDGMEHHVRTCIPKVELVPAGKPFYCLSSE---DLRNTHCCYTDYCNRIDLRVPSGHLK
       .      :   :: ...:.:  .:: :  :    .. .:.::  :.::.:.:  :.  .:
NP_004 ETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIEL--PTT-VK
      60        70        80        90       100       110         

          120       130       140       150        160       170   
pF1KB4 EPEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQR-VYHNRQRLDMEDPSCEM-C
           :.. :::::...:::::   :. : ....:   :.: : :.:   . :::: .   
NP_004 S--SPGL-GPVELAAVIAGPVC--FVCISLMLMVYICHNRTVIHHRVP-NEEDPSLDRPF
          120        130         140       150        160       170

            180       190       200       210       220       230  
pF1KB4 LSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVA
       .:.  ::.::.::..::::::::::.::::.:::::::: ::::::::::::.::: .::
NP_004 ISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVA
              180       190       200       210       220       230

            240       250       260       270       280       290  
pF1KB4 VKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFD
              240       250       260       270       280       290

            300       310       320       330       340       350  
pF1KB4 YLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIA
       ::::::::.:::::::::.::::::::::::::::::.::::::::::::::::: : ::
NP_004 YLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIA
              300       310       320       330       340       350

            360       370       380       390       400       410  
pF1KB4 DLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWE
       :::::::::..:::::::::.::::::::::::::..::::::.::: :::::.:::.::
NP_004 DLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWE
              360       370       380       390       400       410

            420       430       440       450       460       470  
pF1KB4 IARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKM
       :::::. ::.::.::::::::::::::.::::::::.::::::::: ::: ::::::.:.
NP_004 IARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKI
              420       430       440       450       460       470

            480       490       500     
pF1KB4 MRECWYANGAARLTALRIKKTLSQLSVQEDVKI
       :::::::::::::::::::::::::: :: .:.
NP_004 MRECWYANGAARLTALRIKKTLSQLSQQEGIKM
              480       490       500   

>>XP_011517250 (OMIM: 132800,190181) PREDICTED: TGF-beta  (438 aa)
 initn: 2169 init1: 1991 opt: 2210  Z-score: 801.1  bits: 157.6 E(85289): 6.9e-38
Smith-Waterman score: 2210; 74.9% identity (88.5% similar) in 442 aa overlap (69-505:2-438)

       40        50        60        70        80           90     
pF1KB4 CLQANYTCETDGACMVSIFNLDGMEHHVRTCIPKVELVPAGKPFYCLSSE---DLRNTHC
                                     :: ...:.:  .:: :  :    .. .:.:
XP_011                              MCIAEIDLIPRDRPFVCAPSSKTGSVTTTYC
                                            10        20        30 

         100       110       120       130       140       150     
pF1KB4 CYTDYCNRIDLRVPSGHLKEPEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQR-
       :  :.::.:.: . .: ..    :.. :::::...:::::   :. : ....:   :.: 
XP_011 CNQDHCNKIELPT-TGPFSVKSSPGL-GPVELAAVIAGPVC--FVCISLMLMVYICHNRT
              40         50         60        70          80       

          160       170        180       190       200       210   
pF1KB4 VYHNRQRLDMEDPSCEM-CLSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEII
       : :.:   . :::: .   .:.  ::.::.::..::::::::::.::::.:::::::: :
XP_011 VIHHRVP-NEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESI
        90        100       110       120       130       140      

           220       230       240       250       260       270   
pF1KB4 GKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNG
       :::::::::::.::: .:::::::::::::::::::::::::::::::::::::::::::
XP_011 GKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNG
        150       160       170       180       190       200      

           280       290       300       310       320       330   
pF1KB4 TWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAH
       :::::::::::::::::::::::::::.:::::::::.::::::::::::::::::.:::
XP_011 TWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAH
        210       220       230       240       250       260      

           340       350       360       370       380       390   
pF1KB4 RDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMK
       :::::::::::::: : :::::::::::..:::::::::.::::::::::::::..::::
XP_011 RDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMK
        270       280       290       300       310       320      

           400       410       420       430       440       450   
pF1KB4 HFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLR
       ::.::: :::::.:::.:::::::. ::.::.::::::::::::::.::::::::.::::
XP_011 HFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLR
        330       340       350       360       370       380      

           460       470       480       490       500     
pF1KB4 PNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQEDVKI
       ::::: ::: ::::::.:.:::::::::::::::::::::::::: :: .:.
XP_011 PNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
        390       400       410       420       430        

>>XP_016870552 (OMIM: 132800,190181) PREDICTED: TGF-beta  (438 aa)
 initn: 2169 init1: 1991 opt: 2210  Z-score: 801.1  bits: 157.6 E(85289): 6.9e-38
Smith-Waterman score: 2210; 74.9% identity (88.5% similar) in 442 aa overlap (69-505:2-438)

