Result of FASTA (omim) for pF1KSDA0638
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KSDA0638, 1377 aa
  1>>>pF1KSDA0638 1377 - 1377 aa - 1377 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 15.9133+/-0.000459; mu= -27.0459+/- 0.028
 mean_var=557.9679+/-115.524, 0's: 0 Z-trim(123.1): 61  B-trim: 631 in 1/57
 Lambda= 0.054296
 statistics sampled from 42354 (42416) to 42354 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.767), E-opt: 0.2 (0.497), width:  16
 Scan time: 15.170

The best scores are:                                      opt bits E(85289)
NP_001138230 (OMIM: 612834) pleckstrin homology-li (1377) 9054 725.0  9e-208
NP_055972 (OMIM: 612834) pleckstrin homology-like  (1377) 9054 725.0  9e-208
XP_005271527 (OMIM: 612834) PREDICTED: pleckstrin  (1423) 9054 725.0 9.2e-208
XP_005271528 (OMIM: 612834) PREDICTED: pleckstrin  (1412) 8666 694.6 1.3e-198
XP_006718865 (OMIM: 612834) PREDICTED: pleckstrin  (1419) 8053 646.6 3.7e-184
XP_006718866 (OMIM: 612834) PREDICTED: pleckstrin  (1408) 7665 616.2 5.2e-175
XP_005271526 (OMIM: 612834) PREDICTED: pleckstrin  (1427) 7097 571.7 1.3e-161
XP_005271525 (OMIM: 612834) PREDICTED: pleckstrin  (1438) 6833 551.1 2.2e-155
XP_011541009 (OMIM: 612834) PREDICTED: pleckstrin  (1543) 6080 492.1 1.3e-137
XP_016872896 (OMIM: 612834) PREDICTED: pleckstrin  (1542) 6063 490.8 3.3e-137
XP_005271529 (OMIM: 612834) PREDICTED: pleckstrin  (1391) 6014 486.9 4.4e-136
NP_001138231 (OMIM: 612834) pleckstrin homology-li (1319) 5996 485.5 1.1e-135
XP_005271531 (OMIM: 612834) PREDICTED: pleckstrin  (1365) 5996 485.5 1.1e-135
XP_005271530 (OMIM: 612834) PREDICTED: pleckstrin  (1376) 5996 485.5 1.2e-135
XP_016872899 (OMIM: 612834) PREDICTED: pleckstrin  (1495) 5987 484.8  2e-135
XP_006718864 (OMIM: 612834) PREDICTED: pleckstrin  (1434) 5862 475.0 1.7e-132
XP_006718860 (OMIM: 612834) PREDICTED: pleckstrin  (1538) 5365 436.1 9.6e-121
XP_016872897 (OMIM: 612834) PREDICTED: pleckstrin  (1512) 5358 435.5 1.4e-120
XP_011541010 (OMIM: 612834) PREDICTED: pleckstrin  (1540) 5334 433.7 5.2e-120
XP_011541011 (OMIM: 612834) PREDICTED: pleckstrin  (1540) 5334 433.7 5.2e-120
XP_011541008 (OMIM: 612834) PREDICTED: pleckstrin  (1560) 5334 433.7 5.2e-120
XP_011541007 (OMIM: 612834) PREDICTED: pleckstrin  (1571) 5334 433.7 5.3e-120
XP_011541006 (OMIM: 612834) PREDICTED: pleckstrin  (1575) 5334 433.7 5.3e-120
XP_011541005 (OMIM: 612834) PREDICTED: pleckstrin  (1586) 5334 433.7 5.3e-120
XP_016872898 (OMIM: 612834) PREDICTED: pleckstrin  (1503) 5328 433.2  7e-120
XP_011541012 (OMIM: 612834) PREDICTED: pleckstrin  (1529) 5328 433.2 7.1e-120
XP_006718863 (OMIM: 612834) PREDICTED: pleckstrin  (1455) 5321 432.6  1e-119
XP_006718862 (OMIM: 612834) PREDICTED: pleckstrin  (1466) 5321 432.6  1e-119
XP_006718861 (OMIM: 612834) PREDICTED: pleckstrin  (1481) 5321 432.6  1e-119
XP_006718859 (OMIM: 612834) PREDICTED: pleckstrin  (1539) 5317 432.3 1.3e-119
XP_005277737 (OMIM: 612834) PREDICTED: pleckstrin  (1585) 5317 432.3 1.3e-119
XP_011541016 (OMIM: 612834) PREDICTED: pleckstrin  ( 848) 5269 428.4 1.1e-118
XP_016872900 (OMIM: 612834) PREDICTED: pleckstrin  ( 858) 5263 428.0 1.5e-118
XP_005271532 (OMIM: 612834) PREDICTED: pleckstrin  ( 858) 5263 428.0 1.5e-118
XP_011541013 (OMIM: 612834) PREDICTED: pleckstrin  (1420) 4522 370.0 6.8e-101
XP_011541015 (OMIM: 612834) PREDICTED: pleckstrin  (1419) 4505 368.7 1.7e-100
XP_011541017 (OMIM: 612834) PREDICTED: pleckstrin  ( 721) 2446 207.3 3.4e-52
NP_665696 (OMIM: 610298) pleckstrin homology-like  (1210) 1322 119.3 1.7e-25
NP_001127909 (OMIM: 610298) pleckstrin homology-li (1237) 1322 119.3 1.7e-25
NP_001127911 (OMIM: 610298) pleckstrin homology-li (1253) 1144 105.4 2.8e-21
NP_001127910 (OMIM: 610298) pleckstrin homology-li (1253) 1144 105.4 2.8e-21


