Result of FASTA (omim) for pF1KSDA0106
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KSDA0106, 224 aa
  1>>>pF1KSDA0106 224 - 224 aa - 224 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 4.7320+/-0.000333; mu= 16.8258+/- 0.021
 mean_var=56.1730+/-11.340, 0's: 0 Z-trim(113.7): 27  B-trim: 94 in 1/52
 Lambda= 0.171124
 statistics sampled from 23104 (23127) to 23104 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.663), E-opt: 0.2 (0.271), width:  16
 Scan time:  5.470

The best scores are:                                      opt bits E(85289)
NP_004896 (OMIM: 602316) peroxiredoxin-6 [Homo sap ( 224) 1498 377.7 8.7e-105
NP_001189360 (OMIM: 176763) peroxiredoxin-1 [Homo  ( 199)  199 57.0 2.7e-08
NP_859048 (OMIM: 176763) peroxiredoxin-1 [Homo sap ( 199)  199 57.0 2.7e-08
NP_002565 (OMIM: 176763) peroxiredoxin-1 [Homo sap ( 199)  199 57.0 2.7e-08
NP_859047 (OMIM: 176763) peroxiredoxin-1 [Homo sap ( 199)  199 57.0 2.7e-08
NP_005800 (OMIM: 600538) peroxiredoxin-2 [Homo sap ( 198)  189 54.5 1.5e-07
NP_001289201 (OMIM: 604769) thioredoxin-dependent  ( 198)  156 46.3 4.3e-05
NP_006784 (OMIM: 604769) thioredoxin-dependent per ( 256)  156 46.4 5.3e-05
XP_005274495 (OMIM: 300927) PREDICTED: peroxiredox ( 257)  155 46.2 6.3e-05
XP_016884720 (OMIM: 300927) PREDICTED: peroxiredox ( 336)  155 46.2 7.8e-05
NP_006397 (OMIM: 300927) peroxiredoxin-4 precursor ( 271)  142 43.0  0.0006
XP_016884719 (OMIM: 300927) PREDICTED: peroxiredox ( 350)  142 43.0 0.00074


>>NP_004896 (OMIM: 602316) peroxiredoxin-6 [Homo sapiens  (224 aa)
 initn: 1498 init1: 1498 opt: 1498  Z-score: 2002.3  bits: 377.7 E(85289): 8.7e-105
Smith-Waterman score: 1498; 100.0% identity (100.0% similar) in 224 aa overlap (1-224:1-224)

               10        20        30        40        50        60
pF1KSD MPGGLLLGDVAPNFEANTTVGRIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MPGGLLLGDVAPNFEANTTVGRIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD FAKRNVKLIALSIDSVEDHLAWSKDINAYNCEEPTEKLPFPIIDDRNRELAILLGMLDPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 FAKRNVKLIALSIDSVEDHLAWSKDINAYNCEEPTEKLPFPIIDDRNRELAILLGMLDPA
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD EKDEKGMPVTARVVFVFGPDKKLKLSILYPATTGRNFDEILRVVISLQLTAEKRVATPVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EKDEKGMPVTARVVFVFGPDKKLKLSILYPATTGRNFDEILRVVISLQLTAEKRVATPVD
              130       140       150       160       170       180

              190       200       210       220    
pF1KSD WKDGDSVMVLPTIPEEEAKKLFPKGVFTKELPSGKKYLRYTPQP
       ::::::::::::::::::::::::::::::::::::::::::::
NP_004 WKDGDSVMVLPTIPEEEAKKLFPKGVFTKELPSGKKYLRYTPQP
              190       200       210       220    

>>NP_001189360 (OMIM: 176763) peroxiredoxin-1 [Homo sapi  (199 aa)
 initn: 245 init1: 132 opt: 199  Z-score: 269.8  bits: 57.0 E(85289): 2.7e-08
Smith-Waterman score: 286; 30.6% identity (59.7% similar) in 206 aa overlap (3-204:4-197)

                10        20         30           40        50     
pF1KSD  MPGGLLLGDVAPNFEANTTVGRIRFHDF-LGDSWG---ILFSHPRDFTPVCTTELGRAA
          :.  .:  ::::.:....   .:.:. :.:  :   ..: .: ::: :: ::.   .
NP_001 MSSGNAKIGHPAPNFKATAVMPDGQFKDISLSDYKGKYVVFFFYPLDFTFVCPTEIIAFS
               10        20        30        40        50        60

