Result of FASTA (omim) for pF1KSDA0076
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KSDA0076, 1698 aa
  1>>>pF1KSDA0076 1698 - 1698 aa - 1698 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.6287+/-0.000368; mu= 23.5076+/- 0.023
 mean_var=85.1918+/-16.810, 0's: 0 Z-trim(115.2): 73  B-trim: 58 in 1/53
 Lambda= 0.138955
 statistics sampled from 25419 (25492) to 25419 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.646), E-opt: 0.2 (0.299), width:  16
 Scan time: 18.610

The best scores are:                                      opt bits E(85289)
NP_055595 (OMIM: 273750,609577) cullin-7 isoform 2 (1698) 11425 2301.3       0
XP_005249560 (OMIM: 273750,609577) PREDICTED: cull (1750) 11425 2301.3       0
XP_016867028 (OMIM: 273750,609577) PREDICTED: cull (1702) 11407 2297.7       0
XP_011513322 (OMIM: 273750,609577) PREDICTED: cull (1754) 11407 2297.7       0
XP_016867026 (OMIM: 273750,609577) PREDICTED: cull (1730) 10099 2035.5       0
NP_001161842 (OMIM: 273750,609577) cullin-7 isofor (1782) 10099 2035.5       0
XP_006715348 (OMIM: 273750,609577) PREDICTED: cull (1734) 10081 2031.9       0
XP_011513321 (OMIM: 273750,609577) PREDICTED: cull (1786) 10081 2031.9       0
XP_016867023 (OMIM: 273750,609577) PREDICTED: cull (1791) 7889 1592.5       0
XP_016867027 (OMIM: 273750,609577) PREDICTED: cull (1711) 7871 1588.8       0
XP_016867025 (OMIM: 273750,609577) PREDICTED: cull (1743) 7871 1588.8       0
XP_016867024 (OMIM: 273750,609577) PREDICTED: cull (1763) 7871 1588.8       0
XP_016867022 (OMIM: 273750,609577) PREDICTED: cull (1795) 7871 1588.8       0
XP_011513323 (OMIM: 273750,609577) PREDICTED: cull ( 989) 6567 1327.2       0
NP_055904 (OMIM: 607489) cullin-9 [Homo sapiens]   (2517) 3425 697.7 3.5e-199
XP_011512731 (OMIM: 607489) PREDICTED: cullin-9 is (1834) 2833 578.9 1.5e-163
XP_011512730 (OMIM: 607489) PREDICTED: cullin-9 is (1851) 2833 578.9 1.5e-163
XP_016866079 (OMIM: 607489) PREDICTED: cullin-9 is (1909) 2833 578.9 1.5e-163
XP_011512729 (OMIM: 607489) PREDICTED: cullin-9 is (2095) 2833 578.9 1.6e-163
XP_011512728 (OMIM: 607489) PREDICTED: cullin-9 is (2339) 2833 579.0 1.8e-163
XP_011512727 (OMIM: 607489) PREDICTED: cullin-9 is (2456) 2833 579.0 1.8e-163
XP_011512725 (OMIM: 607489) PREDICTED: cullin-9 is (2566) 2833 579.0 1.9e-163
XP_011512724 (OMIM: 607489) PREDICTED: cullin-9 is (2566) 2833 579.0 1.9e-163
XP_016866078 (OMIM: 607489) PREDICTED: cullin-9 is (2566) 2833 579.0 1.9e-163
XP_011512726 (OMIM: 607489) PREDICTED: cullin-9 is (2539) 2807 573.8 6.9e-162
XP_011512732 (OMIM: 607489) PREDICTED: cullin-9 is (1403) 2247 461.3 2.7e-128
XP_016867029 (OMIM: 273750,609577) PREDICTED: cull ( 897) 2220 455.8 8.2e-127
XP_016878186 (OMIM: 176270,227220,605837,615516) P (2556)  324 76.0 4.9e-12
XP_016878187 (OMIM: 176270,227220,605837,615516) P (2556)  324 76.0 4.9e-12
XP_011520435 (OMIM: 176270,227220,605837,615516) P (3749)  324 76.1 6.6e-12
XP_011520433 (OMIM: 176270,227220,605837,615516) P (4673)  324 76.2 7.8e-12
XP_006720790 (OMIM: 176270,227220,605837,615516) P (4748)  324 76.2 7.9e-12
XP_005268333 (OMIM: 176270,227220,605837,615516) P (4796)  324 76.2   8e-12
XP_016878185 (OMIM: 176270,227220,605837,615516) P (4796)  324 76.2   8e-12
XP_016878184 (OMIM: 176270,227220,605837,615516) P (4796)  324 76.2   8e-12
XP_006720789 (OMIM: 176270,227220,605837,615516) P (4829)  324 76.2   8e-12
NP_004658 (OMIM: 176270,227220,605837,615516) E3 u (4834)  324 76.2   8e-12
XP_016868212 (OMIM: 603134) PREDICTED: cullin-1 is ( 455)  186 47.8 0.00027
XP_005250117 (OMIM: 603134) PREDICTED: cullin-1 is ( 776)  186 48.0 0.00041
NP_003583 (OMIM: 603134) cullin-1 [Homo sapiens]   ( 776)  186 48.0 0.00041
XP_011514934 (OMIM: 603134) PREDICTED: cullin-1 is ( 776)  186 48.0 0.00041
XP_011514931 (OMIM: 603134) PREDICTED: cullin-1 is ( 776)  186 48.0 0.00041
XP_011514933 (OMIM: 603134) PREDICTED: cullin-1 is ( 776)  186 48.0 0.00041
XP_011514932 (OMIM: 603134) PREDICTED: cullin-1 is ( 776)  186 48.0 0.00041
NP_055700 (OMIM: 613745) anaphase-promoting comple ( 185)  168 43.9  0.0016
NP_001243636 (OMIM: 613745) anaphase-promoting com ( 185)  168 43.9  0.0016
NP_001243637 (OMIM: 613745) anaphase-promoting com ( 185)  168 43.9  0.0016
NP_001243635 (OMIM: 613745) anaphase-promoting com ( 185)  168 43.9  0.0016
XP_011529826 (OMIM: 613745) PREDICTED: anaphase-pr ( 185)  168 43.9  0.0016
NP_001243638 (OMIM: 613745) anaphase-promoting com ( 196)  168 43.9  0.0017


>>NP_055595 (OMIM: 273750,609577) cullin-7 isoform 2 [Ho  (1698 aa)
 initn: 11425 init1: 11425 opt: 11425  Z-score: 12366.8  bits: 2301.3 E(85289):    0
Smith-Waterman score: 11425; 99.9% identity (100.0% similar) in 1698 aa overlap (1-1698:1-1698)

               10        20        30        40        50        60
pF1KSD MVGELRYREFRVPLGPGLHAYPDELIRQRVGHDGHPEYQIRWLILRRGDEGDGGSGQVDC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MVGELRYREFRVPLGPGLHAYPDELIRQRVGHDGHPEYQIRWLILRRGDEGDGGSGQVDC
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD KAEHILLWMSKDEIYANCHKMLGEDGQVIGPSQESAGEVGALDKSVLEEMETDVKSLIQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KAEHILLWMSKDEIYANCHKMLGEDGQVIGPSQESAGEVGALDKSVLEEMETDVKSLIQR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD ALRQLEECVGTIPPAPLLHTVHVLSAYASIEPLTGVFKDPRVLDLLMHMLSSPDYQIRWS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 ALRQLEECVGTIPPAPLLHTVHVLSAYASIEPLTGVFKDPRVLDLLMHMLSSPDYQIRWS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD AGRMIQALSSHDAGTRTQILLSLSQQEAIEKHLDFDSRCALLALFAQATLSEHPMSFEGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 AGRMIQALSSHDAGTRTQILLSLSQQEAIEKHLDFDSRCALLALFAQATLSEHPMSFEGI
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD QLPQVPGRVLFSLVKRYLHVTSLLDQLNDSAAEPGAQNTSAPEELSGERGQLELEFSMAM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 QLPQVPGRVLFSLVKRYLHVTSLLDQLNDSAAEPGAQNTSAPEELSGERGQLELEFSMAM
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD GTLISELVQAMRWDQASDRPRSSARSPGSIFQPQLADVSPGLPAAQAQPSFRRSRRFRPR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GTLISELVQAMRWDQASDRPRSSARSPGSIFQPQLADVSPGLPAAQAQPSFRRSRRFRPR
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD SEFASGNTYALYVRDTLQPGMRVRMLDDYEEISAGDEGEFRQSNNGVPPVQVFWESTGRT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SEFASGNTYALYVRDTLQPGMRVRMLDDYEEISAGDEGEFRQSNNGVPPVQVFWESTGRT
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD YWVHWHMLEILGFEEDIEDMVEADEYQGAVASRVLGRALPAWRWRPMTELYAVPYVLPED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 YWVHWHMLEILGFEEDIEDMVEADEYQGAVASRVLGRALPAWRWRPMTELYAVPYVLPED
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KSD EDTEECEHLTLAEWWELLFFIKKLDGPDHQEVLQILQENLDGEILDDEILAELAVPIELA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 EDTEECEHLTLAEWWELLFFIKKLDGPDHQEVLQILQENLDGEILDDEILAELAVPIELA
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KSD QDLLLTLPQRLNDSALRDLINCHVYKKYGPEALAGNQAYPSLLEAQEDVLLLDAQAQAKD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 QDLLLTLPQRLNDSALRDLINCHVYKKYGPEALAGNQAYPSLLEAQEDVLLLDAQAQAKD
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KSD SEDAAKVEAKEPPSQSPNTPLQRLVEGYGPAGKILLDLEQALSSEGTQENKVKPLLLQLQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SEDAAKVEAKEPPSQSPNTPLQRLVEGYGPAGKILLDLEQALSSEGTQENKVKPLLLQLQ
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KSD RQPQPFLALMQSLDTPETNRTLHLTVLRILKQLVDFPEALLLPWHEAVDACMACLRSPNT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 RQPQPFLALMQSLDTPETNRTLHLTVLRILKQLVDFPEALLLPWHEAVDACMACLRSPNT
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KSD DREVLQELIFFLHRLTSVSRDYAVVLNQLGARDAISKALEKHLGKLELAQELRDMVFKCE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 DREVLQELIFFLHRLTSVSRDYAVVLNQLGARDAISKALEKHLGKLELAQELRDMVFKCE
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KSD KHAHLYRKLITNILGGCIQMVLGQIEDHRRTHRPINIPFFDVFLRYLCQGSSVEVKEDKC
       ::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::::
NP_055 KHAHLYRKLITNILGGCIQMVLGQIEDHRRTHQPINIPFFDVFLRYLCQGSSVEVKEDKC
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KSD WEKVEVSSNPHRASKLTDHNPKTYWESNGSAGSHYITLHMRRGILIRQLTLLVASEDSSY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 WEKVEVSSNPHRASKLTDHNPKTYWESNGSAGSHYITLHMRRGILIRQLTLLVASEDSSY
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KSD MPARVVVCGGDSTSSLHTELNSVNVMPSASRVILLENLTRFWPIIQIRIKRCQQGGIDTR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MPARVVVCGGDSTSSLHTELNSVNVMPSASRVILLENLTRFWPIIQIRIKRCQQGGIDTR
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KSD IRGLEILGPKPTFWPVFREQLCRHTRLFYMVRAQAWSQDMAEDRRSLLHLSSRLNGALRQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 IRGLEILGPKPTFWPVFREQLCRHTRLFYMVRAQAWSQDMAEDRRSLLHLSSRLNGALRQ
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KSD EQNFADRFLPDDEAAQALGKTCWEALVSPVVQNITSPDEDGISPLGWLLDQYLECQEAVF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 EQNFADRFLPDDEAAQALGKTCWEALVSPVVQNITSPDEDGISPLGWLLDQYLECQEAVF
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KSD NPQSRGPAFFSRVRRLTHLLVHVEPCEAPPPVVATPRPKGRNRSHDWSSLATRGLPSSIM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 NPQSRGPAFFSRVRRLTHLLVHVEPCEAPPPVVATPRPKGRNRSHDWSSLATRGLPSSIM
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KSD RNLTRCWRAVVEKQVNNFLTSSWRDDDFVPRYCEHFNILQNSSSELFGPRAAFLLALQNG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 RNLTRCWRAVVEKQVNNFLTSSWRDDDFVPRYCEHFNILQNSSSELFGPRAAFLLALQNG
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KSD CAGALLKLPFLKAAHVSEQFARHIDQQIQGSRIGGAQEMERLAQLQQCLQAVLIFSGLEI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 CAGALLKLPFLKAAHVSEQFARHIDQQIQGSRIGGAQEMERLAQLQQCLQAVLIFSGLEI
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KSD ATTFEHYYQHYMADRLLGVVSSWLEGAVLEQIGPCFPNRLPQQMLQSLSTSKELQRQFHV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 ATTFEHYYQHYMADRLLGVVSSWLEGAVLEQIGPCFPNRLPQQMLQSLSTSKELQRQFHV
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KSD YQLQQLDQELLKLEDTEKKIQVGLGASGKEHKSEKEEEAGAAAVVDVAEGEEEEEENEDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 YQLQQLDQELLKLEDTEKKIQVGLGASGKEHKSEKEEEAGAAAVVDVAEGEEEEEENEDL
             1330      1340      1350      1360      1370      1380

             1390      1400      1410      1420      1430      1440
pF1KSD YYEGAMPEVSVLVLSRHSWPVASICHTLNPRTCLPSYLRGTLNRYSNFYNKSQSHPALER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 YYEGAMPEVSVLVLSRHSWPVASICHTLNPRTCLPSYLRGTLNRYSNFYNKSQSHPALER
             1390      1400      1410      1420      1430      1440

             1450      1460      1470      1480      1490      1500
pF1KSD GSQRRLQWTWLGWAELQFGNQTLHVSTVQMWLLLYLNDLKAVSVESLLAFSGLSADMLNQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GSQRRLQWTWLGWAELQFGNQTLHVSTVQMWLLLYLNDLKAVSVESLLAFSGLSADMLNQ
             1450      1460      1470      1480      1490      1500

