Result of FASTA (omim) for pF1KB1123
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB1123, 2549 aa
  1>>>pF1KB1123 2549 - 2549 aa - 2549 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 6.4544+/-0.000536; mu= 20.0570+/- 0.034
 mean_var=84.3310+/-17.010, 0's: 0 Z-trim(108.3): 127  B-trim: 408 in 1/53
 Lambda= 0.139663
 statistics sampled from 16272 (16404) to 16272 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.517), E-opt: 0.2 (0.192), width:  16
 Scan time: 16.620

The best scores are:                                      opt bits E(85289)
NP_004949 (OMIM: 601231,616638) serine/threonine-p (2549) 16818 3400.3       0
XP_005263495 (OMIM: 601231,616638) PREDICTED: seri (2549) 16818 3400.3       0
XP_016856389 (OMIM: 601231,616638) PREDICTED: seri (2322) 15375 3109.5       0
XP_016856390 (OMIM: 601231,616638) PREDICTED: seri (2133) 14098 2852.2       0
XP_011539468 (OMIM: 601231,616638) PREDICTED: seri (1590) 10385 2104.0       0
XP_016856391 (OMIM: 601231,616638) PREDICTED: seri (1424) 9208 1866.8       0
XP_016862132 (OMIM: 210600,601215,614564) PREDICTE (2580)  625 137.5 2.2e-30
XP_011511227 (OMIM: 210600,601215,614564) PREDICTE (2582)  625 137.5 2.2e-30
NP_001175 (OMIM: 210600,601215,614564) serine/thre (2644)  625 137.5 2.3e-30
XP_011511226 (OMIM: 210600,601215,614564) PREDICTE (2646)  625 137.5 2.3e-30
XP_006718908 (OMIM: 114480,208900,607585) PREDICTE (1708)  577 127.8 1.3e-27
XP_011541147 (OMIM: 114480,208900,607585) PREDICTE (2620)  577 127.9 1.8e-27
XP_011541146 (OMIM: 114480,208900,607585) PREDICTE (2708)  577 127.9 1.9e-27
XP_011541144 (OMIM: 114480,208900,607585) PREDICTE (3001)  577 127.9 2.1e-27
XP_011541142 (OMIM: 114480,208900,607585) PREDICTE (3056)  577 127.9 2.1e-27
XP_006718906 (OMIM: 114480,208900,607585) PREDICTE (3056)  577 127.9 2.1e-27
NP_000042 (OMIM: 114480,208900,607585) serine-prot (3056)  577 127.9 2.1e-27
XP_005271619 (OMIM: 114480,208900,607585) PREDICTE (3056)  577 127.9 2.1e-27
XP_016873278 (OMIM: 114480,208900,607585) PREDICTE (3056)  577 127.9 2.1e-27
XP_016873279 (OMIM: 114480,208900,607585) PREDICTE (3056)  577 127.9 2.1e-27
XP_005271618 (OMIM: 114480,208900,607585) PREDICTE (3056)  577 127.9 2.1e-27
XP_011541145 (OMIM: 114480,208900,607585) PREDICTE (2912)  370 86.2 7.3e-15
XP_016878556 (OMIM: 607032) PREDICTED: serine/thre (3059)  328 77.7 2.7e-12
XP_011544072 (OMIM: 607032) PREDICTED: serine/thre (3059)  328 77.7 2.7e-12
XP_005255241 (OMIM: 607032) PREDICTED: serine/thre (3637)  328 77.7 3.1e-12
NP_055907 (OMIM: 607032) serine/threonine-protein  (3661)  328 77.7 3.2e-12
XP_016878555 (OMIM: 607032) PREDICTED: serine/thre (3663)  328 77.7 3.2e-12
XP_005255240 (OMIM: 607032) PREDICTED: serine/thre (3663)  328 77.7 3.2e-12
XP_011544071 (OMIM: 607032) PREDICTED: serine/thre (3688)  328 77.7 3.2e-12
XP_005255239 (OMIM: 607032) PREDICTED: serine/thre (3689)  328 77.7 3.2e-12
NP_008835 (OMIM: 600899,615966) DNA-dependent prot (4128)  305 73.1 8.7e-11
NP_001075109 (OMIM: 600899,615966) DNA-dependent p (4097)  271 66.3   1e-08
XP_011524333 (OMIM: 602609) PREDICTED: phosphatidy ( 701)  206 52.9 1.8e-05
NP_001294949 (OMIM: 602609) phosphatidylinositol 3 ( 824)  206 52.9 2.1e-05
NP_002638 (OMIM: 602609) phosphatidylinositol 3-ki ( 887)  206 53.0 2.2e-05
NP_001242974 (OMIM: 602925) phosphatidylinositol 4 ( 582)  191 49.9 0.00012
XP_016862110 (OMIM: 602925) PREDICTED: phosphatidy ( 657)  191 49.9 0.00014
XP_016862109 (OMIM: 602925) PREDICTED: phosphatidy ( 674)  191 49.9 0.00014
XP_016856974 (OMIM: 602839,615513) PREDICTED: phos (1015)  193 50.4 0.00015
XP_016856973 (OMIM: 602839,615513) PREDICTED: phos (1043)  193 50.4 0.00016
XP_006710752 (OMIM: 602839,615513) PREDICTED: phos (1044)  193 50.4 0.00016
XP_006710750 (OMIM: 602839,615513) PREDICTED: phos (1044)  193 50.4 0.00016
NP_005017 (OMIM: 602839,615513) phosphatidylinosit (1044)  193 50.4 0.00016
XP_016856972 (OMIM: 602839,615513) PREDICTED: phos (1074)  193 50.4 0.00016
XP_016856967 (OMIM: 602839,615513) PREDICTED: phos (1103)  193 50.4 0.00016
XP_016856970 (OMIM: 602839,615513) PREDICTED: phos (1103)  193 50.4 0.00016
XP_016856971 (OMIM: 602839,615513) PREDICTED: phos (1103)  193 50.4 0.00016
XP_016856965 (OMIM: 602839,615513) PREDICTED: phos (1103)  193 50.4 0.00016
XP_016856966 (OMIM: 602839,615513) PREDICTED: phos (1103)  193 50.4 0.00016
XP_016856969 (OMIM: 602839,615513) PREDICTED: phos (1103)  193 50.4 0.00016


>>NP_004949 (OMIM: 601231,616638) serine/threonine-prote  (2549 aa)
 initn: 16818 init1: 16818 opt: 16818  Z-score: 18299.8  bits: 3400.3 E(85289):    0
Smith-Waterman score: 16818; 100.0% identity (100.0% similar) in 2549 aa overlap (1-2549:1-2549)

               10        20        30        40        50        60
pF1KB1 MLGTGPAAATTAATTSSNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MLGTGPAAATTAATTSSNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEES
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB1 TRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSNDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSNDP
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB1 VVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB1 TFFFQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLILTTQREPKEMQKPQWYRHTFEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TFFFQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLILTTQREPKEMQKPQWYRHTFEE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB1 AEKGFDETLAKEKGMNRDDRIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKYC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 AEKGFDETLAKEKGMNRDDRIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKYC
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB1 KDLMGFGTKPRHITPFTSFQAVQPQQSNALVGLLGYSSHQGLMGFGTSPSPAKSTLVESR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KDLMGFGTKPRHITPFTSFQAVQPQQSNALVGLLGYSSHQGLMGFGTSPSPAKSTLVESR
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB1 CCRDLMEEKFDQVCQWVLKCRNSKNSLIQMTILNLLPRLAAFRPSAFTDTQYLQDTMNHV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 CCRDLMEEKFDQVCQWVLKCRNSKNSLIQMTILNLLPRLAAFRPSAFTDTQYLQDTMNHV
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB1 LSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKAMQVDA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKAMQVDA
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB1 TVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLL
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB1 KMLSLVLMHKPLRHPGMPKGLAHQLASPGLTTLPEASDVGSITLALRTLGSFEFEGHSLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KMLSLVLMHKPLRHPGMPKGLAHQLASPGLTTLPEASDVGSITLALRTLGSFEFEGHSLT
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB1 QFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLL
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB1 VVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSS
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB1 MNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALI
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB1 LKLKDPDPDPNPGVINNVLATIGELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LKLKDPDPDPNPGVINNVLATIGELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVA
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB1 LWTLGQLVASTGYVVELYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHK
       :::::::::::::::: :::::::::::::::::::::::::::::::::::::::::::
NP_004 LWTLGQLVASTGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHK
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KB1 VNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFR
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KB1 DQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 DQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLV
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KB1 SFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLR
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KB1 VFMHDNSPGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPEAPLPSRKAALETVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VFMHDNSPGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPEAPLPSRKAALETVD
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KB1 RLTESLDFTDYASRIIHPIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 RLTESLDFTDYASRIIHPIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLV
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KB1 RHRINHQRYDVLICRIVKGYTLADEEEDPLIYQHRMLRSGQGDALASGPVETGPMKKLHV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 RHRINHQRYDVLICRIVKGYTLADEEEDPLIYQHRMLRSGQGDALASGPVETGPMKKLHV
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KB1 STINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 STINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNA
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KB1 AFVSCWSELNEDQQDELIRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 AFVSCWSELNEDQQDELIRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGI
             1330      1340      1350      1360      1370      1380

             1390      1400      1410      1420      1430      1440
pF1KB1 VLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHF
             1390      1400      1410      1420      1430      1440

             1450      1460      1470      1480      1490      1500
pF1KB1 GELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEK
             1450      1460      1470      1480      1490      1500

             1510      1520      1530      1540      1550      1560
pF1KB1 WTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 WTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLA
             1510      1520      1530      1540      1550      1560

             1570      1580      1590      1600      1610      1620
pF1KB1 QQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEEVIQYKLVPERREIIRQIWW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEEVIQYKLVPERREIIRQIWW
             1570      1580      1590      1600      1610      1620

             1630      1640      1650      1660      1670      1680
pF1KB1 ERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASLCGKSGRLALAHKTLVLLLGVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 ERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASLCGKSGRLALAHKTLVLLLGVD
             1630      1640      1650      1660      1670      1680

