Result of FASTA (omim) for pF1KSDB0017
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KSDB0017, 1740 aa
  1>>>pF1KSDB0017 1740 - 1740 aa - 1740 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 7.8578+/-0.000371; mu= 13.6749+/- 0.024
 mean_var=150.5098+/-30.677, 0's: 0 Z-trim(117.5): 106  B-trim: 16 in 3/57
 Lambda= 0.104542
 statistics sampled from 29419 (29525) to 29419 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.663), E-opt: 0.2 (0.346), width:  16
 Scan time: 22.530

The best scores are:                                      opt bits E(85289)
NP_001070651 (OMIM: 191092,606690,613254) tuberin  (1740) 11464 1742.0       0
NP_001305761 (OMIM: 191092,606690,613254) tuberin  (1751) 11464 1742.0       0
XP_005255588 (OMIM: 191092,606690,613254) PREDICTE (1741) 11452 1740.2       0
NP_001305758 (OMIM: 191092,606690,613254) tuberin  (1692) 11143 1693.6       0
NP_001305756 (OMIM: 191092,606690,613254) tuberin  (1704) 10733 1631.8       0
XP_016879106 (OMIM: 191092,606690,613254) PREDICTE (1795) 10733 1631.8       0
XP_011520942 (OMIM: 191092,606690,613254) PREDICTE (1781) 8042 1225.9       0
XP_016879105 (OMIM: 191092,606690,613254) PREDICTE (1763) 8033 1224.5       0
XP_011520941 (OMIM: 191092,606690,613254) PREDICTE (1782) 8025 1223.3       0
XP_005255586 (OMIM: 191092,606690,613254) PREDICTE (1764) 8021 1222.7       0
NP_001305760 (OMIM: 191092,606690,613254) tuberin  (1563) 6740 1029.5       0
NP_001107854 (OMIM: 191092,606690,613254) tuberin  (1784) 6223 951.6       0
XP_016879104 (OMIM: 191092,606690,613254) PREDICTE (1806) 6223 951.6       0
NP_000539 (OMIM: 191092,606690,613254) tuberin iso (1807) 6223 951.6       0
XP_011520939 (OMIM: 191092,606690,613254) PREDICTE (1824) 6223 951.6       0
XP_011520938 (OMIM: 191092,606690,613254) PREDICTE (1825) 6223 951.6       0
XP_011520940 (OMIM: 191092,606690,613254) PREDICTE (1879) 5504 843.1       0
XP_016879107 (OMIM: 191092,606690,613254) PREDICTE (1377) 3436 531.2 2.6e-149
NP_919277 (OMIM: 608884) ral GTPase-activating pro (2083)  350 65.8 4.7e-09
XP_005267549 (OMIM: 608884) PREDICTED: ral GTPase- (2130)  350 65.8 4.8e-09
XP_006720162 (OMIM: 608884) PREDICTED: ral GTPase- (2589)  350 65.9 5.7e-09
XP_005267555 (OMIM: 608884) PREDICTED: ral GTPase- (1325)  343 64.6 6.8e-09
XP_016876636 (OMIM: 608884) PREDICTED: ral GTPase- (1327)  343 64.6 6.8e-09
XP_016876635 (OMIM: 608884) PREDICTED: ral GTPase- (1834)  343 64.7 8.9e-09
NP_055805 (OMIM: 608884) ral GTPase-activating pro (2036)  343 64.8 9.7e-09
NP_001333172 (OMIM: 608884) ral GTPase-activating  (2036)  343 64.8 9.7e-09
NP_001269972 (OMIM: 608884) ral GTPase-activating  (2049)  343 64.8 9.7e-09
NP_001269973 (OMIM: 608884) ral GTPase-activating  (2083)  343 64.8 9.9e-09
NP_001333174 (OMIM: 608884) ral GTPase-activating  (2083)  343 64.8 9.9e-09
NP_001333175 (OMIM: 608884) ral GTPase-activating  (2084)  343 64.8 9.9e-09
NP_001333176 (OMIM: 608884) ral GTPase-activating  (2131)  343 64.8   1e-08
NP_001317004 (OMIM: 608884) ral GTPase-activating  (2495)  343 64.8 1.1e-08
NP_001333177 (OMIM: 608884) ral GTPase-activating  (2495)  343 64.8 1.1e-08
XP_006720164 (OMIM: 608884) PREDICTED: ral GTPase- (2542)  343 64.8 1.2e-08
NP_001333178 (OMIM: 608884) ral GTPase-activating  (2542)  343 64.8 1.2e-08
XP_011534917 (OMIM: 608884) PREDICTED: ral GTPase- (2542)  343 64.8 1.2e-08
XP_006720163 (OMIM: 608884) PREDICTED: ral GTPase- (2543)  343 64.8 1.2e-08
XP_006720161 (OMIM: 608884) PREDICTED: ral GTPase- (2590)  343 64.8 1.2e-08
XP_016857466 (OMIM: 600278) PREDICTED: rap1 GTPase ( 617)  249 50.3 6.7e-05
XP_016857480 (OMIM: 600278) PREDICTED: rap1 GTPase ( 625)  249 50.3 6.8e-05
XP_016857465 (OMIM: 600278) PREDICTED: rap1 GTPase ( 625)  249 50.3 6.8e-05
XP_016857463 (OMIM: 600278) PREDICTED: rap1 GTPase ( 651)  249 50.3   7e-05
XP_016857479 (OMIM: 600278) PREDICTED: rap1 GTPase ( 655)  249 50.3 7.1e-05
XP_016857461 (OMIM: 600278) PREDICTED: rap1 GTPase ( 655)  249 50.3 7.1e-05
XP_016857464 (OMIM: 600278) PREDICTED: rap1 GTPase ( 655)  249 50.3 7.1e-05
XP_016857478 (OMIM: 600278) PREDICTED: rap1 GTPase ( 655)  249 50.3 7.1e-05
XP_016857476 (OMIM: 600278) PREDICTED: rap1 GTPase ( 663)  249 50.3 7.1e-05
XP_016857462 (OMIM: 600278) PREDICTED: rap1 GTPase ( 663)  249 50.3 7.1e-05
XP_016857475 (OMIM: 600278) PREDICTED: rap1 GTPase ( 663)  249 50.3 7.1e-05
NP_002876 (OMIM: 600278) rap1 GTPase-activating pr ( 663)  249 50.3 7.1e-05


