Result of FASTA (omim) for pF1KSDA0422
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KSDA0422, 1115 aa
  1>>>pF1KSDA0422 1115 - 1115 aa - 1115 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 6.1872+/-0.000398; mu= 18.5813+/- 0.025
 mean_var=92.5879+/-18.991, 0's: 0 Z-trim(113.7): 112  B-trim: 216 in 1/51
 Lambda= 0.133290
 statistics sampled from 23030 (23147) to 23030 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.617), E-opt: 0.2 (0.271), width:  16
 Scan time: 10.100

The best scores are:                                      opt bits E(85289)
XP_006719273 (OMIM: 600294,616287) PREDICTED: aden (1168) 5113 994.3       0
NP_056085 (OMIM: 600294,616287) adenylate cyclase  (1168) 5113 994.3       0
XP_016874232 (OMIM: 600294,616287) PREDICTED: aden (1067) 4477 871.9       0
NP_899200 (OMIM: 600293,606703) adenylate cyclase  (1261) 3066 600.7 1.8e-170
XP_005247134 (OMIM: 600293,606703) PREDICTED: aden (1286) 3066 600.7 1.9e-170
XP_016861128 (OMIM: 600293,606703) PREDICTED: aden ( 920) 2421 476.5 3.1e-133
NP_001186571 (OMIM: 600293,606703) adenylate cycla ( 911) 2416 475.6  6e-133
XP_005247135 (OMIM: 600293,606703) PREDICTED: aden ( 936) 2416 475.6 6.1e-133
XP_011510662 (OMIM: 600293,606703) PREDICTED: aden ( 923) 2409 474.2 1.5e-132
XP_011510661 (OMIM: 600293,606703) PREDICTED: aden ( 953) 2409 474.2 1.6e-132
XP_016861127 (OMIM: 600293,606703) PREDICTED: aden ( 920) 2408 474.0 1.7e-132
XP_006713546 (OMIM: 600293,606703) PREDICTED: aden ( 919) 2407 473.8  2e-132
XP_005250826 (OMIM: 103070) PREDICTED: adenylate c (1221) 1965 388.9 9.7e-107
XP_016861129 (OMIM: 600293,606703) PREDICTED: aden ( 845) 1668 331.7 1.1e-89
XP_006713547 (OMIM: 600293,606703) PREDICTED: aden ( 845) 1668 331.7 1.1e-89
XP_011510663 (OMIM: 600293,606703) PREDICTED: aden ( 845) 1668 331.7 1.1e-89
NP_001106 (OMIM: 103070) adenylate cyclase type 8  (1251) 1485 296.6   6e-79
XP_011512244 (OMIM: 103071) PREDICTED: adenylate c (1045) 1371 274.7 2.1e-72
XP_016868495 (OMIM: 103070) PREDICTED: adenylate c (1155) 1317 264.3   3e-69
XP_006716564 (OMIM: 103070) PREDICTED: adenylate c (1185) 1317 264.3 3.1e-69
XP_005249642 (OMIM: 103072,610154,610154) PREDICTE ( 563) 1312 263.2 3.2e-69
XP_005249641 (OMIM: 103072,610154,610154) PREDICTE ( 979) 1312 263.3 5.1e-69
NP_066939 (OMIM: 103072,610154,610154) adenylate c (1119) 1312 263.3 5.7e-69
XP_016868496 (OMIM: 103070) PREDICTED: adenylate c ( 646) 1305 261.8 9.2e-69
NP_001268697 (OMIM: 103072,610154,610154) adenylat ( 338) 1164 234.6 7.8e-61
XP_016858679 (OMIM: 600291) PREDICTED: adenylate c (1098) 1079 218.5 1.7e-55
NP_004027 (OMIM: 600291) adenylate cyclase type 3  (1144) 1068 216.4 7.7e-55
NP_001307542 (OMIM: 600291) adenylate cyclase type (1145) 1068 216.4 7.7e-55
XP_016858676 (OMIM: 600291) PREDICTED: adenylate c (1163) 1068 216.4 7.8e-55
XP_011530793 (OMIM: 600291) PREDICTED: adenylate c (1164) 1068 216.4 7.8e-55
XP_016858682 (OMIM: 600291) PREDICTED: adenylate c ( 903)  986 200.6 3.6e-50
XP_016858681 (OMIM: 600291) PREDICTED: adenylate c ( 904)  986 200.6 3.6e-50
XP_011530796 (OMIM: 600291) PREDICTED: adenylate c (1120)  910 186.0 1.1e-45
XP_016858678 (OMIM: 600291) PREDICTED: adenylate c (1139)  910 186.0 1.1e-45
XP_011530795 (OMIM: 600291) PREDICTED: adenylate c (1140)  910 186.0 1.1e-45
XP_016858677 (OMIM: 600291) PREDICTED: adenylate c (1149)  910 186.0 1.1e-45
XP_011530794 (OMIM: 600291) PREDICTED: adenylate c (1150)  910 186.0 1.1e-45
XP_016858675 (OMIM: 600291) PREDICTED: adenylate c (1166)  910 186.0 1.1e-45
XP_006711988 (OMIM: 600291) PREDICTED: adenylate c (1167)  910 186.0 1.1e-45
XP_011530792 (OMIM: 600291) PREDICTED: adenylate c (1185)  910 186.0 1.1e-45
XP_011530791 (OMIM: 600291) PREDICTED: adenylate c (1186)  910 186.0 1.1e-45
XP_016858680 (OMIM: 600291) PREDICTED: adenylate c ( 974)  886 181.4 2.3e-44
NP_065433 (OMIM: 103071) adenylate cyclase type 2  (1091)  872 178.7 1.6e-43
XP_016878388 (OMIM: 600385) PREDICTED: adenylate c ( 723)  867 177.7 2.3e-43
NP_001272986 (OMIM: 600385) adenylate cyclase type ( 734)  867 177.7 2.3e-43
XP_016878387 (OMIM: 600385) PREDICTED: adenylate c ( 734)  867 177.7 2.3e-43
XP_016878385 (OMIM: 600385) PREDICTED: adenylate c ( 886)  867 177.7 2.7e-43
XP_016878386 (OMIM: 600385) PREDICTED: adenylate c ( 886)  867 177.7 2.7e-43
NP_001105 (OMIM: 600385) adenylate cyclase type 7  (1080)  867 177.8 3.2e-43
XP_016878384 (OMIM: 600385) PREDICTED: adenylate c (1080)  867 177.8 3.2e-43


