Result of FASTA (omim) for pF1KSDA0967
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KSDA0967, 1578 aa
  1>>>pF1KSDA0967 1578 - 1578 aa - 1578 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 9.7863+/-0.000407; mu= 2.8007+/- 0.025
 mean_var=202.6556+/-41.470, 0's: 0 Z-trim(118.7): 23  B-trim: 1363 in 1/61
 Lambda= 0.090094
 statistics sampled from 31964 (31986) to 31964 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.698), E-opt: 0.2 (0.375), width:  16
 Scan time: 17.220

The best scores are:                                      opt bits E(85289)
NP_055722 (OMIM: 616919) FERM and PDZ domain-conta (1578) 10506 1379.3       0
XP_016869969 (OMIM: 616919) PREDICTED: FERM and PD (1578) 10506 1379.3       0
XP_011516106 (OMIM: 616919) PREDICTED: FERM and PD (1578) 10506 1379.3       0
XP_011516105 (OMIM: 616919) PREDICTED: FERM and PD (1578) 10506 1379.3       0
XP_011516108 (OMIM: 616919) PREDICTED: FERM and PD (1452) 9628 1265.2       0
XP_011516107 (OMIM: 616919) PREDICTED: FERM and PD (1453) 9628 1265.2       0
XP_016869971 (OMIM: 616919) PREDICTED: FERM and PD (1453) 9628 1265.2       0
XP_016869970 (OMIM: 616919) PREDICTED: FERM and PD (1469) 9628 1265.2       0
XP_016885475 (OMIM: 300830,300838,300983) PREDICTE (1319) 1515 210.7 6.9e-53
NP_055543 (OMIM: 300830,300838,300983) FERM and PD (1322) 1515 210.7 6.9e-53
XP_016885474 (OMIM: 300830,300838,300983) PREDICTE (1346) 1515 210.7   7e-53
XP_016885472 (OMIM: 300830,300838,300983) PREDICTE (1759) 1515 210.7 8.9e-53
XP_011543915 (OMIM: 300830,300838,300983) PREDICTE (1762) 1515 210.7 8.9e-53
XP_005274689 (OMIM: 300830,300838,300983) PREDICTE (1786) 1515 210.7   9e-53
XP_016885473 (OMIM: 300830,300838,300983) PREDICTE (1756) 1113 158.4 4.7e-37
XP_005259549 (OMIM: 601869,608792) PREDICTED: PDZ  (1349)  282 50.4 0.00012


>>NP_055722 (OMIM: 616919) FERM and PDZ domain-containin  (1578 aa)
 initn: 10506 init1: 10506 opt: 10506  Z-score: 7385.1  bits: 1379.3 E(85289):    0
Smith-Waterman score: 10506; 99.9% identity (99.9% similar) in 1578 aa overlap (1-1578:1-1578)

               10        20        30        40        50        60
pF1KSD MEELETSLFQTRKAHRIEQMVARWLRRSRDSSARAKVAAADGPARNPTQTLIPVRHTVKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MEELETSLFQTRKAHRIEQMVARWLRRSRDSSARAKVAAADGPARNPTQTLIPVRHTVKI
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD DKDTLLQDYGFHISESLPLTVVAVTAGGSAHGKLFPGDQILQMNNEPAEDLSWERAVDIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 DKDTLLQDYGFHISESLPLTVVAVTAGGSAHGKLFPGDQILQMNNEPAEDLSWERAVDIL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD REAEDSLSITVVRCTSGVPKSSFLTEEKRARLKTNPVKVHFAEEVLISGHSQGNSLLCMP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 REAEDSLSITVVRCTSGVPKSSFLTEEKRARLKTNPVKVHFAEEVLISGHSQGNSLLCMP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD NVLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALALEEQYSISRLHLLHE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 NVLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALALEEQYSISRLHLLHE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD EELIQQVVEREESHDYRCLFRVCFVPKDPLDLLKEDPVAFEYLYLQSCSDVLQERFAVEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 EELIQQVVEREESHDYRCLFRVCFVPKDPLDLLKEDPVAFEYLYLQSCSDVLQERFAVEM
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD KCSSALRLAALHIQERIYACAQPQKISLKYIEKDWGIENFISPTLLRNMKGKDIKKAISF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KCSSALRLAALHIQERIYACAQPQKISLKYIEKDWGIENFISPTLLRNMKGKDIKKAISF
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD HMKRNQNLLEPRQKQLISAAQLRLNYLQILGELKTYGGRIFNATLMLQDRESYIALLVGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 HMKRNQNLLEPRQKQLISAAQLRLNYLQILGELKTYGGRIFNATLMLQDRESYIALLVGA
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD KYGISQVINSKLNIMSTLAEFANISRVELTEESEKVSVVKVYLQDVKVLTLLLESNSAKD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KYGISQVINSKLNIMSTLAEFANISRVELTEESEKVSVVKVYLQDVKVLTLLLESNSAKD
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KSD LACLIAGYYRLLVDPVTSIFLWPGNKQQAHRVSAEEGYESRACSDSEESSEVDCVLEPLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LACLIAGYYRLLVDPVTSIFLWPGNKQQAHRVSAEEGYESRACSDSEESSEVDCVLEPLS
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KSD DRRLVKLAPCRSLIKEEQPPGNSPTPEVARRGPSTCGASSTTDSAESEASDSANTESRGY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 DRRLVKLAPCRSLIKEEQPPGNSPTPEVARRGPSTCGASSTTDSAESEASDSANTESRGY
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KSD RTSGSSESMDALEEDDLDTCSSSRSTFFHFGSPGLAESIDSDSQEERSGIETSGFLCLLD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 RTSGSSESMDALEEDDLDTCSSSRSTFFHFGSPGLAESIDSDSQEERSGIETSGFLCLLD
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KSD LAQRANPQCQKTEFSESAALETFGWAPELSTVRLDPRLYEGSHADYYSLCSSVSPASYLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LAQRANPQCQKTEFSESAALETFGWAPELSTVRLDPRLYEGSHADYYSLCSSVSPASYLS
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KSD DSSESTASRQGGAPPAWGQQGWTEAQPSSMLEPLALHPPLAFEDGSSDEEYYDAADKLTP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 DSSESTASRQGGAPPAWGQQGWTEAQPSSMLEPLALHPPLAFEDGSSDEEYYDAADKLTP
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KSD PGPPSGPRDVSTAEPSATSLQNKASTSSPENSLPCGPDGRQPSRRGGVKKYAKTLRKRRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 PGPPSGPRDVSTAEPSATSLQNKASTSSPENSLPCGPDGRQPSRRGGVKKYAKTLRKRRS
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KSD FLQTDYTSQVSFPLVPSASLESVDDVCYYDREPYLALGAPSPTVSSLQDMQGEPGLLETK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 FLQTDYTSQVSFPLVPSASLESVDDVCYYDREPYLALGAPSPTVSSLQDMQGEPGLLETK
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KSD ALGLLAPLRETKSTNPASRVMEMEPETMETKSVIDSRVSSISAIRFRIDPNNKENSGVVP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 ALGLLAPLRETKSTNPASRVMEMEPETMETKSVIDSRVSSISAIRFRIDPNNKENSGVVP
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KSD AASSSASTPHCSNPGSSGPDTAQARPSQILPLSQDLDGIAPKEPTIEHGDSSFSLSSGDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 AASSSASTPHCSNPGSSGPDTAQARPSQILPLSQDLDGIAPKEPTIEHGDSSFSLSSGDP
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KSD NPDRACLASNPGLNNVSQGDTLELQLEPHVQLEMGLESFCTNHIQETAPKYTEPLLSPRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 NPDRACLASNPGLNNVSQGDTLELQLEPHVQLEMGLESFCTNHIQETAPKYTEPLLSPRD
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KSD EPRSDECGINPGEKIASIPTKEEPQGQLSLERDREVTNKNGTNVFQEESRKDSGDSPGDV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 EPRSDECGINPGEKIASIPTKEEPQGQLSLERDREVTNKNGTNVFQEESRKDSGDSPGDV
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KSD SNNVSQTLDISSPAGKIVTSLSLDAPVTGTEQIPPHPPRDPQGQSREPPGQGCQAQEQKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SNNVSQTLDISSPAGKIVTSLSLDAPVTGTEQIPPHPPRDPQGQSREPPGQGCQAQEQKL
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KSD FVELDLDPDFFLGKQTVSPAVPPEGIKAEAPNHVTGQDIAPRDSPEWVCFNPEPSLPEPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 FVELDLDPDFFLGKQTVSPAVPPEGIKAEAPNHVTGQDIAPRDSPEWVCFNPEPSLPEPL
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KSD PCPQEDPHLETSNHCLLLEGKSDSSSICLSAEKSFLCFAPESHPEVSASLRVATSLGFAG
       ::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::
NP_055 PCPQEDPHLETSNHCLLSEGKSDSSSICLSAEKSFLCFAPESHPEVSASLRVATSLGFAG
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KSD MNEMVAPRIGMDQCSCQFSYATCFRGPQPETEEEDRDLEAHPMAPLTSPPSAGSPVVLPW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MNEMVAPRIGMDQCSCQFSYATCFRGPQPETEEEDRDLEAHPMAPLTSPPSAGSPVVLPW
             1330      1340      1350      1360      1370      1380

             1390      1400      1410      1420      1430      1440
pF1KSD RPARAHSCTTAPLSRKSHIWPEYCSRALRQLKATPASTPEGFIQLMESLLELQDILETSW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 RPARAHSCTTAPLSRKSHIWPEYCSRALRQLKATPASTPEGFIQLMESLLELQDILETSW
             1390      1400      1410      1420      1430      1440

             1450      1460      1470      1480      1490      1500
pF1KSD GVGNKHPPEKCTWHFTESRSRLCMGSQKLLSSCRHVIRMDQSPEEMQGAVRDTFQHLVQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GVGNKHPPEKCTWHFTESRSRLCMGSQKLLSSCRHVIRMDQSPEEMQGAVRDTFQHLVQL
             1450      1460      1470      1480      1490      1500

             1510      1520      1530      1540      1550      1560
pF1KSD AGLCFQFTDCSRCSARHREAAGNLRDVVYTYHQFIEAAKSTCERGYHDLSVKLLARQCTA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 AGLCFQFTDCSRCSARHREAAGNLRDVVYTYHQFIEAAKSTCERGYHDLSVKLLARQCTA
             1510      1520      1530      1540      1550      1560

             1570        
pF1KSD LTAAVFCLTQKFRASTAL
       ::::::::::::::::::
NP_055 LTAAVFCLTQKFRASTAL
             1570        

>>XP_016869969 (OMIM: 616919) PREDICTED: FERM and PDZ do  (1578 aa)
 initn: 10506 init1: 10506 opt: 10506  Z-score: 7385.1  bits: 1379.3 E(85289):    0
Smith-Waterman score: 10506; 99.9% identity (99.9% similar) in 1578 aa overlap (1-1578:1-1578)

