Result of FASTA (omim) for pF1KA0321
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KA0321, 2539 aa
  1>>>pF1KA0321 2539 - 2539 aa - 2539 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 7.9173+/-0.000435; mu= 14.1110+/- 0.027
 mean_var=147.6979+/-30.365, 0's: 0 Z-trim(115.7): 136  B-trim: 348 in 1/54
 Lambda= 0.105533
 statistics sampled from 26182 (26331) to 26182 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.648), E-opt: 0.2 (0.309), width:  16
 Scan time: 24.400

The best scores are:                                      opt bits E(85289)
NP_056161 (OMIM: 270700,612012) zinc finger FYVE d (2539) 17027 2605.9       0
XP_016876613 (OMIM: 270700,612012) PREDICTED: zinc (2545) 17005 2602.6       0
XP_016876614 (OMIM: 270700,612012) PREDICTED: zinc (2503) 16564 2535.4       0
XP_016876615 (OMIM: 270700,612012) PREDICTED: zinc (2042) 13531 2073.6       0
XP_016876616 (OMIM: 270700,612012) PREDICTED: zinc (1770) 11685 1792.5       0
XP_016876617 (OMIM: 270700,612012) PREDICTED: zinc (1739) 11511 1766.0       0
XP_011534911 (OMIM: 270700,612012) PREDICTED: zinc (1666) 11130 1708.0       0
XP_011525611 (OMIM: 615200) PREDICTED: pleckstrin  ( 279)  283 56.1 7.8e-07
NP_077286 (OMIM: 615200) pleckstrin homology domai ( 279)  283 56.1 7.8e-07
XP_005259313 (OMIM: 615200) PREDICTED: pleckstrin  ( 364)  283 56.2 9.7e-07
NP_078889 (OMIM: 615208) pleckstrin homology domai ( 249)  273 54.6   2e-06
NP_060821 (OMIM: 613520) FYVE, RhoGEF and PH domai (1430)  268 54.2 1.5e-05
NP_775829 (OMIM: 605091) FYVE, RhoGEF and PH domai ( 655)  233 48.7 0.00031
NP_001098721 (OMIM: 608880) zinc finger FYVE domai (1539)  233 48.9 0.00063
NP_055548 (OMIM: 608880) zinc finger FYVE domain-c (1539)  233 48.9 0.00063
XP_016865580 (OMIM: 608880) PREDICTED: zinc finger (1539)  233 48.9 0.00063
XP_011542055 (OMIM: 608880) PREDICTED: zinc finger (1539)  233 48.9 0.00063
XP_005248689 (OMIM: 608880) PREDICTED: zinc finger (1539)  233 48.9 0.00063
XP_016865581 (OMIM: 608880) PREDICTED: zinc finger (1539)  233 48.9 0.00063
NP_001271165 (OMIM: 608880) zinc finger FYVE domai (1539)  233 48.9 0.00063
NP_001271166 (OMIM: 608880) zinc finger FYVE domai ( 809)  227 47.8  0.0007
XP_016863994 (OMIM: 614176) PREDICTED: lateral sig ( 773)  219 46.6  0.0016
NP_001166130 (OMIM: 614176) lateral signaling targ ( 817)  219 46.6  0.0016
NP_001166127 (OMIM: 614176) lateral signaling targ ( 857)  219 46.6  0.0017
NP_066023 (OMIM: 614176) lateral signaling target  ( 887)  219 46.6  0.0017
XP_016865384 (OMIM: 610327) PREDICTED: RUN and FYV ( 310)  210 45.0  0.0019
XP_016865383 (OMIM: 610327) PREDICTED: RUN and FYV ( 368)  210 45.1  0.0022
XP_006714985 (OMIM: 610327) PREDICTED: RUN and FYV ( 368)  210 45.1  0.0022
XP_016865382 (OMIM: 610327) PREDICTED: RUN and FYV ( 416)  210 45.1  0.0024
XP_016865381 (OMIM: 610327) PREDICTED: RUN and FYV ( 438)  210 45.1  0.0025
NP_076976 (OMIM: 613504) zinc finger FYVE domain-c ( 234)  205 44.2  0.0025
XP_005266050 (OMIM: 610327) PREDICTED: RUN and FYV ( 465)  210 45.1  0.0026
NP_001185882 (OMIM: 613504) zinc finger FYVE domai ( 252)  205 44.2  0.0027
XP_016865380 (OMIM: 610327) PREDICTED: RUN and FYV ( 578)  210 45.2  0.0032
NP_001035542 (OMIM: 610327) RUN and FYVE domain-co ( 600)  210 45.2  0.0033
NP_001035541 (OMIM: 610327) RUN and FYVE domain-co ( 600)  210 45.2  0.0033
XP_006714984 (OMIM: 610327) PREDICTED: RUN and FYV ( 686)  210 45.2  0.0036
NP_079434 (OMIM: 610327) RUN and FYVE domain-conta ( 708)  210 45.2  0.0037
XP_016880786 (OMIM: 604375) PREDICTED: hepatocyte  ( 768)  209 45.1  0.0045
XP_011523765 (OMIM: 604375) PREDICTED: hepatocyte  ( 777)  209 45.1  0.0045
NP_004703 (OMIM: 604375) hepatocyte growth factor- ( 777)  209 45.1  0.0045
XP_005270014 (OMIM: 610328) PREDICTED: RUN and FYV ( 572)  206 44.6  0.0048
XP_005270013 (OMIM: 610328) PREDICTED: RUN and FYV ( 585)  206 44.6  0.0049
XP_005270012 (OMIM: 610328) PREDICTED: RUN and FYV ( 590)  206 44.6  0.0049
XP_011538244 (OMIM: 610328) PREDICTED: RUN and FYV ( 606)  206 44.6   0.005
NP_001317032 (OMIM: 610328) RUN and FYVE domain-co ( 606)  206 44.6   0.005
XP_005270010 (OMIM: 610328) PREDICTED: RUN and FYV ( 607)  206 44.6   0.005
NP_060457 (OMIM: 610328) RUN and FYVE domain-conta ( 641)  206 44.6  0.0053
XP_016865918 (OMIM: 605091) PREDICTED: FYVE, RhoGE ( 662)  203 44.1  0.0074
XP_016858334 (OMIM: 603755) PREDICTED: zinc finger (1167)  206 44.7  0.0087