             1690      1700      1710      1720      1730      1740
pF1KB1 PSRQLDHPLPTVHPQVTYAYMKNMWKSARKIDAFQHMQHFVQTMQQQAQHAIATEDQQHK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 PSRQLDHPLPTVHPQVTYAYMKNMWKSARKIDAFQHMQHFVQTMQQQAQHAIATEDQQHK
             1690      1700      1710      1720      1730      1740

             1750      1760      1770      1780      1790      1800
pF1KB1 QELHKLMARCFLKLGEWQLNLQGINESTIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QELHKLMARCFLKLGEWQLNLQGINESTIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEA
             1750      1760      1770      1780      1790      1800

             1810      1820      1830      1840      1850      1860
pF1KB1 VLHYKHQNQARDEKKKLRHASGANITNATTAATTAATATTTASTEGSNSESEAESTENSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VLHYKHQNQARDEKKKLRHASGANITNATTAATTAATATTTASTEGSNSESEAESTENSP
             1810      1820      1830      1840      1850      1860

             1870      1880      1890      1900      1910      1920
pF1KB1 TPSPLQKKVTEDLSKTLLMYTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDVN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TPSPLQKKVTEDLSKTLLMYTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDVN
             1870      1880      1890      1900      1910      1920

             1930      1940      1950      1960      1970      1980
pF1KB1 EALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVAS
             1930      1940      1950      1960      1970      1980

             1990      2000      2010      2020      2030      2040
pF1KB1 KSTTTARHNAANKILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KSTTTARHNAANKILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFG
             1990      2000      2010      2020      2030      2040

             2050      2060      2070      2080      2090      2100
pF1KB1 ERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 ERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQA
             2050      2060      2070      2080      2090      2100

             2110      2120      2130      2140      2150      2160
pF1KB1 WDLYYHVFRRISKQLPQLTSLELQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 WDLYYHVFRRISKQLPQLTSLELQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSL
             2110      2120      2130      2140      2150      2160

             2170      2180      2190      2200      2210      2220
pF1KB1 QVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNL
             2170      2180      2190      2200      2210      2220

             2230      2240      2250      2260      2270      2280
pF1KB1 SIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLTL
             2230      2240      2250      2260      2270      2280

             2290      2300      2310      2320      2330      2340
pF1KB1 MQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRH
             2290      2300      2310      2320      2330      2340

             2350      2360      2370      2380      2390      2400
pF1KB1 PSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRITC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 PSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRITC
             2350      2360      2370      2380      2390      2400

             2410      2420      2430      2440      2450      2460
pF1KB1 HTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 HTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILDG
             2410      2420      2430      2440      2450      2460

             2470      2480      2490      2500      2510      2520
pF1KB1 VELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDDTLD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDDTLD
             2470      2480      2490      2500      2510      2520

             2530      2540         
pF1KB1 VPTQVELLIKQATSHENLCQCYIGWCPFW
       :::::::::::::::::::::::::::::
NP_004 VPTQVELLIKQATSHENLCQCYIGWCPFW
             2530      2540         

>>XP_005263495 (OMIM: 601231,616638) PREDICTED: serine/t  (2549 aa)
 initn: 16818 init1: 16818 opt: 16818  Z-score: 18299.8  bits: 3400.3 E(85289):    0
Smith-Waterman score: 16818; 100.0% identity (100.0% similar) in 2549 aa overlap (1-2549:1-2549)

               10        20        30        40        50        60
pF1KB1 MLGTGPAAATTAATTSSNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MLGTGPAAATTAATTSSNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEES
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB1 TRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSNDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSNDP
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB1 VVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB1 TFFFQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLILTTQREPKEMQKPQWYRHTFEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TFFFQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLILTTQREPKEMQKPQWYRHTFEE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB1 AEKGFDETLAKEKGMNRDDRIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKYC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AEKGFDETLAKEKGMNRDDRIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKYC
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB1 KDLMGFGTKPRHITPFTSFQAVQPQQSNALVGLLGYSSHQGLMGFGTSPSPAKSTLVESR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KDLMGFGTKPRHITPFTSFQAVQPQQSNALVGLLGYSSHQGLMGFGTSPSPAKSTLVESR
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB1 CCRDLMEEKFDQVCQWVLKCRNSKNSLIQMTILNLLPRLAAFRPSAFTDTQYLQDTMNHV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CCRDLMEEKFDQVCQWVLKCRNSKNSLIQMTILNLLPRLAAFRPSAFTDTQYLQDTMNHV
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB1 LSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKAMQVDA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKAMQVDA
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB1 TVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLL
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB1 KMLSLVLMHKPLRHPGMPKGLAHQLASPGLTTLPEASDVGSITLALRTLGSFEFEGHSLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KMLSLVLMHKPLRHPGMPKGLAHQLASPGLTTLPEASDVGSITLALRTLGSFEFEGHSLT
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB1 QFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLL
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB1 VVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSS
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB1 MNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALI
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB1 LKLKDPDPDPNPGVINNVLATIGELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LKLKDPDPDPNPGVINNVLATIGELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVA
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB1 LWTLGQLVASTGYVVELYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHK
       :::::::::::::::: :::::::::::::::::::::::::::::::::::::::::::
XP_005 LWTLGQLVASTGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHK
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KB1 VNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFR
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KB1 DQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLV
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KB1 SFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLR
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KB1 VFMHDNSPGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPEAPLPSRKAALETVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VFMHDNSPGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPEAPLPSRKAALETVD
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KB1 RLTESLDFTDYASRIIHPIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RLTESLDFTDYASRIIHPIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLV
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KB1 RHRINHQRYDVLICRIVKGYTLADEEEDPLIYQHRMLRSGQGDALASGPVETGPMKKLHV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RHRINHQRYDVLICRIVKGYTLADEEEDPLIYQHRMLRSGQGDALASGPVETGPMKKLHV
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KB1 STINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 STINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNA
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KB1 AFVSCWSELNEDQQDELIRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AFVSCWSELNEDQQDELIRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGI
             1330      1340      1350      1360      1370      1380

             1390      1400      1410      1420      1430      1440
pF1KB1 VLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHF
             1390      1400      1410      1420      1430      1440

             1450      1460      1470      1480      1490      1500
pF1KB1 GELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEK
             1450      1460      1470      1480      1490      1500

             1510      1520      1530      1540      1550      1560
pF1KB1 WTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLA
             1510      1520      1530      1540      1550      1560

             1570      1580      1590      1600      1610      1620
pF1KB1 QQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEEVIQYKLVPERREIIRQIWW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEEVIQYKLVPERREIIRQIWW
             1570      1580      1590      1600      1610      1620

             1630      1640      1650      1660      1670      1680
pF1KB1 ERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASLCGKSGRLALAHKTLVLLLGVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASLCGKSGRLALAHKTLVLLLGVD
             1630      1640      1650      1660      1670      1680

             1690      1700      1710      1720      1730      1740
pF1KB1 PSRQLDHPLPTVHPQVTYAYMKNMWKSARKIDAFQHMQHFVQTMQQQAQHAIATEDQQHK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PSRQLDHPLPTVHPQVTYAYMKNMWKSARKIDAFQHMQHFVQTMQQQAQHAIATEDQQHK
             1690      1700      1710      1720      1730      1740

             1750      1760      1770      1780      1790      1800
pF1KB1 QELHKLMARCFLKLGEWQLNLQGINESTIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QELHKLMARCFLKLGEWQLNLQGINESTIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEA
             1750      1760      1770      1780      1790      1800

             1810      1820      1830      1840      1850      1860
pF1KB1 VLHYKHQNQARDEKKKLRHASGANITNATTAATTAATATTTASTEGSNSESEAESTENSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VLHYKHQNQARDEKKKLRHASGANITNATTAATTAATATTTASTEGSNSESEAESTENSP
             1810      1820      1830      1840      1850      1860

             1870      1880      1890      1900      1910      1920
pF1KB1 TPSPLQKKVTEDLSKTLLMYTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDVN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TPSPLQKKVTEDLSKTLLMYTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDVN
             1870      1880      1890      1900      1910      1920

             1930      1940      1950      1960      1970      1980
pF1KB1 EALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVAS
             1930      1940      1950      1960      1970      1980

             1990      2000      2010      2020      2030      2040
pF1KB1 KSTTTARHNAANKILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KSTTTARHNAANKILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFG
             1990      2000      2010      2020      2030      2040

             2050      2060      2070      2080      2090      2100
pF1KB1 ERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQA
             2050      2060      2070      2080      2090      2100

             2110      2120      2130      2140      2150      2160
pF1KB1 WDLYYHVFRRISKQLPQLTSLELQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WDLYYHVFRRISKQLPQLTSLELQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSL
             2110      2120      2130      2140      2150      2160

             2170      2180      2190      2200      2210      2220
pF1KB1 QVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNL
             2170      2180      2190      2200      2210      2220

             2230      2240      2250      2260      2270      2280
pF1KB1 SIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLTL
             2230      2240      2250      2260      2270      2280

             2290      2300      2310      2320      2330      2340
pF1KB1 MQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRH
             2290      2300      2310      2320      2330      2340

             2350      2360      2370      2380      2390      2400
pF1KB1 PSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRITC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRITC
             2350      2360      2370      2380      2390      2400

             2410      2420      2430      2440      2450      2460
pF1KB1 HTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILDG
             2410      2420      2430      2440      2450      2460

             2470      2480      2490      2500      2510      2520
pF1KB1 VELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDDTLD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDDTLD
             2470      2480      2490      2500      2510      2520

             2530      2540         
pF1KB1 VPTQVELLIKQATSHENLCQCYIGWCPFW
       :::::::::::::::::::::::::::::
XP_005 VPTQVELLIKQATSHENLCQCYIGWCPFW
             2530      2540         

>>XP_016856389 (OMIM: 601231,616638) PREDICTED: serine/t  (2322 aa)
 initn: 15375 init1: 15375 opt: 15375  Z-score: 16729.1  bits: 3109.5 E(85289):    0
Smith-Waterman score: 15375; 100.0% identity (100.0% similar) in 2322 aa overlap (228-2549:1-2322)

       200       210       220       230       240       250       
pF1KB1 VWDPKQAIREGAVAALRACLILTTQREPKEMQKPQWYRHTFEEAEKGFDETLAKEKGMNR
                                     ::::::::::::::::::::::::::::::
XP_016                               MQKPQWYRHTFEEAEKGFDETLAKEKGMNR
                                             10        20        30

