Result of FASTA (omim) for pF1KA0720
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KA0720, 1062 aa
  1>>>pF1KA0720 1062 - 1062 aa - 1062 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 11.6289+/-0.00039; mu= -7.1019+/- 0.024
 mean_var=348.1343+/-72.565, 0's: 0 Z-trim(123.3): 152  B-trim: 412 in 1/54
 Lambda= 0.068739
 statistics sampled from 42711 (42866) to 42711 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.791), E-opt: 0.2 (0.503), width:  16
 Scan time: 16.920

The best scores are:                                      opt bits E(85289)
NP_001036128 (OMIM: 611067,611101,615376) pleckstr (1062) 7155 724.2 9.8e-208
NP_941374 (OMIM: 611067,611101,615376) pleckstrin  (1083) 7148 723.5 1.6e-207
NP_001252521 (OMIM: 611067,611101,615376) pleckstr (1085) 7140 722.7 2.8e-207
NP_001252522 (OMIM: 611067,611101,615376) pleckstr (1075) 6969 705.7 3.5e-202
NP_001036130 (OMIM: 611067,611101,615376) pleckstr (1006) 6734 682.4 3.5e-195
NP_001036129 (OMIM: 611067,611101,615376) pleckstr (1006) 6734 682.4 3.5e-195
NP_065682 (OMIM: 611067,611101,615376) pleckstrin  (1006) 6734 682.4 3.5e-195
NP_001252523 (OMIM: 611067,611101,615376) pleckstr ( 930) 6091 618.6 5.1e-176
NP_001138329 (OMIM: 611743) pleckstrin homology do ( 758) 1391 152.4 8.8e-36
XP_011519269 (OMIM: 611743) PREDICTED: pleckstrin  ( 768) 1391 152.4 8.9e-36
XP_016875044 (OMIM: 611743) PREDICTED: pleckstrin  ( 788) 1391 152.5 9.1e-36
NP_001138328 (OMIM: 611743) pleckstrin homology do ( 790) 1391 152.5 9.1e-36
NP_060643 (OMIM: 611743) pleckstrin homology domai ( 790) 1391 152.5 9.1e-36
XP_005253761 (OMIM: 611743) PREDICTED: pleckstrin  ( 790) 1391 152.5 9.1e-36
XP_006719048 (OMIM: 611743) PREDICTED: pleckstrin  ( 776)  782 92.1 1.4e-17
XP_016872911 (OMIM: 604763) PREDICTED: rho guanine (1401)  498 64.1 6.6e-09
XP_011541022 (OMIM: 604763) PREDICTED: rho guanine (1441)  498 64.1 6.7e-09
XP_016872910 (OMIM: 604763) PREDICTED: rho guanine (1441)  498 64.1 6.7e-09
NP_001288013 (OMIM: 604763) rho guanine nucleotide (1441)  498 64.1 6.7e-09
XP_016872909 (OMIM: 604763) PREDICTED: rho guanine (1485)  498 64.1 6.9e-09
XP_006718868 (OMIM: 604763) PREDICTED: rho guanine (1519)  498 64.1   7e-09
NP_001185594 (OMIM: 604763) rho guanine nucleotide (1525)  498 64.1   7e-09
NP_056128 (OMIM: 604763) rho guanine nucleotide ex (1544)  498 64.1 7.1e-09
XP_005259443 (OMIM: 601855) PREDICTED: rho guanine (1041)  441 58.3 2.6e-07
XP_011525770 (OMIM: 601855) PREDICTED: rho guanine ( 985)  435 57.7 3.8e-07
NP_945328 (OMIM: 601855) rho guanine nucleotide ex ( 879)  428 57.0 5.6e-07
NP_004697 (OMIM: 601855) rho guanine nucleotide ex ( 912)  428 57.0 5.7e-07
NP_945353 (OMIM: 601855) rho guanine nucleotide ex ( 927)  428 57.0 5.8e-07
XP_005259447 (OMIM: 601855) PREDICTED: rho guanine ( 981)  428 57.0 6.1e-07
XP_011508491 (OMIM: 605708) PREDICTED: rho guanine ( 945)  407 54.9 2.5e-06
XP_005245690 (OMIM: 605708) PREDICTED: rho guanine (1141)  407 55.0 2.9e-06
XP_011508489 (OMIM: 605708) PREDICTED: rho guanine (1485)  407 55.1 3.6e-06
NP_055599 (OMIM: 605708) rho guanine nucleotide ex (1522)  407 55.1 3.7e-06
XP_016858413 (OMIM: 605708) PREDICTED: rho guanine (1523)  407 55.1 3.7e-06
XP_016858412 (OMIM: 605708) PREDICTED: rho guanine (1523)  407 55.1 3.7e-06
XP_016858411 (OMIM: 605708) PREDICTED: rho guanine (1528)  407 55.1 3.7e-06
XP_006711728 (OMIM: 605708) PREDICTED: rho guanine (1538)  407 55.1 3.7e-06
XP_011508488 (OMIM: 605708) PREDICTED: rho guanine (1539)  407 55.1 3.7e-06
XP_016858410 (OMIM: 605708) PREDICTED: rho guanine (1552)  407 55.1 3.7e-06
XP_006711726 (OMIM: 605708) PREDICTED: rho guanine (1559)  407 55.1 3.7e-06
NP_937879 (OMIM: 605708) rho guanine nucleotide ex (1562)  407 55.1 3.7e-06
XP_005245686 (OMIM: 605708) PREDICTED: rho guanine (1563)  407 55.1 3.7e-06
XP_016858409 (OMIM: 605708) PREDICTED: rho guanine (1568)  407 55.1 3.7e-06
XP_006711725 (OMIM: 605708) PREDICTED: rho guanine (1568)  407 55.1 3.7e-06
XP_006711724 (OMIM: 605708) PREDICTED: rho guanine (1569)  407 55.1 3.7e-06
XP_011508487 (OMIM: 605708) PREDICTED: rho guanine (1574)  407 55.1 3.8e-06
XP_006711723 (OMIM: 605708) PREDICTED: rho guanine (1578)  407 55.1 3.8e-06
XP_006711722 (OMIM: 605708) PREDICTED: rho guanine (1579)  407 55.1 3.8e-06


