Result of FASTA (omim) for pF1KSDA0132
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KSDA0132, 624 aa
  1>>>pF1KSDA0132 624 - 624 aa - 624 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.5654+/-0.000429; mu= 17.7707+/- 0.026
 mean_var=79.8382+/-17.332, 0's: 0 Z-trim(109.9): 338  B-trim: 1707 in 2/53
 Lambda= 0.143539
 statistics sampled from 17750 (18150) to 17750 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.571), E-opt: 0.2 (0.213), width:  16
 Scan time: 10.000

The best scores are:                                      opt bits E(85289)
NP_987096 (OMIM: 606016) kelch-like ECH-associated ( 624) 4314 903.9       0
NP_036421 (OMIM: 606016) kelch-like ECH-associated ( 624) 4314 903.9       0
XP_005260231 (OMIM: 606016) PREDICTED: kelch-like  ( 624) 4314 903.9       0
XP_005260230 (OMIM: 606016) PREDICTED: kelch-like  ( 624) 4314 903.9       0
XP_011526754 (OMIM: 606016) PREDICTED: kelch-like  ( 624) 4314 903.9       0
NP_001165125 (OMIM: 608064) kelch-like protein 5 i ( 568) 1262 271.8 4.4e-72
NP_001007076 (OMIM: 608064) kelch-like protein 5 i ( 709) 1262 271.9 5.3e-72
NP_057074 (OMIM: 608064) kelch-like protein 5 isof ( 755) 1262 271.9 5.6e-72
XP_016863764 (OMIM: 608064) PREDICTED: kelch-like  ( 788) 1262 271.9 5.7e-72
XP_005262712 (OMIM: 608064) PREDICTED: kelch-like  ( 789) 1262 271.9 5.8e-72
NP_009177 (OMIM: 605774) kelch-like protein 2 isof ( 593) 1248 269.0 3.4e-71
NP_001154993 (OMIM: 605774) kelch-like protein 2 i ( 597) 1248 269.0 3.4e-71
NP_067646 (OMIM: 614522) kelch-like protein 12 iso ( 568) 1247 268.7 3.8e-71
NP_001289980 (OMIM: 614522) kelch-like protein 12  ( 606) 1247 268.8   4e-71
XP_011508137 (OMIM: 614522) PREDICTED: kelch-like  ( 623) 1247 268.8 4.1e-71
XP_016863163 (OMIM: 605774) PREDICTED: kelch-like  ( 555) 1239 267.1 1.2e-70
XP_016863762 (OMIM: 608064) PREDICTED: kelch-like  ( 804) 1241 267.6 1.2e-70
XP_011512001 (OMIM: 608064) PREDICTED: kelch-like  ( 804) 1241 267.6 1.2e-70
XP_016863763 (OMIM: 608064) PREDICTED: kelch-like  ( 804) 1241 267.6 1.2e-70
XP_011512003 (OMIM: 608064) PREDICTED: kelch-like  ( 788) 1237 266.8 2.1e-70
XP_016863765 (OMIM: 608064) PREDICTED: kelch-like  ( 788) 1237 266.8 2.1e-70
XP_011512002 (OMIM: 608064) PREDICTED: kelch-like  ( 788) 1237 266.8 2.1e-70
NP_065917 (OMIM: 605332) kelch-like protein 1 isof ( 748) 1228 264.9 7.3e-70
XP_016876167 (OMIM: 605332) PREDICTED: kelch-like  ( 575) 1222 263.6 1.4e-69
NP_059111 (OMIM: 605775,614495) kelch-like protein ( 587) 1204 259.8 1.9e-68
NP_950240 (OMIM: 608064) kelch-like protein 5 isof ( 694) 1201 259.3 3.3e-68
NP_001244123 (OMIM: 605775,614495) kelch-like prot ( 555) 1193 257.6 8.7e-68
XP_011529874 (OMIM: 605774) PREDICTED: kelch-like  ( 633) 1189 256.8 1.7e-67
NP_061990 (OMIM: 300348) kelch-like protein 4 isof ( 718) 1188 256.6 2.2e-67
NP_001273654 (OMIM: 605332) kelch-like protein 1 i ( 687) 1162 251.2 8.8e-66
NP_476503 (OMIM: 300348) kelch-like protein 4 isof ( 720) 1160 250.8 1.2e-65
XP_016876168 (OMIM: 605332) PREDICTED: kelch-like  ( 525) 1158 250.3 1.3e-65
NP_065854 (OMIM: 611967) kelch-like protein 8 isof ( 620) 1047 227.4 1.2e-58
NP_001278932 (OMIM: 611967) kelch-like protein 8 i ( 620) 1047 227.4 1.2e-58
NP_001026880 (OMIM: 611119,612943,617055) kelch-li ( 586)  945 206.2 2.6e-52
XP_016867928 (OMIM: 611119,612943,617055) PREDICTE ( 564)  920 201.0 9.2e-51
XP_016857484 (OMIM: 614522) PREDICTED: kelch-like  ( 471)  906 198.1 5.9e-50
XP_011508138 (OMIM: 614522) PREDICTED: kelch-like  ( 526)  906 198.1 6.5e-50
NP_001278935 (OMIM: 611967) kelch-like protein 8 i ( 544)  898 196.5 2.1e-49
NP_061334 (OMIM: 611119,612943,617055) kelch-like  ( 538)  882 193.1 2.1e-48
XP_016863164 (OMIM: 605774) PREDICTED: kelch-like  ( 415)  813 178.8 3.4e-44
XP_005247610 (OMIM: 611295) PREDICTED: kelch-like  ( 600)  800 176.2 2.9e-43
XP_016862149 (OMIM: 611295) PREDICTED: kelch-like  ( 600)  800 176.2 2.9e-43
XP_005247613 (OMIM: 611295) PREDICTED: kelch-like  ( 600)  800 176.2 2.9e-43
XP_016862148 (OMIM: 611295) PREDICTED: kelch-like  ( 600)  800 176.2 2.9e-43
XP_011511240 (OMIM: 611295) PREDICTED: kelch-like  ( 600)  800 176.2 2.9e-43
XP_005247612 (OMIM: 611295) PREDICTED: kelch-like  ( 600)  800 176.2 2.9e-43
XP_005247611 (OMIM: 611295) PREDICTED: kelch-like  ( 600)  800 176.2 2.9e-43
NP_060114 (OMIM: 611295) kelch-like protein 24 [Ho ( 600)  800 176.2 2.9e-43
XP_005247609 (OMIM: 611295) PREDICTED: kelch-like  ( 600)  800 176.2 2.9e-43


