Result of FASTA (omim) for pF1KA0583
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KA0583, 1919 aa
  1>>>pF1KA0583 1919 - 1919 aa - 1919 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 15.8042+/-0.000565; mu= -26.2587+/- 0.035
 mean_var=559.8671+/-115.909, 0's: 0 Z-trim(120.2): 215  B-trim: 0 in 0/56
 Lambda= 0.054204
 statistics sampled from 34923 (35138) to 34923 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.713), E-opt: 0.2 (0.412), width:  16
 Scan time: 22.120

The best scores are:                                      opt bits E(85289)
NP_004738 (OMIM: 604090) disks large homolog 5 [Ho (1919) 12665 1007.0       0
XP_005270333 (OMIM: 604090) PREDICTED: disks large (1915) 12612 1002.9       0
XP_011538643 (OMIM: 604090) PREDICTED: disks large (1860) 12025 957.0       0
XP_011538644 (OMIM: 604090) PREDICTED: disks large (1829) 12018 956.4       0
XP_016872402 (OMIM: 604090) PREDICTED: disks large (1825) 12016 956.3       0
XP_016872403 (OMIM: 604090) PREDICTED: disks large (1809) 11965 952.3       0
XP_011538646 (OMIM: 604090) PREDICTED: disks large (1807) 11884 946.0       0
XP_011538647 (OMIM: 604090) PREDICTED: disks large (1764) 11690 930.8       0
XP_011538648 (OMIM: 604090) PREDICTED: disks large (1680) 10924 870.9       0
XP_016872404 (OMIM: 604090) PREDICTED: disks large (1613) 10688 852.4       0
XP_011538649 (OMIM: 604090) PREDICTED: disks large (1613) 10688 852.4       0
XP_006718120 (OMIM: 604090) PREDICTED: disks large (1342) 8832 707.2 2.8e-202
XP_006718119 (OMIM: 604090) PREDICTED: disks large (1579) 5240 426.4 1.2e-117
XP_016861309 (OMIM: 601014) PREDICTED: disks large ( 853)  412 48.7 0.00031
XP_011510808 (OMIM: 601014) PREDICTED: disks large ( 853)  412 48.7 0.00031
XP_016861311 (OMIM: 601014) PREDICTED: disks large ( 821)  411 48.6 0.00032
NP_001191317 (OMIM: 601014) disks large homolog 1  ( 788)  405 48.1 0.00042
NP_001091894 (OMIM: 601014) disks large homolog 1  ( 904)  407 48.3 0.00042
NP_001277912 (OMIM: 601014) disks large homolog 1  ( 904)  407 48.3 0.00042
XP_016861294 (OMIM: 601014) PREDICTED: disks large ( 904)  407 48.3 0.00042
XP_011510804 (OMIM: 601014) PREDICTED: disks large ( 904)  407 48.3 0.00042
XP_016861308 (OMIM: 601014) PREDICTED: disks large ( 871)  405 48.1 0.00046
XP_016861305 (OMIM: 601014) PREDICTED: disks large ( 871)  405 48.1 0.00046
XP_016861306 (OMIM: 601014) PREDICTED: disks large ( 871)  405 48.1 0.00046
XP_016861307 (OMIM: 601014) PREDICTED: disks large ( 871)  405 48.1 0.00046
XP_011510807 (OMIM: 601014) PREDICTED: disks large ( 871)  405 48.1 0.00046
NP_001191316 (OMIM: 601014) disks large homolog 1  ( 800)  385 46.6  0.0013
XP_016861313 (OMIM: 601014) PREDICTED: disks large ( 519)  346 43.4  0.0072


>>NP_004738 (OMIM: 604090) disks large homolog 5 [Homo s  (1919 aa)
 initn: 12665 init1: 12665 opt: 12665  Z-score: 5370.1  bits: 1007.0 E(85289):    0
Smith-Waterman score: 12665; 99.9% identity (100.0% similar) in 1919 aa overlap (1-1919:1-1919)

               10        20        30        40        50        60
pF1KA0 MEPQRRELLAQCQQSLAQAMTEVEAVLGLLEAAGALSPGERRQLDEEAGGAKAELLLKLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MEPQRRELLAQCQQSLAQAMTEVEAVLGLLEAAGALSPGERRQLDEEAGGAKAELLLKLL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 LAKERDHFQDLRAALEKTQPHLLPILYLNGVVGPPQPAEGAGSTYSVLSTMPSDSESSSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LAKERDHFQDLRAALEKTQPHLLPILYLNGVVGPPQPAEGAGSTYSVLSTMPSDSESSSS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 LSSVGTTGKAPSPPPLLTDRQVNEKVENLSIQLRLMTRERNELRKRLAFATHGTAFDKRP
       :::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::
NP_004 LSSVGTTGKAPSPPPLLTDQQVNEKVENLSIQLRLMTRERNELRKRLAFATHGTAFDKRP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 YHRLNPDYERLKIQCVRAMSDLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLSDQTRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 YHRLNPDYERLKIQCVRAMSDLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLSDQTRL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA0 KDDVDMLRRENGQLLRERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSSEILN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KDDVDMLRRENGQLLRERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSSEILN
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA0 KLYDTAMDKLEVVKKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KLYDTAMDKLEVVKKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRD
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA0 TAIQLQHQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TAIQLQHQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEK
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KA0 YREERDAVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAANEEMEALRQI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 YREERDAVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAANEEMEALRQI
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KA0 KDTVTMDAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERDSI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KDTVTMDAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERDSI
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KA0 RTLCDNLRRERDRAVSELAEALRSLDDTRKQKNDVSRELKELKEQMESQLEKEARFRQLM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 RTLCDNLRRERDRAVSELAEALRSLDDTRKQKNDVSRELKELKEQMESQLEKEARFRQLM
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KA0 AHSSHDSAIDTDSMEWETEVVEFERETEDIDLKALGFDMAEGVNEPCFPGDCGIFVTKVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 AHSSHDSAIDTDSMEWETEVVEFERETEDIDLKALGFDMAEGVNEPCFPGDCGIFVTKVD
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KA0 KGSIADGRLRVNDWLLRINDVDLINKDKKQAIKALLNGEGAINMVVRRRKSLGGKVVTPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KGSIADGRLRVNDWLLRINDVDLINKDKKQAIKALLNGEGAINMVVRRRKSLGGKVVTPL
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KA0 HINLSGQKDSGISLENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 HINLSGQKDSGISLENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESL
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KA0 LRSCQDSLTLSLLKVFPQSSSWSGQNIFENIKDSDKMLSFRAHGPEVQAHNKRNLIQHNN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LRSCQDSLTLSLLKVFPQSSSWSGQNIFENIKDSDKMLSFRAHGPEVQAHNKRNLIQHNN
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KA0 STQTDIFYTDRLEDRKEPGPPGGSSSFLHKPFPGGPLQVCPQACPSASERSLSSFRSDAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 STQTDIFYTDRLEDRKEPGPPGGSSSFLHKPFPGGPLQVCPQACPSASERSLSSFRSDAS
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KA0 GDRGFGLVDVRGRRPLLPFETEVGPCGVGEASLDKADSEGSNSGGTWPKAMLSSTAVPEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GDRGFGLVDVRGRRPLLPFETEVGPCGVGEASLDKADSEGSNSGGTWPKAMLSSTAVPEK
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KA0 LSVYKKPKQRKSIFDPNTFKRPQTPPKIDYLLPGPGPAHSPQPSKRAGPLTPPKPPRRSD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LSVYKKPKQRKSIFDPNTFKRPQTPPKIDYLLPGPGPAHSPQPSKRAGPLTPPKPPRRSD
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KA0 SIKFQHRLETSSESEATLVGSSPSTSPPSALPPDVDPGEPMHASPPRKARVRIASSYYPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SIKFQHRLETSSESEATLVGSSPSTSPPSALPPDVDPGEPMHASPPRKARVRIASSYYPE
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KA0 GDGDSSHLPAKKSCDEDLTSQKVDELGQKRRRPKSAPSFRPKLAPVVIPAQFLEEQKCVP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GDGDSSHLPAKKSCDEDLTSQKVDELGQKRRRPKSAPSFRPKLAPVVIPAQFLEEQKCVP
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KA0 ASGELSPELQEWAPYSPGHSSRHSNPPLYPSRPSVGTVPRSLTPSTTVSSILRNPIYTVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 ASGELSPELQEWAPYSPGHSSRHSNPPLYPSRPSVGTVPRSLTPSTTVSSILRNPIYTVR
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KA0 SHRVGPCSSPPAARDAGPQGLHPSVQHQGRLSLDLSHRTCSDYSEMRATHGSNSLPSSAR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SHRVGPCSSPPAARDAGPQGLHPSVQHQGRLSLDLSHRTCSDYSEMRATHGSNSLPSSAR
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KA0 LGSSSNLQFKAERIKIPSTPRYPRSVVGSERGSVSHSECSTPPQSPLNIDTLSSCSQSQT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LGSSSNLQFKAERIKIPSTPRYPRSVVGSERGSVSHSECSTPPQSPLNIDTLSSCSQSQT
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KA0 SASTLPRIAVNPASLGERRKDRPYVEEPRHVKVQKGSEPLGISIVSGEKGGIYVSKVTVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SASTLPRIAVNPASLGERRKDRPYVEEPRHVKVQKGSEPLGISIVSGEKGGIYVSKVTVG
             1330      1340      1350      1360      1370      1380

             1390      1400      1410      1420      1430      1440
pF1KA0 SIAHQAGLEYGDQLLEFNGINLRSATEQQARLIIGQQCDTITILAQYNPHVHQLSSHSRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SIAHQAGLEYGDQLLEFNGINLRSATEQQARLIIGQQCDTITILAQYNPHVHQLSSHSRS
             1390      1400      1410      1420      1430      1440

             1450      1460      1470      1480      1490      1500
pF1KA0 SSHLDPAGTHSTLQGSGTTTPEHPSVIDPLMEQDEGPSTPPAKQSSSRIAGDANKKTLEP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SSHLDPAGTHSTLQGSGTTTPEHPSVIDPLMEQDEGPSTPPAKQSSSRIAGDANKKTLEP
             1450      1460      1470      1480      1490      1500

             1510      1520      1530      1540      1550      1560
pF1KA0 RVVFIKKSQLELGVHLCGGNLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVRNKTV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 RVVFIKKSQLELGVHLCGGNLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVRNKTV
             1510      1520      1530      1540      1550      1560

             1570      1580      1590      1600      1610      1620
pF1KA0 EEVYVEMLKPRDGVRLKVQYRPEEFTKAKGLPGDSFYIRALYDRLADVEQELSFKKDDIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EEVYVEMLKPRDGVRLKVQYRPEEFTKAKGLPGDSFYIRALYDRLADVEQELSFKKDDIL
             1570      1580      1590      1600      1610      1620

             1630      1640      1650      1660      1670      1680
pF1KA0 YVDDTLPQGTFGSWMAWQLDENAQKIQRGQIPSKYVMDQEFSRRLSMSEVKDDNSATKTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 YVDDTLPQGTFGSWMAWQLDENAQKIQRGQIPSKYVMDQEFSRRLSMSEVKDDNSATKTL
             1630      1640      1650      1660      1670      1680

             1690      1700      1710      1720      1730      1740
pF1KA0 SAAARRSFFRRKHKHKRSGSKDGKDLLALDAFSSDSIPLFEDSVSLAYQRVQKVDCTALR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SAAARRSFFRRKHKHKRSGSKDGKDLLALDAFSSDSIPLFEDSVSLAYQRVQKVDCTALR
             1690      1700      1710      1720      1730      1740

             1750      1760      1770      1780      1790      1800
pF1KA0 PVLILGPLLDVVKEMLVNEAPGKFCRCPLEVMKASQQAIERGVKDCLFVDYKRRSGHFDV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 PVLILGPLLDVVKEMLVNEAPGKFCRCPLEVMKASQQAIERGVKDCLFVDYKRRSGHFDV
             1750      1760      1770      1780      1790      1800

             1810      1820      1830      1840      1850      1860
pF1KA0 TTVASIKEITEKNRHCLLDIAPHAIERLHHMHIYPIVIFIHYKSAKHIKEQRDPIYLRDK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TTVASIKEITEKNRHCLLDIAPHAIERLHHMHIYPIVIFIHYKSAKHIKEQRDPIYLRDK
             1810      1820      1830      1840      1850      1860

             1870      1880      1890      1900      1910         
pF1KA0 VTQRHSKEQFEAAQKLEQEYSRYFTGVIQGGALSSICTQILAMVNQEQNKVLWIPACPL
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VTQRHSKEQFEAAQKLEQEYSRYFTGVIQGGALSSICTQILAMVNQEQNKVLWIPACPL
             1870      1880      1890      1900      1910         

>>XP_005270333 (OMIM: 604090) PREDICTED: disks large hom  (1915 aa)
 initn: 11507 init1: 11507 opt: 12612  Z-score: 5347.7  bits: 1002.9 E(85289):    0
Smith-Waterman score: 12612; 99.7% identity (99.8% similar) in 1919 aa overlap (1-1919:1-1915)