>>NP_001036128 (OMIM: 611067,611101,615376) pleckstrin h  (1062 aa)
 initn: 7155 init1: 7155 opt: 7155  Z-score: 3850.5  bits: 724.2 E(85289): 9.8e-208
Smith-Waterman score: 7155; 99.9% identity (100.0% similar) in 1062 aa overlap (1-1062:1-1062)

               10        20        30        40        50        60
pF1KA0 MDDQSPAEKKGLRCQNPACMDKGRAAKVCHHADCQQLHRRGPLNLCEACDSKFHSTMHYD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDDQSPAEKKGLRCQNPACMDKGRAAKVCHHADCQQLHRRGPLNLCEACDSKFHSTMHYD
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 GHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRKSTGLKLSKKKA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRKSTGLKLSKKKA
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 RRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQ
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 SNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPPALER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPPALER
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA0 VDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSSGSTNSGDSWKN
       :::::::::::::::::::::::::::::::::::::::::::::::::::::.::::::
NP_001 VDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSSGSTNTGDSWKN
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA0 RAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYD
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA0 EDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLC
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KA0 CLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKG
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KA0 FKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKP
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KA0 HQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSR
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KA0 IDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVY
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KA0 CFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTF
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KA0 QASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEG
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KA0 EDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQS
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KA0 DETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPMAELVPRAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPMAELVPRAP
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KA0 ESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLLQLLAGAGTHGTPSAPSRSLSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLLQLLAGAGTHGTPSAPSRSLSE
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KA0 LCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDLPSGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDLPSGA
              970       980       990      1000      1010      1020

             1030      1040      1050      1060  
pF1KA0 SPRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTASEV
       ::::::::::::::::::::::::::::::::::::::::::
NP_001 SPRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTASEV
             1030      1040      1050      1060  

>>NP_941374 (OMIM: 611067,611101,615376) pleckstrin homo  (1083 aa)
 initn: 7148 init1: 7148 opt: 7148  Z-score: 3846.6  bits: 723.5 E(85289): 1.6e-207
Smith-Waterman score: 7148; 99.9% identity (100.0% similar) in 1061 aa overlap (2-1062:23-1083)

                                    10        20        30         
pF1KA0                      MDDQSPAEKKGLRCQNPACMDKGRAAKVCHHADCQQLHR
                             ::::::::::::::::::::::::::::::::::::::
NP_941 MNSVLTKHGSPPRSWLSLCSGTDDQSPAEKKGLRCQNPACMDKGRAAKVCHHADCQQLHR
               10        20        30        40        50        60

      40        50        60        70        80        90         
pF1KA0 RGPLNLCEACDSKFHSTMHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_941 RGPLNLCEACDSKFHSTMHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEE
               70        80        90       100       110       120

     100       110       120       130       140       150         
pF1KA0 SSVDGKGDRKSTGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_941 SSVDGKGDRKSTGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEV
              130       140       150       160       170       180

     160       170       180       190       200       210         
pF1KA0 LLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_941 LLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKD
              190       200       210       220       230       240

     220       230       240       250       260       270         
pF1KA0 SKSLSLPILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_941 SKSLSLPILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTP
              250       260       270       280       290       300

     280       290       300       310       320       330         
pF1KA0 SSCSLPSGSSGSTNSGDSWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLF
       ::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::
NP_941 SSCSLPSGSSGSTNTGDSWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLF
              310       320       330       340       350       360

     340       350       360       370       380       390         
pF1KA0 GLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_941 GLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWE
              370       380       390       400       410       420

     400       410       420       430       440       450         
pF1KA0 LLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_941 LLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMA
              430       440       450       460       470       480

     460       470       480       490       500       510         
pF1KA0 PVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_941 PVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYI
              490       500       510       520       530       540

     520       530       540       550       560       570         
pF1KA0 TWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_941 TWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIH
              550       560       570       580       590       600

     580       590       600       610       620       630         
pF1KA0 HVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_941 HVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETR
              610       620       630       640       650       660

     640       650       660       670       680       690         
pF1KA0 QLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_941 QLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRD
              670       680       690       700       710       720

     700       710       720       730       740       750         
pF1KA0 PGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_941 PGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQS
              730       740       750       760       770       780

     760       770       780       790       800       810         
pF1KA0 LEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_941 LEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVV
              790       800       810       820       830       840

     820       830       840       850       860       870         
pF1KA0 VEPGDTLSSPEFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_941 VEPGDTLSSPEFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLS
              850       860       870       880       890       900