>>NP_001070651 (OMIM: 191092,606690,613254) tuberin isof  (1740 aa)
 initn: 11464 init1: 11464 opt: 11464  Z-score: 9343.8  bits: 1742.0 E(85289):    0
Smith-Waterman score: 11464; 100.0% identity (100.0% similar) in 1740 aa overlap (1-1740:1-1740)

               10        20        30        40        50        60
pF1KSD MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KSD EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KSD PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KSD SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KSD GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KSD VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KSD DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KSD VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KSD RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKRIQTSLTSASLGSAD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKRIQTSLTSASLGSAD
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KSD ENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGN
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KSD KLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGA
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KSD RDRVRSMSGGHGLRVGALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RDRVRSMSGGHGLRVGALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLA
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KSD AYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEH
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KSD RDTALYKSLSVPAASTAKPPPLPRSNTDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RDTALYKSLSVPAASTAKPPPLPRSNTDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMD
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KSD RRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSS
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KSD SPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLPS
             1330      1340      1350      1360      1370      1380

             1390      1400      1410      1420      1430      1440
pF1KSD SSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFVFLQLYHS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFVFLQLYHS
             1390      1400      1410      1420      1430      1440

             1450      1460      1470      1480      1490      1500
pF1KSD PFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHG
             1450      1460      1470      1480      1490      1500

             1510      1520      1530      1540      1550      1560
pF1KSD SYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPT
             1510      1520      1530      1540      1550      1560

             1570      1580      1590      1600      1610      1620
pF1KSD KDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQC
             1570      1580      1590      1600      1610      1620

             1630      1640      1650      1660      1670      1680
pF1KSD RKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHI
             1630      1640      1650      1660      1670      1680

             1690      1700      1710      1720      1730      1740
pF1KSD KRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSVEDFTEFV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSVEDFTEFV
             1690      1700      1710      1720      1730      1740

>>NP_001305761 (OMIM: 191092,606690,613254) tuberin isof  (1751 aa)
 initn: 11464 init1: 11464 opt: 11464  Z-score: 9343.7  bits: 1742.0 E(85289):    0
Smith-Waterman score: 11464; 100.0% identity (100.0% similar) in 1740 aa overlap (1-1740:12-1751)

                          10        20        30        40         
pF1KSD            MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELS
                  :::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEGFSGASWSTMAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELS
               10        20        30        40        50        60

      50        60        70        80        90       100         
pF1KSD MECGLNNRIRMIGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MECGLNNRIRMIGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIV
               70        80        90       100       110       120

     110       120       130       140       150       160         
pF1KSD QGQGERLGVLRALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QGQGERLGVLRALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMD
              130       140       150       160       170       180

     170       180       190       200       210       220         
pF1KSD VGLSSEFLLVLVNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VGLSSEFLLVLVNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYN
              190       200       210       220       230       240

     230       240       250       260       270       280         
pF1KSD CLPAESLPLFIVTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CLPAESLPLFIVTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDA
              250       260       270       280       290       300

     290       300       310       320       330       340         
pF1KSD PLLRGAVFFVGMALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLLRGAVFFVGMALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKY
              310       320       330       340       350       360

     350       360       370       380       390       400         
pF1KSD RKELQVVAWDILLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKELQVVAWDILLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFE
              370       380       390       400       410       420

     410       420       430       440       450       460         
pF1KSD LVERCADQRPESSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVERCADQRPESSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVL
              430       440       450       460       470       480

     470       480       490       500       510       520         
pF1KSD SFVLLINRQFYEEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SFVLLINRQFYEEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLD
              490       500       510       520       530       540

     530       540       550       560       570       580         
pF1KSD IIEKVMARSLSPPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IIEKVMARSLSPPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEM
              550       560       570       580       590       600

     590       600       610       620       630       640         
pF1KSD LVSHIQLHYKHSYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVSHIQLHYKHSYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYM
              610       620       630       640       650       660

     650       660       670       680       690       700         
pF1KSD EPERGSEKKTSGPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EPERGSEKKTSGPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLV
              670       680       690       700       710       720

     710       720       730       740       750       760         
pF1KSD LGRLPESLRYKVLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGRLPESLRYKVLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPV
              730       740       750       760       770       780

     770       780       790       800       810       820         
pF1KSD LTALISYHNYLDKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTALISYHNYLDKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVK
              790       800       810       820       830       840

     830       840       850       860       870       880         
pF1KSD LTHISATASMAVPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTHISATASMAVPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLA
              850       860       870       880       890       900

     890       900       910       920       930       940         
pF1KSD HHVIAMWFIRCRLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKRIQT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HHVIAMWFIRCRLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKRIQT
              910       920       930       940       950       960

     950       960       970       980       990      1000         
pF1KSD SLTSASLGSADENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLTSASLGSADENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLA
              970       980       990      1000      1010      1020

    1010      1020      1030      1040      1050      1060         
pF1KSD GGRTKTWLVGNKLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSPGVHVRQTKEAPAKLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGRTKTWLVGNKLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSPGVHVRQTKEAPAKLE
             1030      1040      1050      1060      1070      1080

    1070      1080      1090      1100      1110      1120         
pF1KSD SQAGQQVSRGARDRVRSMSGGHGLRVGALDVPASQFLGSATSPGPRTAPAAKPEKASAGT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SQAGQQVSRGARDRVRSMSGGHGLRVGALDVPASQFLGSATSPGPRTAPAAKPEKASAGT
             1090      1100      1110      1120      1130      1140

