Result of FASTA (omim) for pF1KB3683
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB3683, 1174 aa
  1>>>pF1KB3683 1174 - 1174 aa - 1174 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.6084+/-0.000493; mu= 20.4511+/- 0.031
 mean_var=64.4669+/-13.154, 0's: 0 Z-trim(108.2): 32  B-trim: 33 in 1/51
 Lambda= 0.159737
 statistics sampled from 16274 (16287) to 16274 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.532), E-opt: 0.2 (0.191), width:  16
 Scan time: 14.510

The best scores are:                                      opt bits E(85289)
NP_000929 (OMIM: 180661) DNA-directed RNA polymera (1174) 7858 1820.7       0
NP_001290198 (OMIM: 180661) DNA-directed RNA polym (1167) 7808 1809.1       0
NP_001290197 (OMIM: 180661) DNA-directed RNA polym (1099) 7299 1691.8       0
NP_001154180 (OMIM: 607694,614366,614381) DNA-dire (1075) 1625 384.2 2.3e-105
NP_060552 (OMIM: 607694,614366,614381) DNA-directe (1133) 1625 384.2 2.4e-105
XP_016875110 (OMIM: 607694,614366,614381) PREDICTE (1024) 1099 263.0 6.9e-69
NP_001269705 (OMIM: 602000) DNA-directed RNA polym ( 924)  416 105.6 1.5e-21
NP_001269703 (OMIM: 602000) DNA-directed RNA polym ( 952)  416 105.6 1.5e-21
NP_001269708 (OMIM: 602000) DNA-directed RNA polym ( 996)  416 105.6 1.6e-21
NP_001269706 (OMIM: 602000) DNA-directed RNA polym ( 996)  416 105.6 1.6e-21
NP_001131076 (OMIM: 602000) DNA-directed RNA polym (1079)  416 105.6 1.7e-21
NP_061887 (OMIM: 602000) DNA-directed RNA polymera (1135)  416 105.6 1.8e-21
NP_001269701 (OMIM: 602000) DNA-directed RNA polym (1173)  416 105.6 1.9e-21


>>NP_000929 (OMIM: 180661) DNA-directed RNA polymerase I  (1174 aa)
 initn: 7858 init1: 7858 opt: 7858  Z-score: 9774.9  bits: 1820.7 E(85289):    0
Smith-Waterman score: 7858; 100.0% identity (100.0% similar) in 1174 aa overlap (1-1174:1-1174)

               10        20        30        40        50        60
pF1KB3 MYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 DAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 DAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTY
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 SAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLD
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 PGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTIWVSML
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 PGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTIWVSML
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 ARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFEDPEMMEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFEDPEMMEM
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 VKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVSDFCETK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVSDFCETK
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 KAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 KAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQ
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 KFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLTFASTLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 KFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLTFASTLS
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB3 HLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 HLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSP
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB3 ILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSE
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB3 VSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYSWQDLVASG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYSWQDLVASG
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB3 VVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSP
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB3 RNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIV
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB3 AIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKPTRETCQGM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 AIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKPTRETCQGM
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB3 RHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELESTNRRYTKRDCSTFLRTSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELESTNRRYTKRDCSTFLRTSE
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KB3 TGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEG
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KB3 ITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNLLSDYGY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNLLSDYGY
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KB3 HLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 HLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSR
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KB3 DGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHTYECRGC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 DGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHTYECRGC
             1090      1100      1110      1120      1130      1140

             1150      1160      1170    
pF1KB3 RNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV
       ::::::::::::::::::::::::::::::::::
NP_000 RNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV
             1150      1160      1170    

>>NP_001290198 (OMIM: 180661) DNA-directed RNA polymeras  (1167 aa)
 initn: 7808 init1: 7808 opt: 7808  Z-score: 9712.7  bits: 1809.1 E(85289):    0
Smith-Waterman score: 7808; 100.0% identity (100.0% similar) in 1167 aa overlap (8-1174:1-1167)

               10        20        30        40        50        60
pF1KB3 MYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVE
              :::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001        MQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVE
                      10        20        30        40        50   

               70        80        90       100       110       120
pF1KB3 DAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTY
            60        70        80        90       100       110   

              130       140       150       160       170       180
pF1KB3 SAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLD
           120       130       140       150       160       170   

              190       200       210       220       230       240
pF1KB3 PGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTIWVSML
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTIWVSML
           180       190       200       210       220       230   

              250       260       270       280       290       300
pF1KB3 ARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFEDPEMMEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFEDPEMMEM
           240       250       260       270       280       290   

              310       320       330       340       350       360
pF1KB3 VKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVSDFCETK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVSDFCETK
           300       310       320       330       340       350   

              370       380       390       400       410       420
pF1KB3 KAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQ
           360       370       380       390       400       410   

              430       440       450       460       470       480
pF1KB3 KFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLTFASTLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLTFASTLS
           420       430       440       450       460       470   

              490       500       510       520       530       540
pF1KB3 HLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSP
           480       490       500       510       520       530   

              550       560       570       580       590       600
pF1KB3 ILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSE
           540       550       560       570       580       590   

              610       620       630       640       650       660
pF1KB3 VSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYSWQDLVASG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYSWQDLVASG
           600       610       620       630       640       650   

              670       680       690       700       710       720
pF1KB3 VVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSP
           660       670       680       690       700       710   

              730       740       750       760       770       780
pF1KB3 RNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIV
           720       730       740       750       760       770   

              790       800       810       820       830       840
pF1KB3 AIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKPTRETCQGM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKPTRETCQGM
           780       790       800       810       820       830   

              850       860       870       880       890       900
pF1KB3 RHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELESTNRRYTKRDCSTFLRTSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELESTNRRYTKRDCSTFLRTSE
           840       850       860       870       880       890   

              910       920       930       940       950       960
pF1KB3 TGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEG
           900       910       920       930       940       950   

              970       980       990      1000      1010      1020
pF1KB3 ITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNLLSDYGY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNLLSDYGY
           960       970       980       990      1000      1010   

             1030      1040      1050      1060      1070      1080
pF1KB3 HLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSR
          1020      1030      1040      1050      1060      1070   

             1090      1100      1110      1120      1130      1140
pF1KB3 DGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHTYECRGC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHTYECRGC
          1080      1090      1100      1110      1120      1130   

             1150      1160      1170    
pF1KB3 RNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV
       ::::::::::::::::::::::::::::::::::
NP_001 RNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV
          1140      1150      1160       

>>NP_001290197 (OMIM: 180661) DNA-directed RNA polymeras  (1099 aa)
 initn: 7299 init1: 7299 opt: 7299  Z-score: 9079.2  bits: 1691.8 E(85289):    0
Smith-Waterman score: 7299; 100.0% identity (100.0% similar) in 1093 aa overlap (82-1174:7-1099)

              60        70        80        90       100       110 
pF1KB3 QMSVQRIVEDAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPN
                                     ::::::::::::::::::::::::::::::
NP_001                         MLDCNQPRYLLKFEQIYLSKPTHWERDGAPSPMMPN
                                       10        20        30      

             120       130       140       150       160       170 
pF1KB3 EARLRNLTYSAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EARLRNLTYSAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDL
         40        50        60        70        80        90      

             180       190       200       210       220       230 
pF1KB3 CELNECPLDPGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CELNECPLDPGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRP
        100       110       120       130       140       150      

             240       250       260       270       280       290 
pF1KB3 TSTIWVSMLARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TSTIWVSMLARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYD
        160       170       180       190       200       210      

             300       310       320       330       340       350 
pF1KB3 FEDPEMMEMVKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FEDPEMMEMVKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHV
        220       230       240       250       260       270      

             360       370       380       390       400       410 
pF1KB3 GVSDFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVSDFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNL
        280       290       300       310       320       330      

             420       430       440       450       460       470 
pF1KB3 LKEVRIYAQKFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKEVRIYAQKFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLN
        340       350       360       370       380       390      

             480       490       500       510       520       530 
pF1KB3 RLTFASTLSHLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLTFASTLSHLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAY
        400       410       420       430       440       450      