     880       890       900       910       920       930         
pF1KA0 PTSLQDFVAPGPMAELVPRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_941 PTSLQDFVAPGPMAELVPRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLL
              910       920       930       940       950       960

     940       950       960       970       980       990         
pF1KA0 QLLAGAGTHGTPSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_941 QLLAGAGTHGTPSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVG
              970       980       990      1000      1010      1020

    1000      1010      1020      1030      1040      1050         
pF1KA0 CLAGEPAGSHRKRCGDLPSGASPRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_941 CLAGEPAGSHRKRCGDLPSGASPRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTA
             1030      1040      1050      1060      1070      1080

    1060  
pF1KA0 SEV
       :::
NP_941 SEV
          

>>NP_001252521 (OMIM: 611067,611101,615376) pleckstrin h  (1085 aa)
 initn: 7140 init1: 7140 opt: 7140  Z-score: 3842.3  bits: 722.7 E(85289): 2.8e-207
Smith-Waterman score: 7140; 99.9% identity (100.0% similar) in 1060 aa overlap (3-1062:26-1085)

                                      10        20        30       
pF1KA0                        MDDQSPAEKKGLRCQNPACMDKGRAAKVCHHADCQQL
                                :::::::::::::::::::::::::::::::::::
NP_001 MSLGERGSPQTFGGSSVSKGSDAGHDQSPAEKKGLRCQNPACMDKGRAAKVCHHADCQQL
               10        20        30        40        50        60

        40        50        60        70        80        90       
pF1KA0 HRRGPLNLCEACDSKFHSTMHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HRRGPLNLCEACDSKFHSTMHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEE
               70        80        90       100       110       120

       100       110       120       130       140       150       
pF1KA0 EESSVDGKGDRKSTGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EESSVDGKGDRKSTGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLG
              130       140       150       160       170       180

       160       170       180       190       200       210       
pF1KA0 EVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGM
              190       200       210       220       230       240

       220       230       240       250       260       270       
pF1KA0 KDSKSLSLPILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDSKSLSLPILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPP
              250       260       270       280       290       300

       280       290       300       310       320       330       
pF1KA0 TPSSCSLPSGSSGSTNSGDSWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYS
       ::::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::
NP_001 TPSSCSLPSGSSGSTNTGDSWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYS
              310       320       330       340       350       360

       340       350       360       370       380       390       
pF1KA0 LFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAV
              370       380       390       400       410       420

       400       410       420       430       440       450       
pF1KA0 WELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASV
              430       440       450       460       470       480

       460       470       480       490       500       510       
pF1KA0 MAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRA
              490       500       510       520       530       540

       520       530       540       550       560       570       
pF1KA0 YITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERF
              550       560       570       580       590       600

       580       590       600       610       620       630       
pF1KA0 IHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEE
              610       620       630       640       650       660

       640       650       660       670       680       690       
pF1KA0 TRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCREL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCREL
              670       680       690       700       710       720

       700       710       720       730       740       750       
pF1KA0 RDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPL
              730       740       750       760       770       780

       760       770       780       790       800       810       
pF1KA0 QSLEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSLEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAM
              790       800       810       820       830       840

       820       830       840       850       860       870       
pF1KA0 VVVEPGDTLSSPEFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVVEPGDTLSSPEFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGT
              850       860       870       880       890       900

       880       890       900       910       920       930       
pF1KA0 LSPTSLQDFVAPGPMAELVPRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSPTSLQDFVAPGPMAELVPRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEAS
              910       920       930       940       950       960

       940       950       960       970       980       990       
pF1KA0 LLQLLAGAGTHGTPSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLQLLAGAGTHGTPSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGL
              970       980       990      1000      1010      1020

      1000      1010      1020      1030      1040      1050       
pF1KA0 VGCLAGEPAGSHRKRCGDLPSGASPRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VGCLAGEPAGSHRKRCGDLPSGASPRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTL
             1030      1040      1050      1060      1070      1080

      1060  
pF1KA0 TASEV
       :::::
NP_001 TASEV
            

>>NP_001252522 (OMIM: 611067,611101,615376) pleckstrin h  (1075 aa)
 initn: 6963 init1: 6963 opt: 6969  Z-score: 3750.7  bits: 705.7 E(85289): 3.5e-202
Smith-Waterman score: 6969; 98.1% identity (98.8% similar) in 1061 aa overlap (6-1062:16-1075)

                         10        20            30        40      
pF1KA0           MDDQSPAEKKGLRCQNPACMDKGRA----AKVCHHADCQQLHRRGPLNLC
                      :.    :: ..:.    :::    ..:::::::::::::::::::
NP_001 MGTGPGVSGRLAASRPGPGLPLRDSEPS-WAGGRARDGDSQVCHHADCQQLHRRGPLNLC
               10        20         30        40        50         

         50        60        70        80        90       100      
pF1KA0 EACDSKFHSTMHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EACDSKFHSTMHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKG
      60        70        80        90       100       110         

        110       120       130       140       150       160      
pF1KA0 DRKSTGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DRKSTGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFER
     120       130       140       150       160       170         

        170       180       190       200       210       220      
pF1KA0 KGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKDSKSLSLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKDSKSLSLP
     180       190       200       210       220       230         

        230       240       250       260       270       280      
pF1KA0 ILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPS
     240       250       260       270       280       290         

