Result of FASTA (omim) for pF1KB3349
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB3349, 1527 aa
  1>>>pF1KB3349 1527 - 1527 aa - 1527 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.6950+/-0.00051; mu= 21.9193+/- 0.031
 mean_var=88.4816+/-18.014, 0's: 0 Z-trim(108.9): 232  B-trim: 196 in 2/49
 Lambda= 0.136348
 statistics sampled from 16714 (16991) to 16714 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.531), E-opt: 0.2 (0.199), width:  16
 Scan time: 15.950

The best scores are:                                      opt bits E(85289)
NP_003777 (OMIM: 604323) canalicular multispecific (1527) 10037 1986.1       0
XP_011523726 (OMIM: 604323) PREDICTED: canalicular (1302) 8462 1676.3       0
XP_005257820 (OMIM: 604323) PREDICTED: canalicular (1463) 7756 1537.4       0
XP_011523727 (OMIM: 604323) PREDICTED: canalicular (1285) 7008 1390.3       0
XP_016880754 (OMIM: 604323) PREDICTED: canalicular (1285) 7008 1390.3       0
XP_011523724 (OMIM: 604323) PREDICTED: canalicular (1498) 7008 1390.3       0
XP_011523725 (OMIM: 604323) PREDICTED: canalicular (1562) 7008 1390.3       0
XP_016880755 (OMIM: 604323) PREDICTED: canalicular (1271) 5091 1013.2       0
XP_006717693 (OMIM: 237500,601107) PREDICTED: cana (1313) 4132 824.5       0
NP_000383 (OMIM: 237500,601107) canalicular multis (1545) 4132 824.6       0
NP_001137542 (OMIM: 604323) canalicular multispeci ( 572) 3682 735.8 2.4e-211
NP_004987 (OMIM: 158343) multidrug resistance-asso (1531) 3324 665.6 8.3e-190
XP_016878726 (OMIM: 158343) PREDICTED: multidrug r (1549) 3306 662.1 9.8e-189
XP_011520799 (OMIM: 158343) PREDICTED: multidrug r (1523) 3303 661.5 1.5e-188
XP_016878728 (OMIM: 158343) PREDICTED: multidrug r (1503) 2748 552.3 1.1e-155
XP_016878727 (OMIM: 158343) PREDICTED: multidrug r (1507) 2628 528.7 1.3e-148
XP_016878730 (OMIM: 158343) PREDICTED: multidrug r (1461) 2605 524.2  3e-147
XP_016878731 (OMIM: 158343) PREDICTED: multidrug r (1434) 2475 498.6 1.5e-139
XP_016878729 (OMIM: 158343) PREDICTED: multidrug r (1490) 2475 498.6 1.5e-139
XP_011520800 (OMIM: 158343) PREDICTED: multidrug r (1500) 2475 498.6 1.5e-139
XP_016878732 (OMIM: 158343) PREDICTED: multidrug r ( 931) 2410 485.7 7.5e-136
XP_011520784 (OMIM: 177850,264800,603234,614473) P ( 887) 2354 474.7 1.5e-132
XP_016878703 (OMIM: 177850,264800,603234,614473) P (1166) 2353 474.6 2.1e-132
XP_016871164 (OMIM: 237500,601107) PREDICTED: cana ( 892) 2034 411.7 1.3e-113
XP_006717694 (OMIM: 237500,601107) PREDICTED: cana ( 895) 2033 411.5 1.5e-113
XP_011537593 (OMIM: 237500,601107) PREDICTED: cana ( 916) 2030 410.9 2.3e-113
XP_005253346 (OMIM: 239850,601439,608569,614050) P (1536) 1869 379.4 1.2e-103
XP_006719088 (OMIM: 239850,601439,608569,614050) P (1536) 1866 378.8 1.8e-103
XP_016866941 (OMIM: 612509) PREDICTED: multidrug r (1339) 1777 361.3   3e-98
NP_258261 (OMIM: 612509) multidrug resistance-asso (1464) 1777 361.3 3.2e-98
XP_016866935 (OMIM: 612509) PREDICTED: multidrug r (1507) 1777 361.3 3.3e-98
XP_016866936 (OMIM: 612509) PREDICTED: multidrug r (1507) 1777 361.3 3.3e-98
XP_016866934 (OMIM: 612509) PREDICTED: multidrug r (1558) 1777 361.3 3.4e-98
XP_011520783 (OMIM: 177850,264800,603234,614473) P (1389) 1734 352.9 1.1e-95
XP_011520782 (OMIM: 177850,264800,603234,614473) P (1389) 1734 352.9 1.1e-95
XP_016878702 (OMIM: 177850,264800,603234,614473) P (1389) 1734 352.9 1.1e-95
XP_016878701 (OMIM: 177850,264800,603234,614473) P (1447) 1734 352.9 1.1e-95
XP_011520781 (OMIM: 177850,264800,603234,614473) P (1492) 1734 352.9 1.2e-95
NP_001162 (OMIM: 177850,264800,603234,614473) mult (1503) 1734 352.9 1.2e-95
XP_016866938 (OMIM: 612509) PREDICTED: multidrug r (1501) 1547 316.1 1.4e-84
XP_016866937 (OMIM: 612509) PREDICTED: multidrug r (1501) 1547 316.1 1.4e-84
XP_016879288 (OMIM: 117800,607040) PREDICTED: ATP- (1382) 1492 305.2 2.3e-81
XP_016879285 (OMIM: 117800,607040) PREDICTED: ATP- (1382) 1492 305.2 2.3e-81
XP_016879284 (OMIM: 117800,607040) PREDICTED: ATP- (1382) 1492 305.2 2.3e-81
XP_016879287 (OMIM: 117800,607040) PREDICTED: ATP- (1382) 1492 305.2 2.3e-81
XP_016879286 (OMIM: 117800,607040) PREDICTED: ATP- (1382) 1492 305.2 2.3e-81
XP_016879289 (OMIM: 117800,607040) PREDICTED: ATP- (1382) 1492 305.2 2.3e-81
NP_115972 (OMIM: 117800,607040) ATP-binding casset (1382) 1492 305.2 2.3e-81
NP_149163 (OMIM: 117800,607040) ATP-binding casset (1382) 1492 305.2 2.3e-81
XP_016866943 (OMIM: 612509) PREDICTED: multidrug r (1063) 1471 301.0 3.3e-80


>>NP_003777 (OMIM: 604323) canalicular multispecific org  (1527 aa)
 initn: 10037 init1: 10037 opt: 10037  Z-score: 10665.2  bits: 1986.1 E(85289):    0
Smith-Waterman score: 10037; 99.9% identity (99.9% similar) in 1527 aa overlap (1-1527:1-1527)

