Result of FASTA (omim) for pF1KB3596
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB3596, 503 aa
  1>>>pF1KB3596 503 - 503 aa - 503 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 13.5967+/-0.000773; mu= -23.6769+/- 0.045
 mean_var=830.4097+/-190.551, 0's: 0 Z-trim(114.2): 105  B-trim: 0 in 0/51
 Lambda= 0.044507
 statistics sampled from 23800 (23893) to 23800 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.622), E-opt: 0.2 (0.28), width:  16
 Scan time:  9.350

The best scores are:                                      opt bits E(85289)
NP_004603 (OMIM: 132800,190181) TGF-beta receptor  ( 503) 3390 234.4   6e-61
NP_001293139 (OMIM: 132800,190181) TGF-beta recept ( 507) 3372 233.2 1.3e-60
XP_011517251 (OMIM: 132800,190181) PREDICTED: TGF- ( 434) 2940 205.4 2.7e-52
XP_016870552 (OMIM: 132800,190181) PREDICTED: TGF- ( 438) 2922 204.2 6.1e-52
XP_011517250 (OMIM: 132800,190181) PREDICTED: TGF- ( 438) 2922 204.2 6.1e-52
NP_004293 (OMIM: 601300) activin receptor type-1B  ( 505) 2314 165.3 3.8e-40
NP_064732 (OMIM: 601300) activin receptor type-1B  ( 453) 2202 158.0 5.2e-38
NP_660302 (OMIM: 608981) activin receptor type-1C  ( 493) 2196 157.7 7.1e-38
XP_011517252 (OMIM: 132800,190181) PREDICTED: TGF- ( 357) 2100 151.4 4.2e-36
NP_001124388 (OMIM: 132800,190181) TGF-beta recept ( 426) 2100 151.5 4.7e-36
NP_001104501 (OMIM: 608981) activin receptor type- ( 443) 2073 149.7 1.6e-35
NP_001104502 (OMIM: 608981) activin receptor type- ( 413) 1773 130.4 9.6e-30
XP_016864048 (OMIM: 112600,603248,609441,616849) P ( 502) 1695 125.5 3.5e-28
XP_016864047 (OMIM: 112600,603248,609441,616849) P ( 502) 1695 125.5 3.5e-28
XP_016864049 (OMIM: 112600,603248,609441,616849) P ( 502) 1695 125.5 3.5e-28
XP_016864050 (OMIM: 112600,603248,609441,616849) P ( 502) 1695 125.5 3.5e-28
NP_001243721 (OMIM: 112600,603248,609441,616849) b ( 502) 1695 125.5 3.5e-28
NP_001243723 (OMIM: 112600,603248,609441,616849) b ( 502) 1695 125.5 3.5e-28
XP_011530503 (OMIM: 112600,603248,609441,616849) P ( 502) 1695 125.5 3.5e-28
NP_001194 (OMIM: 112600,603248,609441,616849) bone ( 502) 1695 125.5 3.5e-28
NP_001243722 (OMIM: 112600,603248,609441,616849) b ( 532) 1695 125.6 3.6e-28
NP_004320 (OMIM: 174900,601299,610069) bone morpho ( 532) 1655 123.0 2.1e-27
XP_011538406 (OMIM: 174900,601299,610069) PREDICTE ( 532) 1655 123.0 2.1e-27
XP_011538405 (OMIM: 174900,601299,610069) PREDICTE ( 532) 1655 123.0 2.1e-27
XP_016875690 (OMIM: 601300) PREDICTED: activin rec ( 381) 1565 117.0 9.6e-26
XP_011510409 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1511 113.7 1.3e-24
XP_011510410 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1511 113.7 1.3e-24
XP_005246997 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1511 113.7 1.3e-24
XP_005246996 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1511 113.7 1.3e-24
XP_006712888 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1511 113.7 1.3e-24
NP_001096 (OMIM: 102576,135100) activin receptor t ( 509) 1511 113.7 1.3e-24
NP_001104537 (OMIM: 102576,135100) activin recepto ( 509) 1511 113.7 1.3e-24
XP_011510408 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1511 113.7 1.3e-24
NP_001070869 (OMIM: 600376,601284) serine/threonin ( 503) 1434 108.8 3.9e-23
XP_005269292 (OMIM: 600376,601284) PREDICTED: seri ( 503) 1434 108.8 3.9e-23
NP_000011 (OMIM: 600376,601284) serine/threonine-p ( 503) 1434 108.8 3.9e-23
XP_016875688 (OMIM: 601300) PREDICTED: activin rec ( 494) 1421 107.9 6.8e-23
XP_016875689 (OMIM: 601300) PREDICTED: activin rec ( 494) 1421 107.9 6.8e-23
NP_064733 (OMIM: 601300) activin receptor type-1B  ( 546) 1421 108.0 7.2e-23
NP_001104503 (OMIM: 608981) activin receptor type- ( 336) 1302 100.1 1.1e-20
XP_011537310 (OMIM: 600376,601284) PREDICTED: seri ( 413) 1264 97.8 6.6e-20
XP_011537269 (OMIM: 601300) PREDICTED: activin rec ( 312)  895 73.9 7.6e-13
XP_016862595 (OMIM: 133239,190182,610168,614331) P ( 532)  808 68.6   5e-11
XP_011532347 (OMIM: 133239,190182,610168,614331) P ( 532)  808 68.6   5e-11
NP_003233 (OMIM: 133239,190182,610168,614331) TGF- ( 567)  808 68.7 5.2e-11
XP_011532345 (OMIM: 133239,190182,610168,614331) P ( 576)  808 68.7 5.3e-11
NP_001020018 (OMIM: 133239,190182,610168,614331) T ( 592)  808 68.7 5.4e-11
NP_001265509 (OMIM: 102581) activin receptor type- ( 405)  800 68.0 6.1e-11
NP_001607 (OMIM: 102581) activin receptor type-2A  ( 513)  800 68.1   7e-11
NP_001265508 (OMIM: 102581) activin receptor type- ( 513)  800 68.1   7e-11