               10        20        30        40        50        60
pF1KA0 MEPQRRELLAQCQQSLAQAMTEVEAVLGLLEAAGALSPGERRQLDEEAGGAKAELLLKLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEPQRRELLAQCQQSLAQAMTEVEAVLGLLEAAGALSPGERRQLDEEAGGAKAELLLKLL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 LAKERDHFQDLRAALEKTQPHLLPILYLNGVVGPPQPAEGAGSTYSVLSTMPSDSESSSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LAKERDHFQDLRAALEKTQPHLLPILYLNGVVGPPQPAEGAGSTYSVLSTMPSDSESSSS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 LSSVGTTGKAPSPPPLLTDRQVNEKVENLSIQLRLMTRERNELRKRLAFATHGTAFDKRP
       :::::::::::::::::::.::::::::::::::::::::::::::::::::::::::: 
XP_005 LSSVGTTGKAPSPPPLLTDQQVNEKVENLSIQLRLMTRERNELRKRLAFATHGTAFDKR-
              130       140       150       160       170          

              190       200       210       220       230       240
pF1KA0 YHRLNPDYERLKIQCVRAMSDLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLSDQTRL
          :::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ---LNPDYERLKIQCVRAMSDLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLSDQTRL
        180       190       200       210       220       230      

              250       260       270       280       290       300
pF1KA0 KDDVDMLRRENGQLLRERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSSEILN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KDDVDMLRRENGQLLRERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSSEILN
        240       250       260       270       280       290      

              310       320       330       340       350       360
pF1KA0 KLYDTAMDKLEVVKKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KLYDTAMDKLEVVKKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRD
        300       310       320       330       340       350      

              370       380       390       400       410       420
pF1KA0 TAIQLQHQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TAIQLQHQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEK
        360       370       380       390       400       410      

              430       440       450       460       470       480
pF1KA0 YREERDAVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAANEEMEALRQI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YREERDAVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAANEEMEALRQI
        420       430       440       450       460       470      

              490       500       510       520       530       540
pF1KA0 KDTVTMDAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERDSI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KDTVTMDAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERDSI
        480       490       500       510       520       530      

              550       560       570       580       590       600
pF1KA0 RTLCDNLRRERDRAVSELAEALRSLDDTRKQKNDVSRELKELKEQMESQLEKEARFRQLM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RTLCDNLRRERDRAVSELAEALRSLDDTRKQKNDVSRELKELKEQMESQLEKEARFRQLM
        540       550       560       570       580       590      

              610       620       630       640       650       660
pF1KA0 AHSSHDSAIDTDSMEWETEVVEFERETEDIDLKALGFDMAEGVNEPCFPGDCGIFVTKVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AHSSHDSAIDTDSMEWETEVVEFERETEDIDLKALGFDMAEGVNEPCFPGDCGIFVTKVD
        600       610       620       630       640       650      

              670       680       690       700       710       720
pF1KA0 KGSIADGRLRVNDWLLRINDVDLINKDKKQAIKALLNGEGAINMVVRRRKSLGGKVVTPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KGSIADGRLRVNDWLLRINDVDLINKDKKQAIKALLNGEGAINMVVRRRKSLGGKVVTPL
        660       670       680       690       700       710      

              730       740       750       760       770       780
pF1KA0 HINLSGQKDSGISLENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HINLSGQKDSGISLENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESL
        720       730       740       750       760       770      

              790       800       810       820       830       840
pF1KA0 LRSCQDSLTLSLLKVFPQSSSWSGQNIFENIKDSDKMLSFRAHGPEVQAHNKRNLIQHNN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LRSCQDSLTLSLLKVFPQSSSWSGQNIFENIKDSDKMLSFRAHGPEVQAHNKRNLIQHNN
        780       790       800       810       820       830      

              850       860       870       880       890       900
pF1KA0 STQTDIFYTDRLEDRKEPGPPGGSSSFLHKPFPGGPLQVCPQACPSASERSLSSFRSDAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 STQTDIFYTDRLEDRKEPGPPGGSSSFLHKPFPGGPLQVCPQACPSASERSLSSFRSDAS
        840       850       860       870       880       890      

              910       920       930       940       950       960
pF1KA0 GDRGFGLVDVRGRRPLLPFETEVGPCGVGEASLDKADSEGSNSGGTWPKAMLSSTAVPEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GDRGFGLVDVRGRRPLLPFETEVGPCGVGEASLDKADSEGSNSGGTWPKAMLSSTAVPEK
        900       910       920       930       940       950      

              970       980       990      1000      1010      1020
pF1KA0 LSVYKKPKQRKSIFDPNTFKRPQTPPKIDYLLPGPGPAHSPQPSKRAGPLTPPKPPRRSD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LSVYKKPKQRKSIFDPNTFKRPQTPPKIDYLLPGPGPAHSPQPSKRAGPLTPPKPPRRSD
        960       970       980       990      1000      1010      

             1030      1040      1050      1060      1070      1080
pF1KA0 SIKFQHRLETSSESEATLVGSSPSTSPPSALPPDVDPGEPMHASPPRKARVRIASSYYPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SIKFQHRLETSSESEATLVGSSPSTSPPSALPPDVDPGEPMHASPPRKARVRIASSYYPE
       1020      1030      1040      1050      1060      1070      

             1090      1100      1110      1120      1130      1140
pF1KA0 GDGDSSHLPAKKSCDEDLTSQKVDELGQKRRRPKSAPSFRPKLAPVVIPAQFLEEQKCVP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GDGDSSHLPAKKSCDEDLTSQKVDELGQKRRRPKSAPSFRPKLAPVVIPAQFLEEQKCVP
       1080      1090      1100      1110      1120      1130      

             1150      1160      1170      1180      1190      1200
pF1KA0 ASGELSPELQEWAPYSPGHSSRHSNPPLYPSRPSVGTVPRSLTPSTTVSSILRNPIYTVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ASGELSPELQEWAPYSPGHSSRHSNPPLYPSRPSVGTVPRSLTPSTTVSSILRNPIYTVR
       1140      1150      1160      1170      1180      1190      

             1210      1220      1230      1240      1250      1260
pF1KA0 SHRVGPCSSPPAARDAGPQGLHPSVQHQGRLSLDLSHRTCSDYSEMRATHGSNSLPSSAR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SHRVGPCSSPPAARDAGPQGLHPSVQHQGRLSLDLSHRTCSDYSEMRATHGSNSLPSSAR
       1200      1210      1220      1230      1240      1250      

             1270      1280      1290      1300      1310      1320
pF1KA0 LGSSSNLQFKAERIKIPSTPRYPRSVVGSERGSVSHSECSTPPQSPLNIDTLSSCSQSQT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LGSSSNLQFKAERIKIPSTPRYPRSVVGSERGSVSHSECSTPPQSPLNIDTLSSCSQSQT
       1260      1270      1280      1290      1300      1310      

             1330      1340      1350      1360      1370      1380
pF1KA0 SASTLPRIAVNPASLGERRKDRPYVEEPRHVKVQKGSEPLGISIVSGEKGGIYVSKVTVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SASTLPRIAVNPASLGERRKDRPYVEEPRHVKVQKGSEPLGISIVSGEKGGIYVSKVTVG
       1320      1330      1340      1350      1360      1370      

             1390      1400      1410      1420      1430      1440
pF1KA0 SIAHQAGLEYGDQLLEFNGINLRSATEQQARLIIGQQCDTITILAQYNPHVHQLSSHSRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SIAHQAGLEYGDQLLEFNGINLRSATEQQARLIIGQQCDTITILAQYNPHVHQLSSHSRS
       1380      1390      1400      1410      1420      1430      

             1450      1460      1470      1480      1490      1500
pF1KA0 SSHLDPAGTHSTLQGSGTTTPEHPSVIDPLMEQDEGPSTPPAKQSSSRIAGDANKKTLEP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSHLDPAGTHSTLQGSGTTTPEHPSVIDPLMEQDEGPSTPPAKQSSSRIAGDANKKTLEP
       1440      1450      1460      1470      1480      1490      

             1510      1520      1530      1540      1550      1560
pF1KA0 RVVFIKKSQLELGVHLCGGNLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVRNKTV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RVVFIKKSQLELGVHLCGGNLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVRNKTV
       1500      1510      1520      1530      1540      1550      

             1570      1580      1590      1600      1610      1620
pF1KA0 EEVYVEMLKPRDGVRLKVQYRPEEFTKAKGLPGDSFYIRALYDRLADVEQELSFKKDDIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EEVYVEMLKPRDGVRLKVQYRPEEFTKAKGLPGDSFYIRALYDRLADVEQELSFKKDDIL
       1560      1570      1580      1590      1600      1610      

             1630      1640      1650      1660      1670      1680
pF1KA0 YVDDTLPQGTFGSWMAWQLDENAQKIQRGQIPSKYVMDQEFSRRLSMSEVKDDNSATKTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YVDDTLPQGTFGSWMAWQLDENAQKIQRGQIPSKYVMDQEFSRRLSMSEVKDDNSATKTL
       1620      1630      1640      1650      1660      1670      

             1690      1700      1710      1720      1730      1740
pF1KA0 SAAARRSFFRRKHKHKRSGSKDGKDLLALDAFSSDSIPLFEDSVSLAYQRVQKVDCTALR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SAAARRSFFRRKHKHKRSGSKDGKDLLALDAFSSDSIPLFEDSVSLAYQRVQKVDCTALR
       1680      1690      1700      1710      1720      1730      

             1750      1760      1770      1780      1790      1800
pF1KA0 PVLILGPLLDVVKEMLVNEAPGKFCRCPLEVMKASQQAIERGVKDCLFVDYKRRSGHFDV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PVLILGPLLDVVKEMLVNEAPGKFCRCPLEVMKASQQAIERGVKDCLFVDYKRRSGHFDV
       1740      1750      1760      1770      1780      1790      

             1810      1820      1830      1840      1850      1860
pF1KA0 TTVASIKEITEKNRHCLLDIAPHAIERLHHMHIYPIVIFIHYKSAKHIKEQRDPIYLRDK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TTVASIKEITEKNRHCLLDIAPHAIERLHHMHIYPIVIFIHYKSAKHIKEQRDPIYLRDK
       1800      1810      1820      1830      1840      1850      

             1870      1880      1890      1900      1910         
pF1KA0 VTQRHSKEQFEAAQKLEQEYSRYFTGVIQGGALSSICTQILAMVNQEQNKVLWIPACPL
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VTQRHSKEQFEAAQKLEQEYSRYFTGVIQGGALSSICTQILAMVNQEQNKVLWIPACPL
       1860      1870      1880      1890      1900      1910     

>>XP_011538643 (OMIM: 604090) PREDICTED: disks large hom  (1860 aa)
 initn: 12016 init1: 12016 opt: 12025  Z-score: 5099.8  bits: 957.0 E(85289):    0
Smith-Waterman score: 12025; 99.8% identity (99.9% similar) in 1823 aa overlap (97-1919:39-1860)

         70        80        90       100       110       120      
pF1KA0 HFQDLRAALEKTQPHLLPILYLNGVVGPPQPAEGAGSTYSVLSTMPSDSESSSSLSSVGT
                                     :..: :::::::::::::::::::::::::
XP_011 VTLPWLGPRGQSGLQGQGRGTERVAWPVDSPSQG-GSTYSVLSTMPSDSESSSSLSSVGT
       10        20        30        40         50        60       

        130       140       150       160       170       180      
pF1KA0 TGKAPSPPPLLTDRQVNEKVENLSIQLRLMTRERNELRKRLAFATHGTAFDKRPYHRLNP
       :::::::::::::.::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TGKAPSPPPLLTDQQVNEKVENLSIQLRLMTRERNELRKRLAFATHGTAFDKRPYHRLNP
        70        80        90       100       110       120       

        190       200       210       220       230       240      
pF1KA0 DYERLKIQCVRAMSDLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLSDQTRLKDDVDM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DYERLKIQCVRAMSDLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLSDQTRLKDDVDM
       130       140       150       160       170       180       

        250       260       270       280       290       300      
pF1KA0 LRRENGQLLRERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSSEILNKLYDTA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRRENGQLLRERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSSEILNKLYDTA
       190       200       210       220       230       240       

        310       320       330       340       350       360      
pF1KA0 MDKLEVVKKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRDTAIQLQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MDKLEVVKKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRDTAIQLQ
       250       260       270       280       290       300       

        370       380       390       400       410       420      
pF1KA0 HQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEKYREERD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEKYREERD
       310       320       330       340       350       360       

        430       440       450       460       470       480      
pF1KA0 AVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAANEEMEALRQIKDTVTM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAANEEMEALRQIKDTVTM
       370       380       390       400       410       420       

        490       500       510       520       530       540      
pF1KA0 DAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERDSIRTLCDN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERDSIRTLCDN
       430       440       450       460       470       480       

        550       560       570       580       590       600      
pF1KA0 LRRERDRAVSELAEALRSLDDTRKQKNDVSRELKELKEQMESQLEKEARFRQLMAHSSHD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRRERDRAVSELAEALRSLDDTRKQKNDVSRELKELKEQMESQLEKEARFRQLMAHSSHD
       490       500       510       520       530       540       

        610       620       630       640       650       660      
pF1KA0 SAIDTDSMEWETEVVEFERETEDIDLKALGFDMAEGVNEPCFPGDCGIFVTKVDKGSIAD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SAIDTDSMEWETEVVEFERETEDIDLKALGFDMAEGVNEPCFPGDCGIFVTKVDKGSIAD
       550       560       570       580       590       600       

        670       680       690       700       710       720      
pF1KA0 GRLRVNDWLLRINDVDLINKDKKQAIKALLNGEGAINMVVRRRKSLGGKVVTPLHINLSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRLRVNDWLLRINDVDLINKDKKQAIKALLNGEGAINMVVRRRKSLGGKVVTPLHINLSG
       610       620       630       640       650       660       

