Result of FASTA (omim) for pF1KA1625
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KA1625, 757 aa
  1>>>pF1KA1625 757 - 757 aa - 757 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 6.7561+/-0.000449; mu= 13.3330+/- 0.028
 mean_var=148.3703+/-30.618, 0's: 0 Z-trim(115.0): 353  B-trim: 381 in 1/55
 Lambda= 0.105293
 statistics sampled from 24722 (25147) to 24722 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.661), E-opt: 0.2 (0.295), width:  16
 Scan time: 10.980

The best scores are:                                      opt bits E(85289)
NP_065162 (OMIM: 605568) E3 ubiquitin-protein liga ( 757) 5212 804.6       0
XP_016867946 (OMIM: 605568) PREDICTED: E3 ubiquiti ( 754) 5178 799.5       0
NP_073576 (OMIM: 605532) E3 ubiquitin-protein liga ( 748) 3539 550.5 9.4e-156
XP_011523430 (OMIM: 605532) PREDICTED: E3 ubiquiti ( 750) 3465 539.2 2.3e-152
XP_005257642 (OMIM: 605532) PREDICTED: E3 ubiquiti ( 735) 3370 524.8 4.9e-148
NP_851994 (OMIM: 605568) E3 ubiquitin-protein liga ( 731) 3194 498.1 5.5e-140
NP_001186776 (OMIM: 605568) E3 ubiquitin-protein l ( 728) 3160 492.9  2e-138
XP_016868486 (OMIM: 602307) PREDICTED: NEDD4-like  ( 719) 1475 236.9 2.2e-61
XP_011515104 (OMIM: 602307) PREDICTED: NEDD4-like  ( 898) 1475 237.0 2.6e-61
XP_016868483 (OMIM: 602307) PREDICTED: NEDD4-like  ( 898) 1475 237.0 2.6e-61
XP_006722487 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 790) 1460 234.7 1.1e-60
XP_016881165 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 856) 1460 234.7 1.2e-60
XP_006722493 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 872) 1460 234.7 1.2e-60
XP_006722484 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 940) 1460 234.8 1.3e-60
XP_005266715 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 960) 1460 234.8 1.3e-60
XP_016881167 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 973) 1460 234.8 1.3e-60
XP_006722491 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 993) 1460 234.8 1.3e-60
XP_011524189 (OMIM: 606384) PREDICTED: E3 ubiquiti (1011) 1460 234.8 1.4e-60
XP_006722489 (OMIM: 606384) PREDICTED: E3 ubiquiti (1019) 1460 234.8 1.4e-60
XP_005260627 (OMIM: 606409,613385) PREDICTED: E3 u ( 692) 1403 226.0 4.2e-58
XP_011527381 (OMIM: 606409,613385) PREDICTED: E3 u ( 692) 1403 226.0 4.2e-58
NP_001244067 (OMIM: 606409,613385) E3 ubiquitin-pr ( 752) 1403 226.0 4.5e-58
XP_016883580 (OMIM: 606409,613385) PREDICTED: E3 u ( 752) 1403 226.0 4.5e-58
NP_001311127 (OMIM: 606409,613385) E3 ubiquitin-pr ( 862) 1403 226.1 4.9e-58
NP_113671 (OMIM: 606409,613385) E3 ubiquitin-prote ( 862) 1403 226.1 4.9e-58
XP_016883579 (OMIM: 606409,613385) PREDICTED: E3 u ( 900) 1403 226.1 5.1e-58
XP_016883578 (OMIM: 606409,613385) PREDICTED: E3 u ( 903) 1403 226.1 5.1e-58
NP_001244066 (OMIM: 606409,613385) E3 ubiquitin-pr ( 903) 1403 226.1 5.1e-58
NP_001311126 (OMIM: 606409,613385) E3 ubiquitin-pr ( 903) 1403 226.1 5.1e-58
NP_955456 (OMIM: 602308) NEDD4-like E3 ubiquitin-p ( 431) 1375 221.5 5.7e-57
NP_001257382 (OMIM: 602308) NEDD4-like E3 ubiquiti ( 754) 1375 221.8 8.5e-57
XP_011521128 (OMIM: 602308) PREDICTED: NEDD4-like  ( 754) 1375 221.8 8.5e-57
NP_001257383 (OMIM: 602308) NEDD4-like E3 ubiquiti ( 870) 1375 221.8 9.4e-57
XP_011521127 (OMIM: 602308) PREDICTED: NEDD4-like  ( 870) 1375 221.8 9.4e-57
XP_011521125 (OMIM: 602308) PREDICTED: NEDD4-like  ( 870) 1375 221.8 9.4e-57
XP_016878369 (OMIM: 602308) PREDICTED: NEDD4-like  ( 870) 1375 221.8 9.4e-57
XP_016878370 (OMIM: 602308) PREDICTED: NEDD4-like  ( 870) 1375 221.8 9.4e-57
NP_008945 (OMIM: 602308) NEDD4-like E3 ubiquitin-p ( 870) 1375 221.8 9.4e-57
XP_016878368 (OMIM: 602308) PREDICTED: NEDD4-like  ( 870) 1375 221.8 9.4e-57
XP_016868484 (OMIM: 602307) PREDICTED: NEDD4-like  ( 743) 1368 220.7 1.8e-56
XP_016868485 (OMIM: 602307) PREDICTED: NEDD4-like  ( 743) 1368 220.7 1.8e-56
XP_005250818 (OMIM: 602307) PREDICTED: NEDD4-like  ( 921) 1368 220.8 2.1e-56
XP_016868482 (OMIM: 602307) PREDICTED: NEDD4-like  ( 921) 1368 220.8 2.1e-56
XP_005250817 (OMIM: 602307) PREDICTED: NEDD4-like  ( 922) 1368 220.8 2.1e-56
NP_008944 (OMIM: 602307) NEDD4-like E3 ubiquitin-p ( 922) 1368 220.8 2.1e-56
XP_016881170 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 684) 1348 217.6 1.4e-55
XP_016881169 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 750) 1348 217.7 1.5e-55
XP_006722488 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 772) 1348 217.7 1.5e-55
NP_001138442 (OMIM: 606384) E3 ubiquitin-protein l ( 834) 1348 217.7 1.6e-55
NP_001138443 (OMIM: 606384) E3 ubiquitin-protein l ( 834) 1348 217.7 1.6e-55