               10        20        30        40        50        60
pF1KB3 MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHC
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 RGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLAT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLAT
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 LLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFAL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 VLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 VLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 WSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 WSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFL
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 KALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 KALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCS
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 MMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRF
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 MDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQ
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB3 MKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWM
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB3 CSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 CSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLK
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB3 RIQQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RIQQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVV
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB3 GPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 GPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRY
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB3 QQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 QQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSA
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB3 VDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 VDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQ
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB3 RNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQ
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KB3 KQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 KQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFW
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KB3 DYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 DYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGI
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KB3 LQGFLVMLAAMAMAAGGIQAARVLHQALPHNKIRSPQSFFDTTPSGRILNCFSKDIYVVD
       :::::::::::::::::::::::::::: :::::::::::::::::::::::::::::::
NP_003 LQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVD
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KB3 EVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 EVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLE
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KB3 SVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVE
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KB3 FVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 FVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERV
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KB3 KEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 KEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVG
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KB3 IVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 IVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTL
             1330      1340      1350      1360      1370      1380

             1390      1400      1410      1420      1430      1440
pF1KB3 RMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARAL
             1390      1400      1410      1420      1430      1440

             1450      1460      1470      1480      1490      1500
pF1KB3 LRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGV
             1450      1460      1470      1480      1490      1500

             1510      1520       
pF1KB3 VAEFDSPANLIAARGIFYGMARDAGLA
       :::::::::::::::::::::::::::
NP_003 VAEFDSPANLIAARGIFYGMARDAGLA
             1510      1520       

>>XP_011523726 (OMIM: 604323) PREDICTED: canalicular mul  (1302 aa)
 initn: 8462 init1: 8462 opt: 8462  Z-score: 8991.8  bits: 1676.3 E(85289):    0
Smith-Waterman score: 8462; 99.9% identity (99.9% similar) in 1302 aa overlap (226-1527:1-1302)

         200       210       220       230       240       250     
pF1KB3 FFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQ
                                     ::::::::::::::::::::::::::::::
XP_011                               MAIYGYRHPLEEKDLWSLKEEDRSQMVVQQ
                                             10        20        30

         260       270       280       290       300       310     
pF1KB3 LLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISA
               40        50        60        70        80        90

         320       330       340       350       360       370     
pF1KB3 CFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQHYYHYIF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQHYYHYIF
              100       110       120       130       140       150

         380       390       400       410       420       430     
pF1KB3 VTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPL
              160       170       180       190       200       210

         440       450       460       470       480       490     
pF1KB3 QIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEIL
              220       230       240       250       260       270

         500       510       520       530       540       550     
pF1KB3 NGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYV
              280       290       300       310       320       330

         560       570       580       590       600       610     
pF1KB3 YVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQS
              340       350       360       370       380       390

         620       630       640       650       660       670     
pF1KB3 VERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALL
              400       410       420       430       440       450

         680       690       700       710       720       730     
pF1KB3 GEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEM
              460       470       480       490       500       510

         740       750       760       770       780       790     
pF1KB3 LPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIG
              520       530       540       550       560       570

         800       810       820       830       840       850     
pF1KB3 PEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPD
              580       590       600       610       620       630

         860       870       880       890       900       910     
pF1KB3 EDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGE
              640       650       660       670       680       690

         920       930       940       950       960       970     
pF1KB3 GQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTLAIC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTLAIC
              700       710       720       730       740       750

         980       990      1000      1010      1020      1030     
pF1KB3 LLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMAMAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMAMAA
              760       770       780       790       800       810

        1040      1050      1060      1070      1080      1090     
pF1KB3 GGIQAARVLHQALPHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFF
       ::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFF
              820       830       840       850       860       870

        1100      1110      1120      1130      1140      1150     
pF1KB3 NAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFSETV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFSETV
              880       890       900       910       920       930

        1160      1170      1180      1190      1200      1210     
pF1KB3 TGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAALFAV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAALFAV
              940       950       960       970       980       990

        1220      1230      1240      1250      1260      1270     
pF1KB3 IGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVE
             1000      1010      1020      1030      1040      1050

        1280      1290      1300      1310      1320      1330     
pF1KB3 GSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLC
             1060      1070      1080      1090      1100      1110

        1340      1350      1360      1370      1380      1390     
pF1KB3 LFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDI
             1120      1130      1140      1150      1160      1170

        1400      1410      1420      1430      1440      1450     
pF1KB3 WWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAA
             1180      1190      1200      1210      1220      1230

        1460      1470      1480      1490      1500      1510     
pF1KB3 IDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARG
             1240      1250      1260      1270      1280      1290

        1520       
pF1KB3 IFYGMARDAGLA
       ::::::::::::
XP_011 IFYGMARDAGLA
             1300  

>>XP_005257820 (OMIM: 604323) PREDICTED: canalicular mul  (1463 aa)
 initn: 7756 init1: 7756 opt: 7756  Z-score: 8240.5  bits: 1537.4 E(85289):    0
Smith-Waterman score: 9487; 95.7% identity (95.7% similar) in 1527 aa overlap (1-1527:1-1463)

               10        20        30        40        50        60
pF1KB3 MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHC
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 RGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLAT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLAT
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 LLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFAL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 VLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 WSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFL
       :::::::::::::::::::::::::::::                               
XP_005 WSLKEEDRSQMVVQQLLEAWRKQEKQTAR-------------------------------
              250       260                                        

              310       320       330       340       350       360
pF1KB3 KALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCS
                                        :::::::::::::::::::::::::::
XP_005 ---------------------------------ILIRFISNPMAPSWWGFLVAGLMFLCS
                                      270       280       290      

              370       380       390       400       410       420
pF1KB3 MMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRF
        300       310       320       330       340       350      

              430       440       450       460       470       480
pF1KB3 MDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQ
        360       370       380       390       400       410      

              490       500       510       520       530       540
pF1KB3 MKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWM
        420       430       440       450       460       470      

              550       560       570       580       590       600
pF1KB3 CSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLK
        480       490       500       510       520       530      

              610       620       630       640       650       660
pF1KB3 RIQQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RIQQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVV
        540       550       560       570       580       590      

              670       680       690       700       710       720
pF1KB3 GPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRY
        600       610       620       630       640       650      

              730       740       750       760       770       780
pF1KB3 QQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSA
        660       670       680       690       700       710      