               10        20        30        40        50        60
pF1KSD MEELETSLFQTRKAHRIEQMVARWLRRSRDSSARAKVAAADGPARNPTQTLIPVRHTVKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEELETSLFQTRKAHRIEQMVARWLRRSRDSSARAKVAAADGPARNPTQTLIPVRHTVKI
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD DKDTLLQDYGFHISESLPLTVVAVTAGGSAHGKLFPGDQILQMNNEPAEDLSWERAVDIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DKDTLLQDYGFHISESLPLTVVAVTAGGSAHGKLFPGDQILQMNNEPAEDLSWERAVDIL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD REAEDSLSITVVRCTSGVPKSSFLTEEKRARLKTNPVKVHFAEEVLISGHSQGNSLLCMP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 REAEDSLSITVVRCTSGVPKSSFLTEEKRARLKTNPVKVHFAEEVLISGHSQGNSLLCMP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD NVLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALALEEQYSISRLHLLHE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NVLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALALEEQYSISRLHLLHE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD EELIQQVVEREESHDYRCLFRVCFVPKDPLDLLKEDPVAFEYLYLQSCSDVLQERFAVEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EELIQQVVEREESHDYRCLFRVCFVPKDPLDLLKEDPVAFEYLYLQSCSDVLQERFAVEM
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD KCSSALRLAALHIQERIYACAQPQKISLKYIEKDWGIENFISPTLLRNMKGKDIKKAISF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KCSSALRLAALHIQERIYACAQPQKISLKYIEKDWGIENFISPTLLRNMKGKDIKKAISF
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD HMKRNQNLLEPRQKQLISAAQLRLNYLQILGELKTYGGRIFNATLMLQDRESYIALLVGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HMKRNQNLLEPRQKQLISAAQLRLNYLQILGELKTYGGRIFNATLMLQDRESYIALLVGA
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD KYGISQVINSKLNIMSTLAEFANISRVELTEESEKVSVVKVYLQDVKVLTLLLESNSAKD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KYGISQVINSKLNIMSTLAEFANISRVELTEESEKVSVVKVYLQDVKVLTLLLESNSAKD
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KSD LACLIAGYYRLLVDPVTSIFLWPGNKQQAHRVSAEEGYESRACSDSEESSEVDCVLEPLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LACLIAGYYRLLVDPVTSIFLWPGNKQQAHRVSAEEGYESRACSDSEESSEVDCVLEPLS
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KSD DRRLVKLAPCRSLIKEEQPPGNSPTPEVARRGPSTCGASSTTDSAESEASDSANTESRGY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DRRLVKLAPCRSLIKEEQPPGNSPTPEVARRGPSTCGASSTTDSAESEASDSANTESRGY
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KSD RTSGSSESMDALEEDDLDTCSSSRSTFFHFGSPGLAESIDSDSQEERSGIETSGFLCLLD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RTSGSSESMDALEEDDLDTCSSSRSTFFHFGSPGLAESIDSDSQEERSGIETSGFLCLLD
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KSD LAQRANPQCQKTEFSESAALETFGWAPELSTVRLDPRLYEGSHADYYSLCSSVSPASYLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAQRANPQCQKTEFSESAALETFGWAPELSTVRLDPRLYEGSHADYYSLCSSVSPASYLS
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KSD DSSESTASRQGGAPPAWGQQGWTEAQPSSMLEPLALHPPLAFEDGSSDEEYYDAADKLTP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSSESTASRQGGAPPAWGQQGWTEAQPSSMLEPLALHPPLAFEDGSSDEEYYDAADKLTP
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KSD PGPPSGPRDVSTAEPSATSLQNKASTSSPENSLPCGPDGRQPSRRGGVKKYAKTLRKRRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGPPSGPRDVSTAEPSATSLQNKASTSSPENSLPCGPDGRQPSRRGGVKKYAKTLRKRRS
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KSD FLQTDYTSQVSFPLVPSASLESVDDVCYYDREPYLALGAPSPTVSSLQDMQGEPGLLETK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FLQTDYTSQVSFPLVPSASLESVDDVCYYDREPYLALGAPSPTVSSLQDMQGEPGLLETK
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KSD ALGLLAPLRETKSTNPASRVMEMEPETMETKSVIDSRVSSISAIRFRIDPNNKENSGVVP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALGLLAPLRETKSTNPASRVMEMEPETMETKSVIDSRVSSISAIRFRIDPNNKENSGVVP
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KSD AASSSASTPHCSNPGSSGPDTAQARPSQILPLSQDLDGIAPKEPTIEHGDSSFSLSSGDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AASSSASTPHCSNPGSSGPDTAQARPSQILPLSQDLDGIAPKEPTIEHGDSSFSLSSGDP
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KSD NPDRACLASNPGLNNVSQGDTLELQLEPHVQLEMGLESFCTNHIQETAPKYTEPLLSPRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NPDRACLASNPGLNNVSQGDTLELQLEPHVQLEMGLESFCTNHIQETAPKYTEPLLSPRD
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KSD EPRSDECGINPGEKIASIPTKEEPQGQLSLERDREVTNKNGTNVFQEESRKDSGDSPGDV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EPRSDECGINPGEKIASIPTKEEPQGQLSLERDREVTNKNGTNVFQEESRKDSGDSPGDV
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KSD SNNVSQTLDISSPAGKIVTSLSLDAPVTGTEQIPPHPPRDPQGQSREPPGQGCQAQEQKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNNVSQTLDISSPAGKIVTSLSLDAPVTGTEQIPPHPPRDPQGQSREPPGQGCQAQEQKL
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KSD FVELDLDPDFFLGKQTVSPAVPPEGIKAEAPNHVTGQDIAPRDSPEWVCFNPEPSLPEPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FVELDLDPDFFLGKQTVSPAVPPEGIKAEAPNHVTGQDIAPRDSPEWVCFNPEPSLPEPL
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KSD PCPQEDPHLETSNHCLLLEGKSDSSSICLSAEKSFLCFAPESHPEVSASLRVATSLGFAG
       ::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::
XP_016 PCPQEDPHLETSNHCLLSEGKSDSSSICLSAEKSFLCFAPESHPEVSASLRVATSLGFAG
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KSD MNEMVAPRIGMDQCSCQFSYATCFRGPQPETEEEDRDLEAHPMAPLTSPPSAGSPVVLPW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNEMVAPRIGMDQCSCQFSYATCFRGPQPETEEEDRDLEAHPMAPLTSPPSAGSPVVLPW
             1330      1340      1350      1360      1370      1380

             1390      1400      1410      1420      1430      1440
pF1KSD RPARAHSCTTAPLSRKSHIWPEYCSRALRQLKATPASTPEGFIQLMESLLELQDILETSW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPARAHSCTTAPLSRKSHIWPEYCSRALRQLKATPASTPEGFIQLMESLLELQDILETSW
             1390      1400      1410      1420      1430      1440

             1450      1460      1470      1480      1490      1500
pF1KSD GVGNKHPPEKCTWHFTESRSRLCMGSQKLLSSCRHVIRMDQSPEEMQGAVRDTFQHLVQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GVGNKHPPEKCTWHFTESRSRLCMGSQKLLSSCRHVIRMDQSPEEMQGAVRDTFQHLVQL
             1450      1460      1470      1480      1490      1500

             1510      1520      1530      1540      1550      1560
pF1KSD AGLCFQFTDCSRCSARHREAAGNLRDVVYTYHQFIEAAKSTCERGYHDLSVKLLARQCTA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGLCFQFTDCSRCSARHREAAGNLRDVVYTYHQFIEAAKSTCERGYHDLSVKLLARQCTA
             1510      1520      1530      1540      1550      1560

             1570        
pF1KSD LTAAVFCLTQKFRASTAL
       ::::::::::::::::::
XP_016 LTAAVFCLTQKFRASTAL
             1570        

>>XP_011516106 (OMIM: 616919) PREDICTED: FERM and PDZ do  (1578 aa)
 initn: 10506 init1: 10506 opt: 10506  Z-score: 7385.1  bits: 1379.3 E(85289):    0
Smith-Waterman score: 10506; 99.9% identity (99.9% similar) in 1578 aa overlap (1-1578:1-1578)

               10        20        30        40        50        60
pF1KSD MEELETSLFQTRKAHRIEQMVARWLRRSRDSSARAKVAAADGPARNPTQTLIPVRHTVKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEELETSLFQTRKAHRIEQMVARWLRRSRDSSARAKVAAADGPARNPTQTLIPVRHTVKI
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD DKDTLLQDYGFHISESLPLTVVAVTAGGSAHGKLFPGDQILQMNNEPAEDLSWERAVDIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DKDTLLQDYGFHISESLPLTVVAVTAGGSAHGKLFPGDQILQMNNEPAEDLSWERAVDIL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD REAEDSLSITVVRCTSGVPKSSFLTEEKRARLKTNPVKVHFAEEVLISGHSQGNSLLCMP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 REAEDSLSITVVRCTSGVPKSSFLTEEKRARLKTNPVKVHFAEEVLISGHSQGNSLLCMP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD NVLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALALEEQYSISRLHLLHE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NVLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALALEEQYSISRLHLLHE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD EELIQQVVEREESHDYRCLFRVCFVPKDPLDLLKEDPVAFEYLYLQSCSDVLQERFAVEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EELIQQVVEREESHDYRCLFRVCFVPKDPLDLLKEDPVAFEYLYLQSCSDVLQERFAVEM
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD KCSSALRLAALHIQERIYACAQPQKISLKYIEKDWGIENFISPTLLRNMKGKDIKKAISF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KCSSALRLAALHIQERIYACAQPQKISLKYIEKDWGIENFISPTLLRNMKGKDIKKAISF
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD HMKRNQNLLEPRQKQLISAAQLRLNYLQILGELKTYGGRIFNATLMLQDRESYIALLVGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HMKRNQNLLEPRQKQLISAAQLRLNYLQILGELKTYGGRIFNATLMLQDRESYIALLVGA
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD KYGISQVINSKLNIMSTLAEFANISRVELTEESEKVSVVKVYLQDVKVLTLLLESNSAKD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KYGISQVINSKLNIMSTLAEFANISRVELTEESEKVSVVKVYLQDVKVLTLLLESNSAKD
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KSD LACLIAGYYRLLVDPVTSIFLWPGNKQQAHRVSAEEGYESRACSDSEESSEVDCVLEPLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LACLIAGYYRLLVDPVTSIFLWPGNKQQAHRVSAEEGYESRACSDSEESSEVDCVLEPLS
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KSD DRRLVKLAPCRSLIKEEQPPGNSPTPEVARRGPSTCGASSTTDSAESEASDSANTESRGY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DRRLVKLAPCRSLIKEEQPPGNSPTPEVARRGPSTCGASSTTDSAESEASDSANTESRGY
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KSD RTSGSSESMDALEEDDLDTCSSSRSTFFHFGSPGLAESIDSDSQEERSGIETSGFLCLLD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTSGSSESMDALEEDDLDTCSSSRSTFFHFGSPGLAESIDSDSQEERSGIETSGFLCLLD
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KSD LAQRANPQCQKTEFSESAALETFGWAPELSTVRLDPRLYEGSHADYYSLCSSVSPASYLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAQRANPQCQKTEFSESAALETFGWAPELSTVRLDPRLYEGSHADYYSLCSSVSPASYLS
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KSD DSSESTASRQGGAPPAWGQQGWTEAQPSSMLEPLALHPPLAFEDGSSDEEYYDAADKLTP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DSSESTASRQGGAPPAWGQQGWTEAQPSSMLEPLALHPPLAFEDGSSDEEYYDAADKLTP
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KSD PGPPSGPRDVSTAEPSATSLQNKASTSSPENSLPCGPDGRQPSRRGGVKKYAKTLRKRRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGPPSGPRDVSTAEPSATSLQNKASTSSPENSLPCGPDGRQPSRRGGVKKYAKTLRKRRS
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KSD FLQTDYTSQVSFPLVPSASLESVDDVCYYDREPYLALGAPSPTVSSLQDMQGEPGLLETK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FLQTDYTSQVSFPLVPSASLESVDDVCYYDREPYLALGAPSPTVSSLQDMQGEPGLLETK
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KSD ALGLLAPLRETKSTNPASRVMEMEPETMETKSVIDSRVSSISAIRFRIDPNNKENSGVVP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALGLLAPLRETKSTNPASRVMEMEPETMETKSVIDSRVSSISAIRFRIDPNNKENSGVVP
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KSD AASSSASTPHCSNPGSSGPDTAQARPSQILPLSQDLDGIAPKEPTIEHGDSSFSLSSGDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AASSSASTPHCSNPGSSGPDTAQARPSQILPLSQDLDGIAPKEPTIEHGDSSFSLSSGDP
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KSD NPDRACLASNPGLNNVSQGDTLELQLEPHVQLEMGLESFCTNHIQETAPKYTEPLLSPRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NPDRACLASNPGLNNVSQGDTLELQLEPHVQLEMGLESFCTNHIQETAPKYTEPLLSPRD
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KSD EPRSDECGINPGEKIASIPTKEEPQGQLSLERDREVTNKNGTNVFQEESRKDSGDSPGDV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EPRSDECGINPGEKIASIPTKEEPQGQLSLERDREVTNKNGTNVFQEESRKDSGDSPGDV
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KSD SNNVSQTLDISSPAGKIVTSLSLDAPVTGTEQIPPHPPRDPQGQSREPPGQGCQAQEQKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SNNVSQTLDISSPAGKIVTSLSLDAPVTGTEQIPPHPPRDPQGQSREPPGQGCQAQEQKL
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KSD FVELDLDPDFFLGKQTVSPAVPPEGIKAEAPNHVTGQDIAPRDSPEWVCFNPEPSLPEPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FVELDLDPDFFLGKQTVSPAVPPEGIKAEAPNHVTGQDIAPRDSPEWVCFNPEPSLPEPL
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KSD PCPQEDPHLETSNHCLLLEGKSDSSSICLSAEKSFLCFAPESHPEVSASLRVATSLGFAG
       ::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::
XP_011 PCPQEDPHLETSNHCLLSEGKSDSSSICLSAEKSFLCFAPESHPEVSASLRVATSLGFAG
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KSD MNEMVAPRIGMDQCSCQFSYATCFRGPQPETEEEDRDLEAHPMAPLTSPPSAGSPVVLPW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MNEMVAPRIGMDQCSCQFSYATCFRGPQPETEEEDRDLEAHPMAPLTSPPSAGSPVVLPW
             1330      1340      1350      1360      1370      1380