>>XP_006719273 (OMIM: 600294,616287) PREDICTED: adenylat  (1168 aa)
 initn: 5102 init1: 5102 opt: 5113  Z-score: 5309.2  bits: 994.3 E(85289):    0
Smith-Waterman score: 7135; 95.4% identity (95.4% similar) in 1147 aa overlap (1-1094:1-1147)

               10        20        30        40        50        60
pF1KSD MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGP
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD PRCPWQDDAFIRRGGPGKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRSCWR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PRCPWQDDAFIRRGGPGKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRSCWR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD RLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAY
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD VALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLW
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD CPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTN
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD VIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINT
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD KKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHC
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD LRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRV
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KSD HCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNA
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KSD YLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFR
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KSD QMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKK
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KSD YSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSC
              670       680       690       700       710       720

              730       740       750       760                    
pF1KSD GSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANM-------------------
       :::::::::::::::::::::::::::::::::::::::::                   
XP_006 GSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMFTCNHTPIRSCAARMLNLT
              730       740       750       760       770       780

                                               770       780       
pF1KSD ----------------------------------YFIGNMLLSLLASSVFLHISSIGKLA
                                         ::::::::::::::::::::::::::
XP_006 PADITACHLQQLNYSLGLDAPLCEGTMPTCSFPEYFIGNMLLSLLASSVFLHISSIGKLA
              790       800       810       820       830       840

       790       800       810       820       830       840       
pF1KSD MIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPV
              850       860       870       880       890       900

       850       860       870       880       890       900       
pF1KSD ILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHF
              910       920       930       940       950       960

       910       920       930       940       950       960       
pF1KSD LARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIIS
              970       980       990      1000      1010      1020

       970       980       990      1000      1010      1020       
pF1KSD EERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNN
             1030      1040      1050      1060      1070      1080

      1030      1040      1050      1060      1070      1080       
pF1KSD FQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKG
             1090      1100      1110      1120      1130      1140

      1090      1100      1110     
pF1KSD YQLECRGVVKVKGKGEMTTYFLNGGPSS
       :::::::                     
XP_006 YQLECRGVVKVKGKGEMTTYFLNGGPSS
             1150      1160        

>>NP_056085 (OMIM: 600294,616287) adenylate cyclase type  (1168 aa)
 initn: 5102 init1: 5102 opt: 5113  Z-score: 5309.2  bits: 994.3 E(85289):    0
Smith-Waterman score: 7135; 95.4% identity (95.4% similar) in 1147 aa overlap (1-1094:1-1147)

               10        20        30        40        50        60
pF1KSD MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGP
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD PRCPWQDDAFIRRGGPGKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRSCWR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 PRCPWQDDAFIRRGGPGKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRSCWR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD RLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 RLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAY
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD VALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 VALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLW
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD CPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 CPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTN
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD VIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 VIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINT
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD KKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 KKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHC
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD LRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRV
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KSD HCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 HCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNA
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KSD YLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 YLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFR
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KSD QMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 QMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKK
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KSD YSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 YSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSC
              670       680       690       700       710       720

              730       740       750       760                    
pF1KSD GSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANM-------------------
       :::::::::::::::::::::::::::::::::::::::::                   
NP_056 GSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMFTCNHTPIRSCAARMLNLT
              730       740       750       760       770       780

                                               770       780       
pF1KSD ----------------------------------YFIGNMLLSLLASSVFLHISSIGKLA
                                         ::::::::::::::::::::::::::
NP_056 PADITACHLQQLNYSLGLDAPLCEGTMPTCSFPEYFIGNMLLSLLASSVFLHISSIGKLA
              790       800       810       820       830       840

       790       800       810       820       830       840       
pF1KSD MIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 MIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPV
              850       860       870       880       890       900

       850       860       870       880       890       900       
pF1KSD ILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 ILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHF
              910       920       930       940       950       960

       910       920       930       940       950       960       
pF1KSD LARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIIS
              970       980       990      1000      1010      1020

       970       980       990      1000      1010      1020       
pF1KSD EERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 EERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNN
             1030      1040      1050      1060      1070      1080

      1030      1040      1050      1060      1070      1080       
pF1KSD FQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 FQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKG
             1090      1100      1110      1120      1130      1140

      1090      1100      1110     
pF1KSD YQLECRGVVKVKGKGEMTTYFLNGGPSS
       :::::::                     
NP_056 YQLECRGVVKVKGKGEMTTYFLNGGPSS
             1150      1160        

>>XP_016874232 (OMIM: 600294,616287) PREDICTED: adenylat  (1067 aa)
 initn: 6732 init1: 4457 opt: 4477  Z-score: 4648.8  bits: 871.9 E(85289):    0
Smith-Waterman score: 6646; 91.7% identity (92.9% similar) in 1121 aa overlap (1-1115:1-1067)

               10        20        30        40        50        60
pF1KSD MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGP
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD PRCPWQDDAFIRRGGPGKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRSCWR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRCPWQDDAFIRRGGPGKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRSCWR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD RLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAY
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD VALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLW
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD CPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTN
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD VIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINT
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD KKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHC
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD LRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRV
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KSD HCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNA
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KSD YLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFR
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KSD QMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKK
              610       620       630       640       650       660

              670       680             690       700       710    
pF1KSD YSRKVDPRFGAYVACALLVFCFI------CFIQLLIFPHSTLMLGIYASIFLLLLITVLI
       .. .  :      .::  .. .       : .: : .      ::. :    :   :.  
XP_016 FTCNHTP----IRSCAARMLNLTPADITACHLQQLNYS-----LGLDAP---LCEGTMPT
                  670       680       690            700           