              790       800       810       820       830       840
pF1KB3 VDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQ
        720       730       740       750       760       770      

              850       860       870       880       890       900
pF1KB3 RNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQ
        780       790       800       810       820       830      

              910       920       930       940       950       960
pF1KB3 KQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFW
        840       850       860       870       880       890      

              970       980       990      1000      1010      1020
pF1KB3 DYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGI
        900       910       920       930       940       950      

             1030      1040      1050      1060      1070      1080
pF1KB3 LQGFLVMLAAMAMAAGGIQAARVLHQALPHNKIRSPQSFFDTTPSGRILNCFSKDIYVVD
       :::::::::::::::::::::::::::: :::::::::::::::::::::::::::::::
XP_005 LQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVD
        960       970       980       990      1000      1010      

             1090      1100      1110      1120      1130      1140
pF1KB3 EVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLE
       1020      1030      1040      1050      1060      1070      

             1150      1160      1170      1180      1190      1200
pF1KB3 SVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVE
       1080      1090      1100      1110      1120      1130      

             1210      1220      1230      1240      1250      1260
pF1KB3 FVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERV
       1140      1150      1160      1170      1180      1190      

             1270      1280      1290      1300      1310      1320
pF1KB3 KEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVG
       1200      1210      1220      1230      1240      1250      

             1330      1340      1350      1360      1370      1380
pF1KB3 IVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTL
       1260      1270      1280      1290      1300      1310      

             1390      1400      1410      1420      1430      1440
pF1KB3 RMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARAL
       1320      1330      1340      1350      1360      1370      

             1450      1460      1470      1480      1490      1500
pF1KB3 LRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGV
       1380      1390      1400      1410      1420      1430      

             1510      1520       
pF1KB3 VAEFDSPANLIAARGIFYGMARDAGLA
       :::::::::::::::::::::::::::
XP_005 VAEFDSPANLIAARGIFYGMARDAGLA
       1440      1450      1460   

>>XP_011523727 (OMIM: 604323) PREDICTED: canalicular mul  (1285 aa)
 initn: 7008 init1: 7008 opt: 7008  Z-score: 7446.1  bits: 1390.3 E(85289):    0
Smith-Waterman score: 7008; 99.9% identity (99.9% similar) in 1082 aa overlap (446-1527:204-1285)

         420       430       440       450       460       470     
pF1KB3 DAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRA
                                     ::::::::::::::::::::::::::::::
XP_011 STPADHPGDLLPLADFGNLSLCVIYPPVPPQNLGPSVLAGVAFMVLLIPLNGAVAVKMRA
           180       190       200       210       220       230   

         480       490       500       510       520       530     
pF1KB3 FQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTT
           240       250       260       270       280       290   

         540       550       560       570       580       590     
pF1KB3 TFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQA
           300       310       320       330       340       350   

         600       610       620       630       640       650     
pF1KB3 SVSLKRIQQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SVSLKRIQQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGA
           360       370       380       390       400       410   

         660       670       680       690       700       710     
pF1KB3 LVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKAL
           420       430       440       450       460       470   

         720       730       740       750       760       770     
pF1KB3 NPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLD
           480       490       500       510       520       530   

         780       790       800       810       820       830     
pF1KB3 DPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPY
           540       550       560       570       580       590   

         840       850       860       870       880       890     
pF1KB3 PALLQRNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PALLQRNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPV
           600       610       620       630       640       650   

         900       910       920       930       940       950     
pF1KB3 TYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVE
           660       670       680       690       700       710   

         960       970       980       990      1000      1010     
pF1KB3 LSVFWDYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSVFWDYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVY
           720       730       740       750       760       770   

        1020      1030      1040      1050      1060      1070     
pF1KB3 AALGILQGFLVMLAAMAMAAGGIQAARVLHQALPHNKIRSPQSFFDTTPSGRILNCFSKD
       ::::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::
XP_011 AALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKD
           780       790       800       810       820       830   

        1080      1090      1100      1110      1120      1130     
pF1KB3 IYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQ
           840       850       860       870       880       890   

        1140      1150      1160      1170      1180      1190     
pF1KB3 LKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWL
           900       910       920       930       940       950   

        1200      1210      1220      1230      1240      1250     
pF1KB3 SIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIV
           960       970       980       990      1000      1010   

        1260      1270      1280      1290      1300      1310     
pF1KB3 AVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHG
          1020      1030      1040      1050      1060      1070   

        1320      1330      1340      1350      1360      1370     
pF1KB3 GEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPIL
          1080      1090      1100      1110      1120      1130   

        1380      1390      1400      1410      1420      1430     
pF1KB3 FSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVC
          1140      1150      1160      1170      1180      1190   

        1440      1450      1460      1470      1480      1490     
pF1KB3 LARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLV
          1200      1210      1220      1230      1240      1250   

        1500      1510      1520       
pF1KB3 LDKGVVAEFDSPANLIAARGIFYGMARDAGLA
       ::::::::::::::::::::::::::::::::
XP_011 LDKGVVAEFDSPANLIAARGIFYGMARDAGLA
          1260      1270      1280     

>>XP_016880754 (OMIM: 604323) PREDICTED: canalicular mul  (1285 aa)
 initn: 7008 init1: 7008 opt: 7008  Z-score: 7446.1  bits: 1390.3 E(85289):    0
Smith-Waterman score: 7008; 99.9% identity (99.9% similar) in 1082 aa overlap (446-1527:204-1285)

         420       430       440       450       460       470     
pF1KB3 DAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRA
                                     ::::::::::::::::::::::::::::::
XP_016 STPADHPGDLLPLADFGNLSLCVIYPPVPPQNLGPSVLAGVAFMVLLIPLNGAVAVKMRA
           180       190       200       210       220       230   

         480       490       500       510       520       530     
pF1KB3 FQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTT
           240       250       260       270       280       290   

         540       550       560       570       580       590     
pF1KB3 TFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQA
           300       310       320       330       340       350   

         600       610       620       630       640       650     
pF1KB3 SVSLKRIQQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVSLKRIQQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGA
           360       370       380       390       400       410   

         660       670       680       690       700       710     
pF1KB3 LVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKAL
           420       430       440       450       460       470   

         720       730       740       750       760       770     
pF1KB3 NPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLD
           480       490       500       510       520       530   

         780       790       800       810       820       830     
pF1KB3 DPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPY
           540       550       560       570       580       590   

         840       850       860       870       880       890     
pF1KB3 PALLQRNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PALLQRNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPV
           600       610       620       630       640       650   