             1390      1400      1410      1420      1430      1440
pF1KSD RPARAHSCTTAPLSRKSHIWPEYCSRALRQLKATPASTPEGFIQLMESLLELQDILETSW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RPARAHSCTTAPLSRKSHIWPEYCSRALRQLKATPASTPEGFIQLMESLLELQDILETSW
             1390      1400      1410      1420      1430      1440

             1450      1460      1470      1480      1490      1500
pF1KSD GVGNKHPPEKCTWHFTESRSRLCMGSQKLLSSCRHVIRMDQSPEEMQGAVRDTFQHLVQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GVGNKHPPEKCTWHFTESRSRLCMGSQKLLSSCRHVIRMDQSPEEMQGAVRDTFQHLVQL
             1450      1460      1470      1480      1490      1500

             1510      1520      1530      1540      1550      1560
pF1KSD AGLCFQFTDCSRCSARHREAAGNLRDVVYTYHQFIEAAKSTCERGYHDLSVKLLARQCTA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGLCFQFTDCSRCSARHREAAGNLRDVVYTYHQFIEAAKSTCERGYHDLSVKLLARQCTA
             1510      1520      1530      1540      1550      1560

             1570        
pF1KSD LTAAVFCLTQKFRASTAL
       ::::::::::::::::::
XP_011 LTAAVFCLTQKFRASTAL
             1570        

>>XP_011516105 (OMIM: 616919) PREDICTED: FERM and PDZ do  (1578 aa)
 initn: 10506 init1: 10506 opt: 10506  Z-score: 7385.1  bits: 1379.3 E(85289):    0
Smith-Waterman score: 10506; 99.9% identity (99.9% similar) in 1578 aa overlap (1-1578:1-1578)

               10        20        30        40        50        60
pF1KSD MEELETSLFQTRKAHRIEQMVARWLRRSRDSSARAKVAAADGPARNPTQTLIPVRHTVKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEELETSLFQTRKAHRIEQMVARWLRRSRDSSARAKVAAADGPARNPTQTLIPVRHTVKI
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD DKDTLLQDYGFHISESLPLTVVAVTAGGSAHGKLFPGDQILQMNNEPAEDLSWERAVDIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DKDTLLQDYGFHISESLPLTVVAVTAGGSAHGKLFPGDQILQMNNEPAEDLSWERAVDIL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD REAEDSLSITVVRCTSGVPKSSFLTEEKRARLKTNPVKVHFAEEVLISGHSQGNSLLCMP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 REAEDSLSITVVRCTSGVPKSSFLTEEKRARLKTNPVKVHFAEEVLISGHSQGNSLLCMP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD NVLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALALEEQYSISRLHLLHE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NVLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALALEEQYSISRLHLLHE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD EELIQQVVEREESHDYRCLFRVCFVPKDPLDLLKEDPVAFEYLYLQSCSDVLQERFAVEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EELIQQVVEREESHDYRCLFRVCFVPKDPLDLLKEDPVAFEYLYLQSCSDVLQERFAVEM
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD KCSSALRLAALHIQERIYACAQPQKISLKYIEKDWGIENFISPTLLRNMKGKDIKKAISF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KCSSALRLAALHIQERIYACAQPQKISLKYIEKDWGIENFISPTLLRNMKGKDIKKAISF
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD HMKRNQNLLEPRQKQLISAAQLRLNYLQILGELKTYGGRIFNATLMLQDRESYIALLVGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HMKRNQNLLEPRQKQLISAAQLRLNYLQILGELKTYGGRIFNATLMLQDRESYIALLVGA
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD KYGISQVINSKLNIMSTLAEFANISRVELTEESEKVSVVKVYLQDVKVLTLLLESNSAKD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KYGISQVINSKLNIMSTLAEFANISRVELTEESEKVSVVKVYLQDVKVLTLLLESNSAKD
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KSD LACLIAGYYRLLVDPVTSIFLWPGNKQQAHRVSAEEGYESRACSDSEESSEVDCVLEPLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LACLIAGYYRLLVDPVTSIFLWPGNKQQAHRVSAEEGYESRACSDSEESSEVDCVLEPLS
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KSD DRRLVKLAPCRSLIKEEQPPGNSPTPEVARRGPSTCGASSTTDSAESEASDSANTESRGY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DRRLVKLAPCRSLIKEEQPPGNSPTPEVARRGPSTCGASSTTDSAESEASDSANTESRGY
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KSD RTSGSSESMDALEEDDLDTCSSSRSTFFHFGSPGLAESIDSDSQEERSGIETSGFLCLLD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTSGSSESMDALEEDDLDTCSSSRSTFFHFGSPGLAESIDSDSQEERSGIETSGFLCLLD
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KSD LAQRANPQCQKTEFSESAALETFGWAPELSTVRLDPRLYEGSHADYYSLCSSVSPASYLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAQRANPQCQKTEFSESAALETFGWAPELSTVRLDPRLYEGSHADYYSLCSSVSPASYLS
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KSD DSSESTASRQGGAPPAWGQQGWTEAQPSSMLEPLALHPPLAFEDGSSDEEYYDAADKLTP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DSSESTASRQGGAPPAWGQQGWTEAQPSSMLEPLALHPPLAFEDGSSDEEYYDAADKLTP
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KSD PGPPSGPRDVSTAEPSATSLQNKASTSSPENSLPCGPDGRQPSRRGGVKKYAKTLRKRRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGPPSGPRDVSTAEPSATSLQNKASTSSPENSLPCGPDGRQPSRRGGVKKYAKTLRKRRS
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KSD FLQTDYTSQVSFPLVPSASLESVDDVCYYDREPYLALGAPSPTVSSLQDMQGEPGLLETK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FLQTDYTSQVSFPLVPSASLESVDDVCYYDREPYLALGAPSPTVSSLQDMQGEPGLLETK
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KSD ALGLLAPLRETKSTNPASRVMEMEPETMETKSVIDSRVSSISAIRFRIDPNNKENSGVVP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALGLLAPLRETKSTNPASRVMEMEPETMETKSVIDSRVSSISAIRFRIDPNNKENSGVVP
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KSD AASSSASTPHCSNPGSSGPDTAQARPSQILPLSQDLDGIAPKEPTIEHGDSSFSLSSGDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AASSSASTPHCSNPGSSGPDTAQARPSQILPLSQDLDGIAPKEPTIEHGDSSFSLSSGDP
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KSD NPDRACLASNPGLNNVSQGDTLELQLEPHVQLEMGLESFCTNHIQETAPKYTEPLLSPRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NPDRACLASNPGLNNVSQGDTLELQLEPHVQLEMGLESFCTNHIQETAPKYTEPLLSPRD
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KSD EPRSDECGINPGEKIASIPTKEEPQGQLSLERDREVTNKNGTNVFQEESRKDSGDSPGDV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EPRSDECGINPGEKIASIPTKEEPQGQLSLERDREVTNKNGTNVFQEESRKDSGDSPGDV
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KSD SNNVSQTLDISSPAGKIVTSLSLDAPVTGTEQIPPHPPRDPQGQSREPPGQGCQAQEQKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SNNVSQTLDISSPAGKIVTSLSLDAPVTGTEQIPPHPPRDPQGQSREPPGQGCQAQEQKL
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KSD FVELDLDPDFFLGKQTVSPAVPPEGIKAEAPNHVTGQDIAPRDSPEWVCFNPEPSLPEPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FVELDLDPDFFLGKQTVSPAVPPEGIKAEAPNHVTGQDIAPRDSPEWVCFNPEPSLPEPL
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KSD PCPQEDPHLETSNHCLLLEGKSDSSSICLSAEKSFLCFAPESHPEVSASLRVATSLGFAG
       ::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::
XP_011 PCPQEDPHLETSNHCLLSEGKSDSSSICLSAEKSFLCFAPESHPEVSASLRVATSLGFAG
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KSD MNEMVAPRIGMDQCSCQFSYATCFRGPQPETEEEDRDLEAHPMAPLTSPPSAGSPVVLPW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MNEMVAPRIGMDQCSCQFSYATCFRGPQPETEEEDRDLEAHPMAPLTSPPSAGSPVVLPW
             1330      1340      1350      1360      1370      1380

             1390      1400      1410      1420      1430      1440
pF1KSD RPARAHSCTTAPLSRKSHIWPEYCSRALRQLKATPASTPEGFIQLMESLLELQDILETSW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RPARAHSCTTAPLSRKSHIWPEYCSRALRQLKATPASTPEGFIQLMESLLELQDILETSW
             1390      1400      1410      1420      1430      1440

             1450      1460      1470      1480      1490      1500
pF1KSD GVGNKHPPEKCTWHFTESRSRLCMGSQKLLSSCRHVIRMDQSPEEMQGAVRDTFQHLVQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GVGNKHPPEKCTWHFTESRSRLCMGSQKLLSSCRHVIRMDQSPEEMQGAVRDTFQHLVQL
             1450      1460      1470      1480      1490      1500

             1510      1520      1530      1540      1550      1560
pF1KSD AGLCFQFTDCSRCSARHREAAGNLRDVVYTYHQFIEAAKSTCERGYHDLSVKLLARQCTA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGLCFQFTDCSRCSARHREAAGNLRDVVYTYHQFIEAAKSTCERGYHDLSVKLLARQCTA
             1510      1520      1530      1540      1550      1560

             1570        
pF1KSD LTAAVFCLTQKFRASTAL
       ::::::::::::::::::
XP_011 LTAAVFCLTQKFRASTAL
             1570        

>>XP_011516108 (OMIM: 616919) PREDICTED: FERM and PDZ do  (1452 aa)
 initn: 9628 init1: 9628 opt: 9628  Z-score: 6768.9  bits: 1265.2 E(85289):    0
Smith-Waterman score: 9628; 99.9% identity (99.9% similar) in 1442 aa overlap (137-1578:11-1452)