          720       730       740       750       760       770    
pF1KSD CAVYSCGSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMYFIGNMLLSLLAS
       :.       ::.                                   :::::::::::::
XP_016 CS-------FPE-----------------------------------YFIGNMLLSLLAS
      710                                                 720      

          780       790       800       810       820       830    
pF1KSD SVFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCP
        730       740       750       760       770       780      

          840       850       860       870       880       890    
pF1KSD AAGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRL
        790       800       810       820       830       840      

          900       910       920       930       940       950    
pF1KSD LHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRL
        850       860       870       880       890       900      

          960       970       980       990      1000      1010    
pF1KSD LNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLM
        910       920       930       940       950       960      

         1020      1030      1040      1050      1060      1070    
pF1KSD EQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQ
        970       980       990      1000      1010      1020      

         1080      1090      1100      1110     
pF1KSD VTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLNGGPSS
       :::::::::::::::::::::::::::::::::::::::::
XP_016 VTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLNGGPSS
       1030      1040      1050      1060       

>>NP_899200 (OMIM: 600293,606703) adenylate cyclase type  (1261 aa)
 initn: 4783 init1: 2353 opt: 3066  Z-score: 3181.3  bits: 600.7 E(85289): 1.8e-170
Smith-Waterman score: 4638; 65.7% identity (80.2% similar) in 1146 aa overlap (16-1092:100-1237)

                              10        20             30        40
pF1KSD                MSWFSGLLVPKVDERKTAWGERNGQ-----KRSRRRGTRAGGFCT
                                     :.:: ::.:.     .: .:::. .::   
NP_899 ASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRRQRRGAASGGSTR
      70        80        90       100       110       120         

               50        60        70          80        90        
pF1KSD PRYMSCLRDAEPPSPTPAGPPRCPWQDDAFI--RRGGPGKGKELGLRAVALGFEDTEVTT
           .    .   . . .:    : . .. .  :::    . ::   ::  :  . .  .
NP_899 APPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAGAVEGGEGSGDGGS
     130       140       150       160       170       180         

      100       110       120       130       140       150        
pF1KSD TAGGTAEVAPDAVPRSGRSCWRRLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAV
       .: . . ..: ::   :  :   :.:.:.::.: : :::::::::::..::::::.::::
NP_899 SADSGSGAGPGAVLSLGACCLA-LLQIFRSKKFPSDKLERLYQRYFFRLNQSSLTMLMAV
     190       200       210        220       230       240        

      160       170         180       190       200       210      
pF1KSD LVLLTAVLLAFHAAPARP--QPAYVALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVL
       :::.  :.:::::  :::  :  :.:.:: :..... . :.::: .:.:: : .. :...
NP_899 LVLVCLVMLAFHA--ARPPLQLPYLAVLAAAVGVILIMAVLCNRAAFHQDHMGLACYALI
      250       260         270       280       290       300      

        220       230       240       250       260       270      
pF1KSD GILAAVQVGGALAADPRSPSAGLWCPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAW
       ... :::: : :  .::: : :.:  :::.:  :::::.:::::::::. ::.::: .: 
NP_899 AVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSALHLAIAL
        310       320       330       340       350       360      

        280       290       300       310       320       330      
pF1KSD QLNRGDAFLWKQLGANVLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENR
       . :  : :: ::: .:::.: :::..:.::::::::::::::::::  :::::: :.::.
NP_899 RTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQ
        370       380       390       400       410       420      

        340       350       360       370       380       390      
pF1KSD QQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCT
       :::::::::::.::::::: :::.:.::::::::::::::::::::::::::::::::::
NP_899 QQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCT
        430       440       450       460       470       480      

        400       410       420       430       440       450      
pF1KSD AQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIE
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::.::::
NP_899 AQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIE
        490       500       510       520       530       540      

        460       470       480       490       500       510      
pF1KSD AISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHI
       :::::::::::::::::::::::::::::::::::::::::::::::::::::.::::::
NP_899 AISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHI
        550       560       570       580       590       600      

        520       530       540       550       560       570      
pF1KSD TRATLQYLNGDYEVEPGRGGERNAYLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANS
       :.:::.::::::::::: ::::::::::. :::::::  .:::::::::.::..: :.::
NP_899 TKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMNRQRTNS
        610       620       630       640       650       660      

        580       590           600       610       620       630  
pF1KSD MEGLMPRWVPDRAFSR----TKDSKAFRQMGIDDSSKDNRGTQDALNPEDEVDEFLSRAI
       .    :.:  .: :      .. :: ...::..:  :: ...:.. ::::::::::.:::
NP_899 IGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDP-KD-KNAQESANPEDEVDEFLGRAI
        670       680       690       700         710       720    

            640       650       660       670       680       690  
pF1KSD DARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIFP
       ::::::.::..:::.:::::.. :::::::..:: ::::::::: ::: ::::.:. : :
NP_899 DARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVP
          730       740       750       760       770       780    

            700       710       720       730       740       750  
pF1KSD HSTLMLGIYASIFLLLLITVLICAVYSCGSLFPKALQRLSRSIVRSRAHSTAVGIFSVLL
       :: .::..: .  ::: ..:.. ..::: .:::. :: :::.::::. .:: ::.:.. :
NP_899 HSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTLSRKIVRSKMNSTLVGVFTITL
          790       800       810       820       830       840    

            760                                                    
pF1KSD VFTSAIANM---------------------------------------------------
       :: .:..::                                                   
NP_899 VFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCGSPWPNC
          850       860       870       880       890       900    

                 770       780       790       800       810       
pF1KSD ----YFIGNMLLSLLASSVFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLG
           ::  ..:::::: ::::.:: ::::...... ::: ::..  : .:.::: :::. 
NP_899 NFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIY-VLIVEVPGVTLFDNADLLVT
          910       920       930       940        950       960   

       820       830        840       850       860       870      
pF1KSD VHGLASSNETFDGLDCPA-AGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQ
       ....   :.  .  .::  : .:::: .::.:. ::.:::::::::::::::::::::::
NP_899 ANAIDFFNNGTS--QCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQ
           970         980       990      1000      1010      1020 