>>NP_004603 (OMIM: 132800,190181) TGF-beta receptor type  (503 aa)
 initn: 3390 init1: 3390 opt: 3390  Z-score: 1215.2  bits: 234.4 E(85289): 6e-61
Smith-Waterman score: 3390; 100.0% identity (100.0% similar) in 503 aa overlap (1-503:1-503)

               10        20        30        40        50        60
pF1KB3 MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 TTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 LGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 IYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 IYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREER
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 SWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVE
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 GMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 ATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 ATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGI
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 HEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 HEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGA
              430       440       450       460       470       480

              490       500   
pF1KB3 ARLTALRIKKTLSQLSQQEGIKM
       :::::::::::::::::::::::
NP_004 ARLTALRIKKTLSQLSQQEGIKM
              490       500   

>>NP_001293139 (OMIM: 132800,190181) TGF-beta receptor t  (507 aa)
 initn: 2626 init1: 2626 opt: 3372  Z-score: 1208.9  bits: 233.2 E(85289): 1.3e-60
Smith-Waterman score: 3372; 99.2% identity (99.2% similar) in 507 aa overlap (1-503:1-507)

               10        20        30        40        50        60
pF1KB3 MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTE
               10        20        30        40        50        60

               70        80        90       100       110          
pF1KB3 TTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTT----VK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::    ::
NP_001 TTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTGPFSVK
               70        80        90       100       110       120

        120       130       140       150       160       170      
pF1KB3 SSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTT
              130       140       150       160       170       180

        180       190       200       210       220       230      
pF1KB3 LKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSS
              190       200       210       220       230       240

        240       250       260       270       280       290      
pF1KB3 REERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 REERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYT
              250       260       270       280       290       300

        300       310       320       330       340       350      
pF1KB3 VTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAV
              310       320       330       340       350       360