    1130      1140      1150      1160      1170      1180         
pF1KSD RVPVQEKTNLAAYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RVPVQEKTNLAAYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSN
             1150      1160      1170      1180      1190      1200

    1190      1200      1210      1220      1230      1240         
pF1KSD ALMAAERFKEHRDTALYKSLSVPAASTAKPPPLPRSNTDSAVVMEEGSPGEVPVLVEPPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALMAAERFKEHRDTALYKSLSVPAASTAKPPPLPRSNTDSAVVMEEGSPGEVPVLVEPPG
             1210      1220      1230      1240      1250      1260

    1250      1260      1270      1280      1290      1300         
pF1KSD LEDVEAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEDVEAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSF
             1270      1280      1290      1300      1310      1320

    1310      1320      1330      1340      1350      1360         
pF1KSD QPSQPLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QPSQPLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGED
             1330      1340      1350      1360      1370      1380

    1370      1380      1390      1400      1410      1420         
pF1KSD SRGQPEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGIN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRGQPEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGIN
             1390      1400      1410      1420      1430      1440

    1430      1440      1450      1460      1470      1480         
pF1KSD PSFVFLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSFVFLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSN
             1450      1460      1470      1480      1490      1500

    1490      1500      1510      1520      1530      1540         
pF1KSD SELAILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SELAILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQ
             1510      1520      1530      1540      1550      1560

    1550      1560      1570      1580      1590      1600         
pF1KSD AVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPL
             1570      1580      1590      1600      1610      1620

    1610      1620      1630      1640      1650      1660         
pF1KSD DYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIY
             1630      1640      1650      1660      1670      1680

    1670      1680      1690      1700      1710      1720         
pF1KSD PSKWIARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSKWIARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRL
             1690      1700      1710      1720      1730      1740

    1730      1740
pF1KSD ISSVEDFTEFV
       :::::::::::
NP_001 ISSVEDFTEFV
             1750 

>>XP_005255588 (OMIM: 191092,606690,613254) PREDICTED: t  (1741 aa)
 initn: 11450 init1: 6221 opt: 11452  Z-score: 9334.0  bits: 1740.2 E(85289):    0
Smith-Waterman score: 11452; 99.9% identity (99.9% similar) in 1741 aa overlap (1-1740:1-1741)

               10        20        30        40        50        60
pF1KSD MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KSD EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KSD PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KSD SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KSD GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KSD VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KSD DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KSD VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC
              850       860       870       880       890       900

              910       920       930       940        950         
pF1KSD RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPK-RIQTSLTSASLGSA
       ::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::::
XP_005 RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSRIQTSLTSASLGSA
              910       920       930       940       950       960

     960       970       980       990      1000      1010         
pF1KSD DENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVG
              970       980       990      1000      1010      1020

    1020      1030      1040      1050      1060      1070         
pF1KSD NKLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NKLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRG
             1030      1040      1050      1060      1070      1080

    1080      1090      1100      1110      1120      1130         
pF1KSD ARDRVRSMSGGHGLRVGALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ARDRVRSMSGGHGLRVGALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNL
             1090      1100      1110      1120      1130      1140

    1140      1150      1160      1170      1180      1190         
pF1KSD AAYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKE
             1150      1160      1170      1180      1190      1200

    1200      1210      1220      1230      1240      1250         
pF1KSD HRDTALYKSLSVPAASTAKPPPLPRSNTDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HRDTALYKSLSVPAASTAKPPPLPRSNTDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGM
             1210      1220      1230      1240      1250      1260

    1260      1270      1280      1290      1300      1310         
pF1KSD DRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSS
             1270      1280      1290      1300      1310      1320

    1320      1330      1340      1350      1360      1370         
pF1KSD SSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLP
             1330      1340      1350      1360      1370      1380

    1380      1390      1400      1410      1420      1430         
pF1KSD SSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFVFLQLYH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFVFLQLYH
             1390      1400      1410      1420      1430      1440

    1440      1450      1460      1470      1480      1490         
pF1KSD SPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEH
             1450      1460      1470      1480      1490      1500

    1500      1510      1520      1530      1540      1550         
pF1KSD GSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMP
             1510      1520      1530      1540      1550      1560

    1560      1570      1580      1590      1600      1610         
pF1KSD TKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQ
             1570      1580      1590      1600      1610      1620

    1620      1630      1640      1650      1660      1670         
pF1KSD CRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRH
             1630      1640      1650      1660      1670      1680

    1680      1690      1700      1710      1720      1730         
pF1KSD IKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSVEDFTEF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSVEDFTEF
             1690      1700      1710      1720      1730      1740

    1740
pF1KSD V
       :
XP_005 V
        

>>NP_001305758 (OMIM: 191092,606690,613254) tuberin isof  (1692 aa)
 initn: 11141 init1: 5912 opt: 11143  Z-score: 9082.3  bits: 1693.6 E(85289):    0
Smith-Waterman score: 11143; 99.9% identity (99.9% similar) in 1692 aa overlap (50-1740:1-1692)

      20        30        40        50        60        70         
pF1KSD GLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRMIGQICEVAKTKKFEEHAVE
                                     ::::::::::::::::::::::::::::::
NP_001                               MECGLNNRIRMIGQICEVAKTKKFEEHAVE
                                             10        20        30

      80        90       100       110       120       130         
pF1KSD ALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLRALFFKVIKDYPSNEDLHER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLRALFFKVIKDYPSNEDLHER
               40        50        60        70        80        90

     140       150       160       170       180       190         
pF1KSD LEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVLVNLVKFNSCYLDEYIARMV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVLVNLVKFNSCYLDEYIARMV
              100       110       120       130       140       150

     200       210       220       230       240       250         
pF1KSD QMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFIVTLCRTINVKELCEPCWKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFIVTLCRTINVKELCEPCWKL
              160       170       180       190       200       210