>>NP_001138230 (OMIM: 612834) pleckstrin homology-like d  (1377 aa)
 initn: 9054 init1: 9054 opt: 9054  Z-score: 3851.2  bits: 725.0 E(85289): 9e-208
Smith-Waterman score: 9054; 100.0% identity (100.0% similar) in 1377 aa overlap (1-1377:1-1377)

               10        20        30        40        50        60
pF1KSD MDALNRNQIGPGCQTQTMVQKGPLDLIETGKGLKVQTDKPHLVSLGSGRLSTAITLLPLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDALNRNQIGPGCQTQTMVQKGPLDLIETGKGLKVQTDKPHLVSLGSGRLSTAITLLPLE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD EGRTVIGSAARDISLQGPGLAPEHCYIENLRGTLTLYPCGNACTIDGLPVRQPTRLTQGC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGRTVIGSAARDISLQGPGLAPEHCYIENLRGTLTLYPCGNACTIDGLPVRQPTRLTQGC
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD MLCLGQSTFLRFNHPAEAKWMKSMIPAGGRAPGPPYSPVPAESESLVNGNHTPQTATRGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLCLGQSTFLRFNHPAEAKWMKSMIPAGGRAPGPPYSPVPAESESLVNGNHTPQTATRGP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD SACASHSSLVSSIEKDLQEIMDSLVLEEPGAAGKKPAATSPLSPMANGGRYLLSPPTSPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SACASHSSLVSSIEKDLQEIMDSLVLEEPGAAGKKPAATSPLSPMANGGRYLLSPPTSPG
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD AMSVGSSYENTSPAFSPLSSPASSGSCASHSPSGQEPGPSVPPLVPARSSSYHLALQPPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AMSVGSSYENTSPAFSPLSSPASSGSCASHSPSGQEPGPSVPPLVPARSSSYHLALQPPQ
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD SRPSGARSESPRLSRKGGHERPPSPGLRGLLTDSPAATVLAEARRATESPRLGGQLPVVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRPSGARSESPRLSRKGGHERPPSPGLRGLLTDSPAATVLAEARRATESPRLGGQLPVVA
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD ISLSEYPASGALSQPTSIPGSPKFQPPVPAPRNKIGTLQDRPPSPFREPPGSERVLTTSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISLSEYPASGALSQPTSIPGSPKFQPPVPAPRNKIGTLQDRPPSPFREPPGSERVLTTSP
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD SRQLVGRTFSDGLATRTLQPPESPRLGRRGLDSMRELPPLSPSLSRRALSPLPTRTTPDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRQLVGRTFSDGLATRTLQPPESPRLGRRGLDSMRELPPLSPSLSRRALSPLPTRTTPDP
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KSD KLNREVAESPRPRRWAAHGASPEDFSLTLGARGRRTRSPSPTLGESLAPHKGSFSGRLSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLNREVAESPRPRRWAAHGASPEDFSLTLGARGRRTRSPSPTLGESLAPHKGSFSGRLSP
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KSD AYSLGSLTGASPCQSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AYSLGSLTGASPCQSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQER
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KSD LREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAGA
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KSD SGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEER
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KSD AQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKL
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KSD VALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRS
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KSD IAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGG
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KSD RPFPKTTSTLKEMEKLLLPAVDLEQWYQELMAGLGTGPAAASPHSSPPPLPAKASRQLQV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RPFPKTTSTLKEMEKLLLPAVDLEQWYQELMAGLGTGPAAASPHSSPPPLPAKASRQLQV
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KSD YRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPR
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KSD NLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGP
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KSD SGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSA
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KSD SGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESAR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESAR
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KSD RQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCR
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KSD GYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAK
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370       
pF1KSD KRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
             1330      1340      1350      1360      1370       

>>NP_055972 (OMIM: 612834) pleckstrin homology-like doma  (1377 aa)
 initn: 9054 init1: 9054 opt: 9054  Z-score: 3851.2  bits: 725.0 E(85289): 9e-208
Smith-Waterman score: 9054; 100.0% identity (100.0% similar) in 1377 aa overlap (1-1377:1-1377)

               10        20        30        40        50        60
pF1KSD MDALNRNQIGPGCQTQTMVQKGPLDLIETGKGLKVQTDKPHLVSLGSGRLSTAITLLPLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MDALNRNQIGPGCQTQTMVQKGPLDLIETGKGLKVQTDKPHLVSLGSGRLSTAITLLPLE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD EGRTVIGSAARDISLQGPGLAPEHCYIENLRGTLTLYPCGNACTIDGLPVRQPTRLTQGC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 EGRTVIGSAARDISLQGPGLAPEHCYIENLRGTLTLYPCGNACTIDGLPVRQPTRLTQGC
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD MLCLGQSTFLRFNHPAEAKWMKSMIPAGGRAPGPPYSPVPAESESLVNGNHTPQTATRGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MLCLGQSTFLRFNHPAEAKWMKSMIPAGGRAPGPPYSPVPAESESLVNGNHTPQTATRGP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD SACASHSSLVSSIEKDLQEIMDSLVLEEPGAAGKKPAATSPLSPMANGGRYLLSPPTSPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SACASHSSLVSSIEKDLQEIMDSLVLEEPGAAGKKPAATSPLSPMANGGRYLLSPPTSPG
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD AMSVGSSYENTSPAFSPLSSPASSGSCASHSPSGQEPGPSVPPLVPARSSSYHLALQPPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 AMSVGSSYENTSPAFSPLSSPASSGSCASHSPSGQEPGPSVPPLVPARSSSYHLALQPPQ
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD SRPSGARSESPRLSRKGGHERPPSPGLRGLLTDSPAATVLAEARRATESPRLGGQLPVVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SRPSGARSESPRLSRKGGHERPPSPGLRGLLTDSPAATVLAEARRATESPRLGGQLPVVA
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD ISLSEYPASGALSQPTSIPGSPKFQPPVPAPRNKIGTLQDRPPSPFREPPGSERVLTTSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 ISLSEYPASGALSQPTSIPGSPKFQPPVPAPRNKIGTLQDRPPSPFREPPGSERVLTTSP
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD SRQLVGRTFSDGLATRTLQPPESPRLGRRGLDSMRELPPLSPSLSRRALSPLPTRTTPDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SRQLVGRTFSDGLATRTLQPPESPRLGRRGLDSMRELPPLSPSLSRRALSPLPTRTTPDP
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KSD KLNREVAESPRPRRWAAHGASPEDFSLTLGARGRRTRSPSPTLGESLAPHKGSFSGRLSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KLNREVAESPRPRRWAAHGASPEDFSLTLGARGRRTRSPSPTLGESLAPHKGSFSGRLSP
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KSD AYSLGSLTGASPCQSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 AYSLGSLTGASPCQSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQER
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KSD LREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAGA
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KSD SGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEER
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KSD AQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 AQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKL
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KSD VALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 VALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRS
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KSD IAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 IAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGG
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KSD RPFPKTTSTLKEMEKLLLPAVDLEQWYQELMAGLGTGPAAASPHSSPPPLPAKASRQLQV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 RPFPKTTSTLKEMEKLLLPAVDLEQWYQELMAGLGTGPAAASPHSSPPPLPAKASRQLQV
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KSD YRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 YRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPR
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KSD NLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 NLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGP
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KSD SGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSA
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KSD SGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESAR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESAR
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KSD RQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 RQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCR
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KSD GYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAK
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370       
pF1KSD KRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
             1330      1340      1350      1360      1370       