        360       370       380       390       400       410      
pF1KB3 RHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCS
              370       380       390       400       410       420

        420       430       440       450       460       470      
pF1KB3 IGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWY
              430       440       450       460       470       480

        480       490       500   
pF1KB3 ANGAARLTALRIKKTLSQLSQQEGIKM
       :::::::::::::::::::::::::::
NP_001 ANGAARLTALRIKKTLSQLSQQEGIKM
              490       500       

>>XP_011517251 (OMIM: 132800,190181) PREDICTED: TGF-beta  (434 aa)
 initn: 2940 init1: 2940 opt: 2940  Z-score: 1059.7  bits: 205.4 E(85289): 2.7e-52
Smith-Waterman score: 2940; 100.0% identity (100.0% similar) in 434 aa overlap (70-503:1-434)

      40        50        60        70        80        90         
pF1KB3 LCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTY
                                     ::::::::::::::::::::::::::::::
XP_011                               MCIAEIDLIPRDRPFVCAPSSKTGSVTTTY
                                             10        20        30

     100       110       120       130       140       150         
pF1KB3 CCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVP
               40        50        60        70        80        90

     160       170       180       190       200       210         
pF1KB3 NEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEV
              100       110       120       130       140       150

     220       230       240       250       260       270         
pF1KB3 WRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLV
              160       170       180       190       200       210

     280       290       300       310       320       330         
pF1KB3 SDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNI
              220       230       240       250       260       270

     340       350       360       370       380       390         
pF1KB3 LVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRA
              280       290       300       310       320       330

     400       410       420       430       440       450         
pF1KB3 DIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQ
              340       350       360       370       380       390

     460       470       480       490       500   
pF1KB3 SCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
       ::::::::::::::::::::::::::::::::::::::::::::
XP_011 SCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
              400       410       420       430    

>>XP_016870552 (OMIM: 132800,190181) PREDICTED: TGF-beta  (438 aa)
 initn: 2626 init1: 2626 opt: 2922  Z-score: 1053.4  bits: 204.2 E(85289): 6.1e-52
Smith-Waterman score: 2922; 99.1% identity (99.1% similar) in 438 aa overlap (70-503:1-438)

      40        50        60        70        80        90         
pF1KB3 LCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTY
                                     ::::::::::::::::::::::::::::::
XP_016                               MCIAEIDLIPRDRPFVCAPSSKTGSVTTTY
                                             10        20        30

     100       110           120       130       140       150     
pF1KB3 CCNQDHCNKIELPTT----VKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIH
       :::::::::::::::    :::::::::::::::::::::::::::::::::::::::::
XP_016 CCNQDHCNKIELPTTGPFSVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIH
               40        50        60        70        80        90

         160       170       180       190       200       210     
pF1KB3 HRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGR
              100       110       120       130       140       150

         220       230       240       250       260       270     
pF1KB3 FGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQ
              160       170       180       190       200       210

         280       290       300       310       320       330     
pF1KB3 LWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLK
              220       230       240       250       260       270

         340       350       360       370       380       390     
pF1KB3 SKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFES
              280       290       300       310       320       330

         400       410       420       430       440       450     
pF1KB3 FKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIP
              340       350       360       370       380       390

         460       470       480       490       500   
pF1KB3 NRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
       ::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
              400       410       420       430        

>>XP_011517250 (OMIM: 132800,190181) PREDICTED: TGF-beta  (438 aa)
 initn: 2626 init1: 2626 opt: 2922  Z-score: 1053.4  bits: 204.2 E(85289): 6.1e-52
Smith-Waterman score: 2922; 99.1% identity (99.1% similar) in 438 aa overlap (70-503:1-438)

      40        50        60        70        80        90         
pF1KB3 LCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTY
                                     ::::::::::::::::::::::::::::::
XP_011                               MCIAEIDLIPRDRPFVCAPSSKTGSVTTTY
                                             10        20        30