        880       890       900       910       920       930      
pF1KSD ATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFS
       :: :::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_899 ATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFS
            1030      1040      1050      1060      1070      1080 

        940       950       960       970       980       990      
pF1KSD EFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYD
       ::::::::::::::::::::::::::::::::.:::::::::::::::::::::: ::::
NP_899 EFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYD
            1090      1100      1110      1120      1130      1140 

       1000      1010      1020      1030      1040      1050      
pF1KSD QVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGN
       .::..:: ::::.::.::.:::.::::::::::::::::.::::::::::::::::::::
NP_899 KVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGN
            1150      1160      1170      1180      1190      1200 

       1060      1070      1080      1090      1100      1110      
pF1KSD TVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLNGGPSS 
       ::::.:::::::::::::::::.::::::. :::::                        
NP_899 TVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS
            1210      1220      1230      1240      1250      1260 

>>XP_005247134 (OMIM: 600293,606703) PREDICTED: adenylat  (1286 aa)
 initn: 4735 init1: 2353 opt: 3066  Z-score: 3181.2  bits: 600.7 E(85289): 1.9e-170
Smith-Waterman score: 4439; 63.9% identity (78.2% similar) in 1144 aa overlap (16-1067:100-1237)

                              10        20             30        40
pF1KSD                MSWFSGLLVPKVDERKTAWGERNGQ-----KRSRRRGTRAGGFCT
                                     :.:: ::.:.     .: .:::. .::   
XP_005 ASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRRQRRGAASGGSTR
      70        80        90       100       110       120         

               50        60        70          80        90        
pF1KSD PRYMSCLRDAEPPSPTPAGPPRCPWQDDAFI--RRGGPGKGKELGLRAVALGFEDTEVTT
           .    .   . . .:    : . .. .  :::    . ::   ::  :  . .  .
XP_005 APPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAGAVEGGEGSGDGGS
     130       140       150       160       170       180         

      100       110       120       130       140       150        
pF1KSD TAGGTAEVAPDAVPRSGRSCWRRLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAV
       .: . . ..: ::   :  :   :.:.:.::.: : :::::::::::..::::::.::::
XP_005 SADSGSGAGPGAVLSLGACCLA-LLQIFRSKKFPSDKLERLYQRYFFRLNQSSLTMLMAV
     190       200       210        220       230       240        

      160       170         180       190       200       210      
pF1KSD LVLLTAVLLAFHAAPARP--QPAYVALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVL
       :::.  :.::::::  ::  :  :.:.:: :..... . :.::: .:.:: : .. :...
XP_005 LVLVCLVMLAFHAA--RPPLQLPYLAVLAAAVGVILIMAVLCNRAAFHQDHMGLACYALI
      250       260         270       280       290       300      

        220       230       240       250       260       270      
pF1KSD GILAAVQVGGALAADPRSPSAGLWCPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAW
       ... :::: : :  .::: : :.:  :::.:  :::::.:::::::::. ::.::: .: 
XP_005 AVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSALHLAIAL
        310       320       330       340       350       360      

        280       290       300       310       320       330      
pF1KSD QLNRGDAFLWKQLGANVLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENR
       . :  : :: ::: .:::.: :::..:.::::::::::::::::::  :::::: :.::.
XP_005 RTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQ
        370       380       390       400       410       420      

        340       350       360       370       380       390      
pF1KSD QQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCT
       :::::::::::.::::::: :::.:.::::::::::::::::::::::::::::::::::
XP_005 QQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCT
        430       440       450       460       470       480      

        400       410       420       430       440       450      
pF1KSD AQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIE
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::.::::
XP_005 AQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIE
        490       500       510       520       530       540      

        460       470       480       490       500       510      
pF1KSD AISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHI
       :::::::::::::::::::::::::::::::::::::::::::::::::::::.::::::
XP_005 AISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHI
        550       560       570       580       590       600      

        520       530       540       550       560       570      
pF1KSD TRATLQYLNGDYEVEPGRGGERNAYLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANS
       :.:::.::::::::::: ::::::::::. :::::::  .:::::::::.::..: :.::
XP_005 TKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMNRQRTNS
        610       620       630       640       650       660      

        580       590           600       610       620       630  
pF1KSD MEGLMPRWVPDRAFSR----TKDSKAFRQMGIDDSSKDNRGTQDALNPEDEVDEFLSRAI
       .    :.:  .: :      .. :: ...::..:  :: ...:.. ::::::::::.:::
XP_005 IGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDP-KD-KNAQESANPEDEVDEFLGRAI
        670       680       690       700         710       720    

            640       650       660       670       680       690  
pF1KSD DARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIFP
       ::::::.::..:::.:::::.. :::::::..:: ::::::::: ::: ::::.:. : :
XP_005 DARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVP
          730       740       750       760       770       780    

            700       710       720       730       740       750  
pF1KSD HSTLMLGIYASIFLLLLITVLICAVYSCGSLFPKALQRLSRSIVRSRAHSTAVGIFSVLL
       :: .::..: .  ::: ..:.. ..::: .:::. :: :::.::::. .:: ::.:.. :
XP_005 HSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTLSRKIVRSKMNSTLVGVFTITL
          790       800       810       820       830       840    

            760                                                    
pF1KSD VFTSAIANM---------------------------------------------------
       :: .:..::                                                   
XP_005 VFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCGSPWPNC
          850       860       870       880       890       900    

                 770       780       790       800       810       
pF1KSD ----YFIGNMLLSLLASSVFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLG
           ::  ..:::::: ::::.:: ::::...... ::: ::..  : .:.::: :::. 
XP_005 NFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIY-VLIVEVPGVTLFDNADLLVT
          910       920       930       940        950       960   

       820                      830                840       850   
pF1KSD VHGLASSNETFD---------------GLDCPA---------AGRVALKYMTPVILLVFA
       ....   :.  .               :   :.         : .:::: .::.:. ::.
XP_005 ANAIDFFNNGTSQWSLCENLRHRRMEAGTYFPSGVKEQSPEHATKVALKVVTPIIISVFV
           970       980       990      1000      1010      1020   