     260       270       280       290       300       310         
pF1KSD MRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVGMALWGAHRLYSLRNSPTSV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVGMALWGAHRLYSLRNSPTSV
              220       230       240       250       260       270

     320       330       340       350       360       370         
pF1KSD LPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDILLNIIERLLQQLQTLDSPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDILLNIIERLLQQLQTLDSPE
              280       290       300       310       320       330

     380       390       400       410       420       430         
pF1KSD LRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPESSLLNLISYRAQSIHPAKD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPESSLLNLISYRAQSIHPAKD
              340       350       360       370       380       390

     440       450       460       470       480       490         
pF1KSD GWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFYEEELINSVVISQLSHIPED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFYEEELINSVVISQLSHIPED
              400       410       420       430       440       450

     500       510       520       530       540       550         
pF1KSD KDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLSPPPELEERDVAAYSASLED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLSPPPELEERDVAAYSASLED
              460       470       480       490       500       510

     560       570       580       590       600       610         
pF1KSD VKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKHSYTLPIASSIRLQAFDFLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKHSYTLPIASSIRLQAFDFLL
              520       530       540       550       560       570

     620       630       640       650       660       670         
pF1KSD LLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTSGPLSPPTGPPGPAPAGPAV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTSGPLSPPTGPPGPAPAGPAV
              580       590       600       610       620       630

     680       690       700       710       720       730         
pF1KSD RLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYKVLIFTSPCSVDQLCSALCS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYKVLIFTSPCSVDQLCSALCS
              640       650       660       670       680       690

     740       750       760       770       780       790         
pF1KSD MLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYLDKTKQREMVYCLEQGLIHR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYLDKTKQREMVYCLEQGLIHR
              700       710       720       730       740       750

     800       810       820       830       840       850         
pF1KSD CASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMAVPLLEFLSTLARLPHLYRN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMAVPLLEFLSTLARLPHLYRN
              760       770       780       790       800       810

     860       870       880       890       900       910         
pF1KSD FAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRCRLPFRKDFVPFITKGLRSN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRCRLPFRKDFVPFITKGLRSN
              820       830       840       850       860       870

     920       930       940        950       960       970        
pF1KSD VLLSFDDTPEKDSFRARSTSLNERPK-RIQTSLTSASLGSADENSVAQADDSLKNLHLEL
       :::::::::::::::::::::::::: :::::::::::::::::::::::::::::::::
NP_001 VLLSFDDTPEKDSFRARSTSLNERPKSRIQTSLTSASLGSADENSVAQADDSLKNLHLEL
              880       890       900       910       920       930

      980       990      1000      1010      1020      1030        
pF1KSD TETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSLLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSLLG
              940       950       960       970       980       990

     1040      1050      1060      1070      1080      1090        
pF1KSD LDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVGAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVGAL
             1000      1010      1020      1030      1040      1050

     1100      1110      1120      1130      1140      1150        
pF1KSD DVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVRRP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVRRP
             1060      1070      1080      1090      1100      1110

     1160      1170      1180      1190      1200      1210        
pF1KSD TGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAASTAK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAASTAK
             1120      1130      1140      1150      1160      1170

     1220      1230      1240      1250      1260      1270        
pF1KSD PPPLPRSNTDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPPLPRSNTDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEK
             1180      1190      1200      1210      1220      1230

     1280      1290      1300      1310      1320      1330        
pF1KSD SLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGDKA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGDKA
             1240      1250      1260      1270      1280      1290

     1340      1350      1360      1370      1380      1390        
pF1KSD DVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTISD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTISD
             1300      1310      1320      1330      1340      1350

     1400      1410      1420      1430      1440      1450        
pF1KSD SAPSRRGKRVERDALKSRATASNAEKVPGINPSFVFLQLYHSPFFGDESNKPILLPNESQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SAPSRRGKRVERDALKSRATASNAEKVPGINPSFVFLQLYHSPFFGDESNKPILLPNESQ
             1360      1370      1380      1390      1400      1410

     1460      1470      1480      1490      1500      1510        
pF1KSD SFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELK
             1420      1430      1440      1450      1460      1470

     1520      1530      1540      1550      1560      1570        
pF1KSD DCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDF
             1480      1490      1500      1510      1520      1530

     1580      1590      1600      1610      1620      1630        
pF1KSD VSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTSVAKIVSD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTSVAKIVSD
             1540      1550      1560      1570      1580      1590

     1640      1650      1660      1670      1680      1690        
pF1KSD RNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNPSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNPSL
             1600      1610      1620      1630      1640      1650

     1700      1710      1720      1730      1740
pF1KSD PLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSVEDFTEFV
       ::::::::::::::::::::::::::::::::::::::::::
NP_001 PLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSVEDFTEFV
             1660      1670      1680      1690  

>>NP_001305756 (OMIM: 191092,606690,613254) tuberin isof  (1704 aa)
 initn: 10731 init1: 5502 opt: 10733  Z-score: 8748.1  bits: 1631.8 E(85289):    0
Smith-Waterman score: 11132; 97.8% identity (97.8% similar) in 1741 aa overlap (1-1740:1-1704)

               10        20        30        40        50        60
pF1KSD MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR
       :::::::::::::::                                     ::::::::
NP_001 IGQICEVAKTKKFEE-------------------------------------GERLGVLR
               70                                             80   

              130       140       150       160       170       180
pF1KSD ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
            90       100       110       120       130       140   

              190       200       210       220       230       240
pF1KSD VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI
           150       160       170       180       190       200   

              250       260       270       280       290       300
pF1KSD VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG
           210       220       230       240       250       260   

              310       320       330       340       350       360
pF1KSD MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI
           270       280       290       300       310       320   

              370       380       390       400       410       420
pF1KSD LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE
           330       340       350       360       370       380   

              430       440       450       460       470       480
pF1KSD SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY
           390       400       410       420       430       440   

              490       500       510       520       530       540
pF1KSD EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS
           450       460       470       480       490       500   