>>NP_056161 (OMIM: 270700,612012) zinc finger FYVE domai  (2539 aa)
 initn: 17027 init1: 17027 opt: 17027  Z-score: 14006.9  bits: 2605.9 E(85289):    0
Smith-Waterman score: 17027; 99.9% identity (100.0% similar) in 2539 aa overlap (1-2539:1-2539)

               10        20        30        40        50        60
pF1KA0 MNHPFGKEEAASQKQLFGFFCECLRRGEWELAQACVPQLQEGQGDIPKRVEDILQALVVC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 MNHPFGKEEAASQKQLFGFFCECLRRGEWELAQACVPQLQEGQGDIPKRVEDILQALVVC
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 PNLLRCGQDINPQRVAWVWLLVLEKWLAREKKLLPVVFRRKLEFLLLSEDLQGDIPENIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 PNLLRCGQDINPQRVAWVWLLVLEKWLAREKKLLPVVFRRKLEFLLLSEDLQGDIPENIL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 EELYETLTQGAVGHVPDGNPRRESWTPRLSSEAVSVLWDLLRQSPQPAQALLELLLEEDD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 EELYETLTQGAVGHVPDGNPRRESWTPRLSSEAVSVLWDLLRQSPQPAQALLELLLEEDD
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 GTGLCHWPLQNALVDLIRKALRALQGPDSVPPGVVDAIYGALRTLRCPAEPLGVELHLLC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 GTGLCHWPLQNALVDLIRKALRALQGPDSVPPGVVDAIYGALRTLRCPAEPLGVELHLLC
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA0 EELLEACRTEGSPLREERLLSCLLHKASRGLLSLYGHTYAEKVTEKPPRATASGKVSPDH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 EELLEACRTEGSPLREERLLSCLLHKASRGLLSLYGHTYAEKVTEKPPRATASGKVSPDH
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA0 LDPERAMLALFSNPNPAEAWKVAYFYCLSNNKHFLEQILVTALTLLKEEDFPNLGCLLDR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LDPERAMLALFSNPNPAEAWKVAYFYCLSNNKHFLEQILVTALTLLKEEDFPNLGCLLDR
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA0 EFRPLSCLLVLLGWTHCQSLESAKRLLQTLHRTQGPGCDELLRDACDGLWAHLEVLEWCI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 EFRPLSCLLVLLGWTHCQSLESAKRLLQTLHRTQGPGCDELLRDACDGLWAHLEVLEWCI
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KA0 QQSSNPIPKRDLLYHLHGGDSHSVLYTLHHLTNLPALREEDVLKLLQKVPAKDPQQEPDA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 QQSSNPIPKRDLLYHLHGGDSHSVLYTLHHLTNLPALREEDVLKLLQKVPAKDPQQEPDA
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KA0 VDAPVPEHLSQCQNLTLYQGFCAMKYAIYALCVNSHQHSQCQDCKDSLSEDLASATEPAN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 VDAPVPEHLSQCQNLTLYQGFCAMKYAIYALCVNSHQHSQCQDCKDSLSEDLASATEPAN
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KA0 DSLSSPGAANLFSTYPARCQQYLCSIPDSLCLELLENIFSLLLITSADLHPEPHLPEDYA
       ::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::
NP_056 DSLSSPGAANLFSTYLARCQQYLCSIPDSLCLELLENIFSLLLITSADLHPEPHLPEDYA
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KA0 EDDDIEGKSPSGLRSPSESPQHIAHPERKSERGSLGVPKTLAYTMPSHVKAEPKDSYPGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 EDDDIEGKSPSGLRSPSESPQHIAHPERKSERGSLGVPKTLAYTMPSHVKAEPKDSYPGP