>>NP_065162 (OMIM: 605568) E3 ubiquitin-protein ligase S  (757 aa)
 initn: 5212 init1: 5212 opt: 5212  Z-score: 4290.7  bits: 804.6 E(85289):    0
Smith-Waterman score: 5212; 100.0% identity (100.0% similar) in 757 aa overlap (1-757:1-757)

               10        20        30        40        50        60
pF1KA1 MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDP
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA1 KWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 KWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCK
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA1 LNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 LNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPA
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA1 PYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 PYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGY
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA1 EQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 EQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSV
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA1 NCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 NCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPS
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA1 EGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 EGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMR
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KA1 PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSS
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KA1 INPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 INPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLV
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KA1 WILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 WILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGI
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KA1 EAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 EAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVR
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KA1 WFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 WFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLP
              670       680       690       700       710       720

              730       740       750       
pF1KA1 KAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE
       :::::::::::::::::::::::::::::::::::::
NP_065 KAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE
              730       740       750       

>>XP_016867946 (OMIM: 605568) PREDICTED: E3 ubiquitin-pr  (754 aa)
 initn: 4820 init1: 4820 opt: 5178  Z-score: 4262.8  bits: 799.5 E(85289):    0
Smith-Waterman score: 5178; 99.6% identity (99.6% similar) in 757 aa overlap (1-757:1-754)

               10        20        30        40        50        60
pF1KA1 MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDP
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA1 KWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCK
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA1 LNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPA
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA1 PYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGY
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA1 EQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSV
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA1 NCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPS
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA1 EGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMR
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KA1 PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSS
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KA1 INPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 INPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLV
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KA1 WILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGI
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KA1 EAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVR
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KA1 WFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLP
       :::::::::::::::::::::::::::::::::::::   ::::::::::::::::::::
XP_016 WFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQG---AAGPRLFTIHLIDANTDNLP
              670       680       690          700       710       

              730       740       750       
pF1KA1 KAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE
       :::::::::::::::::::::::::::::::::::::
XP_016 KAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE
       720       730       740       750    

>>NP_073576 (OMIM: 605532) E3 ubiquitin-protein ligase S  (748 aa)
 initn: 3320 init1: 1983 opt: 3539  Z-score: 2917.3  bits: 550.5 E(85289): 9.4e-156
Smith-Waterman score: 3813; 72.3% identity (83.1% similar) in 792 aa overlap (1-757:1-748)

               10        20        30        40        50        60
pF1KA1 MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDP
       ::::: ::::  .:.::::::::::.:::::::::::::.::::::::::::::::::::
NP_073 MSNPGGRRNGP-VKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDP
               10         20        30        40        50         