         900       910       920       930       940       950     
pF1KB3 TYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVE
           660       670       680       690       700       710   

         960       970       980       990      1000      1010     
pF1KB3 LSVFWDYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSVFWDYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVY
           720       730       740       750       760       770   

        1020      1030      1040      1050      1060      1070     
pF1KB3 AALGILQGFLVMLAAMAMAAGGIQAARVLHQALPHNKIRSPQSFFDTTPSGRILNCFSKD
       ::::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::
XP_016 AALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKD
           780       790       800       810       820       830   

        1080      1090      1100      1110      1120      1130     
pF1KB3 IYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQ
           840       850       860       870       880       890   

        1140      1150      1160      1170      1180      1190     
pF1KB3 LKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWL
           900       910       920       930       940       950   

        1200      1210      1220      1230      1240      1250     
pF1KB3 SIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIV
           960       970       980       990      1000      1010   

        1260      1270      1280      1290      1300      1310     
pF1KB3 AVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHG
          1020      1030      1040      1050      1060      1070   

        1320      1330      1340      1350      1360      1370     
pF1KB3 GEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPIL
          1080      1090      1100      1110      1120      1130   

        1380      1390      1400      1410      1420      1430     
pF1KB3 FSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVC
          1140      1150      1160      1170      1180      1190   

        1440      1450      1460      1470      1480      1490     
pF1KB3 LARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLV
          1200      1210      1220      1230      1240      1250   

        1500      1510      1520       
pF1KB3 LDKGVVAEFDSPANLIAARGIFYGMARDAGLA
       ::::::::::::::::::::::::::::::::
XP_016 LDKGVVAEFDSPANLIAARGIFYGMARDAGLA
          1260      1270      1280     

>>XP_011523724 (OMIM: 604323) PREDICTED: canalicular mul  (1498 aa)
 initn: 8572 init1: 7008 opt: 7008  Z-score: 7445.2  bits: 1390.3 E(85289):    0
Smith-Waterman score: 8503; 87.2% identity (90.5% similar) in 1540 aa overlap (1-1527:1-1498)

               10        20        30        40        50        60
pF1KB3 MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHC
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 RGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLAT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLAT
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 LLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFAL
              130       140       150       160       170       180

              190       200       210       220               230  
pF1KB3 VLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKM--------AIYGYR
       :::::::::::::::::::::::::::::::::::::::::::::.         . :. 
XP_011 VLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKLLNPDPLRGCLPGFT
              190       200       210       220       230       240

            240       250       260       270       280       290  
pF1KB3 HPLEEKDLWSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARP
        : ..  ::          .:        : . :     :.:: : . .:. .   :..:
XP_011 SP-QDGHLWLPASPGGEGPLVP-------KGRGQIPDGGAAAAGGMEEAGKAD---GTHP
               250       260              270       280            

                 300       310       320       330       340       
pF1KB3 -----RPRKPSFLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSW
            .:. :     :..  :.   . .    . :: ...              :.    
XP_011 DQVYLQPHGP----LLVGLPGGWADVPVLHDAVADLTTLL--------------PLHLCD
     290           300       310       320                     330 

       350       360       370       380       390       400       
pF1KB3 WGFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVG
       ::  :.     : ....   ..  .     : . .  . :     ::     . ....: 
XP_011 WGE-VSYWDHGCHLQEGSGYHQLSQTCVHCGGNCQPHVSGC---PALHGPCPLPQSAVV-
              340       350       360       370          380       

       410       420       430       440       450       460       
pF1KB3 EIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNG
             :. :..  :: :. ..  .  : .:       ::::::::::::::::::::::
XP_011 ------STPADHPGDLLPLADF-GNLSLCVIYPPVPP-QNLGPSVLAGVAFMVLLIPLNG
              390       400        410        420       430        

       470       480       490       500       510       520       
pF1KB3 AVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRT
      440       450       460       470       480       490        

       530       540       550       560       570       580       
pF1KB3 AAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQ
      500       510       520       530       540       550        

       590       600       610       620       630       640       
pF1KB3 LISNLTQASVSLKRIQQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LISNLTQASVSLKRIQQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSL
      560       570       580       590       600       610        

       650       660       670       680       690       700       
pF1KB3 DIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQE
      620       630       640       650       660       670        

       710       720       730       740       750       760       
pF1KB3 NVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYS
      680       690       700       710       720       730        

       770       780       790       800       810       820       
pF1KB3 DADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADG
      740       750       760       770       780       790        

       830       840       850       860       870       880       
pF1KB3 QVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHT
      800       810       820       830       840       850        

       890       900       910       920       930       940       
pF1KB3 DLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEE
      860       870       880       890       900       910        

       950       960       970       980       990      1000       
pF1KB3 KAAIGTVELSVFWDYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KAAIGTVELSVFWDYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNN
      920       930       940       950       960       970        

      1010      1020      1030      1040      1050      1060       
pF1KB3 TSLRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALPHNKIRSPQSFFDTTPSGR
       ::::::::::::::::::::::::::::::::::::::::: ::::::::::::::::::
XP_011 TSLRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGR
      980       990      1000      1010      1020      1030        

      1070      1080      1090      1100      1110      1120       
pF1KB3 ILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQR
     1040      1050      1060      1070      1080      1090        

      1130      1140      1150      1160      1170      1180       
pF1KB3 FYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYP
     1100      1110      1120      1130      1140      1150        

      1190      1200      1210      1220      1230      1240       
pF1KB3 YIISNRWLSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YIISNRWLSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMM
     1160      1170      1180      1190      1200      1210        

      1250      1260      1270      1280      1290      1300       
pF1KB3 SDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLR
     1220      1230      1240      1250      1260      1270        

      1310      1320      1330      1340      1350      1360       
pF1KB3 DLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLT
     1280      1290      1300      1310      1320      1330        

      1370      1380      1390      1400      1410      1420       
pF1KB3 IIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLS
     1340      1350      1360      1370      1380      1390        

      1430      1440      1450      1460      1470      1480       
pF1KB3 VGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTI
     1400      1410      1420      1430      1440      1450        

      1490      1500      1510      1520       
pF1KB3 MDYTRVLVLDKGVVAEFDSPANLIAARGIFYGMARDAGLA
       ::::::::::::::::::::::::::::::::::::::::
XP_011 MDYTRVLVLDKGVVAEFDSPANLIAARGIFYGMARDAGLA
     1460      1470      1480      1490        