        110       120       130       140       150       160      
pF1KSD PAEDLSWERAVDILREAEDSLSITVVRCTSGVPKSSFLTEEKRARLKTNPVKVHFAEEVL
                                     ::::::::::::::::::::::::::::::
XP_011                     MNLIGSDLFLGVPKSSFLTEEKRARLKTNPVKVHFAEEVL
                                   10        20        30        40

        170       180       190       200       210       220      
pF1KSD ISGHSQGNSLLCMPNVLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ISGHSQGNSLLCMPNVLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALAL
               50        60        70        80        90       100

        230       240       250       260       270       280      
pF1KSD EEQYSISRLHLLHEEELIQQVVEREESHDYRCLFRVCFVPKDPLDLLKEDPVAFEYLYLQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEQYSISRLHLLHEEELIQQVVEREESHDYRCLFRVCFVPKDPLDLLKEDPVAFEYLYLQ
              110       120       130       140       150       160

        290       300       310       320       330       340      
pF1KSD SCSDVLQERFAVEMKCSSALRLAALHIQERIYACAQPQKISLKYIEKDWGIENFISPTLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SCSDVLQERFAVEMKCSSALRLAALHIQERIYACAQPQKISLKYIEKDWGIENFISPTLL
              170       180       190       200       210       220

        350       360       370       380       390       400      
pF1KSD RNMKGKDIKKAISFHMKRNQNLLEPRQKQLISAAQLRLNYLQILGELKTYGGRIFNATLM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RNMKGKDIKKAISFHMKRNQNLLEPRQKQLISAAQLRLNYLQILGELKTYGGRIFNATLM
              230       240       250       260       270       280

        410       420       430       440       450       460      
pF1KSD LQDRESYIALLVGAKYGISQVINSKLNIMSTLAEFANISRVELTEESEKVSVVKVYLQDV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQDRESYIALLVGAKYGISQVINSKLNIMSTLAEFANISRVELTEESEKVSVVKVYLQDV
              290       300       310       320       330       340

        470       480       490       500       510       520      
pF1KSD KVLTLLLESNSAKDLACLIAGYYRLLVDPVTSIFLWPGNKQQAHRVSAEEGYESRACSDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVLTLLLESNSAKDLACLIAGYYRLLVDPVTSIFLWPGNKQQAHRVSAEEGYESRACSDS
              350       360       370       380       390       400

        530       540       550       560       570       580      
pF1KSD EESSEVDCVLEPLSDRRLVKLAPCRSLIKEEQPPGNSPTPEVARRGPSTCGASSTTDSAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EESSEVDCVLEPLSDRRLVKLAPCRSLIKEEQPPGNSPTPEVARRGPSTCGASSTTDSAE
              410       420       430       440       450       460

        590       600       610       620       630       640      
pF1KSD SEASDSANTESRGYRTSGSSESMDALEEDDLDTCSSSRSTFFHFGSPGLAESIDSDSQEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SEASDSANTESRGYRTSGSSESMDALEEDDLDTCSSSRSTFFHFGSPGLAESIDSDSQEE
              470       480       490       500       510       520

        650       660       670       680       690       700      
pF1KSD RSGIETSGFLCLLDLAQRANPQCQKTEFSESAALETFGWAPELSTVRLDPRLYEGSHADY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSGIETSGFLCLLDLAQRANPQCQKTEFSESAALETFGWAPELSTVRLDPRLYEGSHADY
              530       540       550       560       570       580

        710       720       730       740       750       760      
pF1KSD YSLCSSVSPASYLSDSSESTASRQGGAPPAWGQQGWTEAQPSSMLEPLALHPPLAFEDGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YSLCSSVSPASYLSDSSESTASRQGGAPPAWGQQGWTEAQPSSMLEPLALHPPLAFEDGS
              590       600       610       620       630       640

        770       780       790       800       810       820      
pF1KSD SDEEYYDAADKLTPPGPPSGPRDVSTAEPSATSLQNKASTSSPENSLPCGPDGRQPSRRG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDEEYYDAADKLTPPGPPSGPRDVSTAEPSATSLQNKASTSSPENSLPCGPDGRQPSRRG
              650       660       670       680       690       700

        830       840       850       860       870       880      
pF1KSD GVKKYAKTLRKRRSFLQTDYTSQVSFPLVPSASLESVDDVCYYDREPYLALGAPSPTVSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GVKKYAKTLRKRRSFLQTDYTSQVSFPLVPSASLESVDDVCYYDREPYLALGAPSPTVSS
              710       720       730       740       750       760

        890       900       910       920       930       940      
pF1KSD LQDMQGEPGLLETKALGLLAPLRETKSTNPASRVMEMEPETMETKSVIDSRVSSISAIRF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQDMQGEPGLLETKALGLLAPLRETKSTNPASRVMEMEPETMETKSVIDSRVSSISAIRF
              770       780       790       800       810       820

        950       960       970       980       990      1000      
pF1KSD RIDPNNKENSGVVPAASSSASTPHCSNPGSSGPDTAQARPSQILPLSQDLDGIAPKEPTI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RIDPNNKENSGVVPAASSSASTPHCSNPGSSGPDTAQARPSQILPLSQDLDGIAPKEPTI
              830       840       850       860       870       880

       1010      1020      1030      1040      1050      1060      
pF1KSD EHGDSSFSLSSGDPNPDRACLASNPGLNNVSQGDTLELQLEPHVQLEMGLESFCTNHIQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EHGDSSFSLSSGDPNPDRACLASNPGLNNVSQGDTLELQLEPHVQLEMGLESFCTNHIQE
              890       900       910       920       930       940

       1070      1080      1090      1100      1110      1120      
pF1KSD TAPKYTEPLLSPRDEPRSDECGINPGEKIASIPTKEEPQGQLSLERDREVTNKNGTNVFQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TAPKYTEPLLSPRDEPRSDECGINPGEKIASIPTKEEPQGQLSLERDREVTNKNGTNVFQ
              950       960       970       980       990      1000

       1130      1140      1150      1160      1170      1180      
pF1KSD EESRKDSGDSPGDVSNNVSQTLDISSPAGKIVTSLSLDAPVTGTEQIPPHPPRDPQGQSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EESRKDSGDSPGDVSNNVSQTLDISSPAGKIVTSLSLDAPVTGTEQIPPHPPRDPQGQSR
             1010      1020      1030      1040      1050      1060

       1190      1200      1210      1220      1230      1240      
pF1KSD EPPGQGCQAQEQKLFVELDLDPDFFLGKQTVSPAVPPEGIKAEAPNHVTGQDIAPRDSPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EPPGQGCQAQEQKLFVELDLDPDFFLGKQTVSPAVPPEGIKAEAPNHVTGQDIAPRDSPE
             1070      1080      1090      1100      1110      1120

       1250      1260      1270      1280      1290      1300      
pF1KSD WVCFNPEPSLPEPLPCPQEDPHLETSNHCLLLEGKSDSSSICLSAEKSFLCFAPESHPEV
       ::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::
XP_011 WVCFNPEPSLPEPLPCPQEDPHLETSNHCLLSEGKSDSSSICLSAEKSFLCFAPESHPEV
             1130      1140      1150      1160      1170      1180

       1310      1320      1330      1340      1350      1360      
pF1KSD SASLRVATSLGFAGMNEMVAPRIGMDQCSCQFSYATCFRGPQPETEEEDRDLEAHPMAPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SASLRVATSLGFAGMNEMVAPRIGMDQCSCQFSYATCFRGPQPETEEEDRDLEAHPMAPL
             1190      1200      1210      1220      1230      1240

       1370      1380      1390      1400      1410      1420      
pF1KSD TSPPSAGSPVVLPWRPARAHSCTTAPLSRKSHIWPEYCSRALRQLKATPASTPEGFIQLM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSPPSAGSPVVLPWRPARAHSCTTAPLSRKSHIWPEYCSRALRQLKATPASTPEGFIQLM
             1250      1260      1270      1280      1290      1300

       1430      1440      1450      1460      1470      1480      
pF1KSD ESLLELQDILETSWGVGNKHPPEKCTWHFTESRSRLCMGSQKLLSSCRHVIRMDQSPEEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ESLLELQDILETSWGVGNKHPPEKCTWHFTESRSRLCMGSQKLLSSCRHVIRMDQSPEEM
             1310      1320      1330      1340      1350      1360

       1490      1500      1510      1520      1530      1540      
pF1KSD QGAVRDTFQHLVQLAGLCFQFTDCSRCSARHREAAGNLRDVVYTYHQFIEAAKSTCERGY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QGAVRDTFQHLVQLAGLCFQFTDCSRCSARHREAAGNLRDVVYTYHQFIEAAKSTCERGY
             1370      1380      1390      1400      1410      1420

       1550      1560      1570        
pF1KSD HDLSVKLLARQCTALTAAVFCLTQKFRASTAL
       ::::::::::::::::::::::::::::::::
XP_011 HDLSVKLLARQCTALTAAVFCLTQKFRASTAL
             1430      1440      1450  

>>XP_011516107 (OMIM: 616919) PREDICTED: FERM and PDZ do  (1453 aa)
 initn: 9628 init1: 9628 opt: 9628  Z-score: 6768.9  bits: 1265.2 E(85289):    0
Smith-Waterman score: 9628; 99.9% identity (99.9% similar) in 1442 aa overlap (137-1578:12-1453)

        110       120       130       140       150       160      
pF1KSD PAEDLSWERAVDILREAEDSLSITVVRCTSGVPKSSFLTEEKRARLKTNPVKVHFAEEVL
                                     ::::::::::::::::::::::::::::::
XP_011                    MASALPGQLGPGVPKSSFLTEEKRARLKTNPVKVHFAEEVL
                                  10        20        30        40 

        170       180       190       200       210       220      
pF1KSD ISGHSQGNSLLCMPNVLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ISGHSQGNSLLCMPNVLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALAL
              50        60        70        80        90       100 

        230       240       250       260       270       280      
pF1KSD EEQYSISRLHLLHEEELIQQVVEREESHDYRCLFRVCFVPKDPLDLLKEDPVAFEYLYLQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEQYSISRLHLLHEEELIQQVVEREESHDYRCLFRVCFVPKDPLDLLKEDPVAFEYLYLQ
             110       120       130       140       150       160 

        290       300       310       320       330       340      
pF1KSD SCSDVLQERFAVEMKCSSALRLAALHIQERIYACAQPQKISLKYIEKDWGIENFISPTLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SCSDVLQERFAVEMKCSSALRLAALHIQERIYACAQPQKISLKYIEKDWGIENFISPTLL
             170       180       190       200       210       220 

        350       360       370       380       390       400      
pF1KSD RNMKGKDIKKAISFHMKRNQNLLEPRQKQLISAAQLRLNYLQILGELKTYGGRIFNATLM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RNMKGKDIKKAISFHMKRNQNLLEPRQKQLISAAQLRLNYLQILGELKTYGGRIFNATLM
             230       240       250       260       270       280 

        410       420       430       440       450       460      
pF1KSD LQDRESYIALLVGAKYGISQVINSKLNIMSTLAEFANISRVELTEESEKVSVVKVYLQDV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQDRESYIALLVGAKYGISQVINSKLNIMSTLAEFANISRVELTEESEKVSVVKVYLQDV
             290       300       310       320       330       340 

        470       480       490       500       510       520      
pF1KSD KVLTLLLESNSAKDLACLIAGYYRLLVDPVTSIFLWPGNKQQAHRVSAEEGYESRACSDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVLTLLLESNSAKDLACLIAGYYRLLVDPVTSIFLWPGNKQQAHRVSAEEGYESRACSDS
             350       360       370       380       390       400 