             540       550       560       570       580       590 
pF1KB3 ISVGSQPSPILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISVGSQPSPILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLR
        460       470       480       490       500       510      

             600       610       620       630       640       650 
pF1KB3 RQMDIIVSEVSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RQMDIIVSEVSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNY
        520       530       540       550       560       570      

             660       670       680       690       700       710 
pF1KB3 SWQDLVASGVVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASII
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SWQDLVASGVVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASII
        580       590       600       610       620       630      

             720       730       740       750       760       770 
pF1KB3 PFPDHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PFPDHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRE
        640       650       660       670       680       690      

             780       790       800       810       820       830 
pF1KB3 LPAGINSIVAIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPAGINSIVAIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEK
        700       710       720       730       740       750      

             840       850       860       870       880       890 
pF1KB3 PTRETCQGMRHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELESTNRRYTKRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PTRETCQGMRHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELESTNRRYTKRD
        760       770       780       790       800       810      

             900       910       920       930       940       950 
pF1KB3 CSTFLRTSETGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CSTFLRTSETGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQ
        820       830       840       850       860       870      

             960       970       980       990      1000      1010 
pF1KB3 EDMPFTCEGITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDMPFTCEGITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKI
        880       890       900       910       920       930      

            1020      1030      1040      1050      1060      1070 
pF1KB3 SNLLSDYGYHLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SNLLSDYGYHLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILN
        940       950       960       970       980       990      

            1080      1090      1100      1110      1120      1130 
pF1KB3 RQPMEGRSRDGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RQPMEGRSRDGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTR
       1000      1010      1020      1030      1040      1050      

            1140      1150      1160      1170    
pF1KB3 THTYECRGCRNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV
       :::::::::::::::::::::::::::::::::::::::::::
NP_001 THTYECRGCRNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV
       1060      1070      1080      1090         

>>NP_001154180 (OMIM: 607694,614366,614381) DNA-directed  (1075 aa)
 initn: 2121 init1: 802 opt: 1625  Z-score: 2012.6  bits: 384.2 E(85289): 2.3e-105
Smith-Waterman score: 2618; 39.4% identity (69.2% similar) in 1109 aa overlap (82-1171:13-1068)

              60        70        80        90       100       110 
pF1KB3 QMSVQRIVEDAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPN
                                     : . ::. .::.. :   :  ..  :. :.
NP_001                   MKANEKVTSDADPMWYLKYLNIYVGLPDVEESFNVTRPVSPH
                                 10        20        30        40  

             120       130       140       150       160       170 
pF1KB3 EARLRNLTYSAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDL
       : :::..:::::. :::  :   .: ...   ..   ::..::::::. :.:.: :  ..
NP_001 ECRLRDMTYSAPITVDIEYT---RGSQRII--RNALPIGRMPIMLRSSNCVLTGKTPAEF
             50        60             70        80        90       

             180       190       200       210       220        230
pF1KB3 CELNECPLDPGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCL-ENSSR
        .:::::::::::::..: :::.. ::... : . : :  : : :  .   :   :..::
NP_001 AKLNECPLDPGGYFIVKGVEKVILIQEQLSKNRIIVEA--DRKGAVGASVTSSTHEKKSR
       100       110       120       130         140       150     

              240       250       260       270       280       290
pF1KB3 PTSTIWVSMLARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIY
             ..: .. :          :.      .....::.:.:.:.:  ::..:.. :  
NP_001 ------TNMAVKQG----------RFYLRHNTLSEDIPIVIIFKAMGVESDQEIVQMIG-
               160                 170       180       190         

              300       310         320           330       340    
pF1KB3 DFEDPEMMEMVKPSLDEAFVIQ--EQNVALNFIGSRGAKP----GVTKEKRIKYAKEVLQ
          . ..:    :::.:    :   :  ::..::..  .     :  :. .:. :.:.: 
NP_001 --TEEHVMAAFGPSLEECQKAQIFTQMQALKYIGNKVRRQRMWGGGPKKTKIEEARELLA
        200       210       220       230       240       250      

          350       360       370       380       390       400    
pF1KB3 KEMLPHVGVSDFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLF
       . .: :: :..:    :  . . ::.:..::  :  ..::::.::::::.::: ::..::
NP_001 STILTHVPVKEFNFRAKCIYTAVMVRRVILAQ-GDNKVDDRDYYGNKRLELAGQLLSLLF
        260       270       280        290       300       310     

          410       420         430       440       450       460  
pF1KB3 RGMFKNLLKEVRIYAQKFI--DRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQA
       . .::.. .:..  :.. :  .:. .:..   ..   :..:.  ...::::.  :. .. 
NP_001 EDLFKKFNSEMKKIADQVIPKQRAAQFDVVKHMRQDQITNGMVNAISTGNWS-LKRFKMD
         320       330       340       350       360        370    

            470       480       490       500       510       520  
pF1KB3 RAGVSQVLNRLTFASTLSHLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGL
       : ::.:::.::.. :.:. . :..: . .  :.. ::.:. . :::.::..::::.: ::
NP_001 RQGVTQVLSRLSYISALGMMTRISSQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEACGL
          380       390       400       410       420       430    

            530       540       550       560         570       580
pF1KB3 VKNLALMAYISVGSQPSPILEFLEEWSMENLEEISPAAIA--DATKIFVNGCWVGIHKDP
       :::::::..:..  . .::...  . ..:... .    ..  ..  .:.::  .:. .: 
NP_001 VKNLALMTHITTDMEDGPIVKLASNLGVEDVNLLCGEELSYPNVFLVFLNGNILGVIRDH
          440       450       460       470       480       490    

              590       600       610       620       630       640
pF1KB3 EQLMNTLRKLRRQMDIIVSEVSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHI
       ..:.::.: .::    :   ::.  .. .: . : .:.::.::: .::.:::  . ..:.
NP_001 KKLVNTFRLMRRA-GYINEFVSISTNLTDRCVYISSDGGRLCRPYIIVKKQKPAVTNKHM
          500        510       520       530       540       550   

              650       660       670       680       690       700
pF1KB3 DQLKEREYNNYSWQDLVASGVVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHP
       ..: .  : :.  .:..  ..:::.:. ::.   .:.    ...         :: ::.:
NP_001 EELAQG-YRNF--EDFLHESLVEYLDVNEENDCNIALYEHTINKDT-------THLEIEP
            560         570       580       590              600   

              710       720       730       740       750       760
pF1KB3 SMILGVCASIIPFPDHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVT
         .:::::..::.: :::::::::: ::::::::.   : . :.::: ..: :::::.: 
NP_001 FTLLGVCAGLIPYPHHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMVK
           610       620       630       640       650       660   

              770       780       790       800       810          
pF1KB3 TRSMEYLRFRELPAGINSIVAIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYK---EQ
       :...: ..:..:::: :. ::. ::.::. ::....:....:::: : . :.. :   ..
NP_001 TKTIELIEFEKLPAGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRCLVYKNAKCTLKR
           670       680       690       700       710       720   

       820         830       840       850       860       870     
pF1KB3 ESKKGFDQE--EVFEKPTRETCQGMRHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPE
        ... ::.    ...  ::.     :: :   :: ::. .:: .: . .:...:.  .: 
NP_001 YTNQTFDKVMGPMLDAATRKPIW--RHEI---LDADGICSPGEKVENKQVLVNKS--MPT
           730       740         750          760       770        

          880         890       900       910       920       930  
pF1KB3 -NEDELESTN--RRYTKRDCSTFLRTSETGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIG
        ..  ::..:  ..   .:     . .  . ...::.. : :   . :. .:..: :.::
NP_001 VTQIPLEGSNVPQQPQYKDVPITYKGATDSYIEKVMISSNAEDAFLIKMLLRQTRRPEIG
        780       790       800       810       820       830      

            940       950       960       970       980       990  
pF1KB3 DKFASRHGQKGTCGIQYRQEDMPFTCEGITPDIIINPHAIPSRMTIGHLIECLQGKVSAN
       :::.:::::::.::.   ::::::   :: ::::.:::..:::::.:.::: : ::... 
NP_001 DKFSSRHGQKGVCGLIVPQEDMPFCDSGICPDIIMNPHGFPSRMTVGKLIELLAGKAGVL
        840       850       860       870       880       890      