>>NP_987096 (OMIM: 606016) kelch-like ECH-associated pro  (624 aa)
 initn: 4314 init1: 4314 opt: 4314  Z-score: 4830.2  bits: 903.9 E(85289):    0
Smith-Waterman score: 4314; 100.0% identity (100.0% similar) in 624 aa overlap (1-624:1-624)

               10        20        30        40        50        60
pF1KSD MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_987 MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_987 KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_987 EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_987 PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_987 CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_987 LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_987 PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_987 IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KSD TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_987 TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KSD TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_987 TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG
              550       560       570       580       590       600

              610       620    
pF1KSD RSGVGVAVTMEPCRKQIDQQNCTC
       ::::::::::::::::::::::::
NP_987 RSGVGVAVTMEPCRKQIDQQNCTC
              610       620    

>>NP_036421 (OMIM: 606016) kelch-like ECH-associated pro  (624 aa)
 initn: 4314 init1: 4314 opt: 4314  Z-score: 4830.2  bits: 903.9 E(85289):    0
Smith-Waterman score: 4314; 100.0% identity (100.0% similar) in 624 aa overlap (1-624:1-624)

               10        20        30        40        50        60
pF1KSD MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KSD TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KSD TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG
              550       560       570       580       590       600

              610       620    
pF1KSD RSGVGVAVTMEPCRKQIDQQNCTC
       ::::::::::::::::::::::::
NP_036 RSGVGVAVTMEPCRKQIDQQNCTC
              610       620    

>>XP_005260231 (OMIM: 606016) PREDICTED: kelch-like ECH-  (624 aa)
 initn: 4314 init1: 4314 opt: 4314  Z-score: 4830.2  bits: 903.9 E(85289):    0
Smith-Waterman score: 4314; 100.0% identity (100.0% similar) in 624 aa overlap (1-624:1-624)

               10        20        30        40        50        60
pF1KSD MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KSD TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KSD TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG
              550       560       570       580       590       600