           860       870       880       890       900       910   
pF1KSD LALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERR
       ::::::::::::::::::::::::: ::::::::::::::::::::::::::::::::::
XP_005 LALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERR
          1030      1040      1050      1060      1070      1080   

           920       930       940       950       960       970   
pF1KSD NDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQ
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::.::::
XP_005 NDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQ
          1090      1100      1110      1120      1130      1140   

           980       990      1000      1010      1020      1030   
pF1KSD LEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIG
       :::::::::::::::::: ::::.::..:: ::::.::.::.:::.::::::::::::::
XP_005 LEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIG
          1150      1160      1170      1180      1190      1200   

          1040      1050      1060      1070      1080      1090   
pF1KSD LNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECR
       ::.::::::::::::::::::::::::.::::::                          
XP_005 LNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECR
          1210      1220      1230      1240      1250      1260   

          1100      1110      
pF1KSD GVVKVKGKGEMTTYFLNGGPSS 
                              
XP_005 GVVKVKGKGEMMTYFLNGGPPLS
          1270      1280      

>--
 initn: 283 init1: 283 opt: 283  Z-score: 288.9  bits: 65.5 E(85289): 2.4e-09
Smith-Waterman score: 283; 91.3% identity (95.7% similar) in 46 aa overlap (1068-1113:1238-1283)

      1040      1050      1060      1070      1080      1090       
pF1KSD PVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVK
                                     :::::::::::.::::::. ::::::::::
XP_005 PVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVK
      1210      1220      1230      1240      1250      1260       

      1100      1110      
pF1KSD VKGKGEMTTYFLNGGPSS 
       ::::::: ::::::::   
XP_005 VKGKGEMMTYFLNGGPPLS
      1270      1280      

>>XP_016861128 (OMIM: 600293,606703) PREDICTED: adenylat  (920 aa)
 initn: 4158 init1: 1776 opt: 2421  Z-score: 2513.0  bits: 476.5 E(85289): 3.1e-133
Smith-Waterman score: 3794; 70.2% identity (82.2% similar) in 865 aa overlap (286-1067:10-871)

         260       270       280       290       300       310     
pF1KSD RMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTNVIGICTHYPAEVSQR
                                     : .: .:::.: :::..:.:::::::::::
XP_016                      MQTSACCPEWAKLVSNVLIFSCTNIVGVCTHYPAEVSQR
                                    10        20        30         

         320       330       340       350       360       370     
pF1KSD QAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKH
       :::::::  :::::: :.::.:::::::::::.::::::: :::.:.:::::::::::::
XP_016 QAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKH
      40        50        60        70        80        90         

         380       390       400       410       420       430     
pF1KSD DNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSG
     100       110       120       130       140       150         

         440       450       460       470       480       490     
pF1KSD LPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVW
       ::::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::
XP_016 LPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVW
     160       170       180       190       200       210         

         500       510       520       530       540       550     
pF1KSD SNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQHIETFLILGA
       ::::::::::::::.:::::::.:::.::::::::::: ::::::::::. :::::::  
XP_016 SNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRC
     220       230       240       250       260       270         

         560       570       580       590           600       610 
pF1KSD SQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSR----TKDSKAFRQMGIDDSSKDN
       .:::::::::.::..: :.::.    :.:  .: :      .. :: ...::..:  :: 
XP_016 TQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDP-KD-
     280       290       300       310       320       330         

             620       630       640       650       660       670 
pF1KSD RGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGA
       ...:.. ::::::::::.:::::::::.::..:::.:::::.. :::::::..:: ::::
XP_016 KNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGA
       340       350       360       370       380       390       

             680       690       700       710       720       730 
pF1KSD YVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSCGSLFPKALQRL
       ::::: ::: ::::.:. : ::: .::..: .  ::: ..:.. ..::: .:::. :: :
XP_016 YVACASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTL
       400       410       420       430       440       450       

             740       750       760                               
pF1KSD SRSIVRSRAHSTAVGIFSVLLVFTSAIANM------------------------------
       ::.::::. .:: ::.:.. ::: .:..::                              
XP_016 SRKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAE
       460       470       480       490       500       510       

                                      770       780       790      
pF1KSD -------------------------YFIGNMLLSLLASSVFLHISSIGKLAMIFVLGLIY
                                ::  ..:::::: ::::.:: ::::...... :::
XP_016 SAVNYSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIY
       520       530       540       550       560       570       

        800       810       820                      830           
pF1KSD LVLLLLGPPATIFDNYDLLLGVHGLASSNETFD---------------GLDCPA------
        ::..  : .:.::: :::. ....   :.  .               :   :.      
XP_016 -VLIVEVPGVTLFDNADLLVTANAIDFFNNGTSQWSLCENLRHRRMEAGTYFPSGVKEQS
        580       590       600       610       620       630      

            840       850       860       870       880       890  
pF1KSD ---AGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNR
          : .:::: .::.:. ::.::::::::::::::::::::::::: :::::::::::::
XP_016 PEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNR
        640       650       660       670       680       690      

            900       910       920       930       940       950  
pF1KSD RLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECL
        700       710       720       730       740       750      

            960       970       980       990      1000      1010  
pF1KSD RLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMR
       ::::::::::::::::.:::::::::::::::::::::: ::::.::..:: ::::.::.
XP_016 RLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMK
        760       770       780       790       800       810      

           1020      1030      1040      1050      1060      1070  
pF1KSD LMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDR
       ::.:::.::::::::::::::::.::::::::::::::::::::::::.::::::     
XP_016 LMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDR
        820       830       840       850       860       870      

           1080      1090      1100      1110      
pF1KSD IQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLNGGPSS 
                                                   
XP_016 IQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS
        880       890       900       910       920

>--
 initn: 283 init1: 283 opt: 283  Z-score: 291.1  bits: 65.4 E(85289): 1.8e-09
Smith-Waterman score: 283; 91.3% identity (95.7% similar) in 46 aa overlap (1068-1113:872-917)

      1040      1050      1060      1070      1080      1090       
pF1KSD PVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVK
                                     :::::::::::.::::::. ::::::::::
XP_016 PVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVK
             850       860       870       880       890       900 