>>XP_005271527 (OMIM: 612834) PREDICTED: pleckstrin homo  (1423 aa)
 initn: 9054 init1: 9054 opt: 9054  Z-score: 3851.0  bits: 725.0 E(85289): 9.2e-208
Smith-Waterman score: 9054; 100.0% identity (100.0% similar) in 1377 aa overlap (1-1377:47-1423)

                                             10        20        30
pF1KSD                               MDALNRNQIGPGCQTQTMVQKGPLDLIETG
                                     ::::::::::::::::::::::::::::::
XP_005 PGGPLATAMHRLGRGRGRPPGTQELWSLRTMDALNRNQIGPGCQTQTMVQKGPLDLIETG
         20        30        40        50        60        70      

               40        50        60        70        80        90
pF1KSD KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
         80        90       100       110       120       130      

              100       110       120       130       140       150
pF1KSD RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
        140       150       160       170       180       190      

              160       170       180       190       200       210
pF1KSD APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
        200       210       220       230       240       250      

              220       230       240       250       260       270
pF1KSD AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
        260       270       280       290       300       310      

              280       290       300       310       320       330
pF1KSD SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
        320       330       340       350       360       370      

              340       350       360       370       380       390
pF1KSD LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
        380       390       400       410       420       430      

              400       410       420       430       440       450
pF1KSD PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
        440       450       460       470       480       490      

              460       470       480       490       500       510
pF1KSD LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
        500       510       520       530       540       550      

              520       530       540       550       560       570
pF1KSD ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
        560       570       580       590       600       610      

              580       590       600       610       620       630
pF1KSD VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
        620       630       640       650       660       670      

              640       650       660       670       680       690
pF1KSD PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
        680       690       700       710       720       730      

              700       710       720       730       740       750
pF1KSD CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
        740       750       760       770       780       790      

              760       770       780       790       800       810
pF1KSD ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
        800       810       820       830       840       850      

              820       830       840       850       860       870
pF1KSD QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
        860       870       880       890       900       910      

              880       890       900       910       920       930
pF1KSD RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEMEKLLLPAVDLEQWYQEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEMEKLLLPAVDLEQWYQEL
        920       930       940       950       960       970      

              940       950       960       970       980       990
pF1KSD MAGLGTGPAAASPHSSPPPLPAKASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MAGLGTGPAAASPHSSPPPLPAKASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSS
        980       990      1000      1010      1020      1030      

             1000      1010      1020      1030      1040      1050
pF1KSD SSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRR
       1040      1050      1060      1070      1080      1090      

             1060      1070      1080      1090      1100      1110
pF1KSD RLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYD
       1100      1110      1120      1130      1140      1150      

             1120      1130      1140      1150      1160      1170
pF1KSD TLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESRE
       1160      1170      1180      1190      1200      1210      

             1180      1190      1200      1210      1220      1230
pF1KSD REMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 REMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRK
       1220      1230      1240      1250      1260      1270      

             1240      1250      1260      1270      1280      1290
pF1KSD EDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYY
       1280      1290      1300      1310      1320      1330      

             1300      1310      1320      1330      1340      1350
pF1KSD VDKHETKLKGVIYFQAIEEVYYDHLRSAAKKRFFRFTMVTESPNPALTFCVKTHDRLYYM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VDKHETKLKGVIYFQAIEEVYYDHLRSAAKKRFFRFTMVTESPNPALTFCVKTHDRLYYM
       1340      1350      1360      1370      1380      1390      

             1360      1370       
pF1KSD VAPSAEAMRIWMDVIVTGAEGYTQFMN
       :::::::::::::::::::::::::::
XP_005 VAPSAEAMRIWMDVIVTGAEGYTQFMN
       1400      1410      1420   

>>XP_005271528 (OMIM: 612834) PREDICTED: pleckstrin homo  (1412 aa)
 initn: 8666 init1: 8666 opt: 8666  Z-score: 3686.8  bits: 694.6 E(85289): 1.3e-198
Smith-Waterman score: 8950; 99.2% identity (99.2% similar) in 1377 aa overlap (1-1377:47-1412)