       260       270       280       290       300       310       
pF1KB1 DDRIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKYCKDLMGFGTKPRHITPFT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DDRIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKYCKDLMGFGTKPRHITPFT
               40        50        60        70        80        90

       320       330       340       350       360       370       
pF1KB1 SFQAVQPQQSNALVGLLGYSSHQGLMGFGTSPSPAKSTLVESRCCRDLMEEKFDQVCQWV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SFQAVQPQQSNALVGLLGYSSHQGLMGFGTSPSPAKSTLVESRCCRDLMEEKFDQVCQWV
              100       110       120       130       140       150

       380       390       400       410       420       430       
pF1KB1 LKCRNSKNSLIQMTILNLLPRLAAFRPSAFTDTQYLQDTMNHVLSCVKKEKERTAAFQAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKCRNSKNSLIQMTILNLLPRLAAFRPSAFTDTQYLQDTMNHVLSCVKKEKERTAAFQAL
              160       170       180       190       200       210

       440       450       460       470       480       490       
pF1KB1 GLLSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKAMQVDATVFTCISMLARAMGPGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLLSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKAMQVDATVFTCISMLARAMGPGI
              220       230       240       250       260       270

       500       510       520       530       540       550       
pF1KB1 QQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLLKMLSLVLMHKPLRHPGM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLLKMLSLVLMHKPLRHPGM
              280       290       300       310       320       330

       560       570       580       590       600       610       
pF1KB1 PKGLAHQLASPGLTTLPEASDVGSITLALRTLGSFEFEGHSLTQFVRHCADHFLNSEHKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PKGLAHQLASPGLTTLPEASDVGSITLALRTLGSFEFEGHSLTQFVRHCADHFLNSEHKE
              340       350       360       370       380       390

       620       630       640       650       660       670       
pF1KB1 IRMEAARTCSRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLLVVGITDPDPDIRYCVLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IRMEAARTCSRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLLVVGITDPDPDIRYCVLA
              400       410       420       430       440       450

       680       690       700       710       720       730       
pF1KB1 SLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSSMNPAFVMPFLRKMLIQI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSSMNPAFVMPFLRKMLIQI
              460       470       480       490       500       510

       740       750       760       770       780       790       
pF1KB1 LTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALILKLKDPDPDPNPGVINN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALILKLKDPDPDPNPGVINN
              520       530       540       550       560       570

       800       810       820       830       840       850       
pF1KB1 VLATIGELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVALWTLGQLVASTGYVVEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: 
XP_016 VLATIGELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVALWTLGQLVASTGYVVEP
              580       590       600       610       620       630

       860       870       880       890       900       910       
pF1KB1 YRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHKVNIGMIDQSRDASAVSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHKVNIGMIDQSRDASAVSL
              640       650       660       670       680       690

       920       930       940       950       960       970       
pF1KB1 SESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFRDQSLSHHHTMVVQAITF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFRDQSLSHHHTMVVQAITF
              700       710       720       730       740       750

       980       990      1000      1010      1020      1030       
pF1KB1 IFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLVSFVKSHIRPYMDEIVTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLVSFVKSHIRPYMDEIVTL
              760       770       780       790       800       810

      1040      1050      1060      1070      1080      1090       
pF1KB1 MREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLRVFMHDNSPGRIVSIKLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLRVFMHDNSPGRIVSIKLL
              820       830       840       850       860       870

      1100      1110      1120      1130      1140      1150       
pF1KB1 AAIQLFGANLDDYLHLLLPPIVKLFDAPEAPLPSRKAALETVDRLTESLDFTDYASRIIH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAIQLFGANLDDYLHLLLPPIVKLFDAPEAPLPSRKAALETVDRLTESLDFTDYASRIIH
              880       890       900       910       920       930

      1160      1170      1180      1190      1200      1210       
pF1KB1 PIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLVRHRINHQRYDVLICRIV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLVRHRINHQRYDVLICRIV
              940       950       960       970       980       990

      1220      1230      1240      1250      1260      1270       
pF1KB1 KGYTLADEEEDPLIYQHRMLRSGQGDALASGPVETGPMKKLHVSTINLQKAWGAARRVSK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KGYTLADEEEDPLIYQHRMLRSGQGDALASGPVETGPMKKLHVSTINLQKAWGAARRVSK
             1000      1010      1020      1030      1040      1050

      1280      1290      1300      1310      1320      1330       
pF1KB1 DDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNAAFVSCWSELNEDQQDEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNAAFVSCWSELNEDQQDEL
             1060      1070      1080      1090      1100      1110

      1340      1350      1360      1370      1380      1390       
pF1KB1 IRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGIVLLGERAAKCRAYAKAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGIVLLGERAAKCRAYAKAL
             1120      1130      1140      1150      1160      1170

      1400      1410      1420      1430      1440      1450       
pF1KB1 HYKELEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHFGELEIQATWYEKLHEWE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HYKELEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHFGELEIQATWYEKLHEWE
             1180      1190      1200      1210      1220      1230

      1460      1470      1480      1490      1500      1510       
pF1KB1 DALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEKWTLVNDETQAKMARMAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEKWTLVNDETQAKMARMAA
             1240      1250      1260      1270      1280      1290

      1520      1530      1540      1550      1560      1570       
pF1KB1 AAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLAQQCIDKARDLLDAELTA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLAQQCIDKARDLLDAELTA
             1300      1310      1320      1330      1340      1350

      1580      1590      1600      1610      1620      1630       
pF1KB1 MAGESYSRAYGAMVSCHMLSELEEVIQYKLVPERREIIRQIWWERLQGCQRIVEDWQKIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAGESYSRAYGAMVSCHMLSELEEVIQYKLVPERREIIRQIWWERLQGCQRIVEDWQKIL
             1360      1370      1380      1390      1400      1410

      1640      1650      1660      1670      1680      1690       
pF1KB1 MVRSLVVSPHEDMRTWLKYASLCGKSGRLALAHKTLVLLLGVDPSRQLDHPLPTVHPQVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MVRSLVVSPHEDMRTWLKYASLCGKSGRLALAHKTLVLLLGVDPSRQLDHPLPTVHPQVT
             1420      1430      1440      1450      1460      1470

      1700      1710      1720      1730      1740      1750       
pF1KB1 YAYMKNMWKSARKIDAFQHMQHFVQTMQQQAQHAIATEDQQHKQELHKLMARCFLKLGEW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YAYMKNMWKSARKIDAFQHMQHFVQTMQQQAQHAIATEDQQHKQELHKLMARCFLKLGEW
             1480      1490      1500      1510      1520      1530

      1760      1770      1780      1790      1800      1810       
pF1KB1 QLNLQGINESTIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEAVLHYKHQNQARDEKKKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLNLQGINESTIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEAVLHYKHQNQARDEKKKL
             1540      1550      1560      1570      1580      1590

      1820      1830      1840      1850      1860      1870       
pF1KB1 RHASGANITNATTAATTAATATTTASTEGSNSESEAESTENSPTPSPLQKKVTEDLSKTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RHASGANITNATTAATTAATATTTASTEGSNSESEAESTENSPTPSPLQKKVTEDLSKTL
             1600      1610      1620      1630      1640      1650

      1880      1890      1900      1910      1920      1930       
pF1KB1 LMYTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDVNEALVEGVKAIQIDTWLQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LMYTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDVNEALVEGVKAIQIDTWLQ
             1660      1670      1680      1690      1700      1710

      1940      1950      1960      1970      1980      1990       
pF1KB1 VIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVASKSTTTARHNAANKILKN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVASKSTTTARHNAANKILKN
             1720      1730      1740      1750      1760      1770

      2000      2010      2020      2030      2040      2050       
pF1KB1 MCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAM
             1780      1790      1800      1810      1820      1830

      2060      2070      2080      2090      2100      2110       
pF1KB1 MERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQLPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQLPQ
             1840      1850      1860      1870      1880      1890

      2120      2130      2140      2150      2160      2170       
pF1KB1 LTSLELQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSLQVITSKQRPRKLTLMGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTSLELQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSLQVITSKQRPRKLTLMGS
             1900      1910      1920      1930      1940      1950

      2180      2190      2200      2210      2220      2230       
pF1KB1 NGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLI
             1960      1970      1980      1990      2000      2010

      2240      2250      2260      2270      2280      2290       
pF1KB1 GWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGD
             2020      2030      2040      2050      2060      2070

      2300      2310      2320      2330      2340      2350       
pF1KB1 DLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHID
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHID
             2080      2090      2100      2110      2120      2130

      2360      2370      2380      2390      2400      2410       
pF1KB1 FGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRITCHTVMEVLREHKDSVMAV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRITCHTVMEVLREHKDSVMAV
             2140      2150      2160      2170      2180      2190

      2420      2430      2440      2450      2460      2470       
pF1KB1 LEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILDGVELGEPAHKKTGTTVPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILDGVELGEPAHKKTGTTVPE
             2200      2210      2220      2230      2240      2250

      2480      2490      2500      2510      2520      2530       
pF1KB1 SIHSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDDTLDVPTQVELLIKQATSHEN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SIHSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDDTLDVPTQVELLIKQATSHEN
             2260      2270      2280      2290      2300      2310

      2540         
pF1KB1 LCQCYIGWCPFW
       ::::::::::::
XP_016 LCQCYIGWCPFW
             2320  

>>XP_016856390 (OMIM: 601231,616638) PREDICTED: serine/t  (2133 aa)
 initn: 14098 init1: 14098 opt: 14098  Z-score: 15339.1  bits: 2852.2 E(85289):    0
Smith-Waterman score: 14098; 100.0% identity (100.0% similar) in 2133 aa overlap (417-2549:1-2133)

        390       400       410       420       430       440      
pF1KB1 LIQMTILNLLPRLAAFRPSAFTDTQYLQDTMNHVLSCVKKEKERTAAFQALGLLSVAVRS
                                     ::::::::::::::::::::::::::::::
XP_016                               MNHVLSCVKKEKERTAAFQALGLLSVAVRS
                                             10        20        30

        450       460       470       480       490       500      
pF1KB1 EFKVYLPRVLDIIRAALPPKDFAHKRQKAMQVDATVFTCISMLARAMGPGIQQDIKELLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EFKVYLPRVLDIIRAALPPKDFAHKRQKAMQVDATVFTCISMLARAMGPGIQQDIKELLE
               40        50        60        70        80        90