           1000      1010      1020      1030      1040      1050  
pF1KB3 KGEIGDATPFNDAVNVQKISNLLSDYGYHLRGNEVLYNGFTGRKITSQIFIGPTYYQRLK
        :..  .: :. . .:. . . :  .::.  :.. . .:.::. . . :..::.:::.::
NP_001 DGRFHYGTAFGGS-KVKDVCEDLVRHGYNYLGKDYVTSGITGEPLEAYIYFGPVYYQKLK
        900        910       920       930       940       950     

           1060      1070      1080      1090      1100      1110  
pF1KB3 HMVDDKIHSRARGPIQILNRQPMEGRSRDGGLRFGEMERDCQIAHGAAQFLRERLFEASD
       ::: ::.:.:::::  .:.::: ::::::::::.::::::: :..::...: :::. .::
NP_001 HMVLDKMHARARGPRAVLTRQPTEGRSRDGGLRLGEMERDCLIGYGASMLLLERLMISSD
         960       970       980       990      1000      1010     

           1120      1130      1140      1150      1160      1170  
pF1KB3 PYQVHVCNLCGIMAIANTRTHTYECRGCRNKTQISLVRMPYACKLLFQELMSMSIAPRMM
        ..: ::. ::...      ..  :. :... ..: .:.:::::::::::.::.: ::. 
NP_001 AFEVDVCGQCGLLG------YSGWCHYCKSSCHVSSLRIPYACKLLFQELQSMNIIPRLK
        1020            1030      1040      1050      1060         

             
pF1KB3 SV    
             
NP_001 LSKYNE
    1070     

>>NP_060552 (OMIM: 607694,614366,614381) DNA-directed RN  (1133 aa)
 initn: 2189 init1: 802 opt: 1625  Z-score: 2012.2  bits: 384.2 E(85289): 2.4e-105
Smith-Waterman score: 2692; 38.6% identity (68.6% similar) in 1167 aa overlap (24-1171:24-1126)

               10        20        30        40        50        60
pF1KB3 MYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVE
                              :  : .. ...  ::::.:..:::. ::.. ...:..
NP_060 MDVLAEEFGNLTPEQLAAPIPTVEEKWRLLPAFLKVKGLVKQHIDSFNYFINVEIKKIMK
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 DAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTY
           .  .:.           : . ::. .::.. :   :  ..  :. :.: :::..::
NP_060 ANEKVTSDAD-----------PMWYLKYLNIYVGLPDVEESFNVTRPVSPHECRLRDMTY
               70                   80        90       100         

              130       140       150       160       170       180
pF1KB3 SAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLD
       :::. :::  :   .: ...   ..   ::..::::::. :.:.: :  .. .:::::::
NP_060 SAPITVDIEYT---RGSQRII--RNALPIGRMPIMLRSSNCVLTGKTPAEFAKLNECPLD
     110       120            130       140       150       160    

              190       200       210       220        230         
pF1KB3 PGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCL-ENSSRPTSTIWVSM
       ::::::..: :::.. ::... : . : :  : : :  .   :   :..::      ..:
NP_060 PGGYFIVKGVEKVILIQEQLSKNRIIVEA--DRKGAVGASVTSSTHEKKSR------TNM
          170       180       190         200       210            

     240       250       260       270       280       290         
pF1KB3 LARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFEDPEMME
        .. :          :.      .....::.:.:.:.:  ::..:.. :     . ..: 
NP_060 AVKQG----------RFYLRHNTLSEDIPIVIIFKAMGVESDQEIVQMIG---TEEHVMA
        220                 230       240       250          260   

     300       310         320           330       340       350   
pF1KB3 MVKPSLDEAFVIQ--EQNVALNFIGSRGAKP----GVTKEKRIKYAKEVLQKEMLPHVGV
          :::.:    :   :  ::..::..  .     :  :. .:. :.:.: . .: :: :
NP_060 AFGPSLEECQKAQIFTQMQALKYIGNKVRRQRMWGGGPKKTKIEEARELLASTILTHVPV
           270       280       290       300       310       320   

           360       370       380       390       400       410   
pF1KB3 SDFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLK
       ..:    :  . . ::.:..::  :  ..::::.::::::.::: ::..::. .::.. .
NP_060 KEFNFRAKCIYTAVMVRRVILAQ-GDNKVDDRDYYGNKRLELAGQLLSLLFEDLFKKFNS
           330       340        350       360       370       380  

           420         430       440       450       460       470 
pF1KB3 EVRIYAQKFI--DRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLN
       :..  :.. :  .:. .:..   ..   :..:.  ...::::.  :. .. : ::.:::.
NP_060 EMKKIADQVIPKQRAAQFDVVKHMRQDQITNGMVNAISTGNWS-LKRFKMDRQGVTQVLS
            390       400       410       420        430       440 

             480       490       500       510       520       530 
pF1KB3 RLTFASTLSHLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAY
       ::.. :.:. . :..: . .  :.. ::.:. . :::.::..::::.: :::::::::..
NP_060 RLSYISALGMMTRISSQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEACGLVKNLALMTH
             450       460       470       480       490       500 

             540       550       560         570       580         
pF1KB3 ISVGSQPSPILEFLEEWSMENLEEISPAAIA--DATKIFVNGCWVGIHKDPEQLMNTLRK
       :..  . .::...  . ..:... .    ..  ..  .:.::  .:. .: ..:.::.: 
NP_060 ITTDMEDGPIVKLASNLGVEDVNLLCGEELSYPNVFLVFLNGNILGVIRDHKKLVNTFRL
             510       520       530       540       550       560 

     590       600       610       620       630       640         
pF1KB3 LRRQMDIIVSEVSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYN
       .::    :   ::.  .. .: . : .:.::.::: .::.:::  . ..:...: .  : 
NP_060 MRRA-GYINEFVSISTNLTDRCVYISSDGGRLCRPYIIVKKQKPAVTNKHMEELAQG-YR
              570       580       590       600       610          

     650       660       670       680       690       700         
pF1KB3 NYSWQDLVASGVVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCAS
       :.  .:..  ..:::.:. ::.   .:.    ...         :: ::.:  .:::::.
NP_060 NF--EDFLHESLVEYLDVNEENDCNIALYEHTINKDT-------THLEIEPFTLLGVCAG
     620         630       640       650              660       670

     710       720       730       740       750       760         
pF1KB3 IIPFPDHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRF
       .::.: :::::::::: ::::::::.   : . :.::: ..: :::::.: :...: ..:
NP_060 LIPYPHHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMVKTKTIELIEF
              680       690       700       710       720       730

     770       780       790       800       810          820      
pF1KB3 RELPAGINSIVAIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYK---EQESKKGFDQE
       ..:::: :. ::. ::.::. ::....:....:::: : . :.. :   .. ... ::. 
NP_060 EKLPAGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRCLVYKNAKCTLKRYTNQTFDKV
              740       750       760       770       780       790

          830       840       850       860       870        880   
pF1KB3 --EVFEKPTRETCQGMRHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPE-NEDELEST
          ...  ::.     :: :   :: ::. .:: .: . .:...:.  .:  ..  ::..
NP_060 MGPMLDAATRKPI--WRHEI---LDADGICSPGEKVENKQVLVNKS--MPTVTQIPLEGS
              800            810       820       830         840   

             890       900       910       920       930       940 
pF1KB3 N--RRYTKRDCSTFLRTSETGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQ
       :  ..   .:     . .  . ...::.. : :   . :. .:..: :.:::::.:::::
NP_060 NVPQQPQYKDVPITYKGATDSYIEKVMISSNAEDAFLIKMLLRQTRRPEIGDKFSSRHGQ
           850       860       870       880       890       900   

             950       960       970       980       990      1000 
pF1KB3 KGTCGIQYRQEDMPFTCEGITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATP
       ::.::.   ::::::   :: ::::.:::..:::::.:.::: : ::...  :..  .: 
NP_060 KGVCGLIVPQEDMPFCDSGICPDIIMNPHGFPSRMTVGKLIELLAGKAGVLDGRFHYGTA
           910       920       930       940       950       960   