          60        70        80        90       100       110     
pF1KSD KLAPEFAKRNVKLIALSIDSVEDHLAWSKDINAYNCEEPTEKLPFPIIDDRNRELAILLG
         : :: : : ..:. :.::   ::::   .:. . .     . .:...: .: .:   :
NP_001 DRAEEFKKLNCQVIGASVDSHFCHLAW---VNTPKKQGGLGPMNIPLVSDPKRTIAQDYG
               70        80           90       100       110       

         120       130       140       150       160       170     
pF1KSD MLDPAEKDEKGMPVTARVVFVFGPDKKLKLSILYPATTGRNFDEILRVVISLQLTAEKRV
       .:    : ..:  .. : .:..     :.   .    .::. :: ::.: ..:.: ..  
NP_001 VL----KADEG--ISFRGLFIIDDKGILRQITVNDLPVGRSVDETLRLVQAFQFTDKHGE
           120         130       140       150       160       170 

         180       190       200       210       220    
pF1KSD ATPVDWKDGDSVMVLPTIPEEEAKKLFPKGVFTKELPSGKKYLRYTPQP
       . :. :: :... . : .  ...:. : :                    
NP_001 VCPAGWKPGSDT-IKPDV--QKSKEYFSKQK                  
             180          190                           

>>NP_859048 (OMIM: 176763) peroxiredoxin-1 [Homo sapiens  (199 aa)
 initn: 245 init1: 132 opt: 199  Z-score: 269.8  bits: 57.0 E(85289): 2.7e-08
Smith-Waterman score: 286; 30.6% identity (59.7% similar) in 206 aa overlap (3-204:4-197)

                10        20         30           40        50     
pF1KSD  MPGGLLLGDVAPNFEANTTVGRIRFHDF-LGDSWG---ILFSHPRDFTPVCTTELGRAA
          :.  .:  ::::.:....   .:.:. :.:  :   ..: .: ::: :: ::.   .
NP_859 MSSGNAKIGHPAPNFKATAVMPDGQFKDISLSDYKGKYVVFFFYPLDFTFVCPTEIIAFS
               10        20        30        40        50        60

          60        70        80        90       100       110     
pF1KSD KLAPEFAKRNVKLIALSIDSVEDHLAWSKDINAYNCEEPTEKLPFPIIDDRNRELAILLG
         : :: : : ..:. :.::   ::::   .:. . .     . .:...: .: .:   :
NP_859 DRAEEFKKLNCQVIGASVDSHFCHLAW---VNTPKKQGGLGPMNIPLVSDPKRTIAQDYG
               70        80           90       100       110       

         120       130       140       150       160       170     
pF1KSD MLDPAEKDEKGMPVTARVVFVFGPDKKLKLSILYPATTGRNFDEILRVVISLQLTAEKRV
       .:    : ..:  .. : .:..     :.   .    .::. :: ::.: ..:.: ..  
NP_859 VL----KADEG--ISFRGLFIIDDKGILRQITVNDLPVGRSVDETLRLVQAFQFTDKHGE
           120         130       140       150       160       170 

         180       190       200       210       220    
pF1KSD ATPVDWKDGDSVMVLPTIPEEEAKKLFPKGVFTKELPSGKKYLRYTPQP
       . :. :: :... . : .  ...:. : :                    
NP_859 VCPAGWKPGSDT-IKPDV--QKSKEYFSKQK                  
             180          190                           

>>NP_002565 (OMIM: 176763) peroxiredoxin-1 [Homo sapiens  (199 aa)
 initn: 245 init1: 132 opt: 199  Z-score: 269.8  bits: 57.0 E(85289): 2.7e-08
Smith-Waterman score: 286; 30.6% identity (59.7% similar) in 206 aa overlap (3-204:4-197)

                10        20         30           40        50     
pF1KSD  MPGGLLLGDVAPNFEANTTVGRIRFHDF-LGDSWG---ILFSHPRDFTPVCTTELGRAA
          :.  .:  ::::.:....   .:.:. :.:  :   ..: .: ::: :: ::.   .
NP_002 MSSGNAKIGHPAPNFKATAVMPDGQFKDISLSDYKGKYVVFFFYPLDFTFVCPTEIIAFS
               10        20        30        40        50        60

          60        70        80        90       100       110     
pF1KSD KLAPEFAKRNVKLIALSIDSVEDHLAWSKDINAYNCEEPTEKLPFPIIDDRNRELAILLG
         : :: : : ..:. :.::   ::::   .:. . .     . .:...: .: .:   :
NP_002 DRAEEFKKLNCQVIGASVDSHFCHLAW---VNTPKKQGGLGPMNIPLVSDPKRTIAQDYG
               70        80           90       100       110       

