Result of FASTA (omim) for pF1KSDA1133
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KSDA1133, 836 aa
  1>>>pF1KSDA1133 836 - 836 aa - 836 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 8.5675+/-0.000344; mu= 6.8386+/- 0.021
 mean_var=222.4794+/-44.946, 0's: 0 Z-trim(122.1): 122  B-trim: 283 in 1/55
 Lambda= 0.085986
 statistics sampled from 39645 (39787) to 39645 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.782), E-opt: 0.2 (0.466), width:  16
 Scan time: 14.470

The best scores are:                                      opt bits E(85289)
NP_115549 (OMIM: 612062) E3 ubiquitin-protein liga ( 836) 5876 742.3 2.1e-213
XP_011528737 (OMIM: 612062) PREDICTED: E3 ubiquiti ( 841) 5876 742.3 2.1e-213
XP_011528739 (OMIM: 612062) PREDICTED: E3 ubiquiti ( 841) 5876 742.3 2.1e-213
XP_011528740 (OMIM: 612062) PREDICTED: E3 ubiquiti ( 841) 5876 742.3 2.1e-213
XP_011528738 (OMIM: 612062) PREDICTED: E3 ubiquiti ( 841) 5876 742.3 2.1e-213
XP_016884479 (OMIM: 612062) PREDICTED: E3 ubiquiti ( 841) 5876 742.3 2.1e-213
NP_001193927 (OMIM: 612062) E3 ubiquitin-protein l ( 936) 5876 742.3 2.3e-213
XP_016880289 (OMIM: 612482,617108) PREDICTED: E3 u ( 869)  686 98.5 1.4e-19
XP_011523257 (OMIM: 612482,617108) PREDICTED: E3 u ( 869)  686 98.5 1.4e-19
NP_060233 (OMIM: 612482,617108) E3 ubiquitin-prote ( 783)  662 95.4   1e-18
NP_001292473 (OMIM: 612482,617108) E3 ubiquitin-pr ( 783)  662 95.4   1e-18
XP_011523258 (OMIM: 612482,617108) PREDICTED: E3 u ( 742)  531 79.2 7.8e-14
NP_001292474 (OMIM: 612482,617108) E3 ubiquitin-pr ( 656)  507 76.2 5.6e-13
NP_919445 (OMIM: 300439) E3 ubiquitin-protein liga ( 428)  263 45.7 0.00053
NP_078815 (OMIM: 300439) E3 ubiquitin-protein liga ( 402)  255 44.7   0.001
XP_016879917 (OMIM: 610431) PREDICTED: E3 ubiquiti ( 227)  247 43.5  0.0013
NP_001307292 (OMIM: 610431) E3 ubiquitin-protein l ( 315)  247 43.6  0.0017
NP_001307294 (OMIM: 610431) E3 ubiquitin-protein l ( 315)  247 43.6  0.0017
NP_001307291 (OMIM: 610431) E3 ubiquitin-protein l ( 315)  247 43.6  0.0017
NP_001307293 (OMIM: 610431) E3 ubiquitin-protein l ( 315)  247 43.6  0.0017
NP_001307286 (OMIM: 610431) E3 ubiquitin-protein l ( 350)  247 43.7  0.0018
NP_056343 (OMIM: 610431) E3 ubiquitin-protein liga ( 350)  247 43.7  0.0018
NP_001307290 (OMIM: 610431) E3 ubiquitin-protein l ( 350)  247 43.7  0.0018
NP_001307287 (OMIM: 610431) E3 ubiquitin-protein l ( 350)  247 43.7  0.0018
NP_001307285 (OMIM: 610431) E3 ubiquitin-protein l ( 350)  247 43.7  0.0018
NP_001307288 (OMIM: 610431) E3 ubiquitin-protein l ( 350)  247 43.7  0.0018
NP_001307289 (OMIM: 610431) E3 ubiquitin-protein l ( 350)  247 43.7  0.0018
XP_016879916 (OMIM: 610431) PREDICTED: E3 ubiquiti ( 350)  247 43.7  0.0018
XP_016861150 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 193)  239 42.4  0.0023
XP_016861149 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 250)  239 42.5  0.0028
XP_016861148 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 262)  239 42.6  0.0029
XP_011510678 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 262)  239 42.6  0.0029
XP_005247149 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 262)  239 42.6  0.0029
XP_016861147 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 262)  239 42.6  0.0029
XP_016861145 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 262)  239 42.6  0.0029
XP_016861146 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 262)  239 42.6  0.0029
XP_011510675 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 381)  239 42.7  0.0038
XP_016861143 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 381)  239 42.7  0.0038
XP_011510676 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 381)  239 42.7  0.0038
NP_899237 (OMIM: 609247) E3 ubiquitin-protein liga ( 381)  239 42.7  0.0038
XP_016861144 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 381)  239 42.7  0.0038
NP_009213 (OMIM: 609247) E3 ubiquitin-protein liga ( 381)  239 42.7  0.0038


>>NP_115549 (OMIM: 612062) E3 ubiquitin-protein ligase Z  (836 aa)
 initn: 5876 init1: 5876 opt: 5876  Z-score: 3952.2  bits: 742.3 E(85289): 2.1e-213
Smith-Waterman score: 5876; 100.0% identity (100.0% similar) in 836 aa overlap (1-836:1-836)

               10        20        30        40        50        60
pF1KSD MHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVIFDVSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 MHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVIFDVSE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD NPEAIDQLNQGSEDPLKRPVVYVKGADAIKLMNIVNKQKVARARIQHRPPRQPTEYFDMG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 NPEAIDQLNQGSEDPLKRPVVYVKGADAIKLMNIVNKQKVARARIQHRPPRQPTEYFDMG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD IFLAFFVVVSLVCLILLVKIKLKQRRSQNSMNRLAVQALEKMETRKFNSKSKGRREGSCG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 IFLAFFVVVSLVCLILLVKIKLKQRRSQNSMNRLAVQALEKMETRKFNSKSKGRREGSCG
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD ALDTLSSSSTSDCAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRHNIIEQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 ALDTLSSSSTSDCAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRHNIIEQ
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD KGNPSAVCVETSNLSRGRQQRVTLPVHYPGRVHRTNAIPAYPTRTSMDSHGNPVTLLTMD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 KGNPSAVCVETSNLSRGRQQRVTLPVHYPGRVHRTNAIPAYPTRTSMDSHGNPVTLLTMD
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD RHGEQSLYSPQTPAYIRSYPPLHLDHSLAAHRCGLEHRAYSPAHPFRRPKLSGRSFSKAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 RHGEQSLYSPQTPAYIRSYPPLHLDHSLAAHRCGLEHRAYSPAHPFRRPKLSGRSFSKAA
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD CFSQYETMYQHYYFQGLSYPEQEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHVAPPSH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 CFSQYETMYQHYYFQGLSYPEQEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHVAPPSH
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD LESGSTSSFSCYHGHRSVCSGYLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVSNQGVY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 LESGSTSSFSCYHGHRSVCSGYLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVSNQGVY
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KSD GSCSTFRSSLSSDYDPFIYRSRSPCRASEAGGSGSSGRGPALCFEGSPPPEELPAVHSHG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 GSCSTFRSSLSSDYDPFIYRSRSPCRASEAGGSGSSGRGPALCFEGSPPPEELPAVHSHG
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KSD AGRGEPWPGPASPSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAPDLRRT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 AGRGEPWPGPASPSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAPDLRRT
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KSD WKGGHELPSCACCCEPQPSPAGPSAGAAGSSTLFLGPHLYEGSGPAGGEPQSGSSQGLYG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 WKGGHELPSCACCCEPQPSPAGPSAGAAGSSTLFLGPHLYEGSGPAGGEPQSGSSQGLYG
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KSD LHPDHLPRTDGVKYEGLPCCFYEEKQVARGGGGGSGCYTEDYSVSVQYTLTEEPPPGCYP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 LHPDHLPRTDGVKYEGLPCCFYEEKQVARGGGGGSGCYTEDYSVSVQYTLTEEPPPGCYP
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KSD GARDLSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTPRPHRGLGATREEERAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 GARDLSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTPRPHRGLGATREEERAL
              730       740       750       760       770       780