        730       740       750       760       770       780      
pF1KA0 QKDSGISLENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESLLRSCQD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QKDSGISLENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESLLRSCQD
       670       680       690       700       710       720       

        790       800       810       820       830       840      
pF1KA0 SLTLSLLKVFPQSSSWSGQNIFENIKDSDKMLSFRAHGPEVQAHNKRNLIQHNNSTQTDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLTLSLLKVFPQSSSWSGQNIFENIKDSDKMLSFRAHGPEVQAHNKRNLIQHNNSTQTDI
       730       740       750       760       770       780       

        850       860       870       880       890       900      
pF1KA0 FYTDRLEDRKEPGPPGGSSSFLHKPFPGGPLQVCPQACPSASERSLSSFRSDASGDRGFG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FYTDRLEDRKEPGPPGGSSSFLHKPFPGGPLQVCPQACPSASERSLSSFRSDASGDRGFG
       790       800       810       820       830       840       

        910       920       930       940       950       960      
pF1KA0 LVDVRGRRPLLPFETEVGPCGVGEASLDKADSEGSNSGGTWPKAMLSSTAVPEKLSVYKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVDVRGRRPLLPFETEVGPCGVGEASLDKADSEGSNSGGTWPKAMLSSTAVPEKLSVYKK
       850       860       870       880       890       900       

        970       980       990      1000      1010      1020      
pF1KA0 PKQRKSIFDPNTFKRPQTPPKIDYLLPGPGPAHSPQPSKRAGPLTPPKPPRRSDSIKFQH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PKQRKSIFDPNTFKRPQTPPKIDYLLPGPGPAHSPQPSKRAGPLTPPKPPRRSDSIKFQH
       910       920       930       940       950       960       

       1030      1040      1050      1060      1070      1080      
pF1KA0 RLETSSESEATLVGSSPSTSPPSALPPDVDPGEPMHASPPRKARVRIASSYYPEGDGDSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLETSSESEATLVGSSPSTSPPSALPPDVDPGEPMHASPPRKARVRIASSYYPEGDGDSS
       970       980       990      1000      1010      1020       

       1090      1100      1110      1120      1130      1140      
pF1KA0 HLPAKKSCDEDLTSQKVDELGQKRRRPKSAPSFRPKLAPVVIPAQFLEEQKCVPASGELS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HLPAKKSCDEDLTSQKVDELGQKRRRPKSAPSFRPKLAPVVIPAQFLEEQKCVPASGELS
      1030      1040      1050      1060      1070      1080       

       1150      1160      1170      1180      1190      1200      
pF1KA0 PELQEWAPYSPGHSSRHSNPPLYPSRPSVGTVPRSLTPSTTVSSILRNPIYTVRSHRVGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PELQEWAPYSPGHSSRHSNPPLYPSRPSVGTVPRSLTPSTTVSSILRNPIYTVRSHRVGP
      1090      1100      1110      1120      1130      1140       

       1210      1220      1230      1240      1250      1260      
pF1KA0 CSSPPAARDAGPQGLHPSVQHQGRLSLDLSHRTCSDYSEMRATHGSNSLPSSARLGSSSN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CSSPPAARDAGPQGLHPSVQHQGRLSLDLSHRTCSDYSEMRATHGSNSLPSSARLGSSSN
      1150      1160      1170      1180      1190      1200       

       1270      1280      1290      1300      1310      1320      
pF1KA0 LQFKAERIKIPSTPRYPRSVVGSERGSVSHSECSTPPQSPLNIDTLSSCSQSQTSASTLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQFKAERIKIPSTPRYPRSVVGSERGSVSHSECSTPPQSPLNIDTLSSCSQSQTSASTLP
      1210      1220      1230      1240      1250      1260       

       1330      1340      1350      1360      1370      1380      
pF1KA0 RIAVNPASLGERRKDRPYVEEPRHVKVQKGSEPLGISIVSGEKGGIYVSKVTVGSIAHQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RIAVNPASLGERRKDRPYVEEPRHVKVQKGSEPLGISIVSGEKGGIYVSKVTVGSIAHQA
      1270      1280      1290      1300      1310      1320       

       1390      1400      1410      1420      1430      1440      
pF1KA0 GLEYGDQLLEFNGINLRSATEQQARLIIGQQCDTITILAQYNPHVHQLSSHSRSSSHLDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLEYGDQLLEFNGINLRSATEQQARLIIGQQCDTITILAQYNPHVHQLSSHSRSSSHLDP
      1330      1340      1350      1360      1370      1380       

       1450      1460      1470      1480      1490      1500      
pF1KA0 AGTHSTLQGSGTTTPEHPSVIDPLMEQDEGPSTPPAKQSSSRIAGDANKKTLEPRVVFIK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGTHSTLQGSGTTTPEHPSVIDPLMEQDEGPSTPPAKQSSSRIAGDANKKTLEPRVVFIK
      1390      1400      1410      1420      1430      1440       

       1510      1520      1530      1540      1550      1560      
pF1KA0 KSQLELGVHLCGGNLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVRNKTVEEVYVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KSQLELGVHLCGGNLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVRNKTVEEVYVE
      1450      1460      1470      1480      1490      1500       

       1570      1580      1590      1600      1610      1620      
pF1KA0 MLKPRDGVRLKVQYRPEEFTKAKGLPGDSFYIRALYDRLADVEQELSFKKDDILYVDDTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MLKPRDGVRLKVQYRPEEFTKAKGLPGDSFYIRALYDRLADVEQELSFKKDDILYVDDTL
      1510      1520      1530      1540      1550      1560       

       1630      1640      1650      1660      1670      1680      
pF1KA0 PQGTFGSWMAWQLDENAQKIQRGQIPSKYVMDQEFSRRLSMSEVKDDNSATKTLSAAARR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PQGTFGSWMAWQLDENAQKIQRGQIPSKYVMDQEFSRRLSMSEVKDDNSATKTLSAAARR
      1570      1580      1590      1600      1610      1620       

       1690      1700      1710      1720      1730      1740      
pF1KA0 SFFRRKHKHKRSGSKDGKDLLALDAFSSDSIPLFEDSVSLAYQRVQKVDCTALRPVLILG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SFFRRKHKHKRSGSKDGKDLLALDAFSSDSIPLFEDSVSLAYQRVQKVDCTALRPVLILG
      1630      1640      1650      1660      1670      1680       

       1750      1760      1770      1780      1790      1800      
pF1KA0 PLLDVVKEMLVNEAPGKFCRCPLEVMKASQQAIERGVKDCLFVDYKRRSGHFDVTTVASI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLLDVVKEMLVNEAPGKFCRCPLEVMKASQQAIERGVKDCLFVDYKRRSGHFDVTTVASI
      1690      1700      1710      1720      1730      1740       

       1810      1820      1830      1840      1850      1860      
pF1KA0 KEITEKNRHCLLDIAPHAIERLHHMHIYPIVIFIHYKSAKHIKEQRDPIYLRDKVTQRHS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEITEKNRHCLLDIAPHAIERLHHMHIYPIVIFIHYKSAKHIKEQRDPIYLRDKVTQRHS
      1750      1760      1770      1780      1790      1800       

       1870      1880      1890      1900      1910         
pF1KA0 KEQFEAAQKLEQEYSRYFTGVIQGGALSSICTQILAMVNQEQNKVLWIPACPL
       :::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEQFEAAQKLEQEYSRYFTGVIQGGALSSICTQILAMVNQEQNKVLWIPACPL
      1810      1820      1830      1840      1850      1860

>>XP_011538644 (OMIM: 604090) PREDICTED: disks large hom  (1829 aa)
 initn: 12018 init1: 12018 opt: 12018  Z-score: 5097.0  bits: 956.4 E(85289):    0
Smith-Waterman score: 12018; 99.8% identity (99.9% similar) in 1822 aa overlap (98-1919:8-1829)

        70        80        90       100       110       120       
pF1KA0 FQDLRAALEKTQPHLLPILYLNGVVGPPQPAEGAGSTYSVLSTMPSDSESSSSLSSVGTT
                                     : ..::::::::::::::::::::::::::
XP_011                        MSWWTECAVSTGSTYSVLSTMPSDSESSSSLSSVGTT
                                      10        20        30       

       130       140       150       160       170       180       
pF1KA0 GKAPSPPPLLTDRQVNEKVENLSIQLRLMTRERNELRKRLAFATHGTAFDKRPYHRLNPD
       ::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GKAPSPPPLLTDQQVNEKVENLSIQLRLMTRERNELRKRLAFATHGTAFDKRPYHRLNPD
        40        50        60        70        80        90       

       190       200       210       220       230       240       
pF1KA0 YERLKIQCVRAMSDLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLSDQTRLKDDVDML
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YERLKIQCVRAMSDLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLSDQTRLKDDVDML
       100       110       120       130       140       150       

       250       260       270       280       290       300       
pF1KA0 RRENGQLLRERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSSEILNKLYDTAM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RRENGQLLRERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSSEILNKLYDTAM
       160       170       180       190       200       210       

       310       320       330       340       350       360       
pF1KA0 DKLEVVKKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRDTAIQLQH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DKLEVVKKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRDTAIQLQH
       220       230       240       250       260       270       

       370       380       390       400       410       420       
pF1KA0 QCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEKYREERDA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEKYREERDA
       280       290       300       310       320       330       

       430       440       450       460       470       480       
pF1KA0 VYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAANEEMEALRQIKDTVTMD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAANEEMEALRQIKDTVTMD
       340       350       360       370       380       390       

       490       500       510       520       530       540       
pF1KA0 AGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERDSIRTLCDNL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERDSIRTLCDNL
       400       410       420       430       440       450       

       550       560       570       580       590       600       
pF1KA0 RRERDRAVSELAEALRSLDDTRKQKNDVSRELKELKEQMESQLEKEARFRQLMAHSSHDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RRERDRAVSELAEALRSLDDTRKQKNDVSRELKELKEQMESQLEKEARFRQLMAHSSHDS
       460       470       480       490       500       510       

       610       620       630       640       650       660       
pF1KA0 AIDTDSMEWETEVVEFERETEDIDLKALGFDMAEGVNEPCFPGDCGIFVTKVDKGSIADG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AIDTDSMEWETEVVEFERETEDIDLKALGFDMAEGVNEPCFPGDCGIFVTKVDKGSIADG
       520       530       540       550       560       570       

       670       680       690       700       710       720       
pF1KA0 RLRVNDWLLRINDVDLINKDKKQAIKALLNGEGAINMVVRRRKSLGGKVVTPLHINLSGQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLRVNDWLLRINDVDLINKDKKQAIKALLNGEGAINMVVRRRKSLGGKVVTPLHINLSGQ
       580       590       600       610       620       630       

       730       740       750       760       770       780       
pF1KA0 KDSGISLENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESLLRSCQDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDSGISLENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESLLRSCQDS
       640       650       660       670       680       690       

       790       800       810       820       830       840       
pF1KA0 LTLSLLKVFPQSSSWSGQNIFENIKDSDKMLSFRAHGPEVQAHNKRNLIQHNNSTQTDIF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LTLSLLKVFPQSSSWSGQNIFENIKDSDKMLSFRAHGPEVQAHNKRNLIQHNNSTQTDIF
       700       710       720       730       740       750       

       850       860       870       880       890       900       
pF1KA0 YTDRLEDRKEPGPPGGSSSFLHKPFPGGPLQVCPQACPSASERSLSSFRSDASGDRGFGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YTDRLEDRKEPGPPGGSSSFLHKPFPGGPLQVCPQACPSASERSLSSFRSDASGDRGFGL
       760       770       780       790       800       810       

       910       920       930       940       950       960       
pF1KA0 VDVRGRRPLLPFETEVGPCGVGEASLDKADSEGSNSGGTWPKAMLSSTAVPEKLSVYKKP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VDVRGRRPLLPFETEVGPCGVGEASLDKADSEGSNSGGTWPKAMLSSTAVPEKLSVYKKP
       820       830       840       850       860       870       

       970       980       990      1000      1010      1020       
pF1KA0 KQRKSIFDPNTFKRPQTPPKIDYLLPGPGPAHSPQPSKRAGPLTPPKPPRRSDSIKFQHR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KQRKSIFDPNTFKRPQTPPKIDYLLPGPGPAHSPQPSKRAGPLTPPKPPRRSDSIKFQHR
       880       890       900       910       920       930       

      1030      1040      1050      1060      1070      1080       
pF1KA0 LETSSESEATLVGSSPSTSPPSALPPDVDPGEPMHASPPRKARVRIASSYYPEGDGDSSH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LETSSESEATLVGSSPSTSPPSALPPDVDPGEPMHASPPRKARVRIASSYYPEGDGDSSH
       940       950       960       970       980       990       

      1090      1100      1110      1120      1130      1140       
pF1KA0 LPAKKSCDEDLTSQKVDELGQKRRRPKSAPSFRPKLAPVVIPAQFLEEQKCVPASGELSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LPAKKSCDEDLTSQKVDELGQKRRRPKSAPSFRPKLAPVVIPAQFLEEQKCVPASGELSP
      1000      1010      1020      1030      1040      1050       

      1150      1160      1170      1180      1190      1200       
pF1KA0 ELQEWAPYSPGHSSRHSNPPLYPSRPSVGTVPRSLTPSTTVSSILRNPIYTVRSHRVGPC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELQEWAPYSPGHSSRHSNPPLYPSRPSVGTVPRSLTPSTTVSSILRNPIYTVRSHRVGPC
      1060      1070      1080      1090      1100      1110       