              550       560       570       580       590       600
pF1KSD PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH
           510       520       530       540       550       560   

              610       620       630       640       650       660
pF1KSD SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS
           570       580       590       600       610       620   

              670       680       690       700       710       720
pF1KSD GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK
           630       640       650       660       670       680   

              730       740       750       760       770       780
pF1KSD VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL
           690       700       710       720       730       740   

              790       800       810       820       830       840
pF1KSD DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA
           750       760       770       780       790       800   

              850       860       870       880       890       900
pF1KSD VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC
           810       820       830       840       850       860   

              910       920       930       940        950         
pF1KSD RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPK-RIQTSLTSASLGSA
       ::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::::
NP_001 RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSRIQTSLTSASLGSA
           870       880       890       900       910       920   

     960       970       980       990      1000      1010         
pF1KSD DENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVG
           930       940       950       960       970       980   

    1020      1030      1040      1050      1060      1070         
pF1KSD NKLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NKLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRG
           990      1000      1010      1020      1030      1040   

    1080      1090      1100      1110      1120      1130         
pF1KSD ARDRVRSMSGGHGLRVGALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ARDRVRSMSGGHGLRVGALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNL
          1050      1060      1070      1080      1090      1100   

    1140      1150      1160      1170      1180      1190         
pF1KSD AAYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AAYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKE
          1110      1120      1130      1140      1150      1160   

    1200      1210      1220      1230      1240      1250         
pF1KSD HRDTALYKSLSVPAASTAKPPPLPRSNTDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HRDTALYKSLSVPAASTAKPPPLPRSNTDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGM
          1170      1180      1190      1200      1210      1220   

    1260      1270      1280      1290      1300      1310         
pF1KSD DRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSS
          1230      1240      1250      1260      1270      1280   

    1320      1330      1340      1350      1360      1370         
pF1KSD SSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLP
          1290      1300      1310      1320      1330      1340   

    1380      1390      1400      1410      1420      1430         
pF1KSD SSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFVFLQLYH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFVFLQLYH
          1350      1360      1370      1380      1390      1400   

    1440      1450      1460      1470      1480      1490         
pF1KSD SPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEH
          1410      1420      1430      1440      1450      1460   

    1500      1510      1520      1530      1540      1550         
pF1KSD GSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMP
          1470      1480      1490      1500      1510      1520   

    1560      1570      1580      1590      1600      1610         
pF1KSD TKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQ
          1530      1540      1550      1560      1570      1580   

    1620      1630      1640      1650      1660      1670         
pF1KSD CRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRH
          1590      1600      1610      1620      1630      1640   

    1680      1690      1700      1710      1720      1730         
pF1KSD IKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSVEDFTEF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSVEDFTEF
          1650      1660      1670      1680      1690      1700   

    1740
pF1KSD V
       :
NP_001 V
        

>>XP_016879106 (OMIM: 191092,606690,613254) PREDICTED: t  (1795 aa)
 initn: 10731 init1: 5502 opt: 10733  Z-score: 8747.7  bits: 1631.8 E(85289):    0
Smith-Waterman score: 11132; 97.8% identity (97.8% similar) in 1741 aa overlap (1-1740:92-1795)

                                             10        20        30
pF1KSD                               MAKPTSKDSGLKEKFKILLGLGTPRPNPRS
                                     ::::::::::::::::::::::::::::::
XP_016 ARGVRLSPRRGGPERGGAAREGFSGASWSTMAKPTSKDSGLKEKFKILLGLGTPRPNPRS
              70        80        90       100       110       120 

               40        50        60        70        80        90
pF1KSD AEGKQTEFIITAEILRELSMECGLNNRIRMIGQICEVAKTKKFEEHAVEALWKAVADLLQ
       :::::::::::::::::::::::::::::::::::::::::::::               
XP_016 AEGKQTEFIITAEILRELSMECGLNNRIRMIGQICEVAKTKKFEE---------------
             130       140       150       160                     

              100       110       120       130       140       150
pF1KSD PERPLEARHAVLALLKAIVQGQGERLGVLRALFFKVIKDYPSNEDLHERLEVFKALTDNG
                             ::::::::::::::::::::::::::::::::::::::
XP_016 ----------------------GERLGVLRALFFKVIKDYPSNEDLHERLEVFKALTDNG
                              170       180       190       200    

              160       170       180       190       200       210
pF1KSD RHITYLEEELADFVLQWMDVGLSSEFLLVLVNLVKFNSCYLDEYIARMVQMICLLCVRTA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RHITYLEEELADFVLQWMDVGLSSEFLLVLVNLVKFNSCYLDEYIARMVQMICLLCVRTA
          210       220       230       240       250       260    

              220       230       240       250       260       270
pF1KSD SSVDIEVSLQVLDAVVCYNCLPAESLPLFIVTLCRTINVKELCEPCWKLMRNLLGTHLGH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSVDIEVSLQVLDAVVCYNCLPAESLPLFIVTLCRTINVKELCEPCWKLMRNLLGTHLGH
          270       280       290       300       310       320    

              280       290       300       310       320       330
pF1KSD SAIYNMCHLMEDRAYMEDAPLLRGAVFFVGMALWGAHRLYSLRNSPTSVLPSFYQAMACP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SAIYNMCHLMEDRAYMEDAPLLRGAVFFVGMALWGAHRLYSLRNSPTSVLPSFYQAMACP
          330       340       350       360       370       380    

              340       350       360       370       380       390
pF1KSD NEVVSYEIVLSITRLIKKYRKELQVVAWDILLNIIERLLQQLQTLDSPELRTIVHDLLTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NEVVSYEIVLSITRLIKKYRKELQVVAWDILLNIIERLLQQLQTLDSPELRTIVHDLLTT
          390       400       410       420       430       440    