      1100      1110      
pF1KSD VKGKGEMTTYFLNGGPSS 
       ::::::: ::::::::   
XP_016 VKGKGEMMTYFLNGGPPLS
             910       920

>>NP_001186571 (OMIM: 600293,606703) adenylate cyclase t  (911 aa)
 initn: 4194 init1: 1764 opt: 2416  Z-score: 2507.9  bits: 475.6 E(85289): 6e-133
Smith-Waterman score: 3988; 71.8% identity (84.3% similar) in 879 aa overlap (274-1092:14-887)

           250       260       270       280       290       300   
pF1KSD FFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTNVIG
                                     :. : . :  .  ..: .:::.: :::..:
NP_001                  MKSQKEGCCSRGDLSIQTGPGGEWAPRRLVSNVLIFSCTNIVG
                                10        20        30        40   

           310       320       330       340       350       360   
pF1KSD ICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKE
       .::::::::::::::::::  :::::: :.::.:::::::::::.::::::: :::.:.:
NP_001 VCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQE
            50        60        70        80        90       100   

           370       380       390       400       410       420   
pF1KSD DMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRI
           110       120       130       140       150       160   

           430       440       450       460       470       480   
pF1KSD KILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCG
       ::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::
NP_001 KILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCG
           170       180       190       200       210       220   

           490       500       510       520       530       540   
pF1KSD VLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLK
       ::::::::::::::::::::::::::.:::::::.:::.::::::::::: :::::::::
NP_001 VLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLK
           230       240       250       260       270       280   

           550       560       570       580       590             
pF1KSD EQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSR----TKDSKAF
       :. :::::::  .:::::::::.::..: :.::.    :.:  .: :      .. :: .
NP_001 EHSIETFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEM
           290       300       310       320       330       340   

     600       610       620       630       640       650         
pF1KSD RQMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEK
       ..::..:  :: ...:.. ::::::::::.:::::::::.::..:::.:::::.. ::::
NP_001 KRMGFEDP-KD-KNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEK
           350         360       370       380       390       400 

     660       670       680       690       700       710         
pF1KSD KYSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYS
       :::..:: ::::::::: ::: ::::.:. : ::: .::..: .  ::: ..:.. ..::
NP_001 KYSKQVDDRFGAYVACASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYS
             410       420       430       440       450       460 

     720       730       740       750       760                   
pF1KSD CGSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANM------------------
       : .:::. :: :::.::::. .:: ::.:.. ::: .:..::                  
NP_001 CVKLFPSPLQTLSRKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNI
             470       480       490       500       510       520 

                                                  770       780    
pF1KSD -------------------------------------YFIGNMLLSLLASSVFLHISSIG
                                            ::  ..:::::: ::::.:: ::
NP_001 SASQVNACHVAESAVNYSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIG
             530       540       550       560       570       580 

          790       800       810       820       830        840   
pF1KSD KLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPA-AGRVALKY
       ::...... ::: ::..  : .:.::: :::. ....   :.  .  .::  : .:::: 
NP_001 KLVLMLAIELIY-VLIVEVPGVTLFDNADLLVTANAIDFFNNGTS--QCPEHATKVALKV
             590        600       610       620         630        

           850       860       870       880       890       900   
pF1KSD MTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDV
       .::.:. ::.::::::::::::::::::::::::: ::::::::::::::::::::::::
NP_001 VTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDV
      640       650       660       670       680       690        

           910       920       930       940       950       960   
pF1KSD AAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFD
      700       710       720       730       740       750        

           970       980       990      1000      1010      1020   
pF1KSD EIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEH
       :::::.:::::::::::::::::::::: ::::.::..:: ::::.::.::.:::.::::
NP_001 EIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMDQMKYINEH
      760       770       780       790       800       810        

          1030      1040      1050      1060      1070      1080   
pF1KSD SFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVL
       ::::::::::::.::::::::::::::::::::::::.:::::::::::::::::.::::
NP_001 SFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVL
      820       830       840       850       860       870        

          1090      1100      1110      
pF1KSD AAKGYQLECRGVVKVKGKGEMTTYFLNGGPSS 
       ::. :::::                        
NP_001 AANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS
      880       890       900       910 

>>XP_005247135 (OMIM: 600293,606703) PREDICTED: adenylat  (936 aa)
 initn: 4146 init1: 1764 opt: 2416  Z-score: 2507.7  bits: 475.6 E(85289): 6.1e-133
Smith-Waterman score: 3789; 69.4% identity (81.8% similar) in 877 aa overlap (274-1067:14-887)

           250       260       270       280       290       300   
pF1KSD FFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTNVIG
                                     :. : . :  .  ..: .:::.: :::..:
XP_005                  MKSQKEGCCSRGDLSIQTGPGGEWAPRRLVSNVLIFSCTNIVG
                                10        20        30        40   

           310       320       330       340       350       360   
pF1KSD ICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKE
       .::::::::::::::::::  :::::: :.::.:::::::::::.::::::: :::.:.:
XP_005 VCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQE
            50        60        70        80        90       100   

           370       380       390       400       410       420   
pF1KSD DMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRI
           110       120       130       140       150       160   

           430       440       450       460       470       480   
pF1KSD KILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCG
       ::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::
XP_005 KILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCG
           170       180       190       200       210       220   

           490       500       510       520       530       540   
pF1KSD VLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLK
       ::::::::::::::::::::::::::.:::::::.:::.::::::::::: :::::::::
XP_005 VLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLK
           230       240       250       260       270       280   

           550       560       570       580       590             
pF1KSD EQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSR----TKDSKAF
       :. :::::::  .:::::::::.::..: :.::.    :.:  .: :      .. :: .
XP_005 EHSIETFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEM
           290       300       310       320       330       340   

     600       610       620       630       640       650         
pF1KSD RQMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEK
       ..::..:  :: ...:.. ::::::::::.:::::::::.::..:::.:::::.. ::::
XP_005 KRMGFEDP-KD-KNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEK
           350         360       370       380       390       400 