             1510      1520      1530      1540      1550      1560
pF1KSD AIGPLTSSRGPLDLHEQKDIPGGVLKIRDGSKEPRSRWDIVRLIPPQTYLQAEGEDGQNL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 AIGPLTSSRGPLDLHEQKDIPGGVLKIRDGSKEPRSRWDIVRLIPPQTYLQAEGEDGQNL
             1510      1520      1530      1540      1550      1560

             1570      1580      1590      1600      1610      1620
pF1KSD EKRRNLLNCLIVRILKAHGDEGLHIDQLVCLVLEAWQKGPCPPRGLVSSLGKGSACSSTD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 EKRRNLLNCLIVRILKAHGDEGLHIDQLVCLVLEAWQKGPCPPRGLVSSLGKGSACSSTD
             1570      1580      1590      1600      1610      1620

             1630      1640      1650      1660      1670      1680
pF1KSD VLSCILHLLGKGTLRRHDDRPQVLSYAVPVTVMEPHTESLNPGSSGPNPPLTFHTLQIRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 VLSCILHLLGKGTLRRHDDRPQVLSYAVPVTVMEPHTESLNPGSSGPNPPLTFHTLQIRS
             1630      1640      1650      1660      1670      1680

             1690        
pF1KSD RGVPYASCTATQSFSTFR
       ::::::::::::::::::
NP_055 RGVPYASCTATQSFSTFR
             1690        

>>XP_005249560 (OMIM: 273750,609577) PREDICTED: cullin-7  (1750 aa)
 initn: 11425 init1: 11425 opt: 11425  Z-score: 12366.6  bits: 2301.3 E(85289):    0
Smith-Waterman score: 11425; 99.9% identity (100.0% similar) in 1698 aa overlap (1-1698:53-1750)

                                             10        20        30
pF1KSD                               MVGELRYREFRVPLGPGLHAYPDELIRQRV
                                     ::::::::::::::::::::::::::::::
XP_005 ADSRGCSSVPRRHAPSRLSVSTPSRGPGARMVGELRYREFRVPLGPGLHAYPDELIRQRV
             30        40        50        60        70        80  

               40        50        60        70        80        90
pF1KSD GHDGHPEYQIRWLILRRGDEGDGGSGQVDCKAEHILLWMSKDEIYANCHKMLGEDGQVIG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GHDGHPEYQIRWLILRRGDEGDGGSGQVDCKAEHILLWMSKDEIYANCHKMLGEDGQVIG
             90       100       110       120       130       140  

              100       110       120       130       140       150
pF1KSD PSQESAGEVGALDKSVLEEMETDVKSLIQRALRQLEECVGTIPPAPLLHTVHVLSAYASI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PSQESAGEVGALDKSVLEEMETDVKSLIQRALRQLEECVGTIPPAPLLHTVHVLSAYASI
            150       160       170       180       190       200  

              160       170       180       190       200       210
pF1KSD EPLTGVFKDPRVLDLLMHMLSSPDYQIRWSAGRMIQALSSHDAGTRTQILLSLSQQEAIE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EPLTGVFKDPRVLDLLMHMLSSPDYQIRWSAGRMIQALSSHDAGTRTQILLSLSQQEAIE
            210       220       230       240       250       260  

              220       230       240       250       260       270
pF1KSD KHLDFDSRCALLALFAQATLSEHPMSFEGIQLPQVPGRVLFSLVKRYLHVTSLLDQLNDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KHLDFDSRCALLALFAQATLSEHPMSFEGIQLPQVPGRVLFSLVKRYLHVTSLLDQLNDS
            270       280       290       300       310       320  

              280       290       300       310       320       330
pF1KSD AAEPGAQNTSAPEELSGERGQLELEFSMAMGTLISELVQAMRWDQASDRPRSSARSPGSI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAEPGAQNTSAPEELSGERGQLELEFSMAMGTLISELVQAMRWDQASDRPRSSARSPGSI
            330       340       350       360       370       380  

              340       350       360       370       380       390
pF1KSD FQPQLADVSPGLPAAQAQPSFRRSRRFRPRSEFASGNTYALYVRDTLQPGMRVRMLDDYE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FQPQLADVSPGLPAAQAQPSFRRSRRFRPRSEFASGNTYALYVRDTLQPGMRVRMLDDYE
            390       400       410       420       430       440  

              400       410       420       430       440       450
pF1KSD EISAGDEGEFRQSNNGVPPVQVFWESTGRTYWVHWHMLEILGFEEDIEDMVEADEYQGAV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EISAGDEGEFRQSNNGVPPVQVFWESTGRTYWVHWHMLEILGFEEDIEDMVEADEYQGAV
            450       460       470       480       490       500  

              460       470       480       490       500       510
pF1KSD ASRVLGRALPAWRWRPMTELYAVPYVLPEDEDTEECEHLTLAEWWELLFFIKKLDGPDHQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ASRVLGRALPAWRWRPMTELYAVPYVLPEDEDTEECEHLTLAEWWELLFFIKKLDGPDHQ
            510       520       530       540       550       560  

              520       530       540       550       560       570
pF1KSD EVLQILQENLDGEILDDEILAELAVPIELAQDLLLTLPQRLNDSALRDLINCHVYKKYGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EVLQILQENLDGEILDDEILAELAVPIELAQDLLLTLPQRLNDSALRDLINCHVYKKYGP
            570       580       590       600       610       620  

              580       590       600       610       620       630
pF1KSD EALAGNQAYPSLLEAQEDVLLLDAQAQAKDSEDAAKVEAKEPPSQSPNTPLQRLVEGYGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EALAGNQAYPSLLEAQEDVLLLDAQAQAKDSEDAAKVEAKEPPSQSPNTPLQRLVEGYGP
            630       640       650       660       670       680  

              640       650       660       670       680       690
pF1KSD AGKILLDLEQALSSEGTQENKVKPLLLQLQRQPQPFLALMQSLDTPETNRTLHLTVLRIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AGKILLDLEQALSSEGTQENKVKPLLLQLQRQPQPFLALMQSLDTPETNRTLHLTVLRIL
            690       700       710       720       730       740  

              700       710       720       730       740       750
pF1KSD KQLVDFPEALLLPWHEAVDACMACLRSPNTDREVLQELIFFLHRLTSVSRDYAVVLNQLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KQLVDFPEALLLPWHEAVDACMACLRSPNTDREVLQELIFFLHRLTSVSRDYAVVLNQLG
            750       760       770       780       790       800  

              760       770       780       790       800       810
pF1KSD ARDAISKALEKHLGKLELAQELRDMVFKCEKHAHLYRKLITNILGGCIQMVLGQIEDHRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ARDAISKALEKHLGKLELAQELRDMVFKCEKHAHLYRKLITNILGGCIQMVLGQIEDHRR
            810       820       830       840       850       860  

              820       830       840       850       860       870
pF1KSD THRPINIPFFDVFLRYLCQGSSVEVKEDKCWEKVEVSSNPHRASKLTDHNPKTYWESNGS
       ::.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 THQPINIPFFDVFLRYLCQGSSVEVKEDKCWEKVEVSSNPHRASKLTDHNPKTYWESNGS
            870       880       890       900       910       920  

              880       890       900       910       920       930
pF1KSD AGSHYITLHMRRGILIRQLTLLVASEDSSYMPARVVVCGGDSTSSLHTELNSVNVMPSAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AGSHYITLHMRRGILIRQLTLLVASEDSSYMPARVVVCGGDSTSSLHTELNSVNVMPSAS
            930       940       950       960       970       980  

              940       950       960       970       980       990
pF1KSD RVILLENLTRFWPIIQIRIKRCQQGGIDTRIRGLEILGPKPTFWPVFREQLCRHTRLFYM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RVILLENLTRFWPIIQIRIKRCQQGGIDTRIRGLEILGPKPTFWPVFREQLCRHTRLFYM
            990      1000      1010      1020      1030      1040  

             1000      1010      1020      1030      1040      1050
pF1KSD VRAQAWSQDMAEDRRSLLHLSSRLNGALRQEQNFADRFLPDDEAAQALGKTCWEALVSPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VRAQAWSQDMAEDRRSLLHLSSRLNGALRQEQNFADRFLPDDEAAQALGKTCWEALVSPV
           1050      1060      1070      1080      1090      1100  

             1060      1070      1080      1090      1100      1110
pF1KSD VQNITSPDEDGISPLGWLLDQYLECQEAVFNPQSRGPAFFSRVRRLTHLLVHVEPCEAPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VQNITSPDEDGISPLGWLLDQYLECQEAVFNPQSRGPAFFSRVRRLTHLLVHVEPCEAPP
           1110      1120      1130      1140      1150      1160  

             1120      1130      1140      1150      1160      1170
pF1KSD PVVATPRPKGRNRSHDWSSLATRGLPSSIMRNLTRCWRAVVEKQVNNFLTSSWRDDDFVP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PVVATPRPKGRNRSHDWSSLATRGLPSSIMRNLTRCWRAVVEKQVNNFLTSSWRDDDFVP
           1170      1180      1190      1200      1210      1220  

             1180      1190      1200      1210      1220      1230
pF1KSD RYCEHFNILQNSSSELFGPRAAFLLALQNGCAGALLKLPFLKAAHVSEQFARHIDQQIQG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RYCEHFNILQNSSSELFGPRAAFLLALQNGCAGALLKLPFLKAAHVSEQFARHIDQQIQG
           1230      1240      1250      1260      1270      1280  

             1240      1250      1260      1270      1280      1290
pF1KSD SRIGGAQEMERLAQLQQCLQAVLIFSGLEIATTFEHYYQHYMADRLLGVVSSWLEGAVLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SRIGGAQEMERLAQLQQCLQAVLIFSGLEIATTFEHYYQHYMADRLLGVVSSWLEGAVLE
           1290      1300      1310      1320      1330      1340  

             1300      1310      1320      1330      1340      1350
pF1KSD QIGPCFPNRLPQQMLQSLSTSKELQRQFHVYQLQQLDQELLKLEDTEKKIQVGLGASGKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QIGPCFPNRLPQQMLQSLSTSKELQRQFHVYQLQQLDQELLKLEDTEKKIQVGLGASGKE
           1350      1360      1370      1380      1390      1400  

             1360      1370      1380      1390      1400      1410
pF1KSD HKSEKEEEAGAAAVVDVAEGEEEEEENEDLYYEGAMPEVSVLVLSRHSWPVASICHTLNP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HKSEKEEEAGAAAVVDVAEGEEEEEENEDLYYEGAMPEVSVLVLSRHSWPVASICHTLNP
           1410      1420      1430      1440      1450      1460  

             1420      1430      1440      1450      1460      1470
pF1KSD RTCLPSYLRGTLNRYSNFYNKSQSHPALERGSQRRLQWTWLGWAELQFGNQTLHVSTVQM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RTCLPSYLRGTLNRYSNFYNKSQSHPALERGSQRRLQWTWLGWAELQFGNQTLHVSTVQM
           1470      1480      1490      1500      1510      1520  

             1480      1490      1500      1510      1520      1530
pF1KSD WLLLYLNDLKAVSVESLLAFSGLSADMLNQAIGPLTSSRGPLDLHEQKDIPGGVLKIRDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WLLLYLNDLKAVSVESLLAFSGLSADMLNQAIGPLTSSRGPLDLHEQKDIPGGVLKIRDG
           1530      1540      1550      1560      1570      1580  

             1540      1550      1560      1570      1580      1590
pF1KSD SKEPRSRWDIVRLIPPQTYLQAEGEDGQNLEKRRNLLNCLIVRILKAHGDEGLHIDQLVC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SKEPRSRWDIVRLIPPQTYLQAEGEDGQNLEKRRNLLNCLIVRILKAHGDEGLHIDQLVC
           1590      1600      1610      1620      1630      1640  

             1600      1610      1620      1630      1640      1650
pF1KSD LVLEAWQKGPCPPRGLVSSLGKGSACSSTDVLSCILHLLGKGTLRRHDDRPQVLSYAVPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LVLEAWQKGPCPPRGLVSSLGKGSACSSTDVLSCILHLLGKGTLRRHDDRPQVLSYAVPV
           1650      1660      1670      1680      1690      1700  

             1660      1670      1680      1690        
pF1KSD TVMEPHTESLNPGSSGPNPPLTFHTLQIRSRGVPYASCTATQSFSTFR
       ::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TVMEPHTESLNPGSSGPNPPLTFHTLQIRSRGVPYASCTATQSFSTFR
           1710      1720      1730      1740      1750

>>XP_016867028 (OMIM: 273750,609577) PREDICTED: cullin-7  (1702 aa)
 initn: 11452 init1: 10220 opt: 11407  Z-score: 12347.3  bits: 2297.7 E(85289):    0
Smith-Waterman score: 11407; 99.7% identity (99.8% similar) in 1702 aa overlap (1-1698:1-1702)