              400       410       420       430       440       450
pF1KSD VEELCDQNEFHGSQERYFELVERCADQRPESSLLNLISYRAQSIHPAKDGWIQNLQALME
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VEELCDQNEFHGSQERYFELVERCADQRPESSLLNLISYRAQSIHPAKDGWIQNLQALME
          450       460       470       480       490       500    

              460       470       480       490       500       510
pF1KSD RFFRSESRGAVRIKVLDVLSFVLLINRQFYEEELINSVVISQLSHIPEDKDHQVRKLATQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RFFRSESRGAVRIKVLDVLSFVLLINRQFYEEELINSVVISQLSHIPEDKDHQVRKLATQ
          510       520       530       540       550       560    

              520       530       540       550       560       570
pF1KSD LLVDLAEGCHTHHFNSLLDIIEKVMARSLSPPPELEERDVAAYSASLEDVKTAVLGLLVI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLVDLAEGCHTHHFNSLLDIIEKVMARSLSPPPELEERDVAAYSASLEDVKTAVLGLLVI
          570       580       590       600       610       620    

              580       590       600       610       620       630
pF1KSD LQTKLYTLPASHATRVYEMLVSHIQLHYKHSYTLPIASSIRLQAFDFLLLLRADSLHRLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQTKLYTLPASHATRVYEMLVSHIQLHYKHSYTLPIASSIRLQAFDFLLLLRADSLHRLG
          630       640       650       660       670       680    

              640       650       660       670       680       690
pF1KSD LPNKDGVVRFSPYCVCDYMEPERGSEKKTSGPLSPPTGPPGPAPAGPAVRLGSVPYSLLF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPNKDGVVRFSPYCVCDYMEPERGSEKKTSGPLSPPTGPPGPAPAGPAVRLGSVPYSLLF
          690       700       710       720       730       740    

              700       710       720       730       740       750
pF1KSD RVLLQCLKQESDWKVLKLVLGRLPESLRYKVLIFTSPCSVDQLCSALCSMLSGPKTLERL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RVLLQCLKQESDWKVLKLVLGRLPESLRYKVLIFTSPCSVDQLCSALCSMLSGPKTLERL
          750       760       770       780       790       800    

              760       770       780       790       800       810
pF1KSD RGAPEGFSRTDLHLAVVPVLTALISYHNYLDKTKQREMVYCLEQGLIHRCASQCVVALSI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RGAPEGFSRTDLHLAVVPVLTALISYHNYLDKTKQREMVYCLEQGLIHRCASQCVVALSI
          810       820       830       840       850       860    

              820       830       840       850       860       870
pF1KSD CSVEMPDIIIKALPVLVVKLTHISATASMAVPLLEFLSTLARLPHLYRNFAAEQYASVFA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CSVEMPDIIIKALPVLVVKLTHISATASMAVPLLEFLSTLARLPHLYRNFAAEQYASVFA
          870       880       890       900       910       920    

              880       890       900       910       920       930
pF1KSD ISLPYTNPSKFNQYIVCLAHHVIAMWFIRCRLPFRKDFVPFITKGLRSNVLLSFDDTPEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ISLPYTNPSKFNQYIVCLAHHVIAMWFIRCRLPFRKDFVPFITKGLRSNVLLSFDDTPEK
          930       940       950       960       970       980    

              940        950       960       970       980         
pF1KSD DSFRARSTSLNERPK-RIQTSLTSASLGSADENSVAQADDSLKNLHLELTETCLDMMARY
       ::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSFRARSTSLNERPKSRIQTSLTSASLGSADENSVAQADDSLKNLHLELTETCLDMMARY
          990      1000      1010      1020      1030      1040    

     990      1000      1010      1020      1030      1040         
pF1KSD VFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSLLGLDSGELQSGPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSLLGLDSGELQSGPE
         1050      1060      1070      1080      1090      1100    

    1050      1060      1070      1080      1090      1100         
pF1KSD SSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVGALDVPASQFLGSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVGALDVPASQFLGSA
         1110      1120      1130      1140      1150      1160    

    1110      1120      1130      1140      1150      1160         
pF1KSD TSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVRRPTGNTSWLMSLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVRRPTGNTSWLMSLE
         1170      1180      1190      1200      1210      1220    

    1170      1180      1190      1200      1210      1220         
pF1KSD NPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAASTAKPPPLPRSNTDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAASTAKPPPLPRSNTDS
         1230      1240      1250      1260      1270      1280    

    1230      1240      1250      1260      1270      1280         
pF1KSD AVVMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVVMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRG
         1290      1300      1310      1320      1330      1340    

    1290      1300      1310      1320      1330      1340         
pF1KSD IPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKA
         1350      1360      1370      1380      1390      1400    

    1350      1360      1370      1380      1390      1400         
pF1KSD RSQSGTLDGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSQSGTLDGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVE
         1410      1420      1430      1440      1450      1460    

    1410      1420      1430      1440      1450      1460         
pF1KSD RDALKSRATASNAEKVPGINPSFVFLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RDALKSRATASNAEKVPGINPSFVFLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQ
         1470      1480      1490      1500      1510      1520    

    1470      1480      1490      1500      1510      1520         
pF1KSD IPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGG
         1530      1540      1550      1560      1570      1580    

    1530      1540      1550      1560      1570      1580         
pF1KSD LDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGED
         1590      1600      1610      1620      1630      1640    

    1590      1600      1610      1620      1630      1640         
pF1KSD FKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMA
         1650      1660      1670      1680      1690      1700    

    1650      1660      1670      1680      1690      1700         
pF1KSD LHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKA
         1710      1720      1730      1740      1750      1760    

    1710      1720      1730      1740
pF1KSD PAQTPAEPTPGYEVGQRKRLISSVEDFTEFV
       :::::::::::::::::::::::::::::::
XP_016 PAQTPAEPTPGYEVGQRKRLISSVEDFTEFV
         1770      1780      1790     