        290       300       310       320       330       340      
pF1KA0 GSSGSTNSGDSWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPR
       :::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSSGSTNTGDSWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPR
     300       310       320       330       340       350         

        350       360       370       380       390       400      
pF1KA0 GLRFDHDSWEEEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLRFDHDSWEEEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEAS
     360       370       380       390       400       410         

        410       420       430       440       450       460      
pF1KA0 YIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKAR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKAR
     420       430       440       450       460       470         

        470       480       490       500       510       520      
pF1KA0 RTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHP
     480       490       500       510       520       530         

        530       540       550       560       570       580      
pF1KA0 QCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMR
     540       550       560       570       580       590         

        590       600       610       620       630       640      
pF1KA0 QRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGS
     600       610       620       630       640       650         

        650       660       670       680       690       700      
pF1KA0 LRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLI
     660       670       680       690       700       710         

        710       720       730       740       750       760      
pF1KA0 YLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDE
     720       730       740       750       760       770         

        770       780       790       800       810       820      
pF1KA0 QEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTL
     780       790       800       810       820       830         

        830       840       850       860       870       880      
pF1KA0 SSPEFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSPEFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDF
     840       850       860       870       880       890         

        890       900       910       920       930       940      
pF1KA0 VAPGPMAELVPRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLLQLLAGAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VAPGPMAELVPRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLLQLLAGAG
     900       910       920       930       940       950         

        950       960       970       980       990      1000      
pF1KA0 THGTPSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 THGTPSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPA
     960       970       980       990      1000      1010         

       1010      1020      1030      1040      1050      1060  
pF1KA0 GSHRKRCGDLPSGASPRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTASEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSHRKRCGDLPSGASPRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTASEV
    1020      1030      1040      1050      1060      1070     

>>NP_001036130 (OMIM: 611067,611101,615376) pleckstrin h  (1006 aa)
 initn: 6734 init1: 6734 opt: 6734  Z-score: 3625.2  bits: 682.4 E(85289): 3.5e-195
Smith-Waterman score: 6734; 99.9% identity (100.0% similar) in 1006 aa overlap (57-1062:1-1006)

         30        40        50        60        70        80      
pF1KA0 KVCHHADCQQLHRRGPLNLCEACDSKFHSTMHYDGHVRFDLPPQGSVLARNVSTRSCPPR
                                     ::::::::::::::::::::::::::::::
NP_001                               MHYDGHVRFDLPPQGSVLARNVSTRSCPPR
                                             10        20        30

         90       100       110       120       130       140      
pF1KA0 TSPAVDLEEEEEESSVDGKGDRKSTGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TSPAVDLEEEEEESSVDGKGDRKSTGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETE
               40        50        60        70        80        90

        150       160       170       180       190       200      
pF1KA0 IVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAPAK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAPAK
              100       110       120       130       140       150

        210       220       230       240       250       260      
pF1KA0 PGDEGKVEQGMKDSKSLSLPILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGDEGKVEQGMKDSKSLSLPILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFL
              160       170       180       190       200       210

        270       280       290       300       310       320      
pF1KA0 GEASIPGQEPPTPSSCSLPSGSSGSTNSGDSWKNRAASRFSGFFSSGPSTSAFGREVDKM
       :::::::::::::::::::::::::::.::::::::::::::::::::::::::::::::
NP_001 GEASIPGQEPPTPSSCSLPSGSSGSTNTGDSWKNRAASRFSGFFSSGPSTSAFGREVDKM
              220       230       240       250       260       270

        330       340       350       360       370       380      
pF1KA0 EQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWRELIDGHEKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWRELIDGHEKL
              280       290       300       310       320       330

        390       400       410       420       430       440      
pF1KA0 TRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEI
              340       350       360       370       380       390

        450       460       470       480       490       500      
pF1KA0 AQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMR
              400       410       420       430       440       450

        510       520       530       540       550       560      
pF1KA0 GLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEA
              460       470       480       490       500       510

        570       580       590       600       610       620      
pF1KA0 VVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDL
              520       530       540       550       560       570

        630       640       650       660       670       680      
pF1KA0 TAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPP
              580       590       600       610       620       630

        690       700       710       720       730       740      
pF1KA0 LLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLR
              640       650       660       670       680       690

        750       760       770       780       790       800      
pF1KA0 AQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHC
              700       710       720       730       740       750

        810       820       830       840       850       860      
pF1KA0 ASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDG
              760       770       780       790       800       810

        870       880       890       900       910       920      
pF1KA0 RSCSMDSAYGTLSPTSLQDFVAPGPMAELVPRAPESPRVPSPPPSPRLRRRTPVQLLSCP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSCSMDSAYGTLSPTSLQDFVAPGPMAELVPRAPESPRVPSPPPSPRLRRRTPVQLLSCP
              820       830       840       850       860       870

        930       940       950       960       970       980      
pF1KA0 PHLLKSKSEASLLQLLAGAGTHGTPSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PHLLKSKSEASLLQLLAGAGTHGTPSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCR
              880       890       900       910       920       930

        990      1000      1010      1020      1030      1040      
pF1KA0 GAPSPGSGPGLVGCLAGEPAGSHRKRCGDLPSGASPRVQPEPPPGVSAQHRKLTLAQLYR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GAPSPGSGPGLVGCLAGEPAGSHRKRCGDLPSGASPRVQPEPPPGVSAQHRKLTLAQLYR
              940       950       960       970       980       990