        530       540       550       560       570       580      
pF1KSD EESSEVDCVLEPLSDRRLVKLAPCRSLIKEEQPPGNSPTPEVARRGPSTCGASSTTDSAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EESSEVDCVLEPLSDRRLVKLAPCRSLIKEEQPPGNSPTPEVARRGPSTCGASSTTDSAE
             410       420       430       440       450       460 

        590       600       610       620       630       640      
pF1KSD SEASDSANTESRGYRTSGSSESMDALEEDDLDTCSSSRSTFFHFGSPGLAESIDSDSQEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SEASDSANTESRGYRTSGSSESMDALEEDDLDTCSSSRSTFFHFGSPGLAESIDSDSQEE
             470       480       490       500       510       520 

        650       660       670       680       690       700      
pF1KSD RSGIETSGFLCLLDLAQRANPQCQKTEFSESAALETFGWAPELSTVRLDPRLYEGSHADY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSGIETSGFLCLLDLAQRANPQCQKTEFSESAALETFGWAPELSTVRLDPRLYEGSHADY
             530       540       550       560       570       580 

        710       720       730       740       750       760      
pF1KSD YSLCSSVSPASYLSDSSESTASRQGGAPPAWGQQGWTEAQPSSMLEPLALHPPLAFEDGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YSLCSSVSPASYLSDSSESTASRQGGAPPAWGQQGWTEAQPSSMLEPLALHPPLAFEDGS
             590       600       610       620       630       640 

        770       780       790       800       810       820      
pF1KSD SDEEYYDAADKLTPPGPPSGPRDVSTAEPSATSLQNKASTSSPENSLPCGPDGRQPSRRG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDEEYYDAADKLTPPGPPSGPRDVSTAEPSATSLQNKASTSSPENSLPCGPDGRQPSRRG
             650       660       670       680       690       700 

        830       840       850       860       870       880      
pF1KSD GVKKYAKTLRKRRSFLQTDYTSQVSFPLVPSASLESVDDVCYYDREPYLALGAPSPTVSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GVKKYAKTLRKRRSFLQTDYTSQVSFPLVPSASLESVDDVCYYDREPYLALGAPSPTVSS
             710       720       730       740       750       760 

        890       900       910       920       930       940      
pF1KSD LQDMQGEPGLLETKALGLLAPLRETKSTNPASRVMEMEPETMETKSVIDSRVSSISAIRF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQDMQGEPGLLETKALGLLAPLRETKSTNPASRVMEMEPETMETKSVIDSRVSSISAIRF
             770       780       790       800       810       820 

        950       960       970       980       990      1000      
pF1KSD RIDPNNKENSGVVPAASSSASTPHCSNPGSSGPDTAQARPSQILPLSQDLDGIAPKEPTI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RIDPNNKENSGVVPAASSSASTPHCSNPGSSGPDTAQARPSQILPLSQDLDGIAPKEPTI
             830       840       850       860       870       880 

       1010      1020      1030      1040      1050      1060      
pF1KSD EHGDSSFSLSSGDPNPDRACLASNPGLNNVSQGDTLELQLEPHVQLEMGLESFCTNHIQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EHGDSSFSLSSGDPNPDRACLASNPGLNNVSQGDTLELQLEPHVQLEMGLESFCTNHIQE
             890       900       910       920       930       940 

       1070      1080      1090      1100      1110      1120      
pF1KSD TAPKYTEPLLSPRDEPRSDECGINPGEKIASIPTKEEPQGQLSLERDREVTNKNGTNVFQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TAPKYTEPLLSPRDEPRSDECGINPGEKIASIPTKEEPQGQLSLERDREVTNKNGTNVFQ
             950       960       970       980       990      1000 

       1130      1140      1150      1160      1170      1180      
pF1KSD EESRKDSGDSPGDVSNNVSQTLDISSPAGKIVTSLSLDAPVTGTEQIPPHPPRDPQGQSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EESRKDSGDSPGDVSNNVSQTLDISSPAGKIVTSLSLDAPVTGTEQIPPHPPRDPQGQSR
            1010      1020      1030      1040      1050      1060 

       1190      1200      1210      1220      1230      1240      
pF1KSD EPPGQGCQAQEQKLFVELDLDPDFFLGKQTVSPAVPPEGIKAEAPNHVTGQDIAPRDSPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EPPGQGCQAQEQKLFVELDLDPDFFLGKQTVSPAVPPEGIKAEAPNHVTGQDIAPRDSPE
            1070      1080      1090      1100      1110      1120 

       1250      1260      1270      1280      1290      1300      
pF1KSD WVCFNPEPSLPEPLPCPQEDPHLETSNHCLLLEGKSDSSSICLSAEKSFLCFAPESHPEV
       ::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::
XP_011 WVCFNPEPSLPEPLPCPQEDPHLETSNHCLLSEGKSDSSSICLSAEKSFLCFAPESHPEV
            1130      1140      1150      1160      1170      1180 

       1310      1320      1330      1340      1350      1360      
pF1KSD SASLRVATSLGFAGMNEMVAPRIGMDQCSCQFSYATCFRGPQPETEEEDRDLEAHPMAPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SASLRVATSLGFAGMNEMVAPRIGMDQCSCQFSYATCFRGPQPETEEEDRDLEAHPMAPL
            1190      1200      1210      1220      1230      1240 

       1370      1380      1390      1400      1410      1420      
pF1KSD TSPPSAGSPVVLPWRPARAHSCTTAPLSRKSHIWPEYCSRALRQLKATPASTPEGFIQLM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSPPSAGSPVVLPWRPARAHSCTTAPLSRKSHIWPEYCSRALRQLKATPASTPEGFIQLM
            1250      1260      1270      1280      1290      1300 

       1430      1440      1450      1460      1470      1480      
pF1KSD ESLLELQDILETSWGVGNKHPPEKCTWHFTESRSRLCMGSQKLLSSCRHVIRMDQSPEEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ESLLELQDILETSWGVGNKHPPEKCTWHFTESRSRLCMGSQKLLSSCRHVIRMDQSPEEM
            1310      1320      1330      1340      1350      1360 

       1490      1500      1510      1520      1530      1540      
pF1KSD QGAVRDTFQHLVQLAGLCFQFTDCSRCSARHREAAGNLRDVVYTYHQFIEAAKSTCERGY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QGAVRDTFQHLVQLAGLCFQFTDCSRCSARHREAAGNLRDVVYTYHQFIEAAKSTCERGY
            1370      1380      1390      1400      1410      1420 

       1550      1560      1570        
pF1KSD HDLSVKLLARQCTALTAAVFCLTQKFRASTAL
       ::::::::::::::::::::::::::::::::
XP_011 HDLSVKLLARQCTALTAAVFCLTQKFRASTAL
            1430      1440      1450   

>>XP_016869971 (OMIM: 616919) PREDICTED: FERM and PDZ do  (1453 aa)
 initn: 9628 init1: 9628 opt: 9628  Z-score: 6768.9  bits: 1265.2 E(85289):    0
Smith-Waterman score: 9628; 99.9% identity (99.9% similar) in 1442 aa overlap (137-1578:12-1453)

        110       120       130       140       150       160      
pF1KSD PAEDLSWERAVDILREAEDSLSITVVRCTSGVPKSSFLTEEKRARLKTNPVKVHFAEEVL
                                     ::::::::::::::::::::::::::::::
XP_016                    MASALPGQLGPGVPKSSFLTEEKRARLKTNPVKVHFAEEVL
                                  10        20        30        40 

        170       180       190       200       210       220      
pF1KSD ISGHSQGNSLLCMPNVLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ISGHSQGNSLLCMPNVLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALAL
              50        60        70        80        90       100 

        230       240       250       260       270       280      
pF1KSD EEQYSISRLHLLHEEELIQQVVEREESHDYRCLFRVCFVPKDPLDLLKEDPVAFEYLYLQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEQYSISRLHLLHEEELIQQVVEREESHDYRCLFRVCFVPKDPLDLLKEDPVAFEYLYLQ
             110       120       130       140       150       160 

        290       300       310       320       330       340      
pF1KSD SCSDVLQERFAVEMKCSSALRLAALHIQERIYACAQPQKISLKYIEKDWGIENFISPTLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SCSDVLQERFAVEMKCSSALRLAALHIQERIYACAQPQKISLKYIEKDWGIENFISPTLL
             170       180       190       200       210       220 

        350       360       370       380       390       400      
pF1KSD RNMKGKDIKKAISFHMKRNQNLLEPRQKQLISAAQLRLNYLQILGELKTYGGRIFNATLM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RNMKGKDIKKAISFHMKRNQNLLEPRQKQLISAAQLRLNYLQILGELKTYGGRIFNATLM
             230       240       250       260       270       280 

        410       420       430       440       450       460      
pF1KSD LQDRESYIALLVGAKYGISQVINSKLNIMSTLAEFANISRVELTEESEKVSVVKVYLQDV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQDRESYIALLVGAKYGISQVINSKLNIMSTLAEFANISRVELTEESEKVSVVKVYLQDV
             290       300       310       320       330       340 

        470       480       490       500       510       520      
pF1KSD KVLTLLLESNSAKDLACLIAGYYRLLVDPVTSIFLWPGNKQQAHRVSAEEGYESRACSDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KVLTLLLESNSAKDLACLIAGYYRLLVDPVTSIFLWPGNKQQAHRVSAEEGYESRACSDS
             350       360       370       380       390       400 

        530       540       550       560       570       580      
pF1KSD EESSEVDCVLEPLSDRRLVKLAPCRSLIKEEQPPGNSPTPEVARRGPSTCGASSTTDSAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EESSEVDCVLEPLSDRRLVKLAPCRSLIKEEQPPGNSPTPEVARRGPSTCGASSTTDSAE
             410       420       430       440       450       460 

        590       600       610       620       630       640      
pF1KSD SEASDSANTESRGYRTSGSSESMDALEEDDLDTCSSSRSTFFHFGSPGLAESIDSDSQEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SEASDSANTESRGYRTSGSSESMDALEEDDLDTCSSSRSTFFHFGSPGLAESIDSDSQEE
             470       480       490       500       510       520 

        650       660       670       680       690       700      
pF1KSD RSGIETSGFLCLLDLAQRANPQCQKTEFSESAALETFGWAPELSTVRLDPRLYEGSHADY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSGIETSGFLCLLDLAQRANPQCQKTEFSESAALETFGWAPELSTVRLDPRLYEGSHADY
             530       540       550       560       570       580 

        710       720       730       740       750       760      
pF1KSD YSLCSSVSPASYLSDSSESTASRQGGAPPAWGQQGWTEAQPSSMLEPLALHPPLAFEDGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YSLCSSVSPASYLSDSSESTASRQGGAPPAWGQQGWTEAQPSSMLEPLALHPPLAFEDGS
             590       600       610       620       630       640 

        770       780       790       800       810       820      
pF1KSD SDEEYYDAADKLTPPGPPSGPRDVSTAEPSATSLQNKASTSSPENSLPCGPDGRQPSRRG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SDEEYYDAADKLTPPGPPSGPRDVSTAEPSATSLQNKASTSSPENSLPCGPDGRQPSRRG
             650       660       670       680       690       700 

        830       840       850       860       870       880      
pF1KSD GVKKYAKTLRKRRSFLQTDYTSQVSFPLVPSASLESVDDVCYYDREPYLALGAPSPTVSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GVKKYAKTLRKRRSFLQTDYTSQVSFPLVPSASLESVDDVCYYDREPYLALGAPSPTVSS
             710       720       730       740       750       760 

        890       900       910       920       930       940      
pF1KSD LQDMQGEPGLLETKALGLLAPLRETKSTNPASRVMEMEPETMETKSVIDSRVSSISAIRF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQDMQGEPGLLETKALGLLAPLRETKSTNPASRVMEMEPETMETKSVIDSRVSSISAIRF
             770       780       790       800       810       820 

