Result of FASTA (omim) for pF1KB3725
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB3725, 1375 aa
  1>>>pF1KB3725 1375 - 1375 aa - 1375 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 9.5076+/-0.000656; mu= 4.6929+/- 0.040
 mean_var=580.4221+/-124.528, 0's: 0 Z-trim(116.1): 1865  B-trim: 33 in 1/52
 Lambda= 0.053236
 statistics sampled from 24510 (27062) to 24510 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.632), E-opt: 0.2 (0.317), width:  16
 Scan time: 15.160

The best scores are:                                      opt bits E(85289)
NP_005914 (OMIM: 602448) mitogen-activated protein (1374) 9002 709.1 5.7e-203
XP_016866362 (OMIM: 602448) PREDICTED: mitogen-act (1483) 9002 709.1 5.9e-203
XP_016866361 (OMIM: 602448) PREDICTED: mitogen-act (1484) 8990 708.2 1.1e-202
XP_016866360 (OMIM: 602448) PREDICTED: mitogen-act (1493) 8867 698.8 7.8e-200
XP_016866359 (OMIM: 602448) PREDICTED: mitogen-act (1494) 8855 697.8 1.5e-199
XP_016866366 (OMIM: 602448) PREDICTED: mitogen-act (1181) 7696 608.7 8.2e-173
XP_011534141 (OMIM: 602448) PREDICTED: mitogen-act (1286) 7691 608.3 1.1e-172
XP_016866365 (OMIM: 602448) PREDICTED: mitogen-act (1191) 7561 598.3 1.1e-169
XP_016866363 (OMIM: 602448) PREDICTED: mitogen-act (1458) 4940 397.1 4.8e-109
NP_001001671 (OMIM: 300820) mitogen-activated prot (1313) 4082 331.2 3.1e-89
XP_016866364 (OMIM: 602448) PREDICTED: mitogen-act (1447) 3681 300.4 6.1e-80
XP_011543809 (OMIM: 300820) PREDICTED: mitogen-act (1324) 3569 291.8 2.3e-77
XP_011543810 (OMIM: 300820) PREDICTED: mitogen-act (1295) 3504 286.8 7.1e-76
NP_001284538 (OMIM: 604468) mitogen-activated prot (1280) 3185 262.3 1.7e-68
NP_004663 (OMIM: 604468) mitogen-activated protein (1288) 3181 262.0 2.1e-68
XP_016885000 (OMIM: 300820) PREDICTED: mitogen-act ( 825) 2930 242.4 1.1e-62
XP_016858261 (OMIM: 604468) PREDICTED: mitogen-act ( 801) 2458 206.1 8.5e-52
XP_011543812 (OMIM: 300820) PREDICTED: mitogen-act ( 871) 2425 203.6 5.2e-51
XP_016858260 (OMIM: 604468) PREDICTED: mitogen-act ( 869) 1978 169.3 1.1e-40
XP_011543813 (OMIM: 300820) PREDICTED: mitogen-act ( 748) 1968 168.4 1.8e-40
NP_001317360 (OMIM: 602539) mitogen-activated prot ( 622)  583 61.9 1.7e-08
NP_002392 (OMIM: 602539) mitogen-activated protein ( 626)  583 61.9 1.7e-08
XP_005257433 (OMIM: 602539) PREDICTED: mitogen-act ( 653)  583 61.9 1.7e-08
NP_976226 (OMIM: 602539) mitogen-activated protein ( 657)  583 62.0 1.7e-08
NP_006600 (OMIM: 609487) mitogen-activated protein ( 619)  567 60.7 3.9e-08
NP_001278887 (OMIM: 602425) mitogen-activated prot (1061)  568 61.1 4.9e-08
XP_016866358 (OMIM: 602425) PREDICTED: mitogen-act (1517)  568 61.4 5.9e-08
XP_005267046 (OMIM: 602425) PREDICTED: mitogen-act (1554)  568 61.4 5.9e-08
NP_006715 (OMIM: 602425) mitogen-activated protein (1558)  568 61.4 5.9e-08
NP_001288001 (OMIM: 602425) mitogen-activated prot (1604)  568 61.4   6e-08
NP_005913 (OMIM: 602425) mitogen-activated protein (1608)  568 61.4   6e-08
XP_016864974 (OMIM: 600982,613762) PREDICTED: mito (1349)  564 61.0 6.8e-08
XP_016864973 (OMIM: 600982,613762) PREDICTED: mito (1375)  564 61.0 6.9e-08
NP_005912 (OMIM: 600982,613762) mitogen-activated  (1512)  564 61.1 7.2e-08
XP_016873337 (OMIM: 602590) PREDICTED: serine/thre ( 545)  500 55.4 1.3e-06
XP_016873336 (OMIM: 602590) PREDICTED: serine/thre ( 545)  500 55.4 1.3e-06
NP_002567 (OMIM: 602590) serine/threonine-protein  ( 545)  500 55.4 1.3e-06
XP_016873338 (OMIM: 602590) PREDICTED: serine/thre ( 545)  500 55.4 1.3e-06
XP_016873339 (OMIM: 602590) PREDICTED: serine/thre ( 545)  500 55.4 1.3e-06
XP_016873335 (OMIM: 602590) PREDICTED: serine/thre ( 545)  500 55.4 1.3e-06
XP_016869247 (OMIM: 605030) PREDICTED: serine/thre ( 456)  495 54.9 1.6e-06
NP_006272 (OMIM: 605030) serine/threonine-protein  ( 491)  495 55.0 1.6e-06
NP_001243241 (OMIM: 605030) serine/threonine-prote ( 519)  495 55.0 1.7e-06
XP_011515553 (OMIM: 605030) PREDICTED: serine/thre ( 522)  495 55.0 1.7e-06
XP_016869246 (OMIM: 605030) PREDICTED: serine/thre ( 524)  495 55.0 1.7e-06
XP_011515550 (OMIM: 605030) PREDICTED: serine/thre ( 576)  495 55.1 1.7e-06
XP_016869245 (OMIM: 605030) PREDICTED: serine/thre ( 580)  495 55.1 1.8e-06
NP_001311255 (OMIM: 300142,300558) serine/threonin ( 544)  492 54.8   2e-06
XP_016885050 (OMIM: 300142,300558) PREDICTED: seri ( 544)  492 54.8   2e-06
NP_002569 (OMIM: 300142,300558) serine/threonine-p ( 544)  492 54.8   2e-06


>>NP_005914 (OMIM: 602448) mitogen-activated protein kin  (1374 aa)
 initn: 6519 init1: 6519 opt: 9002  Z-score: 3765.0  bits: 709.1 E(85289): 5.7e-203
Smith-Waterman score: 9002; 99.8% identity (99.8% similar) in 1375 aa overlap (1-1375:1-1374)

               10        20        30        40        50        60
pF1KB3 MSTEADEGITFSVPPFAPSGFCTIPEGGICRRGGAAAVGEGEEHQLPPPPPGSFWNVESA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MSTEADEGITFSVPPFAPSGFCTIPEGGICRRGGAAAVGEGEEHQLPPPPPGSFWNVESA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 AAPGIGCPAATSSSSATRGRGSSVGGGSRRTTVAYVINEASQGQLVVAESEALQSLREAC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 AAPGIGCPAATSSSSATRGRGSSVGGGSRRTTVAYVINEASQGQLVVAESEALQSLREAC
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 ETVGATLETLHFGKLDFGETTVLDRFYNADIAVVEMSDAFRQPSLFYHLGVRESFSMANN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 ETVGATLETLHFGKLDFGETTVLDRFYNADIAVVEMSDAFRQPSLFYHLGVRESFSMANN
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 IILYCDTNSDSLQSLKEIICQKNTMCTGNYTFVPYMITPHNKVYCCDSSFMKGLTELMQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 IILYCDTNSDSLQSLKEIICQKNTMCTGNYTFVPYMITPHNKVYCCDSSFMKGLTELMQP
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 NFELLLGPICLPLVDRFIQLLKVAQASSSQYFRESILNDIRKARNLYTGKELAAELARIR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 NFELLLGPICLPLVDRFIQLLKVAQASSSQYFRESILNDIRKARNLYTGKELAAELARIR
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 QRVDNIEVLTADIVINLLLSYRDIQDYDSIVKLVETLEKLPTFDLASHHHVKFHYAFALN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 QRVDNIEVLTADIVINLLLSYRDIQDYDSIVKLVETLEKLPTFDLASHHHVKFHYAFALN
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 RRNLPGDRAKALDIMIPMVQSEGQVASDMYCLVGRIYKDMFLDSNFTDTESRDHGASWFK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 RRNLPGDRAKALDIMIPMVQSEGQVASDMYCLVGRIYKDMFLDSNFTDTESRDHGASWFK
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 KAFESEPTLQSGINYAVLLLAAGHQFESSFELRKVGVKLSSLLGKKGNLEKLQSYWEVGF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 KAFESEPTLQSGINYAVLLLAAGHQFESSFELRKVGVKLSSLLGKKGNLEKLQSYWEVGF
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB3 FLGASVLANDHMRVIQASEKLFKLKTPAWYLKSIVETILIYKHFVKLTTEQPVAKQELVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 FLGASVLANDHMRVIQASEKLFKLKTPAWYLKSIVETILIYKHFVKLTTEQPVAKQELVD
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB3 FWMDFLVEATKTDVTVVRFPVLILEPTKIYQPSYLSINNEVEEKTISIWHVLPDDKKGIH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 FWMDFLVEATKTDVTVVRFPVLILEPTKIYQPSYLSINNEVEEKTISIWHVLPDDKKGIH
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB3 EWNFSASSVRGVSISKFEERCCFLYVLHNSDDFQIYFCTEPDCKKFFEMVNTITEEKGRS
       ::::::::::::::::::::::::::::::::::::::::  ::::::::::::::::::
NP_005 EWNFSASSVRGVSISKFEERCCFLYVLHNSDDFQIYFCTELHCKKFFEMVNTITEEKGRS
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB3 TEEGDCESDLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 TEEGDCESDLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQ
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB3 PLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTI
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB3 GFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFT
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB3 GTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVH
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KB3 PEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKKKKTQPKLSALSAGSNE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKKKKTQPKLSALSAGSNE
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KB3 YLRSISLPVPVLVEDTSSSSEYGSVSPDDTELKVDPFSFKTRAKSCGERDVKGIRTLFLG
       :::::::::::::::::::::::::::: :::::::::::::::::::::::::::::::
NP_005 YLRSISLPVPVLVEDTSSSSEYGSVSPD-TELKVDPFSFKTRAKSCGERDVKGIRTLFLG
              970       980        990      1000      1010         