        510       520       530       540       550       560      
pF1KB1 PMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLLKMLSLVLMHKPLRHPGMPKGLAHQLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLLKMLSLVLMHKPLRHPGMPKGLAHQLA
              100       110       120       130       140       150

        570       580       590       600       610       620      
pF1KB1 SPGLTTLPEASDVGSITLALRTLGSFEFEGHSLTQFVRHCADHFLNSEHKEIRMEAARTC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPGLTTLPEASDVGSITLALRTLGSFEFEGHSLTQFVRHCADHFLNSEHKEIRMEAARTC
              160       170       180       190       200       210

        630       640       650       660       670       680      
pF1KB1 SRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLLVVGITDPDPDIRYCVLASLDERFDAH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLLVVGITDPDPDIRYCVLASLDERFDAH
              220       230       240       250       260       270

        690       700       710       720       730       740      
pF1KB1 LAQAENLQALFVALNDQVFEIRELAICTVGRLSSMNPAFVMPFLRKMLIQILTELEHSGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAQAENLQALFVALNDQVFEIRELAICTVGRLSSMNPAFVMPFLRKMLIQILTELEHSGI
              280       290       300       310       320       330

        750       760       770       780       790       800      
pF1KB1 GRIKEQSARMLGHLVSNAPRLIRPYMEPILKALILKLKDPDPDPNPGVINNVLATIGELA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRIKEQSARMLGHLVSNAPRLIRPYMEPILKALILKLKDPDPDPNPGVINNVLATIGELA
              340       350       360       370       380       390

        810       820       830       840       850       860      
pF1KB1 QVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVALWTLGQLVASTGYVVELYRKYPTLLE
       :::::::::::::::::::::::::::::::::::::::::::::::::: :::::::::
XP_016 QVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVALWTLGQLVASTGYVVEPYRKYPTLLE
              400       410       420       430       440       450

        870       880       890       900       910       920      
pF1KB1 VLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHKVNIGMIDQSRDASAVSLSESKSSQDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHKVNIGMIDQSRDASAVSLSESKSSQDS
              460       470       480       490       500       510

        930       940       950       960       970       980      
pF1KB1 SDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFRDQSLSHHHTMVVQAITFIFKSLGLKC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFRDQSLSHHHTMVVQAITFIFKSLGLKC
              520       530       540       550       560       570

        990      1000      1010      1020      1030      1040      
pF1KB1 VQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLVSFVKSHIRPYMDEIVTLMREFWVMNT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLVSFVKSHIRPYMDEIVTLMREFWVMNT
              580       590       600       610       620       630

       1050      1060      1070      1080      1090      1100      
pF1KB1 SIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLRVFMHDNSPGRIVSIKLLAAIQLFGAN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLRVFMHDNSPGRIVSIKLLAAIQLFGAN
              640       650       660       670       680       690

       1110      1120      1130      1140      1150      1160      
pF1KB1 LDDYLHLLLPPIVKLFDAPEAPLPSRKAALETVDRLTESLDFTDYASRIIHPIVRTLDQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDDYLHLLLPPIVKLFDAPEAPLPSRKAALETVDRLTESLDFTDYASRIIHPIVRTLDQS
              700       710       720       730       740       750

       1170      1180      1190      1200      1210      1220      
pF1KB1 PELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLVRHRINHQRYDVLICRIVKGYTLADEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLVRHRINHQRYDVLICRIVKGYTLADEE
              760       770       780       790       800       810

       1230      1240      1250      1260      1270      1280      
pF1KB1 EDPLIYQHRMLRSGQGDALASGPVETGPMKKLHVSTINLQKAWGAARRVSKDDWLEWLRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDPLIYQHRMLRSGQGDALASGPVETGPMKKLHVSTINLQKAWGAARRVSKDDWLEWLRR
              820       830       840       850       860       870

       1290      1300      1310      1320      1330      1340      
pF1KB1 LSLELLKDSSSPSLRSCWALAQAYNPMARDLFNAAFVSCWSELNEDQQDELIRSIELALT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSLELLKDSSSPSLRSCWALAQAYNPMARDLFNAAFVSCWSELNEDQQDELIRSIELALT
              880       890       900       910       920       930

       1350      1360      1370      1380      1390      1400      
pF1KB1 SQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGIVLLGERAAKCRAYAKALHYKELEFQK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGIVLLGERAAKCRAYAKALHYKELEFQK
              940       950       960       970       980       990

       1410      1420      1430      1440      1450      1460      
pF1KB1 GPTPAILESLISINNKLQQPEAAAGVLEYAMKHFGELEIQATWYEKLHEWEDALVAYDKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPTPAILESLISINNKLQQPEAAAGVLEYAMKHFGELEIQATWYEKLHEWEDALVAYDKK
             1000      1010      1020      1030      1040      1050

       1470      1480      1490      1500      1510      1520      
pF1KB1 MDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEKWTLVNDETQAKMARMAAAAAWGLGQW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEKWTLVNDETQAKMARMAAAAAWGLGQW
             1060      1070      1080      1090      1100      1110

       1530      1540      1550      1560      1570      1580      
pF1KB1 DSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLAQQCIDKARDLLDAELTAMAGESYSRA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLAQQCIDKARDLLDAELTAMAGESYSRA
             1120      1130      1140      1150      1160      1170

       1590      1600      1610      1620      1630      1640      
pF1KB1 YGAMVSCHMLSELEEVIQYKLVPERREIIRQIWWERLQGCQRIVEDWQKILMVRSLVVSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YGAMVSCHMLSELEEVIQYKLVPERREIIRQIWWERLQGCQRIVEDWQKILMVRSLVVSP
             1180      1190      1200      1210      1220      1230

       1650      1660      1670      1680      1690      1700      
pF1KB1 HEDMRTWLKYASLCGKSGRLALAHKTLVLLLGVDPSRQLDHPLPTVHPQVTYAYMKNMWK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HEDMRTWLKYASLCGKSGRLALAHKTLVLLLGVDPSRQLDHPLPTVHPQVTYAYMKNMWK
             1240      1250      1260      1270      1280      1290

       1710      1720      1730      1740      1750      1760      
pF1KB1 SARKIDAFQHMQHFVQTMQQQAQHAIATEDQQHKQELHKLMARCFLKLGEWQLNLQGINE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SARKIDAFQHMQHFVQTMQQQAQHAIATEDQQHKQELHKLMARCFLKLGEWQLNLQGINE
             1300      1310      1320      1330      1340      1350

       1770      1780      1790      1800      1810      1820      
pF1KB1 STIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEAVLHYKHQNQARDEKKKLRHASGANIT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 STIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEAVLHYKHQNQARDEKKKLRHASGANIT
             1360      1370      1380      1390      1400      1410

       1830      1840      1850      1860      1870      1880      
pF1KB1 NATTAATTAATATTTASTEGSNSESEAESTENSPTPSPLQKKVTEDLSKTLLMYTVPAVQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NATTAATTAATATTTASTEGSNSESEAESTENSPTPSPLQKKVTEDLSKTLLMYTVPAVQ
             1420      1430      1440      1450      1460      1470

       1890      1900      1910      1920      1930      1940      
pF1KB1 GFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDVNEALVEGVKAIQIDTWLQVIPQLIARI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDVNEALVEGVKAIQIDTWLQVIPQLIARI
             1480      1490      1500      1510      1520      1530

       1950      1960      1970      1980      1990      2000      
pF1KB1 DTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVASKSTTTARHNAANKILKNMCEHSNTLV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVASKSTTTARHNAANKILKNMCEHSNTLV
             1540      1550      1560      1570      1580      1590

       2010      2020      2030      2040      2050      2060      
pF1KB1 QQAMMVSEELIRVAILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQAMMVSEELIRVAILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLK
             1600      1610      1620      1630      1640      1650

       2070      2080      2090      2100      2110      2120      
pF1KB1 ETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQLPQLTSLELQYV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQLPQLTSLELQYV
             1660      1670      1680      1690      1700      1710

       2130      2140      2150      2160      2170      2180      
pF1KB1 SPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLL
             1720      1730      1740      1750      1760      1770

       2190      2200      2210      2220      2230      2240      
pF1KB1 KGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTL
             1780      1790      1800      1810      1820      1830

       2250      2260      2270      2280      2290      2300      
pF1KB1 HALIRDYREKKKILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HALIRDYREKKKILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLK
             1840      1850      1860      1870      1880      1890

       2310      2320      2330      2340      2350      2360      
pF1KB1 SPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAM
             1900      1910      1920      1930      1940      1950

       2370      2380      2390      2400      2410      2420      
pF1KB1 TREKFPEKIPFRLTRMLTNAMEVTGLDGNYRITCHTVMEVLREHKDSVMAVLEAFVYDPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TREKFPEKIPFRLTRMLTNAMEVTGLDGNYRITCHTVMEVLREHKDSVMAVLEAFVYDPL
             1960      1970      1980      1990      2000      2010

       2430      2440      2450      2460      2470      2480      
pF1KB1 LNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILDGVELGEPAHKKTGTTVPESIHSFIGDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILDGVELGEPAHKKTGTTVPESIHSFIGDG
             2020      2030      2040      2050      2060      2070

       2490      2500      2510      2520      2530      2540      
pF1KB1 LVKPEALNKKAIQIINRVRDKLTGRDFSHDDTLDVPTQVELLIKQATSHENLCQCYIGWC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVKPEALNKKAIQIINRVRDKLTGRDFSHDDTLDVPTQVELLIKQATSHENLCQCYIGWC
             2080      2090      2100      2110      2120      2130

          
pF1KB1 PFW
       :::
XP_016 PFW
          

>>XP_011539468 (OMIM: 601231,616638) PREDICTED: serine/t  (1590 aa)
 initn: 10385 init1: 10385 opt: 10385  Z-score: 11297.9  bits: 2104.0 E(85289):    0
Smith-Waterman score: 10385; 99.9% identity (99.9% similar) in 1588 aa overlap (1-1588:1-1588)