               70        80        90       100       110       120
pF1KA1 KWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCK
       :::::::::.::.::.:::::::::::::::::::::::::::::.::::::::::::::
NP_073 KWNQHYDLYIGKSDSVTISVWNHKKIHKKQGAGFLGCVRLLSNAINRLKDTGYQRLDLCK
      60        70        80        90       100       110         

              130       140       150                   160        
pF1KA1 LNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENE------------GTVY-----
       :.:.:.:.::::::::::.::::::::.::::  :..:.            : .      
NP_073 LGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHI
     120       130       140       150       160       170         

                         170       180       190       200         
pF1KA1 --------------EDSGPGRPLSCFMEEPAPYTDSTGAAAGGGNCRFVESPSQDQRLQA
                     : :.::::::::..: .: . ..::. :          :.: ::  
NP_073 TRTTQWERPTRPASEYSSPGRPLSCFVDENTPISGTNGATCG---------QSSDPRLAE
     180       190       200       210       220                230

     210       220       230       240       250       260         
pF1KA1 QRLRNPDVRGSLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPS
       .:.:.   :. .    .: : :  :.:::::::::: ::::::::::::::::::::.: 
NP_073 RRVRSQRHRNYM----SRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVP-
              240           250       260       270       280      

     270       280       290       300       310       320         
pF1KA1 PSGTIPGGDAAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNN
                                :::...::.::::::::::.:.:..::.:::::::
NP_073 -------------------------RDLSNINCEELGPLPPGWEIRNTATGRVYFVDHNN
                                  290       300       310       320

     330           340       350       360       370       380     
pF1KA1 RTTQFTDPRL----HHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVL
       ::::::::::    : ..:.: :::. .:   . :    . : : . ::.::::::::.:
NP_073 RTTQFTDPRLSANLHLVLNRQNQLKDQQQQ-QVVSLCPDDTECLTVPRYKRDLVQKLKIL
              330       340       350        360       370         

         390       400       410       420       430       440     
pF1KA1 RHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAR
       :.::: ::::::::::::::::::::::::.:::::::: ::::.:::::::::::::::
NP_073 RQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAR
     380       390       400       410       420       430         

         450       460       470       480       490       500     
pF1KA1 EWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHY
       :::::: :::::::::::::: :.:: :::::::..::.:::::::::::::.:::::::
NP_073 EWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHY
     440       450       460       470       480       490         

         510       520       530       540       550       560     
pF1KA1 INGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRI
       :.::::.::::::::: : :.:.: :::.::.::::::::::: ::::::::::::.:.:
NP_073 IDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGVLDHTFCVEHNAYGEI
     500       510       520       530       540       550         

         570       580       590       600       610       620     
pF1KA1 LQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQ
       .::::::::...::.::::::::::::::::.::::::::::::::::.::::::: ::.
NP_073 IQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDE
     560       570       580       590       600       610         

         630       640       650       660       670       680     
pF1KA1 KELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGST
       ::::::: :: :::.:::: :::::::. :::::.:::.::: ::::::::::::::::.
NP_073 KELELIICGLGKIDVNDWKVNTRLKHCTPDSNIVKWFWKAVEFFDEERRARLLQFVTGSS
     620       630       640       650       660       670         

         690       700       710       720       730       740     
pF1KA1 RVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLL
       ::::::::::::   :::::::::: ::: :.::::::::::::::::::::::::::::
NP_073 RVPLQGFKALQG---AAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLL
     680       690          700       710       720       730      

         750       
pF1KA1 TAVEETCGFAVE
       ::.:::::::::
NP_073 TAIEETCGFAVE
        740        

>>XP_011523430 (OMIM: 605532) PREDICTED: E3 ubiquitin-pr  (750 aa)
 initn: 3286 init1: 1983 opt: 3465  Z-score: 2856.5  bits: 539.2 E(85289): 2.3e-152
Smith-Waterman score: 3739; 71.1% identity (82.6% similar) in 793 aa overlap (1-757:1-750)

               10         20        30        40        50         
pF1KA1 MSNPGTRRNGSSIKIRLT-VLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLD
       :.  . :...:.. . :  :::::::.:::::::::::::.:::::::::::::::::::
XP_011 MGLSSCRKTSSGLPLILHYVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLD
               10        20        30        40        50        60

      60        70        80        90       100       110         
pF1KA1 PKWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLC
       ::::::::::.::.::.:::::::::::::::::::::::::::::.:::::::::::::
XP_011 PKWNQHYDLYIGKSDSVTISVWNHKKIHKKQGAGFLGCVRLLSNAINRLKDTGYQRLDLC
               70        80        90       100       110       120