      1210      1220      1230      1240      1250      1260       
pF1KA0 SSPPAARDAGPQGLHPSVQHQGRLSLDLSHRTCSDYSEMRATHGSNSLPSSARLGSSSNL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSPPAARDAGPQGLHPSVQHQGRLSLDLSHRTCSDYSEMRATHGSNSLPSSARLGSSSNL
      1120      1130      1140      1150      1160      1170       

      1270      1280      1290      1300      1310      1320       
pF1KA0 QFKAERIKIPSTPRYPRSVVGSERGSVSHSECSTPPQSPLNIDTLSSCSQSQTSASTLPR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QFKAERIKIPSTPRYPRSVVGSERGSVSHSECSTPPQSPLNIDTLSSCSQSQTSASTLPR
      1180      1190      1200      1210      1220      1230       

      1330      1340      1350      1360      1370      1380       
pF1KA0 IAVNPASLGERRKDRPYVEEPRHVKVQKGSEPLGISIVSGEKGGIYVSKVTVGSIAHQAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IAVNPASLGERRKDRPYVEEPRHVKVQKGSEPLGISIVSGEKGGIYVSKVTVGSIAHQAG
      1240      1250      1260      1270      1280      1290       

      1390      1400      1410      1420      1430      1440       
pF1KA0 LEYGDQLLEFNGINLRSATEQQARLIIGQQCDTITILAQYNPHVHQLSSHSRSSSHLDPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEYGDQLLEFNGINLRSATEQQARLIIGQQCDTITILAQYNPHVHQLSSHSRSSSHLDPA
      1300      1310      1320      1330      1340      1350       

      1450      1460      1470      1480      1490      1500       
pF1KA0 GTHSTLQGSGTTTPEHPSVIDPLMEQDEGPSTPPAKQSSSRIAGDANKKTLEPRVVFIKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GTHSTLQGSGTTTPEHPSVIDPLMEQDEGPSTPPAKQSSSRIAGDANKKTLEPRVVFIKK
      1360      1370      1380      1390      1400      1410       

      1510      1520      1530      1540      1550      1560       
pF1KA0 SQLELGVHLCGGNLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVRNKTVEEVYVEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQLELGVHLCGGNLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVRNKTVEEVYVEM
      1420      1430      1440      1450      1460      1470       

      1570      1580      1590      1600      1610      1620       
pF1KA0 LKPRDGVRLKVQYRPEEFTKAKGLPGDSFYIRALYDRLADVEQELSFKKDDILYVDDTLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKPRDGVRLKVQYRPEEFTKAKGLPGDSFYIRALYDRLADVEQELSFKKDDILYVDDTLP
      1480      1490      1500      1510      1520      1530       

      1630      1640      1650      1660      1670      1680       
pF1KA0 QGTFGSWMAWQLDENAQKIQRGQIPSKYVMDQEFSRRLSMSEVKDDNSATKTLSAAARRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QGTFGSWMAWQLDENAQKIQRGQIPSKYVMDQEFSRRLSMSEVKDDNSATKTLSAAARRS
      1540      1550      1560      1570      1580      1590       

      1690      1700      1710      1720      1730      1740       
pF1KA0 FFRRKHKHKRSGSKDGKDLLALDAFSSDSIPLFEDSVSLAYQRVQKVDCTALRPVLILGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FFRRKHKHKRSGSKDGKDLLALDAFSSDSIPLFEDSVSLAYQRVQKVDCTALRPVLILGP
      1600      1610      1620      1630      1640      1650       

      1750      1760      1770      1780      1790      1800       
pF1KA0 LLDVVKEMLVNEAPGKFCRCPLEVMKASQQAIERGVKDCLFVDYKRRSGHFDVTTVASIK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLDVVKEMLVNEAPGKFCRCPLEVMKASQQAIERGVKDCLFVDYKRRSGHFDVTTVASIK
      1660      1670      1680      1690      1700      1710       

      1810      1820      1830      1840      1850      1860       
pF1KA0 EITEKNRHCLLDIAPHAIERLHHMHIYPIVIFIHYKSAKHIKEQRDPIYLRDKVTQRHSK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EITEKNRHCLLDIAPHAIERLHHMHIYPIVIFIHYKSAKHIKEQRDPIYLRDKVTQRHSK
      1720      1730      1740      1750      1760      1770       

      1870      1880      1890      1900      1910         
pF1KA0 EQFEAAQKLEQEYSRYFTGVIQGGALSSICTQILAMVNQEQNKVLWIPACPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EQFEAAQKLEQEYSRYFTGVIQGGALSSICTQILAMVNQEQNKVLWIPACPL
      1780      1790      1800      1810      1820         

>>XP_016872402 (OMIM: 604090) PREDICTED: disks large hom  (1825 aa)
 initn: 12016 init1: 12016 opt: 12016  Z-score: 5096.1  bits: 956.3 E(85289):    0
Smith-Waterman score: 12016; 99.9% identity (100.0% similar) in 1818 aa overlap (102-1919:8-1825)

              80        90       100       110       120       130 
pF1KA0 RAALEKTQPHLLPILYLNGVVGPPQPAEGAGSTYSVLSTMPSDSESSSSLSSVGTTGKAP
                                     ::::::::::::::::::::::::::::::
XP_016                        MGTYIELGSTYSVLSTMPSDSESSSSLSSVGTTGKAP
                                      10        20        30       

             140       150       160       170       180       190 
pF1KA0 SPPPLLTDRQVNEKVENLSIQLRLMTRERNELRKRLAFATHGTAFDKRPYHRLNPDYERL
       ::::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPPPLLTDQQVNEKVENLSIQLRLMTRERNELRKRLAFATHGTAFDKRPYHRLNPDYERL
        40        50        60        70        80        90       

             200       210       220       230       240       250 
pF1KA0 KIQCVRAMSDLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLSDQTRLKDDVDMLRREN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KIQCVRAMSDLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLSDQTRLKDDVDMLRREN
       100       110       120       130       140       150       

             260       270       280       290       300       310 
pF1KA0 GQLLRERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSSEILNKLYDTAMDKLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GQLLRERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSSEILNKLYDTAMDKLE
       160       170       180       190       200       210       

             320       330       340       350       360       370 
pF1KA0 VVKKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRDTAIQLQHQCAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VVKKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRDTAIQLQHQCAL
       220       230       240       250       260       270       

             380       390       400       410       420       430 
pF1KA0 SLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEKYREERDAVYSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEKYREERDAVYSE
       280       290       300       310       320       330       

             440       450       460       470       480       490 
pF1KA0 YKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAANEEMEALRQIKDTVTMDAGRA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAANEEMEALRQIKDTVTMDAGRA
       340       350       360       370       380       390       

             500       510       520       530       540       550 
pF1KA0 NKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERDSIRTLCDNLRRER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERDSIRTLCDNLRRER
       400       410       420       430       440       450       

             560       570       580       590       600       610 
pF1KA0 DRAVSELAEALRSLDDTRKQKNDVSRELKELKEQMESQLEKEARFRQLMAHSSHDSAIDT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DRAVSELAEALRSLDDTRKQKNDVSRELKELKEQMESQLEKEARFRQLMAHSSHDSAIDT
       460       470       480       490       500       510       

             620       630       640       650       660       670 
pF1KA0 DSMEWETEVVEFERETEDIDLKALGFDMAEGVNEPCFPGDCGIFVTKVDKGSIADGRLRV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSMEWETEVVEFERETEDIDLKALGFDMAEGVNEPCFPGDCGIFVTKVDKGSIADGRLRV
       520       530       540       550       560       570       

             680       690       700       710       720       730 
pF1KA0 NDWLLRINDVDLINKDKKQAIKALLNGEGAINMVVRRRKSLGGKVVTPLHINLSGQKDSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NDWLLRINDVDLINKDKKQAIKALLNGEGAINMVVRRRKSLGGKVVTPLHINLSGQKDSG
       580       590       600       610       620       630       

             740       750       760       770       780       790 
pF1KA0 ISLENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESLLRSCQDSLTLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ISLENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESLLRSCQDSLTLS
       640       650       660       670       680       690       

             800       810       820       830       840       850 
pF1KA0 LLKVFPQSSSWSGQNIFENIKDSDKMLSFRAHGPEVQAHNKRNLIQHNNSTQTDIFYTDR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLKVFPQSSSWSGQNIFENIKDSDKMLSFRAHGPEVQAHNKRNLIQHNNSTQTDIFYTDR
       700       710       720       730       740       750       

             860       870       880       890       900       910 
pF1KA0 LEDRKEPGPPGGSSSFLHKPFPGGPLQVCPQACPSASERSLSSFRSDASGDRGFGLVDVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEDRKEPGPPGGSSSFLHKPFPGGPLQVCPQACPSASERSLSSFRSDASGDRGFGLVDVR
       760       770       780       790       800       810       

             920       930       940       950       960       970 
pF1KA0 GRRPLLPFETEVGPCGVGEASLDKADSEGSNSGGTWPKAMLSSTAVPEKLSVYKKPKQRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRRPLLPFETEVGPCGVGEASLDKADSEGSNSGGTWPKAMLSSTAVPEKLSVYKKPKQRK
       820       830       840       850       860       870       

             980       990      1000      1010      1020      1030 
pF1KA0 SIFDPNTFKRPQTPPKIDYLLPGPGPAHSPQPSKRAGPLTPPKPPRRSDSIKFQHRLETS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SIFDPNTFKRPQTPPKIDYLLPGPGPAHSPQPSKRAGPLTPPKPPRRSDSIKFQHRLETS
       880       890       900       910       920       930       

            1040      1050      1060      1070      1080      1090 
pF1KA0 SESEATLVGSSPSTSPPSALPPDVDPGEPMHASPPRKARVRIASSYYPEGDGDSSHLPAK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SESEATLVGSSPSTSPPSALPPDVDPGEPMHASPPRKARVRIASSYYPEGDGDSSHLPAK
       940       950       960       970       980       990       

            1100      1110      1120      1130      1140      1150 
pF1KA0 KSCDEDLTSQKVDELGQKRRRPKSAPSFRPKLAPVVIPAQFLEEQKCVPASGELSPELQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSCDEDLTSQKVDELGQKRRRPKSAPSFRPKLAPVVIPAQFLEEQKCVPASGELSPELQE
      1000      1010      1020      1030      1040      1050       

            1160      1170      1180      1190      1200      1210 
pF1KA0 WAPYSPGHSSRHSNPPLYPSRPSVGTVPRSLTPSTTVSSILRNPIYTVRSHRVGPCSSPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WAPYSPGHSSRHSNPPLYPSRPSVGTVPRSLTPSTTVSSILRNPIYTVRSHRVGPCSSPP
      1060      1070      1080      1090      1100      1110       

            1220      1230      1240      1250      1260      1270 
pF1KA0 AARDAGPQGLHPSVQHQGRLSLDLSHRTCSDYSEMRATHGSNSLPSSARLGSSSNLQFKA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AARDAGPQGLHPSVQHQGRLSLDLSHRTCSDYSEMRATHGSNSLPSSARLGSSSNLQFKA
      1120      1130      1140      1150      1160      1170       

            1280      1290      1300      1310      1320      1330 
pF1KA0 ERIKIPSTPRYPRSVVGSERGSVSHSECSTPPQSPLNIDTLSSCSQSQTSASTLPRIAVN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ERIKIPSTPRYPRSVVGSERGSVSHSECSTPPQSPLNIDTLSSCSQSQTSASTLPRIAVN
      1180      1190      1200      1210      1220      1230       

            1340      1350      1360      1370      1380      1390 
pF1KA0 PASLGERRKDRPYVEEPRHVKVQKGSEPLGISIVSGEKGGIYVSKVTVGSIAHQAGLEYG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PASLGERRKDRPYVEEPRHVKVQKGSEPLGISIVSGEKGGIYVSKVTVGSIAHQAGLEYG
      1240      1250      1260      1270      1280      1290       

            1400      1410      1420      1430      1440      1450 
pF1KA0 DQLLEFNGINLRSATEQQARLIIGQQCDTITILAQYNPHVHQLSSHSRSSSHLDPAGTHS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DQLLEFNGINLRSATEQQARLIIGQQCDTITILAQYNPHVHQLSSHSRSSSHLDPAGTHS
      1300      1310      1320      1330      1340      1350       

            1460      1470      1480      1490      1500      1510 
pF1KA0 TLQGSGTTTPEHPSVIDPLMEQDEGPSTPPAKQSSSRIAGDANKKTLEPRVVFIKKSQLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLQGSGTTTPEHPSVIDPLMEQDEGPSTPPAKQSSSRIAGDANKKTLEPRVVFIKKSQLE
      1360      1370      1380      1390      1400      1410       

            1520      1530      1540      1550      1560      1570 
pF1KA0 LGVHLCGGNLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVRNKTVEEVYVEMLKPR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGVHLCGGNLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVRNKTVEEVYVEMLKPR
      1420      1430      1440      1450      1460      1470       

            1580      1590      1600      1610      1620      1630 
pF1KA0 DGVRLKVQYRPEEFTKAKGLPGDSFYIRALYDRLADVEQELSFKKDDILYVDDTLPQGTF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DGVRLKVQYRPEEFTKAKGLPGDSFYIRALYDRLADVEQELSFKKDDILYVDDTLPQGTF
      1480      1490      1500      1510      1520      1530       