         120       130       140       150       160       170     
pF1KSD MLDPAEKDEKGMPVTARVVFVFGPDKKLKLSILYPATTGRNFDEILRVVISLQLTAEKRV
       .:    : ..:  .. : .:..     :.   .    .::. :: ::.: ..:.: ..  
NP_002 VL----KADEG--ISFRGLFIIDDKGILRQITVNDLPVGRSVDETLRLVQAFQFTDKHGE
           120         130       140       150       160       170 

         180       190       200       210       220    
pF1KSD ATPVDWKDGDSVMVLPTIPEEEAKKLFPKGVFTKELPSGKKYLRYTPQP
       . :. :: :... . : .  ...:. : :                    
NP_002 VCPAGWKPGSDT-IKPDV--QKSKEYFSKQK                  
             180          190                           

>>NP_859047 (OMIM: 176763) peroxiredoxin-1 [Homo sapiens  (199 aa)
 initn: 245 init1: 132 opt: 199  Z-score: 269.8  bits: 57.0 E(85289): 2.7e-08
Smith-Waterman score: 286; 30.6% identity (59.7% similar) in 206 aa overlap (3-204:4-197)

                10        20         30           40        50     
pF1KSD  MPGGLLLGDVAPNFEANTTVGRIRFHDF-LGDSWG---ILFSHPRDFTPVCTTELGRAA
          :.  .:  ::::.:....   .:.:. :.:  :   ..: .: ::: :: ::.   .
NP_859 MSSGNAKIGHPAPNFKATAVMPDGQFKDISLSDYKGKYVVFFFYPLDFTFVCPTEIIAFS
               10        20        30        40        50        60

          60        70        80        90       100       110     
pF1KSD KLAPEFAKRNVKLIALSIDSVEDHLAWSKDINAYNCEEPTEKLPFPIIDDRNRELAILLG
         : :: : : ..:. :.::   ::::   .:. . .     . .:...: .: .:   :
NP_859 DRAEEFKKLNCQVIGASVDSHFCHLAW---VNTPKKQGGLGPMNIPLVSDPKRTIAQDYG
               70        80           90       100       110       

         120       130       140       150       160       170     
pF1KSD MLDPAEKDEKGMPVTARVVFVFGPDKKLKLSILYPATTGRNFDEILRVVISLQLTAEKRV
       .:    : ..:  .. : .:..     :.   .    .::. :: ::.: ..:.: ..  
NP_859 VL----KADEG--ISFRGLFIIDDKGILRQITVNDLPVGRSVDETLRLVQAFQFTDKHGE
           120         130       140       150       160       170 

         180       190       200       210       220    
pF1KSD ATPVDWKDGDSVMVLPTIPEEEAKKLFPKGVFTKELPSGKKYLRYTPQP
       . :. :: :... . : .  ...:. : :                    
NP_859 VCPAGWKPGSDT-IKPDV--QKSKEYFSKQK                  
             180          190                           

>>NP_005800 (OMIM: 600538) peroxiredoxin-2 [Homo sapiens  (198 aa)
 initn: 206 init1: 128 opt: 189  Z-score: 256.5  bits: 54.5 E(85289): 1.5e-07
Smith-Waterman score: 280; 30.1% identity (60.2% similar) in 206 aa overlap (3-204:4-196)

                10        20            30        40        50     
pF1KSD  MPGGLLLGDVAPNFEANTTVG----RIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAA
          :.  .:  ::.:.:...:     .... :. : .. .:: .: ::: :: ::.   .
NP_005 MASGNARIGKPAPDFKATAVVDGAFKEVKLSDYKG-KYVVLFFYPLDFTFVCPTEIIAFS
               10        20        30         40        50         

          60        70        80        90       100       110     
pF1KSD KLAPEFAKRNVKLIALSIDSVEDHLAWSKDINAYNCEEPTEKLPFPIIDDRNRELAILLG
       . : .: : . .....:.::   ::::   ::.   :     : .:.. : .:.:.   :
NP_005 NRAEDFRKLGCEVLGVSVDSQFTHLAW---INTPRKEGGLGPLNIPLLADVTRRLSEDYG
      60        70        80           90       100       110      