              610       620    
pF1KSD RSGVGVAVTMEPCRKQIDQQNCTC
       ::::::::::::::::::::::::
XP_005 RSGVGVAVTMEPCRKQIDQQNCTC
              610       620    

>>XP_005260230 (OMIM: 606016) PREDICTED: kelch-like ECH-  (624 aa)
 initn: 4314 init1: 4314 opt: 4314  Z-score: 4830.2  bits: 903.9 E(85289):    0
Smith-Waterman score: 4314; 100.0% identity (100.0% similar) in 624 aa overlap (1-624:1-624)

               10        20        30        40        50        60
pF1KSD MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KSD TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KSD TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG
              550       560       570       580       590       600

              610       620    
pF1KSD RSGVGVAVTMEPCRKQIDQQNCTC
       ::::::::::::::::::::::::
XP_005 RSGVGVAVTMEPCRKQIDQQNCTC
              610       620    

>>XP_011526754 (OMIM: 606016) PREDICTED: kelch-like ECH-  (624 aa)
 initn: 4314 init1: 4314 opt: 4314  Z-score: 4830.2  bits: 903.9 E(85289):    0
Smith-Waterman score: 4314; 100.0% identity (100.0% similar) in 624 aa overlap (1-624:1-624)

               10        20        30        40        50        60
pF1KSD MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KSD TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KSD TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG
              550       560       570       580       590       600

              610       620    
pF1KSD RSGVGVAVTMEPCRKQIDQQNCTC
       ::::::::::::::::::::::::
XP_011 RSGVGVAVTMEPCRKQIDQQNCTC
              610       620    

>>NP_001165125 (OMIM: 608064) kelch-like protein 5 isofo  (568 aa)
 initn: 1539 init1: 820 opt: 1262  Z-score: 1415.1  bits: 271.8 E(85289): 4.4e-72
Smith-Waterman score: 1262; 37.0% identity (67.1% similar) in 560 aa overlap (58-606:14-563)

        30        40        50        60        70        80       
pF1KSD GDAVMYASTECKAEVTPSQHGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQD
                                     .:..:.:  :..    .::::: : .  . 
NP_001                  MEPCTSDEFFQALNHAEQTFKKMENYLRHKQLCDVILVAGDRR
                                10        20        30        40   

        90       100       110       120       130       140       
pF1KSD APAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISM
        ::     :..::.: :  : ::::: .::  .: ...::..:. .  ::..:::. . .
NP_001 IPA-----HRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLEL
                 50        60        70        80        90        

       150       160       170       180       190       200       
pF1KSD GEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYI
        :  .  ... : . :...::.::  ::..:: ::: .:: .::.  ::..::. :..: 
NP_001 KEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYT
      100       110       120       130       140       150        

       210       220       230       240       250       260       
pF1KSD YMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQAL
       . :: :: ...::  :   ... :.. ::.:.  :  ...: ..::..: ::::  .. :
NP_001 MEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKL
      160       170       180       190       200       210        

       270       280       290       300         310       320     
pF1KSD LRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVKI--FEELTLHKPTQVMPCRAPK--
       :  .:   :.:.::  ....  ....: .:.  ...   .. :  ..:    :   :.  
NP_001 LAYIRLPLLAPQFLA-DMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKS
      220       230        240       250       260       270       

            330       340       350       360       370       380  
pF1KSD -VGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNN
        :: :. ..:    .. . .: :.   . :  .:...  :  ..  :.   ::.::::  
NP_001 TVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGR--
       280       290       300       310       320       330       

            390       400       410       420       430       440  
pF1KSD SPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVER
         ::    ....:::: :. ::   :::. :. .::.:..: .:::::  :  . :.:::
NP_001 --DGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVER
           340       350       360       370       380       390   

            450       460       470       480       490       500  
pF1KSD YEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITA
       ..:.  .:..:: : : :  ::::::.  :::::: ::.. :.:.::. :. :.: . . 
NP_001 WDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQ
           400       410       420       430       440       450   

            510       520        530            540       550      
pF1KSD MNTIRSGAGVCVLHNCIYAAGGYDGQ-DQLNS-----VERYDVETETWTFVAPMKHRRSA
       :.  :.:.:: . .. .:: ::.:.  ..:.:     ::::: .:. :: :: :.  :.:
NP_001 MSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDA
           460       470       480       490       500       510   