            1640      1650      1660      1670      1680      1690 
pF1KA0 GSWMAWQLDENAQKIQRGQIPSKYVMDQEFSRRLSMSEVKDDNSATKTLSAAARRSFFRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSWMAWQLDENAQKIQRGQIPSKYVMDQEFSRRLSMSEVKDDNSATKTLSAAARRSFFRR
      1540      1550      1560      1570      1580      1590       

            1700      1710      1720      1730      1740      1750 
pF1KA0 KHKHKRSGSKDGKDLLALDAFSSDSIPLFEDSVSLAYQRVQKVDCTALRPVLILGPLLDV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KHKHKRSGSKDGKDLLALDAFSSDSIPLFEDSVSLAYQRVQKVDCTALRPVLILGPLLDV
      1600      1610      1620      1630      1640      1650       

            1760      1770      1780      1790      1800      1810 
pF1KA0 VKEMLVNEAPGKFCRCPLEVMKASQQAIERGVKDCLFVDYKRRSGHFDVTTVASIKEITE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKEMLVNEAPGKFCRCPLEVMKASQQAIERGVKDCLFVDYKRRSGHFDVTTVASIKEITE
      1660      1670      1680      1690      1700      1710       

            1820      1830      1840      1850      1860      1870 
pF1KA0 KNRHCLLDIAPHAIERLHHMHIYPIVIFIHYKSAKHIKEQRDPIYLRDKVTQRHSKEQFE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KNRHCLLDIAPHAIERLHHMHIYPIVIFIHYKSAKHIKEQRDPIYLRDKVTQRHSKEQFE
      1720      1730      1740      1750      1760      1770       

            1880      1890      1900      1910         
pF1KA0 AAQKLEQEYSRYFTGVIQGGALSSICTQILAMVNQEQNKVLWIPACPL
       ::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAQKLEQEYSRYFTGVIQGGALSSICTQILAMVNQEQNKVLWIPACPL
      1780      1790      1800      1810      1820     

>>XP_016872403 (OMIM: 604090) PREDICTED: disks large hom  (1809 aa)
 initn: 11965 init1: 11965 opt: 11965  Z-score: 5074.6  bits: 952.3 E(85289):    0
Smith-Waterman score: 11965; 99.9% identity (100.0% similar) in 1809 aa overlap (111-1919:1-1809)

               90       100       110       120       130       140
pF1KA0 HLLPILYLNGVVGPPQPAEGAGSTYSVLSTMPSDSESSSSLSSVGTTGKAPSPPPLLTDR
                                     :::::::::::::::::::::::::::::.
XP_016                               MPSDSESSSSLSSVGTTGKAPSPPPLLTDQ
                                             10        20        30

              150       160       170       180       190       200
pF1KA0 QVNEKVENLSIQLRLMTRERNELRKRLAFATHGTAFDKRPYHRLNPDYERLKIQCVRAMS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QVNEKVENLSIQLRLMTRERNELRKRLAFATHGTAFDKRPYHRLNPDYERLKIQCVRAMS
               40        50        60        70        80        90

              210       220       230       240       250       260
pF1KA0 DLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLSDQTRLKDDVDMLRRENGQLLRERNL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLSDQTRLKDDVDMLRRENGQLLRERNL
              100       110       120       130       140       150

              270       280       290       300       310       320
pF1KA0 LQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSSEILNKLYDTAMDKLEVVKKDYDAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSSEILNKLYDTAMDKLEVVKKDYDAL
              160       170       180       190       200       210

              330       340       350       360       370       380
pF1KA0 RKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRDTAIQLQHQCALSLRRFEAIH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRDTAIQLQHQCALSLRRFEAIH
              220       230       240       250       260       270

              390       400       410       420       430       440
pF1KA0 HELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEKYREERDAVYSEYKLIMSERD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEKYREERDAVYSEYKLIMSERD
              280       290       300       310       320       330

              450       460       470       480       490       500
pF1KA0 QVISELDKLQTEVELAESKLKSSTSEKKAANEEMEALRQIKDTVTMDAGRANKEVEILRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QVISELDKLQTEVELAESKLKSSTSEKKAANEEMEALRQIKDTVTMDAGRANKEVEILRK
              340       350       360       370       380       390

              510       520       530       540       550       560
pF1KA0 QCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERDSIRTLCDNLRRERDRAVSELAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERDSIRTLCDNLRRERDRAVSELAE
              400       410       420       430       440       450

              570       580       590       600       610       620
pF1KA0 ALRSLDDTRKQKNDVSRELKELKEQMESQLEKEARFRQLMAHSSHDSAIDTDSMEWETEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALRSLDDTRKQKNDVSRELKELKEQMESQLEKEARFRQLMAHSSHDSAIDTDSMEWETEV
              460       470       480       490       500       510

              630       640       650       660       670       680
pF1KA0 VEFERETEDIDLKALGFDMAEGVNEPCFPGDCGIFVTKVDKGSIADGRLRVNDWLLRIND
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VEFERETEDIDLKALGFDMAEGVNEPCFPGDCGIFVTKVDKGSIADGRLRVNDWLLRIND
              520       530       540       550       560       570

              690       700       710       720       730       740
pF1KA0 VDLINKDKKQAIKALLNGEGAINMVVRRRKSLGGKVVTPLHINLSGQKDSGISLENGVYA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VDLINKDKKQAIKALLNGEGAINMVVRRRKSLGGKVVTPLHINLSGQKDSGISLENGVYA
              580       590       600       610       620       630

              750       760       770       780       790       800
pF1KA0 AAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESLLRSCQDSLTLSLLKVFPQSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESLLRSCQDSLTLSLLKVFPQSS
              640       650       660       670       680       690

              810       820       830       840       850       860
pF1KA0 SWSGQNIFENIKDSDKMLSFRAHGPEVQAHNKRNLIQHNNSTQTDIFYTDRLEDRKEPGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SWSGQNIFENIKDSDKMLSFRAHGPEVQAHNKRNLIQHNNSTQTDIFYTDRLEDRKEPGP
              700       710       720       730       740       750

              870       880       890       900       910       920
pF1KA0 PGGSSSFLHKPFPGGPLQVCPQACPSASERSLSSFRSDASGDRGFGLVDVRGRRPLLPFE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGGSSSFLHKPFPGGPLQVCPQACPSASERSLSSFRSDASGDRGFGLVDVRGRRPLLPFE
              760       770       780       790       800       810

              930       940       950       960       970       980
pF1KA0 TEVGPCGVGEASLDKADSEGSNSGGTWPKAMLSSTAVPEKLSVYKKPKQRKSIFDPNTFK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TEVGPCGVGEASLDKADSEGSNSGGTWPKAMLSSTAVPEKLSVYKKPKQRKSIFDPNTFK
              820       830       840       850       860       870

              990      1000      1010      1020      1030      1040
pF1KA0 RPQTPPKIDYLLPGPGPAHSPQPSKRAGPLTPPKPPRRSDSIKFQHRLETSSESEATLVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPQTPPKIDYLLPGPGPAHSPQPSKRAGPLTPPKPPRRSDSIKFQHRLETSSESEATLVG
              880       890       900       910       920       930

             1050      1060      1070      1080      1090      1100
pF1KA0 SSPSTSPPSALPPDVDPGEPMHASPPRKARVRIASSYYPEGDGDSSHLPAKKSCDEDLTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSPSTSPPSALPPDVDPGEPMHASPPRKARVRIASSYYPEGDGDSSHLPAKKSCDEDLTS
              940       950       960       970       980       990

             1110      1120      1130      1140      1150      1160
pF1KA0 QKVDELGQKRRRPKSAPSFRPKLAPVVIPAQFLEEQKCVPASGELSPELQEWAPYSPGHS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QKVDELGQKRRRPKSAPSFRPKLAPVVIPAQFLEEQKCVPASGELSPELQEWAPYSPGHS
             1000      1010      1020      1030      1040      1050

             1170      1180      1190      1200      1210      1220
pF1KA0 SRHSNPPLYPSRPSVGTVPRSLTPSTTVSSILRNPIYTVRSHRVGPCSSPPAARDAGPQG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SRHSNPPLYPSRPSVGTVPRSLTPSTTVSSILRNPIYTVRSHRVGPCSSPPAARDAGPQG
             1060      1070      1080      1090      1100      1110

             1230      1240      1250      1260      1270      1280
pF1KA0 LHPSVQHQGRLSLDLSHRTCSDYSEMRATHGSNSLPSSARLGSSSNLQFKAERIKIPSTP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LHPSVQHQGRLSLDLSHRTCSDYSEMRATHGSNSLPSSARLGSSSNLQFKAERIKIPSTP
             1120      1130      1140      1150      1160      1170

             1290      1300      1310      1320      1330      1340
pF1KA0 RYPRSVVGSERGSVSHSECSTPPQSPLNIDTLSSCSQSQTSASTLPRIAVNPASLGERRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RYPRSVVGSERGSVSHSECSTPPQSPLNIDTLSSCSQSQTSASTLPRIAVNPASLGERRK
             1180      1190      1200      1210      1220      1230

             1350      1360      1370      1380      1390      1400
pF1KA0 DRPYVEEPRHVKVQKGSEPLGISIVSGEKGGIYVSKVTVGSIAHQAGLEYGDQLLEFNGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DRPYVEEPRHVKVQKGSEPLGISIVSGEKGGIYVSKVTVGSIAHQAGLEYGDQLLEFNGI
             1240      1250      1260      1270      1280      1290

             1410      1420      1430      1440      1450      1460
pF1KA0 NLRSATEQQARLIIGQQCDTITILAQYNPHVHQLSSHSRSSSHLDPAGTHSTLQGSGTTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NLRSATEQQARLIIGQQCDTITILAQYNPHVHQLSSHSRSSSHLDPAGTHSTLQGSGTTT
             1300      1310      1320      1330      1340      1350

             1470      1480      1490      1500      1510      1520
pF1KA0 PEHPSVIDPLMEQDEGPSTPPAKQSSSRIAGDANKKTLEPRVVFIKKSQLELGVHLCGGN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PEHPSVIDPLMEQDEGPSTPPAKQSSSRIAGDANKKTLEPRVVFIKKSQLELGVHLCGGN
             1360      1370      1380      1390      1400      1410

             1530      1540      1550      1560      1570      1580
pF1KA0 LHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVRNKTVEEVYVEMLKPRDGVRLKVQY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVRNKTVEEVYVEMLKPRDGVRLKVQY
             1420      1430      1440      1450      1460      1470

             1590      1600      1610      1620      1630      1640
pF1KA0 RPEEFTKAKGLPGDSFYIRALYDRLADVEQELSFKKDDILYVDDTLPQGTFGSWMAWQLD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPEEFTKAKGLPGDSFYIRALYDRLADVEQELSFKKDDILYVDDTLPQGTFGSWMAWQLD
             1480      1490      1500      1510      1520      1530

             1650      1660      1670      1680      1690      1700
pF1KA0 ENAQKIQRGQIPSKYVMDQEFSRRLSMSEVKDDNSATKTLSAAARRSFFRRKHKHKRSGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ENAQKIQRGQIPSKYVMDQEFSRRLSMSEVKDDNSATKTLSAAARRSFFRRKHKHKRSGS
             1540      1550      1560      1570      1580      1590

             1710      1720      1730      1740      1750      1760
pF1KA0 KDGKDLLALDAFSSDSIPLFEDSVSLAYQRVQKVDCTALRPVLILGPLLDVVKEMLVNEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KDGKDLLALDAFSSDSIPLFEDSVSLAYQRVQKVDCTALRPVLILGPLLDVVKEMLVNEA
             1600      1610      1620      1630      1640      1650

             1770      1780      1790      1800      1810      1820
pF1KA0 PGKFCRCPLEVMKASQQAIERGVKDCLFVDYKRRSGHFDVTTVASIKEITEKNRHCLLDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGKFCRCPLEVMKASQQAIERGVKDCLFVDYKRRSGHFDVTTVASIKEITEKNRHCLLDI
             1660      1670      1680      1690      1700      1710

             1830      1840      1850      1860      1870      1880
pF1KA0 APHAIERLHHMHIYPIVIFIHYKSAKHIKEQRDPIYLRDKVTQRHSKEQFEAAQKLEQEY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APHAIERLHHMHIYPIVIFIHYKSAKHIKEQRDPIYLRDKVTQRHSKEQFEAAQKLEQEY
             1720      1730      1740      1750      1760      1770

             1890      1900      1910         
pF1KA0 SRYFTGVIQGGALSSICTQILAMVNQEQNKVLWIPACPL
       :::::::::::::::::::::::::::::::::::::::
XP_016 SRYFTGVIQGGALSSICTQILAMVNQEQNKVLWIPACPL
             1780      1790      1800         

>>XP_011538646 (OMIM: 604090) PREDICTED: disks large hom  (1807 aa)
 initn: 11884 init1: 11884 opt: 11884  Z-score: 5040.4  bits: 946.0 E(85289):    0
Smith-Waterman score: 11884; 99.9% identity (100.0% similar) in 1795 aa overlap (125-1919:13-1807)

          100       110       120       130       140       150    
pF1KA0 PQPAEGAGSTYSVLSTMPSDSESSSSLSSVGTTGKAPSPPPLLTDRQVNEKVENLSIQLR
                                     :::::::::::::::.::::::::::::::
XP_011                   MQGSRPKQSHPGGTTGKAPSPPPLLTDQQVNEKVENLSIQLR
                                 10        20        30        40  