            1010      1020      1030      1040      1050      1060 
pF1KB3 FNDAVNVQKISNLLSDYGYHLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHS
       :. . .:. . . :  .::.  :.. . .:.::. . . :..::.:::.::::: ::.:.
NP_060 FGGS-KVKDVCEDLVRHGYNYLGKDYVTSGITGEPLEAYIYFGPVYYQKLKHMVLDKMHA
            970       980       990      1000      1010      1020  

            1070      1080      1090      1100      1110      1120 
pF1KB3 RARGPIQILNRQPMEGRSRDGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNL
       :::::  .:.::: ::::::::::.::::::: :..::...: :::. .:: ..: ::. 
NP_060 RARGPRAVLTRQPTEGRSRDGGLRLGEMERDCLIGYGASMLLLERLMISSDAFEVDVCGQ
           1030      1040      1050      1060      1070      1080  

            1130      1140      1150      1160      1170        
pF1KB3 CGIMAIANTRTHTYECRGCRNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV    
       ::...      ..  :. :... ..: .:.:::::::::::.::.: ::.       
NP_060 CGLLG------YSGWCHYCKSSCHVSSLRIPYACKLLFQELQSMNIIPRLKLSKYNE
                 1090      1100      1110      1120      1130   

>>XP_016875110 (OMIM: 607694,614366,614381) PREDICTED: D  (1024 aa)
 initn: 1770 init1: 519 opt: 1099  Z-score: 1357.8  bits: 263.0 E(85289): 6.9e-69
Smith-Waterman score: 2166; 36.2% identity (66.2% similar) in 1057 aa overlap (24-1061:24-1022)

               10        20        30        40        50        60
pF1KB3 MYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVE
                              :  : .. ...  ::::.:..:::. ::.. ...:..
XP_016 MDVLAEEFGNLTPEQLAAPIPTVEEKWRLLPAFLKVKGLVKQHIDSFNYFINVEIKKIMK
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 DAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTY
           .  .:.           : . ::. .::.. :   :  ..  :. :.: :::..::
XP_016 ANEKVTSDAD-----------PMWYLKYLNIYVGLPDVEESFNVTRPVSPHECRLRDMTY
               70                   80        90       100         

              130       140       150       160       170       180
pF1KB3 SAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLD
       :::. :::  :   .: ...   ..   ::..::::::. :.:.: :  .. .:::::::
XP_016 SAPITVDIEYT---RGSQRII--RNALPIGRMPIMLRSSNCVLTGKTPAEFAKLNECPLD
     110       120            130       140       150       160    

              190       200       210       220        230         
pF1KB3 PGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCL-ENSSRPTSTIWVSM
       ::::::..: :::.. ::... : . : :  : : :  .   :   :..::      ..:
XP_016 PGGYFIVKGVEKVILIQEQLSKNRIIVEA--DRKGAVGASVTSSTHEKKSR------TNM
          170       180       190         200       210            

     240       250       260       270       280       290         
pF1KB3 LARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFEDPEMME
        .. :          :.      .....::.:.:.:.:  ::..:.. :     . ..: 
XP_016 AVKQG----------RFYLRHNTLSEDIPIVIIFKAMGVESDQEIVQMIG---TEEHVMA
        220                 230       240       250          260   

     300       310         320           330       340       350   
pF1KB3 MVKPSLDEAFVIQ--EQNVALNFIGSRGAKP----GVTKEKRIKYAKEVLQKEMLPHVGV
          :::.:    :   :  ::..::..  .     :  :. .:. :.:.: . .: :: :
XP_016 AFGPSLEECQKAQIFTQMQALKYIGNKVRRQRMWGGGPKKTKIEEARELLASTILTHVPV
           270       280       290       300       310       320   

           360       370       380       390       400       410   
pF1KB3 SDFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLK
       ..:    :  . . ::.:..::  :  ..::::.::::::.::: ::..::. .::.. .
XP_016 KEFNFRAKCIYTAVMVRRVILAQ-GDNKVDDRDYYGNKRLELAGQLLSLLFEDLFKKFNS
           330       340        350       360       370       380  

           420         430       440       450       460       470 
pF1KB3 EVRIYAQKFI--DRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLN
       :..  :.. :  .:. .:..   ..   :..:.  ...::::.  :. .. : ::.:::.
XP_016 EMKKIADQVIPKQRAAQFDVVKHMRQDQITNGMVNAISTGNWS-LKRFKMDRQGVTQVLS
            390       400       410       420        430       440 

             480       490       500       510       520       530 
pF1KB3 RLTFASTLSHLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAY
       ::.. :.:. . :..: . .  :.. ::.:. . :::.::..::::.: :::::::::..
XP_016 RLSYISALGMMTRISSQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEACGLVKNLALMTH
             450       460       470       480       490       500 

             540       550       560         570       580         
pF1KB3 ISVGSQPSPILEFLEEWSMENLEEISPAAIA--DATKIFVNGCWVGIHKDPEQLMNTLRK
       :..  . .::...  . ..:... .    ..  ..  .:.::  .:. .: ..:.::.: 
XP_016 ITTDMEDGPIVKLASNLGVEDVNLLCGEELSYPNVFLVFLNGNILGVIRDHKKLVNTFRL
             510       520       530       540       550       560 

     590       600       610       620       630       640         
pF1KB3 LRRQMDIIVSEVSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYN
       .::    :   ::.  .. .: . : .:.::.::: .::.:::  . ..:...: .  : 
XP_016 MRRA-GYINEFVSISTNLTDRCVYISSDGGRLCRPYIIVKKQKPAVTNKHMEELAQG-YR
              570       580       590       600       610          

     650       660       670       680       690       700         
pF1KB3 NYSWQDLVASGVVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCAS
       :.  .:..  ..:::.:. ::.   .:     : :. .   .  :: ::.:  .:::::.
XP_016 NF--EDFLHESLVEYLDVNEENDCNIA-----LYEHTIN--KDTTHLEIEPFTLLGVCAG
     620         630       640            650         660       670

     710       720       730       740       750       760         
pF1KB3 IIPFPDHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRF
       .::.: :::::::::: ::::::::.   : . :.::: ..: :::::.: :...: ..:
XP_016 LIPYPHHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMVKTKTIELIEF
              680       690       700       710       720       730

     770       780       790       800       810          820      
pF1KB3 RELPAGINSIVAIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYK---EQESKKGFDQE
       ..:::: :. ::. ::.::. ::....:....:::: : . :.. :   .. ... ::. 
XP_016 EKLPAGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRCLVYKNAKCTLKRYTNQTFDKV
              740       750       760       770       780       790

          830       840       850       860       870        880   
pF1KB3 --EVFEKPTRETCQGMRHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPE-NEDELEST
          ...  ::.     :: :   :: ::. .:: .: . .:...:.  .:  ..  ::..
XP_016 MGPMLDAATRKPI--WRHEI---LDADGICSPGEKVENKQVLVNKS--MPTVTQIPLEGS
              800            810       820       830         840   

             890       900       910       920       930       940 
pF1KB3 N--RRYTKRDCSTFLRTSETGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQ
       :  ..   .:     . .  . ...::.. : :   . :. .:..: :.:::::.:::::
XP_016 NVPQQPQYKDVPITYKGATDSYIEKVMISSNAEDAFLIKMLLRQTRRPEIGDKFSSRHGQ
           850       860       870       880       890       900   

             950       960       970       980       990      1000 
pF1KB3 KGTCGIQYRQEDMPFTCEGITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATP
       ::.::.   ::::::   :: ::::.:::..:::::.:.::: : ::...  :..  .: 
XP_016 KGVCGLIVPQEDMPFCDSGICPDIIMNPHGFPSRMTVGKLIELLAGKAGVLDGRFHYGTA
           910       920       930       940       950       960   

            1010      1020      1030      1040      1050      1060 
pF1KB3 FNDAVNVQKISNLLSDYGYHLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHS
       :. . .:. . . :  .::.  :.. . .:.:: :      .     ..  ..:: . :.
XP_016 FGGS-KVKDVCEDLVRHGYNYLGKDYVTSGITGNKAHFWPGVDQKVQNHRINLVDLREHN
            970       980       990      1000      1010      1020  