       1050      1060  
pF1KA0 IRTTLLLNSTLTASEV
       ::::::::::::::::
NP_001 IRTTLLLNSTLTASEV
             1000      

>>NP_001036129 (OMIM: 611067,611101,615376) pleckstrin h  (1006 aa)
 initn: 6734 init1: 6734 opt: 6734  Z-score: 3625.2  bits: 682.4 E(85289): 3.5e-195
Smith-Waterman score: 6734; 99.9% identity (100.0% similar) in 1006 aa overlap (57-1062:1-1006)

         30        40        50        60        70        80      
pF1KA0 KVCHHADCQQLHRRGPLNLCEACDSKFHSTMHYDGHVRFDLPPQGSVLARNVSTRSCPPR
                                     ::::::::::::::::::::::::::::::
NP_001                               MHYDGHVRFDLPPQGSVLARNVSTRSCPPR
                                             10        20        30

         90       100       110       120       130       140      
pF1KA0 TSPAVDLEEEEEESSVDGKGDRKSTGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TSPAVDLEEEEEESSVDGKGDRKSTGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETE
               40        50        60        70        80        90

        150       160       170       180       190       200      
pF1KA0 IVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAPAK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAPAK
              100       110       120       130       140       150

        210       220       230       240       250       260      
pF1KA0 PGDEGKVEQGMKDSKSLSLPILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGDEGKVEQGMKDSKSLSLPILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFL
              160       170       180       190       200       210

        270       280       290       300       310       320      
pF1KA0 GEASIPGQEPPTPSSCSLPSGSSGSTNSGDSWKNRAASRFSGFFSSGPSTSAFGREVDKM
       :::::::::::::::::::::::::::.::::::::::::::::::::::::::::::::
NP_001 GEASIPGQEPPTPSSCSLPSGSSGSTNTGDSWKNRAASRFSGFFSSGPSTSAFGREVDKM
              220       230       240       250       260       270

        330       340       350       360       370       380      
pF1KA0 EQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWRELIDGHEKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWRELIDGHEKL
              280       290       300       310       320       330

        390       400       410       420       430       440      
pF1KA0 TRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEI
              340       350       360       370       380       390

        450       460       470       480       490       500      
pF1KA0 AQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMR
              400       410       420       430       440       450

        510       520       530       540       550       560      
pF1KA0 GLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEA
              460       470       480       490       500       510

        570       580       590       600       610       620      
pF1KA0 VVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDL
              520       530       540       550       560       570

        630       640       650       660       670       680      
pF1KA0 TAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPP
              580       590       600       610       620       630

        690       700       710       720       730       740      
pF1KA0 LLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLR
              640       650       660       670       680       690

        750       760       770       780       790       800      
pF1KA0 AQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHC
              700       710       720       730       740       750

        810       820       830       840       850       860      
pF1KA0 ASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDG
              760       770       780       790       800       810

        870       880       890       900       910       920      
pF1KA0 RSCSMDSAYGTLSPTSLQDFVAPGPMAELVPRAPESPRVPSPPPSPRLRRRTPVQLLSCP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSCSMDSAYGTLSPTSLQDFVAPGPMAELVPRAPESPRVPSPPPSPRLRRRTPVQLLSCP
              820       830       840       850       860       870

        930       940       950       960       970       980      
pF1KA0 PHLLKSKSEASLLQLLAGAGTHGTPSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PHLLKSKSEASLLQLLAGAGTHGTPSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCR
              880       890       900       910       920       930

        990      1000      1010      1020      1030      1040      
pF1KA0 GAPSPGSGPGLVGCLAGEPAGSHRKRCGDLPSGASPRVQPEPPPGVSAQHRKLTLAQLYR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GAPSPGSGPGLVGCLAGEPAGSHRKRCGDLPSGASPRVQPEPPPGVSAQHRKLTLAQLYR
              940       950       960       970       980       990

       1050      1060  
pF1KA0 IRTTLLLNSTLTASEV
       ::::::::::::::::
NP_001 IRTTLLLNSTLTASEV
             1000      

>>NP_065682 (OMIM: 611067,611101,615376) pleckstrin homo  (1006 aa)
 initn: 6734 init1: 6734 opt: 6734  Z-score: 3625.2  bits: 682.4 E(85289): 3.5e-195
Smith-Waterman score: 6734; 99.9% identity (100.0% similar) in 1006 aa overlap (57-1062:1-1006)

         30        40        50        60        70        80      
pF1KA0 KVCHHADCQQLHRRGPLNLCEACDSKFHSTMHYDGHVRFDLPPQGSVLARNVSTRSCPPR
                                     ::::::::::::::::::::::::::::::
NP_065                               MHYDGHVRFDLPPQGSVLARNVSTRSCPPR
                                             10        20        30

         90       100       110       120       130       140      
pF1KA0 TSPAVDLEEEEEESSVDGKGDRKSTGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 TSPAVDLEEEEEESSVDGKGDRKSTGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETE
               40        50        60        70        80        90

        150       160       170       180       190       200      
pF1KA0 IVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAPAK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 IVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAPAK
              100       110       120       130       140       150

        210       220       230       240       250       260      
pF1KA0 PGDEGKVEQGMKDSKSLSLPILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 PGDEGKVEQGMKDSKSLSLPILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFL
              160       170       180       190       200       210