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KA0 HRHSFLDLKHFTSGISGFLADEFAIGAFLRLLQEQLDEISSRSPPEKPKQESQSCSGSRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 HRHSFLDLKHFTSGISGFLADEFAIGAFLRLLQEQLDEISSRSPPEKPKQESQSCSGSRD
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KA0 GLQSRLHRLSKVVSEAQWRHKVVTSNHRSEEQPSRRYQPATRHPSLRRGRRTRRSQADGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 GLQSRLHRLSKVVSEAQWRHKVVTSNHRSEEQPSRRYQPATRHPSLRRGRRTRRSQADGR
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KA0 DRGSNPSLESTSSELSTSTSEGSLSAMSGRNELHSRLHPHPQSSLIPMMFSPPESLLASC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 DRGSNPSLESTSSELSTSTSEGSLSAMSGRNELHSRLHPHPQSSLIPMMFSPPESLLASC
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KA0 ILRGNFAEAHQVLFTFNLKSSPSSGELMFMERYQEVIQELAQVEHKIENQNSDAGSSTIR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 ILRGNFAEAHQVLFTFNLKSSPSSGELMFMERYQEVIQELAQVEHKIENQNSDAGSSTIR
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KA0 RTGSGRSTLQAIGSAAAAGMVFYSISDVTDKLLNTSGDPIPMLQEDFWISTALVEPTAPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 RTGSGRSTLQAIGSAAAAGMVFYSISDVTDKLLNTSGDPIPMLQEDFWISTALVEPTAPL
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KA0 REVLEDLSPPAMAAFDLACSQCQLWKTCKQLLETAERRLNSSLERRGRRIDHVLLNADGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 REVLEDLSPPAMAAFDLACSQCQLWKTCKQLLETAERRLNSSLERRGRRIDHVLLNADGI
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KA0 RGFPVVLQQISKSLNYLLMTASQTKSESVEEKGGGPPRCSITELLQMCWPSLSEDCVASH
       :::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::
NP_056 RGFPVVLQQISKSLNYLLMSASQTKSESVEEKGGGPPRCSITELLQMCWPSLSEDCVASH
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KA0 TTLSQQLDQVLQSLREALELPEPRTPPLSSLVEQAAQKAPEAEAHPVQIQTQLLQKNLGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 TTLSQQLDQVLQSLREALELPEPRTPPLSSLVEQAAQKAPEAEAHPVQIQTQLLQKNLGK
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KA0 QTPSGSRQMDYLGTFFSYCSTLAAVLLQSLSSEPDHVEVKVGNPFVLLQQSSSQLVSHLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 QTPSGSRQMDYLGTFFSYCSTLAAVLLQSLSSEPDHVEVKVGNPFVLLQQSSSQLVSHLL
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KA0 FERQVPPERLAALLAQENLSLSVPQVIVSCCCEPLALCSSRQSQQTSSLLTRLGTLAQLH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 FERQVPPERLAALLAQENLSLSVPQVIVSCCCEPLALCSSRQSQQTSSLLTRLGTLAQLH
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KA0 ASHCLDDLPLSTPSSPRTTENPTLERKPYSSPRDSSLPALTSSALAFLKSRSKLLATVAC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 ASHCLDDLPLSTPSSPRTTENPTLERKPYSSPRDSSLPALTSSALAFLKSRSKLLATVAC
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KA0 LGASPRLKVSKPSLSWKELRGRREVPLAAEQVARECERLLEQFPLFEAFLLAAWEPLRGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LGASPRLKVSKPSLSWKELRGRREVPLAAEQVARECERLLEQFPLFEAFLLAAWEPLRGS
             1330      1340      1350      1360      1370      1380