     120       130       140       150                   160       
pF1KA1 KLNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENE------------GTVY----
       ::.:.:.:.::::::::::.::::::::.::::  :..:.            : .     
XP_011 KLGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNH
              130       140       150       160       170       180

                          170       180       190       200        
pF1KA1 ---------------EDSGPGRPLSCFMEEPAPYTDSTGAAAGGGNCRFVESPSQDQRLQ
                      : :.::::::::..: .: . ..::. :          :.: :: 
XP_011 ITRTTQWERPTRPASEYSSPGRPLSCFVDENTPISGTNGATCG---------QSSDPRLA
              190       200       210       220                230 

      210       220       230       240       250       260        
pF1KA1 AQRLRNPDVRGSLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIP
        .:.:.   :. .    .: : :  :.:::::::::: ::::::::::::::::::::.:
XP_011 ERRVRSQRHRNYM----SRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVP
             240           250       260       270       280       

      270       280       290       300       310       320        
pF1KA1 SPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHN
                                 :::...::.::::::::::.:.:..::.::::::
XP_011 --------------------------RDLSNINCEELGPLPPGWEIRNTATGRVYFVDHN
                                 290       300       310       320 

      330           340       350       360       370       380    
pF1KA1 NRTTQFTDPRL----HHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKV
       :::::::::::    : ..:.: :::. .:   . :    . : : . ::.::::::::.
XP_011 NRTTQFTDPRLSANLHLVLNRQNQLKDQQQQ-QVVSLCPDDTECLTVPRYKRDLVQKLKI
             330       340       350        360       370       380

          390       400       410       420       430       440    
pF1KA1 LRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVA
       ::.::: ::::::::::::::::::::::::.:::::::: ::::.::::::::::::::
XP_011 LRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVA
              390       400       410       420       430       440

          450       460       470       480       490       500    
pF1KA1 REWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGH
       ::::::: :::::::::::::: :.:: :::::::..::.:::::::::::::.::::::
XP_011 REWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGH
              450       460       470       480       490       500

          510       520       530       540       550       560    
pF1KA1 YINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGR
       ::.::::.::::::::: : :.:.: :::.::.::::::::::: ::::::::::::.:.
XP_011 YIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGVLDHTFCVEHNAYGE
              510       520       530       540       550       560

          570       580       590       600       610       620    
pF1KA1 ILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFD
       :.::::::::...::.::::::::::::::::.::::::::::::::::.::::::: ::
XP_011 IIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFD
              570       580       590       600       610       620

          630       640       650       660       670       680    
pF1KA1 QKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGS
       .::::::: :: :::.:::: :::::::. :::::.:::.::: ::::::::::::::::
XP_011 EKELELIICGLGKIDVNDWKVNTRLKHCTPDSNIVKWFWKAVEFFDEERRARLLQFVTGS
              630       640       650       660       670       680

          690       700       710       720       730       740    
pF1KA1 TRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKL
       .::::::::::::   :::::::::: ::: :.:::::::::::::::::::::::::::
XP_011 SRVPLQGFKALQG---AAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKL
              690          700       710       720       730       

          750       
pF1KA1 LTAVEETCGFAVE
       :::.:::::::::
XP_011 LTAIEETCGFAVE
       740       750

>>XP_005257642 (OMIM: 605532) PREDICTED: E3 ubiquitin-pr  (735 aa)
 initn: 3247 init1: 1983 opt: 3370  Z-score: 2778.6  bits: 524.8 E(85289): 4.9e-148
Smith-Waterman score: 3685; 70.7% identity (81.3% similar) in 792 aa overlap (1-757:1-735)

               10        20        30        40        50        60
pF1KA1 MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDP
       ::::: ::::  .:.:::              :::::::.::::::::::::::::::::
XP_005 MSNPGGRRNGP-VKLRLT-------------GLPDPFAKVVVDGSGQCHSTDTVKNTLDP
               10                      20        30        40      

               70        80        90       100       110       120
pF1KA1 KWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCK
       :::::::::.::.::.:::::::::::::::::::::::::::::.::::::::::::::
XP_005 KWNQHYDLYIGKSDSVTISVWNHKKIHKKQGAGFLGCVRLLSNAINRLKDTGYQRLDLCK
         50        60        70        80        90       100      

              130       140       150                   160        
pF1KA1 LNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENE------------GTVY-----
       :.:.:.:.::::::::::.::::::::.::::  :..:.            : .      
XP_005 LGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHI
        110       120       130       140       150       160      