        270       280       290       300       310       320      
pF1KA0 GEASIPGQEPPTPSSCSLPSGSSGSTNSGDSWKNRAASRFSGFFSSGPSTSAFGREVDKM
       :::::::::::::::::::::::::::.::::::::::::::::::::::::::::::::
NP_065 GEASIPGQEPPTPSSCSLPSGSSGSTNTGDSWKNRAASRFSGFFSSGPSTSAFGREVDKM
              220       230       240       250       260       270

        330       340       350       360       370       380      
pF1KA0 EQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWRELIDGHEKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 EQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWRELIDGHEKL
              280       290       300       310       320       330

        390       400       410       420       430       440      
pF1KA0 TRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 TRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEI
              340       350       360       370       380       390

        450       460       470       480       490       500      
pF1KA0 AQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 AQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMR
              400       410       420       430       440       450

        510       520       530       540       550       560      
pF1KA0 GLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 GLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEA
              460       470       480       490       500       510

        570       580       590       600       610       620      
pF1KA0 VVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 VVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDL
              520       530       540       550       560       570

        630       640       650       660       670       680      
pF1KA0 TAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 TAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPP
              580       590       600       610       620       630

        690       700       710       720       730       740      
pF1KA0 LLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 LLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLR
              640       650       660       670       680       690

        750       760       770       780       790       800      
pF1KA0 AQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 AQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHC
              700       710       720       730       740       750

        810       820       830       840       850       860      
pF1KA0 ASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 ASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDG
              760       770       780       790       800       810

        870       880       890       900       910       920      
pF1KA0 RSCSMDSAYGTLSPTSLQDFVAPGPMAELVPRAPESPRVPSPPPSPRLRRRTPVQLLSCP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 RSCSMDSAYGTLSPTSLQDFVAPGPMAELVPRAPESPRVPSPPPSPRLRRRTPVQLLSCP
              820       830       840       850       860       870

        930       940       950       960       970       980      
pF1KA0 PHLLKSKSEASLLQLLAGAGTHGTPSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 PHLLKSKSEASLLQLLAGAGTHGTPSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCR
              880       890       900       910       920       930

        990      1000      1010      1020      1030      1040      
pF1KA0 GAPSPGSGPGLVGCLAGEPAGSHRKRCGDLPSGASPRVQPEPPPGVSAQHRKLTLAQLYR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 GAPSPGSGPGLVGCLAGEPAGSHRKRCGDLPSGASPRVQPEPPPGVSAQHRKLTLAQLYR
              940       950       960       970       980       990

       1050      1060  
pF1KA0 IRTTLLLNSTLTASEV
       ::::::::::::::::
NP_065 IRTTLLLNSTLTASEV
             1000      

>>NP_001252523 (OMIM: 611067,611101,615376) pleckstrin h  (930 aa)
 initn: 6078 init1: 6078 opt: 6091  Z-score: 3281.1  bits: 618.6 E(85289): 5.1e-176
Smith-Waterman score: 6091; 98.6% identity (99.2% similar) in 928 aa overlap (57-984:1-926)

         30        40        50        60        70        80      
pF1KA0 KVCHHADCQQLHRRGPLNLCEACDSKFHSTMHYDGHVRFDLPPQGSVLARNVSTRSCPPR
                                     ::::::::::::::::::::::::::::::
NP_001                               MHYDGHVRFDLPPQGSVLARNVSTRSCPPR
                                             10        20        30

         90       100       110       120       130       140      
pF1KA0 TSPAVDLEEEEEESSVDGKGDRKSTGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TSPAVDLEEEEEESSVDGKGDRKSTGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETE
               40        50        60        70        80        90

        150       160       170       180       190       200      
pF1KA0 IVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAPAK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAPAK
              100       110       120       130       140       150

        210       220       230       240       250       260      
pF1KA0 PGDEGKVEQGMKDSKSLSLPILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGDEGKVEQGMKDSKSLSLPILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFL
              160       170       180       190       200       210

        270       280       290       300       310       320      
pF1KA0 GEASIPGQEPPTPSSCSLPSGSSGSTNSGDSWKNRAASRFSGFFSSGPSTSAFGREVDKM
       :::::::::::::::::::::::::::.::::::::::::::::::::::::::::::::
NP_001 GEASIPGQEPPTPSSCSLPSGSSGSTNTGDSWKNRAASRFSGFFSSGPSTSAFGREVDKM
              220       230       240       250       260       270

        330       340       350       360       370       380      
pF1KA0 EQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWRELIDGHEKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWRELIDGHEKL
              280       290       300       310       320       330

        390       400       410       420       430       440      
pF1KA0 TRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEI
              340       350       360       370       380       390

        450       460       470       480       490       500      
pF1KA0 AQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMR
              400       410       420       430       440       450

        510       520       530       540       550       560      
pF1KA0 GLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEA
              460       470       480       490       500       510

        570       580       590       600       610       620      
pF1KA0 VVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDL
              520       530       540       550       560       570

        630       640       650       660       670       680      
pF1KA0 TAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPP
              580       590       600       610       620       630

        690       700       710       720       730       740      
pF1KA0 LLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLR
              640       650       660       670       680       690

        750       760       770       780       790       800      
pF1KA0 AQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHC
              700       710       720       730       740       750