               10        20        30        40        50        60
pF1KB1 MLGTGPAAATTAATTSSNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MLGTGPAAATTAATTSSNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEES
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB1 TRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSNDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSNDP
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB1 VVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB1 TFFFQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLILTTQREPKEMQKPQWYRHTFEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TFFFQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLILTTQREPKEMQKPQWYRHTFEE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB1 AEKGFDETLAKEKGMNRDDRIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKYC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AEKGFDETLAKEKGMNRDDRIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKYC
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB1 KDLMGFGTKPRHITPFTSFQAVQPQQSNALVGLLGYSSHQGLMGFGTSPSPAKSTLVESR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDLMGFGTKPRHITPFTSFQAVQPQQSNALVGLLGYSSHQGLMGFGTSPSPAKSTLVESR
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB1 CCRDLMEEKFDQVCQWVLKCRNSKNSLIQMTILNLLPRLAAFRPSAFTDTQYLQDTMNHV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CCRDLMEEKFDQVCQWVLKCRNSKNSLIQMTILNLLPRLAAFRPSAFTDTQYLQDTMNHV
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB1 LSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKAMQVDA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKAMQVDA
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB1 TVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLL
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB1 KMLSLVLMHKPLRHPGMPKGLAHQLASPGLTTLPEASDVGSITLALRTLGSFEFEGHSLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KMLSLVLMHKPLRHPGMPKGLAHQLASPGLTTLPEASDVGSITLALRTLGSFEFEGHSLT
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB1 QFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLL
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB1 VVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSS
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB1 MNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALI
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB1 LKLKDPDPDPNPGVINNVLATIGELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKLKDPDPDPNPGVINNVLATIGELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVA
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB1 LWTLGQLVASTGYVVELYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHK
       :::::::::::::::: :::::::::::::::::::::::::::::::::::::::::::
XP_011 LWTLGQLVASTGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHK
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KB1 VNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFR
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KB1 DQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLV
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KB1 SFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLR
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KB1 VFMHDNSPGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPEAPLPSRKAALETVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VFMHDNSPGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPEAPLPSRKAALETVD
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KB1 RLTESLDFTDYASRIIHPIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLTESLDFTDYASRIIHPIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLV
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KB1 RHRINHQRYDVLICRIVKGYTLADEEEDPLIYQHRMLRSGQGDALASGPVETGPMKKLHV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RHRINHQRYDVLICRIVKGYTLADEEEDPLIYQHRMLRSGQGDALASGPVETGPMKKLHV
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KB1 STINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 STINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNA
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KB1 AFVSCWSELNEDQQDELIRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AFVSCWSELNEDQQDELIRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGI
             1330      1340      1350      1360      1370      1380

             1390      1400      1410      1420      1430      1440
pF1KB1 VLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHF
             1390      1400      1410      1420      1430      1440

             1450      1460      1470      1480      1490      1500
pF1KB1 GELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEK
             1450      1460      1470      1480      1490      1500

             1510      1520      1530      1540      1550      1560
pF1KB1 WTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLA
             1510      1520      1530      1540      1550      1560

             1570      1580      1590      1600      1610      1620
pF1KB1 QQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEEVIQYKLVPERREIIRQIWW
       ::::::::::::::::::::::::::::                                
XP_011 QQCIDKARDLLDAELTAMAGESYSRAYGIP                              
             1570      1580      1590                              

>>XP_016856391 (OMIM: 601231,616638) PREDICTED: serine/t  (1424 aa)
 initn: 9338 init1: 9208 opt: 9208  Z-score: 10017.0  bits: 1866.8 E(85289):    0
Smith-Waterman score: 9208; 99.7% identity (99.9% similar) in 1420 aa overlap (1-1420:1-1420)

               10        20        30        40        50        60
pF1KB1 MLGTGPAAATTAATTSSNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MLGTGPAAATTAATTSSNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEES
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB1 TRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSNDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSNDP
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB1 VVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB1 TFFFQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLILTTQREPKEMQKPQWYRHTFEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TFFFQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLILTTQREPKEMQKPQWYRHTFEE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB1 AEKGFDETLAKEKGMNRDDRIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKYC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AEKGFDETLAKEKGMNRDDRIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKYC
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB1 KDLMGFGTKPRHITPFTSFQAVQPQQSNALVGLLGYSSHQGLMGFGTSPSPAKSTLVESR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KDLMGFGTKPRHITPFTSFQAVQPQQSNALVGLLGYSSHQGLMGFGTSPSPAKSTLVESR
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB1 CCRDLMEEKFDQVCQWVLKCRNSKNSLIQMTILNLLPRLAAFRPSAFTDTQYLQDTMNHV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CCRDLMEEKFDQVCQWVLKCRNSKNSLIQMTILNLLPRLAAFRPSAFTDTQYLQDTMNHV
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB1 LSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKAMQVDA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKAMQVDA
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB1 TVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLL
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB1 KMLSLVLMHKPLRHPGMPKGLAHQLASPGLTTLPEASDVGSITLALRTLGSFEFEGHSLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KMLSLVLMHKPLRHPGMPKGLAHQLASPGLTTLPEASDVGSITLALRTLGSFEFEGHSLT
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB1 QFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLL
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB1 VVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSS
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB1 MNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALI
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB1 LKLKDPDPDPNPGVINNVLATIGELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKLKDPDPDPNPGVINNVLATIGELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVA
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB1 LWTLGQLVASTGYVVELYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHK
       :::::::::::::::: :::::::::::::::::::::::::::::::::::::::::::
XP_016 LWTLGQLVASTGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHK
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KB1 VNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFR
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KB1 DQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLV
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KB1 SFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLR
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KB1 VFMHDNSPGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPEAPLPSRKAALETVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VFMHDNSPGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPEAPLPSRKAALETVD
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KB1 RLTESLDFTDYASRIIHPIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLTESLDFTDYASRIIHPIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLV
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KB1 RHRINHQRYDVLICRIVKGYTLADEEEDPLIYQHRMLRSGQGDALASGPVETGPMKKLHV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RHRINHQRYDVLICRIVKGYTLADEEEDPLIYQHRMLRSGQGDALASGPVETGPMKKLHV
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KB1 STINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 STINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNA
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KB1 AFVSCWSELNEDQQDELIRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AFVSCWSELNEDQQDELIRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGI
             1330      1340      1350      1360      1370      1380

             1390      1400      1410      1420      1430      1440
pF1KB1 VLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHF
       ::::::::::::::::::::::::::::::::::::: ..                    
XP_016 VLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLIRVSLCSG                
             1390      1400      1410      1420                    

             1450      1460      1470      1480      1490      1500
pF1KB1 GELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEK

>>XP_016862132 (OMIM: 210600,601215,614564) PREDICTED: s  (2580 aa)
 initn: 928 init1: 235 opt: 625  Z-score: 666.4  bits: 137.5 E(85289): 2.2e-30
Smith-Waterman score: 749; 24.1% identity (51.2% similar) in 1192 aa overlap (1389-2548:1583-2579)

     1360      1370      1380      1390       1400       1410      
pF1KB1 NLAEFMEHSDKGPLPLRDDNGIVLLGERAAKCRAYAKA-LHYKE-LEFQKGPTPAILESL
                                     . .::..: .:..  .  .:      :  :
XP_016 MVSTVDYEDYQSVTRFLDLIPQDTLAVASFRSKAYTRAVMHFESFITEKKQNIQEHLGFL
           1560      1570      1580      1590      1600      1610  

       1420      1430      1440      1450      1460      1470      
pF1KB1 ISINNKLQQPEAAAGVLEYAMKHFGELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPEL
        ..   ...:...:::     :    :. :   .:.:   .:: . ::. .. . :.   
XP_016 QKLYAAMHEPDGVAGV-SAIRKAEPSLKEQILEHESLGLLRDATACYDRAIQLEPDQIIH
           1620       1630      1640      1650      1660      1670 

       1480      1490      1500       1510      1520      1530     
pF1KB1 MLGRMRCLEALGEWGQLHQQCCEKWTLVN-DETQAKMARMAAAAAWGLGQWDSMEEYTCM
       . : .. . .::. . .  :   . . .: .:   ..  . . ::: :.::: .:.:   
XP_016 YHGVVKSMLGLGQLSTVITQV--NGVHANRSEWTDELNTYRVEAAWKLSQWDLVENYLAA
            1680      1690        1700      1710      1720         

        1540      1550      1560         1570          1580        
pF1KB1 IPRDTHDGAFYRAVLALHQDLFSLAQQCIDKARD---LLDAE----LTAMAGE--SYSRA
             ::      . : : :.:  .. :    :   :. ::    :.: . :  ::.:.
XP_016 ------DGKSTTWSVRLGQLLLSAKKRDITAFYDSLKLVRAEQIVPLSAASFERGSYQRG
          1730      1740      1750      1760      1770      1780   

       1590      1600         1610      1620      1630      1640   
pF1KB1 YGAMVSCHMLSELEEVIQ--YKLVP-ERREIIRQIWWERLQGCQRIVEDWQKILMVRSLV
       :  .:  ::: :::. :.  ..  : .  .     :  ::.  :   .  . :: .:  .
XP_016 YEYIVRLHMLCELEHSIKPLFQHSPGDSSQEDSLNWVARLEMTQNSYRAKEPILALRRAL
          1790      1800      1810      1820      1830      1840   

               1650        1660      1670      1680      1690      
pF1KB1 VS----P-HEDM--RTWLKYASLCGKSGRLALAHKTLVLLLGVDPSRQLDHPLPTVHPQV
       .:    : ...:  . ::. : .  :.:.   :...:   :..  ::           ..
XP_016 LSLNKRPDYNEMVGECWLQSARVARKAGHHQTAYNAL---LNAGESRL---------AEL
          1850      1860      1870      1880                  1890 

       1700      1710      1720      1730      1740      1750      
pF1KB1 TYAYMKNMWKSARKIDAFQHMQHFVQTMQQQAQHAIATEDQQHKQELHKLMARCFLKLGE
            : .:.   : :. : .     ..:. ..  .  ..   . .   . .: .: .:.
XP_016 YVERAKWLWS---KGDVHQALI----VLQKGVELCFPENETPPEGKNMLIHGRAMLLVGR
            1900         1910          1920      1930      1940    