        560       570       580       590       600       610      
pF1KSD LGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEPCRKQ
       .:. .   ..:..:::::...:..:: :::.:. :..:. .  ::.:. :          
NP_001 VGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL     
           520       530       540       550       560             

        620    
pF1KSD IDQQNCTC

>>NP_001007076 (OMIM: 608064) kelch-like protein 5 isofo  (709 aa)
 initn: 1539 init1: 820 opt: 1262  Z-score: 1413.7  bits: 271.9 E(85289): 5.3e-72
Smith-Waterman score: 1262; 37.0% identity (67.1% similar) in 560 aa overlap (58-606:155-704)

        30        40        50        60        70        80       
pF1KSD GDAVMYASTECKAEVTPSQHGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQD
                                     .:..:.:  :..    .::::: : .  . 
NP_001 SSCRTSNSSQTLSSCHTMEPCTSDEFFQALNHAEQTFKKMENYLRHKQLCDVILVAGDRR
          130       140       150       160       170       180    

        90       100       110       120       130       140       
pF1KSD APAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISM
        ::     :..::.: :  : ::::: .::  .: ...::..:. .  ::..:::. . .
NP_001 IPA-----HRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLEL
               190       200       210       220       230         

       150       160       170       180       190       200       
pF1KSD GEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYI
        :  .  ... : . :...::.::  ::..:: ::: .:: .::.  ::..::. :..: 
NP_001 KEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYT
     240       250       260       270       280       290         

       210       220       230       240       250       260       
pF1KSD YMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQAL
       . :: :: ...::  :   ... :.. ::.:.  :  ...: ..::..: ::::  .. :
NP_001 MEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKL
     300       310       320       330       340       350         

       270       280       290       300         310       320     
pF1KSD LRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVKI--FEELTLHKPTQVMPCRAPK--
       :  .:   :.:.::  ....  ....: .:.  ...   .. :  ..:    :   :.  
NP_001 LAYIRLPLLAPQFLA-DMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKS
     360       370        380       390       400       410        

            330       340       350       360       370       380  
pF1KSD -VGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNN
        :: :. ..:    .. . .: :.   . :  .:...  :  ..  :.   ::.::::  
NP_001 TVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGR--
      420       430       440       450       460       470        

            390       400       410       420       430       440  
pF1KSD SPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVER
         ::    ....:::: :. ::   :::. :. .::.:..: .:::::  :  . :.:::
NP_001 --DGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVER
          480       490       500       510       520       530    

            450       460       470       480       490       500  
pF1KSD YEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITA
       ..:.  .:..:: : : :  ::::::.  :::::: ::.. :.:.::. :. :.: . . 
NP_001 WDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQ
          540       550       560       570       580       590    

            510       520        530            540       550      
pF1KSD MNTIRSGAGVCVLHNCIYAAGGYDGQ-DQLNS-----VERYDVETETWTFVAPMKHRRSA
       :.  :.:.:: . .. .:: ::.:.  ..:.:     ::::: .:. :: :: :.  :.:
NP_001 MSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDA
          600       610       620       630       640       650    

        560       570       580       590       600       610      
pF1KSD LGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEPCRKQ
       .:. .   ..:..:::::...:..:: :::.:. :..:. .  ::.:. :          
NP_001 VGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL     
          660       670       680       690       700              

        620    
pF1KSD IDQQNCTC

>>NP_057074 (OMIM: 608064) kelch-like protein 5 isoform   (755 aa)
 initn: 1539 init1: 820 opt: 1262  Z-score: 1413.3  bits: 271.9 E(85289): 5.6e-72
Smith-Waterman score: 1262; 37.0% identity (67.1% similar) in 560 aa overlap (58-606:201-750)

        30        40        50        60        70        80       
pF1KSD GDAVMYASTECKAEVTPSQHGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQD
                                     .:..:.:  :..    .::::: : .  . 
NP_057 SSCRTSNSSQTLSSCHTMEPCTSDEFFQALNHAEQTFKKMENYLRHKQLCDVILVAGDRR
              180       190       200       210       220       230

        90       100       110       120       130       140       
pF1KSD APAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISM
        ::     :..::.: :  : ::::: .::  .: ...::..:. .  ::..:::. . .
NP_057 IPA-----HRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLEL
                   240       250       260       270       280     