               10        20        30        40        50        60
pF1KSD MVGELRYREFRVPLGPGLHAYPDELIRQRVGHDGHPEYQIRWLILRRGDEGDGGSGQVDC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MVGELRYREFRVPLGPGLHAYPDELIRQRVGHDGHPEYQIRWLILRRGDEGDGGSGQVDC
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD KAEHILLWMSKDEIYANCHKMLGEDGQVIGPSQESAGEVGALDKSVLEEMETDVKSLIQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KAEHILLWMSKDEIYANCHKMLGEDGQVIGPSQESAGEVGALDKSVLEEMETDVKSLIQR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD ALRQLEECVGTIPPAPLLHTVHVLSAYASIEPLTGVFKDPRVLDLLMHMLSSPDYQIRWS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALRQLEECVGTIPPAPLLHTVHVLSAYASIEPLTGVFKDPRVLDLLMHMLSSPDYQIRWS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD AGRMIQALSSHDAGTRTQILLSLSQQEAIEKHLDFDSRCALLALFAQATLSEHPMSFEGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGRMIQALSSHDAGTRTQILLSLSQQEAIEKHLDFDSRCALLALFAQATLSEHPMSFEGI
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD QLPQVPGRVLFSLVKRYLHVTSLLDQLNDSAAEPGAQNTSAPEELSGERGQLELEFSMAM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLPQVPGRVLFSLVKRYLHVTSLLDQLNDSAAEPGAQNTSAPEELSGERGQLELEFSMAM
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD GTLISELVQAMRWDQASDRPRSSARSPGSIFQPQLADVSPGLPAAQAQPSFRRSRRFRPR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTLISELVQAMRWDQASDRPRSSARSPGSIFQPQLADVSPGLPAAQAQPSFRRSRRFRPR
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD SEFASGNTYALYVRDTLQPGMRVRMLDDYEEISAGDEGEFRQSNNGVPPVQVFWESTGRT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SEFASGNTYALYVRDTLQPGMRVRMLDDYEEISAGDEGEFRQSNNGVPPVQVFWESTGRT
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD YWVHWHMLEILGFEEDIEDMVEADEYQGAVASRVLGRALPAWRWRPMTELYAVPYVLPED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YWVHWHMLEILGFEEDIEDMVEADEYQGAVASRVLGRALPAWRWRPMTELYAVPYVLPED
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KSD EDTEECEHLTLAEWWELLFFIKKLDGPDHQEVLQILQENLDGEILDDEILAELAVPIELA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDTEECEHLTLAEWWELLFFIKKLDGPDHQEVLQILQENLDGEILDDEILAELAVPIELA
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KSD QDLLLTLPQRLNDSALRDLINCHVYKKYGPEALAGNQAYPSLLEAQEDVLLLDAQAQAKD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QDLLLTLPQRLNDSALRDLINCHVYKKYGPEALAGNQAYPSLLEAQEDVLLLDAQAQAKD
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KSD SEDAAKVEAKEPPSQSPNTPLQRLVEGYGPAGKILLDLEQALSSEGTQENKVKPLLLQLQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SEDAAKVEAKEPPSQSPNTPLQRLVEGYGPAGKILLDLEQALSSEGTQENKVKPLLLQLQ
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KSD RQPQPFLALMQSLDTPETNRTLHLTVLRILKQLVDFPEALLLPWHEAVDACMACLRSPNT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQPQPFLALMQSLDTPETNRTLHLTVLRILKQLVDFPEALLLPWHEAVDACMACLRSPNT
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KSD DREVLQELIFFLHRLTSVSRDYAVVLNQLGARDAISKALEKHLGKLELAQELRDMVFKCE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DREVLQELIFFLHRLTSVSRDYAVVLNQLGARDAISKALEKHLGKLELAQELRDMVFKCE
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KSD KHAHLYRKLITNILGGCIQMVLGQIEDHRRTHRPINIPFFDVFLRYLCQGSSVEVKEDKC
       ::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::::
XP_016 KHAHLYRKLITNILGGCIQMVLGQIEDHRRTHQPINIPFFDVFLRYLCQGSSVEVKEDKC
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KSD WEKVEVSSNPHRASKLTDHNPKTYWESNGSAGSHYITLHMRRGILIRQLTLLVASEDSSY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WEKVEVSSNPHRASKLTDHNPKTYWESNGSAGSHYITLHMRRGILIRQLTLLVASEDSSY
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KSD MPARVVVCGGDSTSSLHTELNSVNVMPSASRVILLENLTRFWPIIQIRIKRCQQGGIDTR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MPARVVVCGGDSTSSLHTELNSVNVMPSASRVILLENLTRFWPIIQIRIKRCQQGGIDTR
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KSD IRGLEILGPKPTFWPVFREQLCRHTRLFYMVRAQAWSQDMAEDRRSLLHLSSRLNGALRQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IRGLEILGPKPTFWPVFREQLCRHTRLFYMVRAQAWSQDMAEDRRSLLHLSSRLNGALRQ
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KSD EQNFADRFLPDDEAAQALGKTCWEALVSPVVQNITSPDEDGISPLGWLLDQYLECQEAVF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EQNFADRFLPDDEAAQALGKTCWEALVSPVVQNITSPDEDGISPLGWLLDQYLECQEAVF
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KSD NPQSRGPAFFSRVRRLTHLLVHVEPCEAPPPVVATPRPKGRNRSHDWSSLATRGLPSSIM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NPQSRGPAFFSRVRRLTHLLVHVEPCEAPPPVVATPRPKGRNRSHDWSSLATRGLPSSIM
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KSD RNLTRCWRAVVEKQVNNFLTSSWRDDDFVPRYCEHFNILQNSSSELFGPRAAFLLALQNG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RNLTRCWRAVVEKQVNNFLTSSWRDDDFVPRYCEHFNILQNSSSELFGPRAAFLLALQNG
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KSD CAGALLKLPFLKAAHVSEQFARHIDQQIQGSRIGGAQEMERLAQLQQCLQAVLIFSGLEI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CAGALLKLPFLKAAHVSEQFARHIDQQIQGSRIGGAQEMERLAQLQQCLQAVLIFSGLEI
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KSD ATTFEHYYQHYMADRLLGVVSSWLEGAVLEQIGPCFPNRLPQQMLQSLSTSKELQRQFHV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ATTFEHYYQHYMADRLLGVVSSWLEGAVLEQIGPCFPNRLPQQMLQSLSTSKELQRQFHV
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KSD YQLQQLDQELLKLEDTEKKIQVGLGASGKEHKSEKEEEAGAAAVVDVAEGEEEEEENEDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YQLQQLDQELLKLEDTEKKIQVGLGASGKEHKSEKEEEAGAAAVVDVAEGEEEEEENEDL
             1330      1340      1350      1360      1370      1380

             1390      1400      1410      1420      1430      1440
pF1KSD YYEGAMPEVSVLVLSRHSWPVASICHTLNPRTCLPSYLRGTLNRYSNFYNKSQSHPALER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YYEGAMPEVSVLVLSRHSWPVASICHTLNPRTCLPSYLRGTLNRYSNFYNKSQSHPALER
             1390      1400      1410      1420      1430      1440

             1450      1460      1470      1480      1490      1500
pF1KSD GSQRRLQWTWLGWAELQFGNQTLHVSTVQMWLLLYLNDLKAVSVESLLAFSGLSADMLNQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSQRRLQWTWLGWAELQFGNQTLHVSTVQMWLLLYLNDLKAVSVESLLAFSGLSADMLNQ
             1450      1460      1470      1480      1490      1500

             1510      1520          1530      1540      1550      
pF1KSD AIGPLTSSRGPLDLHEQKDIPG----GVLKIRDGSKEPRSRWDIVRLIPPQTYLQAEGED
       ::::::::::::::::::::::    ::::::::::::::::::::::::::::::::::
XP_016 AIGPLTSSRGPLDLHEQKDIPGAFISGVLKIRDGSKEPRSRWDIVRLIPPQTYLQAEGED
             1510      1520      1530      1540      1550      1560

       1560      1570      1580      1590      1600      1610      
pF1KSD GQNLEKRRNLLNCLIVRILKAHGDEGLHIDQLVCLVLEAWQKGPCPPRGLVSSLGKGSAC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GQNLEKRRNLLNCLIVRILKAHGDEGLHIDQLVCLVLEAWQKGPCPPRGLVSSLGKGSAC
             1570      1580      1590      1600      1610      1620

       1620      1630      1640      1650      1660      1670      
pF1KSD SSTDVLSCILHLLGKGTLRRHDDRPQVLSYAVPVTVMEPHTESLNPGSSGPNPPLTFHTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSTDVLSCILHLLGKGTLRRHDDRPQVLSYAVPVTVMEPHTESLNPGSSGPNPPLTFHTL
             1630      1640      1650      1660      1670      1680

       1680      1690        
pF1KSD QIRSRGVPYASCTATQSFSTFR
       ::::::::::::::::::::::
XP_016 QIRSRGVPYASCTATQSFSTFR
             1690      1700  

>>XP_011513322 (OMIM: 273750,609577) PREDICTED: cullin-7  (1754 aa)
 initn: 11452 init1: 10220 opt: 11407  Z-score: 12347.1  bits: 2297.7 E(85289):    0
Smith-Waterman score: 11407; 99.7% identity (99.8% similar) in 1702 aa overlap (1-1698:53-1754)

                                             10        20        30
pF1KSD                               MVGELRYREFRVPLGPGLHAYPDELIRQRV
                                     ::::::::::::::::::::::::::::::
XP_011 ADSRGCSSVPRRHAPSRLSVSTPSRGPGARMVGELRYREFRVPLGPGLHAYPDELIRQRV
             30        40        50        60        70        80  

               40        50        60        70        80        90
pF1KSD GHDGHPEYQIRWLILRRGDEGDGGSGQVDCKAEHILLWMSKDEIYANCHKMLGEDGQVIG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GHDGHPEYQIRWLILRRGDEGDGGSGQVDCKAEHILLWMSKDEIYANCHKMLGEDGQVIG
             90       100       110       120       130       140  

              100       110       120       130       140       150
pF1KSD PSQESAGEVGALDKSVLEEMETDVKSLIQRALRQLEECVGTIPPAPLLHTVHVLSAYASI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSQESAGEVGALDKSVLEEMETDVKSLIQRALRQLEECVGTIPPAPLLHTVHVLSAYASI
            150       160       170       180       190       200  

              160       170       180       190       200       210
pF1KSD EPLTGVFKDPRVLDLLMHMLSSPDYQIRWSAGRMIQALSSHDAGTRTQILLSLSQQEAIE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EPLTGVFKDPRVLDLLMHMLSSPDYQIRWSAGRMIQALSSHDAGTRTQILLSLSQQEAIE
            210       220       230       240       250       260  

              220       230       240       250       260       270
pF1KSD KHLDFDSRCALLALFAQATLSEHPMSFEGIQLPQVPGRVLFSLVKRYLHVTSLLDQLNDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KHLDFDSRCALLALFAQATLSEHPMSFEGIQLPQVPGRVLFSLVKRYLHVTSLLDQLNDS
            270       280       290       300       310       320  

              280       290       300       310       320       330
pF1KSD AAEPGAQNTSAPEELSGERGQLELEFSMAMGTLISELVQAMRWDQASDRPRSSARSPGSI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAEPGAQNTSAPEELSGERGQLELEFSMAMGTLISELVQAMRWDQASDRPRSSARSPGSI
            330       340       350       360       370       380  

              340       350       360       370       380       390
pF1KSD FQPQLADVSPGLPAAQAQPSFRRSRRFRPRSEFASGNTYALYVRDTLQPGMRVRMLDDYE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FQPQLADVSPGLPAAQAQPSFRRSRRFRPRSEFASGNTYALYVRDTLQPGMRVRMLDDYE
            390       400       410       420       430       440  

              400       410       420       430       440       450
pF1KSD EISAGDEGEFRQSNNGVPPVQVFWESTGRTYWVHWHMLEILGFEEDIEDMVEADEYQGAV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EISAGDEGEFRQSNNGVPPVQVFWESTGRTYWVHWHMLEILGFEEDIEDMVEADEYQGAV
            450       460       470       480       490       500  

              460       470       480       490       500       510
pF1KSD ASRVLGRALPAWRWRPMTELYAVPYVLPEDEDTEECEHLTLAEWWELLFFIKKLDGPDHQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASRVLGRALPAWRWRPMTELYAVPYVLPEDEDTEECEHLTLAEWWELLFFIKKLDGPDHQ
            510       520       530       540       550       560  

              520       530       540       550       560       570
pF1KSD EVLQILQENLDGEILDDEILAELAVPIELAQDLLLTLPQRLNDSALRDLINCHVYKKYGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EVLQILQENLDGEILDDEILAELAVPIELAQDLLLTLPQRLNDSALRDLINCHVYKKYGP
            570       580       590       600       610       620  

              580       590       600       610       620       630
pF1KSD EALAGNQAYPSLLEAQEDVLLLDAQAQAKDSEDAAKVEAKEPPSQSPNTPLQRLVEGYGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EALAGNQAYPSLLEAQEDVLLLDAQAQAKDSEDAAKVEAKEPPSQSPNTPLQRLVEGYGP
            630       640       650       660       670       680  

              640       650       660       670       680       690
pF1KSD AGKILLDLEQALSSEGTQENKVKPLLLQLQRQPQPFLALMQSLDTPETNRTLHLTVLRIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGKILLDLEQALSSEGTQENKVKPLLLQLQRQPQPFLALMQSLDTPETNRTLHLTVLRIL
            690       700       710       720       730       740  

              700       710       720       730       740       750
pF1KSD KQLVDFPEALLLPWHEAVDACMACLRSPNTDREVLQELIFFLHRLTSVSRDYAVVLNQLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KQLVDFPEALLLPWHEAVDACMACLRSPNTDREVLQELIFFLHRLTSVSRDYAVVLNQLG
            750       760       770       780       790       800  

              760       770       780       790       800       810
pF1KSD ARDAISKALEKHLGKLELAQELRDMVFKCEKHAHLYRKLITNILGGCIQMVLGQIEDHRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ARDAISKALEKHLGKLELAQELRDMVFKCEKHAHLYRKLITNILGGCIQMVLGQIEDHRR
            810       820       830       840       850       860  

              820       830       840       850       860       870
pF1KSD THRPINIPFFDVFLRYLCQGSSVEVKEDKCWEKVEVSSNPHRASKLTDHNPKTYWESNGS
       ::.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 THQPINIPFFDVFLRYLCQGSSVEVKEDKCWEKVEVSSNPHRASKLTDHNPKTYWESNGS
            870       880       890       900       910       920  

              880       890       900       910       920       930
pF1KSD AGSHYITLHMRRGILIRQLTLLVASEDSSYMPARVVVCGGDSTSSLHTELNSVNVMPSAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGSHYITLHMRRGILIRQLTLLVASEDSSYMPARVVVCGGDSTSSLHTELNSVNVMPSAS
            930       940       950       960       970       980  

              940       950       960       970       980       990
pF1KSD RVILLENLTRFWPIIQIRIKRCQQGGIDTRIRGLEILGPKPTFWPVFREQLCRHTRLFYM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RVILLENLTRFWPIIQIRIKRCQQGGIDTRIRGLEILGPKPTFWPVFREQLCRHTRLFYM
            990      1000      1010      1020      1030      1040  

             1000      1010      1020      1030      1040      1050
pF1KSD VRAQAWSQDMAEDRRSLLHLSSRLNGALRQEQNFADRFLPDDEAAQALGKTCWEALVSPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VRAQAWSQDMAEDRRSLLHLSSRLNGALRQEQNFADRFLPDDEAAQALGKTCWEALVSPV
           1050      1060      1070      1080      1090      1100  

             1060      1070      1080      1090      1100      1110
pF1KSD VQNITSPDEDGISPLGWLLDQYLECQEAVFNPQSRGPAFFSRVRRLTHLLVHVEPCEAPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VQNITSPDEDGISPLGWLLDQYLECQEAVFNPQSRGPAFFSRVRRLTHLLVHVEPCEAPP
           1110      1120      1130      1140      1150      1160  