       1760      1770      1780      1790      1800       1810     
pF1KB1 WQLNLQGINESTIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEAVLHY-KHQNQARDEKK
       .. .  ... ..: :  .  .:   .          :   .:  . .: : . .. :.: 
XP_016 FMEETANFESNAIMKKYKDVTACLPE----------WEDGHFYLAKYYDKLMPMVTDNK-
         1950      1960      1970                1980      1990    

        1820      1830      1840      1850      1860      1870     
pF1KB1 KLRHASGANITNATTAATTAATATTTASTEGSNSESEAESTENSPTPSPLQKKVTEDLSK
                                                        ..:.   :: .
XP_016 -------------------------------------------------MEKQ--GDLIR
                                                             2000  

        1880      1890      1900        1910      1920      1930   
pF1KB1 TLLMYTVPAVQGFFRSISLSRGNNL--QDTLRVLTLWFDYGHWPDVNEALVEGVKAIQID
        ....       : ::  :. ::..  :.  :.::::.:::            .:: .  
XP_016 YIVLH-------FGRS--LQYGNQFIYQSMPRMLTLWLDYG------------TKAYE--
                  2010        2020      2030                       

          1940      1950      1960      1970      1980      1990   
pF1KB1 TWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVASKSTTTARHNAANK
        : ..     .: :       :.  :. .:.:. .     .   .:  .  ::     ..
XP_016 -WEKA-----GRSD-------RV--QMRNDLGKINKVITEHTNYLAPYQFLTA----FSQ
     2040                    2050      2060      2070          2080

          2000      2010      2020      2030      2040      2050   
pF1KB1 ILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFGERNVKGMFEVLEP
       ... .: ::.  :  ..:     . .:   . ::   .  .:.  .  : :.   :.:. 
XP_016 LISRIC-HSHDEVFVVLMEIIAKVFLAYPQQAMWM--MTAVSKSSYPMR-VNRCKEILN-
              2090      2100      2110        2120       2130      

          2060      2070      2080      2090      2100      2110   
pF1KB1 LHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISK
        .:.  .  ..:..   . .   : .   : : : . .:. . :.    .  : :. ..:
XP_016 -KAIHMK--KSLEKFVGDATRLTDKL--LELCNKPV-DGSSSTLS----MSTH-FKMLKK
         2140        2150        2160       2170           2180    

          2120      2130        2140      2150          2160       
pF1KB1 QLPQLTSLELQYVSPKLLMCRDLE--LAVPGTYDPNQPI----IRIQSIAPSLQVITSKQ
        . . :  :.  .  . .:   :   :.. ...  ..:.      : ..   .....: :
XP_016 LVEEATFSEI-LIPLQSVMIPTLPSILGTHANHASHEPFPGHWAYIAGFDDMVEILASLQ
         2190       2200      2210      2220      2230      2240   

      2170      2180      2190      2200      2210      2220       
pF1KB1 RPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAV
       .:.:..: ::.:. .... : ..:::.: :.:.. .:.:  : .:  : :..: :. :::
XP_016 KPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAV
          2250      2260      2270      2280      2290      2300   

      2230      2240      2250       2260      2270      2280      
pF1KB1 IPLSTNSGLIGWVPHCDTLHALI-RDYREKKKILLNIEHRIMLRMAPDYDHLTLMQKVEV
       :::. . :.: :: .   :. .. . :.::   . . : :    : :    :.  .:..:
XP_016 IPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKELRQC--MLPKSAALS--EKLKV
          2310      2320      2330      2340        2350           

       2290      2300      2310      2320      2330      2340      
pF1KB1 FEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLML
       :.. .       . . .    :.   :.. :. : :: ::::::::::::::::  :...
XP_016 FREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILF
    2360      2370      2380      2390      2400      2410         

       2350      2360      2370      2380      2390      2400      
pF1KB1 DRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRITCHTVMEV
       : :.:. .:.::.  :. . : :  :: .:::::. ..:.:   : .: .: .:...:..
XP_016 DSLTGECVHVDFNCLFNKGETFE-VPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRL
    2420      2430      2440       2450      2460      2470        

       2410      2420      2430      2440      2450      2460      
pF1KB1 LREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILDGVELGEP
       .:.... .:.::..:..:::..:   .  .::....                       :
XP_016 MRDQREPLMSVLKTFLHDPLVEW---SKPVKGHSKA-----------------------P
     2480      2490      2500         2510                         

       2470      2480      2490      2500      2510      2520      
pF1KB1 AHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDDTLDVPTQVE
        .. :: .: :. .. . :         .. .: . ..:...::  .:      .  .:.
XP_016 LNE-TGEVVNEKAKTHVLD--------IEQRLQGVIKTRNRVTGLPLS------IEGHVH
            2520      2530              2540      2550             

       2530      2540         
pF1KB1 LLIKQATSHENLCQCYIGWCPFW
        ::..::... ::: :.:: :. 
XP_016 YLIQEATDENLLCQMYLGWTPYM
      2560      2570      2580

>>XP_011511227 (OMIM: 210600,601215,614564) PREDICTED: s  (2582 aa)
 initn: 928 init1: 235 opt: 625  Z-score: 666.4  bits: 137.5 E(85289): 2.2e-30
Smith-Waterman score: 749; 24.1% identity (51.2% similar) in 1192 aa overlap (1389-2548:1585-2581)

     1360      1370      1380      1390       1400       1410      
pF1KB1 NLAEFMEHSDKGPLPLRDDNGIVLLGERAAKCRAYAKA-LHYKE-LEFQKGPTPAILESL
                                     . .::..: .:..  .  .:      :  :
XP_011 MVSTVDYEDYQSVTRFLDLIPQDTLAVASFRSKAYTRAVMHFESFITEKKQNIQEHLGFL
         1560      1570      1580      1590      1600      1610    

       1420      1430      1440      1450      1460      1470      
pF1KB1 ISINNKLQQPEAAAGVLEYAMKHFGELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPEL
        ..   ...:...:::     :    :. :   .:.:   .:: . ::. .. . :.   
XP_011 QKLYAAMHEPDGVAGV-SAIRKAEPSLKEQILEHESLGLLRDATACYDRAIQLEPDQIIH
         1620      1630       1640      1650      1660      1670   

       1480      1490      1500       1510      1520      1530     
pF1KB1 MLGRMRCLEALGEWGQLHQQCCEKWTLVN-DETQAKMARMAAAAAWGLGQWDSMEEYTCM
       . : .. . .::. . .  :   . . .: .:   ..  . . ::: :.::: .:.:   
XP_011 YHGVVKSMLGLGQLSTVITQV--NGVHANRSEWTDELNTYRVEAAWKLSQWDLVENYLAA
          1680      1690        1700      1710      1720      1730 

        1540      1550      1560         1570          1580        
pF1KB1 IPRDTHDGAFYRAVLALHQDLFSLAQQCIDKARD---LLDAE----LTAMAGE--SYSRA
             ::      . : : :.:  .. :    :   :. ::    :.: . :  ::.:.
XP_011 ------DGKSTTWSVRLGQLLLSAKKRDITAFYDSLKLVRAEQIVPLSAASFERGSYQRG
                  1740      1750      1760      1770      1780     

       1590      1600         1610      1620      1630      1640   
pF1KB1 YGAMVSCHMLSELEEVIQ--YKLVP-ERREIIRQIWWERLQGCQRIVEDWQKILMVRSLV
       :  .:  ::: :::. :.  ..  : .  .     :  ::.  :   .  . :: .:  .
XP_011 YEYIVRLHMLCELEHSIKPLFQHSPGDSSQEDSLNWVARLEMTQNSYRAKEPILALRRAL
        1790      1800      1810      1820      1830      1840     

               1650        1660      1670      1680      1690      
pF1KB1 VS----P-HEDM--RTWLKYASLCGKSGRLALAHKTLVLLLGVDPSRQLDHPLPTVHPQV
       .:    : ...:  . ::. : .  :.:.   :...:   :..  ::           ..
XP_011 LSLNKRPDYNEMVGECWLQSARVARKAGHHQTAYNAL---LNAGESRL---------AEL
        1850      1860      1870      1880         1890            

       1700      1710      1720      1730      1740      1750      
pF1KB1 TYAYMKNMWKSARKIDAFQHMQHFVQTMQQQAQHAIATEDQQHKQELHKLMARCFLKLGE
            : .:.   : :. : .     ..:. ..  .  ..   . .   . .: .: .:.
XP_011 YVERAKWLWS---KGDVHQALI----VLQKGVELCFPENETPPEGKNMLIHGRAMLLVGR
          1900         1910          1920      1930      1940      

       1760      1770      1780      1790      1800       1810     
pF1KB1 WQLNLQGINESTIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEAVLHY-KHQNQARDEKK
       .. .  ... ..: :  .  .:   .          :   .:  . .: : . .. :.: 
XP_011 FMEETANFESNAIMKKYKDVTACLPE----------WEDGHFYLAKYYDKLMPMVTDNK-
       1950      1960      1970                1980      1990      

        1820      1830      1840      1850      1860      1870     
pF1KB1 KLRHASGANITNATTAATTAATATTTASTEGSNSESEAESTENSPTPSPLQKKVTEDLSK
                                                        ..:.   :: .
XP_011 -------------------------------------------------MEKQ--GDLIR
                                                           2000    

        1880      1890      1900        1910      1920      1930   
pF1KB1 TLLMYTVPAVQGFFRSISLSRGNNL--QDTLRVLTLWFDYGHWPDVNEALVEGVKAIQID
        ....       : ::  :. ::..  :.  :.::::.:::            .:: .  
XP_011 YIVLH-------FGRS--LQYGNQFIYQSMPRMLTLWLDYG------------TKAYE--
                2010        2020      2030                  2040   

          1940      1950      1960      1970      1980      1990   
pF1KB1 TWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVASKSTTTARHNAANK
        : ..     .: :       :.  :. .:.:. .     .   .:  .  ::     ..
XP_011 -WEKA-----GRSD-------RV--QMRNDLGKINKVITEHTNYLAPYQFLTA----FSQ
                         2050        2060      2070          2080  

          2000      2010      2020      2030      2040      2050   
pF1KB1 ILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFGERNVKGMFEVLEP
       ... .: ::.  :  ..:     . .:   . ::   .  .:.  .  : :.   :.:. 
XP_011 LISRIC-HSHDEVFVVLMEIIAKVFLAYPQQAMWM--MTAVSKSSYPMR-VNRCKEILN-
            2090      2100      2110        2120       2130        