          160       170       180       190       200       210    
pF1KA0 LMTRERNELRKRLAFATHGTAFDKRPYHRLNPDYERLKIQCVRAMSDLQSLQNQHTNALK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LMTRERNELRKRLAFATHGTAFDKRPYHRLNPDYERLKIQCVRAMSDLQSLQNQHTNALK
             50        60        70        80        90       100  

          220       230       240       250       260       270    
pF1KA0 RCEEVAKETDFYHTLHSRLLSDQTRLKDDVDMLRRENGQLLRERNLLQQSWEDMKRLHEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RCEEVAKETDFYHTLHSRLLSDQTRLKDDVDMLRRENGQLLRERNLLQQSWEDMKRLHEE
            110       120       130       140       150       160  

          280       290       300       310       320       330    
pF1KA0 DQKEIGDLRAQQQQVLKHNGSSEILNKLYDTAMDKLEVVKKDYDALRKRYSEKVAIHNAD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DQKEIGDLRAQQQQVLKHNGSSEILNKLYDTAMDKLEVVKKDYDALRKRYSEKVAIHNAD
            170       180       190       200       210       220  

          340       350       360       370       380       390    
pF1KA0 LSRLEQLGEENQRLLKQTEMLTQQRDTAIQLQHQCALSLRRFEAIHHELNKATAQNKDLQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSRLEQLGEENQRLLKQTEMLTQQRDTAIQLQHQCALSLRRFEAIHHELNKATAQNKDLQ
            230       240       250       260       270       280  

          400       410       420       430       440       450    
pF1KA0 WEMELLQSELTELRTTQVKTAKESEKYREERDAVYSEYKLIMSERDQVISELDKLQTEVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WEMELLQSELTELRTTQVKTAKESEKYREERDAVYSEYKLIMSERDQVISELDKLQTEVE
            290       300       310       320       330       340  

          460       470       480       490       500       510    
pF1KA0 LAESKLKSSTSEKKAANEEMEALRQIKDTVTMDAGRANKEVEILRKQCKALCQELKEALQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAESKLKSSTSEKKAANEEMEALRQIKDTVTMDAGRANKEVEILRKQCKALCQELKEALQ
            350       360       370       380       390       400  

          520       530       540       550       560       570    
pF1KA0 EADVAKCRRDWAFQERDKIVAERDSIRTLCDNLRRERDRAVSELAEALRSLDDTRKQKND
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EADVAKCRRDWAFQERDKIVAERDSIRTLCDNLRRERDRAVSELAEALRSLDDTRKQKND
            410       420       430       440       450       460  

          580       590       600       610       620       630    
pF1KA0 VSRELKELKEQMESQLEKEARFRQLMAHSSHDSAIDTDSMEWETEVVEFERETEDIDLKA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VSRELKELKEQMESQLEKEARFRQLMAHSSHDSAIDTDSMEWETEVVEFERETEDIDLKA
            470       480       490       500       510       520  

          640       650       660       670       680       690    
pF1KA0 LGFDMAEGVNEPCFPGDCGIFVTKVDKGSIADGRLRVNDWLLRINDVDLINKDKKQAIKA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LGFDMAEGVNEPCFPGDCGIFVTKVDKGSIADGRLRVNDWLLRINDVDLINKDKKQAIKA
            530       540       550       560       570       580  

          700       710       720       730       740       750    
pF1KA0 LLNGEGAINMVVRRRKSLGGKVVTPLHINLSGQKDSGISLENGVYAAAVLPGSPAAKEGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLNGEGAINMVVRRRKSLGGKVVTPLHINLSGQKDSGISLENGVYAAAVLPGSPAAKEGS
            590       600       610       620       630       640  

          760       770       780       790       800       810    
pF1KA0 LAVGDRIVAINGIALDNKSLNECESLLRSCQDSLTLSLLKVFPQSSSWSGQNIFENIKDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAVGDRIVAINGIALDNKSLNECESLLRSCQDSLTLSLLKVFPQSSSWSGQNIFENIKDS
            650       660       670       680       690       700  

          820       830       840       850       860       870    
pF1KA0 DKMLSFRAHGPEVQAHNKRNLIQHNNSTQTDIFYTDRLEDRKEPGPPGGSSSFLHKPFPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DKMLSFRAHGPEVQAHNKRNLIQHNNSTQTDIFYTDRLEDRKEPGPPGGSSSFLHKPFPG
            710       720       730       740       750       760  

          880       890       900       910       920       930    
pF1KA0 GPLQVCPQACPSASERSLSSFRSDASGDRGFGLVDVRGRRPLLPFETEVGPCGVGEASLD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GPLQVCPQACPSASERSLSSFRSDASGDRGFGLVDVRGRRPLLPFETEVGPCGVGEASLD
            770       780       790       800       810       820  

          940       950       960       970       980       990    
pF1KA0 KADSEGSNSGGTWPKAMLSSTAVPEKLSVYKKPKQRKSIFDPNTFKRPQTPPKIDYLLPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KADSEGSNSGGTWPKAMLSSTAVPEKLSVYKKPKQRKSIFDPNTFKRPQTPPKIDYLLPG
            830       840       850       860       870       880  

         1000      1010      1020      1030      1040      1050    
pF1KA0 PGPAHSPQPSKRAGPLTPPKPPRRSDSIKFQHRLETSSESEATLVGSSPSTSPPSALPPD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGPAHSPQPSKRAGPLTPPKPPRRSDSIKFQHRLETSSESEATLVGSSPSTSPPSALPPD
            890       900       910       920       930       940  

         1060      1070      1080      1090      1100      1110    
pF1KA0 VDPGEPMHASPPRKARVRIASSYYPEGDGDSSHLPAKKSCDEDLTSQKVDELGQKRRRPK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VDPGEPMHASPPRKARVRIASSYYPEGDGDSSHLPAKKSCDEDLTSQKVDELGQKRRRPK
            950       960       970       980       990      1000  

         1120      1130      1140      1150      1160      1170    
pF1KA0 SAPSFRPKLAPVVIPAQFLEEQKCVPASGELSPELQEWAPYSPGHSSRHSNPPLYPSRPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SAPSFRPKLAPVVIPAQFLEEQKCVPASGELSPELQEWAPYSPGHSSRHSNPPLYPSRPS
           1010      1020      1030      1040      1050      1060  

         1180      1190      1200      1210      1220      1230    
pF1KA0 VGTVPRSLTPSTTVSSILRNPIYTVRSHRVGPCSSPPAARDAGPQGLHPSVQHQGRLSLD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VGTVPRSLTPSTTVSSILRNPIYTVRSHRVGPCSSPPAARDAGPQGLHPSVQHQGRLSLD
           1070      1080      1090      1100      1110      1120  

         1240      1250      1260      1270      1280      1290    
pF1KA0 LSHRTCSDYSEMRATHGSNSLPSSARLGSSSNLQFKAERIKIPSTPRYPRSVVGSERGSV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSHRTCSDYSEMRATHGSNSLPSSARLGSSSNLQFKAERIKIPSTPRYPRSVVGSERGSV
           1130      1140      1150      1160      1170      1180  

         1300      1310      1320      1330      1340      1350    
pF1KA0 SHSECSTPPQSPLNIDTLSSCSQSQTSASTLPRIAVNPASLGERRKDRPYVEEPRHVKVQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SHSECSTPPQSPLNIDTLSSCSQSQTSASTLPRIAVNPASLGERRKDRPYVEEPRHVKVQ
           1190      1200      1210      1220      1230      1240  

         1360      1370      1380      1390      1400      1410    
pF1KA0 KGSEPLGISIVSGEKGGIYVSKVTVGSIAHQAGLEYGDQLLEFNGINLRSATEQQARLII
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KGSEPLGISIVSGEKGGIYVSKVTVGSIAHQAGLEYGDQLLEFNGINLRSATEQQARLII
           1250      1260      1270      1280      1290      1300  

         1420      1430      1440      1450      1460      1470    
pF1KA0 GQQCDTITILAQYNPHVHQLSSHSRSSSHLDPAGTHSTLQGSGTTTPEHPSVIDPLMEQD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GQQCDTITILAQYNPHVHQLSSHSRSSSHLDPAGTHSTLQGSGTTTPEHPSVIDPLMEQD
           1310      1320      1330      1340      1350      1360  

         1480      1490      1500      1510      1520      1530    
pF1KA0 EGPSTPPAKQSSSRIAGDANKKTLEPRVVFIKKSQLELGVHLCGGNLHGVFVAEVEDDSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EGPSTPPAKQSSSRIAGDANKKTLEPRVVFIKKSQLELGVHLCGGNLHGVFVAEVEDDSP
           1370      1380      1390      1400      1410      1420  

         1540      1550      1560      1570      1580      1590    
pF1KA0 AKGPDGLVPGDLILEYGSLDVRNKTVEEVYVEMLKPRDGVRLKVQYRPEEFTKAKGLPGD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AKGPDGLVPGDLILEYGSLDVRNKTVEEVYVEMLKPRDGVRLKVQYRPEEFTKAKGLPGD
           1430      1440      1450      1460      1470      1480  

         1600      1610      1620      1630      1640      1650    
pF1KA0 SFYIRALYDRLADVEQELSFKKDDILYVDDTLPQGTFGSWMAWQLDENAQKIQRGQIPSK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SFYIRALYDRLADVEQELSFKKDDILYVDDTLPQGTFGSWMAWQLDENAQKIQRGQIPSK
           1490      1500      1510      1520      1530      1540  

         1660      1670      1680      1690      1700      1710    
pF1KA0 YVMDQEFSRRLSMSEVKDDNSATKTLSAAARRSFFRRKHKHKRSGSKDGKDLLALDAFSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YVMDQEFSRRLSMSEVKDDNSATKTLSAAARRSFFRRKHKHKRSGSKDGKDLLALDAFSS
           1550      1560      1570      1580      1590      1600  

         1720      1730      1740      1750      1760      1770    
pF1KA0 DSIPLFEDSVSLAYQRVQKVDCTALRPVLILGPLLDVVKEMLVNEAPGKFCRCPLEVMKA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DSIPLFEDSVSLAYQRVQKVDCTALRPVLILGPLLDVVKEMLVNEAPGKFCRCPLEVMKA
           1610      1620      1630      1640      1650      1660  

         1780      1790      1800      1810      1820      1830    
pF1KA0 SQQAIERGVKDCLFVDYKRRSGHFDVTTVASIKEITEKNRHCLLDIAPHAIERLHHMHIY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQQAIERGVKDCLFVDYKRRSGHFDVTTVASIKEITEKNRHCLLDIAPHAIERLHHMHIY
           1670      1680      1690      1700      1710      1720  

         1840      1850      1860      1870      1880      1890    
pF1KA0 PIVIFIHYKSAKHIKEQRDPIYLRDKVTQRHSKEQFEAAQKLEQEYSRYFTGVIQGGALS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PIVIFIHYKSAKHIKEQRDPIYLRDKVTQRHSKEQFEAAQKLEQEYSRYFTGVIQGGALS
           1730      1740      1750      1760      1770      1780  

         1900      1910         
pF1KA0 SICTQILAMVNQEQNKVLWIPACPL
       :::::::::::::::::::::::::
XP_011 SICTQILAMVNQEQNKVLWIPACPL
           1790      1800       

>>XP_011538647 (OMIM: 604090) PREDICTED: disks large hom  (1764 aa)
 initn: 11690 init1: 11690 opt: 11690  Z-score: 4958.6  bits: 930.8 E(85289):    0
Smith-Waterman score: 11690; 100.0% identity (100.0% similar) in 1764 aa overlap (156-1919:1-1764)

         130       140       150       160       170       180     
pF1KA0 TTGKAPSPPPLLTDRQVNEKVENLSIQLRLMTRERNELRKRLAFATHGTAFDKRPYHRLN
                                     ::::::::::::::::::::::::::::::
XP_011                               MTRERNELRKRLAFATHGTAFDKRPYHRLN
                                             10        20        30

         190       200       210       220       230       240     
pF1KA0 PDYERLKIQCVRAMSDLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLSDQTRLKDDVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PDYERLKIQCVRAMSDLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLSDQTRLKDDVD
               40        50        60        70        80        90

         250       260       270       280       290       300     
pF1KA0 MLRRENGQLLRERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSSEILNKLYDT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MLRRENGQLLRERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSSEILNKLYDT
              100       110       120       130       140       150

         310       320       330       340       350       360     
pF1KA0 AMDKLEVVKKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRDTAIQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AMDKLEVVKKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRDTAIQL
              160       170       180       190       200       210

         370       380       390       400       410       420     
pF1KA0 QHQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEKYREER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QHQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEKYREER
              220       230       240       250       260       270

         430       440       450       460       470       480     
pF1KA0 DAVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAANEEMEALRQIKDTVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DAVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAANEEMEALRQIKDTVT
              280       290       300       310       320       330

         490       500       510       520       530       540     
pF1KA0 MDAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERDSIRTLCD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MDAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERDSIRTLCD
              340       350       360       370       380       390

         550       560       570       580       590       600     
pF1KA0 NLRRERDRAVSELAEALRSLDDTRKQKNDVSRELKELKEQMESQLEKEARFRQLMAHSSH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLRRERDRAVSELAEALRSLDDTRKQKNDVSRELKELKEQMESQLEKEARFRQLMAHSSH
              400       410       420       430       440       450