             1390      1400      1410      1420      1430      1440
pF1KA0 LQQGQSLAVNLCGWASLSTVLLGLHSPIALDVLSEAFEESLVARDWSRALQLTEVYGRDV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LQQGQSLAVNLCGWASLSTVLLGLHSPIALDVLSEAFEESLVARDWSRALQLTEVYGRDV
             1390      1400      1410      1420      1430      1440

             1450      1460      1470      1480      1490      1500
pF1KA0 DDLSSIKDAVLSCAVACDKEGWQYLFPVKDASLRSRLALQFVDRWPLESCLEILAYCISD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 DDLSSIKDAVLSCAVACDKEGWQYLFPVKDASLRSRLALQFVDRWPLESCLEILAYCISD
             1450      1460      1470      1480      1490      1500

             1510      1520      1530      1540      1550      1560
pF1KA0 TAVQEGLKCELQRKLAELQVYQKILGLQSPPVWCDWQTLRSCCVEDPSTVMNMILEAQEY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 TAVQEGLKCELQRKLAELQVYQKILGLQSPPVWCDWQTLRSCCVEDPSTVMNMILEAQEY
             1510      1520      1530      1540      1550      1560

             1570      1580      1590      1600      1610      1620
pF1KA0 ELCEEWGCLYPIPREHLISLHQKHLLHLLERRDHDKALQLLRRIPDPTMCLEVTEQSLDQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 ELCEEWGCLYPIPREHLISLHQKHLLHLLERRDHDKALQLLRRIPDPTMCLEVTEQSLDQ
             1570      1580      1590      1600      1610      1620

             1630      1640      1650      1660      1670      1680
pF1KA0 HTSLATSHFLANYLTTHFYGQLTAVRHREIQALYVGSKILLTLPEQHRASYSHLSSNPLF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 HTSLATSHFLANYLTTHFYGQLTAVRHREIQALYVGSKILLTLPEQHRASYSHLSSNPLF
             1630      1640      1650      1660      1670      1680