          2060      2070      2080      2090      2100      2110   
pF1KB1 LHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISK
        .:.  .  ..:..   . .   : .   : : : . .:. . :.    .  : :. ..:
XP_011 -KAIHMK--KSLEKFVGDATRLTDKL--LELCNKPV-DGSSSTLS----MSTH-FKMLKK
       2140        2150      2160         2170          2180       

          2120      2130        2140      2150          2160       
pF1KB1 QLPQLTSLELQYVSPKLLMCRDLE--LAVPGTYDPNQPI----IRIQSIAPSLQVITSKQ
        . . :  :.  .  . .:   :   :.. ...  ..:.      : ..   .....: :
XP_011 LVEEATFSEI-LIPLQSVMIPTLPSILGTHANHASHEPFPGHWAYIAGFDDMVEILASLQ
       2190       2200      2210      2220      2230      2240     

      2170      2180      2190      2200      2210      2220       
pF1KB1 RPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAV
       .:.:..: ::.:. .... : ..:::.: :.:.. .:.:  : .:  : :..: :. :::
XP_011 KPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAV
        2250      2260      2270      2280      2290      2300     

      2230      2240      2250       2260      2270      2280      
pF1KB1 IPLSTNSGLIGWVPHCDTLHALI-RDYREKKKILLNIEHRIMLRMAPDYDHLTLMQKVEV
       :::. . :.: :: .   :. .. . :.::   . . : :    : :    :.  .:..:
XP_011 IPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKELRQC--MLPKSAALS--EKLKV
        2310      2320      2330      2340        2350        2360 

       2290      2300      2310      2320      2330      2340      
pF1KB1 FEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLML
       :.. .       . . .    :.   :.. :. : :: ::::::::::::::::  :...
XP_011 FREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILF
            2370      2380      2390      2400      2410      2420 

       2350      2360      2370      2380      2390      2400      
pF1KB1 DRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRITCHTVMEV
       : :.:. .:.::.  :. . : :  :: .:::::. ..:.:   : .: .: .:...:..
XP_011 DSLTGECVHVDFNCLFNKGETFE-VPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRL
            2430      2440       2450      2460      2470      2480

       2410      2420      2430      2440      2450      2460      
pF1KB1 LREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILDGVELGEP
       .:.... .:.::..:..:::..:   .  .::....                       :
XP_011 MRDQREPLMSVLKTFLHDPLVEW---SKPVKGHSKA-----------------------P
             2490      2500         2510                           

       2470      2480      2490      2500      2510      2520      
pF1KB1 AHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDDTLDVPTQVE
        .. :: .: :. .. . :         .. .: . ..:...::  .:      .  .:.
XP_011 LNE-TGEVVNEKAKTHVLD--------IEQRLQGVIKTRNRVTGLPLS------IEGHVH
          2520      2530              2540      2550               

       2530      2540         
pF1KB1 LLIKQATSHENLCQCYIGWCPFW
        ::..::... ::: :.:: :. 
XP_011 YLIQEATDENLLCQMYLGWTPYM
    2560      2570      2580  

>>NP_001175 (OMIM: 210600,601215,614564) serine/threonin  (2644 aa)
 initn: 928 init1: 235 opt: 625  Z-score: 666.2  bits: 137.5 E(85289): 2.3e-30
Smith-Waterman score: 749; 24.1% identity (51.2% similar) in 1192 aa overlap (1389-2548:1647-2643)

     1360      1370      1380      1390       1400       1410      
pF1KB1 NLAEFMEHSDKGPLPLRDDNGIVLLGERAAKCRAYAKA-LHYKE-LEFQKGPTPAILESL
                                     . .::..: .:..  .  .:      :  :
NP_001 MVSTVDYEDYQSVTRFLDLIPQDTLAVASFRSKAYTRAVMHFESFITEKKQNIQEHLGFL
       1620      1630      1640      1650      1660      1670      

       1420      1430      1440      1450      1460      1470      
pF1KB1 ISINNKLQQPEAAAGVLEYAMKHFGELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPEL
        ..   ...:...:::     :    :. :   .:.:   .:: . ::. .. . :.   
NP_001 QKLYAAMHEPDGVAGV-SAIRKAEPSLKEQILEHESLGLLRDATACYDRAIQLEPDQIIH
       1680      1690       1700      1710      1720      1730     

       1480      1490      1500       1510      1520      1530     
pF1KB1 MLGRMRCLEALGEWGQLHQQCCEKWTLVN-DETQAKMARMAAAAAWGLGQWDSMEEYTCM
       . : .. . .::. . .  :   . . .: .:   ..  . . ::: :.::: .:.:   
NP_001 YHGVVKSMLGLGQLSTVITQV--NGVHANRSEWTDELNTYRVEAAWKLSQWDLVENYLAA
        1740      1750        1760      1770      1780      1790   

        1540      1550      1560         1570          1580        
pF1KB1 IPRDTHDGAFYRAVLALHQDLFSLAQQCIDKARD---LLDAE----LTAMAGE--SYSRA
             ::      . : : :.:  .. :    :   :. ::    :.: . :  ::.:.
NP_001 ------DGKSTTWSVRLGQLLLSAKKRDITAFYDSLKLVRAEQIVPLSAASFERGSYQRG
                1800      1810      1820      1830      1840       

       1590      1600         1610      1620      1630      1640   
pF1KB1 YGAMVSCHMLSELEEVIQ--YKLVP-ERREIIRQIWWERLQGCQRIVEDWQKILMVRSLV
       :  .:  ::: :::. :.  ..  : .  .     :  ::.  :   .  . :: .:  .
NP_001 YEYIVRLHMLCELEHSIKPLFQHSPGDSSQEDSLNWVARLEMTQNSYRAKEPILALRRAL
      1850      1860      1870      1880      1890      1900       

               1650        1660      1670      1680      1690      
pF1KB1 VS----P-HEDM--RTWLKYASLCGKSGRLALAHKTLVLLLGVDPSRQLDHPLPTVHPQV
       .:    : ...:  . ::. : .  :.:.   :...:   :..  ::           ..
NP_001 LSLNKRPDYNEMVGECWLQSARVARKAGHHQTAYNAL---LNAGESRL---------AEL
      1910      1920      1930      1940         1950              

       1700      1710      1720      1730      1740      1750      
pF1KB1 TYAYMKNMWKSARKIDAFQHMQHFVQTMQQQAQHAIATEDQQHKQELHKLMARCFLKLGE
            : .:.   : :. : .     ..:. ..  .  ..   . .   . .: .: .:.
NP_001 YVERAKWLWS---KGDVHQALI----VLQKGVELCFPENETPPEGKNMLIHGRAMLLVGR
        1960         1970          1980      1990      2000        

       1760      1770      1780      1790      1800       1810     
pF1KB1 WQLNLQGINESTIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEAVLHY-KHQNQARDEKK
       .. .  ... ..: :  .  .:   .          :   .:  . .: : . .. :.: 
NP_001 FMEETANFESNAIMKKYKDVTACLPE----------WEDGHFYLAKYYDKLMPMVTDNK-
     2010      2020      2030                2040      2050        

        1820      1830      1840      1850      1860      1870     
pF1KB1 KLRHASGANITNATTAATTAATATTTASTEGSNSESEAESTENSPTPSPLQKKVTEDLSK
                                                        ..:.   :: .
NP_001 -------------------------------------------------MEKQ--GDLIR
                                                       2060        

        1880      1890      1900        1910      1920      1930   
pF1KB1 TLLMYTVPAVQGFFRSISLSRGNNL--QDTLRVLTLWFDYGHWPDVNEALVEGVKAIQID
        ....       : ::  :. ::..  :.  :.::::.:::            .:: .  
NP_001 YIVLH-------FGRS--LQYGNQFIYQSMPRMLTLWLDYG------------TKAYE--
       2070               2080      2090                  2100     

          1940      1950      1960      1970      1980      1990   
pF1KB1 TWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVASKSTTTARHNAANK
        : ..     .: :       :.  :. .:.:. .     .   .:  .  ::     ..
NP_001 -WEKA-----GRSD-------RV--QMRNDLGKINKVITEHTNYLAPYQFLTA----FSQ
                2110               2120      2130      2140        

          2000      2010      2020      2030      2040      2050   
pF1KB1 ILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFGERNVKGMFEVLEP
       ... .: ::.  :  ..:     . .:   . ::   .  .:.  .  : :.   :.:. 
NP_001 LISRIC-HSHDEVFVVLMEIIAKVFLAYPQQAMWM--MTAVSKSSYPMR-VNRCKEILN-
         2150       2160      2170        2180      2190           

          2060      2070      2080      2090      2100      2110   
pF1KB1 LHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISK
        .:.  .  ..:..   . .   : .   : : : . .:. . :.    .  : :. ..:
NP_001 -KAIHMK--KSLEKFVGDATRLTDKL--LELCNKPV-DGSSSTLS----MSTH-FKMLKK
     2200        2210      2220        2230           2240         

          2120      2130        2140      2150          2160       
pF1KB1 QLPQLTSLELQYVSPKLLMCRDLE--LAVPGTYDPNQPI----IRIQSIAPSLQVITSKQ
        . . :  :.  .  . .:   :   :.. ...  ..:.      : ..   .....: :
NP_001 LVEEATFSEI-LIPLQSVMIPTLPSILGTHANHASHEPFPGHWAYIAGFDDMVEILASLQ
     2250       2260      2270      2280      2290      2300       

      2170      2180      2190      2200      2210      2220       
pF1KB1 RPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAV
       .:.:..: ::.:. .... : ..:::.: :.:.. .:.:  : .:  : :..: :. :::
NP_001 KPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAV
      2310      2320      2330      2340      2350      2360       

      2230      2240      2250       2260      2270      2280      
pF1KB1 IPLSTNSGLIGWVPHCDTLHALI-RDYREKKKILLNIEHRIMLRMAPDYDHLTLMQKVEV
       :::. . :.: :: .   :. .. . :.::   . . : :    : :    :.  .:..:
NP_001 IPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKELRQC--MLPKSAALS--EKLKV
      2370      2380      2390      2400        2410        2420   