        950       960       970       980       990      1000      
pF1KSD RIDPNNKENSGVVPAASSSASTPHCSNPGSSGPDTAQARPSQILPLSQDLDGIAPKEPTI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RIDPNNKENSGVVPAASSSASTPHCSNPGSSGPDTAQARPSQILPLSQDLDGIAPKEPTI
             830       840       850       860       870       880 

       1010      1020      1030      1040      1050      1060      
pF1KSD EHGDSSFSLSSGDPNPDRACLASNPGLNNVSQGDTLELQLEPHVQLEMGLESFCTNHIQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EHGDSSFSLSSGDPNPDRACLASNPGLNNVSQGDTLELQLEPHVQLEMGLESFCTNHIQE
             890       900       910       920       930       940 

       1070      1080      1090      1100      1110      1120      
pF1KSD TAPKYTEPLLSPRDEPRSDECGINPGEKIASIPTKEEPQGQLSLERDREVTNKNGTNVFQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TAPKYTEPLLSPRDEPRSDECGINPGEKIASIPTKEEPQGQLSLERDREVTNKNGTNVFQ
             950       960       970       980       990      1000 

       1130      1140      1150      1160      1170      1180      
pF1KSD EESRKDSGDSPGDVSNNVSQTLDISSPAGKIVTSLSLDAPVTGTEQIPPHPPRDPQGQSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EESRKDSGDSPGDVSNNVSQTLDISSPAGKIVTSLSLDAPVTGTEQIPPHPPRDPQGQSR
            1010      1020      1030      1040      1050      1060 

       1190      1200      1210      1220      1230      1240      
pF1KSD EPPGQGCQAQEQKLFVELDLDPDFFLGKQTVSPAVPPEGIKAEAPNHVTGQDIAPRDSPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EPPGQGCQAQEQKLFVELDLDPDFFLGKQTVSPAVPPEGIKAEAPNHVTGQDIAPRDSPE
            1070      1080      1090      1100      1110      1120 

       1250      1260      1270      1280      1290      1300      
pF1KSD WVCFNPEPSLPEPLPCPQEDPHLETSNHCLLLEGKSDSSSICLSAEKSFLCFAPESHPEV
       ::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::
XP_016 WVCFNPEPSLPEPLPCPQEDPHLETSNHCLLSEGKSDSSSICLSAEKSFLCFAPESHPEV
            1130      1140      1150      1160      1170      1180 

       1310      1320      1330      1340      1350      1360      
pF1KSD SASLRVATSLGFAGMNEMVAPRIGMDQCSCQFSYATCFRGPQPETEEEDRDLEAHPMAPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SASLRVATSLGFAGMNEMVAPRIGMDQCSCQFSYATCFRGPQPETEEEDRDLEAHPMAPL
            1190      1200      1210      1220      1230      1240 

       1370      1380      1390      1400      1410      1420      
pF1KSD TSPPSAGSPVVLPWRPARAHSCTTAPLSRKSHIWPEYCSRALRQLKATPASTPEGFIQLM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSPPSAGSPVVLPWRPARAHSCTTAPLSRKSHIWPEYCSRALRQLKATPASTPEGFIQLM
            1250      1260      1270      1280      1290      1300 

       1430      1440      1450      1460      1470      1480      
pF1KSD ESLLELQDILETSWGVGNKHPPEKCTWHFTESRSRLCMGSQKLLSSCRHVIRMDQSPEEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESLLELQDILETSWGVGNKHPPEKCTWHFTESRSRLCMGSQKLLSSCRHVIRMDQSPEEM
            1310      1320      1330      1340      1350      1360 

       1490      1500      1510      1520      1530      1540      
pF1KSD QGAVRDTFQHLVQLAGLCFQFTDCSRCSARHREAAGNLRDVVYTYHQFIEAAKSTCERGY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QGAVRDTFQHLVQLAGLCFQFTDCSRCSARHREAAGNLRDVVYTYHQFIEAAKSTCERGY
            1370      1380      1390      1400      1410      1420 

       1550      1560      1570        
pF1KSD HDLSVKLLARQCTALTAAVFCLTQKFRASTAL
       ::::::::::::::::::::::::::::::::
XP_016 HDLSVKLLARQCTALTAAVFCLTQKFRASTAL
            1430      1440      1450   

>>XP_016869970 (OMIM: 616919) PREDICTED: FERM and PDZ do  (1469 aa)
 initn: 9628 init1: 9628 opt: 9628  Z-score: 6768.8  bits: 1265.2 E(85289):    0
Smith-Waterman score: 9628; 99.9% identity (99.9% similar) in 1442 aa overlap (137-1578:28-1469)

        110       120       130       140       150       160      
pF1KSD PAEDLSWERAVDILREAEDSLSITVVRCTSGVPKSSFLTEEKRARLKTNPVKVHFAEEVL
                                     ::::::::::::::::::::::::::::::
XP_016    MAEVGVSRWFIICSRCQDIHGSRADVQGVPKSSFLTEEKRARLKTNPVKVHFAEEVL
                  10        20        30        40        50       

        170       180       190       200       210       220      
pF1KSD ISGHSQGNSLLCMPNVLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ISGHSQGNSLLCMPNVLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALAL
        60        70        80        90       100       110       

        230       240       250       260       270       280      
pF1KSD EEQYSISRLHLLHEEELIQQVVEREESHDYRCLFRVCFVPKDPLDLLKEDPVAFEYLYLQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEQYSISRLHLLHEEELIQQVVEREESHDYRCLFRVCFVPKDPLDLLKEDPVAFEYLYLQ
       120       130       140       150       160       170       

        290       300       310       320       330       340      
pF1KSD SCSDVLQERFAVEMKCSSALRLAALHIQERIYACAQPQKISLKYIEKDWGIENFISPTLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SCSDVLQERFAVEMKCSSALRLAALHIQERIYACAQPQKISLKYIEKDWGIENFISPTLL
       180       190       200       210       220       230       

        350       360       370       380       390       400      
pF1KSD RNMKGKDIKKAISFHMKRNQNLLEPRQKQLISAAQLRLNYLQILGELKTYGGRIFNATLM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RNMKGKDIKKAISFHMKRNQNLLEPRQKQLISAAQLRLNYLQILGELKTYGGRIFNATLM
       240       250       260       270       280       290       

        410       420       430       440       450       460      
pF1KSD LQDRESYIALLVGAKYGISQVINSKLNIMSTLAEFANISRVELTEESEKVSVVKVYLQDV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQDRESYIALLVGAKYGISQVINSKLNIMSTLAEFANISRVELTEESEKVSVVKVYLQDV
       300       310       320       330       340       350       

        470       480       490       500       510       520      
pF1KSD KVLTLLLESNSAKDLACLIAGYYRLLVDPVTSIFLWPGNKQQAHRVSAEEGYESRACSDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KVLTLLLESNSAKDLACLIAGYYRLLVDPVTSIFLWPGNKQQAHRVSAEEGYESRACSDS
       360       370       380       390       400       410       

        530       540       550       560       570       580      
pF1KSD EESSEVDCVLEPLSDRRLVKLAPCRSLIKEEQPPGNSPTPEVARRGPSTCGASSTTDSAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EESSEVDCVLEPLSDRRLVKLAPCRSLIKEEQPPGNSPTPEVARRGPSTCGASSTTDSAE
       420       430       440       450       460       470       

        590       600       610       620       630       640      
pF1KSD SEASDSANTESRGYRTSGSSESMDALEEDDLDTCSSSRSTFFHFGSPGLAESIDSDSQEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SEASDSANTESRGYRTSGSSESMDALEEDDLDTCSSSRSTFFHFGSPGLAESIDSDSQEE
       480       490       500       510       520       530       

        650       660       670       680       690       700      
pF1KSD RSGIETSGFLCLLDLAQRANPQCQKTEFSESAALETFGWAPELSTVRLDPRLYEGSHADY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSGIETSGFLCLLDLAQRANPQCQKTEFSESAALETFGWAPELSTVRLDPRLYEGSHADY
       540       550       560       570       580       590       

        710       720       730       740       750       760      
pF1KSD YSLCSSVSPASYLSDSSESTASRQGGAPPAWGQQGWTEAQPSSMLEPLALHPPLAFEDGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YSLCSSVSPASYLSDSSESTASRQGGAPPAWGQQGWTEAQPSSMLEPLALHPPLAFEDGS
       600       610       620       630       640       650       

        770       780       790       800       810       820      
pF1KSD SDEEYYDAADKLTPPGPPSGPRDVSTAEPSATSLQNKASTSSPENSLPCGPDGRQPSRRG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SDEEYYDAADKLTPPGPPSGPRDVSTAEPSATSLQNKASTSSPENSLPCGPDGRQPSRRG
       660       670       680       690       700       710       

        830       840       850       860       870       880      
pF1KSD GVKKYAKTLRKRRSFLQTDYTSQVSFPLVPSASLESVDDVCYYDREPYLALGAPSPTVSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GVKKYAKTLRKRRSFLQTDYTSQVSFPLVPSASLESVDDVCYYDREPYLALGAPSPTVSS
       720       730       740       750       760       770       

        890       900       910       920       930       940      
pF1KSD LQDMQGEPGLLETKALGLLAPLRETKSTNPASRVMEMEPETMETKSVIDSRVSSISAIRF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQDMQGEPGLLETKALGLLAPLRETKSTNPASRVMEMEPETMETKSVIDSRVSSISAIRF
       780       790       800       810       820       830       

        950       960       970       980       990      1000      
pF1KSD RIDPNNKENSGVVPAASSSASTPHCSNPGSSGPDTAQARPSQILPLSQDLDGIAPKEPTI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RIDPNNKENSGVVPAASSSASTPHCSNPGSSGPDTAQARPSQILPLSQDLDGIAPKEPTI
       840       850       860       870       880       890       

       1010      1020      1030      1040      1050      1060      
pF1KSD EHGDSSFSLSSGDPNPDRACLASNPGLNNVSQGDTLELQLEPHVQLEMGLESFCTNHIQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EHGDSSFSLSSGDPNPDRACLASNPGLNNVSQGDTLELQLEPHVQLEMGLESFCTNHIQE
       900       910       920       930       940       950       

       1070      1080      1090      1100      1110      1120      
pF1KSD TAPKYTEPLLSPRDEPRSDECGINPGEKIASIPTKEEPQGQLSLERDREVTNKNGTNVFQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TAPKYTEPLLSPRDEPRSDECGINPGEKIASIPTKEEPQGQLSLERDREVTNKNGTNVFQ
       960       970       980       990      1000      1010       

       1130      1140      1150      1160      1170      1180      
pF1KSD EESRKDSGDSPGDVSNNVSQTLDISSPAGKIVTSLSLDAPVTGTEQIPPHPPRDPQGQSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EESRKDSGDSPGDVSNNVSQTLDISSPAGKIVTSLSLDAPVTGTEQIPPHPPRDPQGQSR
      1020      1030      1040      1050      1060      1070       

       1190      1200      1210      1220      1230      1240      
pF1KSD EPPGQGCQAQEQKLFVELDLDPDFFLGKQTVSPAVPPEGIKAEAPNHVTGQDIAPRDSPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EPPGQGCQAQEQKLFVELDLDPDFFLGKQTVSPAVPPEGIKAEAPNHVTGQDIAPRDSPE
      1080      1090      1100      1110      1120      1130       

       1250      1260      1270      1280      1290      1300      
pF1KSD WVCFNPEPSLPEPLPCPQEDPHLETSNHCLLLEGKSDSSSICLSAEKSFLCFAPESHPEV
       ::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::
XP_016 WVCFNPEPSLPEPLPCPQEDPHLETSNHCLLSEGKSDSSSICLSAEKSFLCFAPESHPEV
      1140      1150      1160      1170      1180      1190       