             1120      1130      1140      1150      1160      1170
pF1KSD PVVATPRPKGRNRSHDWSSLATRGLPSSIMRNLTRCWRAVVEKQVNNFLTSSWRDDDFVP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PVVATPRPKGRNRSHDWSSLATRGLPSSIMRNLTRCWRAVVEKQVNNFLTSSWRDDDFVP
           1170      1180      1190      1200      1210      1220  

             1180      1190      1200      1210      1220      1230
pF1KSD RYCEHFNILQNSSSELFGPRAAFLLALQNGCAGALLKLPFLKAAHVSEQFARHIDQQIQG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RYCEHFNILQNSSSELFGPRAAFLLALQNGCAGALLKLPFLKAAHVSEQFARHIDQQIQG
           1230      1240      1250      1260      1270      1280  

             1240      1250      1260      1270      1280      1290
pF1KSD SRIGGAQEMERLAQLQQCLQAVLIFSGLEIATTFEHYYQHYMADRLLGVVSSWLEGAVLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SRIGGAQEMERLAQLQQCLQAVLIFSGLEIATTFEHYYQHYMADRLLGVVSSWLEGAVLE
           1290      1300      1310      1320      1330      1340  

             1300      1310      1320      1330      1340      1350
pF1KSD QIGPCFPNRLPQQMLQSLSTSKELQRQFHVYQLQQLDQELLKLEDTEKKIQVGLGASGKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QIGPCFPNRLPQQMLQSLSTSKELQRQFHVYQLQQLDQELLKLEDTEKKIQVGLGASGKE
           1350      1360      1370      1380      1390      1400  

             1360      1370      1380      1390      1400      1410
pF1KSD HKSEKEEEAGAAAVVDVAEGEEEEEENEDLYYEGAMPEVSVLVLSRHSWPVASICHTLNP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HKSEKEEEAGAAAVVDVAEGEEEEEENEDLYYEGAMPEVSVLVLSRHSWPVASICHTLNP
           1410      1420      1430      1440      1450      1460  

             1420      1430      1440      1450      1460      1470
pF1KSD RTCLPSYLRGTLNRYSNFYNKSQSHPALERGSQRRLQWTWLGWAELQFGNQTLHVSTVQM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTCLPSYLRGTLNRYSNFYNKSQSHPALERGSQRRLQWTWLGWAELQFGNQTLHVSTVQM
           1470      1480      1490      1500      1510      1520  

             1480      1490      1500      1510      1520          
pF1KSD WLLLYLNDLKAVSVESLLAFSGLSADMLNQAIGPLTSSRGPLDLHEQKDIPG----GVLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::    ::::
XP_011 WLLLYLNDLKAVSVESLLAFSGLSADMLNQAIGPLTSSRGPLDLHEQKDIPGAFISGVLK
           1530      1540      1550      1560      1570      1580  

       1530      1540      1550      1560      1570      1580      
pF1KSD IRDGSKEPRSRWDIVRLIPPQTYLQAEGEDGQNLEKRRNLLNCLIVRILKAHGDEGLHID
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IRDGSKEPRSRWDIVRLIPPQTYLQAEGEDGQNLEKRRNLLNCLIVRILKAHGDEGLHID
           1590      1600      1610      1620      1630      1640  

       1590      1600      1610      1620      1630      1640      
pF1KSD QLVCLVLEAWQKGPCPPRGLVSSLGKGSACSSTDVLSCILHLLGKGTLRRHDDRPQVLSY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QLVCLVLEAWQKGPCPPRGLVSSLGKGSACSSTDVLSCILHLLGKGTLRRHDDRPQVLSY
           1650      1660      1670      1680      1690      1700  

       1650      1660      1670      1680      1690        
pF1KSD AVPVTVMEPHTESLNPGSSGPNPPLTFHTLQIRSRGVPYASCTATQSFSTFR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVPVTVMEPHTESLNPGSSGPNPPLTFHTLQIRSRGVPYASCTATQSFSTFR
           1710      1720      1730      1740      1750    

>>XP_016867026 (OMIM: 273750,609577) PREDICTED: cullin-7  (1730 aa)
 initn: 11411 init1: 10099 opt: 10099  Z-score: 10930.0  bits: 2035.5 E(85289):    0
Smith-Waterman score: 11351; 98.1% identity (98.2% similar) in 1730 aa overlap (1-1698:1-1730)

               10        20        30        40        50        60
pF1KSD MVGELRYREFRVPLGPGLHAYPDELIRQRVGHDGHPEYQIRWLILRRGDEGDGGSGQVDC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MVGELRYREFRVPLGPGLHAYPDELIRQRVGHDGHPEYQIRWLILRRGDEGDGGSGQVDC
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD KAEHILLWMSKDEIYANCHKMLGEDGQVIGPSQESAGEVGALDKSVLEEMETDVKSLIQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KAEHILLWMSKDEIYANCHKMLGEDGQVIGPSQESAGEVGALDKSVLEEMETDVKSLIQR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD ALRQLEECVGTIPPAPLLHTVHVLSAYASIEPLTGVFKDPRVLDLLMHMLSSPDYQIRWS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALRQLEECVGTIPPAPLLHTVHVLSAYASIEPLTGVFKDPRVLDLLMHMLSSPDYQIRWS
              130       140       150       160       170       180

              190                                       200        
pF1KSD AGRMIQALSSHDAG--------------------------------TRTQILLSLSQQEA
       ::::::::::::::                                ::::::::::::::
XP_016 AGRMIQALSSHDAGEGQCGEEGKAGEGLGRLRDSQDTVAGASDLIRTRTQILLSLSQQEA
              190       200       210       220       230       240

      210       220       230       240       250       260        
pF1KSD IEKHLDFDSRCALLALFAQATLSEHPMSFEGIQLPQVPGRVLFSLVKRYLHVTSLLDQLN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IEKHLDFDSRCALLALFAQATLSEHPMSFEGIQLPQVPGRVLFSLVKRYLHVTSLLDQLN
              250       260       270       280       290       300

      270       280       290       300       310       320        
pF1KSD DSAAEPGAQNTSAPEELSGERGQLELEFSMAMGTLISELVQAMRWDQASDRPRSSARSPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSAAEPGAQNTSAPEELSGERGQLELEFSMAMGTLISELVQAMRWDQASDRPRSSARSPG
              310       320       330       340       350       360

      330       340       350       360       370       380        
pF1KSD SIFQPQLADVSPGLPAAQAQPSFRRSRRFRPRSEFASGNTYALYVRDTLQPGMRVRMLDD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SIFQPQLADVSPGLPAAQAQPSFRRSRRFRPRSEFASGNTYALYVRDTLQPGMRVRMLDD
              370       380       390       400       410       420

      390       400       410       420       430       440        
pF1KSD YEEISAGDEGEFRQSNNGVPPVQVFWESTGRTYWVHWHMLEILGFEEDIEDMVEADEYQG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YEEISAGDEGEFRQSNNGVPPVQVFWESTGRTYWVHWHMLEILGFEEDIEDMVEADEYQG
              430       440       450       460       470       480

      450       460       470       480       490       500        
pF1KSD AVASRVLGRALPAWRWRPMTELYAVPYVLPEDEDTEECEHLTLAEWWELLFFIKKLDGPD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVASRVLGRALPAWRWRPMTELYAVPYVLPEDEDTEECEHLTLAEWWELLFFIKKLDGPD
              490       500       510       520       530       540

      510       520       530       540       550       560        
pF1KSD HQEVLQILQENLDGEILDDEILAELAVPIELAQDLLLTLPQRLNDSALRDLINCHVYKKY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HQEVLQILQENLDGEILDDEILAELAVPIELAQDLLLTLPQRLNDSALRDLINCHVYKKY
              550       560       570       580       590       600

      570       580       590       600       610       620        
pF1KSD GPEALAGNQAYPSLLEAQEDVLLLDAQAQAKDSEDAAKVEAKEPPSQSPNTPLQRLVEGY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPEALAGNQAYPSLLEAQEDVLLLDAQAQAKDSEDAAKVEAKEPPSQSPNTPLQRLVEGY
              610       620       630       640       650       660

      630       640       650       660       670       680        
pF1KSD GPAGKILLDLEQALSSEGTQENKVKPLLLQLQRQPQPFLALMQSLDTPETNRTLHLTVLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPAGKILLDLEQALSSEGTQENKVKPLLLQLQRQPQPFLALMQSLDTPETNRTLHLTVLR
              670       680       690       700       710       720

      690       700       710       720       730       740        
pF1KSD ILKQLVDFPEALLLPWHEAVDACMACLRSPNTDREVLQELIFFLHRLTSVSRDYAVVLNQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILKQLVDFPEALLLPWHEAVDACMACLRSPNTDREVLQELIFFLHRLTSVSRDYAVVLNQ
              730       740       750       760       770       780

      750       760       770       780       790       800        
pF1KSD LGARDAISKALEKHLGKLELAQELRDMVFKCEKHAHLYRKLITNILGGCIQMVLGQIEDH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGARDAISKALEKHLGKLELAQELRDMVFKCEKHAHLYRKLITNILGGCIQMVLGQIEDH
              790       800       810       820       830       840

      810       820       830       840       850       860        
pF1KSD RRTHRPINIPFFDVFLRYLCQGSSVEVKEDKCWEKVEVSSNPHRASKLTDHNPKTYWESN
       ::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRTHQPINIPFFDVFLRYLCQGSSVEVKEDKCWEKVEVSSNPHRASKLTDHNPKTYWESN
              850       860       870       880       890       900

      870       880       890       900       910       920        
pF1KSD GSAGSHYITLHMRRGILIRQLTLLVASEDSSYMPARVVVCGGDSTSSLHTELNSVNVMPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSAGSHYITLHMRRGILIRQLTLLVASEDSSYMPARVVVCGGDSTSSLHTELNSVNVMPS
              910       920       930       940       950       960

      930       940       950       960       970       980        
pF1KSD ASRVILLENLTRFWPIIQIRIKRCQQGGIDTRIRGLEILGPKPTFWPVFREQLCRHTRLF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASRVILLENLTRFWPIIQIRIKRCQQGGIDTRIRGLEILGPKPTFWPVFREQLCRHTRLF
              970       980       990      1000      1010      1020

      990      1000      1010      1020      1030      1040        
pF1KSD YMVRAQAWSQDMAEDRRSLLHLSSRLNGALRQEQNFADRFLPDDEAAQALGKTCWEALVS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YMVRAQAWSQDMAEDRRSLLHLSSRLNGALRQEQNFADRFLPDDEAAQALGKTCWEALVS
             1030      1040      1050      1060      1070      1080

     1050      1060      1070      1080      1090      1100        
pF1KSD PVVQNITSPDEDGISPLGWLLDQYLECQEAVFNPQSRGPAFFSRVRRLTHLLVHVEPCEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PVVQNITSPDEDGISPLGWLLDQYLECQEAVFNPQSRGPAFFSRVRRLTHLLVHVEPCEA
             1090      1100      1110      1120      1130      1140

     1110      1120      1130      1140      1150      1160        
pF1KSD PPPVVATPRPKGRNRSHDWSSLATRGLPSSIMRNLTRCWRAVVEKQVNNFLTSSWRDDDF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPPVVATPRPKGRNRSHDWSSLATRGLPSSIMRNLTRCWRAVVEKQVNNFLTSSWRDDDF
             1150      1160      1170      1180      1190      1200

     1170      1180      1190      1200      1210      1220        
pF1KSD VPRYCEHFNILQNSSSELFGPRAAFLLALQNGCAGALLKLPFLKAAHVSEQFARHIDQQI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VPRYCEHFNILQNSSSELFGPRAAFLLALQNGCAGALLKLPFLKAAHVSEQFARHIDQQI
             1210      1220      1230      1240      1250      1260

     1230      1240      1250      1260      1270      1280        
pF1KSD QGSRIGGAQEMERLAQLQQCLQAVLIFSGLEIATTFEHYYQHYMADRLLGVVSSWLEGAV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QGSRIGGAQEMERLAQLQQCLQAVLIFSGLEIATTFEHYYQHYMADRLLGVVSSWLEGAV
             1270      1280      1290      1300      1310      1320

     1290      1300      1310      1320      1330      1340        
pF1KSD LEQIGPCFPNRLPQQMLQSLSTSKELQRQFHVYQLQQLDQELLKLEDTEKKIQVGLGASG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEQIGPCFPNRLPQQMLQSLSTSKELQRQFHVYQLQQLDQELLKLEDTEKKIQVGLGASG
             1330      1340      1350      1360      1370      1380

     1350      1360      1370      1380      1390      1400        
pF1KSD KEHKSEKEEEAGAAAVVDVAEGEEEEEENEDLYYEGAMPEVSVLVLSRHSWPVASICHTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEHKSEKEEEAGAAAVVDVAEGEEEEEENEDLYYEGAMPEVSVLVLSRHSWPVASICHTL
             1390      1400      1410      1420      1430      1440

     1410      1420      1430      1440      1450      1460        
pF1KSD NPRTCLPSYLRGTLNRYSNFYNKSQSHPALERGSQRRLQWTWLGWAELQFGNQTLHVSTV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NPRTCLPSYLRGTLNRYSNFYNKSQSHPALERGSQRRLQWTWLGWAELQFGNQTLHVSTV
             1450      1460      1470      1480      1490      1500

     1470      1480      1490      1500      1510      1520        
pF1KSD QMWLLLYLNDLKAVSVESLLAFSGLSADMLNQAIGPLTSSRGPLDLHEQKDIPGGVLKIR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QMWLLLYLNDLKAVSVESLLAFSGLSADMLNQAIGPLTSSRGPLDLHEQKDIPGGVLKIR
             1510      1520      1530      1540      1550      1560

     1530      1540      1550      1560      1570      1580        
pF1KSD DGSKEPRSRWDIVRLIPPQTYLQAEGEDGQNLEKRRNLLNCLIVRILKAHGDEGLHIDQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DGSKEPRSRWDIVRLIPPQTYLQAEGEDGQNLEKRRNLLNCLIVRILKAHGDEGLHIDQL
             1570      1580      1590      1600      1610      1620