             1030      1040      1050      1060      1070      1080
pF1KB3 IPDENFEDHSAPPSPEEKDSGFFMLRKDSERRATLHRILTEDQDKIVRNLMESLAQGAEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 IPDENFEDHSAPPSPEEKDSGFFMLRKDSERRATLHRILTEDQDKIVRNLMESLAQGAEE
    1020      1030      1040      1050      1060      1070         

             1090      1100      1110      1120      1130      1140
pF1KB3 PKLKWEHITTLIASLREFVRSTDRKIIATTLSKLKLELDFDSHGISQVQVVLFGFQDAVN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PKLKWEHITTLIASLREFVRSTDRKIIATTLSKLKLELDFDSHGISQVQVVLFGFQDAVN
    1080      1090      1100      1110      1120      1130         

             1150      1160      1170      1180      1190      1200
pF1KB3 KVLRNHNIKPHWMFALDSIIRKAVQTAITILVPELRPHFSLASESDTADQEDLDVEDDHE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 KVLRNHNIKPHWMFALDSIIRKAVQTAITILVPELRPHFSLASESDTADQEDLDVEDDHE
    1140      1150      1160      1170      1180      1190         

             1210      1220      1230      1240      1250      1260
pF1KB3 EQPSNQTVRRPQAVIEDAVATSGVSTLSSTVSHDSQSAHRSLNVQLGRMKIETNRLLEEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 EQPSNQTVRRPQAVIEDAVATSGVSTLSSTVSHDSQSAHRSLNVQLGRMKIETNRLLEEL
    1200      1210      1220      1230      1240      1250         

             1270      1280      1290      1300      1310      1320
pF1KB3 VRKEKELQALLHRAIEEKDQEIKHLKLKSQPIEIPELPVFHLNSSGTNTEDSELTDWLRV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VRKEKELQALLHRAIEEKDQEIKHLKLKSQPIEIPELPVFHLNSSGTNTEDSELTDWLRV
    1260      1270      1280      1290      1300      1310         

             1330      1340      1350      1360      1370     
pF1KB3 NGADEDTISRFLAEDYTLLDVLYYVTRDDLKCLRLRGGMLCTLWKAIIDFRNKQT
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 NGADEDTISRFLAEDYTLLDVLYYVTRDDLKCLRLRGGMLCTLWKAIIDFRNKQT
    1320      1330      1340      1350      1360      1370    

>>XP_016866362 (OMIM: 602448) PREDICTED: mitogen-activat  (1483 aa)
 initn: 6519 init1: 6519 opt: 9002  Z-score: 3764.7  bits: 709.1 E(85289): 5.9e-203
Smith-Waterman score: 9002; 99.8% identity (99.8% similar) in 1375 aa overlap (1-1375:110-1483)

                                             10        20        30
pF1KB3                               MSTEADEGITFSVPPFAPSGFCTIPEGGIC
                                     ::::::::::::::::::::::::::::::
XP_016 RRARSSPELWLARRCGWAGDAAAVAARPGEMSTEADEGITFSVPPFAPSGFCTIPEGGIC
      80        90       100       110       120       130         

               40        50        60        70        80        90
pF1KB3 RRGGAAAVGEGEEHQLPPPPPGSFWNVESAAAPGIGCPAATSSSSATRGRGSSVGGGSRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRGGAAAVGEGEEHQLPPPPPGSFWNVESAAAPGIGCPAATSSSSATRGRGSSVGGGSRR
     140       150       160       170       180       190         

              100       110       120       130       140       150
pF1KB3 TTVAYVINEASQGQLVVAESEALQSLREACETVGATLETLHFGKLDFGETTVLDRFYNAD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TTVAYVINEASQGQLVVAESEALQSLREACETVGATLETLHFGKLDFGETTVLDRFYNAD
     200       210       220       230       240       250         

              160       170       180       190       200       210
pF1KB3 IAVVEMSDAFRQPSLFYHLGVRESFSMANNIILYCDTNSDSLQSLKEIICQKNTMCTGNY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IAVVEMSDAFRQPSLFYHLGVRESFSMANNIILYCDTNSDSLQSLKEIICQKNTMCTGNY
     260       270       280       290       300       310         

              220       230       240       250       260       270
pF1KB3 TFVPYMITPHNKVYCCDSSFMKGLTELMQPNFELLLGPICLPLVDRFIQLLKVAQASSSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TFVPYMITPHNKVYCCDSSFMKGLTELMQPNFELLLGPICLPLVDRFIQLLKVAQASSSQ
     320       330       340       350       360       370         

              280       290       300       310       320       330
pF1KB3 YFRESILNDIRKARNLYTGKELAAELARIRQRVDNIEVLTADIVINLLLSYRDIQDYDSI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YFRESILNDIRKARNLYTGKELAAELARIRQRVDNIEVLTADIVINLLLSYRDIQDYDSI
     380       390       400       410       420       430         

              340       350       360       370       380       390
pF1KB3 VKLVETLEKLPTFDLASHHHVKFHYAFALNRRNLPGDRAKALDIMIPMVQSEGQVASDMY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKLVETLEKLPTFDLASHHHVKFHYAFALNRRNLPGDRAKALDIMIPMVQSEGQVASDMY
     440       450       460       470       480       490         

              400       410       420       430       440       450
pF1KB3 CLVGRIYKDMFLDSNFTDTESRDHGASWFKKAFESEPTLQSGINYAVLLLAAGHQFESSF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CLVGRIYKDMFLDSNFTDTESRDHGASWFKKAFESEPTLQSGINYAVLLLAAGHQFESSF
     500       510       520       530       540       550         

              460       470       480       490       500       510
pF1KB3 ELRKVGVKLSSLLGKKGNLEKLQSYWEVGFFLGASVLANDHMRVIQASEKLFKLKTPAWY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELRKVGVKLSSLLGKKGNLEKLQSYWEVGFFLGASVLANDHMRVIQASEKLFKLKTPAWY
     560       570       580       590       600       610         

              520       530       540       550       560       570
pF1KB3 LKSIVETILIYKHFVKLTTEQPVAKQELVDFWMDFLVEATKTDVTVVRFPVLILEPTKIY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKSIVETILIYKHFVKLTTEQPVAKQELVDFWMDFLVEATKTDVTVVRFPVLILEPTKIY
     620       630       640       650       660       670         

              580       590       600       610       620       630
pF1KB3 QPSYLSINNEVEEKTISIWHVLPDDKKGIHEWNFSASSVRGVSISKFEERCCFLYVLHNS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPSYLSINNEVEEKTISIWHVLPDDKKGIHEWNFSASSVRGVSISKFEERCCFLYVLHNS
     680       690       700       710       720       730         

              640       650       660       670       680       690
pF1KB3 DDFQIYFCTEPDCKKFFEMVNTITEEKGRSTEEGDCESDLLEYDYEYDENGDRVVLGKGT
       ::::::::::  ::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DDFQIYFCTELHCKKFFEMVNTITEEKGRSTEEGDCESDLLEYDYEYDENGDRVVLGKGT
     740       750       760       770       780       790         

              700       710       720       730       740       750
pF1KB3 YGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFI
     800       810       820       830       840       850         

              760       770       780       790       800       810
pF1KB3 KIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVL
     860       870       880       890       900       910         

              820       830       840       850       860       870
pF1KB3 INTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 INTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCT
     920       930       940       950       960       970         

              880       890       900       910       920       930
pF1KB3 IIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACAN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACAN
     980       990      1000      1010      1020      1030         

              940       950       960       970       980       990
pF1KB3 DLLVDEFLKVSSKKKKTQPKLSALSAGSNEYLRSISLPVPVLVEDTSSSSEYGSVSPDDT
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: :
XP_016 DLLVDEFLKVSSKKKKTQPKLSALSAGSNEYLRSISLPVPVLVEDTSSSSEYGSVSPD-T
    1040      1050      1060      1070      1080      1090         

             1000      1010      1020      1030      1040      1050
pF1KB3 ELKVDPFSFKTRAKSCGERDVKGIRTLFLGIPDENFEDHSAPPSPEEKDSGFFMLRKDSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELKVDPFSFKTRAKSCGERDVKGIRTLFLGIPDENFEDHSAPPSPEEKDSGFFMLRKDSE
     1100      1110      1120      1130      1140      1150        

             1060      1070      1080      1090      1100      1110
pF1KB3 RRATLHRILTEDQDKIVRNLMESLAQGAEEPKLKWEHITTLIASLREFVRSTDRKIIATT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRATLHRILTEDQDKIVRNLMESLAQGAEEPKLKWEHITTLIASLREFVRSTDRKIIATT
     1160      1170      1180      1190      1200      1210        

             1120      1130      1140      1150      1160      1170
pF1KB3 LSKLKLELDFDSHGISQVQVVLFGFQDAVNKVLRNHNIKPHWMFALDSIIRKAVQTAITI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSKLKLELDFDSHGISQVQVVLFGFQDAVNKVLRNHNIKPHWMFALDSIIRKAVQTAITI
     1220      1230      1240      1250      1260      1270        

             1180      1190      1200      1210      1220      1230
pF1KB3 LVPELRPHFSLASESDTADQEDLDVEDDHEEQPSNQTVRRPQAVIEDAVATSGVSTLSST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVPELRPHFSLASESDTADQEDLDVEDDHEEQPSNQTVRRPQAVIEDAVATSGVSTLSST
     1280      1290      1300      1310      1320      1330        

             1240      1250      1260      1270      1280      1290
pF1KB3 VSHDSQSAHRSLNVQLGRMKIETNRLLEELVRKEKELQALLHRAIEEKDQEIKHLKLKSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSHDSQSAHRSLNVQLGRMKIETNRLLEELVRKEKELQALLHRAIEEKDQEIKHLKLKSQ
     1340      1350      1360      1370      1380      1390        

             1300      1310      1320      1330      1340      1350
pF1KB3 PIEIPELPVFHLNSSGTNTEDSELTDWLRVNGADEDTISRFLAEDYTLLDVLYYVTRDDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PIEIPELPVFHLNSSGTNTEDSELTDWLRVNGADEDTISRFLAEDYTLLDVLYYVTRDDL
     1400      1410      1420      1430      1440      1450        

             1360      1370     
pF1KB3 KCLRLRGGMLCTLWKAIIDFRNKQT
       :::::::::::::::::::::::::
XP_016 KCLRLRGGMLCTLWKAIIDFRNKQT
     1460      1470      1480   

>>XP_016866361 (OMIM: 602448) PREDICTED: mitogen-activat  (1484 aa)
 initn: 8817 init1: 8817 opt: 8990  Z-score: 3759.7  bits: 708.2 E(85289): 1.1e-202
Smith-Waterman score: 8990; 99.7% identity (99.7% similar) in 1376 aa overlap (1-1375:110-1484)