              790       800       810       820       830      
pF1KSD CCQARALLRPGCPPEEAGAVRANFPSALQDTQESSTTATEAAGPRSHSADSSSPGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 CCQARALLRPGCPPEEAGAVRANFPSALQDTQESSTTATEAAGPRSHSADSSSPGA
              790       800       810       820       830      

>>XP_011528737 (OMIM: 612062) PREDICTED: E3 ubiquitin-pr  (841 aa)
 initn: 5876 init1: 5876 opt: 5876  Z-score: 3952.1  bits: 742.3 E(85289): 2.1e-213
Smith-Waterman score: 5876; 100.0% identity (100.0% similar) in 836 aa overlap (1-836:6-841)

                    10        20        30        40        50     
pF1KSD      MHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVI
            :::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MITLKMHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVI
               10        20        30        40        50        60

          60        70        80        90       100       110     
pF1KSD FDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIKLMNIVNKQKVARARIQHRPPRQPTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIKLMNIVNKQKVARARIQHRPPRQPTE
               70        80        90       100       110       120

         120       130       140       150       160       170     
pF1KSD YFDMGIFLAFFVVVSLVCLILLVKIKLKQRRSQNSMNRLAVQALEKMETRKFNSKSKGRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YFDMGIFLAFFVVVSLVCLILLVKIKLKQRRSQNSMNRLAVQALEKMETRKFNSKSKGRR
              130       140       150       160       170       180

         180       190       200       210       220       230     
pF1KSD EGSCGALDTLSSSSTSDCAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EGSCGALDTLSSSSTSDCAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRH
              190       200       210       220       230       240

         240       250       260       270       280       290     
pF1KSD NIIEQKGNPSAVCVETSNLSRGRQQRVTLPVHYPGRVHRTNAIPAYPTRTSMDSHGNPVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NIIEQKGNPSAVCVETSNLSRGRQQRVTLPVHYPGRVHRTNAIPAYPTRTSMDSHGNPVT
              250       260       270       280       290       300

         300       310       320       330       340       350     
pF1KSD LLTMDRHGEQSLYSPQTPAYIRSYPPLHLDHSLAAHRCGLEHRAYSPAHPFRRPKLSGRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLTMDRHGEQSLYSPQTPAYIRSYPPLHLDHSLAAHRCGLEHRAYSPAHPFRRPKLSGRS
              310       320       330       340       350       360

         360       370       380       390       400       410     
pF1KSD FSKAACFSQYETMYQHYYFQGLSYPEQEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSKAACFSQYETMYQHYYFQGLSYPEQEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHV
              370       380       390       400       410       420

         420       430       440       450       460       470     
pF1KSD APPSHLESGSTSSFSCYHGHRSVCSGYLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APPSHLESGSTSSFSCYHGHRSVCSGYLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVS
              430       440       450       460       470       480

         480       490       500       510       520       530     
pF1KSD NQGVYGSCSTFRSSLSSDYDPFIYRSRSPCRASEAGGSGSSGRGPALCFEGSPPPEELPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NQGVYGSCSTFRSSLSSDYDPFIYRSRSPCRASEAGGSGSSGRGPALCFEGSPPPEELPA
              490       500       510       520       530       540

         540       550       560       570       580       590     
pF1KSD VHSHGAGRGEPWPGPASPSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VHSHGAGRGEPWPGPASPSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAP
              550       560       570       580       590       600

         600       610       620       630       640       650     
pF1KSD DLRRTWKGGHELPSCACCCEPQPSPAGPSAGAAGSSTLFLGPHLYEGSGPAGGEPQSGSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLRRTWKGGHELPSCACCCEPQPSPAGPSAGAAGSSTLFLGPHLYEGSGPAGGEPQSGSS
              610       620       630       640       650       660

         660       670       680       690       700       710     
pF1KSD QGLYGLHPDHLPRTDGVKYEGLPCCFYEEKQVARGGGGGSGCYTEDYSVSVQYTLTEEPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QGLYGLHPDHLPRTDGVKYEGLPCCFYEEKQVARGGGGGSGCYTEDYSVSVQYTLTEEPP
              670       680       690       700       710       720

         720       730       740       750       760       770     
pF1KSD PGCYPGARDLSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTPRPHRGLGATRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGCYPGARDLSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTPRPHRGLGATRE
              730       740       750       760       770       780

         780       790       800       810       820       830     
pF1KSD EERALCCQARALLRPGCPPEEAGAVRANFPSALQDTQESSTTATEAAGPRSHSADSSSPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EERALCCQARALLRPGCPPEEAGAVRANFPSALQDTQESSTTATEAAGPRSHSADSSSPG
              790       800       810       820       830       840

        
pF1KSD A
       :
XP_011 A
        

>>XP_011528739 (OMIM: 612062) PREDICTED: E3 ubiquitin-pr  (841 aa)
 initn: 5876 init1: 5876 opt: 5876  Z-score: 3952.1  bits: 742.3 E(85289): 2.1e-213
Smith-Waterman score: 5876; 100.0% identity (100.0% similar) in 836 aa overlap (1-836:6-841)

                    10        20        30        40        50     
pF1KSD      MHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVI
            :::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MITLKMHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVI
               10        20        30        40        50        60

          60        70        80        90       100       110     
pF1KSD FDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIKLMNIVNKQKVARARIQHRPPRQPTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIKLMNIVNKQKVARARIQHRPPRQPTE
               70        80        90       100       110       120