             1690      1700      1710      1720      1730      1740
pF1KA0 MLEQLLMNMKVDWATVAVQTLQQLLVGQEIGFTMDEVDSLLSRYAEKALDFPYPQREKRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 MLEQLLMNMKVDWATVAVQTLQQLLVGQEIGFTMDEVDSLLSRYAEKALDFPYPQREKRS
             1690      1700      1710      1720      1730      1740

             1750      1760      1770      1780      1790      1800
pF1KA0 DSVIHLQEIVHQAADPETLPRSPSAEFSPAAPPGISSIHSPSLRERSFPPTQPSQEFVPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 DSVIHLQEIVHQAADPETLPRSPSAEFSPAAPPGISSIHSPSLRERSFPPTQPSQEFVPP
             1750      1760      1770      1780      1790      1800

             1810      1820      1830      1840      1850      1860
pF1KA0 ATPPARHQWVPDETESICMVCCREHFTMFNRRHHCRRCGRLVCSSCSTKKMVVEGCRENP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 ATPPARHQWVPDETESICMVCCREHFTMFNRRHHCRRCGRLVCSSCSTKKMVVEGCRENP
             1810      1820      1830      1840      1850      1860

             1870      1880      1890      1900      1910      1920
pF1KA0 ARVCDQCYSYCNKDVPEEPSEKPEALDSSKSESPPYSFVVRVPKADEVEWILDLKEEENE
       ::::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::
NP_056 ARVCDQCYSYCNKDVPEEPSEKPEALDSSKNESPPYSFVVRVPKADEVEWILDLKEEENE
             1870      1880      1890      1900      1910      1920

             1930      1940      1950      1960      1970      1980
pF1KA0 LVRSEFYYEQAPSASLCIAILNLHRDSIACGHQLIEHCCRLSKGLTNPEVDAGLLTDIMK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LVRSEFYYEQAPSASLCIAILNLHRDSIACGHQLIEHCCRLSKGLTNPEVDAGLLTDIMK
             1930      1940      1950      1960      1970      1980

             1990      2000      2010      2020      2030      2040
pF1KA0 QLLFSAKMMFVKAGQSQDLALCDSYISKVDVLNILVAAAYRHVPSLDQILQPAAVTRLRN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 QLLFSAKMMFVKAGQSQDLALCDSYISKVDVLNILVAAAYRHVPSLDQILQPAAVTRLRN
             1990      2000      2010      2020      2030      2040

             2050      2060      2070      2080      2090      2100
pF1KA0 QLLEAEYYQLGVEVSTKTGLDTTGAWHAWGMACLKAGNLTAAREKFSRCLKPPFDLNQLN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 QLLEAEYYQLGVEVSTKTGLDTTGAWHAWGMACLKAGNLTAAREKFSRCLKPPFDLNQLN
             2050      2060      2070      2080      2090      2100

             2110      2120      2130      2140      2150      2160
pF1KA0 HGSRLVQDVVEYLESTVRPFVSLQDDDYFATLRELEATLRTQSLSLAVIPEGKIMNNTYY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 HGSRLVQDVVEYLESTVRPFVSLQDDDYFATLRELEATLRTQSLSLAVIPEGKIMNNTYY
             2110      2120      2130      2140      2150      2160

             2170      2180      2190      2200      2210      2220
pF1KA0 QECLFYLHNYSTNLAIISFYVRHSCLREALLHLLNKESPPEVFIEGIFQPSYKSGKLHTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 QECLFYLHNYSTNLAIISFYVRHSCLREALLHLLNKESPPEVFIEGIFQPSYKSGKLHTL
             2170      2180      2190      2200      2210      2220

             2230      2240      2250      2260      2270      2280
pF1KA0 ENLLESIDPTLESWGKYLIAACQHLQKKNYYHILYELQQFMKDQVRAAMTCIRFFSHKAK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 ENLLESIDPTLESWGKYLIAACQHLQKKNYYHILYELQQFMKDQVRAAMTCIRFFSHKAK
             2230      2240      2250      2260      2270      2280