     660       670       680       690       700       710         
pF1KSD KYSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYS
       :::..:: ::::::::: ::: ::::.:. : ::: .::..: .  ::: ..:.. ..::
XP_005 KYSKQVDDRFGAYVACASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYS
             410       420       430       440       450       460 

     720       730       740       750       760                   
pF1KSD CGSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANM------------------
       : .:::. :: :::.::::. .:: ::.:.. ::: .:..::                  
XP_005 CVKLFPSPLQTLSRKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNI
             470       480       490       500       510       520 

                                                  770       780    
pF1KSD -------------------------------------YFIGNMLLSLLASSVFLHISSIG
                                            ::  ..:::::: ::::.:: ::
XP_005 SASQVNACHVAESAVNYSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIG
             530       540       550       560       570       580 

          790       800       810       820                        
pF1KSD KLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFD---------------
       ::...... ::: ::..  : .:.::: :::. ....   :.  .               
XP_005 KLVLMLAIELIY-VLIVEVPGVTLFDNADLLVTANAIDFFNNGTSQWSLCENLRHRRMEA
             590        600       610       620       630       640

     830                840       850       860       870       880
pF1KSD GLDCPA---------AGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGE
       :   :.         : .:::: .::.:. ::.::::::::::::::::::::::::: :
XP_005 GTYFPSGVKEQSPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEE
              650       660       670       680       690       700

              890       900       910       920       930       940
pF1KSD KEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYV
              710       720       730       740       750       760

              950       960       970       980       990      1000
pF1KSD ELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGR
       ::::::::::::::::::::::::::::.:::::::::::::::::::::: ::::.::.
XP_005 ELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGK
              770       780       790       800       810       820

             1010      1020      1030      1040      1050      1060
pF1KSD SHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNV
       .:: ::::.::.::.:::.::::::::::::::::.::::::::::::::::::::::::
XP_005 THIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNV
              830       840       850       860       870       880

             1070      1080      1090      1100      1110      
pF1KSD SSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLNGGPSS 
       .::::::                                                 
XP_005 ASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS
              890       900       910       920       930      

>--
 initn: 283 init1: 283 opt: 283  Z-score: 291.0  bits: 65.4 E(85289): 1.8e-09
Smith-Waterman score: 283; 91.3% identity (95.7% similar) in 46 aa overlap (1068-1113:888-933)

      1040      1050      1060      1070      1080      1090       
pF1KSD PVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVK
                                     :::::::::::.::::::. ::::::::::
XP_005 PVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVK
       860       870       880       890       900       910       

      1100      1110      
pF1KSD VKGKGEMTTYFLNGGPSS 
       ::::::: ::::::::   
XP_005 VKGKGEMMTYFLNGGPPLS
       920       930      

>>XP_011510662 (OMIM: 600293,606703) PREDICTED: adenylat  (923 aa)
 initn: 4146 init1: 1764 opt: 2409  Z-score: 2500.5  bits: 474.2 E(85289): 1.5e-132
Smith-Waterman score: 3782; 70.3% identity (82.2% similar) in 864 aa overlap (287-1067:14-874)

        260       270       280       290       300       310      
pF1KSD MRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTNVIGICTHYPAEVSQRQ
                                     : : .:::.: :::..:.::::::::::::
XP_011                  MLLIRLRDFPSIPKLLVSNVLIFSCTNIVGVCTHYPAEVSQRQ
                                10        20        30        40   

        320       330       340       350       360       370      
pF1KSD AFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHD
       ::::::  :::::: :.::.:::::::::::.::::::: :::.:.::::::::::::::
XP_011 AFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHD
            50        60        70        80        90       100   

        380       390       400       410       420       430      
pF1KSD NVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGL
           110       120       130       140       150       160   

        440       450       460       470       480       490      
pF1KSD PEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWS
       :::::::::::::::.::::::::::::::::::::::::::::::::::::::::::::
XP_011 PEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWS
           170       180       190       200       210       220   

        500       510       520       530       540       550      
pF1KSD NDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQHIETFLILGAS
       :::::::::::::.:::::::.:::.::::::::::: ::::::::::. :::::::  .
XP_011 NDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCT
           230       240       250       260       270       280   

        560       570       580       590           600       610  
pF1KSD QKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSR----TKDSKAFRQMGIDDSSKDNR
       :::::::::.::..: :.::.    :.:  .: :      .. :: ...::..:  :: .
XP_011 QKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDP-KD-K
           290       300       310       320       330        340  

            620       630       640       650       660       670  
pF1KSD GTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAY
       ..:.. ::::::::::.:::::::::.::..:::.:::::.. :::::::..:: :::::
XP_011 NAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAY
             350       360       370       380       390       400 

            680       690       700       710       720       730  
pF1KSD VACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSCGSLFPKALQRLS
       :::: ::: ::::.:. : ::: .::..: .  ::: ..:.. ..::: .:::. :: ::
XP_011 VACASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTLS
             410       420       430       440       450       460 

            740       750       760                                
pF1KSD RSIVRSRAHSTAVGIFSVLLVFTSAIANM-------------------------------
       :.::::. .:: ::.:.. ::: .:..::                               
XP_011 RKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAES
             470       480       490       500       510       520 

                                     770       780       790       
pF1KSD ------------------------YFIGNMLLSLLASSVFLHISSIGKLAMIFVLGLIYL
                               ::  ..:::::: ::::.:: ::::...... ::: 
XP_011 AVNYSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIY-
             530       540       550       560       570       580 

       800       810       820                      830            
pF1KSD VLLLLGPPATIFDNYDLLLGVHGLASSNETFD---------------GLDCPA-------
       ::..  : .:.::: :::. ....   :.  .               :   :.       
XP_011 VLIVEVPGVTLFDNADLLVTANAIDFFNNGTSQWSLCENLRHRRMEAGTYFPSGVKEQSP
              590       600       610       620       630       640

           840       850       860       870       880       890   
pF1KSD --AGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRR
         : .:::: .::.:. ::.::::::::::::::::::::::::: ::::::::::::::
XP_011 EHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRR
              650       660       670       680       690       700

           900       910       920       930       940       950   
pF1KSD LLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLR
              710       720       730       740       750       760