                         170       180       190       200         
pF1KA1 --------------EDSGPGRPLSCFMEEPAPYTDSTGAAAGGGNCRFVESPSQDQRLQA
                     : :.::::::::..: .: . ..::. :          :.: ::  
XP_005 TRTTQWERPTRPASEYSSPGRPLSCFVDENTPISGTNGATCG---------QSSDPRLAE
        170       180       190       200                210       

     210       220       230       240       250       260         
pF1KA1 QRLRNPDVRGSLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPS
       .:.:.   :. .    .: : :  :.:::::::::: ::::::::::::::::::::.: 
XP_005 RRVRSQRHRNYM----SRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVP-
       220           230       240       250       260       270   

     270       280       290       300       310       320         
pF1KA1 PSGTIPGGDAAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNN
                                :::...::.::::::::::.:.:..::.:::::::
XP_005 -------------------------RDLSNINCEELGPLPPGWEIRNTATGRVYFVDHNN
                                     280       290       300       

     330           340       350       360       370       380     
pF1KA1 RTTQFTDPRL----HHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVL
       ::::::::::    : ..:.: :::. .:   . :    . : : . ::.::::::::.:
XP_005 RTTQFTDPRLSANLHLVLNRQNQLKDQQQQ-QVVSLCPDDTECLTVPRYKRDLVQKLKIL
       310       320       330        340       350       360      

         390       400       410       420       430       440     
pF1KA1 RHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAR
       :.::: ::::::::::::::::::::::::.:::::::: ::::.:::::::::::::::
XP_005 RQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAR
        370       380       390       400       410       420      

         450       460       470       480       490       500     
pF1KA1 EWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHY
       :::::: :::::::::::::: :.:: :::::::..::.:::::::::::::.:::::::
XP_005 EWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHY
        430       440       450       460       470       480      

         510       520       530       540       550       560     
pF1KA1 INGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRI
       :.::::.::::::::: : :.:.: :::.::.::::::::::: ::::::::::::.:.:
XP_005 IDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGVLDHTFCVEHNAYGEI
        490       500       510       520       530       540      

         570       580       590       600       610       620     
pF1KA1 LQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQ
       .::::::::...::.::::::::::::::::.::::::::::::::::.::::::: ::.
XP_005 IQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDE
        550       560       570       580       590       600      

         630       640       650       660       670       680     
pF1KA1 KELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGST
       ::::::: :: :::.:::: :::::::. :::::.:::.::: ::::::::::::::::.
XP_005 KELELIICGLGKIDVNDWKVNTRLKHCTPDSNIVKWFWKAVEFFDEERRARLLQFVTGSS
        610       620       630       640       650       660      

         690       700       710       720       730       740     
pF1KA1 RVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLL
       ::::::::::::   :::::::::: ::: :.::::::::::::::::::::::::::::
XP_005 RVPLQGFKALQG---AAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLL
        670          680       690       700       710       720   

         750       
pF1KA1 TAVEETCGFAVE
       ::.:::::::::
XP_005 TAIEETCGFAVE
           730     

>>NP_851994 (OMIM: 605568) E3 ubiquitin-protein ligase S  (731 aa)
 initn: 3194 init1: 3194 opt: 3194  Z-score: 2634.2  bits: 498.1 E(85289): 5.5e-140
Smith-Waterman score: 4972; 96.6% identity (96.6% similar) in 757 aa overlap (1-757:1-731)

               10        20        30        40        50        60
pF1KA1 MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_851 MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDP
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA1 KWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_851 KWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCK
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA1 LNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_851 LNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPA
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA1 PYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_851 PYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGY
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA1 EQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSV
       ::::::::::::::::::::::::::::                          ::::::
NP_851 EQRTTVQGQVYFLHTQTGVSTWHDPRIP--------------------------RDLNSV
              250       260                                 270    

              310       320       330       340       350       360
pF1KA1 NCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_851 NCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPS
          280       290       300       310       320       330    

              370       380       390       400       410       420
pF1KA1 EGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_851 EGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMR
          340       350       360       370       380       390    

              430       440       450       460       470       480
pF1KA1 PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_851 PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSS
          400       410       420       430       440       450    

              490       500       510       520       530       540
pF1KA1 INPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_851 INPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLV
          460       470       480       490       500       510    

              550       560       570       580       590       600
pF1KA1 WILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_851 WILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGI
          520       530       540       550       560       570    

              610       620       630       640       650       660
pF1KA1 EAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_851 EAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVR
          580       590       600       610       620       630    