       40        50        60        70        80           90     
pF1KB4 CLQANYTCETDGACMVSIFNLDGMEHHVRTCIPKVELVPAGKPFYCLSSE---DLRNTHC
                                     :: ...:.:  .:: :  :    .. .:.:
XP_016                              MCIAEIDLIPRDRPFVCAPSSKTGSVTTTYC
                                            10        20        30 

         100       110       120       130       140       150     
pF1KB4 CYTDYCNRIDLRVPSGHLKEPEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQR-
       :  :.::.:.: . .: ..    :.. :::::...:::::   :. : ....:   :.: 
XP_016 CNQDHCNKIELPT-TGPFSVKSSPGL-GPVELAAVIAGPVC--FVCISLMLMVYICHNRT
              40         50         60        70          80       

          160       170        180       190       200       210   
pF1KB4 VYHNRQRLDMEDPSCEM-CLSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEII
       : :.:   . :::: .   .:.  ::.::.::..::::::::::.::::.:::::::: :
XP_016 VIHHRVP-NEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESI
        90        100       110       120       130       140      

           220       230       240       250       260       270   
pF1KB4 GKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNG
       :::::::::::.::: .:::::::::::::::::::::::::::::::::::::::::::
XP_016 GKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNG
        150       160       170       180       190       200      

           280       290       300       310       320       330   
pF1KB4 TWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAH
       :::::::::::::::::::::::::::.:::::::::.::::::::::::::::::.:::
XP_016 TWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAH
        210       220       230       240       250       260      

           340       350       360       370       380       390   
pF1KB4 RDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMK
       :::::::::::::: : :::::::::::..:::::::::.::::::::::::::..::::
XP_016 RDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMK
        270       280       290       300       310       320      

           400       410       420       430       440       450   
pF1KB4 HFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLR
       ::.::: :::::.:::.:::::::. ::.::.::::::::::::::.::::::::.::::
XP_016 HFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLR
        330       340       350       360       370       380      

           460       470       480       490       500     
pF1KB4 PNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQEDVKI
       ::::: ::: ::::::.:.:::::::::::::::::::::::::: :: .:.
XP_016 PNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
        390       400       410       420       430        

>>XP_011517251 (OMIM: 132800,190181) PREDICTED: TGF-beta  (434 aa)
 initn: 2176 init1: 1991 opt: 2197  Z-score: 796.7  bits: 156.7 E(85289): 1.2e-37
Smith-Waterman score: 2197; 75.1% identity (88.2% similar) in 442 aa overlap (69-505:2-434)

       40        50        60        70        80           90     
pF1KB4 CLQANYTCETDGACMVSIFNLDGMEHHVRTCIPKVELVPAGKPFYCLSSE---DLRNTHC
                                     :: ...:.:  .:: :  :    .. .:.:
XP_011                              MCIAEIDLIPRDRPFVCAPSSKTGSVTTTYC
                                            10        20        30 

         100       110       120       130       140       150     
pF1KB4 CYTDYCNRIDLRVPSGHLKEPEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQR-
       :  :.::.:.:  :.  .:    :.. :::::...:::::   :. : ....:   :.: 
XP_011 CNQDHCNKIEL--PTT-VKSS--PGL-GPVELAAVIAGPVC--FVCISLMLMVYICHNRT
              40             50         60          70        80   

          160       170        180       190       200       210   
pF1KB4 VYHNRQRLDMEDPSCEM-CLSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEII
       : :.:   . :::: .   .:.  ::.::.::..::::::::::.::::.:::::::: :
XP_011 VIHHRVP-NEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESI
            90        100       110       120       130       140  

           220       230       240       250       260       270   
pF1KB4 GKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNG
       :::::::::::.::: .:::::::::::::::::::::::::::::::::::::::::::
XP_011 GKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNG
            150       160       170       180       190       200  

           280       290       300       310       320       330   
pF1KB4 TWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAH
       :::::::::::::::::::::::::::.:::::::::.::::::::::::::::::.:::
XP_011 TWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAH
            210       220       230       240       250       260  

           340       350       360       370       380       390   
pF1KB4 RDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMK
       :::::::::::::: : :::::::::::..:::::::::.::::::::::::::..::::
XP_011 RDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMK
            270       280       290       300       310       320  

           400       410       420       430       440       450   
pF1KB4 HFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLR
       ::.::: :::::.:::.:::::::. ::.::.::::::::::::::.::::::::.::::
XP_011 HFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLR
            330       340       350       360       370       380  

           460       470       480       490       500     
pF1KB4 PNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQEDVKI
       ::::: ::: ::::::.:.:::::::::::::::::::::::::: :: .:.
XP_011 PNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
            390       400       410       420       430    

>>NP_660302 (OMIM: 608981) activin receptor type-1C isof  (493 aa)
 initn: 2108 init1: 1847 opt: 2157  Z-score: 782.4  bits: 154.3 E(85289): 7.6e-37
Smith-Waterman score: 2165; 65.8% identity (84.7% similar) in 491 aa overlap (15-504:13-492)