         120       130       140       150       160       170     
pF1KSD YFDMGIFLAFFVVVSLVCLILLVKIKLKQRRSQNSMNRLAVQALEKMETRKFNSKSKGRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YFDMGIFLAFFVVVSLVCLILLVKIKLKQRRSQNSMNRLAVQALEKMETRKFNSKSKGRR
              130       140       150       160       170       180

         180       190       200       210       220       230     
pF1KSD EGSCGALDTLSSSSTSDCAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EGSCGALDTLSSSSTSDCAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRH
              190       200       210       220       230       240

         240       250       260       270       280       290     
pF1KSD NIIEQKGNPSAVCVETSNLSRGRQQRVTLPVHYPGRVHRTNAIPAYPTRTSMDSHGNPVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NIIEQKGNPSAVCVETSNLSRGRQQRVTLPVHYPGRVHRTNAIPAYPTRTSMDSHGNPVT
              250       260       270       280       290       300

         300       310       320       330       340       350     
pF1KSD LLTMDRHGEQSLYSPQTPAYIRSYPPLHLDHSLAAHRCGLEHRAYSPAHPFRRPKLSGRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLTMDRHGEQSLYSPQTPAYIRSYPPLHLDHSLAAHRCGLEHRAYSPAHPFRRPKLSGRS
              310       320       330       340       350       360

         360       370       380       390       400       410     
pF1KSD FSKAACFSQYETMYQHYYFQGLSYPEQEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSKAACFSQYETMYQHYYFQGLSYPEQEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHV
              370       380       390       400       410       420

         420       430       440       450       460       470     
pF1KSD APPSHLESGSTSSFSCYHGHRSVCSGYLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APPSHLESGSTSSFSCYHGHRSVCSGYLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVS
              430       440       450       460       470       480

         480       490       500       510       520       530     
pF1KSD NQGVYGSCSTFRSSLSSDYDPFIYRSRSPCRASEAGGSGSSGRGPALCFEGSPPPEELPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NQGVYGSCSTFRSSLSSDYDPFIYRSRSPCRASEAGGSGSSGRGPALCFEGSPPPEELPA
              490       500       510       520       530       540

         540       550       560       570       580       590     
pF1KSD VHSHGAGRGEPWPGPASPSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VHSHGAGRGEPWPGPASPSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAP
              550       560       570       580       590       600

         600       610       620       630       640       650     
pF1KSD DLRRTWKGGHELPSCACCCEPQPSPAGPSAGAAGSSTLFLGPHLYEGSGPAGGEPQSGSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLRRTWKGGHELPSCACCCEPQPSPAGPSAGAAGSSTLFLGPHLYEGSGPAGGEPQSGSS
              610       620       630       640       650       660

         660       670       680       690       700       710     
pF1KSD QGLYGLHPDHLPRTDGVKYEGLPCCFYEEKQVARGGGGGSGCYTEDYSVSVQYTLTEEPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QGLYGLHPDHLPRTDGVKYEGLPCCFYEEKQVARGGGGGSGCYTEDYSVSVQYTLTEEPP
              670       680       690       700       710       720

         720       730       740       750       760       770     
pF1KSD PGCYPGARDLSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTPRPHRGLGATRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGCYPGARDLSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTPRPHRGLGATRE
              730       740       750       760       770       780

         780       790       800       810       820       830     
pF1KSD EERALCCQARALLRPGCPPEEAGAVRANFPSALQDTQESSTTATEAAGPRSHSADSSSPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EERALCCQARALLRPGCPPEEAGAVRANFPSALQDTQESSTTATEAAGPRSHSADSSSPG
              790       800       810       820       830       840

        
pF1KSD A
       :
XP_011 A
        

>>XP_011528740 (OMIM: 612062) PREDICTED: E3 ubiquitin-pr  (841 aa)
 initn: 5876 init1: 5876 opt: 5876  Z-score: 3952.1  bits: 742.3 E(85289): 2.1e-213
Smith-Waterman score: 5876; 100.0% identity (100.0% similar) in 836 aa overlap (1-836:6-841)

                    10        20        30        40        50     
pF1KSD      MHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVI
            :::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MITLKMHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVI
               10        20        30        40        50        60

          60        70        80        90       100       110     
pF1KSD FDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIKLMNIVNKQKVARARIQHRPPRQPTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIKLMNIVNKQKVARARIQHRPPRQPTE
               70        80        90       100       110       120

         120       130       140       150       160       170     
pF1KSD YFDMGIFLAFFVVVSLVCLILLVKIKLKQRRSQNSMNRLAVQALEKMETRKFNSKSKGRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YFDMGIFLAFFVVVSLVCLILLVKIKLKQRRSQNSMNRLAVQALEKMETRKFNSKSKGRR
              130       140       150       160       170       180

         180       190       200       210       220       230     
pF1KSD EGSCGALDTLSSSSTSDCAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EGSCGALDTLSSSSTSDCAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRH
              190       200       210       220       230       240

         240       250       260       270       280       290     
pF1KSD NIIEQKGNPSAVCVETSNLSRGRQQRVTLPVHYPGRVHRTNAIPAYPTRTSMDSHGNPVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NIIEQKGNPSAVCVETSNLSRGRQQRVTLPVHYPGRVHRTNAIPAYPTRTSMDSHGNPVT
              250       260       270       280       290       300

         300       310       320       330       340       350     
pF1KSD LLTMDRHGEQSLYSPQTPAYIRSYPPLHLDHSLAAHRCGLEHRAYSPAHPFRRPKLSGRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLTMDRHGEQSLYSPQTPAYIRSYPPLHLDHSLAAHRCGLEHRAYSPAHPFRRPKLSGRS
              310       320       330       340       350       360

         360       370       380       390       400       410     
pF1KSD FSKAACFSQYETMYQHYYFQGLSYPEQEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSKAACFSQYETMYQHYYFQGLSYPEQEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHV
              370       380       390       400       410       420

         420       430       440       450       460       470     
pF1KSD APPSHLESGSTSSFSCYHGHRSVCSGYLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APPSHLESGSTSSFSCYHGHRSVCSGYLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVS
              430       440       450       460       470       480

         480       490       500       510       520       530     
pF1KSD NQGVYGSCSTFRSSLSSDYDPFIYRSRSPCRASEAGGSGSSGRGPALCFEGSPPPEELPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NQGVYGSCSTFRSSLSSDYDPFIYRSRSPCRASEAGGSGSSGRGPALCFEGSPPPEELPA
              490       500       510       520       530       540

         540       550       560       570       580       590     
pF1KSD VHSHGAGRGEPWPGPASPSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VHSHGAGRGEPWPGPASPSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAP
              550       560       570       580       590       600

         600       610       620       630       640       650     
pF1KSD DLRRTWKGGHELPSCACCCEPQPSPAGPSAGAAGSSTLFLGPHLYEGSGPAGGEPQSGSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLRRTWKGGHELPSCACCCEPQPSPAGPSAGAAGSSTLFLGPHLYEGSGPAGGEPQSGSS
              610       620       630       640       650       660