                                             10        20        30
pF1KSD                               MDALNRNQIGPGCQTQTMVQKGPLDLIETG
                                     ::::::::::::::::::::::::::::::
XP_005 PGGPLATAMHRLGRGRGRPPGTQELWSLRTMDALNRNQIGPGCQTQTMVQKGPLDLIETG
         20        30        40        50        60        70      

               40        50        60        70        80        90
pF1KSD KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
         80        90       100       110       120       130      

              100       110       120       130       140       150
pF1KSD RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
        140       150       160       170       180       190      

              160       170       180       190       200       210
pF1KSD APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
        200       210       220       230       240       250      

              220       230       240       250       260       270
pF1KSD AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
        260       270       280       290       300       310      

              280       290       300       310       320       330
pF1KSD SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
        320       330       340       350       360       370      

              340       350       360       370       380       390
pF1KSD LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
        380       390       400       410       420       430      

              400       410       420       430       440       450
pF1KSD PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
        440       450       460       470       480       490      

              460       470       480       490       500       510
pF1KSD LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
        500       510       520       530       540       550      

              520       530       540       550       560       570
pF1KSD ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
        560       570       580       590       600       610      

              580       590       600       610       620       630
pF1KSD VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
        620       630       640       650       660       670      

              640       650       660       670       680       690
pF1KSD PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
        680       690       700       710       720       730      

              700       710       720       730       740       750
pF1KSD CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
        740       750       760       770       780       790      

              760       770       780       790       800       810
pF1KSD ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
        800       810       820       830       840       850      

              820       830       840       850       860       870
pF1KSD QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
        860       870       880       890       900       910      

              880       890       900       910       920       930
pF1KSD RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEMEKLLLPAVDLEQWYQEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEMEKLLLPAVDLEQWYQEL
        920       930       940       950       960       970      

              940       950       960       970       980       990
pF1KSD MAGLGTGPAAASPHSSPPPLPAKASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MAGLGTGPAAASPHSSPPPLPAKASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSS
        980       990      1000      1010      1020      1030      

             1000      1010      1020      1030      1040      1050
pF1KSD SSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRR
       1040      1050      1060      1070      1080      1090      

             1060      1070      1080      1090      1100      1110
pF1KSD RLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYD
       1100      1110      1120      1130      1140      1150      

             1120      1130      1140      1150      1160      1170
pF1KSD TLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESRE
       1160      1170      1180      1190      1200      1210      

             1180      1190      1200      1210      1220      1230
pF1KSD REMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 REMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRK
       1220      1230      1240      1250      1260      1270      

             1240      1250      1260      1270      1280      1290
pF1KSD EDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYY
       1280      1290      1300      1310      1320      1330      

             1300      1310      1320      1330      1340      1350
pF1KSD VDKHETKLKGVIYFQAIEEVYYDHLRSAAKKRFFRFTMVTESPNPALTFCVKTHDRLYYM
       ::::::::::::::::::::::::::::::           :::::::::::::::::::
XP_005 VDKHETKLKGVIYFQAIEEVYYDHLRSAAK-----------SPNPALTFCVKTHDRLYYM
       1340      1350      1360                 1370      1380     

             1360      1370       
pF1KSD VAPSAEAMRIWMDVIVTGAEGYTQFMN
       :::::::::::::::::::::::::::
XP_005 VAPSAEAMRIWMDVIVTGAEGYTQFMN
        1390      1400      1410  

>>XP_006718865 (OMIM: 612834) PREDICTED: pleckstrin homo  (1419 aa)
 initn: 8010 init1: 5272 opt: 8053  Z-score: 3427.2  bits: 646.6 E(85289): 3.7e-184
Smith-Waterman score: 8535; 93.7% identity (93.7% similar) in 1420 aa overlap (1-1377:47-1419)

                                             10        20        30
pF1KSD                               MDALNRNQIGPGCQTQTMVQKGPLDLIETG
                                     ::::::::::::::::::::::::::::::
XP_006 PGGPLATAMHRLGRGRGRPPGTQELWSLRTMDALNRNQIGPGCQTQTMVQKGPLDLIETG
         20        30        40        50        60        70      

               40        50        60        70        80        90
pF1KSD KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
         80        90       100       110       120       130      

              100       110       120       130       140       150
pF1KSD RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
        140       150       160       170       180       190      

              160       170       180       190       200       210
pF1KSD APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
        200       210       220       230       240       250      

              220       230       240       250       260       270
pF1KSD AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
        260       270       280       290       300       310      

              280       290       300       310       320       330
pF1KSD SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
        320       330       340       350       360       370      

              340       350       360       370       380       390
pF1KSD LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
        380       390       400       410       420       430      

              400       410       420       430       440       450
pF1KSD PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
        440       450       460       470       480       490      

              460       470       480       490       500       510
pF1KSD LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
        500       510       520       530       540       550      

              520       530       540       550       560       570
pF1KSD ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
        560       570       580       590       600       610      

              580       590       600       610       620       630
pF1KSD VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
        620       630       640       650       660       670      

              640       650       660       670       680       690
pF1KSD PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
        680       690       700       710       720       730      

              700       710       720       730       740       750
pF1KSD CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
        740       750       760       770       780       790      

              760       770       780       790                    
pF1KSD ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKE----------------
       ::::::::::::::::::::::::::::::::::::::::::::                
XP_006 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKERAELAAGRRHLEARQA
        800       810       820       830       840       850      

                                     800       810       820       
pF1KSD ---------------------------AEALETETKLFEDLEFQQLERESRVEEERELAG
                                  :::::::::::::::::::::::::::::::::
XP_006 LYAELQTQLDNCPESVREQLQEQLRREAEALETETKLFEDLEFQQLERESRVEEERELAG
        860       870       880       890       900       910      

       830       840       850       860       870       880       
pF1KSD QGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKL
        920       930       940       950       960       970      