     100       110           120       130       140       150     
pF1KB3 CCNQDHCNKIELPTT----VKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIH
       :::::::::::::::    :::::::::::::::::::::::::::::::::::::::::
XP_011 CCNQDHCNKIELPTTGPFSVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIH
               40        50        60        70        80        90

         160       170       180       190       200       210     
pF1KB3 HRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGR
              100       110       120       130       140       150

         220       230       240       250       260       270     
pF1KB3 FGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQ
              160       170       180       190       200       210

         280       290       300       310       320       330     
pF1KB3 LWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLK
              220       230       240       250       260       270

         340       350       360       370       380       390     
pF1KB3 SKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFES
              280       290       300       310       320       330

         400       410       420       430       440       450     
pF1KB3 FKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIP
              340       350       360       370       380       390

         460       470       480       490       500   
pF1KB3 NRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
       ::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
              400       410       420       430        

>>NP_004293 (OMIM: 601300) activin receptor type-1B isof  (505 aa)
 initn: 2285 init1: 1991 opt: 2314  Z-score: 841.8  bits: 165.3 E(85289): 3.8e-40
Smith-Waterman score: 2314; 69.5% identity (84.1% similar) in 511 aa overlap (2-503:3-505)

                10        20        30        40        50         
pF1KB3  MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVT
         :.: :.    :..:.::......     :. :: : :  : . :.:: ::: :.::. 
NP_004 MAESAGASSFFPLVVLLLAGSGGSGPR---GVQALLCACTSCLQANYTCETDGACMVSIF
               10        20           30        40        50       

      60        70        80        90       100       110         
pF1KB3 ETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIEL--PTT-VK
       .      :   :: ...:.:  .:: :  :    .. .:.::  :.::.:.:  :.  .:
NP_004 NLDGMEHHVRTCIPKVELVPAGKPFYCLSSE---DLRNTHCCYTDYCNRIDLRVPSGHLK
        60        70        80           90       100       110    

          120        130         140       150        160       170
pF1KB3 SS--PGL-GPVELAAVIAGPVC--FVCISLMLMVYICHNRTVIHHRVP-NEEDPSLDRPF
           :.. :::::...:::::   :. : ....:   :.: : :.:   . :::: .   
NP_004 EPEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQR-VYHNRQRLDMEDPSCEM-C
          120       130       140       150        160       170   

              180       190       200       210       220       230
pF1KB3 ISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVA
       .:.  ::.::.::..::::::::::.::::.:::::::: ::::::::::::.::: .::
NP_004 LSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVA
            180       190       200       210       220       230  

              240       250       260       270       280       290
pF1KB3 VKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFD
            240       250       260       270       280       290  

              300       310       320       330       340       350
pF1KB3 YLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIA
       ::::::::.:::::::::.::::::::::::::::::.::::::::::::::::: : ::
NP_004 YLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIA
            300       310       320       330       340       350  

              360       370       380       390       400       410
pF1KB3 DLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWE
       :::::::::..:::::::::.::::::::::::::..::::::.::: :::::.:::.::
NP_004 DLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWE
            360       370       380       390       400       410  

              420       430       440       450       460       470
pF1KB3 IARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKI
       :::::. ::.::.::::::::::::::.::::::::.::::::::: ::: ::::::.:.
NP_004 IARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKM
            420       430       440       450       460       470  

              480       490       500   
pF1KB3 MRECWYANGAARLTALRIKKTLSQLSQQEGIKM
       :::::::::::::::::::::::::: :: .:.
NP_004 MRECWYANGAARLTALRIKKTLSQLSVQEDVKI
            480       490       500     

>>NP_064732 (OMIM: 601300) activin receptor type-1B isof  (453 aa)
 initn: 2181 init1: 1991 opt: 2202  Z-score: 803.4  bits: 158.0 E(85289): 5.2e-38
Smith-Waterman score: 2202; 74.7% identity (87.7% similar) in 446 aa overlap (67-503:13-453)