       150       160       170       180       190       200       
pF1KSD GEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYI
        :  .  ... : . :...::.::  ::..:: ::: .:: .::.  ::..::. :..: 
NP_057 KEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYT
         290       300       310       320       330       340     

       210       220       230       240       250       260       
pF1KSD YMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQAL
       . :: :: ...::  :   ... :.. ::.:.  :  ...: ..::..: ::::  .. :
NP_057 MEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKL
         350       360       370       380       390       400     

       270       280       290       300         310       320     
pF1KSD LRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVKI--FEELTLHKPTQVMPCRAPK--
       :  .:   :.:.::  ....  ....: .:.  ...   .. :  ..:    :   :.  
NP_057 LAYIRLPLLAPQFLA-DMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKS
         410       420        430       440       450       460    

            330       340       350       360       370       380  
pF1KSD -VGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNN
        :: :. ..:    .. . .: :.   . :  .:...  :  ..  :.   ::.::::  
NP_057 TVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGR--
          470       480       490       500       510       520    

            390       400       410       420       430       440  
pF1KSD SPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVER
         ::    ....:::: :. ::   :::. :. .::.:..: .:::::  :  . :.:::
NP_057 --DGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVER
              530       540       550       560       570       580

            450       460       470       480       490       500  
pF1KSD YEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITA
       ..:.  .:..:: : : :  ::::::.  :::::: ::.. :.:.::. :. :.: . . 
NP_057 WDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQ
              590       600       610       620       630       640

            510       520        530            540       550      
pF1KSD MNTIRSGAGVCVLHNCIYAAGGYDGQ-DQLNS-----VERYDVETETWTFVAPMKHRRSA
       :.  :.:.:: . .. .:: ::.:.  ..:.:     ::::: .:. :: :: :.  :.:
NP_057 MSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDA
              650       660       670       680       690       700

        560       570       580       590       600       610      
pF1KSD LGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEPCRKQ
       .:. .   ..:..:::::...:..:: :::.:. :..:. .  ::.:. :          
NP_057 VGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL     
              710       720       730       740       750          

        620    
pF1KSD IDQQNCTC

>>XP_016863764 (OMIM: 608064) PREDICTED: kelch-like prot  (788 aa)
 initn: 1539 init1: 820 opt: 1262  Z-score: 1413.0  bits: 271.9 E(85289): 5.7e-72
Smith-Waterman score: 1262; 37.0% identity (67.1% similar) in 560 aa overlap (58-606:234-783)

        30        40        50        60        70        80       
pF1KSD GDAVMYASTECKAEVTPSQHGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQD
                                     .:..:.:  :..    .::::: : .  . 
XP_016 SSCRTSNSSQTLSSCHTMEPCTSDEFFQALNHAEQTFKKMENYLRHKQLCDVILVAGDRR
           210       220       230       240       250       260   

        90       100       110       120       130       140       
pF1KSD APAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISM
        ::     :..::.: :  : ::::: .::  .: ...::..:. .  ::..:::. . .
XP_016 IPA-----HRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLEL
                270       280       290       300       310        

       150       160       170       180       190       200       
pF1KSD GEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYI
        :  .  ... : . :...::.::  ::..:: ::: .:: .::.  ::..::. :..: 
XP_016 KEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYT
      320       330       340       350       360       370        

       210       220       230       240       250       260       
pF1KSD YMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQAL
       . :: :: ...::  :   ... :.. ::.:.  :  ...: ..::..: ::::  .. :
XP_016 MEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKL
      380       390       400       410       420       430        

       270       280       290       300         310       320     
pF1KSD LRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVKI--FEELTLHKPTQVMPCRAPK--
       :  .:   :.:.::  ....  ....: .:.  ...   .. :  ..:    :   :.  
XP_016 LAYIRLPLLAPQFLA-DMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKS
      440       450        460       470       480       490       

            330       340       350       360       370       380  
pF1KSD -VGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNN
        :: :. ..:    .. . .: :.   . :  .:...  :  ..  :.   ::.::::  
XP_016 TVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGR--
       500       510       520       530       540       550       