            1070      1080      1090      1100      1110      1120 
pF1KB3 RARGPIQILNRQPMEGRSRDGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNL
                                                                   
XP_016 LY                                                          
                                                                   

>>NP_001269705 (OMIM: 602000) DNA-directed RNA polymeras  (924 aa)
 initn: 1126 init1: 368 opt: 416  Z-score: 507.9  bits: 105.6 E(85289): 1.5e-21
Smith-Waterman score: 1271; 30.7% identity (57.4% similar) in 952 aa overlap (267-1171:36-921)

        240       250       260       270       280       290      
pF1KB3 VSMLARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFEDPE
                                     .:. ....::   :: .:....:   ::  
NP_001 EEHSAVNMNLHYLENGTVMLNFIYRKELFFLPLGFALKALVSFSDYQIFQELIKGKEDDS
          10        20        30        40        50        60     

             300       310       320        330       340       350
pF1KB3 MM-----EMVKPSLDEAFVIQEQNVALNFIGS-RGAKPGVTKEKRIKYAKEVLQKEMLPH
       ..     .:..  ..:.   :.:  .::..:    .: .:      . : : : ..    
NP_001 FLRNSVSQMLRIVMEEGCSTQKQ--VLNYLGECFRVKLNVPDWYPNEQAAEFLFNQC---
          70        80          90       100       110       120   

              360       370       380       390       400       410
pF1KB3 VGVSDFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKN
       . .    .:.: :.:  :...:.  : :.   :. :   :...   : :. ....  ...
NP_001 ICIHLKSNTEKFYMLCLMTRKLFALAKGECMEDNPDSLVNQEVLTPGQLFLMFLKEKLEG
              130       140       150       160       170       180

              420       430       440             450       460    
pF1KB3 LLKEVRIYAQKFIDRGKDFNLELAIKTRIISDGL------KYSLATGNWGDQKKAHQAR-
        :  ..:  .:  ..  . ...     ::.. :.      .: .::::  ..      . 
NP_001 WLVSIKIAFDKKAQK-TSVSMNTDNLMRIFTMGIDLTKPFEYLFATGNLRSKTGLGLLQD
              190        200       210       220       230         

           470       480       490          500       510       520
pF1KB3 AGVSQVLNRLTFASTLSHLRRLNSPIGRD-GKLAKP--RQLHNTLWGMVCPAETPEGHAV
       .:.  : ..:.:   :::.: ..   : : .:.     :.:    ::..::..::.:.  
NP_001 SGLCVVADKLNFIRYLSHFRCVHR--GADFAKMRTTTVRRLLPESWGFLCPVHTPDGEPC
     240       250       260         270       280       290       

               530       540       550       560       570         
pF1KB3 GLVKNL-ALMAYISVGSQPSPILEFLEEWSMENLEEISPAAIADATKIFVNGCWVG-IHK
       ::...: :.   ..     . :  .: . ..  ..     . ..   ....:  :: . :
NP_001 GLMNHLTAVCEVVTQFVYTASIPALLCNLGVTPIDGAPHRSYSECYPVLLDGVMVGWVDK
       300       310       320       330       340       350       

       580          590            600       610       620         
pF1KB3 D-PEQLMNTLRK---LRRQ-----MDIIVSEVSMIRDIREREIRIYTDAGRICRPLLIVE
       :    . ..::.   ::..     :....  ..   ..    . ..:   :. ::.    
NP_001 DLAPGIADSLRHFKVLREKRIPPWMEVVLIPMTGKPSLYPG-LFLFTTPCRLVRPV----
       360       370       380       390        400       410      

     630       640       650       660       670       680         
pF1KB3 KQKLLLKKRHIDQLKEREYNNYSWQDLVASGVVEYIDTLEEETVMLAMTPDDLQEKEVAY
        :.: : :.                        : : :.:.  . .:.  :..      .
NP_001 -QNLALGKE------------------------ELIGTMEQIFMNVAIFEDEV------F
             420                               430       440       

     690       700       710       720       730       740         
pF1KB3 CSTYTHCEIHPSMILGVCASIIPFPDHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAH
        .. :: :. :  .:.: :..::: :::::::: ::  ::::.::  . ... : :.  .
NP_001 AGVTTHQELFPHSLLSVIANFIPFSDHNQSPRNMYQCQMGKQTMGFPLLTYQDRSDNKLY
             450       460       470       480       490       500 

     750       760       770       780       790       800         
pF1KB3 VLYYPQKPLVTTRSMEYLRFRELPAGINSIVAIASYTGYNQEDSVIMNRSAVDRGFFRSV
        :  ::.:::    ..:  . . : : :.:::. :::::..::..:.:... .::: .. 
NP_001 RLQTPQSPLVRPSMYDYYDMDNYPIGTNAIVAVISYTGYDMEDAMIVNKASWERGFAHGS
             510       520       530       540       550       560 

     810         820       830        840       850       860      
pF1KB3 FYRS--YKEQESKKGFDQEEVFE-KPTRETCQGMRHAIYDKLDDDGLIAPGVRVSGDDVI
        :.:     .:. :  :.  ::  ::           . .:::::::   :....  :  
NP_001 VYKSEFIDLSEKIKQGDSSLVFGIKPGDPR-------VLQKLDDDGLPFIGAKLQYGDPY
             570       580       590              600       610    

        870       880        890       900       910          920  
pF1KB3 IGKTVTLPENEDELESTNRRY-TKRDCSTFLRTSETGIVDQVMVTLNQEG---YKFCKIR
        .       : .  ::    : .:..:          .::.. :  :. :   .:   : 
NP_001 YSYL-----NLNTGESFVMYYKSKENC----------VVDNIKVCSNDTGSGKFKCVCIT
               620       630                 640       650         

            930       940       950       960       970       980  
pF1KB3 VRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEGITPDIIINPHAIPSRMTIGHLI
       .:  : : :::::::::::::  .  .  ::::::  :..:::..:::..::::::: ::
NP_001 MRVPRNPTIGDKFASRHGQKGILSRLWPAEDMPFTESGMVPDILFNPHGFPSRMTIGMLI
     660       670       680       690       700       710         

            990      1000         1010      1020      1030         
pF1KB3 ECLQGKVSANKGEIGDATPF---NDAVNVQKISNLLSDYGYHLRGNEVLYNGFTGRKITS
       : . :: .: .:   :::::   ..   .. ....:.  ::.. :.: ::.:..: .. .
NP_001 ESMAGKSAALHGLCHDATPFIFSEENSALEYFGEMLKAAGYNFYGTERLYSGISGLELEA
     720       730       740       750       760       770         

    1040      1050      1060      1070      1080      1090         
pF1KB3 QIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSRDGGLRFGEMERDCQIAHGA
       .:::: .:::::.:::.::.. :. :  . .. ::. ::. .::.::::::::  .:::.
NP_001 DIFIGVVYYQRLRHMVSDKFQVRTTGARDRVTNQPIGGRNVQGGIRFGEMERDALLAHGT
     780       790       800       810       820       830         

    1100      1110      1120                1130      1140         
pF1KB3 AQFLRERLFEASDPYQVHVCNLCGIM----------AIANTRTHTYECRGCRNKTQISLV
       . .:..:::. ::   .:::  :: .          . .  :.. :.:  :  .  :. :
NP_001 SFLLHDRLFNCSDRSVAHVCVKCGSLLSPLLEKPPPSWSAMRNRKYNCTLCSRSDTIDTV
     840       850       860       870       880       890         

    1150      1160      1170    
pF1KB3 RMPYACKLLFQELMSMSIAPRMMSV
        .::. . .  :: .:.:  ..   
NP_001 SVPYVFRYFVAELAAMNIKVKLDVV
     900       910       920    

>>NP_001269703 (OMIM: 602000) DNA-directed RNA polymeras  (952 aa)
 initn: 1158 init1: 368 opt: 416  Z-score: 507.6  bits: 105.6 E(85289): 1.5e-21
Smith-Waterman score: 1115; 38.5% identity (62.5% similar) in 538 aa overlap (654-1171:441-949)