>>XP_011523725 (OMIM: 604323) PREDICTED: canalicular mul  (1562 aa)
 initn: 8572 init1: 7008 opt: 7008  Z-score: 7445.0  bits: 1390.3 E(85289):    0
Smith-Waterman score: 8466; 86.1% identity (90.0% similar) in 1564 aa overlap (4-1527:4-1562)

               10        20        30        40        50        60
pF1KB3 MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHC
          :::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHC
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 RGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLAT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLAT
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 LLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFAL
              130       140       150       160       170       180

              190       200       210       220               230  
pF1KB3 VLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKM--------AIYGYR
       :::::::::::::::::::::::::::::::::::::::::::::.         . :. 
XP_011 VLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKLLNPDPLRGCLPGFT
              190       200       210       220       230       240

            240                250            260       270        
pF1KB3 HPLEEKDLW---------SLKEEDRSQM-----VVQQLLEAWRKQEKQTARHKASAAP--
        : ..  ::          :  . :.:.     ..   .:   : .  :   ...     
XP_011 SP-QDGHLWLPASPGGEGPLVPKGRGQIPDGGAAAAGGMEEAGKADGTTQGFSSTWEKCL
               250       260       270       280       290         

          280           290           300       310          320   
pF1KB3 --GKNASG----EDEVLLGARP----RPRKPSFLKALLATFGSSFLI---SACFKLIQDL
         :..:.:      :.::   :    : . :   . :: .. .  :.   .:  .  :  
XP_011 RRGRGAAGCPAQAPEALLPEGPAGHLRLQLPH--QCLLQAYPGPALLHQSTAAQHPDQVY
     300       310       320       330         340       350       

           330       340       350        360       370       380  
pF1KB3 LSFINPQLLSILIRFISNPMAPSWWGFLVAGL-MFLCSMMQSLILQHYYHYIFVTGVK--
       :.  .: :...   . . :.  .  . :.. : . ::.  .    .:  :    .: .  
XP_011 LQPHGPLLVGLPGGWADVPVLHDAVADLTTLLPLHLCDWGEVSYWDHGCHLQEGSGYHQL
       360       370       380       390       400       410       

              390       400       410       420       430       440
pF1KB3 FRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILA
        .: .      .  :    . ..        ..:. :..  :: :. ..  .  : .:  
XP_011 SQTCVHCGGNCQPHVSGCPALHGPCPLPQSAVVSTPADHPGDLLPLADF-GNLSLCVIYP
       420       430       440       450       460        470      

              450       460       470       480       490       500
pF1KB3 IYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKV
            :::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PVPP-QNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKV
        480        490       500       510       520       530     

              510       520       530       540       550       560
pF1KB3 LKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPN
         540       550       560       570       580       590     

              570       580       590       600       610       620
pF1KB3 NVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKT
         600       610       620       630       640       650     

              630       640       650       660       670       680
pF1KB3 ISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEK
         660       670       680       690       700       710     

              690       700       710       720       730       740
pF1KB3 LEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGD
         720       730       740       750       760       770     

              750       760       770       780       790       800
pF1KB3 QTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVL
         780       790       800       810       820       830     

              810       820       830       840       850       860
pF1KB3 AGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGH
         840       850       860       870       880       890     

              870       880       890       900       910       920
pF1KB3 LEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRP
         900       910       920       930       940       950     

              930       940       950       960       970       980
pF1KB3 VPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTLAICLLYVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTLAICLLYVG
         960       970       980       990      1000      1010     

              990      1000      1010      1020      1030      1040
pF1KB3 QSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMAMAAGGIQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMAMAAGGIQA
        1020      1030      1040      1050      1060      1070     

             1050      1060      1070      1080      1090      1100
pF1KB3 ARVLHQALPHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAIST
       :::::::: :::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAIST
        1080      1090      1100      1110      1120      1130     

             1110      1120      1130      1140      1150      1160
pF1KB3 LVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFSETVTGASV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFSETVTGASV
        1140      1150      1160      1170      1180      1190     

             1170      1180      1190      1200      1210      1220
pF1KB3 IRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAALFAVIGRSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAALFAVIGRSS
        1200      1210      1220      1230      1240      1250     

             1230      1240      1250      1260      1270      1280
pF1KB3 LNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPP
        1260      1270      1280      1290      1300      1310     

             1290      1300      1310      1320      1330      1340
pF1KB3 EGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRIL
        1320      1330      1340      1350      1360      1370     

             1350      1360      1370      1380      1390      1400
pF1KB3 EAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALE
        1380      1390      1400      1410      1420      1430     

             1410      1420      1430      1440      1450      1460
pF1KB3 LSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLET
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLET
        1440      1450      1460      1470      1480      1490     

             1470      1480      1490      1500      1510      1520
pF1KB3 DNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIFYGM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIFYGM
        1500      1510      1520      1530      1540      1550     

              
pF1KB3 ARDAGLA
       :::::::
XP_011 ARDAGLA
        1560  

>>XP_016880755 (OMIM: 604323) PREDICTED: canalicular mul  (1271 aa)
 initn: 6655 init1: 5091 opt: 5091  Z-score: 5408.2  bits: 1013.2 E(85289):    0
Smith-Waterman score: 6549; 82.9% identity (87.7% similar) in 1272 aa overlap (4-1235:4-1270)

               10        20        30        40        50        60
pF1KB3 MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHC
          :::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHC
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 RGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLAT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLAT
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 LLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFAL
              130       140       150       160       170       180

              190       200       210       220               230  
pF1KB3 VLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKM--------AIYGYR
       :::::::::::::::::::::::::::::::::::::::::::::.         . :. 
XP_016 VLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKLLNPDPLRGCLPGFT
              190       200       210       220       230       240

            240                250            260       270        
pF1KB3 HPLEEKDLW---------SLKEEDRSQM-----VVQQLLEAWRKQEKQTARHKASAAP--
        : ..  ::          :  . :.:.     ..   .:   : .  :   ...     
XP_016 SP-QDGHLWLPASPGGEGPLVPKGRGQIPDGGAAAAGGMEEAGKADGTTQGFSSTWEKCL
               250       260       270       280       290         

          280           290           300       310          320   
pF1KB3 --GKNASG----EDEVLLGARP----RPRKPSFLKALLATFGSSFLI---SACFKLIQDL
         :..:.:      :.::   :    : . :   . :: .. .  :.   .:  .  :  
XP_016 RRGRGAAGCPAQAPEALLPEGPAGHLRLQLPH--QCLLQAYPGPALLHQSTAAQHPDQVY
     300       310       320       330         340       350       