         660       670       680       690       700       710     
pF1KSD QGLYGLHPDHLPRTDGVKYEGLPCCFYEEKQVARGGGGGSGCYTEDYSVSVQYTLTEEPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QGLYGLHPDHLPRTDGVKYEGLPCCFYEEKQVARGGGGGSGCYTEDYSVSVQYTLTEEPP
              670       680       690       700       710       720

         720       730       740       750       760       770     
pF1KSD PGCYPGARDLSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTPRPHRGLGATRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGCYPGARDLSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTPRPHRGLGATRE
              730       740       750       760       770       780

         780       790       800       810       820       830     
pF1KSD EERALCCQARALLRPGCPPEEAGAVRANFPSALQDTQESSTTATEAAGPRSHSADSSSPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EERALCCQARALLRPGCPPEEAGAVRANFPSALQDTQESSTTATEAAGPRSHSADSSSPG
              790       800       810       820       830       840

        
pF1KSD A
       :
XP_011 A
        

>>XP_011528738 (OMIM: 612062) PREDICTED: E3 ubiquitin-pr  (841 aa)
 initn: 5876 init1: 5876 opt: 5876  Z-score: 3952.1  bits: 742.3 E(85289): 2.1e-213
Smith-Waterman score: 5876; 100.0% identity (100.0% similar) in 836 aa overlap (1-836:6-841)

                    10        20        30        40        50     
pF1KSD      MHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVI
            :::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MITLKMHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVI
               10        20        30        40        50        60

          60        70        80        90       100       110     
pF1KSD FDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIKLMNIVNKQKVARARIQHRPPRQPTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIKLMNIVNKQKVARARIQHRPPRQPTE
               70        80        90       100       110       120

         120       130       140       150       160       170     
pF1KSD YFDMGIFLAFFVVVSLVCLILLVKIKLKQRRSQNSMNRLAVQALEKMETRKFNSKSKGRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YFDMGIFLAFFVVVSLVCLILLVKIKLKQRRSQNSMNRLAVQALEKMETRKFNSKSKGRR
              130       140       150       160       170       180

         180       190       200       210       220       230     
pF1KSD EGSCGALDTLSSSSTSDCAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EGSCGALDTLSSSSTSDCAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRH
              190       200       210       220       230       240

         240       250       260       270       280       290     
pF1KSD NIIEQKGNPSAVCVETSNLSRGRQQRVTLPVHYPGRVHRTNAIPAYPTRTSMDSHGNPVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NIIEQKGNPSAVCVETSNLSRGRQQRVTLPVHYPGRVHRTNAIPAYPTRTSMDSHGNPVT
              250       260       270       280       290       300

         300       310       320       330       340       350     
pF1KSD LLTMDRHGEQSLYSPQTPAYIRSYPPLHLDHSLAAHRCGLEHRAYSPAHPFRRPKLSGRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLTMDRHGEQSLYSPQTPAYIRSYPPLHLDHSLAAHRCGLEHRAYSPAHPFRRPKLSGRS
              310       320       330       340       350       360

         360       370       380       390       400       410     
pF1KSD FSKAACFSQYETMYQHYYFQGLSYPEQEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSKAACFSQYETMYQHYYFQGLSYPEQEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHV
              370       380       390       400       410       420

         420       430       440       450       460       470     
pF1KSD APPSHLESGSTSSFSCYHGHRSVCSGYLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APPSHLESGSTSSFSCYHGHRSVCSGYLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVS
              430       440       450       460       470       480

         480       490       500       510       520       530     
pF1KSD NQGVYGSCSTFRSSLSSDYDPFIYRSRSPCRASEAGGSGSSGRGPALCFEGSPPPEELPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NQGVYGSCSTFRSSLSSDYDPFIYRSRSPCRASEAGGSGSSGRGPALCFEGSPPPEELPA
              490       500       510       520       530       540

         540       550       560       570       580       590     
pF1KSD VHSHGAGRGEPWPGPASPSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VHSHGAGRGEPWPGPASPSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAP
              550       560       570       580       590       600

         600       610       620       630       640       650     
pF1KSD DLRRTWKGGHELPSCACCCEPQPSPAGPSAGAAGSSTLFLGPHLYEGSGPAGGEPQSGSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLRRTWKGGHELPSCACCCEPQPSPAGPSAGAAGSSTLFLGPHLYEGSGPAGGEPQSGSS
              610       620       630       640       650       660

         660       670       680       690       700       710     
pF1KSD QGLYGLHPDHLPRTDGVKYEGLPCCFYEEKQVARGGGGGSGCYTEDYSVSVQYTLTEEPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QGLYGLHPDHLPRTDGVKYEGLPCCFYEEKQVARGGGGGSGCYTEDYSVSVQYTLTEEPP
              670       680       690       700       710       720

         720       730       740       750       760       770     
pF1KSD PGCYPGARDLSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTPRPHRGLGATRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGCYPGARDLSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTPRPHRGLGATRE
              730       740       750       760       770       780

         780       790       800       810       820       830     
pF1KSD EERALCCQARALLRPGCPPEEAGAVRANFPSALQDTQESSTTATEAAGPRSHSADSSSPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EERALCCQARALLRPGCPPEEAGAVRANFPSALQDTQESSTTATEAAGPRSHSADSSSPG
              790       800       810       820       830       840

        
pF1KSD A
       :
XP_011 A
        

>>XP_016884479 (OMIM: 612062) PREDICTED: E3 ubiquitin-pr  (841 aa)
 initn: 5876 init1: 5876 opt: 5876  Z-score: 3952.1  bits: 742.3 E(85289): 2.1e-213
Smith-Waterman score: 5876; 100.0% identity (100.0% similar) in 836 aa overlap (1-836:6-841)

                    10        20        30        40        50     
pF1KSD      MHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVI
            :::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MITLKMHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVI
               10        20        30        40        50        60

          60        70        80        90       100       110     
pF1KSD FDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIKLMNIVNKQKVARARIQHRPPRQPTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIKLMNIVNKQKVARARIQHRPPRQPTE
               70        80        90       100       110       120

         120       130       140       150       160       170     
pF1KSD YFDMGIFLAFFVVVSLVCLILLVKIKLKQRRSQNSMNRLAVQALEKMETRKFNSKSKGRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YFDMGIFLAFFVVVSLVCLILLVKIKLKQRRSQNSMNRLAVQALEKMETRKFNSKSKGRR
              130       140       150       160       170       180

         180       190       200       210       220       230     
pF1KSD EGSCGALDTLSSSSTSDCAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGSCGALDTLSSSSTSDCAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRH
              190       200       210       220       230       240

         240       250       260       270       280       290     
pF1KSD NIIEQKGNPSAVCVETSNLSRGRQQRVTLPVHYPGRVHRTNAIPAYPTRTSMDSHGNPVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NIIEQKGNPSAVCVETSNLSRGRQQRVTLPVHYPGRVHRTNAIPAYPTRTSMDSHGNPVT
              250       260       270       280       290       300