                                             10        20        30
pF1KB3                               MSTEADEGITFSVPPFAPSGFCTIPEGGIC
                                     ::::::::::::::::::::::::::::::
XP_016 RRARSSPELWLARRCGWAGDAAAVAARPGEMSTEADEGITFSVPPFAPSGFCTIPEGGIC
      80        90       100       110       120       130         

               40        50        60        70        80        90
pF1KB3 RRGGAAAVGEGEEHQLPPPPPGSFWNVESAAAPGIGCPAATSSSSATRGRGSSVGGGSRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRGGAAAVGEGEEHQLPPPPPGSFWNVESAAAPGIGCPAATSSSSATRGRGSSVGGGSRR
     140       150       160       170       180       190         

              100       110       120       130       140       150
pF1KB3 TTVAYVINEASQGQLVVAESEALQSLREACETVGATLETLHFGKLDFGETTVLDRFYNAD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TTVAYVINEASQGQLVVAESEALQSLREACETVGATLETLHFGKLDFGETTVLDRFYNAD
     200       210       220       230       240       250         

              160       170       180       190       200       210
pF1KB3 IAVVEMSDAFRQPSLFYHLGVRESFSMANNIILYCDTNSDSLQSLKEIICQKNTMCTGNY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IAVVEMSDAFRQPSLFYHLGVRESFSMANNIILYCDTNSDSLQSLKEIICQKNTMCTGNY
     260       270       280       290       300       310         

              220       230       240       250       260       270
pF1KB3 TFVPYMITPHNKVYCCDSSFMKGLTELMQPNFELLLGPICLPLVDRFIQLLKVAQASSSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TFVPYMITPHNKVYCCDSSFMKGLTELMQPNFELLLGPICLPLVDRFIQLLKVAQASSSQ
     320       330       340       350       360       370         

              280       290       300       310       320       330
pF1KB3 YFRESILNDIRKARNLYTGKELAAELARIRQRVDNIEVLTADIVINLLLSYRDIQDYDSI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YFRESILNDIRKARNLYTGKELAAELARIRQRVDNIEVLTADIVINLLLSYRDIQDYDSI
     380       390       400       410       420       430         

              340       350       360       370       380       390
pF1KB3 VKLVETLEKLPTFDLASHHHVKFHYAFALNRRNLPGDRAKALDIMIPMVQSEGQVASDMY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKLVETLEKLPTFDLASHHHVKFHYAFALNRRNLPGDRAKALDIMIPMVQSEGQVASDMY
     440       450       460       470       480       490         

              400       410       420       430       440       450
pF1KB3 CLVGRIYKDMFLDSNFTDTESRDHGASWFKKAFESEPTLQSGINYAVLLLAAGHQFESSF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CLVGRIYKDMFLDSNFTDTESRDHGASWFKKAFESEPTLQSGINYAVLLLAAGHQFESSF
     500       510       520       530       540       550         

              460       470       480       490       500       510
pF1KB3 ELRKVGVKLSSLLGKKGNLEKLQSYWEVGFFLGASVLANDHMRVIQASEKLFKLKTPAWY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELRKVGVKLSSLLGKKGNLEKLQSYWEVGFFLGASVLANDHMRVIQASEKLFKLKTPAWY
     560       570       580       590       600       610         

              520       530       540       550       560       570
pF1KB3 LKSIVETILIYKHFVKLTTEQPVAKQELVDFWMDFLVEATKTDVTVVRFPVLILEPTKIY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKSIVETILIYKHFVKLTTEQPVAKQELVDFWMDFLVEATKTDVTVVRFPVLILEPTKIY
     620       630       640       650       660       670         

              580       590       600       610       620       630
pF1KB3 QPSYLSINNEVEEKTISIWHVLPDDKKGIHEWNFSASSVRGVSISKFEERCCFLYVLHNS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPSYLSINNEVEEKTISIWHVLPDDKKGIHEWNFSASSVRGVSISKFEERCCFLYVLHNS
     680       690       700       710       720       730         

              640       650       660       670       680       690
pF1KB3 DDFQIYFCTEPDCKKFFEMVNTITEEKGRSTEEGDCESDLLEYDYEYDENGDRVVLGKGT
       ::::::::::  ::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DDFQIYFCTELHCKKFFEMVNTITEEKGRSTEEGDCESDLLEYDYEYDENGDRVVLGKGT
     740       750       760       770       780       790         

              700       710       720       730       740       750
pF1KB3 YGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFI
     800       810       820       830       840       850         

              760       770       780       790       800       810
pF1KB3 KIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVL
     860       870       880       890       900       910         

              820       830       840       850       860       870
pF1KB3 INTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 INTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCT
     920       930       940       950       960       970         

              880       890       900       910       920       930
pF1KB3 IIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACAN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACAN
     980       990      1000      1010      1020      1030         

              940       950        960       970       980         
pF1KB3 DLLVDEFLKVSSKKKKTQPKLSALSAGSN-EYLRSISLPVPVLVEDTSSSSEYGSVSPDD
       ::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::: 
XP_016 DLLVDEFLKVSSKKKKTQPKLSALSAGSNAEYLRSISLPVPVLVEDTSSSSEYGSVSPD-
    1040      1050      1060      1070      1080      1090         

     990      1000      1010      1020      1030      1040         
pF1KB3 TELKVDPFSFKTRAKSCGERDVKGIRTLFLGIPDENFEDHSAPPSPEEKDSGFFMLRKDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TELKVDPFSFKTRAKSCGERDVKGIRTLFLGIPDENFEDHSAPPSPEEKDSGFFMLRKDS
     1100      1110      1120      1130      1140      1150        

    1050      1060      1070      1080      1090      1100         
pF1KB3 ERRATLHRILTEDQDKIVRNLMESLAQGAEEPKLKWEHITTLIASLREFVRSTDRKIIAT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ERRATLHRILTEDQDKIVRNLMESLAQGAEEPKLKWEHITTLIASLREFVRSTDRKIIAT
     1160      1170      1180      1190      1200      1210        

    1110      1120      1130      1140      1150      1160         
pF1KB3 TLSKLKLELDFDSHGISQVQVVLFGFQDAVNKVLRNHNIKPHWMFALDSIIRKAVQTAIT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLSKLKLELDFDSHGISQVQVVLFGFQDAVNKVLRNHNIKPHWMFALDSIIRKAVQTAIT
     1220      1230      1240      1250      1260      1270        

    1170      1180      1190      1200      1210      1220         
pF1KB3 ILVPELRPHFSLASESDTADQEDLDVEDDHEEQPSNQTVRRPQAVIEDAVATSGVSTLSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILVPELRPHFSLASESDTADQEDLDVEDDHEEQPSNQTVRRPQAVIEDAVATSGVSTLSS
     1280      1290      1300      1310      1320      1330        

    1230      1240      1250      1260      1270      1280         
pF1KB3 TVSHDSQSAHRSLNVQLGRMKIETNRLLEELVRKEKELQALLHRAIEEKDQEIKHLKLKS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TVSHDSQSAHRSLNVQLGRMKIETNRLLEELVRKEKELQALLHRAIEEKDQEIKHLKLKS
     1340      1350      1360      1370      1380      1390        

    1290      1300      1310      1320      1330      1340         
pF1KB3 QPIEIPELPVFHLNSSGTNTEDSELTDWLRVNGADEDTISRFLAEDYTLLDVLYYVTRDD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPIEIPELPVFHLNSSGTNTEDSELTDWLRVNGADEDTISRFLAEDYTLLDVLYYVTRDD
     1400      1410      1420      1430      1440      1450        

    1350      1360      1370     
pF1KB3 LKCLRLRGGMLCTLWKAIIDFRNKQT
       ::::::::::::::::::::::::::
XP_016 LKCLRLRGGMLCTLWKAIIDFRNKQT
     1460      1470      1480    

>>XP_016866360 (OMIM: 602448) PREDICTED: mitogen-activat  (1493 aa)
 initn: 6519 init1: 6519 opt: 8867  Z-score: 3708.6  bits: 698.8 E(85289): 7.8e-200
Smith-Waterman score: 8867; 99.8% identity (99.8% similar) in 1356 aa overlap (1-1356:110-1464)

                                             10        20        30
pF1KB3                               MSTEADEGITFSVPPFAPSGFCTIPEGGIC
                                     ::::::::::::::::::::::::::::::
XP_016 RRARSSPELWLARRCGWAGDAAAVAARPGEMSTEADEGITFSVPPFAPSGFCTIPEGGIC
      80        90       100       110       120       130         

               40        50        60        70        80        90
pF1KB3 RRGGAAAVGEGEEHQLPPPPPGSFWNVESAAAPGIGCPAATSSSSATRGRGSSVGGGSRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRGGAAAVGEGEEHQLPPPPPGSFWNVESAAAPGIGCPAATSSSSATRGRGSSVGGGSRR
     140       150       160       170       180       190         

              100       110       120       130       140       150
pF1KB3 TTVAYVINEASQGQLVVAESEALQSLREACETVGATLETLHFGKLDFGETTVLDRFYNAD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TTVAYVINEASQGQLVVAESEALQSLREACETVGATLETLHFGKLDFGETTVLDRFYNAD
     200       210       220       230       240       250         

              160       170       180       190       200       210
pF1KB3 IAVVEMSDAFRQPSLFYHLGVRESFSMANNIILYCDTNSDSLQSLKEIICQKNTMCTGNY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IAVVEMSDAFRQPSLFYHLGVRESFSMANNIILYCDTNSDSLQSLKEIICQKNTMCTGNY
     260       270       280       290       300       310         

              220       230       240       250       260       270
pF1KB3 TFVPYMITPHNKVYCCDSSFMKGLTELMQPNFELLLGPICLPLVDRFIQLLKVAQASSSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TFVPYMITPHNKVYCCDSSFMKGLTELMQPNFELLLGPICLPLVDRFIQLLKVAQASSSQ
     320       330       340       350       360       370         

              280       290       300       310       320       330
pF1KB3 YFRESILNDIRKARNLYTGKELAAELARIRQRVDNIEVLTADIVINLLLSYRDIQDYDSI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YFRESILNDIRKARNLYTGKELAAELARIRQRVDNIEVLTADIVINLLLSYRDIQDYDSI
     380       390       400       410       420       430         

              340       350       360       370       380       390
pF1KB3 VKLVETLEKLPTFDLASHHHVKFHYAFALNRRNLPGDRAKALDIMIPMVQSEGQVASDMY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKLVETLEKLPTFDLASHHHVKFHYAFALNRRNLPGDRAKALDIMIPMVQSEGQVASDMY
     440       450       460       470       480       490         