       890       900       910       920       930       940       
pF1KSD TVLERRYHSLTGGRPFPKTTSTLKEMEKLLLPAVDLEQWYQELMAGLGTGPAAASPHSSP
       :::::::::::::::::::::::::                                   
XP_006 TVLERRYHSLTGGRPFPKTTSTLKE-----------------------------------
        980       990      1000                                    

       950       960       970       980       990      1000       
pF1KSD PPLPAKASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKS
                   ::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ------------VYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKS
                        1010      1020      1030      1040         

      1010      1020      1030      1040      1050      1060       
pF1KSD ALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQW
    1050      1060      1070      1080      1090      1100         

      1070      1080      1090      1100      1110      1120       
pF1KSD DALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTG
    1110      1120      1130      1140      1150      1160         

      1130      1140      1150      1160      1170      1180       
pF1KSD GNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRR
    1170      1180      1190      1200      1210      1220         

      1190      1200      1210      1220      1230      1240       
pF1KSD EQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVD
    1230      1240      1250      1260      1270      1280         

      1250      1260      1270      1280      1290      1300       
pF1KSD TCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAI
    1290      1300      1310      1320      1330      1340         

      1310      1320      1330      1340      1350      1360       
pF1KSD EEVYYDHLRSAAKKRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EEVYYDHLRSAAKKRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVT
    1350      1360      1370      1380      1390      1400         

      1370       
pF1KSD GAEGYTQFMN
       ::::::::::
XP_006 GAEGYTQFMN
    1410         

>>XP_006718866 (OMIM: 612834) PREDICTED: pleckstrin homo  (1408 aa)
 initn: 7622 init1: 5272 opt: 7665  Z-score: 3263.0  bits: 616.2 E(85289): 5.2e-175
Smith-Waterman score: 8431; 92.9% identity (92.9% similar) in 1420 aa overlap (1-1377:47-1408)

                                             10        20        30
pF1KSD                               MDALNRNQIGPGCQTQTMVQKGPLDLIETG
                                     ::::::::::::::::::::::::::::::
XP_006 PGGPLATAMHRLGRGRGRPPGTQELWSLRTMDALNRNQIGPGCQTQTMVQKGPLDLIETG
         20        30        40        50        60        70      

               40        50        60        70        80        90
pF1KSD KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
         80        90       100       110       120       130      

              100       110       120       130       140       150
pF1KSD RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
        140       150       160       170       180       190      

              160       170       180       190       200       210
pF1KSD APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
        200       210       220       230       240       250      

              220       230       240       250       260       270
pF1KSD AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
        260       270       280       290       300       310      

              280       290       300       310       320       330
pF1KSD SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
        320       330       340       350       360       370      

              340       350       360       370       380       390
pF1KSD LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
        380       390       400       410       420       430      

              400       410       420       430       440       450
pF1KSD PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
        440       450       460       470       480       490      

              460       470       480       490       500       510
pF1KSD LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
        500       510       520       530       540       550      

              520       530       540       550       560       570
pF1KSD ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
        560       570       580       590       600       610      

              580       590       600       610       620       630
pF1KSD VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
        620       630       640       650       660       670      

              640       650       660       670       680       690
pF1KSD PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
        680       690       700       710       720       730      

              700       710       720       730       740       750
pF1KSD CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
        740       750       760       770       780       790      

              760       770       780       790                    
pF1KSD ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKE----------------
       ::::::::::::::::::::::::::::::::::::::::::::                
XP_006 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKERAELAAGRRHLEARQA
        800       810       820       830       840       850      

                                     800       810       820       
pF1KSD ---------------------------AEALETETKLFEDLEFQQLERESRVEEERELAG
                                  :::::::::::::::::::::::::::::::::
XP_006 LYAELQTQLDNCPESVREQLQEQLRREAEALETETKLFEDLEFQQLERESRVEEERELAG
        860       870       880       890       900       910      

       830       840       850       860       870       880       
pF1KSD QGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKL
        920       930       940       950       960       970      

       890       900       910       920       930       940       
pF1KSD TVLERRYHSLTGGRPFPKTTSTLKEMEKLLLPAVDLEQWYQELMAGLGTGPAAASPHSSP
       :::::::::::::::::::::::::                                   
XP_006 TVLERRYHSLTGGRPFPKTTSTLKE-----------------------------------
        980       990      1000                                    

       950       960       970       980       990      1000       
pF1KSD PPLPAKASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKS
                   ::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ------------VYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKS
                        1010      1020      1030      1040         

      1010      1020      1030      1040      1050      1060       
pF1KSD ALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQW
    1050      1060      1070      1080      1090      1100         

      1070      1080      1090      1100      1110      1120       
pF1KSD DALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTG
    1110      1120      1130      1140      1150      1160         

      1130      1140      1150      1160      1170      1180       
pF1KSD GNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRR
    1170      1180      1190      1200      1210      1220         

      1190      1200      1210      1220      1230      1240       
pF1KSD EQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVD
    1230      1240      1250      1260      1270      1280         

      1250      1260      1270      1280      1290      1300       
pF1KSD TCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAI
    1290      1300      1310      1320      1330      1340         

      1310      1320      1330      1340      1350      1360       
pF1KSD EEVYYDHLRSAAKKRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVT
       :::::::::::::           ::::::::::::::::::::::::::::::::::::
XP_006 EEVYYDHLRSAAK-----------SPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVT
    1350      1360                 1370      1380      1390        

      1370       
pF1KSD GAEGYTQFMN
       ::::::::::
XP_006 GAEGYTQFMN
     1400        

>>XP_005271526 (OMIM: 612834) PREDICTED: pleckstrin homo  (1427 aa)
 initn: 7111 init1: 6808 opt: 7097  Z-score: 3022.5  bits: 571.7 E(85289): 1.3e-161
Smith-Waterman score: 8910; 98.1% identity (98.1% similar) in 1392 aa overlap (1-1377:47-1427)