         300       310       320       330       340       350     
pF1KSD LLTMDRHGEQSLYSPQTPAYIRSYPPLHLDHSLAAHRCGLEHRAYSPAHPFRRPKLSGRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLTMDRHGEQSLYSPQTPAYIRSYPPLHLDHSLAAHRCGLEHRAYSPAHPFRRPKLSGRS
              310       320       330       340       350       360

         360       370       380       390       400       410     
pF1KSD FSKAACFSQYETMYQHYYFQGLSYPEQEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FSKAACFSQYETMYQHYYFQGLSYPEQEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHV
              370       380       390       400       410       420

         420       430       440       450       460       470     
pF1KSD APPSHLESGSTSSFSCYHGHRSVCSGYLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APPSHLESGSTSSFSCYHGHRSVCSGYLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVS
              430       440       450       460       470       480

         480       490       500       510       520       530     
pF1KSD NQGVYGSCSTFRSSLSSDYDPFIYRSRSPCRASEAGGSGSSGRGPALCFEGSPPPEELPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NQGVYGSCSTFRSSLSSDYDPFIYRSRSPCRASEAGGSGSSGRGPALCFEGSPPPEELPA
              490       500       510       520       530       540

         540       550       560       570       580       590     
pF1KSD VHSHGAGRGEPWPGPASPSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VHSHGAGRGEPWPGPASPSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAP
              550       560       570       580       590       600

         600       610       620       630       640       650     
pF1KSD DLRRTWKGGHELPSCACCCEPQPSPAGPSAGAAGSSTLFLGPHLYEGSGPAGGEPQSGSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLRRTWKGGHELPSCACCCEPQPSPAGPSAGAAGSSTLFLGPHLYEGSGPAGGEPQSGSS
              610       620       630       640       650       660

         660       670       680       690       700       710     
pF1KSD QGLYGLHPDHLPRTDGVKYEGLPCCFYEEKQVARGGGGGSGCYTEDYSVSVQYTLTEEPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QGLYGLHPDHLPRTDGVKYEGLPCCFYEEKQVARGGGGGSGCYTEDYSVSVQYTLTEEPP
              670       680       690       700       710       720

         720       730       740       750       760       770     
pF1KSD PGCYPGARDLSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTPRPHRGLGATRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGCYPGARDLSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTPRPHRGLGATRE
              730       740       750       760       770       780

         780       790       800       810       820       830     
pF1KSD EERALCCQARALLRPGCPPEEAGAVRANFPSALQDTQESSTTATEAAGPRSHSADSSSPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EERALCCQARALLRPGCPPEEAGAVRANFPSALQDTQESSTTATEAAGPRSHSADSSSPG
              790       800       810       820       830       840

        
pF1KSD A
       :
XP_016 A
        

>>NP_001193927 (OMIM: 612062) E3 ubiquitin-protein ligas  (936 aa)
 initn: 5876 init1: 5876 opt: 5876  Z-score: 3951.5  bits: 742.3 E(85289): 2.3e-213
Smith-Waterman score: 5876; 100.0% identity (100.0% similar) in 836 aa overlap (1-836:101-936)

                                             10        20        30
pF1KSD                               MHPLGLCNNNDEEDLYEYGWVGVVKLEQPE
                                     ::::::::::::::::::::::::::::::
NP_001 SGDYTTYTTGLTGRFSRAGATLSAEGEIVQMHPLGLCNNNDEEDLYEYGWVGVVKLEQPE
               80        90       100       110       120       130

               40        50        60        70        80        90
pF1KSD LDPKPCLTVLGKAKRAVQRGATAVIFDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDPKPCLTVLGKAKRAVQRGATAVIFDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIK
              140       150       160       170       180       190

              100       110       120       130       140       150
pF1KSD LMNIVNKQKVARARIQHRPPRQPTEYFDMGIFLAFFVVVSLVCLILLVKIKLKQRRSQNS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LMNIVNKQKVARARIQHRPPRQPTEYFDMGIFLAFFVVVSLVCLILLVKIKLKQRRSQNS
              200       210       220       230       240       250

              160       170       180       190       200       210
pF1KSD MNRLAVQALEKMETRKFNSKSKGRREGSCGALDTLSSSSTSDCAICLEKYIDGEELRVIP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MNRLAVQALEKMETRKFNSKSKGRREGSCGALDTLSSSSTSDCAICLEKYIDGEELRVIP
              260       270       280       290       300       310

              220       230       240       250       260       270
pF1KSD CTHRFHRKCVDPWLLQHHTCPHCRHNIIEQKGNPSAVCVETSNLSRGRQQRVTLPVHYPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CTHRFHRKCVDPWLLQHHTCPHCRHNIIEQKGNPSAVCVETSNLSRGRQQRVTLPVHYPG
              320       330       340       350       360       370

              280       290       300       310       320       330
pF1KSD RVHRTNAIPAYPTRTSMDSHGNPVTLLTMDRHGEQSLYSPQTPAYIRSYPPLHLDHSLAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RVHRTNAIPAYPTRTSMDSHGNPVTLLTMDRHGEQSLYSPQTPAYIRSYPPLHLDHSLAA
              380       390       400       410       420       430

              340       350       360       370       380       390
pF1KSD HRCGLEHRAYSPAHPFRRPKLSGRSFSKAACFSQYETMYQHYYFQGLSYPEQEGQSPPSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HRCGLEHRAYSPAHPFRRPKLSGRSFSKAACFSQYETMYQHYYFQGLSYPEQEGQSPPSL
              440       450       460       470       480       490

              400       410       420       430       440       450
pF1KSD APRGPARAFPPSGSGSLLFPTVVHVAPPSHLESGSTSSFSCYHGHRSVCSGYLADCPGSD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APRGPARAFPPSGSGSLLFPTVVHVAPPSHLESGSTSSFSCYHGHRSVCSGYLADCPGSD
              500       510       520       530       540       550

              460       470       480       490       500       510
pF1KSD SSSSSSSGQCHCSSSDSVVDCTEVSNQGVYGSCSTFRSSLSSDYDPFIYRSRSPCRASEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSSSSSSGQCHCSSSDSVVDCTEVSNQGVYGSCSTFRSSLSSDYDPFIYRSRSPCRASEA
              560       570       580       590       600       610

              520       530       540       550       560       570
pF1KSD GGSGSSGRGPALCFEGSPPPEELPAVHSHGAGRGEPWPGPASPSGDQVSTCSLEMNYSSN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGSGSSGRGPALCFEGSPPPEELPAVHSHGAGRGEPWPGPASPSGDQVSTCSLEMNYSSN
              620       630       640       650       660       670