     1590      1600      1610      1620      1630      1640        
pF1KSD VCLVLEAWQKGPCPPRGLVSSLGKGSACSSTDVLSCILHLLGKGTLRRHDDRPQVLSYAV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VCLVLEAWQKGPCPPRGLVSSLGKGSACSSTDVLSCILHLLGKGTLRRHDDRPQVLSYAV
             1630      1640      1650      1660      1670      1680

     1650      1660      1670      1680      1690        
pF1KSD PVTVMEPHTESLNPGSSGPNPPLTFHTLQIRSRGVPYASCTATQSFSTFR
       ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PVTVMEPHTESLNPGSSGPNPPLTFHTLQIRSRGVPYASCTATQSFSTFR
             1690      1700      1710      1720      1730

>>NP_001161842 (OMIM: 273750,609577) cullin-7 isoform 1   (1782 aa)
 initn: 11411 init1: 10099 opt: 10099  Z-score: 10929.9  bits: 2035.5 E(85289):    0
Smith-Waterman score: 11351; 98.1% identity (98.2% similar) in 1730 aa overlap (1-1698:53-1782)

                                             10        20        30
pF1KSD                               MVGELRYREFRVPLGPGLHAYPDELIRQRV
                                     ::::::::::::::::::::::::::::::
NP_001 ADSRGCSSVPRRHAPSRLSVSTPSRGPGARMVGELRYREFRVPLGPGLHAYPDELIRQRV
             30        40        50        60        70        80  

               40        50        60        70        80        90
pF1KSD GHDGHPEYQIRWLILRRGDEGDGGSGQVDCKAEHILLWMSKDEIYANCHKMLGEDGQVIG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GHDGHPEYQIRWLILRRGDEGDGGSGQVDCKAEHILLWMSKDEIYANCHKMLGEDGQVIG
             90       100       110       120       130       140  

              100       110       120       130       140       150
pF1KSD PSQESAGEVGALDKSVLEEMETDVKSLIQRALRQLEECVGTIPPAPLLHTVHVLSAYASI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSQESAGEVGALDKSVLEEMETDVKSLIQRALRQLEECVGTIPPAPLLHTVHVLSAYASI
            150       160       170       180       190       200  

              160       170       180       190                    
pF1KSD EPLTGVFKDPRVLDLLMHMLSSPDYQIRWSAGRMIQALSSHDAG----------------
       ::::::::::::::::::::::::::::::::::::::::::::                
NP_001 EPLTGVFKDPRVLDLLMHMLSSPDYQIRWSAGRMIQALSSHDAGEGQCGEEGKAGEGLGR
            210       220       230       240       250       260  

                          200       210       220       230        
pF1KSD ----------------TRTQILLSLSQQEAIEKHLDFDSRCALLALFAQATLSEHPMSFE
                       ::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRDSQDTVAGASDLIRTRTQILLSLSQQEAIEKHLDFDSRCALLALFAQATLSEHPMSFE
            270       280       290       300       310       320  

      240       250       260       270       280       290        
pF1KSD GIQLPQVPGRVLFSLVKRYLHVTSLLDQLNDSAAEPGAQNTSAPEELSGERGQLELEFSM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GIQLPQVPGRVLFSLVKRYLHVTSLLDQLNDSAAEPGAQNTSAPEELSGERGQLELEFSM
            330       340       350       360       370       380  

      300       310       320       330       340       350        
pF1KSD AMGTLISELVQAMRWDQASDRPRSSARSPGSIFQPQLADVSPGLPAAQAQPSFRRSRRFR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AMGTLISELVQAMRWDQASDRPRSSARSPGSIFQPQLADVSPGLPAAQAQPSFRRSRRFR
            390       400       410       420       430       440  

      360       370       380       390       400       410        
pF1KSD PRSEFASGNTYALYVRDTLQPGMRVRMLDDYEEISAGDEGEFRQSNNGVPPVQVFWESTG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PRSEFASGNTYALYVRDTLQPGMRVRMLDDYEEISAGDEGEFRQSNNGVPPVQVFWESTG
            450       460       470       480       490       500  

      420       430       440       450       460       470        
pF1KSD RTYWVHWHMLEILGFEEDIEDMVEADEYQGAVASRVLGRALPAWRWRPMTELYAVPYVLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RTYWVHWHMLEILGFEEDIEDMVEADEYQGAVASRVLGRALPAWRWRPMTELYAVPYVLP
            510       520       530       540       550       560  

      480       490       500       510       520       530        
pF1KSD EDEDTEECEHLTLAEWWELLFFIKKLDGPDHQEVLQILQENLDGEILDDEILAELAVPIE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDEDTEECEHLTLAEWWELLFFIKKLDGPDHQEVLQILQENLDGEILDDEILAELAVPIE
            570       580       590       600       610       620  

      540       550       560       570       580       590        
pF1KSD LAQDLLLTLPQRLNDSALRDLINCHVYKKYGPEALAGNQAYPSLLEAQEDVLLLDAQAQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAQDLLLTLPQRLNDSALRDLINCHVYKKYGPEALAGNQAYPSLLEAQEDVLLLDAQAQA
            630       640       650       660       670       680  

      600       610       620       630       640       650        
pF1KSD KDSEDAAKVEAKEPPSQSPNTPLQRLVEGYGPAGKILLDLEQALSSEGTQENKVKPLLLQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDSEDAAKVEAKEPPSQSPNTPLQRLVEGYGPAGKILLDLEQALSSEGTQENKVKPLLLQ
            690       700       710       720       730       740  

      660       670       680       690       700       710        
pF1KSD LQRQPQPFLALMQSLDTPETNRTLHLTVLRILKQLVDFPEALLLPWHEAVDACMACLRSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQRQPQPFLALMQSLDTPETNRTLHLTVLRILKQLVDFPEALLLPWHEAVDACMACLRSP
            750       760       770       780       790       800  

      720       730       740       750       760       770        
pF1KSD NTDREVLQELIFFLHRLTSVSRDYAVVLNQLGARDAISKALEKHLGKLELAQELRDMVFK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NTDREVLQELIFFLHRLTSVSRDYAVVLNQLGARDAISKALEKHLGKLELAQELRDMVFK
            810       820       830       840       850       860  

      780       790       800       810       820       830        
pF1KSD CEKHAHLYRKLITNILGGCIQMVLGQIEDHRRTHRPINIPFFDVFLRYLCQGSSVEVKED
       ::::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::
NP_001 CEKHAHLYRKLITNILGGCIQMVLGQIEDHRRTHQPINIPFFDVFLRYLCQGSSVEVKED
            870       880       890       900       910       920  

      840       850       860       870       880       890        
pF1KSD KCWEKVEVSSNPHRASKLTDHNPKTYWESNGSAGSHYITLHMRRGILIRQLTLLVASEDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KCWEKVEVSSNPHRASKLTDHNPKTYWESNGSAGSHYITLHMRRGILIRQLTLLVASEDS
            930       940       950       960       970       980  

      900       910       920       930       940       950        
pF1KSD SYMPARVVVCGGDSTSSLHTELNSVNVMPSASRVILLENLTRFWPIIQIRIKRCQQGGID
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SYMPARVVVCGGDSTSSLHTELNSVNVMPSASRVILLENLTRFWPIIQIRIKRCQQGGID
            990      1000      1010      1020      1030      1040  

      960       970       980       990      1000      1010        
pF1KSD TRIRGLEILGPKPTFWPVFREQLCRHTRLFYMVRAQAWSQDMAEDRRSLLHLSSRLNGAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TRIRGLEILGPKPTFWPVFREQLCRHTRLFYMVRAQAWSQDMAEDRRSLLHLSSRLNGAL
           1050      1060      1070      1080      1090      1100  

     1020      1030      1040      1050      1060      1070        
pF1KSD RQEQNFADRFLPDDEAAQALGKTCWEALVSPVVQNITSPDEDGISPLGWLLDQYLECQEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RQEQNFADRFLPDDEAAQALGKTCWEALVSPVVQNITSPDEDGISPLGWLLDQYLECQEA
           1110      1120      1130      1140      1150      1160  

     1080      1090      1100      1110      1120      1130        
pF1KSD VFNPQSRGPAFFSRVRRLTHLLVHVEPCEAPPPVVATPRPKGRNRSHDWSSLATRGLPSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VFNPQSRGPAFFSRVRRLTHLLVHVEPCEAPPPVVATPRPKGRNRSHDWSSLATRGLPSS
           1170      1180      1190      1200      1210      1220  

     1140      1150      1160      1170      1180      1190        
pF1KSD IMRNLTRCWRAVVEKQVNNFLTSSWRDDDFVPRYCEHFNILQNSSSELFGPRAAFLLALQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IMRNLTRCWRAVVEKQVNNFLTSSWRDDDFVPRYCEHFNILQNSSSELFGPRAAFLLALQ
           1230      1240      1250      1260      1270      1280  

     1200      1210      1220      1230      1240      1250        
pF1KSD NGCAGALLKLPFLKAAHVSEQFARHIDQQIQGSRIGGAQEMERLAQLQQCLQAVLIFSGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NGCAGALLKLPFLKAAHVSEQFARHIDQQIQGSRIGGAQEMERLAQLQQCLQAVLIFSGL
           1290      1300      1310      1320      1330      1340  

     1260      1270      1280      1290      1300      1310        
pF1KSD EIATTFEHYYQHYMADRLLGVVSSWLEGAVLEQIGPCFPNRLPQQMLQSLSTSKELQRQF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EIATTFEHYYQHYMADRLLGVVSSWLEGAVLEQIGPCFPNRLPQQMLQSLSTSKELQRQF
           1350      1360      1370      1380      1390      1400  

     1320      1330      1340      1350      1360      1370        
pF1KSD HVYQLQQLDQELLKLEDTEKKIQVGLGASGKEHKSEKEEEAGAAAVVDVAEGEEEEEENE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HVYQLQQLDQELLKLEDTEKKIQVGLGASGKEHKSEKEEEAGAAAVVDVAEGEEEEEENE
           1410      1420      1430      1440      1450      1460  

     1380      1390      1400      1410      1420      1430        
pF1KSD DLYYEGAMPEVSVLVLSRHSWPVASICHTLNPRTCLPSYLRGTLNRYSNFYNKSQSHPAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLYYEGAMPEVSVLVLSRHSWPVASICHTLNPRTCLPSYLRGTLNRYSNFYNKSQSHPAL
           1470      1480      1490      1500      1510      1520  

     1440      1450      1460      1470      1480      1490        
pF1KSD ERGSQRRLQWTWLGWAELQFGNQTLHVSTVQMWLLLYLNDLKAVSVESLLAFSGLSADML
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERGSQRRLQWTWLGWAELQFGNQTLHVSTVQMWLLLYLNDLKAVSVESLLAFSGLSADML
           1530      1540      1550      1560      1570      1580  

     1500      1510      1520      1530      1540      1550        
pF1KSD NQAIGPLTSSRGPLDLHEQKDIPGGVLKIRDGSKEPRSRWDIVRLIPPQTYLQAEGEDGQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NQAIGPLTSSRGPLDLHEQKDIPGGVLKIRDGSKEPRSRWDIVRLIPPQTYLQAEGEDGQ
           1590      1600      1610      1620      1630      1640  

     1560      1570      1580      1590      1600      1610        
pF1KSD NLEKRRNLLNCLIVRILKAHGDEGLHIDQLVCLVLEAWQKGPCPPRGLVSSLGKGSACSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLEKRRNLLNCLIVRILKAHGDEGLHIDQLVCLVLEAWQKGPCPPRGLVSSLGKGSACSS
           1650      1660      1670      1680      1690      1700  

     1620      1630      1640      1650      1660      1670        
pF1KSD TDVLSCILHLLGKGTLRRHDDRPQVLSYAVPVTVMEPHTESLNPGSSGPNPPLTFHTLQI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TDVLSCILHLLGKGTLRRHDDRPQVLSYAVPVTVMEPHTESLNPGSSGPNPPLTFHTLQI
           1710      1720      1730      1740      1750      1760  

     1680      1690        
pF1KSD RSRGVPYASCTATQSFSTFR
       ::::::::::::::::::::
NP_001 RSRGVPYASCTATQSFSTFR
           1770      1780  

>>XP_006715348 (OMIM: 273750,609577) PREDICTED: cullin-7  (1734 aa)
 initn: 11398 init1: 8894 opt: 10081  Z-score: 10910.5  bits: 2031.9 E(85289):    0
Smith-Waterman score: 11333; 97.9% identity (97.9% similar) in 1734 aa overlap (1-1698:1-1734)

               10        20        30        40        50        60
pF1KSD MVGELRYREFRVPLGPGLHAYPDELIRQRVGHDGHPEYQIRWLILRRGDEGDGGSGQVDC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MVGELRYREFRVPLGPGLHAYPDELIRQRVGHDGHPEYQIRWLILRRGDEGDGGSGQVDC
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD KAEHILLWMSKDEIYANCHKMLGEDGQVIGPSQESAGEVGALDKSVLEEMETDVKSLIQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KAEHILLWMSKDEIYANCHKMLGEDGQVIGPSQESAGEVGALDKSVLEEMETDVKSLIQR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD ALRQLEECVGTIPPAPLLHTVHVLSAYASIEPLTGVFKDPRVLDLLMHMLSSPDYQIRWS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ALRQLEECVGTIPPAPLLHTVHVLSAYASIEPLTGVFKDPRVLDLLMHMLSSPDYQIRWS
              130       140       150       160       170       180

              190                                       200        
pF1KSD AGRMIQALSSHDAG--------------------------------TRTQILLSLSQQEA
       ::::::::::::::                                ::::::::::::::
XP_006 AGRMIQALSSHDAGEGQCGEEGKAGEGLGRLRDSQDTVAGASDLIRTRTQILLSLSQQEA
              190       200       210       220       230       240

      210       220       230       240       250       260        
pF1KSD IEKHLDFDSRCALLALFAQATLSEHPMSFEGIQLPQVPGRVLFSLVKRYLHVTSLLDQLN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IEKHLDFDSRCALLALFAQATLSEHPMSFEGIQLPQVPGRVLFSLVKRYLHVTSLLDQLN
              250       260       270       280       290       300