         120       130       140       150       160       170     
pF1KSD MLDPAEKDEKGMPVTARVVFVFGPDKKLKLSILYPATTGRNFDEILRVVISLQLTAEKRV
       .:    : ..:  .. : .:..     :.   .    .::. :: ::.: ..: : :.  
NP_005 VL----KTDEG--IAYRGLFIIDGKGVLRQITVNDLPVGRSVDEALRLVQAFQYTDEHGE
            120         130       140       150       160       170

         180       190       200       210       220    
pF1KSD ATPVDWKDGDSVMVLPTIPEEEAKKLFPKGVFTKELPSGKKYLRYTPQP
       . :. :: :... . :..  ...:. : :                    
NP_005 VCPAGWKPGSDT-IKPNV--DDSKEYFSKHN                  
              180          190                          

>>NP_001289201 (OMIM: 604769) thioredoxin-dependent pero  (198 aa)
 initn: 137 init1: 137 opt: 156  Z-score: 212.5  bits: 46.3 E(85289): 4.3e-05
Smith-Waterman score: 156; 31.5% identity (63.1% similar) in 111 aa overlap (11-117:69-175)

                                   10        20            30      
pF1KSD                     MPGGLLLGDVAPNFEANTTV-GRIR---FHDFLGDSWGIL
                                     :: :.....: :...   . :: : .. .:
NP_001 SLTNLLCSGSSQAKLFSTSSSCHAPAVTQHAPYFKGTAVVNGEFKDLSLDDFKG-KYLVL
       40        50        60        70        80        90        

         40        50        60        70        80        90      
pF1KSD FSHPRDFTPVCTTELGRAAKLAPEFAKRNVKLIALSIDSVEDHLAWSKDINAYNCEEPTE
       : .: ::: :: ::.   .  : ::   : ...:.:.::  .::::   ::.   .    
NP_001 FFYPLDFTFVCPTEIVAFSDKANEFHDVNCEVVAVSVDSHFSHLAW---INTPRKNGGLG
       100       110       120       130       140          150    

        100       110       120       130       140       150      
pF1KSD KLPFPIIDDRNRELAILLGMLDPAEKDEKGMPVTARVVFVFGPDKKLKLSILYPATTGRN
       .. . ...: .....   :.:                                       
NP_001 HMNIALLSDLTKQISRDYGVLLEGSGLALRSSQVQLLPKSTFRR                
          160       170       180       190                        

>>NP_006784 (OMIM: 604769) thioredoxin-dependent peroxid  (256 aa)
 initn: 169 init1: 137 opt: 156  Z-score: 210.9  bits: 46.4 E(85289): 5.3e-05
Smith-Waterman score: 226; 28.3% identity (58.1% similar) in 198 aa overlap (11-204:69-253)

                                   10        20            30      
pF1KSD                     MPGGLLLGDVAPNFEANTTV-GRIR---FHDFLGDSWGIL
                                     :: :.....: :...   . :: : .. .:
NP_006 SLTNLLCSGSSQAKLFSTSSSCHAPAVTQHAPYFKGTAVVNGEFKDLSLDDFKG-KYLVL
       40        50        60        70        80        90        

         40        50        60        70        80        90      
pF1KSD FSHPRDFTPVCTTELGRAAKLAPEFAKRNVKLIALSIDSVEDHLAWSKDINAYNCEEPTE
       : .: ::: :: ::.   .  : ::   : ...:.:.::  .::::   ::.   .    
NP_006 FFYPLDFTFVCPTEIVAFSDKANEFHDVNCEVVAVSVDSHFSHLAW---INTPRKNGGLG
       100       110       120       130       140          150    

        100       110       120       130       140       150      
pF1KSD KLPFPIIDDRNRELAILLGMLDPAEKDEKGMPVTARVVFVFGPDKKLKLSILYPATTGRN
       .. . ...: .....   :.:       .:  .. : .:.. :.  .:   .    .::.
NP_006 HMNIALLSDLTKQISRDYGVL------LEGSGLALRGLFIIDPNGVIKHLSVNDLPVGRS
          160       170             180       190       200        

        160       170       180       190       200       210      
pF1KSD FDEILRVVISLQLTAEKRVATPVDWKDGDSVMVLPTIPEEEAKKLFPKGVFTKELPSGKK
        .: ::.: ..: .  .  . :..:   ::  . :. :   .:. : :            
NP_006 VEETLRLVKAFQYVETHGEVCPANWTP-DSPTIKPS-PAA-SKEYFQKVNQ         
      210       220       230        240         250               

        220    
pF1KSD YLRYTPQP

>>XP_005274495 (OMIM: 300927) PREDICTED: peroxiredoxin-4  (257 aa)
 initn: 219 init1: 124 opt: 155  Z-score: 209.5  bits: 46.2 E(85289): 6.3e-05
Smith-Waterman score: 235; 26.8% identity (57.4% similar) in 209 aa overlap (1-204:61-255)