              580       590       600       610       620       630
pF1KSD SSLEHRGPNSSTSEVGLEASPGAAPDLRRTWKGGHELPSCACCCEPQPSPAGPSAGAAGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSLEHRGPNSSTSEVGLEASPGAAPDLRRTWKGGHELPSCACCCEPQPSPAGPSAGAAGS
              680       690       700       710       720       730

              640       650       660       670       680       690
pF1KSD STLFLGPHLYEGSGPAGGEPQSGSSQGLYGLHPDHLPRTDGVKYEGLPCCFYEEKQVARG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 STLFLGPHLYEGSGPAGGEPQSGSSQGLYGLHPDHLPRTDGVKYEGLPCCFYEEKQVARG
              740       750       760       770       780       790

              700       710       720       730       740       750
pF1KSD GGGGSGCYTEDYSVSVQYTLTEEPPPGCYPGARDLSQRIPIIPEDVDCDLGLPSDCQGTH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGGGSGCYTEDYSVSVQYTLTEEPPPGCYPGARDLSQRIPIIPEDVDCDLGLPSDCQGTH
              800       810       820       830       840       850

              760       770       780       790       800       810
pF1KSD SLGSWGGTRGPDTPRPHRGLGATREEERALCCQARALLRPGCPPEEAGAVRANFPSALQD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLGSWGGTRGPDTPRPHRGLGATREEERALCCQARALLRPGCPPEEAGAVRANFPSALQD
              860       870       880       890       900       910

              820       830      
pF1KSD TQESSTTATEAAGPRSHSADSSSPGA
       ::::::::::::::::::::::::::
NP_001 TQESSTTATEAAGPRSHSADSSSPGA
              920       930      

>>XP_016880289 (OMIM: 612482,617108) PREDICTED: E3 ubiqu  (869 aa)
 initn: 845 init1: 266 opt: 686  Z-score: 472.4  bits: 98.5 E(85289): 1.4e-19
Smith-Waterman score: 906; 32.2% identity (53.5% similar) in 763 aa overlap (2-720:86-744)

                                            10        20        30 
pF1KSD                              MHPLGLCNNNDEEDLYEYGWVGVVKLEQPEL
                                     ::: ::: .:...: : :....::::.:. 
XP_016 DPTGKLNLTLEGVFAGVAEITPAEGKLMQSHPLYLCNASDDDNL-EPGFISIVKLESPRR
          60        70        80        90        100       110    

              40        50        60        70        80        90 
pF1KSD DPKPCLTVLGKAKRAVQRGATAVIFDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIKL
        :.:::.. .::. : .:::.::.::..:.  : .::.:     :  ::: . : :: ::
XP_016 APRPCLSLASKARMAGERGASAVLFDITEDRAAAEQLQQPL--GLTWPVVLIWGNDAEKL
          120       130       140       150         160       170  

             100        110       120       130       140          
pF1KSD MNIVNKQKVARARIQHR-PPRQPTEYFDMGIFLAFFVVVSLVCLILLVKIKLKQRRSQ-N
       :..: :.. :..::. . ::  :   .:. :...   .. .. :  ...:. . :.:. .
XP_016 MEFVYKNQKAHVRIELKEPPAWPD--YDVWILMTVVGTIFVIILASVLRIRCRPRHSRPD
            180       190         200       210       220       230

     150       160       170       180        190        200       
pF1KSD SMNRLAVQALEKMETRKFNSKSKGRREGSCGAL-DTLSSSSTSD-CAICLEKYIDGEELR
        ... .. :. .. ::..... .  :    :   :. :: :..  ::::::.. .:.:::
XP_016 PLQQRTAWAISQLATRRYQASCRQAR----GEWPDSGSSCSSAPVCAICLEEFSEGQELR
              240       250           260       270       280      

       210       220       230       240       250       260       
pF1KSD VIPCTHRFHRKCVDPWLLQHHTCPHCRHNIIEQKGNPSAVCVETSNLSRGRQQRVTLPVH
       :: : :.:::.:::::: ::.::: :  :: :  .  ...    :    ::  :. :  .
XP_016 VISCLHEFHRNCVDPWLHQHRTCPLCMFNITEGDSFSQSLGPSRSYQEPGR--RLHLIRQ
        290       300       310       320       330         340    

       270       280           290       300       310       320   
pF1KSD YPGRVHRTNAIPAY----PTRTSMDSHGNPVTLLTMDRHGEQSLYSPQTPAYIRSYPPLH
       .::..:    .::     :.:...     :               .:  :.   .. : :
XP_016 HPGHAHYH--LPAAYLLGPSRSAVARPPRP---------------GPFLPSQEPGMGPRH
          350         360       370                      380       

           330       340       350       360       370         380 
pF1KSD LDHSLAAHRCGLEHRAYSPAHPFRRPKLSGRSFSKAACFSQYETMYQHYYFQG--LSYPE
              ::     ::  :  : .. .:.:                :: : ::  ::. .
XP_016 -------HRF---PRAAHPRAPGEQQRLAGA---------------QHPYAQGWGLSHLQ
              390          400                      410       420  

             390       400       410       420       430       440 
pF1KSD QEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHVAPPSHLESGSTSSFSCYHGHRSVCSG
       . .: : .  :    :: ::..:::                 : .     :  .:   ::
XP_016 STSQHPAA-CPVPLRRARPPDSSGS-----------------GES-----YCTER---SG
            430        440                             450         

             450       460       470       480       490       500 
pF1KSD YLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVSNQGVYGSCSTFRSSLSSDYDPFIYRS
       :::: :.:::    ::: :: :::::::.::..: :::.:: ::: ::::::.::..: :
XP_016 YLADGPASDS----SSGPCHGSSSDSVVNCTDISLQGVHGSSSTFCSSLSSDFDPLVYCS
        460           470       480       490       500       510  

               510            520       530       540         550  
pF1KSD RS--PCRASEAGGSGSSGRG-----PALCFEGSPPPEELPAVHSHGAGRGEPWPG--PAS
        .  : :..   .  :  :.     :.   . :   .     : :   : . : :  :. 
XP_016 PKGDPQRVDMQPSVTSRPRSLDSVVPTGETQVSSHVHYHRHRHHHYKKRFQ-WHGRKPGP
            520       530       540       550       560        570 

            560       570       580       590       600       610  
pF1KSD PSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAPDLRRTWKGGHELPSCAC
        .:   :   .     .. . :  .:......     : .:::. : .       :.:  
XP_016 ETGVPQSRPPIP---RTQPQPEPPSPDQQVTR-----SNSAAPSGRLSN------PQCPR
             580          590       600            610             

             620       630                640       650       660  
pF1KSD CC-EPQPSPAGPSAGAAGSSTLF------LG---PHLYEGSGPAGGEPQSGSSQGLYGLH
          :: :.:.  :.   ..:.::      :.   :.  . .::.  ::  ::      .:
XP_016 ALPEPAPGPVDASSICPSTSSLFNLQKSSLSARHPQRKRRGGPS--EPTPGSRPQDATVH
       620       630       640       650       660         670     