      270       280       290       300       310       320        
pF1KSD DSAAEPGAQNTSAPEELSGERGQLELEFSMAMGTLISELVQAMRWDQASDRPRSSARSPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DSAAEPGAQNTSAPEELSGERGQLELEFSMAMGTLISELVQAMRWDQASDRPRSSARSPG
              310       320       330       340       350       360

      330       340       350       360       370       380        
pF1KSD SIFQPQLADVSPGLPAAQAQPSFRRSRRFRPRSEFASGNTYALYVRDTLQPGMRVRMLDD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SIFQPQLADVSPGLPAAQAQPSFRRSRRFRPRSEFASGNTYALYVRDTLQPGMRVRMLDD
              370       380       390       400       410       420

      390       400       410       420       430       440        
pF1KSD YEEISAGDEGEFRQSNNGVPPVQVFWESTGRTYWVHWHMLEILGFEEDIEDMVEADEYQG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YEEISAGDEGEFRQSNNGVPPVQVFWESTGRTYWVHWHMLEILGFEEDIEDMVEADEYQG
              430       440       450       460       470       480

      450       460       470       480       490       500        
pF1KSD AVASRVLGRALPAWRWRPMTELYAVPYVLPEDEDTEECEHLTLAEWWELLFFIKKLDGPD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AVASRVLGRALPAWRWRPMTELYAVPYVLPEDEDTEECEHLTLAEWWELLFFIKKLDGPD
              490       500       510       520       530       540

      510       520       530       540       550       560        
pF1KSD HQEVLQILQENLDGEILDDEILAELAVPIELAQDLLLTLPQRLNDSALRDLINCHVYKKY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HQEVLQILQENLDGEILDDEILAELAVPIELAQDLLLTLPQRLNDSALRDLINCHVYKKY
              550       560       570       580       590       600

      570       580       590       600       610       620        
pF1KSD GPEALAGNQAYPSLLEAQEDVLLLDAQAQAKDSEDAAKVEAKEPPSQSPNTPLQRLVEGY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GPEALAGNQAYPSLLEAQEDVLLLDAQAQAKDSEDAAKVEAKEPPSQSPNTPLQRLVEGY
              610       620       630       640       650       660

      630       640       650       660       670       680        
pF1KSD GPAGKILLDLEQALSSEGTQENKVKPLLLQLQRQPQPFLALMQSLDTPETNRTLHLTVLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GPAGKILLDLEQALSSEGTQENKVKPLLLQLQRQPQPFLALMQSLDTPETNRTLHLTVLR
              670       680       690       700       710       720

      690       700       710       720       730       740        
pF1KSD ILKQLVDFPEALLLPWHEAVDACMACLRSPNTDREVLQELIFFLHRLTSVSRDYAVVLNQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ILKQLVDFPEALLLPWHEAVDACMACLRSPNTDREVLQELIFFLHRLTSVSRDYAVVLNQ
              730       740       750       760       770       780

      750       760       770       780       790       800        
pF1KSD LGARDAISKALEKHLGKLELAQELRDMVFKCEKHAHLYRKLITNILGGCIQMVLGQIEDH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LGARDAISKALEKHLGKLELAQELRDMVFKCEKHAHLYRKLITNILGGCIQMVLGQIEDH
              790       800       810       820       830       840

      810       820       830       840       850       860        
pF1KSD RRTHRPINIPFFDVFLRYLCQGSSVEVKEDKCWEKVEVSSNPHRASKLTDHNPKTYWESN
       ::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RRTHQPINIPFFDVFLRYLCQGSSVEVKEDKCWEKVEVSSNPHRASKLTDHNPKTYWESN
              850       860       870       880       890       900

      870       880       890       900       910       920        
pF1KSD GSAGSHYITLHMRRGILIRQLTLLVASEDSSYMPARVVVCGGDSTSSLHTELNSVNVMPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GSAGSHYITLHMRRGILIRQLTLLVASEDSSYMPARVVVCGGDSTSSLHTELNSVNVMPS
              910       920       930       940       950       960

      930       940       950       960       970       980        
pF1KSD ASRVILLENLTRFWPIIQIRIKRCQQGGIDTRIRGLEILGPKPTFWPVFREQLCRHTRLF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ASRVILLENLTRFWPIIQIRIKRCQQGGIDTRIRGLEILGPKPTFWPVFREQLCRHTRLF
              970       980       990      1000      1010      1020

      990      1000      1010      1020      1030      1040        
pF1KSD YMVRAQAWSQDMAEDRRSLLHLSSRLNGALRQEQNFADRFLPDDEAAQALGKTCWEALVS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YMVRAQAWSQDMAEDRRSLLHLSSRLNGALRQEQNFADRFLPDDEAAQALGKTCWEALVS
             1030      1040      1050      1060      1070      1080

     1050      1060      1070      1080      1090      1100        
pF1KSD PVVQNITSPDEDGISPLGWLLDQYLECQEAVFNPQSRGPAFFSRVRRLTHLLVHVEPCEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PVVQNITSPDEDGISPLGWLLDQYLECQEAVFNPQSRGPAFFSRVRRLTHLLVHVEPCEA
             1090      1100      1110      1120      1130      1140

     1110      1120      1130      1140      1150      1160        
pF1KSD PPPVVATPRPKGRNRSHDWSSLATRGLPSSIMRNLTRCWRAVVEKQVNNFLTSSWRDDDF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PPPVVATPRPKGRNRSHDWSSLATRGLPSSIMRNLTRCWRAVVEKQVNNFLTSSWRDDDF
             1150      1160      1170      1180      1190      1200

     1170      1180      1190      1200      1210      1220        
pF1KSD VPRYCEHFNILQNSSSELFGPRAAFLLALQNGCAGALLKLPFLKAAHVSEQFARHIDQQI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VPRYCEHFNILQNSSSELFGPRAAFLLALQNGCAGALLKLPFLKAAHVSEQFARHIDQQI
             1210      1220      1230      1240      1250      1260

     1230      1240      1250      1260      1270      1280        
pF1KSD QGSRIGGAQEMERLAQLQQCLQAVLIFSGLEIATTFEHYYQHYMADRLLGVVSSWLEGAV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QGSRIGGAQEMERLAQLQQCLQAVLIFSGLEIATTFEHYYQHYMADRLLGVVSSWLEGAV
             1270      1280      1290      1300      1310      1320

     1290      1300      1310      1320      1330      1340        
pF1KSD LEQIGPCFPNRLPQQMLQSLSTSKELQRQFHVYQLQQLDQELLKLEDTEKKIQVGLGASG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LEQIGPCFPNRLPQQMLQSLSTSKELQRQFHVYQLQQLDQELLKLEDTEKKIQVGLGASG
             1330      1340      1350      1360      1370      1380

     1350      1360      1370      1380      1390      1400        
pF1KSD KEHKSEKEEEAGAAAVVDVAEGEEEEEENEDLYYEGAMPEVSVLVLSRHSWPVASICHTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KEHKSEKEEEAGAAAVVDVAEGEEEEEENEDLYYEGAMPEVSVLVLSRHSWPVASICHTL
             1390      1400      1410      1420      1430      1440

     1410      1420      1430      1440      1450      1460        
pF1KSD NPRTCLPSYLRGTLNRYSNFYNKSQSHPALERGSQRRLQWTWLGWAELQFGNQTLHVSTV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NPRTCLPSYLRGTLNRYSNFYNKSQSHPALERGSQRRLQWTWLGWAELQFGNQTLHVSTV
             1450      1460      1470      1480      1490      1500

     1470      1480      1490      1500      1510      1520        
pF1KSD QMWLLLYLNDLKAVSVESLLAFSGLSADMLNQAIGPLTSSRGPLDLHEQKDIPG----GV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::    ::
XP_006 QMWLLLYLNDLKAVSVESLLAFSGLSADMLNQAIGPLTSSRGPLDLHEQKDIPGAFISGV
             1510      1520      1530      1540      1550      1560

         1530      1540      1550      1560      1570      1580    
pF1KSD LKIRDGSKEPRSRWDIVRLIPPQTYLQAEGEDGQNLEKRRNLLNCLIVRILKAHGDEGLH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LKIRDGSKEPRSRWDIVRLIPPQTYLQAEGEDGQNLEKRRNLLNCLIVRILKAHGDEGLH
             1570      1580      1590      1600      1610      1620

         1590      1600      1610      1620      1630      1640    
pF1KSD IDQLVCLVLEAWQKGPCPPRGLVSSLGKGSACSSTDVLSCILHLLGKGTLRRHDDRPQVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IDQLVCLVLEAWQKGPCPPRGLVSSLGKGSACSSTDVLSCILHLLGKGTLRRHDDRPQVL
             1630      1640      1650      1660      1670      1680

         1650      1660      1670      1680      1690        
pF1KSD SYAVPVTVMEPHTESLNPGSSGPNPPLTFHTLQIRSRGVPYASCTATQSFSTFR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SYAVPVTVMEPHTESLNPGSSGPNPPLTFHTLQIRSRGVPYASCTATQSFSTFR
             1690      1700      1710      1720      1730    

>>XP_011513321 (OMIM: 273750,609577) PREDICTED: cullin-7  (1786 aa)
 initn: 11398 init1: 8894 opt: 10081  Z-score: 10910.3  bits: 2031.9 E(85289):    0
Smith-Waterman score: 11333; 97.9% identity (97.9% similar) in 1734 aa overlap (1-1698:53-1786)

                                             10        20        30
pF1KSD                               MVGELRYREFRVPLGPGLHAYPDELIRQRV
                                     ::::::::::::::::::::::::::::::
XP_011 ADSRGCSSVPRRHAPSRLSVSTPSRGPGARMVGELRYREFRVPLGPGLHAYPDELIRQRV
             30        40        50        60        70        80  

               40        50        60        70        80        90
pF1KSD GHDGHPEYQIRWLILRRGDEGDGGSGQVDCKAEHILLWMSKDEIYANCHKMLGEDGQVIG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GHDGHPEYQIRWLILRRGDEGDGGSGQVDCKAEHILLWMSKDEIYANCHKMLGEDGQVIG
             90       100       110       120       130       140  

              100       110       120       130       140       150
pF1KSD PSQESAGEVGALDKSVLEEMETDVKSLIQRALRQLEECVGTIPPAPLLHTVHVLSAYASI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSQESAGEVGALDKSVLEEMETDVKSLIQRALRQLEECVGTIPPAPLLHTVHVLSAYASI
            150       160       170       180       190       200  

              160       170       180       190                    
pF1KSD EPLTGVFKDPRVLDLLMHMLSSPDYQIRWSAGRMIQALSSHDAG----------------
       ::::::::::::::::::::::::::::::::::::::::::::                
XP_011 EPLTGVFKDPRVLDLLMHMLSSPDYQIRWSAGRMIQALSSHDAGEGQCGEEGKAGEGLGR
            210       220       230       240       250       260  

                          200       210       220       230        
pF1KSD ----------------TRTQILLSLSQQEAIEKHLDFDSRCALLALFAQATLSEHPMSFE
                       ::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRDSQDTVAGASDLIRTRTQILLSLSQQEAIEKHLDFDSRCALLALFAQATLSEHPMSFE
            270       280       290       300       310       320  

      240       250       260       270       280       290        
pF1KSD GIQLPQVPGRVLFSLVKRYLHVTSLLDQLNDSAAEPGAQNTSAPEELSGERGQLELEFSM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GIQLPQVPGRVLFSLVKRYLHVTSLLDQLNDSAAEPGAQNTSAPEELSGERGQLELEFSM
            330       340       350       360       370       380  

      300       310       320       330       340       350        
pF1KSD AMGTLISELVQAMRWDQASDRPRSSARSPGSIFQPQLADVSPGLPAAQAQPSFRRSRRFR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AMGTLISELVQAMRWDQASDRPRSSARSPGSIFQPQLADVSPGLPAAQAQPSFRRSRRFR
            390       400       410       420       430       440  

      360       370       380       390       400       410        
pF1KSD PRSEFASGNTYALYVRDTLQPGMRVRMLDDYEEISAGDEGEFRQSNNGVPPVQVFWESTG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PRSEFASGNTYALYVRDTLQPGMRVRMLDDYEEISAGDEGEFRQSNNGVPPVQVFWESTG
            450       460       470       480       490       500  

      420       430       440       450       460       470        
pF1KSD RTYWVHWHMLEILGFEEDIEDMVEADEYQGAVASRVLGRALPAWRWRPMTELYAVPYVLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTYWVHWHMLEILGFEEDIEDMVEADEYQGAVASRVLGRALPAWRWRPMTELYAVPYVLP
            510       520       530       540       550       560  

      480       490       500       510       520       530        
pF1KSD EDEDTEECEHLTLAEWWELLFFIKKLDGPDHQEVLQILQENLDGEILDDEILAELAVPIE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDEDTEECEHLTLAEWWELLFFIKKLDGPDHQEVLQILQENLDGEILDDEILAELAVPIE
            570       580       590       600       610       620  

      540       550       560       570       580       590        
pF1KSD LAQDLLLTLPQRLNDSALRDLINCHVYKKYGPEALAGNQAYPSLLEAQEDVLLLDAQAQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAQDLLLTLPQRLNDSALRDLINCHVYKKYGPEALAGNQAYPSLLEAQEDVLLLDAQAQA
            630       640       650       660       670       680  

      600       610       620       630       640       650        
pF1KSD KDSEDAAKVEAKEPPSQSPNTPLQRLVEGYGPAGKILLDLEQALSSEGTQENKVKPLLLQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDSEDAAKVEAKEPPSQSPNTPLQRLVEGYGPAGKILLDLEQALSSEGTQENKVKPLLLQ
            690       700       710       720       730       740  

      660       670       680       690       700       710        
pF1KSD LQRQPQPFLALMQSLDTPETNRTLHLTVLRILKQLVDFPEALLLPWHEAVDACMACLRSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQRQPQPFLALMQSLDTPETNRTLHLTVLRILKQLVDFPEALLLPWHEAVDACMACLRSP
            750       760       770       780       790       800  

      720       730       740       750       760       770        
pF1KSD NTDREVLQELIFFLHRLTSVSRDYAVVLNQLGARDAISKALEKHLGKLELAQELRDMVFK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NTDREVLQELIFFLHRLTSVSRDYAVVLNQLGARDAISKALEKHLGKLELAQELRDMVFK
            810       820       830       840       850       860  