         40        50        60        70        80        90      
pF1KB3 FCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVT
                                     :   :: ...:.:  .:: :  :    .. 
NP_064                   MVSIFNLDGMEHHVRTCIPKVELVPAGKPFYCLSSE---DLR
                                 10        20        30            

        100       110            120        130         140        
pF1KB3 TTYCCNQDHCNKIEL--PTT-VKSS--PGL-GPVELAAVIAGPVC--FVCISLMLMVYIC
       .:.::  :.::.:.:  :.  .:    :.. :::::...:::::   :. : ....:   
NP_064 NTHCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINY
      40        50        60        70        80        90         

      150        160       170       180       190       200       
pF1KB3 HNRTVIHHRVP-NEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVL
       :.: : :.:   . :::: .   .:.  ::.::.::..::::::::::.::::.::::::
NP_064 HQR-VYHNRQRLDMEDPSCEM-CLSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVL
     100        110        120       130       140       150       

       210       220       230       240       250       260       
pF1KB3 QESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADN
       :: ::::::::::::.::: .:::::::::::::::::::::::::::::::::::::::
NP_064 QEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADN
       160       170       180       190       200       210       

       270       280       290       300       310       320       
pF1KB3 KDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKP
       :::::::::::::::::::::::::::::::.:::::::::.::::::::::::::::::
NP_064 KDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKP
       220       230       240       250       260       270       

       330       340       350       360       370       380       
pF1KB3 AIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDS
       .::::::::::::::::: : :::::::::::..:::::::::.::::::::::::::..
NP_064 GIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDET
       280       290       300       310       320       330       

       390       400       410       420       430       440       
pF1KB3 INMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCE
       ::::::.::: :::::.:::.:::::::. ::.::.::::::::::::::.::::::::.
NP_064 INMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCD
       340       350       360       370       380       390       

       450       460       470       480       490       500   
pF1KB3 QKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
       ::::::::: ::: ::::::.:.:::::::::::::::::::::::::: :: .:.
NP_064 QKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQEDVKI
       400       410       420       430       440       450   

>>NP_660302 (OMIM: 608981) activin receptor type-1C isof  (493 aa)
 initn: 2141 init1: 1892 opt: 2196  Z-score: 800.9  bits: 157.7 E(85289): 7.1e-38
Smith-Waterman score: 2202; 67.7% identity (81.7% similar) in 504 aa overlap (3-502:4-492)

                10        20        30        40        50         
pF1KB3  MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVT
          :  .: :  ::::      :::: : ::   :.: : :: ..:::: :.: :..:: 
NP_660 MTRALCSALRQALLLL------AAAAELSPG---LKCVCLLCDSSNFTCQTEGACWASVM
               10              20           30        40        50 

      60        70        80        90       100         110       
pF1KB3 ETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKI--ELPTTVKS
        :. :    . :..  .:   .    :  :.   .:: : ::  : ::.:  .:::.  .
NP_660 LTNGKEQVIKSCVSLPEL---NAQVFCHSSN---NVTKTECCFTDFCNNITLHLPTASPN
              60           70           80        90       100     

       120       130       140       150         160       170     
pF1KB3 SPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRV--PNEEDPSLDRPFISEGT
       .: :::.::: .:. :::.. :. :: :. :..:   ...   :: :.:  .  ... : 
NP_660 APKLGPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGK
         110       120       130       140       150       160     

         180       190       200       210       220       230     
pF1KB3 TLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFS
       ::::::::.:.::::::::::::::::::::::: .:::::::::.:.: ::.:::::::
NP_660 TLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFS
         170       180       190       200       210       220     

         240       250       260       270       280       290     
pF1KB3 SREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRY
       ::.::::::::::::::::::::::::::::::::::::::::::.:::.:::.::::: 
NP_660 SRDERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRN
         230       240       250       260       270       280     

         300       310       320       330       340       350     
pF1KB3 TVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLA
        ::: :::::::: ::::::::::::::::::::::::.:::::::::  :: :::::::
NP_660 IVTVAGMIKLALSIASGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLA
         290       300       310       320       330       340     