>>XP_011520942 (OMIM: 191092,606690,613254) PREDICTED: t  (1781 aa)
 initn: 11450 init1: 8033 opt: 8042  Z-score: 6554.3  bits: 1225.9 E(85289):    0
Smith-Waterman score: 11316; 97.7% identity (97.7% similar) in 1772 aa overlap (1-1731:1-1772)

               10        20        30        40        50        60
pF1KSD MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KSD EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KSD PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KSD SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KSD GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KSD VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KSD DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KSD VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KSD RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKRIQTSLTSASLGSAD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKRIQTSLTSASLGSAD
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KSD ENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGN
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KSD KLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGA
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KSD RDRVRSMSGGHGLRVGALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RDRVRSMSGGHGLRVGALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLA
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KSD AYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEH
             1150      1160      1170      1180      1190      1200

             1210      1220                                        
pF1KSD RDTALYKSLSVPAASTAKPPPLPRSNT---------------------------------
       :::::::::::::::::::::::::::                                 
XP_011 RDTALYKSLSVPAASTAKPPPLPRSNTVASFSSLYQSSCQGQLHRSVSWAGIASQREAVG
             1210      1220      1230      1240      1250      1260

              1230      1240      1250      1260      1270         
pF1KSD --------DSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEKS
               ::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CRAPLCLIDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEKS
             1270      1280      1290      1300      1310      1320

    1280      1290      1300      1310      1320      1330         
pF1KSD LHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGDKAD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGDKAD
             1330      1340      1350      1360      1370      1380

    1340      1350      1360      1370      1380      1390         
pF1KSD VGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTISDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTISDS
             1390      1400      1410      1420      1430      1440

    1400      1410      1420      1430      1440      1450         
pF1KSD APSRRGKRVERDALKSRATASNAEKVPGINPSFVFLQLYHSPFFGDESNKPILLPNESQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APSRRGKRVERDALKSRATASNAEKVPGINPSFVFLQLYHSPFFGDESNKPILLPNESQS
             1450      1460      1470      1480      1490      1500

    1460      1470      1480      1490      1500      1510         
pF1KSD FERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELKD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELKD
             1510      1520      1530      1540      1550      1560

    1520      1530      1540      1550      1560      1570         
pF1KSD CQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFV
             1570      1580      1590      1600      1610      1620

    1580      1590      1600      1610      1620      1630         
pF1KSD SIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDR
             1630      1640      1650      1660      1670      1680

    1640      1650      1660      1670      1680      1690         
pF1KSD NLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNPSLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNPSLP
             1690      1700      1710      1720      1730      1740

    1700      1710      1720      1730      1740
pF1KSD LVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSVEDFTEFV
       ::::::::::::::::::::::::::::::::         
XP_011 LVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSVEDFTEFV
             1750      1760      1770      1780 

>>XP_016879105 (OMIM: 191092,606690,613254) PREDICTED: t  (1763 aa)
 initn: 8033 init1: 8033 opt: 8033  Z-score: 6547.0  bits: 1224.5 E(85289):    0
Smith-Waterman score: 11408; 98.7% identity (98.7% similar) in 1763 aa overlap (1-1740:1-1763)

               10        20        30        40        50        60
pF1KSD MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KSD EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KSD PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KSD SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KSD GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KSD VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KSD DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KSD VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KSD RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKRIQTSLTSASLGSAD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKRIQTSLTSASLGSAD
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KSD ENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGN
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KSD KLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGA
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KSD RDRVRSMSGGHGLRVGALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RDRVRSMSGGHGLRVGALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLA
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KSD AYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEH
             1150      1160      1170      1180      1190      1200

             1210      1220                             1230       
pF1KSD RDTALYKSLSVPAASTAKPPPLPRSNT-----------------------DSAVVMEEGS
       :::::::::::::::::::::::::::                       ::::::::::
XP_016 RDTALYKSLSVPAASTAKPPPLPRSNTVASFSSLYQSSCQGQLHRSVSWADSAVVMEEGS
             1210      1220      1230      1240      1250      1260

      1240      1250      1260      1270      1280      1290       
pF1KSD PGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVS
             1270      1280      1290      1300      1310      1320

      1300      1310      1320      1330      1340      1350       
pF1KSD SEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLD
             1330      1340      1350      1360      1370      1380

      1360      1370      1380      1390      1400      1410       
pF1KSD GESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRA
             1390      1400      1410      1420      1430      1440

      1420      1430      1440      1450      1460      1470       
pF1KSD TASNAEKVPGINPSFVFLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TASNAEKVPGINPSFVFLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHK
             1450      1460      1470      1480      1490      1500

      1480      1490      1500      1510      1520      1530       
pF1KSD IAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDG
             1510      1520      1530      1540      1550      1560

      1540      1550      1560      1570      1580      1590       
pF1KSD QFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKG
             1570      1580      1590      1600      1610      1620

      1600      1610      1620      1630      1640      1650       
pF1KSD QFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQ
             1630      1640      1650      1660      1670      1680

      1660      1670      1680      1690      1700      1710       
pF1KSD VHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEP
             1690      1700      1710      1720      1730      1740

      1720      1730      1740
pF1KSD TPGYEVGQRKRLISSVEDFTEFV
       :::::::::::::::::::::::
XP_016 TPGYEVGQRKRLISSVEDFTEFV
             1750      1760   

>>XP_011520941 (OMIM: 191092,606690,613254) PREDICTED: t  (1782 aa)
 initn: 11436 init1: 6221 opt: 8025  Z-score: 6540.5  bits: 1223.3 E(85289):    0
Smith-Waterman score: 11299; 97.6% identity (97.6% similar) in 1772 aa overlap (1-1730:1-1772)

               10        20        30        40        50        60
pF1KSD MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KSD EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KSD PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KSD SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KSD GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KSD VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KSD DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KSD VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC
              850       860       870       880       890       900

              910       920       930       940        950         
pF1KSD RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPK-RIQTSLTSASLGSA
       ::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::::
XP_011 RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSRIQTSLTSASLGSA
              910       920       930       940       950       960