               670       680       690                700       710
pF1KSD P--DHLPR-TDGVKYEGLPCCFYEEKQVARGGGG---------GSGCYTEDYSVSVQYTL
       :  . .:. : .: :   :    : . .  :  :          . ::...  : .  : 
XP_016 PACQIFPHYTPSVAYPWSP----EAHPLICGPPGLDKRLLPETPGPCYSNSQPVWLCLTP
         680       690           700       710       720       730 

                 720       730       740       750       760       
pF1KSD TE--EP-PPGCYPGARDLSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTPRPH
        .  :: :::  :                                               
XP_016 RQPLEPHPPGEGPSEWSSDTAEGRPCPYPHCQVLSAQPGEFSEGSGCGRERRLQLNISGQ
             740       750       760       770       780       790 

>>XP_011523257 (OMIM: 612482,617108) PREDICTED: E3 ubiqu  (869 aa)
 initn: 845 init1: 266 opt: 686  Z-score: 472.4  bits: 98.5 E(85289): 1.4e-19
Smith-Waterman score: 906; 32.2% identity (53.5% similar) in 763 aa overlap (2-720:86-744)

                                            10        20        30 
pF1KSD                              MHPLGLCNNNDEEDLYEYGWVGVVKLEQPEL
                                     ::: ::: .:...: : :....::::.:. 
XP_011 DPTGKLNLTLEGVFAGVAEITPAEGKLMQSHPLYLCNASDDDNL-EPGFISIVKLESPRR
          60        70        80        90        100       110    

              40        50        60        70        80        90 
pF1KSD DPKPCLTVLGKAKRAVQRGATAVIFDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIKL
        :.:::.. .::. : .:::.::.::..:.  : .::.:     :  ::: . : :: ::
XP_011 APRPCLSLASKARMAGERGASAVLFDITEDRAAAEQLQQPL--GLTWPVVLIWGNDAEKL
          120       130       140       150         160       170  

             100        110       120       130       140          
pF1KSD MNIVNKQKVARARIQHR-PPRQPTEYFDMGIFLAFFVVVSLVCLILLVKIKLKQRRSQ-N
       :..: :.. :..::. . ::  :   .:. :...   .. .. :  ...:. . :.:. .
XP_011 MEFVYKNQKAHVRIELKEPPAWPD--YDVWILMTVVGTIFVIILASVLRIRCRPRHSRPD
            180       190         200       210       220       230

     150       160       170       180        190        200       
pF1KSD SMNRLAVQALEKMETRKFNSKSKGRREGSCGAL-DTLSSSSTSD-CAICLEKYIDGEELR
        ... .. :. .. ::..... .  :    :   :. :: :..  ::::::.. .:.:::
XP_011 PLQQRTAWAISQLATRRYQASCRQAR----GEWPDSGSSCSSAPVCAICLEEFSEGQELR
              240       250           260       270       280      

       210       220       230       240       250       260       
pF1KSD VIPCTHRFHRKCVDPWLLQHHTCPHCRHNIIEQKGNPSAVCVETSNLSRGRQQRVTLPVH
       :: : :.:::.:::::: ::.::: :  :: :  .  ...    :    ::  :. :  .
XP_011 VISCLHEFHRNCVDPWLHQHRTCPLCMFNITEGDSFSQSLGPSRSYQEPGR--RLHLIRQ
        290       300       310       320       330         340    

       270       280           290       300       310       320   
pF1KSD YPGRVHRTNAIPAY----PTRTSMDSHGNPVTLLTMDRHGEQSLYSPQTPAYIRSYPPLH
       .::..:    .::     :.:...     :               .:  :.   .. : :
XP_011 HPGHAHYH--LPAAYLLGPSRSAVARPPRP---------------GPFLPSQEPGMGPRH
          350         360       370                      380       

           330       340       350       360       370         380 
pF1KSD LDHSLAAHRCGLEHRAYSPAHPFRRPKLSGRSFSKAACFSQYETMYQHYYFQG--LSYPE
              ::     ::  :  : .. .:.:                :: : ::  ::. .
XP_011 -------HRF---PRAAHPRAPGEQQRLAGA---------------QHPYAQGWGLSHLQ
              390          400                      410       420  

             390       400       410       420       430       440 
pF1KSD QEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHVAPPSHLESGSTSSFSCYHGHRSVCSG
       . .: : .  :    :: ::..:::                 : .     :  .:   ::
XP_011 STSQHPAA-CPVPLRRARPPDSSGS-----------------GES-----YCTER---SG
            430        440                             450         

             450       460       470       480       490       500 
pF1KSD YLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVSNQGVYGSCSTFRSSLSSDYDPFIYRS
       :::: :.:::    ::: :: :::::::.::..: :::.:: ::: ::::::.::..: :
XP_011 YLADGPASDS----SSGPCHGSSSDSVVNCTDISLQGVHGSSSTFCSSLSSDFDPLVYCS
        460           470       480       490       500       510  

               510            520       530       540         550  
pF1KSD RS--PCRASEAGGSGSSGRG-----PALCFEGSPPPEELPAVHSHGAGRGEPWPG--PAS
        .  : :..   .  :  :.     :.   . :   .     : :   : . : :  :. 
XP_011 PKGDPQRVDMQPSVTSRPRSLDSVVPTGETQVSSHVHYHRHRHHHYKKRFQ-WHGRKPGP
            520       530       540       550       560        570 

            560       570       580       590       600       610  
pF1KSD PSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAPDLRRTWKGGHELPSCAC
        .:   :   .     .. . :  .:......     : .:::. : .       :.:  
XP_011 ETGVPQSRPPIP---RTQPQPEPPSPDQQVTR-----SNSAAPSGRLSN------PQCPR
             580          590       600            610             

             620       630                640       650       660  
pF1KSD CC-EPQPSPAGPSAGAAGSSTLF------LG---PHLYEGSGPAGGEPQSGSSQGLYGLH
          :: :.:.  :.   ..:.::      :.   :.  . .::.  ::  ::      .:
XP_011 ALPEPAPGPVDASSICPSTSSLFNLQKSSLSARHPQRKRRGGPS--EPTPGSRPQDATVH
       620       630       640       650       660         670     

               670       680       690                700       710
pF1KSD P--DHLPR-TDGVKYEGLPCCFYEEKQVARGGGG---------GSGCYTEDYSVSVQYTL
       :  . .:. : .: :   :    : . .  :  :          . ::...  : .  : 
XP_011 PACQIFPHYTPSVAYPWSP----EAHPLICGPPGLDKRLLPETPGPCYSNSQPVWLCLTP
         680       690           700       710       720       730 