              400       410       420       430       440       450
pF1KB3 CLVGRIYKDMFLDSNFTDTESRDHGASWFKKAFESEPTLQSGINYAVLLLAAGHQFESSF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CLVGRIYKDMFLDSNFTDTESRDHGASWFKKAFESEPTLQSGINYAVLLLAAGHQFESSF
     500       510       520       530       540       550         

              460       470       480       490       500       510
pF1KB3 ELRKVGVKLSSLLGKKGNLEKLQSYWEVGFFLGASVLANDHMRVIQASEKLFKLKTPAWY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELRKVGVKLSSLLGKKGNLEKLQSYWEVGFFLGASVLANDHMRVIQASEKLFKLKTPAWY
     560       570       580       590       600       610         

              520       530       540       550       560       570
pF1KB3 LKSIVETILIYKHFVKLTTEQPVAKQELVDFWMDFLVEATKTDVTVVRFPVLILEPTKIY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKSIVETILIYKHFVKLTTEQPVAKQELVDFWMDFLVEATKTDVTVVRFPVLILEPTKIY
     620       630       640       650       660       670         

              580       590       600       610       620       630
pF1KB3 QPSYLSINNEVEEKTISIWHVLPDDKKGIHEWNFSASSVRGVSISKFEERCCFLYVLHNS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPSYLSINNEVEEKTISIWHVLPDDKKGIHEWNFSASSVRGVSISKFEERCCFLYVLHNS
     680       690       700       710       720       730         

              640       650       660       670       680       690
pF1KB3 DDFQIYFCTEPDCKKFFEMVNTITEEKGRSTEEGDCESDLLEYDYEYDENGDRVVLGKGT
       ::::::::::  ::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DDFQIYFCTELHCKKFFEMVNTITEEKGRSTEEGDCESDLLEYDYEYDENGDRVVLGKGT
     740       750       760       770       780       790         

              700       710       720       730       740       750
pF1KB3 YGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFI
     800       810       820       830       840       850         

              760       770       780       790       800       810
pF1KB3 KIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVL
     860       870       880       890       900       910         

              820       830       840       850       860       870
pF1KB3 INTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 INTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCT
     920       930       940       950       960       970         

              880       890       900       910       920       930
pF1KB3 IIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACAN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACAN
     980       990      1000      1010      1020      1030         

              940       950       960       970       980       990
pF1KB3 DLLVDEFLKVSSKKKKTQPKLSALSAGSNEYLRSISLPVPVLVEDTSSSSEYGSVSPDDT
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: :
XP_016 DLLVDEFLKVSSKKKKTQPKLSALSAGSNEYLRSISLPVPVLVEDTSSSSEYGSVSPD-T
    1040      1050      1060      1070      1080      1090         

             1000      1010      1020      1030      1040      1050
pF1KB3 ELKVDPFSFKTRAKSCGERDVKGIRTLFLGIPDENFEDHSAPPSPEEKDSGFFMLRKDSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELKVDPFSFKTRAKSCGERDVKGIRTLFLGIPDENFEDHSAPPSPEEKDSGFFMLRKDSE
     1100      1110      1120      1130      1140      1150        

             1060      1070      1080      1090      1100      1110
pF1KB3 RRATLHRILTEDQDKIVRNLMESLAQGAEEPKLKWEHITTLIASLREFVRSTDRKIIATT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRATLHRILTEDQDKIVRNLMESLAQGAEEPKLKWEHITTLIASLREFVRSTDRKIIATT
     1160      1170      1180      1190      1200      1210        

             1120      1130      1140      1150      1160      1170
pF1KB3 LSKLKLELDFDSHGISQVQVVLFGFQDAVNKVLRNHNIKPHWMFALDSIIRKAVQTAITI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSKLKLELDFDSHGISQVQVVLFGFQDAVNKVLRNHNIKPHWMFALDSIIRKAVQTAITI
     1220      1230      1240      1250      1260      1270        

             1180      1190      1200      1210      1220      1230
pF1KB3 LVPELRPHFSLASESDTADQEDLDVEDDHEEQPSNQTVRRPQAVIEDAVATSGVSTLSST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVPELRPHFSLASESDTADQEDLDVEDDHEEQPSNQTVRRPQAVIEDAVATSGVSTLSST
     1280      1290      1300      1310      1320      1330        

             1240      1250      1260      1270      1280      1290
pF1KB3 VSHDSQSAHRSLNVQLGRMKIETNRLLEELVRKEKELQALLHRAIEEKDQEIKHLKLKSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSHDSQSAHRSLNVQLGRMKIETNRLLEELVRKEKELQALLHRAIEEKDQEIKHLKLKSQ
     1340      1350      1360      1370      1380      1390        

             1300      1310      1320      1330      1340      1350
pF1KB3 PIEIPELPVFHLNSSGTNTEDSELTDWLRVNGADEDTISRFLAEDYTLLDVLYYVTRDDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PIEIPELPVFHLNSSGTNTEDSELTDWLRVNGADEDTISRFLAEDYTLLDVLYYVTRDDL
     1400      1410      1420      1430      1440      1450        

             1360      1370               
pF1KB3 KCLRLRGGMLCTLWKAIIDFRNKQT          
       ::::::                             
XP_016 KCLRLRYHFSFCCHYGKSTRQISKSLSIFPGWVSN
     1460      1470      1480      1490   

>>XP_016866359 (OMIM: 602448) PREDICTED: mitogen-activat  (1494 aa)
 initn: 8682 init1: 8682 opt: 8855  Z-score: 3703.7  bits: 697.8 E(85289): 1.5e-199
Smith-Waterman score: 8855; 99.7% identity (99.7% similar) in 1357 aa overlap (1-1356:110-1465)

                                             10        20        30
pF1KB3                               MSTEADEGITFSVPPFAPSGFCTIPEGGIC
                                     ::::::::::::::::::::::::::::::
XP_016 RRARSSPELWLARRCGWAGDAAAVAARPGEMSTEADEGITFSVPPFAPSGFCTIPEGGIC
      80        90       100       110       120       130         

               40        50        60        70        80        90
pF1KB3 RRGGAAAVGEGEEHQLPPPPPGSFWNVESAAAPGIGCPAATSSSSATRGRGSSVGGGSRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRGGAAAVGEGEEHQLPPPPPGSFWNVESAAAPGIGCPAATSSSSATRGRGSSVGGGSRR
     140       150       160       170       180       190         

              100       110       120       130       140       150
pF1KB3 TTVAYVINEASQGQLVVAESEALQSLREACETVGATLETLHFGKLDFGETTVLDRFYNAD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TTVAYVINEASQGQLVVAESEALQSLREACETVGATLETLHFGKLDFGETTVLDRFYNAD
     200       210       220       230       240       250         

              160       170       180       190       200       210
pF1KB3 IAVVEMSDAFRQPSLFYHLGVRESFSMANNIILYCDTNSDSLQSLKEIICQKNTMCTGNY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IAVVEMSDAFRQPSLFYHLGVRESFSMANNIILYCDTNSDSLQSLKEIICQKNTMCTGNY
     260       270       280       290       300       310         

              220       230       240       250       260       270
pF1KB3 TFVPYMITPHNKVYCCDSSFMKGLTELMQPNFELLLGPICLPLVDRFIQLLKVAQASSSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TFVPYMITPHNKVYCCDSSFMKGLTELMQPNFELLLGPICLPLVDRFIQLLKVAQASSSQ
     320       330       340       350       360       370         

              280       290       300       310       320       330
pF1KB3 YFRESILNDIRKARNLYTGKELAAELARIRQRVDNIEVLTADIVINLLLSYRDIQDYDSI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YFRESILNDIRKARNLYTGKELAAELARIRQRVDNIEVLTADIVINLLLSYRDIQDYDSI
     380       390       400       410       420       430         

              340       350       360       370       380       390
pF1KB3 VKLVETLEKLPTFDLASHHHVKFHYAFALNRRNLPGDRAKALDIMIPMVQSEGQVASDMY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKLVETLEKLPTFDLASHHHVKFHYAFALNRRNLPGDRAKALDIMIPMVQSEGQVASDMY
     440       450       460       470       480       490         

              400       410       420       430       440       450
pF1KB3 CLVGRIYKDMFLDSNFTDTESRDHGASWFKKAFESEPTLQSGINYAVLLLAAGHQFESSF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CLVGRIYKDMFLDSNFTDTESRDHGASWFKKAFESEPTLQSGINYAVLLLAAGHQFESSF
     500       510       520       530       540       550         

              460       470       480       490       500       510
pF1KB3 ELRKVGVKLSSLLGKKGNLEKLQSYWEVGFFLGASVLANDHMRVIQASEKLFKLKTPAWY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELRKVGVKLSSLLGKKGNLEKLQSYWEVGFFLGASVLANDHMRVIQASEKLFKLKTPAWY
     560       570       580       590       600       610         

              520       530       540       550       560       570
pF1KB3 LKSIVETILIYKHFVKLTTEQPVAKQELVDFWMDFLVEATKTDVTVVRFPVLILEPTKIY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKSIVETILIYKHFVKLTTEQPVAKQELVDFWMDFLVEATKTDVTVVRFPVLILEPTKIY
     620       630       640       650       660       670         

              580       590       600       610       620       630
pF1KB3 QPSYLSINNEVEEKTISIWHVLPDDKKGIHEWNFSASSVRGVSISKFEERCCFLYVLHNS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPSYLSINNEVEEKTISIWHVLPDDKKGIHEWNFSASSVRGVSISKFEERCCFLYVLHNS
     680       690       700       710       720       730         

              640       650       660       670       680       690
pF1KB3 DDFQIYFCTEPDCKKFFEMVNTITEEKGRSTEEGDCESDLLEYDYEYDENGDRVVLGKGT
       ::::::::::  ::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DDFQIYFCTELHCKKFFEMVNTITEEKGRSTEEGDCESDLLEYDYEYDENGDRVVLGKGT
     740       750       760       770       780       790         

              700       710       720       730       740       750
pF1KB3 YGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFI
     800       810       820       830       840       850         

              760       770       780       790       800       810
pF1KB3 KIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVL
     860       870       880       890       900       910         

              820       830       840       850       860       870
pF1KB3 INTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 INTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCT
     920       930       940       950       960       970         

              880       890       900       910       920       930
pF1KB3 IIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACAN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACAN
     980       990      1000      1010      1020      1030         