         610       620       630       640       650       660     
pF1KA0 DSAIDTDSMEWETEVVEFERETEDIDLKALGFDMAEGVNEPCFPGDCGIFVTKVDKGSIA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DSAIDTDSMEWETEVVEFERETEDIDLKALGFDMAEGVNEPCFPGDCGIFVTKVDKGSIA
              460       470       480       490       500       510

         670       680       690       700       710       720     
pF1KA0 DGRLRVNDWLLRINDVDLINKDKKQAIKALLNGEGAINMVVRRRKSLGGKVVTPLHINLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DGRLRVNDWLLRINDVDLINKDKKQAIKALLNGEGAINMVVRRRKSLGGKVVTPLHINLS
              520       530       540       550       560       570

         730       740       750       760       770       780     
pF1KA0 GQKDSGISLENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESLLRSCQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GQKDSGISLENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESLLRSCQ
              580       590       600       610       620       630

         790       800       810       820       830       840     
pF1KA0 DSLTLSLLKVFPQSSSWSGQNIFENIKDSDKMLSFRAHGPEVQAHNKRNLIQHNNSTQTD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DSLTLSLLKVFPQSSSWSGQNIFENIKDSDKMLSFRAHGPEVQAHNKRNLIQHNNSTQTD
              640       650       660       670       680       690

         850       860       870       880       890       900     
pF1KA0 IFYTDRLEDRKEPGPPGGSSSFLHKPFPGGPLQVCPQACPSASERSLSSFRSDASGDRGF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IFYTDRLEDRKEPGPPGGSSSFLHKPFPGGPLQVCPQACPSASERSLSSFRSDASGDRGF
              700       710       720       730       740       750

         910       920       930       940       950       960     
pF1KA0 GLVDVRGRRPLLPFETEVGPCGVGEASLDKADSEGSNSGGTWPKAMLSSTAVPEKLSVYK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLVDVRGRRPLLPFETEVGPCGVGEASLDKADSEGSNSGGTWPKAMLSSTAVPEKLSVYK
              760       770       780       790       800       810

         970       980       990      1000      1010      1020     
pF1KA0 KPKQRKSIFDPNTFKRPQTPPKIDYLLPGPGPAHSPQPSKRAGPLTPPKPPRRSDSIKFQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KPKQRKSIFDPNTFKRPQTPPKIDYLLPGPGPAHSPQPSKRAGPLTPPKPPRRSDSIKFQ
              820       830       840       850       860       870

        1030      1040      1050      1060      1070      1080     
pF1KA0 HRLETSSESEATLVGSSPSTSPPSALPPDVDPGEPMHASPPRKARVRIASSYYPEGDGDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HRLETSSESEATLVGSSPSTSPPSALPPDVDPGEPMHASPPRKARVRIASSYYPEGDGDS
              880       890       900       910       920       930

        1090      1100      1110      1120      1130      1140     
pF1KA0 SHLPAKKSCDEDLTSQKVDELGQKRRRPKSAPSFRPKLAPVVIPAQFLEEQKCVPASGEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SHLPAKKSCDEDLTSQKVDELGQKRRRPKSAPSFRPKLAPVVIPAQFLEEQKCVPASGEL
              940       950       960       970       980       990

        1150      1160      1170      1180      1190      1200     
pF1KA0 SPELQEWAPYSPGHSSRHSNPPLYPSRPSVGTVPRSLTPSTTVSSILRNPIYTVRSHRVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPELQEWAPYSPGHSSRHSNPPLYPSRPSVGTVPRSLTPSTTVSSILRNPIYTVRSHRVG
             1000      1010      1020      1030      1040      1050

        1210      1220      1230      1240      1250      1260     
pF1KA0 PCSSPPAARDAGPQGLHPSVQHQGRLSLDLSHRTCSDYSEMRATHGSNSLPSSARLGSSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PCSSPPAARDAGPQGLHPSVQHQGRLSLDLSHRTCSDYSEMRATHGSNSLPSSARLGSSS
             1060      1070      1080      1090      1100      1110

        1270      1280      1290      1300      1310      1320     
pF1KA0 NLQFKAERIKIPSTPRYPRSVVGSERGSVSHSECSTPPQSPLNIDTLSSCSQSQTSASTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLQFKAERIKIPSTPRYPRSVVGSERGSVSHSECSTPPQSPLNIDTLSSCSQSQTSASTL
             1120      1130      1140      1150      1160      1170

        1330      1340      1350      1360      1370      1380     
pF1KA0 PRIAVNPASLGERRKDRPYVEEPRHVKVQKGSEPLGISIVSGEKGGIYVSKVTVGSIAHQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PRIAVNPASLGERRKDRPYVEEPRHVKVQKGSEPLGISIVSGEKGGIYVSKVTVGSIAHQ
             1180      1190      1200      1210      1220      1230

        1390      1400      1410      1420      1430      1440     
pF1KA0 AGLEYGDQLLEFNGINLRSATEQQARLIIGQQCDTITILAQYNPHVHQLSSHSRSSSHLD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGLEYGDQLLEFNGINLRSATEQQARLIIGQQCDTITILAQYNPHVHQLSSHSRSSSHLD
             1240      1250      1260      1270      1280      1290

        1450      1460      1470      1480      1490      1500     
pF1KA0 PAGTHSTLQGSGTTTPEHPSVIDPLMEQDEGPSTPPAKQSSSRIAGDANKKTLEPRVVFI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PAGTHSTLQGSGTTTPEHPSVIDPLMEQDEGPSTPPAKQSSSRIAGDANKKTLEPRVVFI
             1300      1310      1320      1330      1340      1350

        1510      1520      1530      1540      1550      1560     
pF1KA0 KKSQLELGVHLCGGNLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVRNKTVEEVYV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KKSQLELGVHLCGGNLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVRNKTVEEVYV
             1360      1370      1380      1390      1400      1410

        1570      1580      1590      1600      1610      1620     
pF1KA0 EMLKPRDGVRLKVQYRPEEFTKAKGLPGDSFYIRALYDRLADVEQELSFKKDDILYVDDT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EMLKPRDGVRLKVQYRPEEFTKAKGLPGDSFYIRALYDRLADVEQELSFKKDDILYVDDT
             1420      1430      1440      1450      1460      1470

        1630      1640      1650      1660      1670      1680     
pF1KA0 LPQGTFGSWMAWQLDENAQKIQRGQIPSKYVMDQEFSRRLSMSEVKDDNSATKTLSAAAR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LPQGTFGSWMAWQLDENAQKIQRGQIPSKYVMDQEFSRRLSMSEVKDDNSATKTLSAAAR
             1480      1490      1500      1510      1520      1530

        1690      1700      1710      1720      1730      1740     
pF1KA0 RSFFRRKHKHKRSGSKDGKDLLALDAFSSDSIPLFEDSVSLAYQRVQKVDCTALRPVLIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSFFRRKHKHKRSGSKDGKDLLALDAFSSDSIPLFEDSVSLAYQRVQKVDCTALRPVLIL
             1540      1550      1560      1570      1580      1590

        1750      1760      1770      1780      1790      1800     
pF1KA0 GPLLDVVKEMLVNEAPGKFCRCPLEVMKASQQAIERGVKDCLFVDYKRRSGHFDVTTVAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GPLLDVVKEMLVNEAPGKFCRCPLEVMKASQQAIERGVKDCLFVDYKRRSGHFDVTTVAS
             1600      1610      1620      1630      1640      1650

        1810      1820      1830      1840      1850      1860     
pF1KA0 IKEITEKNRHCLLDIAPHAIERLHHMHIYPIVIFIHYKSAKHIKEQRDPIYLRDKVTQRH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IKEITEKNRHCLLDIAPHAIERLHHMHIYPIVIFIHYKSAKHIKEQRDPIYLRDKVTQRH
             1660      1670      1680      1690      1700      1710

        1870      1880      1890      1900      1910         
pF1KA0 SKEQFEAAQKLEQEYSRYFTGVIQGGALSSICTQILAMVNQEQNKVLWIPACPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKEQFEAAQKLEQEYSRYFTGVIQGGALSSICTQILAMVNQEQNKVLWIPACPL
             1720      1730      1740      1750      1760    

>>XP_011538648 (OMIM: 604090) PREDICTED: disks large hom  (1680 aa)
 initn: 10924 init1: 10924 opt: 10924  Z-score: 4635.2  bits: 870.9 E(85289):    0
Smith-Waterman score: 10924; 99.9% identity (100.0% similar) in 1656 aa overlap (1-1656:1-1656)

               10        20        30        40        50        60
pF1KA0 MEPQRRELLAQCQQSLAQAMTEVEAVLGLLEAAGALSPGERRQLDEEAGGAKAELLLKLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEPQRRELLAQCQQSLAQAMTEVEAVLGLLEAAGALSPGERRQLDEEAGGAKAELLLKLL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 LAKERDHFQDLRAALEKTQPHLLPILYLNGVVGPPQPAEGAGSTYSVLSTMPSDSESSSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAKERDHFQDLRAALEKTQPHLLPILYLNGVVGPPQPAEGAGSTYSVLSTMPSDSESSSS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 LSSVGTTGKAPSPPPLLTDRQVNEKVENLSIQLRLMTRERNELRKRLAFATHGTAFDKRP
       :::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::
XP_011 LSSVGTTGKAPSPPPLLTDQQVNEKVENLSIQLRLMTRERNELRKRLAFATHGTAFDKRP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 YHRLNPDYERLKIQCVRAMSDLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLSDQTRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YHRLNPDYERLKIQCVRAMSDLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLSDQTRL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA0 KDDVDMLRRENGQLLRERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSSEILN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDDVDMLRRENGQLLRERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSSEILN
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA0 KLYDTAMDKLEVVKKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLYDTAMDKLEVVKKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRD
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA0 TAIQLQHQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TAIQLQHQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEK
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KA0 YREERDAVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAANEEMEALRQI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YREERDAVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAANEEMEALRQI
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KA0 KDTVTMDAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERDSI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDTVTMDAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERDSI
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KA0 RTLCDNLRRERDRAVSELAEALRSLDDTRKQKNDVSRELKELKEQMESQLEKEARFRQLM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTLCDNLRRERDRAVSELAEALRSLDDTRKQKNDVSRELKELKEQMESQLEKEARFRQLM
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KA0 AHSSHDSAIDTDSMEWETEVVEFERETEDIDLKALGFDMAEGVNEPCFPGDCGIFVTKVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AHSSHDSAIDTDSMEWETEVVEFERETEDIDLKALGFDMAEGVNEPCFPGDCGIFVTKVD
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KA0 KGSIADGRLRVNDWLLRINDVDLINKDKKQAIKALLNGEGAINMVVRRRKSLGGKVVTPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KGSIADGRLRVNDWLLRINDVDLINKDKKQAIKALLNGEGAINMVVRRRKSLGGKVVTPL
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KA0 HINLSGQKDSGISLENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HINLSGQKDSGISLENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESL
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KA0 LRSCQDSLTLSLLKVFPQSSSWSGQNIFENIKDSDKMLSFRAHGPEVQAHNKRNLIQHNN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRSCQDSLTLSLLKVFPQSSSWSGQNIFENIKDSDKMLSFRAHGPEVQAHNKRNLIQHNN
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KA0 STQTDIFYTDRLEDRKEPGPPGGSSSFLHKPFPGGPLQVCPQACPSASERSLSSFRSDAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 STQTDIFYTDRLEDRKEPGPPGGSSSFLHKPFPGGPLQVCPQACPSASERSLSSFRSDAS
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KA0 GDRGFGLVDVRGRRPLLPFETEVGPCGVGEASLDKADSEGSNSGGTWPKAMLSSTAVPEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GDRGFGLVDVRGRRPLLPFETEVGPCGVGEASLDKADSEGSNSGGTWPKAMLSSTAVPEK
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KA0 LSVYKKPKQRKSIFDPNTFKRPQTPPKIDYLLPGPGPAHSPQPSKRAGPLTPPKPPRRSD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSVYKKPKQRKSIFDPNTFKRPQTPPKIDYLLPGPGPAHSPQPSKRAGPLTPPKPPRRSD
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KA0 SIKFQHRLETSSESEATLVGSSPSTSPPSALPPDVDPGEPMHASPPRKARVRIASSYYPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SIKFQHRLETSSESEATLVGSSPSTSPPSALPPDVDPGEPMHASPPRKARVRIASSYYPE
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KA0 GDGDSSHLPAKKSCDEDLTSQKVDELGQKRRRPKSAPSFRPKLAPVVIPAQFLEEQKCVP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GDGDSSHLPAKKSCDEDLTSQKVDELGQKRRRPKSAPSFRPKLAPVVIPAQFLEEQKCVP
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KA0 ASGELSPELQEWAPYSPGHSSRHSNPPLYPSRPSVGTVPRSLTPSTTVSSILRNPIYTVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASGELSPELQEWAPYSPGHSSRHSNPPLYPSRPSVGTVPRSLTPSTTVSSILRNPIYTVR
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KA0 SHRVGPCSSPPAARDAGPQGLHPSVQHQGRLSLDLSHRTCSDYSEMRATHGSNSLPSSAR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SHRVGPCSSPPAARDAGPQGLHPSVQHQGRLSLDLSHRTCSDYSEMRATHGSNSLPSSAR
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KA0 LGSSSNLQFKAERIKIPSTPRYPRSVVGSERGSVSHSECSTPPQSPLNIDTLSSCSQSQT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LGSSSNLQFKAERIKIPSTPRYPRSVVGSERGSVSHSECSTPPQSPLNIDTLSSCSQSQT
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KA0 SASTLPRIAVNPASLGERRKDRPYVEEPRHVKVQKGSEPLGISIVSGEKGGIYVSKVTVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SASTLPRIAVNPASLGERRKDRPYVEEPRHVKVQKGSEPLGISIVSGEKGGIYVSKVTVG
             1330      1340      1350      1360      1370      1380