             2290      2300      2310      2320      2330      2340
pF1KA0 SYTELGEKLSWLLKAKDHLKIYLQETSRSSGRKKTTFFRKKMTAADVSRHMNTLQLQMEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 SYTELGEKLSWLLKAKDHLKIYLQETSRSSGRKKTTFFRKKMTAADVSRHMNTLQLQMEV
             2290      2300      2310      2320      2330      2340

             2350      2360      2370      2380      2390      2400
pF1KA0 TRFLHRCESAGTSQITTLPLPTLFGNNHMKMDVACKVMLGGKNVEDGFGIAFRVLQDFQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 TRFLHRCESAGTSQITTLPLPTLFGNNHMKMDVACKVMLGGKNVEDGFGIAFRVLQDFQL
             2350      2360      2370      2380      2390      2400

             2410      2420      2430      2440      2450      2460
pF1KA0 DAAMTYCRAARQLVEKEKYSEIQQLLKCVSESGMAAKSDGDTILLNCLEAFKRIPPQELE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 DAAMTYCRAARQLVEKEKYSEIQQLLKCVSESGMAAKSDGDTILLNCLEAFKRIPPQELE
             2410      2420      2430      2440      2450      2460

             2470      2480      2490      2500      2510      2520
pF1KA0 GLIQAIHNDDNKVRAYLICCKLRSAYLIAVKQEHSRATALVQQVQQAAKSSGDAVVQDIC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 GLIQAIHNDDNKVRAYLICCKLRSAYLIAVKQEHSRATALVQQVQQAAKSSGDAVVQDIC
             2470      2480      2490      2500      2510      2520

             2530         
pF1KA0 AQWLLTSHPRGAHGPGSRK
       :::::::::::::::::::
NP_056 AQWLLTSHPRGAHGPGSRK
             2530         

>>XP_016876613 (OMIM: 270700,612012) PREDICTED: zinc fin  (2545 aa)
 initn: 11664 init1: 11664 opt: 17005  Z-score: 13988.8  bits: 2602.6 E(85289):    0
Smith-Waterman score: 17005; 99.6% identity (99.7% similar) in 2545 aa overlap (1-2539:1-2545)