                                             10        20        30
pF1KSD                               MDALNRNQIGPGCQTQTMVQKGPLDLIETG
                                     ::::::::::::::::::::::::::::::
XP_005 PGGPLATAMHRLGRGRGRPPGTQELWSLRTMDALNRNQIGPGCQTQTMVQKGPLDLIETG
         20        30        40        50        60        70      

               40        50        60        70        80        90
pF1KSD KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
         80        90       100       110       120       130      

              100       110       120       130       140       150
pF1KSD RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
        140       150       160       170       180       190      

              160       170       180       190       200       210
pF1KSD APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
        200       210       220       230       240       250      

              220       230       240       250       260       270
pF1KSD AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
        260       270       280       290       300       310      

              280       290       300       310       320       330
pF1KSD SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
        320       330       340       350       360       370      

              340       350       360       370       380       390
pF1KSD LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
        380       390       400       410       420       430      

              400       410       420       430       440       450
pF1KSD PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
        440       450       460       470       480       490      

              460       470       480       490       500       510
pF1KSD LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
        500       510       520       530       540       550      

              520       530       540       550       560       570
pF1KSD ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
        560       570       580       590       600       610      

              580       590       600       610       620       630
pF1KSD VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
        620       630       640       650       660       670      

              640       650       660       670       680       690
pF1KSD PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
        680       690       700       710       720       730      

              700       710       720       730       740       750
pF1KSD CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
        740       750       760       770       780       790      

              760       770       780       790       800       810
pF1KSD ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
        800       810       820       830       840       850      

              820       830       840       850       860       870
pF1KSD QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
        860       870       880       890       900       910      

              880       890       900       910       920       930
pF1KSD RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEMEKLLLPAVDLEQWYQEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEMEKLLLPAVDLEQWYQEL
        920       930       940       950       960       970      

              940       950       960       970       980       990
pF1KSD MAGLGTGPAAASPHSSPPPLPAKASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MAGLGTGPAAASPHSSPPPLPAKASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSS
        980       990      1000      1010      1020      1030      

             1000      1010      1020      1030      1040          
pF1KSD SSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQK----------
       ::::::::::::::::::::::::::::::::::::::::::::::::::          
XP_005 SSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKVESLPAEPLP
       1040      1050      1060      1070      1080      1090      

                  1050      1060      1070      1080      1090     
pF1KSD -----GQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHL
            :::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TDDPAGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHL
       1100      1110      1120      1130      1140      1150      

        1100      1110      1120      1130      1140      1150     
pF1KSD PAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKML
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKML
       1160      1170      1180      1190      1200      1210      

        1160      1170      1180      1190      1200      1210     
pF1KSD KEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQ
       1220      1230      1240      1250      1260      1270      

        1220      1230      1240      1250      1260      1270     
pF1KSD FSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKK
       1280      1290      1300      1310      1320      1330      

        1280      1290      1300      1310      1320      1330     
pF1KSD RWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAKKRFFRFTMVTESPNP
       :::::::::::::::::::::::::::::::::::::::::::::           ::::
XP_005 RWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAK-----------SPNP
       1340      1350      1360      1370      1380                

        1340      1350      1360      1370       
pF1KSD ALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
       ::::::::::::::::::::::::::::::::::::::::::
XP_005 ALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
        1390      1400      1410      1420       

>>XP_005271525 (OMIM: 612834) PREDICTED: pleckstrin homo  (1438 aa)
 initn: 6808 init1: 6808 opt: 6833  Z-score: 2910.6  bits: 551.1 E(85289): 2.2e-155
Smith-Waterman score: 9014; 98.9% identity (98.9% similar) in 1392 aa overlap (1-1377:47-1438)

                                             10        20        30
pF1KSD                               MDALNRNQIGPGCQTQTMVQKGPLDLIETG
                                     ::::::::::::::::::::::::::::::
XP_005 PGGPLATAMHRLGRGRGRPPGTQELWSLRTMDALNRNQIGPGCQTQTMVQKGPLDLIETG
         20        30        40        50        60        70      

               40        50        60        70        80        90
pF1KSD KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
         80        90       100       110       120       130      

              100       110       120       130       140       150
pF1KSD RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
        140       150       160       170       180       190      

              160       170       180       190       200       210
pF1KSD APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
        200       210       220       230       240       250      

              220       230       240       250       260       270
pF1KSD AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
        260       270       280       290       300       310      

              280       290       300       310       320       330
pF1KSD SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
        320       330       340       350       360       370      

              340       350       360       370       380       390
pF1KSD LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
        380       390       400       410       420       430      

              400       410       420       430       440       450
pF1KSD PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
        440       450       460       470       480       490      

              460       470       480       490       500       510
pF1KSD LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
        500       510       520       530       540       550      

              520       530       540       550       560       570
pF1KSD ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
        560       570       580       590       600       610      

              580       590       600       610       620       630
pF1KSD VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
        620       630       640       650       660       670      

              640       650       660       670       680       690
pF1KSD PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
        680       690       700       710       720       730      

              700       710       720       730       740       750
pF1KSD CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
        740       750       760       770       780       790      

              760       770       780       790       800       810
pF1KSD ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
        800       810       820       830       840       850      

              820       830       840       850       860       870
pF1KSD QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
        860       870       880       890       900       910      

              880       890       900       910       920       930
pF1KSD RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEMEKLLLPAVDLEQWYQEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEMEKLLLPAVDLEQWYQEL
        920       930       940       950       960       970      

              940       950       960       970       980       990
pF1KSD MAGLGTGPAAASPHSSPPPLPAKASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MAGLGTGPAAASPHSSPPPLPAKASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSS
        980       990      1000      1010      1020      1030      