                                             10        20          
pF1KSD                               MPGGLLLGDVAPNFEANTTVG----RIRFH
                                     .: .....  :: .:.....     .... 
XP_005 VQQEAREGEDWEREPPRQRPPIYEPPESEELPDNVMVSKPAPYWEGTAVIDGEFKELKLT
               40        50        60        70        80        90

         30        40        50        60        70        80      
pF1KSD DFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPEFAKRNVKLIALSIDSVEDHLAWSKDI
       :. : .. ..: .: ::: :: ::.   .    :: . :....: :.::   ::::   :
XP_005 DYRG-KYLVFFFYPLDFTFVCPTEIIAFGDRLEEFRSINTEVVACSVDSQFTHLAW---I
               100       110       120       130       140         

         90       100       110       120       130       140      
pF1KSD NAYNCEEPTEKLPFPIIDDRNRELAILLGMLDPAEKDEKGMPVTARVVFVFGPDKKLKLS
       :.   .     . .:...: .....   :.      ...:   : : .:..     :.  
XP_005 NTPRRQGGLGPIRIPLLSDLTHQISKDYGVY----LEDSGH--TLRGLFIIDDKGILRQI
        150       160       170           180         190       200

        150       160       170       180       190        200     
pF1KSD ILYPATTGRNFDEILRVVISLQLTAEKRVATPVDWKDGDSVMVLPTIPEEEAK-KLFPKG
        :    .::. :: ::.: ..: : ..  . :. :: :. ..    ::.  .: : : : 
XP_005 TLNDLPVGRSVDETLRLVQAFQYTDKHGEVCPAGWKPGSETI----IPDPAGKLKYFDKL
              210       220       230       240           250      

         210       220    
pF1KSD VFTKELPSGKKYLRYTPQP
                          
XP_005 N                  
                          

>>XP_016884720 (OMIM: 300927) PREDICTED: peroxiredoxin-4  (336 aa)
 initn: 214 init1: 124 opt: 155  Z-score: 207.8  bits: 46.2 E(85289): 7.8e-05
Smith-Waterman score: 225; 26.6% identity (58.0% similar) in 188 aa overlap (1-184:61-238)

                                             10        20          
pF1KSD                               MPGGLLLGDVAPNFEANTTVG----RIRFH
                                     .: .....  :: .:.....     .... 
XP_016 VQQEAREGEDWEREPPRQRPPIYEPPESEELPDNVMVSKPAPYWEGTAVIDGEFKELKLT
               40        50        60        70        80        90

         30        40        50        60        70        80      
pF1KSD DFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPEFAKRNVKLIALSIDSVEDHLAWSKDI
       :. : .. ..: .: ::: :: ::.   .    :: . :....: :.::   ::::   :
XP_016 DYRG-KYLVFFFYPLDFTFVCPTEIIAFGDRLEEFRSINTEVVACSVDSQFTHLAW---I
               100       110       120       130       140         

         90       100       110       120       130       140      
pF1KSD NAYNCEEPTEKLPFPIIDDRNRELAILLGMLDPAEKDEKGMPVTARVVFVFGPDKKLKLS
       :.   .     . .:...: .....   :.      ...:   : : .:..     :.  
XP_016 NTPRRQGGLGPIRIPLLSDLTHQISKDYGVY----LEDSGH--TLRGLFIIDDKGILRQI
        150       160       170           180         190       200

        150       160       170       180       190       200      
pF1KSD ILYPATTGRNFDEILRVVISLQLTAEKRVATPVDWKDGDSVMVLPTIPEEEAKKLFPKGV
        :    .::. :: ::.: ..: : ..  . :. :: :                      
XP_016 TLNDLPVGRSVDETLRLVQAFQYTDKHGEVCPAGWKPGSETVSIYICFYVELMVRVEKNA
              210       220       230       240       250       260

        210       220                                              
pF1KSD FTKELPSGKKYLRYTPQP                                          
                                                                   
XP_016 GRAQWLTPVIPALWEAEAGRSRGQEMETILANMVKSVSTKIQKKKISRAWWWVPVVPATR
              270       280       290       300       310       320




224 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 00:00:06 2016 done: Thu Nov  3 00:00:07 2016
 Total Scan time:  5.470 Total Display time:  0.010

Function used was FASTA [36.3.4 Apr, 2011]
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