           330       340       350        360       370       380  
pF1KB3 LSFINPQLLSILIRFISNPMAPSWWGFLVAGL-MFLCSMMQSLILQHYYHYIFVTGVK--
       :.  .: :...   . . :.  .  . :.. : . ::.  .    .:  :    .: .  
XP_016 LQPHGPLLVGLPGGWADVPVLHDAVADLTTLLPLHLCDWGEVSYWDHGCHLQEGSGYHQL
       360       370       380       390       400       410       

              390       400       410       420       430       440
pF1KB3 FRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILA
        .: .      .  :    . ..        ..:. :..  :: :. ..  .  : .:  
XP_016 SQTCVHCGGNCQPHVSGCPALHGPCPLPQSAVVSTPADHPGDLLPLADF-GNLSLCVIYP
       420       430       440       450       460        470      

              450       460       470       480       490       500
pF1KB3 IYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKV
            :::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PVPP-QNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKV
        480        490       500       510       520       530     

              510       520       530       540       550       560
pF1KB3 LKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPN
         540       550       560       570       580       590     

              570       580       590       600       610       620
pF1KB3 NVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKT
         600       610       620       630       640       650     

              630       640       650       660       670       680
pF1KB3 ISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEK
         660       670       680       690       700       710     

              690       700       710       720       730       740
pF1KB3 LEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGD
         720       730       740       750       760       770     

              750       760       770       780       790       800
pF1KB3 QTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVL
         780       790       800       810       820       830     

              810       820       830       840       850       860
pF1KB3 AGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGH
         840       850       860       870       880       890     

              870       880       890       900       910       920
pF1KB3 LEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRP
         900       910       920       930       940       950     

              930       940       950       960       970       980
pF1KB3 VPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTLAICLLYVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTLAICLLYVG
         960       970       980       990      1000      1010     

              990      1000      1010      1020      1030      1040
pF1KB3 QSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMAMAAGGIQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMAMAAGGIQA
        1020      1030      1040      1050      1060      1070     

             1050      1060      1070      1080      1090      1100
pF1KB3 ARVLHQALPHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAIST
       :::::::: :::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAIST
        1080      1090      1100      1110      1120      1130     

             1110      1120      1130      1140      1150      1160
pF1KB3 LVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFSETVTGASV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFSETVTGASV
        1140      1150      1160      1170      1180      1190     

             1170      1180      1190      1200      1210      1220
pF1KB3 IRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAALFAVIGRSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAALFAVIGRSS
        1200      1210      1220      1230      1240      1250     

             1230      1240      1250      1260      1270      1280
pF1KB3 LNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPP
       :::::::::::::::                                             
XP_016 LNPGLVGLSVSYSLQT                                            
        1260      1270                                             

>>XP_006717693 (OMIM: 237500,601107) PREDICTED: canalicu  (1313 aa)
 initn: 3477 init1: 1549 opt: 4132  Z-score: 4388.5  bits: 824.5 E(85289):    0
Smith-Waterman score: 4162; 49.8% identity (78.0% similar) in 1320 aa overlap (235-1526:1-1305)

          210       220       230       240       250        260   
pF1KB3 NPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEA-WRKQ
                                     .. : : : : : . .  .:.  .:  :.:
XP_006                               MKTKTLVS-KFETHMKRELQKARRALQRRQ
                                              10        20         

           270         280        290                 300       310
pF1KB3 EKQTARHKASAAPG--KNAS-GEDEVLLGARPRPRKPS----------FLKALLATFGSS
       ::.. .....  ::  :: : ..: ..:    . .: :          ..:::. ::   
XP_006 EKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSGTKKDVPKSWLMKALFKTFYMV
      30        40        50        60        70        80         

              320       330       340       350       360       370
pF1KB3 FLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQHY
       .: :  .::..:...:..::::..:: : :.  .  : :.: : :.:  ...::. :: :
XP_006 LLKSFLLKLVNDIFTFVSPQLLKLLISFASDRDTYLWIGYLCAILLFTAALIQSFCLQCY
      90       100       110       120       130       140         

              380       390       400       410       420       430
pF1KB3 YHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLL
       ..  :  ::: ::.::. .:.:::...: ...  :::: :::::::::..::.. :...:
XP_006 FQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGETVNLMSVDAQKLMDVTNFMHML
     150       160       170       180       190       200         

              440       450       460       470       480       490
pF1KB3 WSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKL
       ::. :::.:.:.:::..:::::::::. :::.::.:. ...: ...:::.:: ::.:.:.
XP_006 WSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQVKNMKNKDKRLKI
     210       220       230       240       250       260         

              500       510       520       530       540       550
pF1KB3 MSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLIT
       :.:::.:::.:: .::::::  ::...:. ::. : . . :. .. :... .: ::...:
XP_006 MNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQCVVIFVFQLTPVLVSVVT
     270       280       290       300       310       320         

              560       570       580       590       600       610
pF1KB3 LWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEE
       . ::: :: ::.:::.:::.:..::::::.::.:::..::.. ::::: .:....:. ..
XP_006 FSVYVLVDSNNILDAQKAFTSITLFNILRFPLSMLPMMISSMLQASVSTERLEKYLGGDD
     330       340       350       360       370       380         

              620       630       640       650       660       670
pF1KB3 LDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSL
       :: ... :.  .   :. .  ..::: .:   :........  : ::::.:::: :::::
XP_006 LDTSAI-RHDCNFDKAMQFSEASFTWEHDSEATVRDVNLDIMAGQLVAVIGPVGSGKSSL
     390        400       410       420       430       440        

              680       690       700       710       720       730
pF1KB3 VSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALL
       .::.:::::...:.. .::..::::::.:::: :...:.:::  .: :::::.:::::::
XP_006 ISAMLGEMENVHGHITIKGTTAYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACALL
      450       460       470       480       490       500        

              740       750       760       770       780       790
pF1KB3 ADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIF
        ::::::::: .:::::::::::::.::.:::::.:.. ::.::::::::::.::.::::
XP_006 PDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIF
      510       520       530       540       550       560        

              800       810       820       830       840          
pF1KB3 DHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFAN---
       ..:.::.:.: ::::.::::.. ::::.: :.::..: . : : : ::: ..: ::.   
XP_006 NKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLK
      570       580       590       600       610       620        

        850       860       870       880         890        900   
pF1KB3 -FLCNYAPDEDQGHLEDSWTALEGAEDKEALLIED--TLSNHTDLT-DNDPVTYVVQKQF
        :: . .:.:.        :. .:.:...    .:   .:.  ..  :   .:.  ...:
XP_006 TFLRHTGPEEEA-------TVHDGSEEED----DDYGLISSVEEIPEDAASITMRRENSF
      630       640              650           660       670       