     960       970       980       990      1000      1010         
pF1KSD DENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVG
              970       980       990      1000      1010      1020

    1020      1030      1040      1050      1060      1070         
pF1KSD NKLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NKLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRG
             1030      1040      1050      1060      1070      1080

    1080      1090      1100      1110      1120      1130         
pF1KSD ARDRVRSMSGGHGLRVGALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ARDRVRSMSGGHGLRVGALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNL
             1090      1100      1110      1120      1130      1140

    1140      1150      1160      1170      1180      1190         
pF1KSD AAYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKE
             1150      1160      1170      1180      1190      1200

    1200      1210      1220                                       
pF1KSD HRDTALYKSLSVPAASTAKPPPLPRSNT--------------------------------
       ::::::::::::::::::::::::::::                                
XP_011 HRDTALYKSLSVPAASTAKPPPLPRSNTVASFSSLYQSSCQGQLHRSVSWAGIASQREAV
             1210      1220      1230      1240      1250      1260

               1230      1240      1250      1260      1270        
pF1KSD ---------DSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEK
                :::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GCRAPLCLIDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEK
             1270      1280      1290      1300      1310      1320

     1280      1290      1300      1310      1320      1330        
pF1KSD SLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGDKA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGDKA
             1330      1340      1350      1360      1370      1380

     1340      1350      1360      1370      1380      1390        
pF1KSD DVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTISD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTISD
             1390      1400      1410      1420      1430      1440

     1400      1410      1420      1430      1440      1450        
pF1KSD SAPSRRGKRVERDALKSRATASNAEKVPGINPSFVFLQLYHSPFFGDESNKPILLPNESQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SAPSRRGKRVERDALKSRATASNAEKVPGINPSFVFLQLYHSPFFGDESNKPILLPNESQ
             1450      1460      1470      1480      1490      1500

     1460      1470      1480      1490      1500      1510        
pF1KSD SFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELK
             1510      1520      1530      1540      1550      1560

     1520      1530      1540      1550      1560      1570        
pF1KSD DCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDF
             1570      1580      1590      1600      1610      1620

     1580      1590      1600      1610      1620      1630        
pF1KSD VSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTSVAKIVSD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTSVAKIVSD
             1630      1640      1650      1660      1670      1680

     1640      1650      1660      1670      1680      1690        
pF1KSD RNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNPSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNPSL
             1690      1700      1710      1720      1730      1740

     1700      1710      1720      1730      1740
pF1KSD PLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSVEDFTEFV
       ::::::::::::::::::::::::::::::::          
XP_011 PLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSVEDFTEFV
             1750      1760      1770      1780  

>>XP_005255586 (OMIM: 191092,606690,613254) PREDICTED: t  (1764 aa)
 initn: 9639 init1: 6221 opt: 8021  Z-score: 6537.3  bits: 1222.7 E(85289):    0
Smith-Waterman score: 11396; 98.6% identity (98.6% similar) in 1764 aa overlap (1-1740:1-1764)

               10        20        30        40        50        60
pF1KSD MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KSD EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KSD PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KSD SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KSD GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KSD VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KSD DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KSD VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC
              850       860       870       880       890       900

              910       920       930       940        950         
pF1KSD RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPK-RIQTSLTSASLGSA
       ::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::::
XP_005 RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSRIQTSLTSASLGSA
              910       920       930       940       950       960

     960       970       980       990      1000      1010         
pF1KSD DENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVG
              970       980       990      1000      1010      1020

    1020      1030      1040      1050      1060      1070         
pF1KSD NKLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NKLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRG
             1030      1040      1050      1060      1070      1080

    1080      1090      1100      1110      1120      1130         
pF1KSD ARDRVRSMSGGHGLRVGALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ARDRVRSMSGGHGLRVGALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNL
             1090      1100      1110      1120      1130      1140

    1140      1150      1160      1170      1180      1190         
pF1KSD AAYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKE
             1150      1160      1170      1180      1190      1200

    1200      1210      1220                             1230      
pF1KSD HRDTALYKSLSVPAASTAKPPPLPRSNT-----------------------DSAVVMEEG
       ::::::::::::::::::::::::::::                       :::::::::
XP_005 HRDTALYKSLSVPAASTAKPPPLPRSNTVASFSSLYQSSCQGQLHRSVSWADSAVVMEEG
             1210      1220      1230      1240      1250      1260

       1240      1250      1260      1270      1280      1290      
pF1KSD SPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVV
             1270      1280      1290      1300      1310      1320

       1300      1310      1320      1330      1340      1350      
pF1KSD SSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTL
             1330      1340      1350      1360      1370      1380

       1360      1370      1380      1390      1400      1410      
pF1KSD DGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSR
             1390      1400      1410      1420      1430      1440

       1420      1430      1440      1450      1460      1470      
pF1KSD ATASNAEKVPGINPSFVFLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ATASNAEKVPGINPSFVFLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTH
             1450      1460      1470      1480      1490      1500

       1480      1490      1500      1510      1520      1530      
pF1KSD KIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGED
             1510      1520      1530      1540      1550      1560

       1540      1550      1560      1570      1580      1590      
pF1KSD GQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIK
             1570      1580      1590      1600      1610      1620

       1600      1610      1620      1630      1640      1650      
pF1KSD GQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMAS
             1630      1640      1650      1660      1670      1680

       1660      1670      1680      1690      1700      1710      
pF1KSD QVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAE
             1690      1700      1710      1720      1730      1740

       1720      1730      1740
pF1KSD PTPGYEVGQRKRLISSVEDFTEFV
       ::::::::::::::::::::::::
XP_005 PTPGYEVGQRKRLISSVEDFTEFV
             1750      1760    




1740 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 08:06:14 2016 done: Thu Nov  3 08:06:17 2016
 Total Scan time: 22.530 Total Display time:  1.180

Function used was FASTA [36.3.4 Apr, 2011]
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