              940       950        960       970       980         
pF1KB3 DLLVDEFLKVSSKKKKTQPKLSALSAGSN-EYLRSISLPVPVLVEDTSSSSEYGSVSPDD
       ::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::: 
XP_016 DLLVDEFLKVSSKKKKTQPKLSALSAGSNAEYLRSISLPVPVLVEDTSSSSEYGSVSPD-
    1040      1050      1060      1070      1080      1090         

     990      1000      1010      1020      1030      1040         
pF1KB3 TELKVDPFSFKTRAKSCGERDVKGIRTLFLGIPDENFEDHSAPPSPEEKDSGFFMLRKDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TELKVDPFSFKTRAKSCGERDVKGIRTLFLGIPDENFEDHSAPPSPEEKDSGFFMLRKDS
     1100      1110      1120      1130      1140      1150        

    1050      1060      1070      1080      1090      1100         
pF1KB3 ERRATLHRILTEDQDKIVRNLMESLAQGAEEPKLKWEHITTLIASLREFVRSTDRKIIAT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ERRATLHRILTEDQDKIVRNLMESLAQGAEEPKLKWEHITTLIASLREFVRSTDRKIIAT
     1160      1170      1180      1190      1200      1210        

    1110      1120      1130      1140      1150      1160         
pF1KB3 TLSKLKLELDFDSHGISQVQVVLFGFQDAVNKVLRNHNIKPHWMFALDSIIRKAVQTAIT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLSKLKLELDFDSHGISQVQVVLFGFQDAVNKVLRNHNIKPHWMFALDSIIRKAVQTAIT
     1220      1230      1240      1250      1260      1270        

    1170      1180      1190      1200      1210      1220         
pF1KB3 ILVPELRPHFSLASESDTADQEDLDVEDDHEEQPSNQTVRRPQAVIEDAVATSGVSTLSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILVPELRPHFSLASESDTADQEDLDVEDDHEEQPSNQTVRRPQAVIEDAVATSGVSTLSS
     1280      1290      1300      1310      1320      1330        

    1230      1240      1250      1260      1270      1280         
pF1KB3 TVSHDSQSAHRSLNVQLGRMKIETNRLLEELVRKEKELQALLHRAIEEKDQEIKHLKLKS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TVSHDSQSAHRSLNVQLGRMKIETNRLLEELVRKEKELQALLHRAIEEKDQEIKHLKLKS
     1340      1350      1360      1370      1380      1390        

    1290      1300      1310      1320      1330      1340         
pF1KB3 QPIEIPELPVFHLNSSGTNTEDSELTDWLRVNGADEDTISRFLAEDYTLLDVLYYVTRDD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPIEIPELPVFHLNSSGTNTEDSELTDWLRVNGADEDTISRFLAEDYTLLDVLYYVTRDD
     1400      1410      1420      1430      1440      1450        

    1350      1360      1370               
pF1KB3 LKCLRLRGGMLCTLWKAIIDFRNKQT          
       :::::::                             
XP_016 LKCLRLRYHFSFCCHYGKSTRQISKSLSIFPGWVSN
     1460      1470      1480      1490    

>>XP_016866366 (OMIM: 602448) PREDICTED: mitogen-activat  (1181 aa)
 initn: 7523 init1: 7523 opt: 7696  Z-score: 3223.5  bits: 608.7 E(85289): 8.2e-173
Smith-Waterman score: 7696; 99.5% identity (99.7% similar) in 1182 aa overlap (195-1375:1-1181)

          170       180       190       200       210       220    
pF1KB3 LFYHLGVRESFSMANNIILYCDTNSDSLQSLKEIICQKNTMCTGNYTFVPYMITPHNKVY
                                     ..::::::::::::::::::::::::::::
XP_016                               MQEIICQKNTMCTGNYTFVPYMITPHNKVY
                                             10        20        30

          230       240       250       260       270       280    
pF1KB3 CCDSSFMKGLTELMQPNFELLLGPICLPLVDRFIQLLKVAQASSSQYFRESILNDIRKAR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CCDSSFMKGLTELMQPNFELLLGPICLPLVDRFIQLLKVAQASSSQYFRESILNDIRKAR
               40        50        60        70        80        90

          290       300       310       320       330       340    
pF1KB3 NLYTGKELAAELARIRQRVDNIEVLTADIVINLLLSYRDIQDYDSIVKLVETLEKLPTFD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NLYTGKELAAELARIRQRVDNIEVLTADIVINLLLSYRDIQDYDSIVKLVETLEKLPTFD
              100       110       120       130       140       150

          350       360       370       380       390       400    
pF1KB3 LASHHHVKFHYAFALNRRNLPGDRAKALDIMIPMVQSEGQVASDMYCLVGRIYKDMFLDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LASHHHVKFHYAFALNRRNLPGDRAKALDIMIPMVQSEGQVASDMYCLVGRIYKDMFLDS
              160       170       180       190       200       210

          410       420       430       440       450       460    
pF1KB3 NFTDTESRDHGASWFKKAFESEPTLQSGINYAVLLLAAGHQFESSFELRKVGVKLSSLLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NFTDTESRDHGASWFKKAFESEPTLQSGINYAVLLLAAGHQFESSFELRKVGVKLSSLLG
              220       230       240       250       260       270

          470       480       490       500       510       520    
pF1KB3 KKGNLEKLQSYWEVGFFLGASVLANDHMRVIQASEKLFKLKTPAWYLKSIVETILIYKHF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKGNLEKLQSYWEVGFFLGASVLANDHMRVIQASEKLFKLKTPAWYLKSIVETILIYKHF
              280       290       300       310       320       330

          530       540       550       560       570       580    
pF1KB3 VKLTTEQPVAKQELVDFWMDFLVEATKTDVTVVRFPVLILEPTKIYQPSYLSINNEVEEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKLTTEQPVAKQELVDFWMDFLVEATKTDVTVVRFPVLILEPTKIYQPSYLSINNEVEEK
              340       350       360       370       380       390

          590       600       610       620       630       640    
pF1KB3 TISIWHVLPDDKKGIHEWNFSASSVRGVSISKFEERCCFLYVLHNSDDFQIYFCTEPDCK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::  ::
XP_016 TISIWHVLPDDKKGIHEWNFSASSVRGVSISKFEERCCFLYVLHNSDDFQIYFCTELHCK
              400       410       420       430       440       450

          650       660       670       680       690       700    
pF1KB3 KFFEMVNTITEEKGRSTEEGDCESDLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KFFEMVNTITEEKGRSTEEGDCESDLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQV
              460       470       480       490       500       510

          710       720       730       740       750       760    
pF1KB3 RIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSA
              520       530       540       550       560       570

          770       780       790       800       810       820    
pF1KB3 LLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFG
              580       590       600       610       620       630

          830       840       850       860       870       880    
pF1KB3 TSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYEL
              640       650       660       670       680       690

          890       900       910       920       930       940    
pF1KB3 GEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKK
              700       710       720       730       740       750

          950        960       970       980       990      1000   
pF1KB3 KKTQPKLSALSAGSN-EYLRSISLPVPVLVEDTSSSSEYGSVSPDDTELKVDPFSFKTRA
       ::::::::::::::: ::::::::::::::::::::::::::::: ::::::::::::::
XP_016 KKTQPKLSALSAGSNAEYLRSISLPVPVLVEDTSSSSEYGSVSPD-TELKVDPFSFKTRA
              760       770       780       790        800         

          1010      1020      1030      1040      1050      1060   
pF1KB3 KSCGERDVKGIRTLFLGIPDENFEDHSAPPSPEEKDSGFFMLRKDSERRATLHRILTEDQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSCGERDVKGIRTLFLGIPDENFEDHSAPPSPEEKDSGFFMLRKDSERRATLHRILTEDQ
     810       820       830       840       850       860         

          1070      1080      1090      1100      1110      1120   
pF1KB3 DKIVRNLMESLAQGAEEPKLKWEHITTLIASLREFVRSTDRKIIATTLSKLKLELDFDSH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DKIVRNLMESLAQGAEEPKLKWEHITTLIASLREFVRSTDRKIIATTLSKLKLELDFDSH
     870       880       890       900       910       920         

          1130      1140      1150      1160      1170      1180   
pF1KB3 GISQVQVVLFGFQDAVNKVLRNHNIKPHWMFALDSIIRKAVQTAITILVPELRPHFSLAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GISQVQVVLFGFQDAVNKVLRNHNIKPHWMFALDSIIRKAVQTAITILVPELRPHFSLAS
     930       940       950       960       970       980         

          1190      1200      1210      1220      1230      1240   
pF1KB3 ESDTADQEDLDVEDDHEEQPSNQTVRRPQAVIEDAVATSGVSTLSSTVSHDSQSAHRSLN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESDTADQEDLDVEDDHEEQPSNQTVRRPQAVIEDAVATSGVSTLSSTVSHDSQSAHRSLN
     990      1000      1010      1020      1030      1040         

          1250      1260      1270      1280      1290      1300   
pF1KB3 VQLGRMKIETNRLLEELVRKEKELQALLHRAIEEKDQEIKHLKLKSQPIEIPELPVFHLN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VQLGRMKIETNRLLEELVRKEKELQALLHRAIEEKDQEIKHLKLKSQPIEIPELPVFHLN
    1050      1060      1070      1080      1090      1100         

          1310      1320      1330      1340      1350      1360   
pF1KB3 SSGTNTEDSELTDWLRVNGADEDTISRFLAEDYTLLDVLYYVTRDDLKCLRLRGGMLCTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSGTNTEDSELTDWLRVNGADEDTISRFLAEDYTLLDVLYYVTRDDLKCLRLRGGMLCTL
    1110      1120      1130      1140      1150      1160         

          1370     
pF1KB3 WKAIIDFRNKQT
       ::::::::::::
XP_016 WKAIIDFRNKQT
    1170      1180 

>>XP_011534141 (OMIM: 602448) PREDICTED: mitogen-activat  (1286 aa)
 initn: 7813 init1: 7518 opt: 7691  Z-score: 3221.1  bits: 608.3 E(85289): 1.1e-172
Smith-Waterman score: 7691; 99.6% identity (99.7% similar) in 1175 aa overlap (1-1174:110-1283)

                                             10        20        30
pF1KB3                               MSTEADEGITFSVPPFAPSGFCTIPEGGIC
                                     ::::::::::::::::::::::::::::::
XP_011 RRARSSPELWLARRCGWAGDAAAVAARPGEMSTEADEGITFSVPPFAPSGFCTIPEGGIC
      80        90       100       110       120       130         

               40        50        60        70        80        90
pF1KB3 RRGGAAAVGEGEEHQLPPPPPGSFWNVESAAAPGIGCPAATSSSSATRGRGSSVGGGSRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RRGGAAAVGEGEEHQLPPPPPGSFWNVESAAAPGIGCPAATSSSSATRGRGSSVGGGSRR
     140       150       160       170       180       190         