      780       790       800       810       820       830        
pF1KSD CEKHAHLYRKLITNILGGCIQMVLGQIEDHRRTHRPINIPFFDVFLRYLCQGSSVEVKED
       ::::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::
XP_011 CEKHAHLYRKLITNILGGCIQMVLGQIEDHRRTHQPINIPFFDVFLRYLCQGSSVEVKED
            870       880       890       900       910       920  

      840       850       860       870       880       890        
pF1KSD KCWEKVEVSSNPHRASKLTDHNPKTYWESNGSAGSHYITLHMRRGILIRQLTLLVASEDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KCWEKVEVSSNPHRASKLTDHNPKTYWESNGSAGSHYITLHMRRGILIRQLTLLVASEDS
            930       940       950       960       970       980  

      900       910       920       930       940       950        
pF1KSD SYMPARVVVCGGDSTSSLHTELNSVNVMPSASRVILLENLTRFWPIIQIRIKRCQQGGID
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SYMPARVVVCGGDSTSSLHTELNSVNVMPSASRVILLENLTRFWPIIQIRIKRCQQGGID
            990      1000      1010      1020      1030      1040  

      960       970       980       990      1000      1010        
pF1KSD TRIRGLEILGPKPTFWPVFREQLCRHTRLFYMVRAQAWSQDMAEDRRSLLHLSSRLNGAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TRIRGLEILGPKPTFWPVFREQLCRHTRLFYMVRAQAWSQDMAEDRRSLLHLSSRLNGAL
           1050      1060      1070      1080      1090      1100  

     1020      1030      1040      1050      1060      1070        
pF1KSD RQEQNFADRFLPDDEAAQALGKTCWEALVSPVVQNITSPDEDGISPLGWLLDQYLECQEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RQEQNFADRFLPDDEAAQALGKTCWEALVSPVVQNITSPDEDGISPLGWLLDQYLECQEA
           1110      1120      1130      1140      1150      1160  

     1080      1090      1100      1110      1120      1130        
pF1KSD VFNPQSRGPAFFSRVRRLTHLLVHVEPCEAPPPVVATPRPKGRNRSHDWSSLATRGLPSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VFNPQSRGPAFFSRVRRLTHLLVHVEPCEAPPPVVATPRPKGRNRSHDWSSLATRGLPSS
           1170      1180      1190      1200      1210      1220  

     1140      1150      1160      1170      1180      1190        
pF1KSD IMRNLTRCWRAVVEKQVNNFLTSSWRDDDFVPRYCEHFNILQNSSSELFGPRAAFLLALQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IMRNLTRCWRAVVEKQVNNFLTSSWRDDDFVPRYCEHFNILQNSSSELFGPRAAFLLALQ
           1230      1240      1250      1260      1270      1280  

     1200      1210      1220      1230      1240      1250        
pF1KSD NGCAGALLKLPFLKAAHVSEQFARHIDQQIQGSRIGGAQEMERLAQLQQCLQAVLIFSGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NGCAGALLKLPFLKAAHVSEQFARHIDQQIQGSRIGGAQEMERLAQLQQCLQAVLIFSGL
           1290      1300      1310      1320      1330      1340  

     1260      1270      1280      1290      1300      1310        
pF1KSD EIATTFEHYYQHYMADRLLGVVSSWLEGAVLEQIGPCFPNRLPQQMLQSLSTSKELQRQF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EIATTFEHYYQHYMADRLLGVVSSWLEGAVLEQIGPCFPNRLPQQMLQSLSTSKELQRQF
           1350      1360      1370      1380      1390      1400  

     1320      1330      1340      1350      1360      1370        
pF1KSD HVYQLQQLDQELLKLEDTEKKIQVGLGASGKEHKSEKEEEAGAAAVVDVAEGEEEEEENE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HVYQLQQLDQELLKLEDTEKKIQVGLGASGKEHKSEKEEEAGAAAVVDVAEGEEEEEENE
           1410      1420      1430      1440      1450      1460  

     1380      1390      1400      1410      1420      1430        
pF1KSD DLYYEGAMPEVSVLVLSRHSWPVASICHTLNPRTCLPSYLRGTLNRYSNFYNKSQSHPAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLYYEGAMPEVSVLVLSRHSWPVASICHTLNPRTCLPSYLRGTLNRYSNFYNKSQSHPAL
           1470      1480      1490      1500      1510      1520  

     1440      1450      1460      1470      1480      1490        
pF1KSD ERGSQRRLQWTWLGWAELQFGNQTLHVSTVQMWLLLYLNDLKAVSVESLLAFSGLSADML
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ERGSQRRLQWTWLGWAELQFGNQTLHVSTVQMWLLLYLNDLKAVSVESLLAFSGLSADML
           1530      1540      1550      1560      1570      1580  

     1500      1510      1520          1530      1540      1550    
pF1KSD NQAIGPLTSSRGPLDLHEQKDIPG----GVLKIRDGSKEPRSRWDIVRLIPPQTYLQAEG
       ::::::::::::::::::::::::    ::::::::::::::::::::::::::::::::
XP_011 NQAIGPLTSSRGPLDLHEQKDIPGAFISGVLKIRDGSKEPRSRWDIVRLIPPQTYLQAEG
           1590      1600      1610      1620      1630      1640  

         1560      1570      1580      1590      1600      1610    
pF1KSD EDGQNLEKRRNLLNCLIVRILKAHGDEGLHIDQLVCLVLEAWQKGPCPPRGLVSSLGKGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDGQNLEKRRNLLNCLIVRILKAHGDEGLHIDQLVCLVLEAWQKGPCPPRGLVSSLGKGS
           1650      1660      1670      1680      1690      1700  

         1620      1630      1640      1650      1660      1670    
pF1KSD ACSSTDVLSCILHLLGKGTLRRHDDRPQVLSYAVPVTVMEPHTESLNPGSSGPNPPLTFH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ACSSTDVLSCILHLLGKGTLRRHDDRPQVLSYAVPVTVMEPHTESLNPGSSGPNPPLTFH
           1710      1720      1730      1740      1750      1760  

         1680      1690        
pF1KSD TLQIRSRGVPYASCTATQSFSTFR
       ::::::::::::::::::::::::
XP_011 TLQIRSRGVPYASCTATQSFSTFR
           1770      1780      

>>XP_016867023 (OMIM: 273750,609577) PREDICTED: cullin-7  (1791 aa)
 initn: 9201 init1: 7889 opt: 7889  Z-score: 8535.5  bits: 1592.5 E(85289):    0
Smith-Waterman score: 11264; 97.6% identity (97.6% similar) in 1730 aa overlap (10-1698:62-1791)

                                    10        20        30         
pF1KSD                      MVGELRYREFRVPLGPGLHAYPDELIRQRVGHDGHPEYQ
                                     ::::::::::::::::::::::::::::::
XP_016 PRRHAPSRLSVSTPSRGPGARMVGELRYREFRVPLGPGLHAYPDELIRQRVGHDGHPEYQ
              40        50        60        70        80        90 

      40        50        60        70        80        90         
pF1KSD IRWLILRRGDEGDGGSGQVDCKAEHILLWMSKDEIYANCHKMLGEDGQVIGPSQESAGEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IRWLILRRGDEGDGGSGQVDCKAEHILLWMSKDEIYANCHKMLGEDGQVIGPSQESAGEV
             100       110       120       130       140       150 

     100       110       120       130       140       150         
pF1KSD GALDKSVLEEMETDVKSLIQRALRQLEECVGTIPPAPLLHTVHVLSAYASIEPLTGVFKD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GALDKSVLEEMETDVKSLIQRALRQLEECVGTIPPAPLLHTVHVLSAYASIEPLTGVFKD
             160       170       180       190       200       210 

     160       170       180       190                             
pF1KSD PRVLDLLMHMLSSPDYQIRWSAGRMIQALSSHDAG-------------------------
       :::::::::::::::::::::::::::::::::::                         
XP_016 PRVLDLLMHMLSSPDYQIRWSAGRMIQALSSHDAGEGQCGEEGKAGEGLGRLRDSQDTVA
             220       230       240       250       260       270 

                 200       210       220       230       240       
pF1KSD -------TRTQILLSLSQQEAIEKHLDFDSRCALLALFAQATLSEHPMSFEGIQLPQVPG
              :::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GASDLIRTRTQILLSLSQQEAIEKHLDFDSRCALLALFAQATLSEHPMSFEGIQLPQVPG
             280       290       300       310       320       330 

       250       260       270       280       290       300       
pF1KSD RVLFSLVKRYLHVTSLLDQLNDSAAEPGAQNTSAPEELSGERGQLELEFSMAMGTLISEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RVLFSLVKRYLHVTSLLDQLNDSAAEPGAQNTSAPEELSGERGQLELEFSMAMGTLISEL
             340       350       360       370       380       390 

       310       320       330       340       350       360       
pF1KSD VQAMRWDQASDRPRSSARSPGSIFQPQLADVSPGLPAAQAQPSFRRSRRFRPRSEFASGN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VQAMRWDQASDRPRSSARSPGSIFQPQLADVSPGLPAAQAQPSFRRSRRFRPRSEFASGN
             400       410       420       430       440       450 

       370       380       390       400       410       420       
pF1KSD TYALYVRDTLQPGMRVRMLDDYEEISAGDEGEFRQSNNGVPPVQVFWESTGRTYWVHWHM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TYALYVRDTLQPGMRVRMLDDYEEISAGDEGEFRQSNNGVPPVQVFWESTGRTYWVHWHM
             460       470       480       490       500       510 

       430       440       450       460       470       480       
pF1KSD LEILGFEEDIEDMVEADEYQGAVASRVLGRALPAWRWRPMTELYAVPYVLPEDEDTEECE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEILGFEEDIEDMVEADEYQGAVASRVLGRALPAWRWRPMTELYAVPYVLPEDEDTEECE
             520       530       540       550       560       570 

       490       500       510       520                530        
pF1KSD HLTLAEWWELLFFIKKLDGPDHQEVLQILQENLDGE---------ILDDEILAELAVPIE
       ::::::::::::::::::::::::::::::::::::         :::::::::::::::
XP_016 HLTLAEWWELLFFIKKLDGPDHQEVLQILQENLDGEVEPAWRHSEILDDEILAELAVPIE
             580       590       600       610       620       630 

      540       550       560       570       580       590        
pF1KSD LAQDLLLTLPQRLNDSALRDLINCHVYKKYGPEALAGNQAYPSLLEAQEDVLLLDAQAQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAQDLLLTLPQRLNDSALRDLINCHVYKKYGPEALAGNQAYPSLLEAQEDVLLLDAQAQA
             640       650       660       670       680       690 

      600       610       620       630       640       650        
pF1KSD KDSEDAAKVEAKEPPSQSPNTPLQRLVEGYGPAGKILLDLEQALSSEGTQENKVKPLLLQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KDSEDAAKVEAKEPPSQSPNTPLQRLVEGYGPAGKILLDLEQALSSEGTQENKVKPLLLQ
             700       710       720       730       740       750 

      660       670       680       690       700       710        
pF1KSD LQRQPQPFLALMQSLDTPETNRTLHLTVLRILKQLVDFPEALLLPWHEAVDACMACLRSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQRQPQPFLALMQSLDTPETNRTLHLTVLRILKQLVDFPEALLLPWHEAVDACMACLRSP
             760       770       780       790       800       810 

      720       730       740       750       760       770        
pF1KSD NTDREVLQELIFFLHRLTSVSRDYAVVLNQLGARDAISKALEKHLGKLELAQELRDMVFK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NTDREVLQELIFFLHRLTSVSRDYAVVLNQLGARDAISKALEKHLGKLELAQELRDMVFK
             820       830       840       850       860       870 

      780       790       800       810       820       830        
pF1KSD CEKHAHLYRKLITNILGGCIQMVLGQIEDHRRTHRPINIPFFDVFLRYLCQGSSVEVKED
       ::::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::
XP_016 CEKHAHLYRKLITNILGGCIQMVLGQIEDHRRTHQPINIPFFDVFLRYLCQGSSVEVKED
             880       890       900       910       920       930 

      840       850       860       870       880       890        
pF1KSD KCWEKVEVSSNPHRASKLTDHNPKTYWESNGSAGSHYITLHMRRGILIRQLTLLVASEDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KCWEKVEVSSNPHRASKLTDHNPKTYWESNGSAGSHYITLHMRRGILIRQLTLLVASEDS
             940       950       960       970       980       990 

      900       910       920       930       940       950        
pF1KSD SYMPARVVVCGGDSTSSLHTELNSVNVMPSASRVILLENLTRFWPIIQIRIKRCQQGGID
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SYMPARVVVCGGDSTSSLHTELNSVNVMPSASRVILLENLTRFWPIIQIRIKRCQQGGID
            1000      1010      1020      1030      1040      1050 

      960       970       980       990      1000      1010        
pF1KSD TRIRGLEILGPKPTFWPVFREQLCRHTRLFYMVRAQAWSQDMAEDRRSLLHLSSRLNGAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TRIRGLEILGPKPTFWPVFREQLCRHTRLFYMVRAQAWSQDMAEDRRSLLHLSSRLNGAL
            1060      1070      1080      1090      1100      1110 

     1020      1030      1040      1050      1060      1070        
pF1KSD RQEQNFADRFLPDDEAAQALGKTCWEALVSPVVQNITSPDEDGISPLGWLLDQYLECQEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQEQNFADRFLPDDEAAQALGKTCWEALVSPVVQNITSPDEDGISPLGWLLDQYLECQEA
            1120      1130      1140      1150      1160      1170 

     1080      1090      1100      1110      1120      1130        
pF1KSD VFNPQSRGPAFFSRVRRLTHLLVHVEPCEAPPPVVATPRPKGRNRSHDWSSLATRGLPSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VFNPQSRGPAFFSRVRRLTHLLVHVEPCEAPPPVVATPRPKGRNRSHDWSSLATRGLPSS
            1180      1190      1200      1210      1220      1230 

     1140      1150      1160      1170      1180      1190        
pF1KSD IMRNLTRCWRAVVEKQVNNFLTSSWRDDDFVPRYCEHFNILQNSSSELFGPRAAFLLALQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IMRNLTRCWRAVVEKQVNNFLTSSWRDDDFVPRYCEHFNILQNSSSELFGPRAAFLLALQ
            1240      1250      1260      1270      1280      1290 