        810       820       830       840       850       860      
pF1KA0 ASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDG
              760       770       780       790       800       810

        870       880       890       900       910       920      
pF1KA0 RSCSMDSAYGTLSPTSLQDFVAPGPMAELVPRAPESPRVPSPPPSPRLRRRTPVQLLSCP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSCSMDSAYGTLSPTSLQDFVAPGPMAELVPRAPESPRVPSPPPSPRLRRRTPVQLLSCP
              820       830       840       850       860       870

        930       940       950       960       970       980      
pF1KA0 PHLLKSKSEASLLQLLAGAGTHGTPSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCR
       ::::::::::::::::::::::::::::::::::::::::::.   ...:  : :. :  
NP_001 PHLLKSKSEASLLQLLAGAGTHGTPSAPSRSLSELCLAVPAPA--QEADPGPALPNQDHP
              880       890       900       910         920        

        990      1000      1010      1020      1030      1040      
pF1KA0 GAPSPGSGPGLVGCLAGEPAGSHRKRCGDLPSGASPRVQPEPPPGVSAQHRKLTLAQLYR
                                                                   
NP_001 AA                                                          
      930                                                          

>>NP_001138329 (OMIM: 611743) pleckstrin homology domain  (758 aa)
 initn: 1467 init1: 1272 opt: 1391  Z-score: 763.4  bits: 152.4 E(85289): 8.8e-36
Smith-Waterman score: 1458; 36.7% identity (62.0% similar) in 768 aa overlap (305-1062:50-758)

          280       290       300       310       320       330    
pF1KA0 EPPTPSSCSLPSGSSGSTNSGDSWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLH
                                     : .:  ..:   :   .:. : ..:: .::
NP_001 RLQQYVPFARGSGQARGLSPMRLRDPEPEKRHGGHVGAGLLHSPKLKELTKAHELEVRLH
      20        30        40        50        60        70         

          340       350       360       370       380       390    
pF1KA0 TYSLFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQ
       :.:.::.::::     :.  ::      :  :.. : .: :::::. ::...... ::::
NP_001 TFSMFGMPRLP---PEDRRHWEI----GEGGDSG-LTIEKSWRELVPGHKEMSQELCHQQ
      80        90              100        110       120       130 

          400       410       420       430       440       450    
pF1KA0 EAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLW
       ::.:::: ::  :.:::... .:.   :::::. ::: :: :: ::.:.: . . :: .:
NP_001 EALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFW
             140       150       160       170       180       190 

          460       470       480       490       500       510    
pF1KA0 ASVMAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDL
         :..:.::..: .   :.:  . .::  ::. :.::..::.. .  : : :   . : :
NP_001 DEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPL
             200       210       220       230       240       250 

          520       530       540       550       560       570    
pF1KA0 FRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSV
       :.:.. : ::: .  :  : :.: :::::.:::::::..::... : ::.::. ::: .:
NP_001 FHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAV
             260       270       280       290       300       310 

          580       590       600       610       620       630    
pF1KA0 ERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGAS
       : :..:.:. .:: .:.. :::...::  :::.:  ::::.: :. :  ::::.:. :..
NP_001 ESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVA
             320       330       340       350       360       370 

          640       650       660       670       680       690    
pF1KA0 PEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVC
        :.:::::::: .:.:::...:.::: :::.:.:::::  .::....::::::...:.::
NP_001 SEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRKADKAKVIRPPLMLEKLVC
             380       390       400       410       420       430 

          700       710       720       730       740       750    
pF1KA0 RELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQ
       . ::::.:::::.:.::. . .:   .  . .    :..   .::  ::.:.:.:   ..
NP_001 QPLRDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKAEEYVQQK
             440       450       460       470       480       490 

          760       770       780       790       800       810    
pF1KA0 QPLQSLEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTET
       . : .: ...:..                      ::.  : :. : .... ...: :  
NP_001 RELLTLYRDQDRE----------------------SPST-RPSTPSLEGSQSSAEGRTPE
             500                              510       520        

          820       830       840       850       860       870    
pF1KA0 LAMVVVEPGDTLSSPEFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSA
       .. ..  :  ...    ...:.  ..   :   :   .:::.   ::. .  :.   :  
NP_001 FSTII--PHLVVTEDTDEDAPLVPDDTSDSGYGTLIPGTPTGSRSPLSRLRQRALRRDPR
      530         540       550       560       570       580      

          880       890       900       910       920       930    
pF1KA0 YGTLSPTSLQDFVAPGPMAELVPRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKS
         :.:   :.:.    :.    :  :..:.  : :  :.   .        ::   . ..
NP_001 L-TFSTLELRDI----PLRPHPPD-PQAPQRRSAPELPEGILKGGSLPQEDPPTWSEEED
         590           600        610       620       630       640

               940       950        960       970       980        
pF1KA0 EAS-----LLQLLAGAGTHGT-PSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCRGA
        ::     ... :  :  .:  ::.:... :    :  .:  ...:  .: :: .   : 
NP_001 GASERGNVVVETLHRARLRGQLPSSPTHADS----AGESPW-ESSGEEEEEGPLFLKAGH
              650       660       670            680       690     