              100       110       120       130       140       150
pF1KB3 TTVAYVINEASQGQLVVAESEALQSLREACETVGATLETLHFGKLDFGETTVLDRFYNAD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TTVAYVINEASQGQLVVAESEALQSLREACETVGATLETLHFGKLDFGETTVLDRFYNAD
     200       210       220       230       240       250         

              160       170       180       190       200       210
pF1KB3 IAVVEMSDAFRQPSLFYHLGVRESFSMANNIILYCDTNSDSLQSLKEIICQKNTMCTGNY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IAVVEMSDAFRQPSLFYHLGVRESFSMANNIILYCDTNSDSLQSLKEIICQKNTMCTGNY
     260       270       280       290       300       310         

              220       230       240       250       260       270
pF1KB3 TFVPYMITPHNKVYCCDSSFMKGLTELMQPNFELLLGPICLPLVDRFIQLLKVAQASSSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TFVPYMITPHNKVYCCDSSFMKGLTELMQPNFELLLGPICLPLVDRFIQLLKVAQASSSQ
     320       330       340       350       360       370         

              280       290       300       310       320       330
pF1KB3 YFRESILNDIRKARNLYTGKELAAELARIRQRVDNIEVLTADIVINLLLSYRDIQDYDSI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YFRESILNDIRKARNLYTGKELAAELARIRQRVDNIEVLTADIVINLLLSYRDIQDYDSI
     380       390       400       410       420       430         

              340       350       360       370       380       390
pF1KB3 VKLVETLEKLPTFDLASHHHVKFHYAFALNRRNLPGDRAKALDIMIPMVQSEGQVASDMY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VKLVETLEKLPTFDLASHHHVKFHYAFALNRRNLPGDRAKALDIMIPMVQSEGQVASDMY
     440       450       460       470       480       490         

              400       410       420       430       440       450
pF1KB3 CLVGRIYKDMFLDSNFTDTESRDHGASWFKKAFESEPTLQSGINYAVLLLAAGHQFESSF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CLVGRIYKDMFLDSNFTDTESRDHGASWFKKAFESEPTLQSGINYAVLLLAAGHQFESSF
     500       510       520       530       540       550         

              460       470       480       490       500       510
pF1KB3 ELRKVGVKLSSLLGKKGNLEKLQSYWEVGFFLGASVLANDHMRVIQASEKLFKLKTPAWY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELRKVGVKLSSLLGKKGNLEKLQSYWEVGFFLGASVLANDHMRVIQASEKLFKLKTPAWY
     560       570       580       590       600       610         

              520       530       540       550       560       570
pF1KB3 LKSIVETILIYKHFVKLTTEQPVAKQELVDFWMDFLVEATKTDVTVVRFPVLILEPTKIY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKSIVETILIYKHFVKLTTEQPVAKQELVDFWMDFLVEATKTDVTVVRFPVLILEPTKIY
     620       630       640       650       660       670         

              580       590       600       610       620       630
pF1KB3 QPSYLSINNEVEEKTISIWHVLPDDKKGIHEWNFSASSVRGVSISKFEERCCFLYVLHNS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QPSYLSINNEVEEKTISIWHVLPDDKKGIHEWNFSASSVRGVSISKFEERCCFLYVLHNS
     680       690       700       710       720       730         

              640       650       660       670       680       690
pF1KB3 DDFQIYFCTEPDCKKFFEMVNTITEEKGRSTEEGDCESDLLEYDYEYDENGDRVVLGKGT
       ::::::::::  ::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DDFQIYFCTELHCKKFFEMVNTITEEKGRSTEEGDCESDLLEYDYEYDENGDRVVLGKGT
     740       750       760       770       780       790         

              700       710       720       730       740       750
pF1KB3 YGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFI
     800       810       820       830       840       850         

              760       770       780       790       800       810
pF1KB3 KIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVL
     860       870       880       890       900       910         

              820       830       840       850       860       870
pF1KB3 INTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 INTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCT
     920       930       940       950       960       970         

              880       890       900       910       920       930
pF1KB3 IIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACAN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACAN
     980       990      1000      1010      1020      1030         

              940       950        960       970       980         
pF1KB3 DLLVDEFLKVSSKKKKTQPKLSALSAGSN-EYLRSISLPVPVLVEDTSSSSEYGSVSPDD
       ::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::: 
XP_011 DLLVDEFLKVSSKKKKTQPKLSALSAGSNAEYLRSISLPVPVLVEDTSSSSEYGSVSPD-
    1040      1050      1060      1070      1080      1090         

     990      1000      1010      1020      1030      1040         
pF1KB3 TELKVDPFSFKTRAKSCGERDVKGIRTLFLGIPDENFEDHSAPPSPEEKDSGFFMLRKDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TELKVDPFSFKTRAKSCGERDVKGIRTLFLGIPDENFEDHSAPPSPEEKDSGFFMLRKDS
     1100      1110      1120      1130      1140      1150        

    1050      1060      1070      1080      1090      1100         
pF1KB3 ERRATLHRILTEDQDKIVRNLMESLAQGAEEPKLKWEHITTLIASLREFVRSTDRKIIAT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ERRATLHRILTEDQDKIVRNLMESLAQGAEEPKLKWEHITTLIASLREFVRSTDRKIIAT
     1160      1170      1180      1190      1200      1210        

    1110      1120      1130      1140      1150      1160         
pF1KB3 TLSKLKLELDFDSHGISQVQVVLFGFQDAVNKVLRNHNIKPHWMFALDSIIRKAVQTAIT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLSKLKLELDFDSHGISQVQVVLFGFQDAVNKVLRNHNIKPHWMFALDSIIRKAVQTAIT
     1220      1230      1240      1250      1260      1270        

    1170      1180      1190      1200      1210      1220         
pF1KB3 ILVPELRPHFSLASESDTADQEDLDVEDDHEEQPSNQTVRRPQAVIEDAVATSGVSTLSS
       ::::.                                                       
XP_011 ILVPDHIL                                                    
     1280                                                          

>>XP_016866365 (OMIM: 602448) PREDICTED: mitogen-activat  (1191 aa)
 initn: 7388 init1: 7388 opt: 7561  Z-score: 3167.4  bits: 598.3 E(85289): 1.1e-169
Smith-Waterman score: 7561; 99.5% identity (99.7% similar) in 1163 aa overlap (195-1356:1-1162)

          170       180       190       200       210       220    
pF1KB3 LFYHLGVRESFSMANNIILYCDTNSDSLQSLKEIICQKNTMCTGNYTFVPYMITPHNKVY
                                     ..::::::::::::::::::::::::::::
XP_016                               MQEIICQKNTMCTGNYTFVPYMITPHNKVY
                                             10        20        30

          230       240       250       260       270       280    
pF1KB3 CCDSSFMKGLTELMQPNFELLLGPICLPLVDRFIQLLKVAQASSSQYFRESILNDIRKAR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CCDSSFMKGLTELMQPNFELLLGPICLPLVDRFIQLLKVAQASSSQYFRESILNDIRKAR
               40        50        60        70        80        90

          290       300       310       320       330       340    
pF1KB3 NLYTGKELAAELARIRQRVDNIEVLTADIVINLLLSYRDIQDYDSIVKLVETLEKLPTFD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NLYTGKELAAELARIRQRVDNIEVLTADIVINLLLSYRDIQDYDSIVKLVETLEKLPTFD
              100       110       120       130       140       150

          350       360       370       380       390       400    
pF1KB3 LASHHHVKFHYAFALNRRNLPGDRAKALDIMIPMVQSEGQVASDMYCLVGRIYKDMFLDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LASHHHVKFHYAFALNRRNLPGDRAKALDIMIPMVQSEGQVASDMYCLVGRIYKDMFLDS
              160       170       180       190       200       210

          410       420       430       440       450       460    
pF1KB3 NFTDTESRDHGASWFKKAFESEPTLQSGINYAVLLLAAGHQFESSFELRKVGVKLSSLLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NFTDTESRDHGASWFKKAFESEPTLQSGINYAVLLLAAGHQFESSFELRKVGVKLSSLLG
              220       230       240       250       260       270

          470       480       490       500       510       520    
pF1KB3 KKGNLEKLQSYWEVGFFLGASVLANDHMRVIQASEKLFKLKTPAWYLKSIVETILIYKHF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKGNLEKLQSYWEVGFFLGASVLANDHMRVIQASEKLFKLKTPAWYLKSIVETILIYKHF
              280       290       300       310       320       330

          530       540       550       560       570       580    
pF1KB3 VKLTTEQPVAKQELVDFWMDFLVEATKTDVTVVRFPVLILEPTKIYQPSYLSINNEVEEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKLTTEQPVAKQELVDFWMDFLVEATKTDVTVVRFPVLILEPTKIYQPSYLSINNEVEEK
              340       350       360       370       380       390

          590       600       610       620       630       640    
pF1KB3 TISIWHVLPDDKKGIHEWNFSASSVRGVSISKFEERCCFLYVLHNSDDFQIYFCTEPDCK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::  ::
XP_016 TISIWHVLPDDKKGIHEWNFSASSVRGVSISKFEERCCFLYVLHNSDDFQIYFCTELHCK
              400       410       420       430       440       450

          650       660       670       680       690       700    
pF1KB3 KFFEMVNTITEEKGRSTEEGDCESDLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KFFEMVNTITEEKGRSTEEGDCESDLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQV
              460       470       480       490       500       510

          710       720       730       740       750       760    
pF1KB3 RIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSA
              520       530       540       550       560       570

          770       780       790       800       810       820    
pF1KB3 LLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFG
              580       590       600       610       620       630

          830       840       850       860       870       880    
pF1KB3 TSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYEL
              640       650       660       670       680       690

          890       900       910       920       930       940    
pF1KB3 GEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKK
              700       710       720       730       740       750

          950        960       970       980       990      1000   
pF1KB3 KKTQPKLSALSAGSN-EYLRSISLPVPVLVEDTSSSSEYGSVSPDDTELKVDPFSFKTRA
       ::::::::::::::: ::::::::::::::::::::::::::::: ::::::::::::::
XP_016 KKTQPKLSALSAGSNAEYLRSISLPVPVLVEDTSSSSEYGSVSPD-TELKVDPFSFKTRA
              760       770       780       790        800         

          1010      1020      1030      1040      1050      1060   
pF1KB3 KSCGERDVKGIRTLFLGIPDENFEDHSAPPSPEEKDSGFFMLRKDSERRATLHRILTEDQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSCGERDVKGIRTLFLGIPDENFEDHSAPPSPEEKDSGFFMLRKDSERRATLHRILTEDQ
     810       820       830       840       850       860         