       1310      1320      1330      1340      1350      1360      
pF1KSD SASLRVATSLGFAGMNEMVAPRIGMDQCSCQFSYATCFRGPQPETEEEDRDLEAHPMAPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SASLRVATSLGFAGMNEMVAPRIGMDQCSCQFSYATCFRGPQPETEEEDRDLEAHPMAPL
      1200      1210      1220      1230      1240      1250       

       1370      1380      1390      1400      1410      1420      
pF1KSD TSPPSAGSPVVLPWRPARAHSCTTAPLSRKSHIWPEYCSRALRQLKATPASTPEGFIQLM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSPPSAGSPVVLPWRPARAHSCTTAPLSRKSHIWPEYCSRALRQLKATPASTPEGFIQLM
      1260      1270      1280      1290      1300      1310       

       1430      1440      1450      1460      1470      1480      
pF1KSD ESLLELQDILETSWGVGNKHPPEKCTWHFTESRSRLCMGSQKLLSSCRHVIRMDQSPEEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESLLELQDILETSWGVGNKHPPEKCTWHFTESRSRLCMGSQKLLSSCRHVIRMDQSPEEM
      1320      1330      1340      1350      1360      1370       

       1490      1500      1510      1520      1530      1540      
pF1KSD QGAVRDTFQHLVQLAGLCFQFTDCSRCSARHREAAGNLRDVVYTYHQFIEAAKSTCERGY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QGAVRDTFQHLVQLAGLCFQFTDCSRCSARHREAAGNLRDVVYTYHQFIEAAKSTCERGY
      1380      1390      1400      1410      1420      1430       

       1550      1560      1570        
pF1KSD HDLSVKLLARQCTALTAAVFCLTQKFRASTAL
       ::::::::::::::::::::::::::::::::
XP_016 HDLSVKLLARQCTALTAAVFCLTQKFRASTAL
      1440      1450      1460         

>>XP_016885475 (OMIM: 300830,300838,300983) PREDICTED: F  (1319 aa)
 initn: 927 init1: 557 opt: 1515  Z-score: 1070.5  bits: 210.7 E(85289): 6.9e-53
Smith-Waterman score: 1538; 30.3% identity (58.9% similar) in 1295 aa overlap (41-1257:59-1289)

               20        30        40        50        60        70
pF1KSD TRKAHRIEQMVARWLRRSRDSSARAKVAAADGPARNPTQTLIPVRHTVKIDKDTLLQDYG
                                     : :  .  : . :. . :.. .: .:  .:
XP_016 SQVPPYGWEMTANRDGRDYFINHMTQAIPFDDPRLESCQIIPPAPRKVEMRRDPVL-GFG
       30        40        50        60        70        80        

               80        90       100       110       120       130
pF1KSD FHISESLPLTVVAVTAGGSAHGKLFPGDQILQMNNEPAEDLSWERAVDILREAEDSLSIT
       :  .   :..: .:: :: ..:::.:::::...:.::.     ::..:..:  ..:. .:
XP_016 FVAGSEKPVVVRSVTPGGPSEGKLIPGDQIVMINDEPVSAAPRERVIDLVRSCKESILLT
        90       100       110       120       130       140       

              140       150       160       170           180      
pF1KSD VVRCTSGVPKSSFLTEEKRARLKTNPVKVHFAEEVLISGHS----QGNSLLCMPNVLKLY
       :..     :::.:..  :.::::.:::::.:.:::.:.:.     . :::: ::::::.:
XP_016 VIQ-PYPSPKSAFISAAKKARLKSNPVKVRFSEEVIINGQVSETVKDNSLLFMPNVLKVY
       150        160       170       180       190       200      

        190       200       210       220       230         240    
pF1KSD LENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALALEEQY--SISRLHLLHEEELI
       :::::::.:.:. .:..::.:::..:::::..::.:.: ::..   . ..: ::::.: .
XP_016 LENGQTKSFRFDCSTSIKDVILTLQEKLSIKGIEHFSLMLEQRTEGAGTKLLLLHEQETL
        210       220       230       240       250       260      

          250       260       270       280       290       300    
pF1KSD QQVVEREESHDYRCLFRVCFVPKDPLDLLKEDPVAFEYLYLQSCSDVLQERFAVEMKCSS
        ::..:  :: .:::::. ::::::.:::..:::::::::.:::.::.::::. :.: . 
XP_016 TQVTQRPSSHKMRCLFRISFVPKDPIDLLRRDPVAFEYLYVQSCNDVVQERFGPELKYDI
        270       280       290       300       310       320      

          310       320       330       340       350       360    
pF1KSD ALRLAALHIQERIYACAQPQKISLKYIEKDWGIENFISPTLLRNMKGKDIKKAISFHMKR
       :::::::..     .  : ::::::::::.::.:.:.  ..:..:: :.::::.:  .: 
XP_016 ALRLAALQMYIATVTTKQTQKISLKYIEKEWGLETFLPSAVLQSMKEKNIKKALSHLVKA
        330       340       350       360       370       380      

          370       380       390       400       410       420    
pF1KSD NQNLLEPRQKQLISAAQLRLNYLQILGELKTYGGRIFNATLMLQDRESYIALLVGAKYGI
       ::::. : .:  .:: : ...::..:..:. ::::.:.:::.  ...: ..:::: .:::
XP_016 NQNLVPPGKK--LSALQAKVHYLKFLSDLRLYGGRVFKATLVQAEKRSEVTLLVGPRYGI
        390         400       410       420       430       440    

          430       440       450       460       470       480    
pF1KSD SQVINSKLNIMSTLAEFANISRVELTEESEKVSVVKVYLQDVKVLTLLLESNSAKDLACL
       :.:::.: :... ::.:....:.:.  : :..  :.... ::: .:::.::..: .::::
XP_016 SHVINTKTNLVALLADFSHVNRIEMFSEEESLVRVELHVLDVKPITLLMESSDAMNLACL
          450       460       470       480       490       500    

          490       500       510       520       530       540    
pF1KSD IAGYYRLLVDPVTSIFLWPGNKQQAHRVSAEEGYESRACSDSEESSEVDCVLEPLS----
        :::::::::   :::   ..:. :   . : : :... . .  . . .:. .  .    
XP_016 TAGYYRLLVDSRRSIFNMANKKNTA---TQETGPENKG-KHNLLGPDWNCIPQMTTFIGE
          510       520          530        540       550       560

              550       560       570            580       590     
pF1KSD DRRLVKLAPCRSLIKEEQPPGNSPTPEVARR-----GPSTCGASSTTDSAESEASDSANT
        .. ....   :  :  .   ..  :.  :.     . :. : ..   :  .::   :. 
XP_016 GEQEAQITYIDSKQKTVEITDSTMCPKEHRHLYIDNAYSSDGLNQQL-SQPGEAPCEADY
              570       580       590       600        610         

         600       610       620       630       640       650     
pF1KSD ESRGYRTSGSSESMDALEEDDLDTCSSSRSTFFHFGSPGLAESIDSDSQEERSGIETSGF
       .: . :.  .  . ..:.. . ..  ... .:. ::. .: ..:.           : :.
XP_016 RSLAQRSLLTLSGPETLKKAQ-ESPRGAKVSFI-FGDFALDDGISPP---------TLGY
     620       630       640        650        660                 

         660       670       680       690                 700     
pF1KSD LCLLDLAQRANPQCQKTEFSESAALETFGWAPELSTVRL----------DPRLYEGSHAD
         ::: . .   . ..  .. .  .. .  .::   ...          : . ...... 
XP_016 ETLLDEGPEMLEKQRNLYIGSANDMKGLDLTPEAEGIQFVENSVYANIGDVKSFQAAEGI
      670       680       690       700       710       720        

         710       720         730       740         750       760 
pF1KSD YYSLCSSVSPASYLSDSSES--TASRQGGAPPAWGQQGWTEAQPSS--MLEPLALHPPLA
          :  ..  :   .:. .   .. ..  .    .: .  . . ::  ...  .: ::  
XP_016 EEPLLHDICYAENTDDAEDEDEVSCEEDLVVGEMNQPAILNLSGSSDDIIDLTSLPPP--
      730       740       750       760       770       780        

             770       780       790                    800        
pF1KSD FEDGSSDEEYYDAADKLTPPGPPSGPRDVSTAEPS-------------ATSLQNKASTSS
        :  ......   . ...  .:: : :: :  : :             ..::::     :
XP_016 -EGDDNEDDFLLRSLNMAIAAPPPGFRDSSDEEDSQSQAASFPEDKEKGSSLQNDEIPVS
         790       800       810       820       830       840     

      810       820       830       840            850         860 
pF1KSD PENSLPCGPDGRQPSRRGGVKKYAKTLRKRRSF-----LQTDYTSQVSF--PLVPSASLE
         ...: . .:.   ..:  .  ..::   ...      ::. .: :..     : .: .
XP_016 LIDAVPTSAEGK--CEKGLDNAVVSTLGALEALSVSEEQQTSDNSGVAILRAYSPESSSD
         850         860       870       880       890       900   

             870       880       890       900       910       920 
pF1KSD SVDDVCYYDREPYLALGAPSPTVSSLQDMQGEPGLLETKALGLLAPLRETKSTNPASRV-
       : ...   .      :.. .    .:. :     .: :.  :   :: : ..  :::.. 
XP_016 SGNETNSSEMTESSELATAQKQSENLSRM-----FLATHE-GY-HPLAEEQTEFPASKTP
           910       920       930             940        950      

                         930       940       950       960         
pF1KSD -----------MEMEPETMETKSVIDSRVSSISAIRFRIDPNNKENSGVVPAASSSASTP
                  .  .: :    .:. :. . . . .....:.. :...:    ..  :  
XP_016 AGGLPPKSSHALAARPATDLPPKVVPSK-QLLHSDHMEMEPETMETKSV----TDYFSKL
        960       970       980        990      1000          1010 

     970       980       990      1000      1010      1020         
pF1KSD HCSNPGSSGPDTAQARPSQILPLSQDLDGIAPKEPTIEHGDSSFSLSSGDPNPDRACLAS
       :    :: . . .. : :..     : .: ::  :   .:... . ..:  . .    ::
XP_016 HM---GSVAYSCTSKRKSKL----ADGEGKAP--P---NGNTTGKKQQGTKTAEMEEEAS
               1020          1030           1040      1050         

    1030      1040         1050      1060      1070      1080      
pF1KSD NPGLNNVSQGDTLELQ---LEPHVQLEMGLESFCTNHIQETAPKYTEPLLSPRDEPRSDE
       .  ...::. :. .:.   :: .. ..   . . .      : :      . .  ::.. 
XP_016 GK-FGTVSSRDSQHLSTFNLE-RTAFRKDSQRWYVATEGGMAEKSGLEAATGKTFPRASG
    1060       1070       1080      1090      1100      1110       

       1090       1100      1110      1120      1130      1140     
pF1KSD CGINPGE-KIASIPTKEEPQGQLSLERDREVTNKNGTNVFQEESRKDSGDSPGDVSNNVS
        :   .: :  . :  :  .:.   . :: .:.     :    : ::  :.: :..... 
XP_016 LGAREAEGKEEGAPDGETSDGSGLGQGDRFLTD-----VTCASSAKDL-DNPEDADSSTC
      1120      1130      1140      1150           1160       1170 

        1150      1160         1170       1180       1190      1200
pF1KSD QTLDISSPAGKIVTSLSLD---APVTGTEQIPPHPP-RDPQGQSREPP-GQGCQAQEQKL
       .  .    : . :. :  :   :   .. :   :   .. ::.: .   : : ...    
XP_016 DHPSKLPEADESVARLC-DYHLAKRMSSLQSEGHFSLQSSQGSSVDAGCGTGSSGSACAT
            1180       1190      1200      1210      1220      1230