           960       970       980       990      1000      1010   
pF1KSD LLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRL
       :::::::::::::::.:::::::::::::::::::::: ::::.::..:: ::::.::.:
XP_011 LLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKL
              770       780       790       800       810       820

          1020      1030      1040      1050      1060      1070   
pF1KSD MEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRI
       :.:::.::::::::::::::::.::::::::::::::::::::::::.::::::      
XP_011 MDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRI
              830       840       850       860       870       880

          1080      1090      1100      1110      
pF1KSD QVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLNGGPSS 
                                                  
XP_011 QVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS
              890       900       910       920   

>--
 initn: 283 init1: 283 opt: 283  Z-score: 291.1  bits: 65.4 E(85289): 1.8e-09
Smith-Waterman score: 283; 91.3% identity (95.7% similar) in 46 aa overlap (1068-1113:875-920)

      1040      1050      1060      1070      1080      1090       
pF1KSD PVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVK
                                     :::::::::::.::::::. ::::::::::
XP_011 PVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVK
          850       860       870       880       890       900    

      1100      1110      
pF1KSD VKGKGEMTTYFLNGGPSS 
       ::::::: ::::::::   
XP_011 VKGKGEMMTYFLNGGPPLS
          910       920   

>>XP_011510661 (OMIM: 600293,606703) PREDICTED: adenylat  (953 aa)
 initn: 4142 init1: 1760 opt: 2409  Z-score: 2500.3  bits: 474.2 E(85289): 1.6e-132
Smith-Waterman score: 3782; 70.0% identity (82.0% similar) in 870 aa overlap (281-1067:41-904)

              260       270       280       290       300       310
pF1KSD TLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTNVIGICTHYPA
                                     : .: :  : .:::.: :::..:.::::::
XP_011 THTLQTWSPLEKPVCTGQAEHGVEKEKPSGGRSF-W--LVSNVLIFSCTNIVGVCTHYPA
               20        30        40           50        60       

              320       330       340       350       360       370
pF1KSD EVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKI
       ::::::::::::  :::::: :.::.:::::::::::.::::::: :::.:.::::::::
XP_011 EVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKI
        70        80        90       100       110       120       

              380       390       400       410       420       430
pF1KSD YIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCY
       130       140       150       160       170       180       

              440       450       460       470       480       490
pF1KSD YCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKW
       :::::::::::::::::::::.::::::::::::::::::::::::::::::::::::::
XP_011 YCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKW
       190       200       210       220       230       240       

              500       510       520       530       540       550
pF1KSD QFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQHIETF
       :::::::::::::::::::.:::::::.:::.::::::::::: ::::::::::. ::::
XP_011 QFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETF
       250       260       270       280       290       300       

              560       570       580       590           600      
pF1KSD LILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSR----TKDSKAFRQMGIDD
       :::  .:::::::::.::..: :.::.    :.:  .: :      .. :: ...::..:
XP_011 LILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFED
       310       320       330       340       350       360       

        610       620       630       640       650       660      
pF1KSD SSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVD
         :: ...:.. ::::::::::.:::::::::.::..:::.:::::.. :::::::..::
XP_011 P-KD-KNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVD
        370        380       390       400       410       420     

        670       680       690       700       710       720      
pF1KSD PRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSCGSLFPK
        ::::::::: ::: ::::.:. : ::: .::..: .  ::: ..:.. ..::: .:::.
XP_011 DRFGAYVACASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPS
         430       440       450       460       470       480     

        730       740       750       760                          
pF1KSD ALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANM-------------------------
        :: :::.::::. .:: ::.:.. ::: .:..::                         
XP_011 PLQTLSRKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNA
         490       500       510       520       530       540     

                                           770       780       790 
pF1KSD ------------------------------YFIGNMLLSLLASSVFLHISSIGKLAMIFV
                                     ::  ..:::::: ::::.:: ::::.....
XP_011 CHVAESAVNYSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLA
         550       560       570       580       590       600     

             800       810       820                      830      
pF1KSD LGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFD---------------GLDCPA-
       . ::: ::..  : .:.::: :::. ....   :.  .               :   :. 
XP_011 IELIY-VLIVEVPGVTLFDNADLLVTANAIDFFNNGTSQWSLCENLRHRRMEAGTYFPSG
         610        620       630       640       650       660    

                 840       850       860       870       880       
pF1KSD --------AGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEEL
               : .:::: .::.:. ::.::::::::::::::::::::::::: ::::::::
XP_011 VKEQSPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEEL
          670       680       690       700       710       720    

       890       900       910       920       930       940       
pF1KSD QAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNE
          730       740       750       760       770       780    

       950       960       970       980       990      1000       
pF1KSD GVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALA
       :::::::::::::::::::::.:::::::::::::::::::::: ::::.::..:: :::
XP_011 GVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALA
          790       800       810       820       830       840    

      1010      1020      1030      1040      1050      1060       
pF1KSD DYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDST
       :.::.::.:::.::::::::::::::::.::::::::::::::::::::::::.::::::
XP_011 DFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDST
          850       860       870       880       890       900    

      1070      1080      1090      1100      1110      
pF1KSD GVPDRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLNGGPSS 
                                                        
XP_011 GVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS
          910       920       930       940       950   

>--
 initn: 283 init1: 283 opt: 283  Z-score: 290.9  bits: 65.4 E(85289): 1.8e-09
Smith-Waterman score: 283; 91.3% identity (95.7% similar) in 46 aa overlap (1068-1113:905-950)

      1040      1050      1060      1070      1080      1090       
pF1KSD PVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVK
                                     :::::::::::.::::::. ::::::::::
XP_011 PVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVK
          880       890       900       910       920       930    

      1100      1110      
pF1KSD VKGKGEMTTYFLNGGPSS 
       ::::::: ::::::::   
XP_011 VKGKGEMMTYFLNGGPPLS
          940       950   




1115 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 01:40:39 2016 done: Thu Nov  3 01:40:40 2016
 Total Scan time: 10.100 Total Display time:  0.410

Function used was FASTA [36.3.4 Apr, 2011]
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