       2290      2300      2310      2320      2330      2340      
pF1KB1 FEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLML
       :.. .       . . .    :.   :.. :. : :: ::::::::::::::::  :...
NP_001 FREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILF
          2430      2440      2450      2460      2470      2480   

       2350      2360      2370      2380      2390      2400      
pF1KB1 DRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRITCHTVMEV
       : :.:. .:.::.  :. . : :  :: .:::::. ..:.:   : .: .: .:...:..
NP_001 DSLTGECVHVDFNCLFNKGETFE-VPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRL
          2490      2500       2510      2520      2530      2540  

       2410      2420      2430      2440      2450      2460      
pF1KB1 LREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILDGVELGEP
       .:.... .:.::..:..:::..:   .  .::....                       :
NP_001 MRDQREPLMSVLKTFLHDPLVEW---SKPVKGHSKA-----------------------P
           2550      2560         2570                             

       2470      2480      2490      2500      2510      2520      
pF1KB1 AHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDDTLDVPTQVE
        .. :: .: :. .. . :         .. .: . ..:...::  .:      .  .:.
NP_001 LNE-TGEVVNEKAKTHVLD--------IEQRLQGVIKTRNRVTGLPLS------IEGHVH
        2580      2590              2600      2610            2620 

       2530      2540         
pF1KB1 LLIKQATSHENLCQCYIGWCPFW
        ::..::... ::: :.:: :. 
NP_001 YLIQEATDENLLCQMYLGWTPYM
            2630      2640    

>>XP_011511226 (OMIM: 210600,601215,614564) PREDICTED: s  (2646 aa)
 initn: 928 init1: 235 opt: 625  Z-score: 666.2  bits: 137.5 E(85289): 2.3e-30
Smith-Waterman score: 749; 24.1% identity (51.2% similar) in 1192 aa overlap (1389-2548:1649-2645)

     1360      1370      1380      1390       1400       1410      
pF1KB1 NLAEFMEHSDKGPLPLRDDNGIVLLGERAAKCRAYAKA-LHYKE-LEFQKGPTPAILESL
                                     . .::..: .:..  .  .:      :  :
XP_011 MVSTVDYEDYQSVTRFLDLIPQDTLAVASFRSKAYTRAVMHFESFITEKKQNIQEHLGFL
     1620      1630      1640      1650      1660      1670        

       1420      1430      1440      1450      1460      1470      
pF1KB1 ISINNKLQQPEAAAGVLEYAMKHFGELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPEL
        ..   ...:...:::     :    :. :   .:.:   .:: . ::. .. . :.   
XP_011 QKLYAAMHEPDGVAGV-SAIRKAEPSLKEQILEHESLGLLRDATACYDRAIQLEPDQIIH
     1680      1690       1700      1710      1720      1730       

       1480      1490      1500       1510      1520      1530     
pF1KB1 MLGRMRCLEALGEWGQLHQQCCEKWTLVN-DETQAKMARMAAAAAWGLGQWDSMEEYTCM
       . : .. . .::. . .  :   . . .: .:   ..  . . ::: :.::: .:.:   
XP_011 YHGVVKSMLGLGQLSTVITQV--NGVHANRSEWTDELNTYRVEAAWKLSQWDLVENYLAA
      1740      1750        1760      1770      1780      1790     

        1540      1550      1560         1570          1580        
pF1KB1 IPRDTHDGAFYRAVLALHQDLFSLAQQCIDKARD---LLDAE----LTAMAGE--SYSRA
             ::      . : : :.:  .. :    :   :. ::    :.: . :  ::.:.
XP_011 ------DGKSTTWSVRLGQLLLSAKKRDITAFYDSLKLVRAEQIVPLSAASFERGSYQRG
              1800      1810      1820      1830      1840         

       1590      1600         1610      1620      1630      1640   
pF1KB1 YGAMVSCHMLSELEEVIQ--YKLVP-ERREIIRQIWWERLQGCQRIVEDWQKILMVRSLV
       :  .:  ::: :::. :.  ..  : .  .     :  ::.  :   .  . :: .:  .
XP_011 YEYIVRLHMLCELEHSIKPLFQHSPGDSSQEDSLNWVARLEMTQNSYRAKEPILALRRAL
    1850      1860      1870      1880      1890      1900         

               1650        1660      1670      1680      1690      
pF1KB1 VS----P-HEDM--RTWLKYASLCGKSGRLALAHKTLVLLLGVDPSRQLDHPLPTVHPQV
       .:    : ...:  . ::. : .  :.:.   :...:   :..  ::           ..
XP_011 LSLNKRPDYNEMVGECWLQSARVARKAGHHQTAYNAL---LNAGESRL---------AEL
    1910      1920      1930      1940         1950                

       1700      1710      1720      1730      1740      1750      
pF1KB1 TYAYMKNMWKSARKIDAFQHMQHFVQTMQQQAQHAIATEDQQHKQELHKLMARCFLKLGE
            : .:.   : :. : .     ..:. ..  .  ..   . .   . .: .: .:.
XP_011 YVERAKWLWS---KGDVHQALI----VLQKGVELCFPENETPPEGKNMLIHGRAMLLVGR
      1960         1970          1980      1990      2000      2010

       1760      1770      1780      1790      1800       1810     
pF1KB1 WQLNLQGINESTIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEAVLHY-KHQNQARDEKK
       .. .  ... ..: :  .  .:   .          :   .:  . .: : . .. :.: 
XP_011 FMEETANFESNAIMKKYKDVTACLPE----------WEDGHFYLAKYYDKLMPMVTDNK-
             2020      2030                2040      2050          

        1820      1830      1840      1850      1860      1870     
pF1KB1 KLRHASGANITNATTAATTAATATTTASTEGSNSESEAESTENSPTPSPLQKKVTEDLSK
                                                        ..:.   :: .
XP_011 -------------------------------------------------MEKQ--GDLIR
                                                     2060          

        1880      1890      1900        1910      1920      1930   
pF1KB1 TLLMYTVPAVQGFFRSISLSRGNNL--QDTLRVLTLWFDYGHWPDVNEALVEGVKAIQID
        ....       : ::  :. ::..  :.  :.::::.:::            .:: .  
XP_011 YIVLH-------FGRS--LQYGNQFIYQSMPRMLTLWLDYG------------TKAYE--
     2070               2080      2090      2100                   

          1940      1950      1960      1970      1980      1990   
pF1KB1 TWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVASKSTTTARHNAANK
        : ..     .: :       :.  :. .:.:. .     .   .:  .  ::     ..
XP_011 -WEKA-----GRSD-------RV--QMRNDLGKINKVITEHTNYLAPYQFLTA----FSQ
              2110               2120      2130      2140          

          2000      2010      2020      2030      2040      2050   
pF1KB1 ILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFGERNVKGMFEVLEP
       ... .: ::.  :  ..:     . .:   . ::   .  .:.  .  : :.   :.:. 
XP_011 LISRIC-HSHDEVFVVLMEIIAKVFLAYPQQAMWM--MTAVSKSSYPMR-VNRCKEILN-
       2150       2160      2170      2180        2190       2200  

          2060      2070      2080      2090      2100      2110   
pF1KB1 LHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISK
        .:.  .  ..:..   . .   : .   : : : . .:. . :.    .  : :. ..:
XP_011 -KAIHMK--KSLEKFVGDATRLTDKL--LELCNKPV-DGSSSTLS----MSTH-FKMLKK
               2210      2220        2230       2240           2250

          2120      2130        2140      2150          2160       
pF1KB1 QLPQLTSLELQYVSPKLLMCRDLE--LAVPGTYDPNQPI----IRIQSIAPSLQVITSKQ
        . . :  :.  .  . .:   :   :.. ...  ..:.      : ..   .....: :
XP_011 LVEEATFSEI-LIPLQSVMIPTLPSILGTHANHASHEPFPGHWAYIAGFDDMVEILASLQ
             2260       2270      2280      2290      2300         

      2170      2180      2190      2200      2210      2220       
pF1KB1 RPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAV
       .:.:..: ::.:. .... : ..:::.: :.:.. .:.:  : .:  : :..: :. :::
XP_011 KPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAV
    2310      2320      2330      2340      2350      2360         

      2230      2240      2250       2260      2270      2280      
pF1KB1 IPLSTNSGLIGWVPHCDTLHALI-RDYREKKKILLNIEHRIMLRMAPDYDHLTLMQKVEV
       :::. . :.: :: .   :. .. . :.::   . . : :    : :    :.  .:..:
XP_011 IPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKELRQC--MLPKSAALS--EKLKV
    2370      2380      2390      2400      2410        2420       

       2290      2300      2310      2320      2330      2340      
pF1KB1 FEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLML
       :.. .       . . .    :.   :.. :. : :: ::::::::::::::::  :...
XP_011 FREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILF
        2430      2440      2450      2460      2470      2480     

       2350      2360      2370      2380      2390      2400      
pF1KB1 DRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRITCHTVMEV
       : :.:. .:.::.  :. . : :  :: .:::::. ..:.:   : .: .: .:...:..
XP_011 DSLTGECVHVDFNCLFNKGETFE-VPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRL
        2490      2500       2510      2520      2530      2540    

       2410      2420      2430      2440      2450      2460      
pF1KB1 LREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILDGVELGEP
       .:.... .:.::..:..:::..:   .  .::....                       :
XP_011 MRDQREPLMSVLKTFLHDPLVEW---SKPVKGHSKA-----------------------P
         2550      2560         2570                               

       2470      2480      2490      2500      2510      2520      
pF1KB1 AHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDDTLDVPTQVE
        .. :: .: :. .. . :         .. .: . ..:...::  .:      .  .:.
XP_011 LNE-TGEVVNEKAKTHVLD--------IEQRLQGVIKTRNRVTGLPLS------IEGHVH
     2580       2590              2600      2610            2620   

       2530      2540         
pF1KB1 LLIKQATSHENLCQCYIGWCPFW
        ::..::... ::: :.:: :. 
XP_011 YLIQEATDENLLCQMYLGWTPYM
          2630      2640      




2549 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 11:47:43 2016 done: Thu Nov  3 11:47:46 2016
 Total Scan time: 16.620 Total Display time:  1.540

Function used was FASTA [36.3.4 Apr, 2011]
Inquiries or Suggestions ?
Send a message to flexiclone AT kazusagt.com