          1070      1080      1090      1100      1110      1120   
pF1KB3 DKIVRNLMESLAQGAEEPKLKWEHITTLIASLREFVRSTDRKIIATTLSKLKLELDFDSH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DKIVRNLMESLAQGAEEPKLKWEHITTLIASLREFVRSTDRKIIATTLSKLKLELDFDSH
     870       880       890       900       910       920         

          1130      1140      1150      1160      1170      1180   
pF1KB3 GISQVQVVLFGFQDAVNKVLRNHNIKPHWMFALDSIIRKAVQTAITILVPELRPHFSLAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GISQVQVVLFGFQDAVNKVLRNHNIKPHWMFALDSIIRKAVQTAITILVPELRPHFSLAS
     930       940       950       960       970       980         

          1190      1200      1210      1220      1230      1240   
pF1KB3 ESDTADQEDLDVEDDHEEQPSNQTVRRPQAVIEDAVATSGVSTLSSTVSHDSQSAHRSLN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESDTADQEDLDVEDDHEEQPSNQTVRRPQAVIEDAVATSGVSTLSSTVSHDSQSAHRSLN
     990      1000      1010      1020      1030      1040         

          1250      1260      1270      1280      1290      1300   
pF1KB3 VQLGRMKIETNRLLEELVRKEKELQALLHRAIEEKDQEIKHLKLKSQPIEIPELPVFHLN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VQLGRMKIETNRLLEELVRKEKELQALLHRAIEEKDQEIKHLKLKSQPIEIPELPVFHLN
    1050      1060      1070      1080      1090      1100         

          1310      1320      1330      1340      1350      1360   
pF1KB3 SSGTNTEDSELTDWLRVNGADEDTISRFLAEDYTLLDVLYYVTRDDLKCLRLRGGMLCTL
       :::::::::::::::::::::::::::::::::::::::::::::::::::::       
XP_016 SSGTNTEDSELTDWLRVNGADEDTISRFLAEDYTLLDVLYYVTRDDLKCLRLRYHFSFCC
    1110      1120      1130      1140      1150      1160         

          1370               
pF1KB3 WKAIIDFRNKQT          
                             
XP_016 HYGKSTRQISKSLSIFPGWVSN
    1170      1180      1190 

>>XP_016866363 (OMIM: 602448) PREDICTED: mitogen-activat  (1458 aa)
 initn: 4767 init1: 4767 opt: 4940  Z-score: 2078.7  bits: 397.1 E(85289): 4.8e-109
Smith-Waterman score: 8538; 97.1% identity (97.1% similar) in 1357 aa overlap (1-1356:110-1429)

                                             10        20        30
pF1KB3                               MSTEADEGITFSVPPFAPSGFCTIPEGGIC
                                     ::::::::::::::::::::::::::::::
XP_016 RRARSSPELWLARRCGWAGDAAAVAARPGEMSTEADEGITFSVPPFAPSGFCTIPEGGIC
      80        90       100       110       120       130         

               40        50        60        70        80        90
pF1KB3 RRGGAAAVGEGEEHQLPPPPPGSFWNVESAAAPGIGCPAATSSSSATRGRGSSVGGGSRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRGGAAAVGEGEEHQLPPPPPGSFWNVESAAAPGIGCPAATSSSSATRGRGSSVGGGSRR
     140       150       160       170       180       190         

              100       110       120       130       140       150
pF1KB3 TTVAYVINEASQGQLVVAESEALQSLREACETVGATLETLHFGKLDFGETTVLDRFYNAD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TTVAYVINEASQGQLVVAESEALQSLREACETVGATLETLHFGKLDFGETTVLDRFYNAD
     200       210       220       230       240       250         

              160       170       180       190       200       210
pF1KB3 IAVVEMSDAFRQPSLFYHLGVRESFSMANNIILYCDTNSDSLQSLKEIICQKNTMCTGNY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IAVVEMSDAFRQPSLFYHLGVRESFSMANNIILYCDTNSDSLQSLKEIICQKNTMCTGNY
     260       270       280       290       300       310         

              220       230       240       250       260       270
pF1KB3 TFVPYMITPHNKVYCCDSSFMKGLTELMQPNFELLLGPICLPLVDRFIQLLKVAQASSSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TFVPYMITPHNKVYCCDSSFMKGLTELMQPNFELLLGPICLPLVDRFIQLLKVAQASSSQ
     320       330       340       350       360       370         

              280       290       300       310       320       330
pF1KB3 YFRESILNDIRKARNLYTGKELAAELARIRQRVDNIEVLTADIVINLLLSYRDIQDYDSI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YFRESILNDIRKARNLYTGKELAAELARIRQRVDNIEVLTADIVINLLLSYRDIQDYDSI
     380       390       400       410       420       430         

              340       350       360       370       380       390
pF1KB3 VKLVETLEKLPTFDLASHHHVKFHYAFALNRRNLPGDRAKALDIMIPMVQSEGQVASDMY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKLVETLEKLPTFDLASHHHVKFHYAFALNRRNLPGDRAKALDIMIPMVQSEGQVASDMY
     440       450       460       470       480       490         

              400       410       420       430       440       450
pF1KB3 CLVGRIYKDMFLDSNFTDTESRDHGASWFKKAFESEPTLQSGINYAVLLLAAGHQFESSF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CLVGRIYKDMFLDSNFTDTESRDHGASWFKKAFESEPTLQSGINYAVLLLAAGHQFESSF
     500       510       520       530       540       550         

              460       470       480       490       500       510
pF1KB3 ELRKVGVKLSSLLGKKGNLEKLQSYWEVGFFLGASVLANDHMRVIQASEKLFKLKTPAWY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELRKVGVKLSSLLGKKGNLEKLQSYWEVGFFLGASVLANDHMRVIQASEKLFKLKTPAWY
     560       570       580       590       600       610         

              520       530       540       550       560       570
pF1KB3 LKSIVETILIYKHFVKLTTEQPVAKQELVDFWMDFLVEATKTDVTVVRFPVLILEPTKIY
       ::::::::::::::::::::::::::::::::::::::::::::::::::          
XP_016 LKSIVETILIYKHFVKLTTEQPVAKQELVDFWMDFLVEATKTDVTVVRFP----------
     620       630       640       650       660                   

              580       590       600       610       620       630
pF1KB3 QPSYLSINNEVEEKTISIWHVLPDDKKGIHEWNFSASSVRGVSISKFEERCCFLYVLHNS
                                 ::::::::::::::::::::::::::::::::::
XP_016 --------------------------KGIHEWNFSASSVRGVSISKFEERCCFLYVLHNS
                               670       680       690       700   

              640       650       660       670       680       690
pF1KB3 DDFQIYFCTEPDCKKFFEMVNTITEEKGRSTEEGDCESDLLEYDYEYDENGDRVVLGKGT
       ::::::::::  ::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DDFQIYFCTELHCKKFFEMVNTITEEKGRSTEEGDCESDLLEYDYEYDENGDRVVLGKGT
           710       720       730       740       750       760   

              700       710       720       730       740       750
pF1KB3 YGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFI
           770       780       790       800       810       820   

              760       770       780       790       800       810
pF1KB3 KIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVL
           830       840       850       860       870       880   

              820       830       840       850       860       870
pF1KB3 INTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 INTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCT
           890       900       910       920       930       940   

              880       890       900       910       920       930
pF1KB3 IIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACAN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACAN
           950       960       970       980       990      1000   

              940       950        960       970       980         
pF1KB3 DLLVDEFLKVSSKKKKTQPKLSALSAGSN-EYLRSISLPVPVLVEDTSSSSEYGSVSPDD
       ::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::: 
XP_016 DLLVDEFLKVSSKKKKTQPKLSALSAGSNAEYLRSISLPVPVLVEDTSSSSEYGSVSPD-
          1010      1020      1030      1040      1050      1060   

     990      1000      1010      1020      1030      1040         
pF1KB3 TELKVDPFSFKTRAKSCGERDVKGIRTLFLGIPDENFEDHSAPPSPEEKDSGFFMLRKDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TELKVDPFSFKTRAKSCGERDVKGIRTLFLGIPDENFEDHSAPPSPEEKDSGFFMLRKDS
           1070      1080      1090      1100      1110      1120  

    1050      1060      1070      1080      1090      1100         
pF1KB3 ERRATLHRILTEDQDKIVRNLMESLAQGAEEPKLKWEHITTLIASLREFVRSTDRKIIAT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ERRATLHRILTEDQDKIVRNLMESLAQGAEEPKLKWEHITTLIASLREFVRSTDRKIIAT
           1130      1140      1150      1160      1170      1180  

    1110      1120      1130      1140      1150      1160         
pF1KB3 TLSKLKLELDFDSHGISQVQVVLFGFQDAVNKVLRNHNIKPHWMFALDSIIRKAVQTAIT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLSKLKLELDFDSHGISQVQVVLFGFQDAVNKVLRNHNIKPHWMFALDSIIRKAVQTAIT
           1190      1200      1210      1220      1230      1240  

    1170      1180      1190      1200      1210      1220         
pF1KB3 ILVPELRPHFSLASESDTADQEDLDVEDDHEEQPSNQTVRRPQAVIEDAVATSGVSTLSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILVPELRPHFSLASESDTADQEDLDVEDDHEEQPSNQTVRRPQAVIEDAVATSGVSTLSS
           1250      1260      1270      1280      1290      1300  

    1230      1240      1250      1260      1270      1280         
pF1KB3 TVSHDSQSAHRSLNVQLGRMKIETNRLLEELVRKEKELQALLHRAIEEKDQEIKHLKLKS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TVSHDSQSAHRSLNVQLGRMKIETNRLLEELVRKEKELQALLHRAIEEKDQEIKHLKLKS
           1310      1320      1330      1340      1350      1360  

    1290      1300      1310      1320      1330      1340         
pF1KB3 QPIEIPELPVFHLNSSGTNTEDSELTDWLRVNGADEDTISRFLAEDYTLLDVLYYVTRDD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPIEIPELPVFHLNSSGTNTEDSELTDWLRVNGADEDTISRFLAEDYTLLDVLYYVTRDD
           1370      1380      1390      1400      1410      1420  

    1350      1360      1370               
pF1KB3 LKCLRLRGGMLCTLWKAIIDFRNKQT          
       :::::::                             
XP_016 LKCLRLRYHFSFCCHYGKSTRQISKSLSIFPGWVSN
           1430      1440      1450        