             1210      1220             1230       1240      1250  
pF1KSD FVELDLDPDFFLGKQTVSPA-------VPPEGIKAEAPNH-VTGQDIAPRDSPEWVCFNP
        ::  : :.  :::. .  :       .: :      ::: .: ... :.   : .:  :
XP_016 PVESPLCPS--LGKHLIPDASGKGVNYIPSEERAPGLPNHGATFKELHPQ--TEGMC--P
               1240      1250      1260      1270        1280      

           1260      1270      1280      1290      1300      1310  
pF1KSD EPSLPEPLPCPQEDPHLETSNHCLLLEGKSDSSSICLSAEKSFLCFAPESHPEVSASLRV
       . ..:                                                       
XP_016 RMTVPALHTAINTEPLFGTLRDGCHRLPKIKETTV                         
         1290      1300      1310                                  

>>NP_055543 (OMIM: 300830,300838,300983) FERM and PDZ do  (1322 aa)
 initn: 927 init1: 557 opt: 1515  Z-score: 1070.5  bits: 210.7 E(85289): 6.9e-53
Smith-Waterman score: 1538; 30.3% identity (58.9% similar) in 1295 aa overlap (41-1257:62-1292)

               20        30        40        50        60        70
pF1KSD TRKAHRIEQMVARWLRRSRDSSARAKVAAADGPARNPTQTLIPVRHTVKIDKDTLLQDYG
                                     : :  .  : . :. . :.. .: .:  .:
NP_055 SQVPPYGWEMTANRDGRDYFINHMTQAIPFDDPRLESCQIIPPAPRKVEMRRDPVL-GFG
              40        50        60        70        80         90

               80        90       100       110       120       130
pF1KSD FHISESLPLTVVAVTAGGSAHGKLFPGDQILQMNNEPAEDLSWERAVDILREAEDSLSIT
       :  .   :..: .:: :: ..:::.:::::...:.::.     ::..:..:  ..:. .:
NP_055 FVAGSEKPVVVRSVTPGGPSEGKLIPGDQIVMINDEPVSAAPRERVIDLVRSCKESILLT
              100       110       120       130       140       150

              140       150       160       170           180      
pF1KSD VVRCTSGVPKSSFLTEEKRARLKTNPVKVHFAEEVLISGHS----QGNSLLCMPNVLKLY
       :..     :::.:..  :.::::.:::::.:.:::.:.:.     . :::: ::::::.:
NP_055 VIQ-PYPSPKSAFISAAKKARLKSNPVKVRFSEEVIINGQVSETVKDNSLLFMPNVLKVY
               160       170       180       190       200         

        190       200       210       220       230         240    
pF1KSD LENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALALEEQY--SISRLHLLHEEELI
       :::::::.:.:. .:..::.:::..:::::..::.:.: ::..   . ..: ::::.: .
NP_055 LENGQTKSFRFDCSTSIKDVILTLQEKLSIKGIEHFSLMLEQRTEGAGTKLLLLHEQETL
     210       220       230       240       250       260         

          250       260       270       280       290       300    
pF1KSD QQVVEREESHDYRCLFRVCFVPKDPLDLLKEDPVAFEYLYLQSCSDVLQERFAVEMKCSS
        ::..:  :: .:::::. ::::::.:::..:::::::::.:::.::.::::. :.: . 
NP_055 TQVTQRPSSHKMRCLFRISFVPKDPIDLLRRDPVAFEYLYVQSCNDVVQERFGPELKYDI
     270       280       290       300       310       320         

          310       320       330       340       350       360    
pF1KSD ALRLAALHIQERIYACAQPQKISLKYIEKDWGIENFISPTLLRNMKGKDIKKAISFHMKR
       :::::::..     .  : ::::::::::.::.:.:.  ..:..:: :.::::.:  .: 
NP_055 ALRLAALQMYIATVTTKQTQKISLKYIEKEWGLETFLPSAVLQSMKEKNIKKALSHLVKA
     330       340       350       360       370       380         

          370       380       390       400       410       420    
pF1KSD NQNLLEPRQKQLISAAQLRLNYLQILGELKTYGGRIFNATLMLQDRESYIALLVGAKYGI
       ::::. : .:  .:: : ...::..:..:. ::::.:.:::.  ...: ..:::: .:::
NP_055 NQNLVPPGKK--LSALQAKVHYLKFLSDLRLYGGRVFKATLVQAEKRSEVTLLVGPRYGI
     390         400       410       420       430       440       

          430       440       450       460       470       480    
pF1KSD SQVINSKLNIMSTLAEFANISRVELTEESEKVSVVKVYLQDVKVLTLLLESNSAKDLACL
       :.:::.: :... ::.:....:.:.  : :..  :.... ::: .:::.::..: .::::
NP_055 SHVINTKTNLVALLADFSHVNRIEMFSEEESLVRVELHVLDVKPITLLMESSDAMNLACL
       450       460       470       480       490       500       

          490       500       510       520       530       540    
pF1KSD IAGYYRLLVDPVTSIFLWPGNKQQAHRVSAEEGYESRACSDSEESSEVDCVLEPLS----
        :::::::::   :::   ..:. :   . : : :... . .  . . .:. .  .    
NP_055 TAGYYRLLVDSRRSIFNMANKKNTA---TQETGPENKG-KHNLLGPDWNCIPQMTTFIGE
       510       520       530          540        550       560   

              550       560       570            580       590     
pF1KSD DRRLVKLAPCRSLIKEEQPPGNSPTPEVARR-----GPSTCGASSTTDSAESEASDSANT
        .. ....   :  :  .   ..  :.  :.     . :. : ..   :  .::   :. 
NP_055 GEQEAQITYIDSKQKTVEITDSTMCPKEHRHLYIDNAYSSDGLNQQL-SQPGEAPCEADY
           570       580       590       600       610        620  

         600       610       620       630       640       650     
pF1KSD ESRGYRTSGSSESMDALEEDDLDTCSSSRSTFFHFGSPGLAESIDSDSQEERSGIETSGF
       .: . :.  .  . ..:.. . ..  ... .:. ::. .: ..:.           : :.
NP_055 RSLAQRSLLTLSGPETLKKAQ-ESPRGAKVSFI-FGDFALDDGISPP---------TLGY
            630       640        650        660                670 

         660       670       680       690                 700     
pF1KSD LCLLDLAQRANPQCQKTEFSESAALETFGWAPELSTVRL----------DPRLYEGSHAD
         ::: . .   . ..  .. .  .. .  .::   ...          : . ...... 
NP_055 ETLLDEGPEMLEKQRNLYIGSANDMKGLDLTPEAEGIQFVENSVYANIGDVKSFQAAEGI
             680       690       700       710       720       730 

         710       720         730       740         750       760 
pF1KSD YYSLCSSVSPASYLSDSSES--TASRQGGAPPAWGQQGWTEAQPSS--MLEPLALHPPLA
          :  ..  :   .:. .   .. ..  .    .: .  . . ::  ...  .: ::  
NP_055 EEPLLHDICYAENTDDAEDEDEVSCEEDLVVGEMNQPAILNLSGSSDDIIDLTSLPPP--
             740       750       760       770       780           

             770       780       790                    800        
pF1KSD FEDGSSDEEYYDAADKLTPPGPPSGPRDVSTAEPS-------------ATSLQNKASTSS
        :  ......   . ...  .:: : :: :  : :             ..::::     :
NP_055 -EGDDNEDDFLLRSLNMAIAAPPPGFRDSSDEEDSQSQAASFPEDKEKGSSLQNDEIPVS
      790       800       810       820       830       840        

      810       820       830       840            850         860 
pF1KSD PENSLPCGPDGRQPSRRGGVKKYAKTLRKRRSF-----LQTDYTSQVSF--PLVPSASLE
         ...: . .:.   ..:  .  ..::   ...      ::. .: :..     : .: .
NP_055 LIDAVPTSAEGK--CEKGLDNAVVSTLGALEALSVSEEQQTSDNSGVAILRAYSPESSSD
      850       860         870       880       890       900      

             870       880       890       900       910       920 
pF1KSD SVDDVCYYDREPYLALGAPSPTVSSLQDMQGEPGLLETKALGLLAPLRETKSTNPASRV-
       : ...   .      :.. .    .:. :     .: :.  :   :: : ..  :::.. 
NP_055 SGNETNSSEMTESSELATAQKQSENLSRM-----FLATHE-GY-HPLAEEQTEFPASKTP
        910       920       930            940         950         

                         930       940       950       960         
pF1KSD -----------MEMEPETMETKSVIDSRVSSISAIRFRIDPNNKENSGVVPAASSSASTP
                  .  .: :    .:. :. . . . .....:.. :...:    ..  :  
NP_055 AGGLPPKSSHALAARPATDLPPKVVPSK-QLLHSDHMEMEPETMETKSV----TDYFSKL
     960       970       980        990      1000          1010    

     970       980       990      1000      1010      1020         
pF1KSD HCSNPGSSGPDTAQARPSQILPLSQDLDGIAPKEPTIEHGDSSFSLSSGDPNPDRACLAS
       :    :: . . .. : :..     : .: ::  :   .:... . ..:  . .    ::
NP_055 HM---GSVAYSCTSKRKSKL----ADGEGKAP--P---NGNTTGKKQQGTKTAEMEEEAS
            1020      1030            1040         1050      1060  

    1030      1040         1050      1060      1070      1080      
pF1KSD NPGLNNVSQGDTLELQ---LEPHVQLEMGLESFCTNHIQETAPKYTEPLLSPRDEPRSDE
       .  ...::. :. .:.   :: .. ..   . . .      : :      . .  ::.. 
NP_055 GK-FGTVSSRDSQHLSTFNLE-RTAFRKDSQRWYVATEGGMAEKSGLEAATGKTFPRASG
            1070      1080       1090      1100      1110      1120

       1090       1100      1110      1120      1130      1140     
pF1KSD CGINPGE-KIASIPTKEEPQGQLSLERDREVTNKNGTNVFQEESRKDSGDSPGDVSNNVS
        :   .: :  . :  :  .:.   . :: .:.     :    : ::  :.: :..... 
NP_055 LGAREAEGKEEGAPDGETSDGSGLGQGDRFLTD-----VTCASSAKDL-DNPEDADSSTC
             1130      1140      1150           1160       1170    

        1150      1160         1170       1180       1190      1200
pF1KSD QTLDISSPAGKIVTSLSLD---APVTGTEQIPPHPP-RDPQGQSREPP-GQGCQAQEQKL
       .  .    : . :. :  :   :   .. :   :   .. ::.: .   : : ...    
NP_055 DHPSKLPEADESVARLC-DYHLAKRMSSLQSEGHFSLQSSQGSSVDAGCGTGSSGSACAT
         1180      1190       1200      1210      1220      1230   

             1210      1220             1230       1240      1250  
pF1KSD FVELDLDPDFFLGKQTVSPA-------VPPEGIKAEAPNH-VTGQDIAPRDSPEWVCFNP
        ::  : :.  :::. .  :       .: :      ::: .: ... :.   : .:  :
NP_055 PVESPLCPS--LGKHLIPDASGKGVNYIPSEERAPGLPNHGATFKELHPQ--TEGMC--P
          1240        1250      1260      1270      1280           

           1260      1270      1280      1290      1300      1310  
pF1KSD EPSLPEPLPCPQEDPHLETSNHCLLLEGKSDSSSICLSAEKSFLCFAPESHPEVSASLRV
       . ..:                                                       
NP_055 RMTVPALHTAINTEPLFGTLRDGCHRLPKIKETTV                         
      1290      1300      1310      1320                           




1578 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 04:28:51 2016 done: Thu Nov  3 04:28:53 2016
 Total Scan time: 17.220 Total Display time:  0.930

Function used was FASTA [36.3.4 Apr, 2011]
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