                 720       730       740       750       760       
pF1KSD TE--EP-PPGCYPGARDLSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTPRPH
        .  :: :::  :                                               
XP_011 RQPLEPHPPGEGPSEWSSDTAEGRPCPYPHCQVLSAQPGEFSEGSGCGRERRLQLNISGQ
             740       750       760       770       780       790 

>>NP_060233 (OMIM: 612482,617108) E3 ubiquitin-protein l  (783 aa)
 initn: 845 init1: 266 opt: 662  Z-score: 456.9  bits: 95.4 E(85289): 1e-18
Smith-Waterman score: 919; 31.7% identity (52.9% similar) in 823 aa overlap (2-784:86-782)

                                            10        20        30 
pF1KSD                              MHPLGLCNNNDEEDLYEYGWVGVVKLEQPEL
                                     ::: ::: .:...: : :....::::.:. 
NP_060 DPTGKLNLTLEGVFAGVAEITPAEGKLMQSHPLYLCNASDDDNL-EPGFISIVKLESPRR
          60        70        80        90        100       110    

              40        50        60        70        80        90 
pF1KSD DPKPCLTVLGKAKRAVQRGATAVIFDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIKL
        :.:::.. .::. : .:::.::.::..:.  : .::.:     :  ::: . : :: ::
NP_060 APRPCLSLASKARMAGERGASAVLFDITEDRAAAEQLQQ--PLGLTWPVVLIWGNDAEKL
          120       130       140       150         160       170  

             100        110       120       130       140          
pF1KSD MNIVNKQKVARARIQHR-PPRQPTEYFDMGIFLAFFVVVSLVCLILLVKIKLKQRRSQ-N
       :..: :.. :..::. . ::  :   .:. :...   .. .. :  ...:. . :.:. .
NP_060 MEFVYKNQKAHVRIELKEPPAWPD--YDVWILMTVVGTIFVIILASVLRIRCRPRHSRPD
            180       190         200       210       220       230

     150       160       170       180        190        200       
pF1KSD SMNRLAVQALEKMETRKFNSKSKGRREGSCGAL-DTLSSSSTSD-CAICLEKYIDGEELR
        ... .. :. .. ::..... .  :    :   :. :: :..  ::::::.. .:.:::
NP_060 PLQQRTAWAISQLATRRYQASCRQAR----GEWPDSGSSCSSAPVCAICLEEFSEGQELR
              240       250           260       270       280      

       210       220       230       240       250       260       
pF1KSD VIPCTHRFHRKCVDPWLLQHHTCPHCRHNIIEQKGNPSAVCVETSNLSRGRQQRVTLPVH
       :: : :.:::.:::::: ::.::: :  :: :  .  ...    :    ::  :. :  .
NP_060 VISCLHEFHRNCVDPWLHQHRTCPLCMFNITEGDSFSQSLGPSRSYQEPGR--RLHLIRQ
        290       300       310       320       330         340    

       270       280           290       300       310       320   
pF1KSD YPGRVHRTNAIPAY----PTRTSMDSHGNPVTLLTMDRHGEQSLYSPQTPAYIRSYPPLH
       .::..:    .::     :.:...     :               .:  :.   .. : :
NP_060 HPGHAHYH--LPAAYLLGPSRSAVARPPRP---------------GPFLPSQEPGMGPRH
          350         360       370                      380       

           330       340       350       360       370         380 
pF1KSD LDHSLAAHRCGLEHRAYSPAHPFRRPKLSGRSFSKAACFSQYETMYQHYYFQG--LSYPE
              ::     ::  :  : .. .:.:                :: : ::  ::. .
NP_060 -------HRFP---RAAHPRAPGEQQRLAGA---------------QHPYAQGWGLSHLQ
              390          400                      410       420  

             390       400       410       420       430       440 
pF1KSD QEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHVAPPSHLESGSTSSFSCYHGHRSVCSG
       . .: : .  :    :: ::..:::                 : .     :  .::   :
NP_060 STSQHPAA-CPVPLRRARPPDSSGS-----------------GES-----YCTERS---G
            430        440                             450         

             450       460       470       480       490       500 
pF1KSD YLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVSNQGVYGSCSTFRSSLSSDYDPFIYRS
       :::: :.:::::    : :: :::::::.::..: :::.:: ::: ::::::.::..: :
NP_060 YLADGPASDSSS----GPCHGSSSDSVVNCTDISLQGVHGSSSTFCSSLSSDFDPLVYCS
        460           470       480       490       500       510  

               510            520       530       540         550  
pF1KSD RS--PCRASEAGGSGSSGRG-----PALCFEGSPPPEELPAVHSHGAGRGEPWPG--PAS
        .  : :..   .  :  :.     :.   . :   .     : :   : . : :  :. 
NP_060 PKGDPQRVDMQPSVTSRPRSLDSVVPTGETQVSSHVHYHRHRHHHYKKRFQ-WHGRKPGP
            520       530       540       550       560        570 

            560       570       580       590       600       610  
pF1KSD PSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAPDLRRTWKGGHELPSCAC
        .:   :   .     .. . :  .:......     : .:::. : .       :.:  
NP_060 ETGVPQSRPPIP---RTQPQPEPPSPDQQVTR-----SNSAAPSGRLSN------PQCPR
             580          590       600            610             

             620       630                640       650       660  
pF1KSD CC-EPQPSPAGPSAGAAGSSTLF------LG---PHLYEGSGPAGGEPQSGSSQGLYGLH
          :: :.:.  :.   ..:.::      :.   :.  . .::.  ::  ::      .:
NP_060 ALPEPAPGPVDASSICPSTSSLFNLQKSSLSARHPQRKRRGGPS--EPTPGSRPQDATVH
       620       630       640       650       660         670     

               670       680       690       700       710         
pF1KSD P--DHLPR-TDGVKYEGLPCCFYEEKQVARGGGGGSGCYTEDYSVSVQYTLTEEPPPGCY
       :  . .:. : .: :   :    : . .  :  : .           .  : : : : ::
NP_060 PACQIFPHYTPSVAYPWSP----EAHPLICGPPGLD-----------KRLLPETPGP-CY
         680       690           700                  710          

     720           730       740       750       760        770    
pF1KSD PGARD----LSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTPRPH-RGLGA--
        ...     :. : :. :.        :..  :    .:   ..:   : :: . :.:  
NP_060 SNSQPVWLCLTPRQPLEPHP-------PGE--GPSEWSS-DTAEGRPCPYPHCQVLSAQP
     720       730              740          750       760         

             780       790       800       810       820       830 
pF1KSD -TREEERALCCQARALLRPGCPPEEAGAVRANFPSALQDTQESSTTATEAAGPRSHSADS
        ..:: . :: ::                                               
NP_060 GSEEELEELCEQAV                                              
     770       780                                                 




836 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 05:06:51 2016 done: Thu Nov  3 05:06:53 2016
 Total Scan time: 14.470 Total Display time:  0.230

Function used was FASTA [36.3.4 Apr, 2011]
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