           630       640       650       660       670       680   
pF1KB3 PLLIVEKQKLLLKKRHIDQLKEREYNNYSWQDLVASGVVEYIDTLEEETVMLAMTPDDLQ
                                     :.: : :  : : :.:.  . .:.  :.. 
NP_001 EVVLIPMTGKPSLYPGLFLFTTPCRLVRPVQNL-ALGKEELIGTMEQIFMNVAIFEDEV-
              420       430       440        450       460         

           690       700       710       720       730       740   
pF1KB3 EKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSPRNTYQSAMGKQAMGVYITNFHVR
            . .. :: :. :  .:.: :..::: :::::::: ::  ::::.::  . ... :
NP_001 -----FAGVTTHQELFPHSLLSVIANFIPFSDHNQSPRNMYQCQMGKQTMGFPLLTYQDR
           470       480       490       500       510       520   

           750       760       770       780       790       800   
pF1KB3 MDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIVAIASYTGYNQEDSVIMNRSAVDR
        :.  . :  ::.:::    ..:  . . : : :.:::. :::::..::..:.:... .:
NP_001 SDNKLYRLQTPQSPLVRPSMYDYYDMDNYPIGTNAIVAVISYTGYDMEDAMIVNKASWER
           530       540       550       560       570       580   

           810         820       830        840       850       860
pF1KB3 GFFRSVFYRS--YKEQESKKGFDQEEVFE-KPTRETCQGMRHAIYDKLDDDGLIAPGVRV
       :: ..  :.:     .:. :  :.  ::  ::           . .:::::::   :...
NP_001 GFAHGSVYKSEFIDLSEKIKQGDSSLVFGIKPGDPR-------VLQKLDDDGLPFIGAKL
           590       600       610              620       630      

              870       880        890       900       910         
pF1KB3 SGDDVIIGKTVTLPENEDELESTNRRY-TKRDCSTFLRTSETGIVDQVMVTLNQEG---Y
       .  :   .       : .  ::    : .:..:          .::.. :  :. :   .
NP_001 QYGDPYYSYL-----NLNTGESFVMYYKSKENC----------VVDNIKVCSNDTGSGKF
        640            650       660                 670       680 

        920       930       940       950       960       970      
pF1KB3 KFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEGITPDIIINPHAIPSRM
       :   : .:  : : :::::::::::::  .  .  ::::::  :..:::..:::..::::
NP_001 KCVCITMRVPRNPTIGDKFASRHGQKGILSRLWPAEDMPFTESGMVPDILFNPHGFPSRM
             690       700       710       720       730       740 

        980       990      1000         1010      1020      1030   
pF1KB3 TIGHLIECLQGKVSANKGEIGDATPF---NDAVNVQKISNLLSDYGYHLRGNEVLYNGFT
       ::: ::: . :: .: .:   :::::   ..   .. ....:.  ::.. :.: ::.:..
NP_001 TIGMLIESMAGKSAALHGLCHDATPFIFSEENSALEYFGEMLKAAGYNFYGTERLYSGIS
             750       760       770       780       790       800 

          1040      1050      1060      1070      1080      1090   
pF1KB3 GRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSRDGGLRFGEMERDC
       : .. ..:::: .:::::.:::.::.. :. :  . .. ::. ::. .::.:::::::: 
NP_001 GLELEADIFIGVVYYQRLRHMVSDKFQVRTTGARDRVTNQPIGGRNVQGGIRFGEMERDA
             810       820       830       840       850       860 

          1100      1110      1120                1130      1140   
pF1KB3 QIAHGAAQFLRERLFEASDPYQVHVCNLCGIM----------AIANTRTHTYECRGCRNK
        .:::.. .:..:::. ::   .:::  :: .          . .  :.. :.:  :  .
NP_001 LLAHGTSFLLHDRLFNCSDRSVAHVCVKCGSLLSPLLEKPPPSWSAMRNRKYNCTLCSRS
             870       880       890       900       910       920 

          1150      1160      1170    
pF1KB3 TQISLVRMPYACKLLFQELMSMSIAPRMMSV
         :. : .::. . .  :: .:.:  ..   
NP_001 DTIDTVSVPYVFRYFVAELAAMNIKVKLDVV
             930       940       950  

>--
 initn: 158 init1: 122 opt: 229  Z-score: 274.7  bits: 62.5 E(85289): 1.5e-08
Smith-Waterman score: 229; 23.3% identity (51.6% similar) in 382 aa overlap (39-406:38-387)

       10        20        30        40        50        60        
pF1KB3 QYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVEDAPPIDLQ
                                     :.: ...::.  .. ..   :.  ::... 
NP_001 RNLPSGPSLKHLTDPSYGIPREQQKAALQELTRAHVESFNYAVHEGLGLAVQAIPPFEFA
        10        20        30        40        50        60       

       70        80        90       100        110       120       
pF1KB3 AEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERD-GAPSPMMPNEARLRNLTYSAPLYVD
        . .. :  . .            .: ::  .      . ..: : : :  :: . : .:
NP_001 FKDERISFTILDA----------VISPPTVPKGTICKEANVYPAECRGRRSTYRGKLTAD
        70        80                  90       100       110       

       130       140       150       160       170       180       
pF1KB3 ITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLDPGGYFII
       :. .:  .:   ..    : :.: .:::..:  : : .:  . : : .:   . ::::::
NP_001 INWAV--NG---ISKGIIKQFLGYVPIMVKSKLCNLRNLPPQALIEHHEEAEEMGGYFII
       120            130       140       150       160       170  

       190         200       210          220       230       240  
pF1KB3 NGSEKV--LIAQEKMATNTVYVFAKKDSK---YAYTGECRSCLENSSRPTSTIWVSMLAR
       :: :::  .. . .     ...  :  ..   :.  :    :...    .. . . .:  
NP_001 NGIEKVIRMLIMPRRNFPIAMIRPKWKTRGPGYTQYGVSMHCVREEHSAVN-MNLHYLEN
            180       190       200       210       220        230 

            250       260         270       280       290          
pF1KB3 GGQGAKKSAIGQRIVATLPYIKQE--VPIIIVFRALGFVSDRDILEHIIYDFEDPEMM--
       :            .. .. : :.   .:. ....::   :: .:....:   ::  ..  
NP_001 G-----------TVMLNFIYRKELFFLPLGFALKALVSFSDYQIFQELIKGKEDDSFLRN
                        240       250       260       270       280

         300       310       320        330       340       350    
pF1KB3 ---EMVKPSLDEAFVIQEQNVALNFIGS-RGAKPGVTKEKRIKYAKEVLQKEMLPHVGVS
          .:..  ..:.   :.:  .::..:    .: .:      . : : : ..    . . 
NP_001 SVSQMLRIVMEEGCSTQKQ--VLNYLGECFRVKLNVPDWYPNEQAAEFLFNQC---ICIH
              290         300       310       320       330        

          360       370       380       390       400       410    
pF1KB3 DFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKE
          .:.: :.:  :...:.  : :.   :. :   :...   : :. ....:        
NP_001 LKSNTEKFYMLCLMTRKLFALAKGECMEDNPDSLVNQEVLTPGQLFLMFLKGSLPLMELP
         340       350       360       370       380       390     

          420       430       440       450       460       470    
pF1KB3 VRIYAQKFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLT
                                                                   
NP_001 TDHTVLREKRIPPWMEVVLIPMTGKPSLYPGLFLFTTPCRLVRPVQNLALGKEELIGTME
         400       410       420       430       440       450     

>>NP_001269708 (OMIM: 602000) DNA-directed RNA polymeras  (996 aa)
 initn: 1185 init1: 368 opt: 416  Z-score: 507.3  bits: 105.6 E(85289): 1.6e-21
Smith-Waterman score: 1328; 29.8% identity (56.2% similar) in 1071 aa overlap (155-1171:1-993)

          130       140       150       160       170       180    
pF1KB3 YVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLDPGGY
                                     :..:  : : .:  . : : .:   . :::
NP_001                               MVKSKLCNLRNLPPQALIEHHEEAEEMGGY
                                             10        20        30