>>NP_001001671 (OMIM: 300820) mitogen-activated protein   (1313 aa)
 initn: 3482 init1: 1755 opt: 4082  Z-score: 1723.0  bits: 331.2 E(85289): 3.1e-89
Smith-Waterman score: 5097; 58.6% identity (80.8% similar) in 1347 aa overlap (35-1374:10-1304)

           10        20        30        40        50        60    
pF1KB3 ADEGITFSVPPFAPSGFCTIPEGGICRRGGAAAVGEGEEHQLPPPPPGSFWNVESAAAPG
                                     :.:.: . :    :::::    ::.::.:.
NP_001                      MESGGGNAPAGALGAASESPQCPPPPG----VEGAAGPA
                                    10        20            30     

           70        80        90        100        110       120  
pF1KB3 IGCPAATSSSSATRGRGSSVGGGSRRTTVA-YVINEASQGQLVVA-ESEALQSLREACET
           :: ...... :.: : ::: ::.  : :: .:.:::  . . :. : : : .:::.
NP_001 EPDGAAEGAAGGS-GEGES-GGGPRRALRAVYVRSESSQGGAAGGPEAGARQCLLRACEA
          40         50         60        70        80        90   

            130       140       150       160       170       180  
pF1KB3 VGATLETLHFGKLDFGETTVLDRFYNADIAVVEMSDAFRQPSLFYHLGVRESFSMANNII
        :: : .. ::.::::::.::: ::.::.:::.:::. :::::::::::::::.::::.:
NP_001 EGAHLTSVPFGELDFGETAVLDAFYDADVAVVDMSDVSRQPSLFYHLGVRESFDMANNVI
           100       110       120       130       140       150   

            190       200       210       220       230       240  
pF1KB3 LYCDTNSDSLQSLKEIICQKNTMCTGNYTFVPYMITPHNKVYCCDSSFMKGLTELMQPNF
       :: ::..:.  :::... ::::  .::: :.::..::    .::.:. ..  .: ::::.
NP_001 LYHDTDADTALSLKDMVTQKNTASSGNYYFIPYIVTPCADYFCCESDAQRRASEYMQPNW
           160       170       180       190       200       210   

            250       260       270       280       290       300  
pF1KB3 ELLLGPICLPLVDRFIQLLKVAQASSSQYFRESILNDIRKARNLYTGKELAAELARIRQR
       . .:::.:.:::::::.:::  ...:  :..:..::::::::. : :.::: :::::. :
NP_001 DNILGPLCMPLVDRFISLLKDIHVTSCVYYKETLLNDIRKAREKYQGEELAKELARIKLR
           220       230       240       250       260       270   

            310       320       330       340       350       360  
pF1KB3 VDNIEVLTADIVINLLLSYRDIQDYDSIVKLVETLEKLPTFDLASHHHVKFHYAFALNRR
       .:: ::::.::.::::::::::::::..:::::::: ::: :::..:..:::::::::::
NP_001 MDNTEVLTSDIIINLLLSYRDIQDYDAMVKLVETLEMLPTCDLADQHNIKFHYAFALNRR
           280       290       300       310       320       330   

            370       380       390       400       410       420  
pF1KB3 NLPGDRAKALDIMIPMVQSEGQVASDMYCLVGRIYKDMFLDSNFTDTESRDHGASWFKKA
       :  ::: :::.::. ..::  . . ::.:: ::::::.::::.  :  ::: .  :..:.
NP_001 NSTGDREKALQIMLQVLQSCDHPGPDMFCLCGRIYKDIFLDSDCKDDTSRDSAIEWYRKG
           340       350       360       370       380       390   

            430       440       450       460       470       480  
pF1KB3 FESEPTLQSGINYAVLLLAAGHQFESSFELRKVGVKLSSLLGKKGNLEKLQSYWEVGFFL
       :: . .: :::: ::::..::.:::.:.::::.::.:.::::.::.:::...::.:: :.
NP_001 FELQSSLYSGINLAVLLIVAGQQFETSLELRKIGVRLNSLLGRKGSLEKMNNYWDVGQFF
           400       410       420       430       440       450   

            490       500       510       520       530       540  
pF1KB3 GASVLANDHMRVIQASEKLFKLKTPAWYLKSIVETILIYKHFVKLTTEQPVAKQELVDFW
       ..:.::.:  ...::.:.::::: :.:::.:.:...:. ..: :   :.   .:: ..::
NP_001 SVSMLAHDVGKAVQAAERLFKLKPPVWYLRSLVQNLLLIRRFKKTIIEHS-PRQERLNFW
           460       470       480       490       500        510  

            550       560       570       580       590       600  
pF1KB3 MDFLVEATKTDVTVVRFPVLILEPTKIYQPSYLSINNEVEEKTISIWHVLPDDKKGIHEW
       .:.. :::.  .. .:::::..::::.:::::.:::::.::.:.:.::: : . : .:::
NP_001 LDIIFEATNEVTNGLRFPVLVIEPTKVYQPSYVSINNEAEERTVSLWHVSPTEMKQMHEW
            520       530       540       550       560       570  

            610       620       630       640       650        660 
pF1KB3 NFSASSVRGVSISKFEERCCFLYVLHNSDDFQIYFCTEPDCKKFFEMVNT-ITEEKGRST
       ::.:::..:.:.:::.::::::::  ::::::::: :: .:..:: .:.  ::.  : ..
NP_001 NFTASSIKGISLSKFDERCCFLYVHDNSDDFQIYFSTEEQCSRFFSLVKEMITNTAGSTV
            580       590       600       610       620       630  

              670       680       690       700       710       720
pF1KB3 E-EGDCESDLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQ
       : ::. ..: :::.:..: ::.::::::::::::::::::::::::::::::::::::::
NP_001 ELEGETDGDTLEYEYDHDANGERVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQ
            640       650       660       670       680       690  

              730       740       750       760       770       780
pF1KB3 PLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTI
       ::::::::::.:::.:::::::: ::::.:::::::::::::::::::::::.:  : ::
NP_001 PLHEEIALHKYLKHRNIVQYLGSVSENGYIKIFMEQVPGGSLSALLRSKWGPMK--EPTI
            700       710       720       730       740         750

              790       800       810       820       830       840
pF1KB3 GFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFT
        ::::::::::::::.::::::::::::::.::::::.:::::::::::::.::::::::
NP_001 KFYTKQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLAGVNPCTETFT
              760       770       780       790       800       810

              850       860       870       880       890       900
pF1KB3 GTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVH
       ::::::::::::.::::::  :::::::::::::::.::::.::::::::::::::::.:
NP_001 GTLQYMAPEIIDQGPRGYGAPADIWSLGCTIIEMATSKPPFHELGEPQAAMFKVGMFKIH
              820       830       840       850       860       870

              910       920       930       940       950       960
pF1KB3 PEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKKKKTQPKLSALSAGSNE
       :::::..::::.::::.:::::: ::: . .:: . ::.  .: ::..     ..   .:
NP_001 PEIPEALSAEARAFILSCFEPDPHKRATTAELLREGFLRQVNKGKKNR-----IAFKPSE
              880       890       900       910            920     

              970        980       990      1000      1010         
pF1KB3 YLRSISLPVPVLVED-TSSSSEYGSVSPDDTELKVDPFSFKTRAKSCGERDVKGIRTLFL
         :.. : .:.  :  ..::::.:::::: .. . : .  .:::     :   :    .:
NP_001 GPRGVVLALPTQGEPMATSSSEHGSVSPD-SDAQPDALFERTRA----PRHHLG---HLL
         930       940       950        960           970          

    1020        1030      1040      1050      1060      1070       
pF1KB3 GIPDEN--FEDHSAPPSPEEKDSGFFMLRKDSERRATLHRILTEDQDKIVRNLMESLAQG
       ..:::.  .::..   :::..:.:.:.::::::::: :..:: :.:.... ::.: .::.
NP_001 SVPDESSALEDRGLASSPEDRDQGLFLLRKDSERRAILYKILWEEQNQVASNLQECVAQS
       980       990      1000      1010      1020      1030       

      1080      1090      1100      1110      1120      1130       
pF1KB3 AEEPKLKWEHITTLIASLREFVRSTDRKIIATTLSKLKLELDFDSHGISQVQVVLFGFQD
       .:: .:.  ::  .:. ::.:.:: .....:::.::::..::::: .:::...:::::::
NP_001 SEELHLSVGHIKQIIGILRDFIRSPEHRVMATTISKLKVDLDFDSSSISQIHLVLFGFQD
      1040      1050      1060      1070      1080      1090       

      1140      1150      1160      1170      1180      1190       
pF1KB3 AVNKVLRNHNIKPHWMFALDSIIRKAVQTAITILVPELRPHFSLASESDTADQEDLDVED
       ::::.:::: :.::::::.:.:::.:::.:.:::.:::: ::  . :.. .:.   :...
NP_001 AVNKILRNHLIRPHWMFAMDNIIRRAVQAAVTILIPELRAHFEPTCETEGVDK---DMDE
      1100      1110      1120      1130      1140      1150       

      1200      1210      1220      1230      1240      1250       
pF1KB3 DHEEQPSNQTVRRPQAVIEDAVATSGVSTLSSTVSHDSQSAHRSLNVQLGRMKIETNRLL
        .:  :       :                ..  ....:  .. :..:::... ::::::
NP_001 AEEGYP-------P----------------ATGPGQEAQPHQQHLSLQLGELRQETNRLL
         1160                             1170      1180      1190 

      1260      1270      1280      1290      1300      1310       
pF1KB3 EELVRKEKELQALLHRAIEEKDQEIKHLKLKSQPIEIPELPVFHLNSSGTNTEDSELTDW
       :.::.::.: : ::....:.: ::. ::.:: .   : : :.   .  :  : :.:: ::
NP_001 EHLVEKEREYQNLLRQTLEQKTQELYHLQLKLKSNCITENPA---GPYGQRT-DKELIDW
            1200      1210      1220      1230         1240        

      1320      1330      1340      1350      1360      1370       
pF1KB3 LRVNGADEDTISRFLAEDYTLLDVLYYVTRDDLKCLRLRGGMLCTLWKAIIDFRNKQT  
       ::..:::  :: ... : ::: :.:  .:..::. ::::::.:: ::.:. ..:  :   
NP_001 LRLQGADAKTIEKIVEEGYTLSDILNEITKEDLRYLRLRGGLLCRLWSAVSQYRRAQEAS
      1250      1260      1270      1280      1290      1300       

NP_001 ETKDKA
      1310   




1375 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 13:50:07 2016 done: Thu Nov  3 13:50:09 2016
 Total Scan time: 15.160 Total Display time:  0.710

Function used was FASTA [36.3.4 Apr, 2011]
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