               10        20        30        40        50        60
pF1KA0 MNHPFGKEEAASQKQLFGFFCECLRRGEWELAQACVPQLQEGQGDIPKRVEDILQALVVC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNHPFGKEEAASQKQLFGFFCECLRRGEWELAQACVPQLQEGQGDIPKRVEDILQALVVC
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 PNLLRCGQDINPQRVAWVWLLVLEKWLAREKKLLPVVFRRKLEFLLLSEDLQGDIPENIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PNLLRCGQDINPQRVAWVWLLVLEKWLAREKKLLPVVFRRKLEFLLLSEDLQGDIPENIL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 EELYETLTQGAVGHVPDGNPRRESWTPRLSSEAVSVLWDLLRQSPQPAQALLELLLEEDD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EELYETLTQGAVGHVPDGNPRRESWTPRLSSEAVSVLWDLLRQSPQPAQALLELLLEEDD
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 GTGLCHWPLQNALVDLIRKALRALQGPDSVPPGVVDAIYGALRTLRCPAEPLGVELHLLC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTGLCHWPLQNALVDLIRKALRALQGPDSVPPGVVDAIYGALRTLRCPAEPLGVELHLLC
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA0 EELLEACRTEGSPLREERLLSCLLHKASRGLLSLYGHTYAEKVTEKPPRATASGKVSPDH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EELLEACRTEGSPLREERLLSCLLHKASRGLLSLYGHTYAEKVTEKPPRATASGKVSPDH
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA0 LDPERAMLALFSNPNPAEAWKVAYFYCLSNNKHFLEQILVTALTLLKEEDFPNLGCLLDR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDPERAMLALFSNPNPAEAWKVAYFYCLSNNKHFLEQILVTALTLLKEEDFPNLGCLLDR
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA0 EFRPLSCLLVLLGWTHCQSLESAKRLLQTLHRTQGPGCDELLRDACDGLWAHLEVLEWCI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EFRPLSCLLVLLGWTHCQSLESAKRLLQTLHRTQGPGCDELLRDACDGLWAHLEVLEWCI
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KA0 QQSSNPIPKRDLLYHLHGGDSHSVLYTLHHLTNLPALREEDVLKLLQKVPAKDPQQEPDA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQSSNPIPKRDLLYHLHGGDSHSVLYTLHHLTNLPALREEDVLKLLQKVPAKDPQQEPDA
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KA0 VDAPVPEHLSQCQNLTLYQGFCAMKYAIYALCVNSHQHSQCQDCKDSLSEDLASATEPAN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VDAPVPEHLSQCQNLTLYQGFCAMKYAIYALCVNSHQHSQCQDCKDSLSEDLASATEPAN
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KA0 DSLSSPGAANLFSTYPARCQQYLCSIPDSLCLELLENIFSLLLITSADLHPEPHLPEDYA
       ::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSLSSPGAANLFSTYLARCQQYLCSIPDSLCLELLENIFSLLLITSADLHPEPHLPEDYA
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KA0 EDDDIEGKSPSGLRSPSESPQHIAHPERKSERGSLGVPKTLAYTMPSHVKAEPKDSYPGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDDDIEGKSPSGLRSPSESPQHIAHPERKSERGSLGVPKTLAYTMPSHVKAEPKDSYPGP
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KA0 HRHSFLDLKHFTSGISGFLADEFAIGAFLRLLQEQLDEISSRSPPEKPKQESQSCSGSRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HRHSFLDLKHFTSGISGFLADEFAIGAFLRLLQEQLDEISSRSPPEKPKQESQSCSGSRD
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KA0 GLQSRLHRLSKVVSEAQWRHKVVTSNHRSEEQPSRRYQPATRHPSLRRGRRTRRSQADGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLQSRLHRLSKVVSEAQWRHKVVTSNHRSEEQPSRRYQPATRHPSLRRGRRTRRSQADGR
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KA0 DRGSNPSLESTSSELSTSTSEGSLSAMSGRNELHSRLHPHPQSSLIPMMFSPPESLLASC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DRGSNPSLESTSSELSTSTSEGSLSAMSGRNELHSRLHPHPQSSLIPMMFSPPESLLASC
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KA0 ILRGNFAEAHQVLFTFNLKSSPSSGELMFMERYQEVIQELAQVEHKIENQNSDAGSSTIR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILRGNFAEAHQVLFTFNLKSSPSSGELMFMERYQEVIQELAQVEHKIENQNSDAGSSTIR
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KA0 RTGSGRSTLQAIGSAAAAGMVFYSISDVTDKLLNTSGDPIPMLQEDFWISTALVEPTAPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RTGSGRSTLQAIGSAAAAGMVFYSISDVTDKLLNTSGDPIPMLQEDFWISTALVEPTAPL
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KA0 REVLEDLSPPAMAAFDLACSQCQLWKTCKQLLETAERRLNSSLERRGRRIDHVLLNADGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 REVLEDLSPPAMAAFDLACSQCQLWKTCKQLLETAERRLNSSLERRGRRIDHVLLNADGI
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KA0 RGFPVVLQQISKSLNYLLMTASQTKSESVEEKGGGPPRCSITELLQMCWPSLSEDCVASH
       :::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::
XP_016 RGFPVVLQQISKSLNYLLMSASQTKSESVEEKGGGPPRCSITELLQMCWPSLSEDCVASH
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KA0 TTLSQQLDQVLQSLREALELPEPRTPPLSSLVEQAAQKAPEAEAHPVQIQTQLLQKNLGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TTLSQQLDQVLQSLREALELPEPRTPPLSSLVEQAAQKAPEAEAHPVQIQTQLLQKNLGK
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KA0 QTPSGSRQMDYLGTFFSYCSTLAAVLLQSLSSEPDHVEVKVGNPFVLLQQSSSQLVSHLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QTPSGSRQMDYLGTFFSYCSTLAAVLLQSLSSEPDHVEVKVGNPFVLLQQSSSQLVSHLL
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KA0 FERQVPPERLAALLAQENLSLSVPQVIVSCCCEPLALCSSRQSQQTSSLLTRLGTLAQLH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FERQVPPERLAALLAQENLSLSVPQVIVSCCCEPLALCSSRQSQQTSSLLTRLGTLAQLH
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KA0 ASHCLDDLPLSTPSSPRTTENPTLERKPYSSPRDSSLPALTSSALAFLKSRSKLLATVAC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASHCLDDLPLSTPSSPRTTENPTLERKPYSSPRDSSLPALTSSALAFLKSRSKLLATVAC
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KA0 LGASPRLKVSKPSLSWKELRGRREVPLAAEQVARECERLLEQFPLFEAFLLAAWEPLRGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGASPRLKVSKPSLSWKELRGRREVPLAAEQVARECERLLEQFPLFEAFLLAAWEPLRGS
             1330      1340      1350      1360      1370      1380