              670       680       690       700       710       720
pF1KA1 WFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_851 WFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLP
          640       650       660       670       680       690    

              730       740       750       
pF1KA1 KAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE
       :::::::::::::::::::::::::::::::::::::
NP_851 KAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE
          700       710       720       730 

>>NP_001186776 (OMIM: 605568) E3 ubiquitin-protein ligas  (728 aa)
 initn: 2802 init1: 2802 opt: 3160  Z-score: 2606.3  bits: 492.9 E(85289): 2e-138
Smith-Waterman score: 4938; 96.2% identity (96.2% similar) in 757 aa overlap (1-757:1-728)

               10        20        30        40        50        60
pF1KA1 MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDP
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA1 KWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCK
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA1 LNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPA
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA1 PYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGY
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA1 EQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSV
       ::::::::::::::::::::::::::::                          ::::::
NP_001 EQRTTVQGQVYFLHTQTGVSTWHDPRIP--------------------------RDLNSV
              250       260                                 270    

              310       320       330       340       350       360
pF1KA1 NCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPS
          280       290       300       310       320       330    

              370       380       390       400       410       420
pF1KA1 EGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMR
          340       350       360       370       380       390    

              430       440       450       460       470       480
pF1KA1 PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSS
          400       410       420       430       440       450    

              490       500       510       520       530       540
pF1KA1 INPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 INPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLV
          460       470       480       490       500       510    

              550       560       570       580       590       600
pF1KA1 WILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGI
          520       530       540       550       560       570    

              610       620       630       640       650       660
pF1KA1 EAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVR
          580       590       600       610       620       630    

              670       680       690       700       710       720
pF1KA1 WFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLP
       :::::::::::::::::::::::::::::::::::::   ::::::::::::::::::::
NP_001 WFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQG---AAGPRLFTIHLIDANTDNLP
          640       650       660       670          680       690 

              730       740       750       
pF1KA1 KAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE
       :::::::::::::::::::::::::::::::::::::
NP_001 KAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE
             700       710       720        

>>XP_016868486 (OMIM: 602307) PREDICTED: NEDD4-like E3 u  (719 aa)
 initn: 1515 init1: 602 opt: 1475  Z-score: 1223.0  bits: 236.9 E(85289): 2.2e-61
Smith-Waterman score: 1502; 40.1% identity (66.5% similar) in 633 aa overlap (156-757:124-719)

         130       140       150       160         170             
pF1KA1 TDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEG-TVYE-DSGPGRPLSCFM----EEP
                                     ::.:. .. : :.. .:  : :     ..:
XP_016 CTSTTVEDPPVQEILTSSENNECIPSTSAELESEARSILEPDTSNSRSSSAFEAAKSRQP
           100       110       120       130       140       150   

     180       190       200       210       220       230         
pF1KA1 APYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPE-LPE
           : .   .:..: . . : . .::      ..:  :      ..:    . :. :: 
XP_016 DGCMDPVRQQSGNANTETLPS-GWEQR------KDPHGRTYYVDHNTRTTTWERPQPLPP
           160       170              180       190       200      

      240       250       260                270       280         
pF1KA1 GYEQRTTVQGQVYFLHTQTGVSTWHDPRIPS---------PSGTIPGGDAAFLYEFLLQG
       :.:.:.  . .::..  .: ..::. : . :           . . :.   :  ..: ..
XP_016 GWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRYLYSA
        210       220       230       240       250       260      

     290       300       310       320       330       340         
pF1KA1 HTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQL
             .. ... :  :::::::: :   . :.:::.::..:::. ::: . ..:..   
XP_016 ------SMLAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQGLQNEE---
              270       280       290       300       310          

     350       360       370       380          390       400      
pF1KA1 KEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHEL---SLQQPQAGHCRIEVSRE
              :::     :  :.   :: :. :. .  . :.    ....:. :.  .  .  
XP_016 -------PLP-----EGWEI---RYTREGVRYF--VDHNTRTTTFKDPRNGKSSVTKGGP
              320               330         340       350       360

         410                 420       430       440       450     
pF1KA1 EI-FEESYR----------QIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEM
       .: .:...:          ::: ..: ::..::.: :::::::::::.::::..:: ::.
XP_016 QIAYERGFRWKLAHFRYLCQIMALKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEV
              370       380       390       400       410       420

         460       470       480       490       500       510     
pF1KA1 LNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFY
       :::.: ::.:.  : : ::::: :.::::::::: :.::....:.:::..:. ::..:::
XP_016 LNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFY
              430       440       450       460       470       480