         360       370       380       390       400       410     
pF1KB3 VRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRC
       :.:::  .::::  : .::::::::::.:::..:.. ::::::::::..:::.:::::::
NP_660 VKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRC
         350       360       370       380       390       400     

         420       430       440       450       460       470     
pF1KB3 SIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECW
       :.::: :.:::::::.::::::.::::::::.::.::.:::.::::::::::..::::::
NP_660 SVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECW
         410       420       430       440       450       460     

         480       490       500   
pF1KB3 YANGAARLTALRIKKTLSQLSQQEGIKM
       ::::::::::::::::.:::  .:  : 
NP_660 YANGAARLTALRIKKTISQLCVKEDCKA
         470       480       490   

>>XP_011517252 (OMIM: 132800,190181) PREDICTED: TGF-beta  (357 aa)
 initn: 2100 init1: 2100 opt: 2100  Z-score: 769.1  bits: 151.4 E(85289): 4.2e-36
Smith-Waterman score: 2258; 82.3% identity (82.3% similar) in 434 aa overlap (70-503:1-357)

      40        50        60        70        80        90         
pF1KB3 LCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTY
                                     ::::::::::::::::::::::::::::::
XP_011                               MCIAEIDLIPRDRPFVCAPSSKTGSVTTTY
                                             10        20        30

     100       110       120       130       140       150         
pF1KB3 CCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVP
       :::::::::::::::                                             
XP_011 CCNQDHCNKIELPTT---------------------------------------------
               40                                                  

     160       170       180       190       200       210         
pF1KB3 NEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEV
                                       ::::::::::::::::::::::::::::
XP_011 --------------------------------GLPLLVQRTIARTIVLQESIGKGRFGEV
                                          50        60        70   

     220       230       240       250       260       270         
pF1KB3 WRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLV
            80        90       100       110       120       130   

     280       290       300       310       320       330         
pF1KB3 SDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNI
           140       150       160       170       180       190   

     340       350       360       370       380       390         
pF1KB3 LVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRA
           200       210       220       230       240       250   

     400       410       420       430       440       450         
pF1KB3 DIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQ
           260       270       280       290       300       310   

     460       470       480       490       500   
pF1KB3 SCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
       ::::::::::::::::::::::::::::::::::::::::::::
XP_011 SCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
           320       330       340       350       

>>NP_001124388 (OMIM: 132800,190181) TGF-beta receptor t  (426 aa)
 initn: 2100 init1: 2100 opt: 2100  Z-score: 768.3  bits: 151.5 E(85289): 4.7e-36
Smith-Waterman score: 2708; 84.7% identity (84.7% similar) in 503 aa overlap (1-503:1-426)

               10        20        30        40        50        60
pF1KB3 MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 TTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::      
NP_001 TTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTT------
               70        80        90       100       110          

              130       140       150       160       170       180
pF1KB3 LGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDL
                                                                   
NP_001 ------------------------------------------------------------
                                                                   

              190       200       210       220       230       240
pF1KB3 IYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREER
                  :::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 -----------GLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREER
                     120       130       140       150       160   

              250       260       270       280       290       300
pF1KB3 SWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVE
           170       180       190       200       210       220   

              310       320       330       340       350       360
pF1KB3 GMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS
           230       240       250       260       270       280   

              370       380       390       400       410       420
pF1KB3 ATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGI
           290       300       310       320       330       340   

              430       440       450       460       470       480
pF1KB3 HEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGA
           350       360       370       380       390       400   

              490       500   
pF1KB3 ARLTALRIKKTLSQLSQQEGIKM
       :::::::::::::::::::::::
NP_001 ARLTALRIKKTLSQLSQQEGIKM
           410       420      




503 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 13:31:04 2016 done: Thu Nov  3 13:31:06 2016
 Total Scan time:  9.350 Total Display time:  0.110

Function used was FASTA [36.3.4 Apr, 2011]
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