     1200      1210      1220      1230      1240      1250        
pF1KSD NGCAGALLKLPFLKAAHVSEQFARHIDQQIQGSRIGGAQEMERLAQLQQCLQAVLIFSGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NGCAGALLKLPFLKAAHVSEQFARHIDQQIQGSRIGGAQEMERLAQLQQCLQAVLIFSGL
            1300      1310      1320      1330      1340      1350 

     1260      1270      1280      1290      1300      1310        
pF1KSD EIATTFEHYYQHYMADRLLGVVSSWLEGAVLEQIGPCFPNRLPQQMLQSLSTSKELQRQF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EIATTFEHYYQHYMADRLLGVVSSWLEGAVLEQIGPCFPNRLPQQMLQSLSTSKELQRQF
            1360      1370      1380      1390      1400      1410 

     1320      1330      1340      1350      1360      1370        
pF1KSD HVYQLQQLDQELLKLEDTEKKIQVGLGASGKEHKSEKEEEAGAAAVVDVAEGEEEEEENE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HVYQLQQLDQELLKLEDTEKKIQVGLGASGKEHKSEKEEEAGAAAVVDVAEGEEEEEENE
            1420      1430      1440      1450      1460      1470 

     1380      1390      1400      1410      1420      1430        
pF1KSD DLYYEGAMPEVSVLVLSRHSWPVASICHTLNPRTCLPSYLRGTLNRYSNFYNKSQSHPAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLYYEGAMPEVSVLVLSRHSWPVASICHTLNPRTCLPSYLRGTLNRYSNFYNKSQSHPAL
            1480      1490      1500      1510      1520      1530 

     1440      1450      1460      1470      1480      1490        
pF1KSD ERGSQRRLQWTWLGWAELQFGNQTLHVSTVQMWLLLYLNDLKAVSVESLLAFSGLSADML
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ERGSQRRLQWTWLGWAELQFGNQTLHVSTVQMWLLLYLNDLKAVSVESLLAFSGLSADML
            1540      1550      1560      1570      1580      1590 

     1500      1510      1520      1530      1540      1550        
pF1KSD NQAIGPLTSSRGPLDLHEQKDIPGGVLKIRDGSKEPRSRWDIVRLIPPQTYLQAEGEDGQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NQAIGPLTSSRGPLDLHEQKDIPGGVLKIRDGSKEPRSRWDIVRLIPPQTYLQAEGEDGQ
            1600      1610      1620      1630      1640      1650 

     1560      1570      1580      1590      1600      1610        
pF1KSD NLEKRRNLLNCLIVRILKAHGDEGLHIDQLVCLVLEAWQKGPCPPRGLVSSLGKGSACSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NLEKRRNLLNCLIVRILKAHGDEGLHIDQLVCLVLEAWQKGPCPPRGLVSSLGKGSACSS
            1660      1670      1680      1690      1700      1710 

     1620      1630      1640      1650      1660      1670        
pF1KSD TDVLSCILHLLGKGTLRRHDDRPQVLSYAVPVTVMEPHTESLNPGSSGPNPPLTFHTLQI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDVLSCILHLLGKGTLRRHDDRPQVLSYAVPVTVMEPHTESLNPGSSGPNPPLTFHTLQI
            1720      1730      1740      1750      1760      1770 

     1680      1690        
pF1KSD RSRGVPYASCTATQSFSTFR
       ::::::::::::::::::::
XP_016 RSRGVPYASCTATQSFSTFR
            1780      1790 

>>XP_016867027 (OMIM: 273750,609577) PREDICTED: cullin-7  (1711 aa)
 initn: 11408 init1: 6684 opt: 7871  Z-score: 8516.2  bits: 1588.8 E(85289):    0
Smith-Waterman score: 11379; 99.2% identity (99.2% similar) in 1711 aa overlap (1-1698:1-1711)

               10        20        30        40        50        60
pF1KSD MVGELRYREFRVPLGPGLHAYPDELIRQRVGHDGHPEYQIRWLILRRGDEGDGGSGQVDC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MVGELRYREFRVPLGPGLHAYPDELIRQRVGHDGHPEYQIRWLILRRGDEGDGGSGQVDC
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD KAEHILLWMSKDEIYANCHKMLGEDGQVIGPSQESAGEVGALDKSVLEEMETDVKSLIQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KAEHILLWMSKDEIYANCHKMLGEDGQVIGPSQESAGEVGALDKSVLEEMETDVKSLIQR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD ALRQLEECVGTIPPAPLLHTVHVLSAYASIEPLTGVFKDPRVLDLLMHMLSSPDYQIRWS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALRQLEECVGTIPPAPLLHTVHVLSAYASIEPLTGVFKDPRVLDLLMHMLSSPDYQIRWS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD AGRMIQALSSHDAGTRTQILLSLSQQEAIEKHLDFDSRCALLALFAQATLSEHPMSFEGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGRMIQALSSHDAGTRTQILLSLSQQEAIEKHLDFDSRCALLALFAQATLSEHPMSFEGI
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD QLPQVPGRVLFSLVKRYLHVTSLLDQLNDSAAEPGAQNTSAPEELSGERGQLELEFSMAM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLPQVPGRVLFSLVKRYLHVTSLLDQLNDSAAEPGAQNTSAPEELSGERGQLELEFSMAM
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD GTLISELVQAMRWDQASDRPRSSARSPGSIFQPQLADVSPGLPAAQAQPSFRRSRRFRPR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTLISELVQAMRWDQASDRPRSSARSPGSIFQPQLADVSPGLPAAQAQPSFRRSRRFRPR
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD SEFASGNTYALYVRDTLQPGMRVRMLDDYEEISAGDEGEFRQSNNGVPPVQVFWESTGRT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SEFASGNTYALYVRDTLQPGMRVRMLDDYEEISAGDEGEFRQSNNGVPPVQVFWESTGRT
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD YWVHWHMLEILGFEEDIEDMVEADEYQGAVASRVLGRALPAWRWRPMTELYAVPYVLPED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YWVHWHMLEILGFEEDIEDMVEADEYQGAVASRVLGRALPAWRWRPMTELYAVPYVLPED
              430       440       450       460       470       480

              490       500       510       520                530 
pF1KSD EDTEECEHLTLAEWWELLFFIKKLDGPDHQEVLQILQENLDGE---------ILDDEILA
       :::::::::::::::::::::::::::::::::::::::::::         ::::::::
XP_016 EDTEECEHLTLAEWWELLFFIKKLDGPDHQEVLQILQENLDGEVEPAWRHSEILDDEILA
              490       500       510       520       530       540

             540       550       560       570       580       590 
pF1KSD ELAVPIELAQDLLLTLPQRLNDSALRDLINCHVYKKYGPEALAGNQAYPSLLEAQEDVLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELAVPIELAQDLLLTLPQRLNDSALRDLINCHVYKKYGPEALAGNQAYPSLLEAQEDVLL
              550       560       570       580       590       600

             600       610       620       630       640       650 
pF1KSD LDAQAQAKDSEDAAKVEAKEPPSQSPNTPLQRLVEGYGPAGKILLDLEQALSSEGTQENK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDAQAQAKDSEDAAKVEAKEPPSQSPNTPLQRLVEGYGPAGKILLDLEQALSSEGTQENK
              610       620       630       640       650       660

             660       670       680       690       700       710 
pF1KSD VKPLLLQLQRQPQPFLALMQSLDTPETNRTLHLTVLRILKQLVDFPEALLLPWHEAVDAC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKPLLLQLQRQPQPFLALMQSLDTPETNRTLHLTVLRILKQLVDFPEALLLPWHEAVDAC
              670       680       690       700       710       720

             720       730       740       750       760       770 
pF1KSD MACLRSPNTDREVLQELIFFLHRLTSVSRDYAVVLNQLGARDAISKALEKHLGKLELAQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MACLRSPNTDREVLQELIFFLHRLTSVSRDYAVVLNQLGARDAISKALEKHLGKLELAQE
              730       740       750       760       770       780

             780       790       800       810       820       830 
pF1KSD LRDMVFKCEKHAHLYRKLITNILGGCIQMVLGQIEDHRRTHRPINIPFFDVFLRYLCQGS
       :::::::::::::::::::::::::::::::::::::::::.::::::::::::::::::
XP_016 LRDMVFKCEKHAHLYRKLITNILGGCIQMVLGQIEDHRRTHQPINIPFFDVFLRYLCQGS
              790       800       810       820       830       840

             840       850       860       870       880       890 
pF1KSD SVEVKEDKCWEKVEVSSNPHRASKLTDHNPKTYWESNGSAGSHYITLHMRRGILIRQLTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVEVKEDKCWEKVEVSSNPHRASKLTDHNPKTYWESNGSAGSHYITLHMRRGILIRQLTL
              850       860       870       880       890       900

             900       910       920       930       940       950 
pF1KSD LVASEDSSYMPARVVVCGGDSTSSLHTELNSVNVMPSASRVILLENLTRFWPIIQIRIKR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVASEDSSYMPARVVVCGGDSTSSLHTELNSVNVMPSASRVILLENLTRFWPIIQIRIKR
              910       920       930       940       950       960

             960       970       980       990      1000      1010 
pF1KSD CQQGGIDTRIRGLEILGPKPTFWPVFREQLCRHTRLFYMVRAQAWSQDMAEDRRSLLHLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CQQGGIDTRIRGLEILGPKPTFWPVFREQLCRHTRLFYMVRAQAWSQDMAEDRRSLLHLS
              970       980       990      1000      1010      1020

            1020      1030      1040      1050      1060      1070 
pF1KSD SRLNGALRQEQNFADRFLPDDEAAQALGKTCWEALVSPVVQNITSPDEDGISPLGWLLDQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SRLNGALRQEQNFADRFLPDDEAAQALGKTCWEALVSPVVQNITSPDEDGISPLGWLLDQ
             1030      1040      1050      1060      1070      1080

            1080      1090      1100      1110      1120      1130 
pF1KSD YLECQEAVFNPQSRGPAFFSRVRRLTHLLVHVEPCEAPPPVVATPRPKGRNRSHDWSSLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YLECQEAVFNPQSRGPAFFSRVRRLTHLLVHVEPCEAPPPVVATPRPKGRNRSHDWSSLA
             1090      1100      1110      1120      1130      1140

            1140      1150      1160      1170      1180      1190 
pF1KSD TRGLPSSIMRNLTRCWRAVVEKQVNNFLTSSWRDDDFVPRYCEHFNILQNSSSELFGPRA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TRGLPSSIMRNLTRCWRAVVEKQVNNFLTSSWRDDDFVPRYCEHFNILQNSSSELFGPRA
             1150      1160      1170      1180      1190      1200

            1200      1210      1220      1230      1240      1250 
pF1KSD AFLLALQNGCAGALLKLPFLKAAHVSEQFARHIDQQIQGSRIGGAQEMERLAQLQQCLQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AFLLALQNGCAGALLKLPFLKAAHVSEQFARHIDQQIQGSRIGGAQEMERLAQLQQCLQA
             1210      1220      1230      1240      1250      1260

            1260      1270      1280      1290      1300      1310 
pF1KSD VLIFSGLEIATTFEHYYQHYMADRLLGVVSSWLEGAVLEQIGPCFPNRLPQQMLQSLSTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLIFSGLEIATTFEHYYQHYMADRLLGVVSSWLEGAVLEQIGPCFPNRLPQQMLQSLSTS
             1270      1280      1290      1300      1310      1320

            1320      1330      1340      1350      1360      1370 
pF1KSD KELQRQFHVYQLQQLDQELLKLEDTEKKIQVGLGASGKEHKSEKEEEAGAAAVVDVAEGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KELQRQFHVYQLQQLDQELLKLEDTEKKIQVGLGASGKEHKSEKEEEAGAAAVVDVAEGE
             1330      1340      1350      1360      1370      1380

            1380      1390      1400      1410      1420      1430 
pF1KSD EEEEENEDLYYEGAMPEVSVLVLSRHSWPVASICHTLNPRTCLPSYLRGTLNRYSNFYNK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEEEENEDLYYEGAMPEVSVLVLSRHSWPVASICHTLNPRTCLPSYLRGTLNRYSNFYNK
             1390      1400      1410      1420      1430      1440

            1440      1450      1460      1470      1480      1490 
pF1KSD SQSHPALERGSQRRLQWTWLGWAELQFGNQTLHVSTVQMWLLLYLNDLKAVSVESLLAFS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQSHPALERGSQRRLQWTWLGWAELQFGNQTLHVSTVQMWLLLYLNDLKAVSVESLLAFS
             1450      1460      1470      1480      1490      1500

            1500      1510      1520          1530      1540       
pF1KSD GLSADMLNQAIGPLTSSRGPLDLHEQKDIPG----GVLKIRDGSKEPRSRWDIVRLIPPQ
       :::::::::::::::::::::::::::::::    :::::::::::::::::::::::::
XP_016 GLSADMLNQAIGPLTSSRGPLDLHEQKDIPGAFISGVLKIRDGSKEPRSRWDIVRLIPPQ
             1510      1520      1530      1540      1550      1560

      1550      1560      1570      1580      1590      1600       
pF1KSD TYLQAEGEDGQNLEKRRNLLNCLIVRILKAHGDEGLHIDQLVCLVLEAWQKGPCPPRGLV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TYLQAEGEDGQNLEKRRNLLNCLIVRILKAHGDEGLHIDQLVCLVLEAWQKGPCPPRGLV
             1570      1580      1590      1600      1610      1620

      1610      1620      1630      1640      1650      1660       
pF1KSD SSLGKGSACSSTDVLSCILHLLGKGTLRRHDDRPQVLSYAVPVTVMEPHTESLNPGSSGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSLGKGSACSSTDVLSCILHLLGKGTLRRHDDRPQVLSYAVPVTVMEPHTESLNPGSSGP
             1630      1640      1650      1660      1670      1680

      1670      1680      1690        
pF1KSD NPPLTFHTLQIRSRGVPYASCTATQSFSTFR
       :::::::::::::::::::::::::::::::
XP_016 NPPLTFHTLQIRSRGVPYASCTATQSFSTFR
             1690      1700      1710 




1698 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Wed Nov  2 23:49:41 2016 done: Wed Nov  2 23:49:43 2016
 Total Scan time: 18.610 Total Display time:  1.020

Function used was FASTA [36.3.4 Apr, 2011]
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