               10        20        30        40        50        60
pF1KB4 MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLD
                     .::::...  .:    .: :.:  : ..:.::.:.::: .:..  .
NP_660   MTRALCSALRQALLLLAAAAELSP----GLKCVCLLCDSSNFTCQTEGACWASVMLTN
                 10        20            30        40        50    

               70        80        90       100       110       120
pF1KB4 GMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPS
       : :. ...:.   ::   .   .: ::... .:.::.::.:: : :..:..    :. :.
NP_660 GKEQVIKSCVSLPEL---NAQVFCHSSNNVTKTECCFTDFCNNITLHLPTAS---PNAPK
           60           70        80        90       100           

              130       140       150       160       170          
pF1KB4 MWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCL-SKDKTL
       . ::.::. ::. :: :: .  ...  . . .:  :....: ..:.:  :  : .  :::
NP_660 L-GPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTL
       110       120       130       140       150       160       

     180       190       200       210       220       230         
pF1KB4 QDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSR
       .::.::...:::::::::.::::.:::::::::.:::::::::.::: : ::::::::::
NP_660 KDLIYDVTASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSR
       170       180       190       200       210       220       

     240       250       260       270       280       290         
pF1KB4 EERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTV
       .::::::::::::::::::::::::::::::::::::::::::.:::.:::.:::::  :
NP_660 DERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIV
       230       240       250       260       270       280       

     300       310       320       330       340       350         
pF1KB4 TIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVR
       :. :::::::: ::::::::::::::::::.:::::.:::::::::   ::::::::::.
NP_660 TVAGMIKLALSIASGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVK
       290       300       310       320       330       340       

     360       370       380       390       400       410         
pF1KB4 HDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNS
       ::.. .::::  : .::::::::::.::.:.:.. :.::: ::::..:::::::::::. 
NP_660 HDSILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSV
       350       360       370       380       390       400       

     420       430       440       450       460       470         
pF1KB4 GGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYA
       ::. :::::::::.::::::::::::::::::.::.::: ::: :::::::..:::::::
NP_660 GGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYA
       410       420       430       440       450       460       

     480       490       500     
pF1KB4 NGAARLTALRIKKTLSQLSVQEDVKI
       ::::::::::::::.::: :.:: : 
NP_660 NGAARLTALRIKKTISQLCVKEDCKA
       470       480       490   

>>NP_001104501 (OMIM: 608981) activin receptor type-1C i  (443 aa)
 initn: 1980 init1: 1847 opt: 2056  Z-score: 748.1  bits: 147.8 E(85289): 6.3e-35
Smith-Waterman score: 2056; 68.6% identity (86.1% similar) in 446 aa overlap (60-504:4-442)

      30        40        50        60        70        80         
pF1KB4 QALLCACTSCLQANYTCETDGACMVSIFNLDGMEHHVRTCIPKVELVPAGKPFYCLSSED
                                     .: :. ...:.   ::   .   .: ::..
NP_001                            MLTNGKEQVIKSCVSLPEL---NAQVFCHSSNN
                                          10           20        30

      90       100       110       120       130       140         
pF1KB4 LRNTHCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVI
       . .:.::.::.:: : :..:..    :. :.. ::.::. ::. :: :: .  ...  . 
NP_001 VTKTECCFTDFCNNITLHLPTA---SPNAPKL-GPMELAIIITVPVCLLSIAAMLTVWAC
               40        50            60        70        80      

     150       160       170        180       190       200        
pF1KB4 NYHQRVYHNRQRLDMEDPSCEMCL-SKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIV
       . .:  :....: ..:.:  :  : .  :::.::.::...:::::::::.::::.:::::
NP_001 QGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSGSGLPLLVQRTIARTIV
         90       100       110       120       130       140      

      210       220       230       240       250       260        
pF1KB4 LQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAAD
       ::::.:::::::::.::: : ::::::::::.::::::::::::::::::::::::::::
NP_001 LQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAAD
        150       160       170       180       190       200      

      270       280       290       300       310       320        
pF1KB4 NKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGK
       ::::::::::::::.:::.:::.:::::  ::. :::::::: :::::::::::::::::
NP_001 NKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGK
        210       220       230       240       250       260      

      330       340       350       360       370       380        
pF1KB4 PGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDE
       :.:::::.:::::::::   ::::::::::.::.. .::::  : .::::::::::.::.
NP_001 PAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDD
        270       280       290       300       310       320      

      390       400       410       420       430       440        
pF1KB4 TINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVC
       :.:.. :.::: ::::..:::::::::::. ::. :::::::::.:::::::::::::::
NP_001 TMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVC
        330       340       350       360       370       380      

      450       460       470       480       490       500     
pF1KB4 DQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQEDVKI
       :::.::.::: ::: :::::::..:::::::::::::::::::::.::: :.:: : 
NP_001 DQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVKEDCKA
        390       400       410       420       430       440   




505 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 15:06:41 2016 done: Thu Nov  3 15:06:43 2016
 Total Scan time:  9.460 Total Display time:  0.090

Function used was FASTA [36.3.4 Apr, 2011]
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