            390       400       410       420       430       440  
pF1KSD SPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVER
         ::    ....:::: :. ::   :::. :. .::.:..: .:::::  :  . :.:::
XP_016 --DGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVER
           560       570       580       590       600       610   

            450       460       470       480       490       500  
pF1KSD YEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITA
       ..:.  .:..:: : : :  ::::::.  :::::: ::.. :.:.::. :. :.: . . 
XP_016 WDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQ
           620       630       640       650       660       670   

            510       520        530            540       550      
pF1KSD MNTIRSGAGVCVLHNCIYAAGGYDGQ-DQLNS-----VERYDVETETWTFVAPMKHRRSA
       :.  :.:.:: . .. .:: ::.:.  ..:.:     ::::: .:. :: :: :.  :.:
XP_016 MSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDA
           680       690       700       710       720       730   

        560       570       580       590       600       610      
pF1KSD LGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEPCRKQ
       .:. .   ..:..:::::...:..:: :::.:. :..:. .  ::.:. :          
XP_016 VGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL     
           740       750       760       770       780             

        620    
pF1KSD IDQQNCTC

>>XP_005262712 (OMIM: 608064) PREDICTED: kelch-like prot  (789 aa)
 initn: 1539 init1: 820 opt: 1262  Z-score: 1413.0  bits: 271.9 E(85289): 5.8e-72
Smith-Waterman score: 1262; 37.0% identity (67.1% similar) in 560 aa overlap (58-606:235-784)

        30        40        50        60        70        80       
pF1KSD GDAVMYASTECKAEVTPSQHGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQD
                                     .:..:.:  :..    .::::: : .  . 
XP_005 SSCRTSNSSQTLSSCHTMEPCTSDEFFQALNHAEQTFKKMENYLRHKQLCDVILVAGDRR
          210       220       230       240       250       260    

        90       100       110       120       130       140       
pF1KSD APAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISM
        ::     :..::.: :  : ::::: .::  .: ...::..:. .  ::..:::. . .
XP_005 IPA-----HRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLEL
               270       280       290       300       310         

       150       160       170       180       190       200       
pF1KSD GEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYI
        :  .  ... : . :...::.::  ::..:: ::: .:: .::.  ::..::. :..: 
XP_005 KEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYT
     320       330       340       350       360       370         

       210       220       230       240       250       260       
pF1KSD YMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQAL
       . :: :: ...::  :   ... :.. ::.:.  :  ...: ..::..: ::::  .. :
XP_005 MEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKL
     380       390       400       410       420       430         

       270       280       290       300         310       320     
pF1KSD LRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVKI--FEELTLHKPTQVMPCRAPK--
       :  .:   :.:.::  ....  ....: .:.  ...   .. :  ..:    :   :.  
XP_005 LAYIRLPLLAPQFLA-DMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKS
     440       450        460       470       480       490        

            330       340       350       360       370       380  
pF1KSD -VGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNN
        :: :. ..:    .. . .: :.   . :  .:...  :  ..  :.   ::.::::  
XP_005 TVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGR--
      500       510       520       530       540       550        

            390       400       410       420       430       440  
pF1KSD SPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVER
         ::    ....:::: :. ::   :::. :. .::.:..: .:::::  :  . :.:::
XP_005 --DGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVER
          560       570       580       590       600       610    

            450       460       470       480       490       500  
pF1KSD YEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITA
       ..:.  .:..:: : : :  ::::::.  :::::: ::.. :.:.::. :. :.: . . 
XP_005 WDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQ
          620       630       640       650       660       670    

            510       520        530            540       550      
pF1KSD MNTIRSGAGVCVLHNCIYAAGGYDGQ-DQLNS-----VERYDVETETWTFVAPMKHRRSA
       :.  :.:.:: . .. .:: ::.:.  ..:.:     ::::: .:. :: :: :.  :.:
XP_005 MSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDA
          680       690       700       710       720       730    

        560       570       580       590       600       610      
pF1KSD LGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEPCRKQ
       .:. .   ..:..:::::...:..:: :::.:. :..:. .  ::.:. :          
XP_005 VGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL     
          740       750       760       770       780              

        620    
pF1KSD IDQQNCTC




624 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 00:08:55 2016 done: Thu Nov  3 00:08:56 2016
 Total Scan time: 10.000 Total Display time:  0.180

Function used was FASTA [36.3.4 Apr, 2011]
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