             1000      1010      1020      1030      1040          
pF1KSD SSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQK----------
       ::::::::::::::::::::::::::::::::::::::::::::::::::          
XP_005 SSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKVESLPAEPLP
       1040      1050      1060      1070      1080      1090      

                  1050      1060      1070      1080      1090     
pF1KSD -----GQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHL
            :::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TDDPAGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHL
       1100      1110      1120      1130      1140      1150      

        1100      1110      1120      1130      1140      1150     
pF1KSD PAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKML
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKML
       1160      1170      1180      1190      1200      1210      

        1160      1170      1180      1190      1200      1210     
pF1KSD KEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQ
       1220      1230      1240      1250      1260      1270      

        1220      1230      1240      1250      1260      1270     
pF1KSD FSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKK
       1280      1290      1300      1310      1320      1330      

        1280      1290      1300      1310      1320      1330     
pF1KSD RWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAKKRFFRFTMVTESPNP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAKKRFFRFTMVTESPNP
       1340      1350      1360      1370      1380      1390      

        1340      1350      1360      1370       
pF1KSD ALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
       ::::::::::::::::::::::::::::::::::::::::::
XP_005 ALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
       1400      1410      1420      1430        

>>XP_011541009 (OMIM: 612834) PREDICTED: pleckstrin homo  (1543 aa)
 initn: 6030 init1: 6030 opt: 6080  Z-score: 2591.4  bits: 492.1 E(85289): 1.3e-137
Smith-Waterman score: 8206; 91.5% identity (91.5% similar) in 1409 aa overlap (1-1289:47-1455)

                                             10        20        30
pF1KSD                               MDALNRNQIGPGCQTQTMVQKGPLDLIETG
                                     ::::::::::::::::::::::::::::::
XP_011 PGGPLATAMHRLGRGRGRPPGTQELWSLRTMDALNRNQIGPGCQTQTMVQKGPLDLIETG
         20        30        40        50        60        70      

               40        50        60        70        80        90
pF1KSD KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
         80        90       100       110       120       130      

              100       110       120       130       140       150
pF1KSD RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
        140       150       160       170       180       190      

              160       170       180       190       200       210
pF1KSD APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
        200       210       220       230       240       250      

              220       230       240       250       260       270
pF1KSD AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
        260       270       280       290       300       310      

              280       290       300       310       320       330
pF1KSD SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
        320       330       340       350       360       370      

              340       350       360       370       380       390
pF1KSD LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
        380       390       400       410       420       430      

              400       410       420       430       440       450
pF1KSD PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
        440       450       460       470       480       490      

              460       470       480       490       500       510
pF1KSD LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
        500       510       520       530       540       550      

              520       530       540       550       560       570
pF1KSD ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
        560       570       580       590       600       610      

              580       590       600       610       620       630
pF1KSD VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
        620       630       640       650       660       670      

              640       650       660       670       680       690
pF1KSD PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
        680       690       700       710       720       730      

              700       710       720       730       740       750
pF1KSD CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
        740       750       760       770       780       790      

              760       770       780       790       800       810
pF1KSD ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
        800       810       820       830       840       850      

              820       830       840       850       860       870
pF1KSD QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
        860       870       880       890       900       910      

              880       890       900       910                    
pF1KSD RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKE------------------
       ::::::::::::::::::::::::::::::::::::::::::                  
XP_011 RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEAELLISESSEMGLGTKAL
        920       930       940       950       960       970      

                                                                   
pF1KSD ------------------------------------------------------------
                                                                   
XP_011 GLFPGSSQAGASSVSLTPPASTLLCPKAQEYVMLEQLKVMRGTSPMPPAPVPGLSPWASA
        980       990      1000      1010      1020      1030      

                                       920       930       940     
pF1KSD ---------------------------MEKLLLPAVDLEQWYQELMAGLGTGPAAASPHS
                                  :::::::::::::::::::::::::::::::::
XP_011 SRDLVPTTCLPPMLPSSSFASITPSPKMEKLLLPAVDLEQWYQELMAGLGTGPAAASPHS
       1040      1050      1060      1070      1080      1090      

         950       960       970       980       990      1000     
pF1KSD SPPPLPAKASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPPPLPAKASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSP
       1100      1110      1120      1130      1140      1150      

        1010      1020      1030      1040                     1050
pF1KSD KSALLTQNGTGSLPRNLAATLQDIETKRQLALQQK---------------GQQVIEEQRR
       :::::::::::::::::::::::::::::::::::               ::::::::::
XP_011 KSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKVESLPAEPLPTDDPAGQQVIEEQRR
       1160      1170      1180      1190      1200      1210      

             1060      1070      1080      1090      1100      1110
pF1KSD RLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYD
       1220      1230      1240      1250      1260      1270      

             1120      1130      1140      1150      1160      1170
pF1KSD TLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESRE
       1280      1290      1300      1310      1320      1330      

             1180      1190      1200      1210      1220      1230
pF1KSD REMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 REMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRK
       1340      1350      1360      1370      1380      1390      

             1240      1250      1260      1270      1280      1290
pF1KSD EDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: 
XP_011 EDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYY
       1400      1410      1420      1430      1440      1450      

             1300      1310      1320      1330      1340      1350
pF1KSD VDKHETKLKGVIYFQAIEEVYYDHLRSAAKKRFFRFTMVTESPNPALTFCVKTHDRLYYM
                                                                   
XP_011 VDKHETKLKGVIYFQAIEEVYYDHLRSAAKKRFFRFTMVTESPNPALTFCVKTHDRLYYM
       1460      1470      1480      1490      1500      1510      