             1390      1400      1410      1420      1430      1440
pF1KA0 SIAHQAGLEYGDQLLEFNGINLRSATEQQARLIIGQQCDTITILAQYNPHVHQLSSHSRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SIAHQAGLEYGDQLLEFNGINLRSATEQQARLIIGQQCDTITILAQYNPHVHQLSSHSRS
             1390      1400      1410      1420      1430      1440

             1450      1460      1470      1480      1490      1500
pF1KA0 SSHLDPAGTHSTLQGSGTTTPEHPSVIDPLMEQDEGPSTPPAKQSSSRIAGDANKKTLEP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSHLDPAGTHSTLQGSGTTTPEHPSVIDPLMEQDEGPSTPPAKQSSSRIAGDANKKTLEP
             1450      1460      1470      1480      1490      1500

             1510      1520      1530      1540      1550      1560
pF1KA0 RVVFIKKSQLELGVHLCGGNLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVRNKTV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RVVFIKKSQLELGVHLCGGNLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVRNKTV
             1510      1520      1530      1540      1550      1560

             1570      1580      1590      1600      1610      1620
pF1KA0 EEVYVEMLKPRDGVRLKVQYRPEEFTKAKGLPGDSFYIRALYDRLADVEQELSFKKDDIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEVYVEMLKPRDGVRLKVQYRPEEFTKAKGLPGDSFYIRALYDRLADVEQELSFKKDDIL
             1570      1580      1590      1600      1610      1620

             1630      1640      1650      1660      1670      1680
pF1KA0 YVDDTLPQGTFGSWMAWQLDENAQKIQRGQIPSKYVMDQEFSRRLSMSEVKDDNSATKTL
       ::::::::::::::::::::::::::::::::::::                        
XP_011 YVDDTLPQGTFGSWMAWQLDENAQKIQRGQIPSKYVKRNSSCHQLKAVLAVPFDTELNML
             1630      1640      1650      1660      1670      1680

             1690      1700      1710      1720      1730      1740
pF1KA0 SAAARRSFFRRKHKHKRSGSKDGKDLLALDAFSSDSIPLFEDSVSLAYQRVQKVDCTALR

>>XP_016872404 (OMIM: 604090) PREDICTED: disks large hom  (1613 aa)
 initn: 10688 init1: 10688 opt: 10688  Z-score: 4535.7  bits: 852.4 E(85289):    0
Smith-Waterman score: 10688; 100.0% identity (100.0% similar) in 1613 aa overlap (307-1919:1-1613)

        280       290       300       310       320       330      
pF1KA0 KEIGDLRAQQQQVLKHNGSSEILNKLYDTAMDKLEVVKKDYDALRKRYSEKVAIHNADLS
                                     ::::::::::::::::::::::::::::::
XP_016                               MDKLEVVKKDYDALRKRYSEKVAIHNADLS
                                             10        20        30

        340       350       360       370       380       390      
pF1KA0 RLEQLGEENQRLLKQTEMLTQQRDTAIQLQHQCALSLRRFEAIHHELNKATAQNKDLQWE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLEQLGEENQRLLKQTEMLTQQRDTAIQLQHQCALSLRRFEAIHHELNKATAQNKDLQWE
               40        50        60        70        80        90

        400       410       420       430       440       450      
pF1KA0 MELLQSELTELRTTQVKTAKESEKYREERDAVYSEYKLIMSERDQVISELDKLQTEVELA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MELLQSELTELRTTQVKTAKESEKYREERDAVYSEYKLIMSERDQVISELDKLQTEVELA
              100       110       120       130       140       150

        460       470       480       490       500       510      
pF1KA0 ESKLKSSTSEKKAANEEMEALRQIKDTVTMDAGRANKEVEILRKQCKALCQELKEALQEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESKLKSSTSEKKAANEEMEALRQIKDTVTMDAGRANKEVEILRKQCKALCQELKEALQEA
              160       170       180       190       200       210

        520       530       540       550       560       570      
pF1KA0 DVAKCRRDWAFQERDKIVAERDSIRTLCDNLRRERDRAVSELAEALRSLDDTRKQKNDVS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DVAKCRRDWAFQERDKIVAERDSIRTLCDNLRRERDRAVSELAEALRSLDDTRKQKNDVS
              220       230       240       250       260       270

        580       590       600       610       620       630      
pF1KA0 RELKELKEQMESQLEKEARFRQLMAHSSHDSAIDTDSMEWETEVVEFERETEDIDLKALG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RELKELKEQMESQLEKEARFRQLMAHSSHDSAIDTDSMEWETEVVEFERETEDIDLKALG
              280       290       300       310       320       330

        640       650       660       670       680       690      
pF1KA0 FDMAEGVNEPCFPGDCGIFVTKVDKGSIADGRLRVNDWLLRINDVDLINKDKKQAIKALL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FDMAEGVNEPCFPGDCGIFVTKVDKGSIADGRLRVNDWLLRINDVDLINKDKKQAIKALL
              340       350       360       370       380       390

        700       710       720       730       740       750      
pF1KA0 NGEGAINMVVRRRKSLGGKVVTPLHINLSGQKDSGISLENGVYAAAVLPGSPAAKEGSLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NGEGAINMVVRRRKSLGGKVVTPLHINLSGQKDSGISLENGVYAAAVLPGSPAAKEGSLA
              400       410       420       430       440       450

        760       770       780       790       800       810      
pF1KA0 VGDRIVAINGIALDNKSLNECESLLRSCQDSLTLSLLKVFPQSSSWSGQNIFENIKDSDK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VGDRIVAINGIALDNKSLNECESLLRSCQDSLTLSLLKVFPQSSSWSGQNIFENIKDSDK
              460       470       480       490       500       510

        820       830       840       850       860       870      
pF1KA0 MLSFRAHGPEVQAHNKRNLIQHNNSTQTDIFYTDRLEDRKEPGPPGGSSSFLHKPFPGGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MLSFRAHGPEVQAHNKRNLIQHNNSTQTDIFYTDRLEDRKEPGPPGGSSSFLHKPFPGGP
              520       530       540       550       560       570

        880       890       900       910       920       930      
pF1KA0 LQVCPQACPSASERSLSSFRSDASGDRGFGLVDVRGRRPLLPFETEVGPCGVGEASLDKA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQVCPQACPSASERSLSSFRSDASGDRGFGLVDVRGRRPLLPFETEVGPCGVGEASLDKA
              580       590       600       610       620       630

        940       950       960       970       980       990      
pF1KA0 DSEGSNSGGTWPKAMLSSTAVPEKLSVYKKPKQRKSIFDPNTFKRPQTPPKIDYLLPGPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSEGSNSGGTWPKAMLSSTAVPEKLSVYKKPKQRKSIFDPNTFKRPQTPPKIDYLLPGPG
              640       650       660       670       680       690

       1000      1010      1020      1030      1040      1050      
pF1KA0 PAHSPQPSKRAGPLTPPKPPRRSDSIKFQHRLETSSESEATLVGSSPSTSPPSALPPDVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PAHSPQPSKRAGPLTPPKPPRRSDSIKFQHRLETSSESEATLVGSSPSTSPPSALPPDVD
              700       710       720       730       740       750

       1060      1070      1080      1090      1100      1110      
pF1KA0 PGEPMHASPPRKARVRIASSYYPEGDGDSSHLPAKKSCDEDLTSQKVDELGQKRRRPKSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGEPMHASPPRKARVRIASSYYPEGDGDSSHLPAKKSCDEDLTSQKVDELGQKRRRPKSA
              760       770       780       790       800       810

       1120      1130      1140      1150      1160      1170      
pF1KA0 PSFRPKLAPVVIPAQFLEEQKCVPASGELSPELQEWAPYSPGHSSRHSNPPLYPSRPSVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSFRPKLAPVVIPAQFLEEQKCVPASGELSPELQEWAPYSPGHSSRHSNPPLYPSRPSVG
              820       830       840       850       860       870

       1180      1190      1200      1210      1220      1230      
pF1KA0 TVPRSLTPSTTVSSILRNPIYTVRSHRVGPCSSPPAARDAGPQGLHPSVQHQGRLSLDLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TVPRSLTPSTTVSSILRNPIYTVRSHRVGPCSSPPAARDAGPQGLHPSVQHQGRLSLDLS
              880       890       900       910       920       930

       1240      1250      1260      1270      1280      1290      
pF1KA0 HRTCSDYSEMRATHGSNSLPSSARLGSSSNLQFKAERIKIPSTPRYPRSVVGSERGSVSH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HRTCSDYSEMRATHGSNSLPSSARLGSSSNLQFKAERIKIPSTPRYPRSVVGSERGSVSH
              940       950       960       970       980       990

       1300      1310      1320      1330      1340      1350      
pF1KA0 SECSTPPQSPLNIDTLSSCSQSQTSASTLPRIAVNPASLGERRKDRPYVEEPRHVKVQKG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SECSTPPQSPLNIDTLSSCSQSQTSASTLPRIAVNPASLGERRKDRPYVEEPRHVKVQKG
             1000      1010      1020      1030      1040      1050

       1360      1370      1380      1390      1400      1410      
pF1KA0 SEPLGISIVSGEKGGIYVSKVTVGSIAHQAGLEYGDQLLEFNGINLRSATEQQARLIIGQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SEPLGISIVSGEKGGIYVSKVTVGSIAHQAGLEYGDQLLEFNGINLRSATEQQARLIIGQ
             1060      1070      1080      1090      1100      1110

       1420      1430      1440      1450      1460      1470      
pF1KA0 QCDTITILAQYNPHVHQLSSHSRSSSHLDPAGTHSTLQGSGTTTPEHPSVIDPLMEQDEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QCDTITILAQYNPHVHQLSSHSRSSSHLDPAGTHSTLQGSGTTTPEHPSVIDPLMEQDEG
             1120      1130      1140      1150      1160      1170

       1480      1490      1500      1510      1520      1530      
pF1KA0 PSTPPAKQSSSRIAGDANKKTLEPRVVFIKKSQLELGVHLCGGNLHGVFVAEVEDDSPAK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSTPPAKQSSSRIAGDANKKTLEPRVVFIKKSQLELGVHLCGGNLHGVFVAEVEDDSPAK
             1180      1190      1200      1210      1220      1230

       1540      1550      1560      1570      1580      1590      
pF1KA0 GPDGLVPGDLILEYGSLDVRNKTVEEVYVEMLKPRDGVRLKVQYRPEEFTKAKGLPGDSF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPDGLVPGDLILEYGSLDVRNKTVEEVYVEMLKPRDGVRLKVQYRPEEFTKAKGLPGDSF
             1240      1250      1260      1270      1280      1290

       1600      1610      1620      1630      1640      1650      
pF1KA0 YIRALYDRLADVEQELSFKKDDILYVDDTLPQGTFGSWMAWQLDENAQKIQRGQIPSKYV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YIRALYDRLADVEQELSFKKDDILYVDDTLPQGTFGSWMAWQLDENAQKIQRGQIPSKYV
             1300      1310      1320      1330      1340      1350

       1660      1670      1680      1690      1700      1710      
pF1KA0 MDQEFSRRLSMSEVKDDNSATKTLSAAARRSFFRRKHKHKRSGSKDGKDLLALDAFSSDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MDQEFSRRLSMSEVKDDNSATKTLSAAARRSFFRRKHKHKRSGSKDGKDLLALDAFSSDS
             1360      1370      1380      1390      1400      1410

       1720      1730      1740      1750      1760      1770      
pF1KA0 IPLFEDSVSLAYQRVQKVDCTALRPVLILGPLLDVVKEMLVNEAPGKFCRCPLEVMKASQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IPLFEDSVSLAYQRVQKVDCTALRPVLILGPLLDVVKEMLVNEAPGKFCRCPLEVMKASQ
             1420      1430      1440      1450      1460      1470

       1780      1790      1800      1810      1820      1830      
pF1KA0 QAIERGVKDCLFVDYKRRSGHFDVTTVASIKEITEKNRHCLLDIAPHAIERLHHMHIYPI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QAIERGVKDCLFVDYKRRSGHFDVTTVASIKEITEKNRHCLLDIAPHAIERLHHMHIYPI
             1480      1490      1500      1510      1520      1530

       1840      1850      1860      1870      1880      1890      
pF1KA0 VIFIHYKSAKHIKEQRDPIYLRDKVTQRHSKEQFEAAQKLEQEYSRYFTGVIQGGALSSI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VIFIHYKSAKHIKEQRDPIYLRDKVTQRHSKEQFEAAQKLEQEYSRYFTGVIQGGALSSI
             1540      1550      1560      1570      1580      1590

       1900      1910         
pF1KA0 CTQILAMVNQEQNKVLWIPACPL
       :::::::::::::::::::::::
XP_016 CTQILAMVNQEQNKVLWIPACPL
             1600      1610   




1919 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 09:47:39 2016 done: Thu Nov  3 09:47:42 2016
 Total Scan time: 22.120 Total Display time:  1.370

Function used was FASTA [36.3.4 Apr, 2011]
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