         520       530       540       550        560       570    
pF1KA1 KQLLGKPIQLSDLESVDPELHKSLVWILENDITPV-LDHTFCVEHNAFGRILQHELKPNG
       :..:.: . ..::::.: :...::.:: .:.:    :.  : :. . .:.. .:.:: .:
XP_016 KRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGLEMYFSVDMEILGKVTSHDLKLGG
              490       500       510       520       530       540

          580       590       600       610       620       630    
pF1KA1 RNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGG
        :. :::::: ::. :...::: ::.. :  :.  ::::..: . :. ::.::::... :
XP_016 SNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCG
              550       560       570       580       590       600

          640       650       660       670       680       690    
pF1KA1 LDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKA
       ....:: ::. ::  .: . .:. . :::: :.  :.: : ::::::::. :.:: ::  
XP_016 MQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAE
              610       620       630       640       650       660

          700       710       720       730       740       750    
pF1KA1 LQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGF
       :.::.:   :. : :. .  .:  ::..::::::.:.:::.:::.: :::: :.::: ::
XP_016 LMGSNG---PQKFCIEKVGKDT-WLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF
                 670        680       690       700       710      

          
pF1KA1 AVE
       . :
XP_016 GQE
          

>>XP_011515104 (OMIM: 602307) PREDICTED: NEDD4-like E3 u  (898 aa)
 initn: 1515 init1: 602 opt: 1475  Z-score: 1221.8  bits: 237.0 E(85289): 2.6e-61
Smith-Waterman score: 1502; 40.1% identity (66.5% similar) in 633 aa overlap (156-757:303-898)

         130       140       150       160         170             
pF1KA1 TDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEG-TVYE-DSGPGRPLSCFM----EEP
                                     ::.:. .. : :.. .:  : :     ..:
XP_011 CTSTTVEDPPVQEILTSSENNECIPSTSAELESEARSILEPDTSNSRSSSAFEAAKSRQP
            280       290       300       310       320       330  

     180       190       200       210       220       230         
pF1KA1 APYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPE-LPE
           : .   .:..: . . : . .::      ..:  :      ..:    . :. :: 
XP_011 DGCMDPVRQQSGNANTETLPS-GWEQR------KDPHGRTYYVDHNTRTTTWERPQPLPP
            340       350              360       370       380     

      240       250       260                270       280         
pF1KA1 GYEQRTTVQGQVYFLHTQTGVSTWHDPRIPS---------PSGTIPGGDAAFLYEFLLQG
       :.:.:.  . .::..  .: ..::. : . :           . . :.   :  ..: ..
XP_011 GWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRYLYSA
         390       400       410       420       430       440     

     290       300       310       320       330       340         
pF1KA1 HTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQL
             .. ... :  :::::::: :   . :.:::.::..:::. ::: . ..:..   
XP_011 ------SMLAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQGLQNEE---
               450       460       470       480       490         

     350       360       370       380          390       400      
pF1KA1 KEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHEL---SLQQPQAGHCRIEVSRE
              :::     :  :.   :: :. :. .  . :.    ....:. :.  .  .  
XP_011 -------PLP-----EGWEI---RYTREGVRYF--VDHNTRTTTFKDPRNGKSSVTKGGP
                    500          510         520       530         

         410                 420       430       440       450     
pF1KA1 EI-FEESYR----------QIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEM
       .: .:...:          ::: ..: ::..::.: :::::::::::.::::..:: ::.
XP_011 QIAYERGFRWKLAHFRYLCQIMALKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEV
     540       550       560       570       580       590         

         460       470       480       490       500       510     
pF1KA1 LNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFY
       :::.: ::.:.  : : ::::: :.::::::::: :.::....:.:::..:. ::..:::
XP_011 LNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFY
     600       610       620       630       640       650         

         520       530       540       550        560       570    
pF1KA1 KQLLGKPIQLSDLESVDPELHKSLVWILENDITPV-LDHTFCVEHNAFGRILQHELKPNG
       :..:.: . ..::::.: :...::.:: .:.:    :.  : :. . .:.. .:.:: .:
XP_011 KRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGLEMYFSVDMEILGKVTSHDLKLGG
     660       670       680       690       700       710         

          580       590       600       610       620       630    
pF1KA1 RNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGG
        :. :::::: ::. :...::: ::.. :  :.  ::::..: . :. ::.::::... :
XP_011 SNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCG
     720       730       740       750       760       770         