>--
 initn: 588 init1: 588 opt: 588  Z-score: 266.4  bits: 61.9 E(85289): 4.3e-08
Smith-Waterman score: 588; 100.0% identity (100.0% similar) in 88 aa overlap (1290-1377:1456-1543)

    1260      1270      1280      1290      1300      1310         
pF1KSD RGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAA
                                     ::::::::::::::::::::::::::::::
XP_011 RGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAA
        1430      1440      1450      1460      1470      1480     

    1320      1330      1340      1350      1360      1370       
pF1KSD KKRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KKRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
        1490      1500      1510      1520      1530      1540   

>>XP_016872896 (OMIM: 612834) PREDICTED: pleckstrin homo  (1542 aa)
 initn: 6011 init1: 4917 opt: 6063  Z-score: 2584.2  bits: 490.8 E(85289): 3.3e-137
Smith-Waterman score: 8189; 91.4% identity (91.4% similar) in 1409 aa overlap (1-1289:47-1454)

                                             10        20        30
pF1KSD                               MDALNRNQIGPGCQTQTMVQKGPLDLIETG
                                     ::::::::::::::::::::::::::::::
XP_016 PGGPLATAMHRLGRGRGRPPGTQELWSLRTMDALNRNQIGPGCQTQTMVQKGPLDLIETG
         20        30        40        50        60        70      

               40        50        60        70        80        90
pF1KSD KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
         80        90       100       110       120       130      

              100       110       120       130       140       150
pF1KSD RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
        140       150       160       170       180       190      

              160       170       180       190       200       210
pF1KSD APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
       :::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APGPPYSPVP-ESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
        200        210       220       230       240       250     

              220       230       240       250       260       270
pF1KSD AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
         260       270       280       290       300       310     

              280       290       300       310       320       330
pF1KSD SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
         320       330       340       350       360       370     

              340       350       360       370       380       390
pF1KSD LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
         380       390       400       410       420       430     

              400       410       420       430       440       450
pF1KSD PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
         440       450       460       470       480       490     

              460       470       480       490       500       510
pF1KSD LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
         500       510       520       530       540       550     

              520       530       540       550       560       570
pF1KSD ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
         560       570       580       590       600       610     

              580       590       600       610       620       630
pF1KSD VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
         620       630       640       650       660       670     

              640       650       660       670       680       690
pF1KSD PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
         680       690       700       710       720       730     

              700       710       720       730       740       750
pF1KSD CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
         740       750       760       770       780       790     

              760       770       780       790       800       810
pF1KSD ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
         800       810       820       830       840       850     

              820       830       840       850       860       870
pF1KSD QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
         860       870       880       890       900       910     

              880       890       900       910                    
pF1KSD RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKE------------------
       ::::::::::::::::::::::::::::::::::::::::::                  
XP_016 RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEAELLISESSEMGLGTKAL
         920       930       940       950       960       970     

                                                                   
pF1KSD ------------------------------------------------------------
                                                                   
XP_016 GLFPGSSQAGASSVSLTPPASTLLCPKAQEYVMLEQLKVMRGTSPMPPAPVPGLSPWASA
         980       990      1000      1010      1020      1030     

                                       920       930       940     
pF1KSD ---------------------------MEKLLLPAVDLEQWYQELMAGLGTGPAAASPHS
                                  :::::::::::::::::::::::::::::::::
XP_016 SRDLVPTTCLPPMLPSSSFASITPSPKMEKLLLPAVDLEQWYQELMAGLGTGPAAASPHS
        1040      1050      1060      1070      1080      1090     

         950       960       970       980       990      1000     
pF1KSD SPPPLPAKASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPPPLPAKASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSP
        1100      1110      1120      1130      1140      1150     

        1010      1020      1030      1040                     1050
pF1KSD KSALLTQNGTGSLPRNLAATLQDIETKRQLALQQK---------------GQQVIEEQRR
       :::::::::::::::::::::::::::::::::::               ::::::::::
XP_016 KSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKVESLPAEPLPTDDPAGQQVIEEQRR
        1160      1170      1180      1190      1200      1210     

             1060      1070      1080      1090      1100      1110
pF1KSD RLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYD
        1220      1230      1240      1250      1260      1270     

             1120      1130      1140      1150      1160      1170
pF1KSD TLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESRE
        1280      1290      1300      1310      1320      1330     

             1180      1190      1200      1210      1220      1230
pF1KSD REMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 REMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRK
        1340      1350      1360      1370      1380      1390     

             1240      1250      1260      1270      1280      1290
pF1KSD EDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: 
XP_016 EDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYY
        1400      1410      1420      1430      1440      1450     

             1300      1310      1320      1330      1340      1350
pF1KSD VDKHETKLKGVIYFQAIEEVYYDHLRSAAKKRFFRFTMVTESPNPALTFCVKTHDRLYYM
                                                                   
XP_016 VDKHETKLKGVIYFQAIEEVYYDHLRSAAKKRFFRFTMVTESPNPALTFCVKTHDRLYYM
        1460      1470      1480      1490      1500      1510     

>--
 initn: 588 init1: 588 opt: 588  Z-score: 266.4  bits: 61.9 E(85289): 4.2e-08
Smith-Waterman score: 588; 100.0% identity (100.0% similar) in 88 aa overlap (1290-1377:1455-1542)

    1260      1270      1280      1290      1300      1310         
pF1KSD RGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAA
                                     ::::::::::::::::::::::::::::::
XP_016 RGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAA
         1430      1440      1450      1460      1470      1480    

    1320      1330      1340      1350      1360      1370       
pF1KSD KKRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
         1490      1500      1510      1520      1530      1540  




1377 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 02:25:39 2016 done: Thu Nov  3 02:25:41 2016
 Total Scan time: 15.170 Total Display time:  0.660

Function used was FASTA [36.3.4 Apr, 2011]
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