           910       920       930         940        950       960
pF1KB3 MRQLSALSSDGEGQGRPVPRRHLGPSE--KVQVTEAKADGA-LTQEEKAAIGTVELSVFW
        : ::  :: ..:.     :  :   .  ...  :  . :  : ..:    : :..:.. 
XP_006 RRTLSR-SSRSNGRHLKSLRNSLKTRNVNSLKEDEELVKGQKLIKKEFIETGKVKFSIYL
       680        690       700       710       720       730      

              970       980       990      1000          1010      
pF1KB3 DYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAM----ADSRQNNTSLRLGVYA
       .: .:.:: . . : : .: .:.: ::.:.::::::.:.     .:   .. ..:.:::.
XP_006 EYLQAIGLFSIFFIILAFVMNSVAFIGSNLWLSAWTSDSKIFNSTDYPASQRDMRVGVYG
        740       750       760       770       780       790      

       1020      1030      1040      1050      1060      1070      
pF1KB3 ALGILQGFLVMLAAMAMAAGGIQAARVLHQALPHNKIRSPQSFFDTTPSGRILNCFSKDI
       :::. ::..:..: .  : : ..:. .::. : .: .:.:. ::::::.:::.: :. ::
XP_006 ALGLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIVNRFAGDI
        800       810       820       830       840       850      

       1080      1090      1100      1110      1120      1130      
pF1KB3 YVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQL
        .::..:   .   .. :.. :::::.:  .::.::....::...:. :: ::..:::::
XP_006 STVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMFYVSTSRQL
        860       870       880       890       900       910      

       1140      1150      1160      1170      1180      1190      
pF1KB3 KRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLS
       .::.::.::::::::::::.:  ::::..... :   .....:.::.  . .: :::::.
XP_006 RRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSWITSNRWLA
        920       930       940       950       960       970      

       1200      1210      1220      1230      1240      1250      
pF1KB3 IGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVA
       : .:.::: .:.:.::. :: :..:.   ::. .: .:..: .:::..:: :..:.::::
XP_006 IRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVRMTSEIETNIVA
        980       990      1000      1010      1020      1030      

       1260      1270      1280      1290      1300      1310      
pF1KB3 VERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGG
       :::. ::.:.:.:::::.. .:::  :: .:...: ::.::::: :::::: ..  . . 
XP_006 VERITEYTKVENEAPWVTD-KRPPPDWPSKGKIQFNNYQVRYRPELDLVLRGITCDIGSM
       1040      1050       1060      1070      1080      1090     

       1320      1330      1340      1350      1360      1370      
pF1KB3 EKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILF
       ::.:.::::::::::.: ::::::::: :.: :::...:.::::::: .:::::::::::
XP_006 EKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQDPILF
        1100      1110      1120      1130      1140      1150     

       1380      1390      1400      1410      1420      1430      
pF1KB3 SGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCL
       ::.::::::::..::.:.:: ::::.::..::.:   ::. . .:.: :::.:::::.::
XP_006 SGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCL
        1160      1170      1180      1190      1200      1210     

       1440      1450      1460      1470      1480      1490      
pF1KB3 ARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVL
       .:::::::.::::::::::.:::::::::.::...:  :::.::::::.::::  .:.::
XP_006 GRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVL
        1220      1230      1240      1250      1260      1270     

       1500      1510      1520              
pF1KB3 DKGVVAEFDSPANLIAARGIFYGMARDAGLA       
       :.: . :  :: .:.   : :: ::..::.        
XP_006 DNGKIIECGSPEELLQIPGPFYFMAKEAGIENVNSTKF
        1280      1290      1300      1310   

>>NP_000383 (OMIM: 237500,601107) canalicular multispeci  (1545 aa)
 initn: 3700 init1: 1549 opt: 4132  Z-score: 4387.5  bits: 824.6 E(85289):    0
Smith-Waterman score: 4452; 46.2% identity (74.8% similar) in 1557 aa overlap (12-1526:8-1537)

               10        20        30        40        50        60
pF1KB3 MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHC
                  : ::.:.. . . . ::  ::....:.:.:  .::.  :  ::.. .  
NP_000     MLEKFCNSTFWNSSF-LDSPEADLPLCFEQTVLVWIPLGFLWLLAPWQLLHVYKSR
                   10         20        30        40        50     

               70        80        90       100         110        
pF1KB3 RGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAP-VFFVTP-LVVGVTMLL
             ..:   :.:.  .:  ..  .:   .     :.: .: : ...: : .:. .:.
NP_000 TKRSSTTKLYLAKQVFVGFLLILAAIELALVLTED-SGQATVPAVRYTNPSLYLGTWLLV
          60        70        80        90        100       110    

      120       130        140       150       160       170       
pF1KB3 ATLLIQYERLQGVQ-SSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIH
         ::::: :   :: .:  : .::.: ..:.   :.. .. .  .:. :.      :.: 
NP_000 --LLIQYSRQWCVQKNSWFLSLFWILSILCGTFQFQT-LIRTLLQGDNSNLAYSCLFFIS
            120       130       140        150       160       170 

       180       190       200       210       220       230       
pF1KB3 FALVLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEE
       ... .  ::.. : :        : . .  : . :.::: . . :. .. . ::..::  
NP_000 YGFQILILIFSAFSE--------NNESSNNPSSIASFLSSITYSWYDSIILKGYKRPLTL
             180               190       200       210       220   

       240       250                   260       270         280   
pF1KB3 KDLWSLKEEDRSQMVV--------QQLLEA----WRKQEKQTARHKASAAPG--KNAS-G
       .:.: . :: ... .:        ..: .:     :.:::.. .....  ::  :: : .
NP_000 EDVWEVDEEMKTKTLVSKFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQS
           230       240       250       260       270       280   

            290                 300       310       320       330  
pF1KB3 EDEVLLGARPRPRKPS----------FLKALLATFGSSFLISACFKLIQDLLSFINPQLL
       .: ..:    . .: :          ..:::. ::   .: :  .::..:...:..::::
NP_000 QDALVLEDVEKKKKKSGTKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLL
           290       300       310       320       330       340   

            340       350       360       370       380       390  
pF1KB3 SILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRK
       ..:: : :.  .  : :.: : :.:  ...::. :: :..  :  ::: ::.::. .:.:
NP_000 KLLISFASDRDTYLWIGYLCAILLFTAALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKK
           350       360       370       380       390       400   