          190         200       210          220       230         
pF1KB3 FIINGSEKV--LIAQEKMATNTVYVFAKKDSK---YAYTGECRSCLENSSRPTSTIWVSM
       ::::: :::  .. . .     ...  :  ..   :.  :    :...    .. . . .
NP_001 FIINGIEKVIRMLIMPRRNFPIAMIRPKWKTRGPGYTQYGVSMHCVREEHSAVN-MNLHY
               40        50        60        70        80          

     240       250       260         270       280       290       
pF1KB3 LARGGQGAKKSAIGQRIVATLPYIKQE--VPIIIVFRALGFVSDRDILEHIIYDFEDPEM
       :  :            .. .. : :.   .:. ....::   :: .:....:   ::  .
NP_001 LENG-----------TVMLNFIYRKELFFLPLGFALKALVSFSDYQIFQELIKGKEDDSF
      90                  100       110       120       130        

            300       310       320        330       340       350 
pF1KB3 M-----EMVKPSLDEAFVIQEQNVALNFIGS-RGAKPGVTKEKRIKYAKEVLQKEMLPHV
       .     .:..  ..:.   :.:  .::..:    .: .:      . : : : ..    .
NP_001 LRNSVSQMLRIVMEEGCSTQKQ--VLNYLGECFRVKLNVPDWYPNEQAAEFLFNQC---I
      140       150       160         170       180       190      

             360       370       380       390       400       410 
pF1KB3 GVSDFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNL
        .    .:.: :.:  :...:.  : :.   :. :   :...   : :. ....  ... 
NP_001 CIHLKSNTEKFYMLCLMTRKLFALAKGECMEDNPDSLVNQEVLTPGQLFLMFLKEKLEGW
           200       210       220       230       240       250   

             420       430       440             450       460     
pF1KB3 LKEVRIYAQKFIDRGKDFNLELAIKTRIISDGL------KYSLATGNWGDQKKAHQAR-A
       :  ..:  .:  ..  . ...     ::.. :.      .: .::::  ..      . .
NP_001 LVSIKIAFDKKAQK-TSVSMNTDNLMRIFTMGIDLTKPFEYLFATGNLRSKTGLGLLQDS
           260        270       280       290       300       310  

          470       480       490          500       510       520 
pF1KB3 GVSQVLNRLTFASTLSHLRRLNSPIGRD-GKLAKP--RQLHNTLWGMVCPAETPEGHAVG
       :.  : ..:.:   :::.: ..   : : .:.     :.:    ::..::..::.:.  :
NP_001 GLCVVADKLNFIRYLSHFRCVHR--GADFAKMRTTTVRRLLPESWGFLCPVHTPDGEPCG
            320       330         340       350       360       370

              530       540       550       560       570          
pF1KB3 LVKNL-ALMAYISVGSQPSPILEFLEEWSMENLEEISPAAIADATKIFVNGCWVG-IHKD
       :...: :.   ..     . :  .: . ..  ..     . ..   ....:  :: . ::
NP_001 LMNHLTAVCEVVTQFVYTASIPALLCNLGVTPIDGAPHRSYSECYPVLLDGVMVGWVDKD
              380       390       400       410       420       430

      580          590            600       610       620       630
pF1KB3 -PEQLMNTLRK---LRRQ-----MDIIVSEVSMIRDIREREIRIYTDAGRICRPLLIVEK
           . ..::.   ::..     :....  ..   ..    . ..:   :. ::.     
NP_001 LAPGIADSLRHFKVLREKRIPPWMEVVLIPMTGKPSLYPG-LFLFTTPCRLVRPV-----
              440       450       460       470        480         

              640       650       660       670       680       690
pF1KB3 QKLLLKKRHIDQLKEREYNNYSWQDLVASGVVEYIDTLEEETVMLAMTPDDLQEKEVAYC
       :.: : :.                        : : :.:.  . .:.  :..      . 
NP_001 QNLALGKE------------------------ELIGTMEQIFMNVAIFEDEV------FA
          490                               500       510          

              700       710       720       730       740       750
pF1KB3 STYTHCEIHPSMILGVCASIIPFPDHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHV
       .. :: :. :  .:.: :..::: :::::::: ::  ::::.::  . ... : :.  . 
NP_001 GVTTHQELFPHSLLSVIANFIPFSDHNQSPRNMYQCQMGKQTMGFPLLTYQDRSDNKLYR
          520       530       540       550       560       570    

              760       770       780       790       800       810
pF1KB3 LYYPQKPLVTTRSMEYLRFRELPAGINSIVAIASYTGYNQEDSVIMNRSAVDRGFFRSVF
       :  ::.:::    ..:  . . : : :.:::. :::::..::..:.:... .::: ..  
NP_001 LQTPQSPLVRPSMYDYYDMDNYPIGTNAIVAVISYTGYDMEDAMIVNKASWERGFAHGSV
          580       590       600       610       620       630    

                820       830        840       850       860       
pF1KB3 YRS--YKEQESKKGFDQEEVFE-KPTRETCQGMRHAIYDKLDDDGLIAPGVRVSGDDVII
       :.:     .:. :  :.  ::  ::           . .:::::::   :....  :   
NP_001 YKSEFIDLSEKIKQGDSSLVFGIKPGDPR-------VLQKLDDDGLPFIGAKLQYGDPYY
          640       650       660              670       680       

       870       880        890       900       910          920   
pF1KB3 GKTVTLPENEDELESTNRRY-TKRDCSTFLRTSETGIVDQVMVTLNQEG---YKFCKIRV
       .       : .  ::    : .:..:          .::.. :  :. :   .:   : .
NP_001 SYL-----NLNTGESFVMYYKSKENC----------VVDNIKVCSNDTGSGKFKCVCITM
       690            700                 710       720       730  

           930       940       950       960       970       980   
pF1KB3 RSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEGITPDIIINPHAIPSRMTIGHLIE
       :  : : :::::::::::::  .  .  ::::::  :..:::..:::..::::::: :::
NP_001 RVPRNPTIGDKFASRHGQKGILSRLWPAEDMPFTESGMVPDILFNPHGFPSRMTIGMLIE
            740       750       760       770       780       790  

           990      1000         1010      1020      1030      1040
pF1KB3 CLQGKVSANKGEIGDATPF---NDAVNVQKISNLLSDYGYHLRGNEVLYNGFTGRKITSQ
        . :: .: .:   :::::   ..   .. ....:.  ::.. :.: ::.:..: .. ..
NP_001 SMAGKSAALHGLCHDATPFIFSEENSALEYFGEMLKAAGYNFYGTERLYSGISGLELEAD
            800       810       820       830       840       850  

             1050      1060      1070      1080      1090      1100
pF1KB3 IFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSRDGGLRFGEMERDCQIAHGAA
       :::: .:::::.:::.::.. :. :  . .. ::. ::. .::.::::::::  .:::..
NP_001 IFIGVVYYQRLRHMVSDKFQVRTTGARDRVTNQPIGGRNVQGGIRFGEMERDALLAHGTS
            860       870       880       890       900       910  

             1110      1120                1130      1140      1150
pF1KB3 QFLRERLFEASDPYQVHVCNLCGIM----------AIANTRTHTYECRGCRNKTQISLVR
        .:..:::. ::   .:::  :: .          . .  :.. :.:  :  .  :. : 
NP_001 FLLHDRLFNCSDRSVAHVCVKCGSLLSPLLEKPPPSWSAMRNRKYNCTLCSRSDTIDTVS
            920       930       940       950       960       970  

             1160      1170    
pF1KB3 MPYACKLLFQELMSMSIAPRMMSV
       .::. . .  :: .:.:  ..   
NP_001 VPYVFRYFVAELAAMNIKVKLDVV
            980       990      

>>NP_001269706 (OMIM: 602000) DNA-directed RNA polymeras  (996 aa)
 initn: 1185 init1: 368 opt: 416  Z-score: 507.3  bits: 105.6 E(85289): 1.6e-21
Smith-Waterman score: 1328; 29.8% identity (56.2% similar) in 1071 aa overlap (155-1171:1-993)