      990        1000      1010      1020      1030      1040      
pF1KA0 PS--PGSGPGLVGCLAGEPAGSHRKRCGDLPSGASPRVQPEPPPGVSAQHRKLTLAQLYR
        :  :  .  ..  .  : : :.: . .. :  . ::              ::: ::: :
NP_001 TSLRPMRAEDMLREIREELA-SQRIEGAEEPRDSRPR--------------KLTRAQLQR
         700       710        720       730                     740

       1050        1060  
pF1KA0 IRTT--LLLNSTLTASEV
       .:    . :.. :.::::
NP_001 MRGPHIIQLDTPLSASEV
              750        

>>XP_011519269 (OMIM: 611743) PREDICTED: pleckstrin homo  (768 aa)
 initn: 1435 init1: 1272 opt: 1391  Z-score: 763.3  bits: 152.4 E(85289): 8.9e-36
Smith-Waterman score: 1458; 36.7% identity (62.0% similar) in 768 aa overlap (305-1062:60-768)

          280       290       300       310       320       330    
pF1KA0 EPPTPSSCSLPSGSSGSTNSGDSWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLH
                                     : .:  ..:   :   .:. : ..:: .::
XP_011 DSIPEDTLCWGSGQARGLSPMRLRDPEPEKRHGGHVGAGLLHSPKLKELTKAHELEVRLH
      30        40        50        60        70        80         

          340       350       360       370       380       390    
pF1KA0 TYSLFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQ
       :.:.::.::::     :.  ::      :  :.. : .: :::::. ::...... ::::
XP_011 TFSMFGMPRLP---PEDRRHWEI----GEGGDSG-LTIEKSWRELVPGHKEMSQELCHQQ
      90       100              110        120       130       140 

          400       410       420       430       440       450    
pF1KA0 EAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLW
       ::.:::: ::  :.:::... .:.   :::::. ::: :: :: ::.:.: . . :: .:
XP_011 EALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFW
             150       160       170       180       190       200 

          460       470       480       490       500       510    
pF1KA0 ASVMAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDL
         :..:.::..: .   :.:  . .::  ::. :.::..::.. .  : : :   . : :
XP_011 DEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPL
             210       220       230       240       250       260 

          520       530       540       550       560       570    
pF1KA0 FRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSV
       :.:.. : ::: .  :  : :.: :::::.:::::::..::... : ::.::. ::: .:
XP_011 FHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAV
             270       280       290       300       310       320 

          580       590       600       610       620       630    
pF1KA0 ERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGAS
       : :..:.:. .:: .:.. :::...::  :::.:  ::::.: :. :  ::::.:. :..
XP_011 ESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVA
             330       340       350       360       370       380 

          640       650       660       670       680       690    
pF1KA0 PEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVC
        :.:::::::: .:.:::...:.::: :::.:.:::::  .::....::::::...:.::
XP_011 SEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRKADKAKVIRPPLMLEKLVC
             390       400       410       420       430       440 

          700       710       720       730       740       750    
pF1KA0 RELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQ
       . ::::.:::::.:.::. . .:   .  . .    :..   .::  ::.:.:.:   ..
XP_011 QPLRDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKAEEYVQQK
             450       460       470       480       490       500 

          760       770       780       790       800       810    
pF1KA0 QPLQSLEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTET
       . : .: ...:..                      ::.  : :. : .... ...: :  
XP_011 RELLTLYRDQDRE----------------------SPST-RPSTPSLEGSQSSAEGRTPE
             510                              520       530        

          820       830       840       850       860       870    
pF1KA0 LAMVVVEPGDTLSSPEFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSA
       .. ..  :  ...    ...:.  ..   :   :   .:::.   ::. .  :.   :  
XP_011 FSTII--PHLVVTEDTDEDAPLVPDDTSDSGYGTLIPGTPTGSRSPLSRLRQRALRRDPR
      540         550       560       570       580       590      

          880       890       900       910       920       930    
pF1KA0 YGTLSPTSLQDFVAPGPMAELVPRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKS
         :.:   :.:.    :.    :  :..:.  : :  :.   .        ::   . ..
XP_011 L-TFSTLELRDI----PLRPHPPD-PQAPQRRSAPELPEGILKGGSLPQEDPPTWSEEED
         600           610        620       630       640       650

               940       950        960       970       980        
pF1KA0 EAS-----LLQLLAGAGTHGT-PSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCRGA
        ::     ... :  :  .:  ::.:... :    :  .:  ...:  .: :: .   : 
XP_011 GASERGNVVVETLHRARLRGQLPSSPTHADS----AGESPW-ESSGEEEEEGPLFLKAGH
              660       670       680            690       700     

      990        1000      1010      1020      1030      1040      
pF1KA0 PS--PGSGPGLVGCLAGEPAGSHRKRCGDLPSGASPRVQPEPPPGVSAQHRKLTLAQLYR
        :  :  .  ..  .  : : :.: . .. :  . ::              ::: ::: :
XP_011 TSLRPMRAEDMLREIREELA-SQRIEGAEEPRDSRPR--------------KLTRAQLQR
         710       720        730       740                     750

       1050        1060  
pF1KA0 IRTT--LLLNSTLTASEV
       .:    . :.. :.::::
XP_011 MRGPHIIQLDTPLSASEV
              760        




1062 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 10:05:28 2016 done: Thu Nov  3 10:05:31 2016
 Total Scan time: 16.920 Total Display time:  0.300

Function used was FASTA [36.3.4 Apr, 2011]
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