            400       410       420       430       440       450  
pF1KB3 ALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSV
       ::...: ...  :::: :::::::::..::.. :...:::. :::.:.:.:::..:::::
NP_000 ALTLSNLARKEYTVGETVNLMSVDAQKLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSV
           410       420       430       440       450       460   

            460       470       480       490       500       510  
pF1KB3 LAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLK
       ::::. :::.::.:. ...: ...:::.:: ::.:.:.:.:::.:::.:: .::::::  
NP_000 LAGVGVMVLVIPINAILSTKSKTIQVKNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRD
           470       480       490       500       510       520   

            520       530       540       550       560       570  
pF1KB3 QVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSV
       ::...:. ::. : . . :. .. :... .: ::...:. ::: :: ::.:::.:::.:.
NP_000 QVQNLRKKELKNLLAFSQLQCVVIFVFQLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSI
           530       540       550       560       570       580   

            580       590       600       610       620       630  
pF1KB3 SLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKTISPGYAITIHSG
       .::::::.::.:::..::.. ::::: .:....:. ..:: ... :.  .   :. .  .
NP_000 TLFNILRFPLSMLPMMISSMLQASVSTERLEKYLGGDDLDTSAI-RHDCNFDKAMQFSEA
           590       600       610       620        630       640  

            640       650       660       670       680       690  
pF1KB3 TFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVA
       .::: .:   :........  : ::::.:::: :::::.::.:::::...:.. .::..:
NP_000 SFTWEHDSEATVRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTA
            650       660       670       680       690       700  

            700       710       720       730       740       750  
pF1KB3 YVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLS
       :::::.:::: :...:.:::  .: :::::.::::::: ::::::::: .::::::::::
NP_000 YVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLS
            710       720       730       740       750       760  

            760       770       780       790       800       810  
pF1KB3 GGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGI
       :::.::.:::::.:.. ::.::::::::::.::.::::..:.::.:.: ::::.::::..
NP_000 GGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSM
            770       780       790       800       810       820  

            820       830       840           850       860        
pF1KB3 SFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFAN----FLCNYAPDEDQGHLEDSWTAL
        ::::.: :.::..: . : : : ::: ..: ::.    :: . .:.:.        :. 
NP_000 HFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKTFLRHTGPEEEA-------TVH
            830       840       850       860       870            

      870       880         890        900       910       920     
pF1KB3 EGAEDKEALLIED--TLSNHTDLT-DNDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRH
       .:.:...    .:   .:.  ..  :   .:.  ...: : ::  :: ..:.     :  
NP_000 DGSEEED----DDYGLISSVEEIPEDAASITMRRENSFRRTLSR-SSRSNGRHLKSLRNS
         880           890       900       910        920       930

         930         940        950       960       970       980  
pF1KB3 LGPSE--KVQVTEAKADGA-LTQEEKAAIGTVELSVFWDYAKAVGLCTTLAICLLYVGQS
       :   .  ...  :  . :  : ..:    : :..:.. .: .:.:: . . : : .: .:
NP_000 LKTRNVNSLKEDEELVKGQKLIKKEFIETGKVKFSIYLEYLQAIGLFSIFFIILAFVMNS
              940       950       960       970       980       990

            990      1000          1010      1020      1030        
pF1KB3 AAAIGANVWLSAWTNDAM----ADSRQNNTSLRLGVYAALGILQGFLVMLAAMAMAAGGI
       .: ::.:.::::::.:.     .:   .. ..:.:::.:::. ::..:..: .  : : .
NP_000 VAFIGSNLWLSAWTSDSKIFNSTDYPASQRDMRVGVYGALGLAQGIFVFIAHFWSAFGFV
             1000      1010      1020      1030      1040      1050

     1040      1050      1060      1070      1080      1090        
pF1KB3 QAARVLHQALPHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAI
       .:. .::. : .: .:.:. ::::::.:::.: :. :: .::..:   .   .. :.. :
NP_000 HASNILHKQLLNNILRAPMRFFDTTPTGRIVNRFAGDISTVDDTLPQSLRSWITCFLGII
             1060      1070      1080      1090      1100      1110

     1100      1110      1120      1130      1140      1150        
pF1KB3 STLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFSETVTGA
       ::::.:  .::.::....::...:. :: ::..:::::.::.::.::::::::::::.: 
NP_000 STLVMICMATPVFTIIVIPLGIIYVSVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGL
             1120      1130      1140      1150      1160      1170

     1160      1170      1180      1190      1200      1210        
pF1KB3 SVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAALFAVIGR
        ::::..... :   .....:.::.  . .: :::::.: .:.::: .:.:.::. :: :
NP_000 PVIRAFEHQQRFLKHNEVRIDTNQKCVFSWITSNRWLAIRLELVGNLTVFFSALMMVIYR
             1180      1190      1200      1210      1220      1230

     1220      1230      1240      1250      1260      1270        
pF1KB3 SSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSR
       ..:.   ::. .: .:..: .:::..:: :..:.:::::::. ::.:.:.:::::.. .:
NP_000 DTLSGDTVGFVLSNALNITQTLNWLVRMTSEIETNIVAVERITEYTKVENEAPWVTD-KR
             1240      1250      1260      1270      1280          

     1280      1290      1300      1310      1320      1330        
pF1KB3 PPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFR
       ::  :: .:...: ::.::::: :::::: ..  . . ::.:.::::::::::.: ::::
NP_000 PPPDWPSKGKIQFNNYQVRYRPELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFR
    1290      1300      1310      1320      1330      1340         

     1340      1350      1360      1370      1380      1390        
pF1KB3 ILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWA
       ::::: :.: :::...:.::::::: .:::::::::::::.::::::::..::.:.:: :
NP_000 ILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFNNYSDEEIWKA
    1350      1360      1370      1380      1390      1400         

     1400      1410      1420      1430      1440      1450        
pF1KB3 LELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDL
       :::.::..::.:   ::. . .:.: :::.:::::.::.:::::::.::::::::::.::
NP_000 LELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDL
    1410      1420      1430      1440      1450      1460         

     1460      1470      1480      1490      1500      1510        
pF1KB3 ETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIFY
       :::::::.::...:  :::.::::::.::::  .:.:::.: . :  :: .:.   : ::
NP_000 ETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGPFY
    1470      1480      1490      1500      1510      1520         

     1520              
pF1KB3 GMARDAGLA       
        ::..::.        
NP_000 FMAKEAGIENVNSTKF
    1530      1540     




1527 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 12:59:21 2016 done: Thu Nov  3 12:59:24 2016
 Total Scan time: 15.950 Total Display time:  0.890

Function used was FASTA [36.3.4 Apr, 2011]
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