          640       650       660       670       680       690    
pF1KA1 LDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKA
       ....:: ::. ::  .: . .:. . :::: :.  :.: : ::::::::. :.:: ::  
XP_011 MQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAE
     780       790       800       810       820       830         

          700       710       720       730       740       750    
pF1KA1 LQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGF
       :.::.:   :. : :. .  .:  ::..::::::.:.:::.:::.: :::: :.::: ::
XP_011 LMGSNG---PQKFCIEKVGKDT-WLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF
     840          850        860       870       880       890     

          
pF1KA1 AVE
       . :
XP_011 GQE
          

>>XP_016868483 (OMIM: 602307) PREDICTED: NEDD4-like E3 u  (898 aa)
 initn: 1515 init1: 602 opt: 1475  Z-score: 1221.8  bits: 237.0 E(85289): 2.6e-61
Smith-Waterman score: 1502; 40.1% identity (66.5% similar) in 633 aa overlap (156-757:303-898)

         130       140       150       160         170             
pF1KA1 TDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEG-TVYE-DSGPGRPLSCFM----EEP
                                     ::.:. .. : :.. .:  : :     ..:
XP_016 CTSTTVEDPPVQEILTSSENNECIPSTSAELESEARSILEPDTSNSRSSSAFEAAKSRQP
            280       290       300       310       320       330  

     180       190       200       210       220       230         
pF1KA1 APYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPE-LPE
           : .   .:..: . . : . .::      ..:  :      ..:    . :. :: 
XP_016 DGCMDPVRQQSGNANTETLPS-GWEQR------KDPHGRTYYVDHNTRTTTWERPQPLPP
            340       350              360       370       380     

      240       250       260                270       280         
pF1KA1 GYEQRTTVQGQVYFLHTQTGVSTWHDPRIPS---------PSGTIPGGDAAFLYEFLLQG
       :.:.:.  . .::..  .: ..::. : . :           . . :.   :  ..: ..
XP_016 GWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRYLYSA
         390       400       410       420       430       440     

     290       300       310       320       330       340         
pF1KA1 HTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQL
             .. ... :  :::::::: :   . :.:::.::..:::. ::: . ..:..   
XP_016 ------SMLAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQGLQNEE---
               450       460       470       480       490         

     350       360       370       380          390       400      
pF1KA1 KEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHEL---SLQQPQAGHCRIEVSRE
              :::     :  :.   :: :. :. .  . :.    ....:. :.  .  .  
XP_016 -------PLP-----EGWEI---RYTREGVRYF--VDHNTRTTTFKDPRNGKSSVTKGGP
                    500          510         520       530         

         410                 420       430       440       450     
pF1KA1 EI-FEESYR----------QIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEM
       .: .:...:          ::: ..: ::..::.: :::::::::::.::::..:: ::.
XP_016 QIAYERGFRWKLAHFRYLCQIMALKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEV
     540       550       560       570       580       590         

         460       470       480       490       500       510     
pF1KA1 LNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFY
       :::.: ::.:.  : : ::::: :.::::::::: :.::....:.:::..:. ::..:::
XP_016 LNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFY
     600       610       620       630       640       650         

         520       530       540       550        560       570    
pF1KA1 KQLLGKPIQLSDLESVDPELHKSLVWILENDITPV-LDHTFCVEHNAFGRILQHELKPNG
       :..:.: . ..::::.: :...::.:: .:.:    :.  : :. . .:.. .:.:: .:
XP_016 KRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGLEMYFSVDMEILGKVTSHDLKLGG
     660       670       680       690       700       710         

          580       590       600       610       620       630    
pF1KA1 RNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGG
        :. :::::: ::. :...::: ::.. :  :.  ::::..: . :. ::.::::... :
XP_016 SNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCG
     720       730       740       750       760       770         

          640       650       660       670       680       690    
pF1KA1 LDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKA
       ....:: ::. ::  .: . .:. . :::: :.  :.: : ::::::::. :.:: ::  
XP_016 MQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAE
     780       790       800       810       820       830         

          700       710       720       730       740       750    
pF1KA1 LQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGF
       :.::.:   :. : :. .  .:  ::..::::::.:.:::.:::.: :::: :.::: ::
XP_016 LMGSNG---PQKFCIEKVGKDT-WLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF
     840          850        860       870       880       890     

          
pF1KA1 AVE
       . :
XP_016 GQE
          




757 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Wed Nov  2 21:35:25 2016 done: Wed Nov  2 21:35:27 2016
 Total Scan time: 10.980 Total Display time:  0.160

Function used was FASTA [36.3.4 Apr, 2011]
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