          130       140       150       160       170       180    
pF1KB3 YVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLDPGGY
                                     :..:  : : .:  . : : .:   . :::
NP_001                               MVKSKLCNLRNLPPQALIEHHEEAEEMGGY
                                             10        20        30

          190         200       210          220       230         
pF1KB3 FIINGSEKV--LIAQEKMATNTVYVFAKKDSK---YAYTGECRSCLENSSRPTSTIWVSM
       ::::: :::  .. . .     ...  :  ..   :.  :    :...    .. . . .
NP_001 FIINGIEKVIRMLIMPRRNFPIAMIRPKWKTRGPGYTQYGVSMHCVREEHSAVN-MNLHY
               40        50        60        70        80          

     240       250       260         270       280       290       
pF1KB3 LARGGQGAKKSAIGQRIVATLPYIKQE--VPIIIVFRALGFVSDRDILEHIIYDFEDPEM
       :  :            .. .. : :.   .:. ....::   :: .:....:   ::  .
NP_001 LENG-----------TVMLNFIYRKELFFLPLGFALKALVSFSDYQIFQELIKGKEDDSF
      90                  100       110       120       130        

            300       310       320        330       340       350 
pF1KB3 M-----EMVKPSLDEAFVIQEQNVALNFIGS-RGAKPGVTKEKRIKYAKEVLQKEMLPHV
       .     .:..  ..:.   :.:  .::..:    .: .:      . : : : ..    .
NP_001 LRNSVSQMLRIVMEEGCSTQKQ--VLNYLGECFRVKLNVPDWYPNEQAAEFLFNQC---I
      140       150       160         170       180       190      

             360       370       380       390       400       410 
pF1KB3 GVSDFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNL
        .    .:.: :.:  :...:.  : :.   :. :   :...   : :. ....  ... 
NP_001 CIHLKSNTEKFYMLCLMTRKLFALAKGECMEDNPDSLVNQEVLTPGQLFLMFLKEKLEGW
           200       210       220       230       240       250   

             420       430       440             450       460     
pF1KB3 LKEVRIYAQKFIDRGKDFNLELAIKTRIISDGL------KYSLATGNWGDQKKAHQAR-A
       :  ..:  .:  ..  . ...     ::.. :.      .: .::::  ..      . .
NP_001 LVSIKIAFDKKAQK-TSVSMNTDNLMRIFTMGIDLTKPFEYLFATGNLRSKTGLGLLQDS
           260        270       280       290       300       310  

          470       480       490          500       510       520 
pF1KB3 GVSQVLNRLTFASTLSHLRRLNSPIGRD-GKLAKP--RQLHNTLWGMVCPAETPEGHAVG
       :.  : ..:.:   :::.: ..   : : .:.     :.:    ::..::..::.:.  :
NP_001 GLCVVADKLNFIRYLSHFRCVHR--GADFAKMRTTTVRRLLPESWGFLCPVHTPDGEPCG
            320       330         340       350       360       370

              530       540       550       560       570          
pF1KB3 LVKNL-ALMAYISVGSQPSPILEFLEEWSMENLEEISPAAIADATKIFVNGCWVG-IHKD
       :...: :.   ..     . :  .: . ..  ..     . ..   ....:  :: . ::
NP_001 LMNHLTAVCEVVTQFVYTASIPALLCNLGVTPIDGAPHRSYSECYPVLLDGVMVGWVDKD
              380       390       400       410       420       430

      580          590            600       610       620       630
pF1KB3 -PEQLMNTLRK---LRRQ-----MDIIVSEVSMIRDIREREIRIYTDAGRICRPLLIVEK
           . ..::.   ::..     :....  ..   ..    . ..:   :. ::.     
NP_001 LAPGIADSLRHFKVLREKRIPPWMEVVLIPMTGKPSLYPG-LFLFTTPCRLVRPV-----
              440       450       460       470        480         

              640       650       660       670       680       690
pF1KB3 QKLLLKKRHIDQLKEREYNNYSWQDLVASGVVEYIDTLEEETVMLAMTPDDLQEKEVAYC
       :.: : :.                        : : :.:.  . .:.  :..      . 
NP_001 QNLALGKE------------------------ELIGTMEQIFMNVAIFEDEV------FA
          490                               500       510          

              700       710       720       730       740       750
pF1KB3 STYTHCEIHPSMILGVCASIIPFPDHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHV
       .. :: :. :  .:.: :..::: :::::::: ::  ::::.::  . ... : :.  . 
NP_001 GVTTHQELFPHSLLSVIANFIPFSDHNQSPRNMYQCQMGKQTMGFPLLTYQDRSDNKLYR
          520       530       540       550       560       570    

              760       770       780       790       800       810
pF1KB3 LYYPQKPLVTTRSMEYLRFRELPAGINSIVAIASYTGYNQEDSVIMNRSAVDRGFFRSVF
       :  ::.:::    ..:  . . : : :.:::. :::::..::..:.:... .::: ..  
NP_001 LQTPQSPLVRPSMYDYYDMDNYPIGTNAIVAVISYTGYDMEDAMIVNKASWERGFAHGSV
          580       590       600       610       620       630    

                820       830        840       850       860       
pF1KB3 YRS--YKEQESKKGFDQEEVFE-KPTRETCQGMRHAIYDKLDDDGLIAPGVRVSGDDVII
       :.:     .:. :  :.  ::  ::           . .:::::::   :....  :   
NP_001 YKSEFIDLSEKIKQGDSSLVFGIKPGDPR-------VLQKLDDDGLPFIGAKLQYGDPYY
          640       650       660              670       680       

       870       880        890       900       910          920   
pF1KB3 GKTVTLPENEDELESTNRRY-TKRDCSTFLRTSETGIVDQVMVTLNQEG---YKFCKIRV
       .       : .  ::    : .:..:          .::.. :  :. :   .:   : .
NP_001 SYL-----NLNTGESFVMYYKSKENC----------VVDNIKVCSNDTGSGKFKCVCITM
       690            700                 710       720       730  

           930       940       950       960       970       980   
pF1KB3 RSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEGITPDIIINPHAIPSRMTIGHLIE
       :  : : :::::::::::::  .  .  ::::::  :..:::..:::..::::::: :::
NP_001 RVPRNPTIGDKFASRHGQKGILSRLWPAEDMPFTESGMVPDILFNPHGFPSRMTIGMLIE
            740       750       760       770       780       790  

           990      1000         1010      1020      1030      1040
pF1KB3 CLQGKVSANKGEIGDATPF---NDAVNVQKISNLLSDYGYHLRGNEVLYNGFTGRKITSQ
        . :: .: .:   :::::   ..   .. ....:.  ::.. :.: ::.:..: .. ..
NP_001 SMAGKSAALHGLCHDATPFIFSEENSALEYFGEMLKAAGYNFYGTERLYSGISGLELEAD
            800       810       820       830       840       850  

             1050      1060      1070      1080      1090      1100
pF1KB3 IFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSRDGGLRFGEMERDCQIAHGAA
       :::: .:::::.:::.::.. :. :  . .. ::. ::. .::.::::::::  .:::..
NP_001 IFIGVVYYQRLRHMVSDKFQVRTTGARDRVTNQPIGGRNVQGGIRFGEMERDALLAHGTS
            860       870       880       890       900       910  

             1110      1120                1130      1140      1150
pF1KB3 QFLRERLFEASDPYQVHVCNLCGIM----------AIANTRTHTYECRGCRNKTQISLVR
        .:..:::. ::   .:::  :: .          . .  :.. :.:  :  .  :. : 
NP_001 FLLHDRLFNCSDRSVAHVCVKCGSLLSPLLEKPPPSWSAMRNRKYNCTLCSRSDTIDTVS
            920       930       940       950       960       970  

             1160      1170    
pF1KB3 MPYACKLLFQELMSMSIAPRMMSV
       .::. . .  :: .:.:  ..   
NP_001 VPYVFRYFVAELAAMNIKVKLDVV
            980       990      




1174 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 13:40:44 2016 done: Thu Nov  3 13:40:46 2016
 Total Scan time: 14.510 Total Display time:  0.540

Function used was FASTA [36.3.4 Apr, 2011]
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