             1390      1400      1410      1420      1430      1440
pF1KA0 LQQGQSLAVNLCGWASLSTVLLGLHSPIALDVLSEAFEESLVARDWSRALQLTEVYGRDV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQQGQSLAVNLCGWASLSTVLLGLHSPIALDVLSEAFEESLVARDWSRALQLTEVYGRDV
             1390      1400      1410      1420      1430      1440

             1450      1460      1470      1480      1490      1500
pF1KA0 DDLSSIKDAVLSCAVACDKEGWQYLFPVKDASLRSRLALQFVDRWPLESCLEILAYCISD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DDLSSIKDAVLSCAVACDKEGWQYLFPVKDASLRSRLALQFVDRWPLESCLEILAYCISD
             1450      1460      1470      1480      1490      1500

             1510      1520      1530      1540      1550      1560
pF1KA0 TAVQEGLKCELQRKLAELQVYQKILGLQSPPVWCDWQTLRSCCVEDPSTVMNMILEAQEY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TAVQEGLKCELQRKLAELQVYQKILGLQSPPVWCDWQTLRSCCVEDPSTVMNMILEAQEY
             1510      1520      1530      1540      1550      1560

             1570      1580      1590      1600      1610      1620
pF1KA0 ELCEEWGCLYPIPREHLISLHQKHLLHLLERRDHDKALQLLRRIPDPTMCLEVTEQSLDQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELCEEWGCLYPIPREHLISLHQKHLLHLLERRDHDKALQLLRRIPDPTMCLEVTEQSLDQ
             1570      1580      1590      1600      1610      1620

             1630      1640      1650      1660      1670      1680
pF1KA0 HTSLATSHFLANYLTTHFYGQLTAVRHREIQALYVGSKILLTLPEQHRASYSHLSSNPLF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HTSLATSHFLANYLTTHFYGQLTAVRHREIQALYVGSKILLTLPEQHRASYSHLSSNPLF
             1630      1640      1650      1660      1670      1680

             1690      1700      1710      1720      1730      1740
pF1KA0 MLEQLLMNMKVDWATVAVQTLQQLLVGQEIGFTMDEVDSLLSRYAEKALDFPYPQREKRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MLEQLLMNMKVDWATVAVQTLQQLLVGQEIGFTMDEVDSLLSRYAEKALDFPYPQREKRS
             1690      1700      1710      1720      1730      1740

                   1750      1760      1770      1780      1790    
pF1KA0 ------DSVIHLQEIVHQAADPETLPRSPSAEFSPAAPPGISSIHSPSLRERSFPPTQPS
             ::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AFSLSTDSVIHLQEIVHQAADPETLPRSPSAEFSPAAPPGISSIHSPSLRERSFPPTQPS
             1750      1760      1770      1780      1790      1800

         1800      1810      1820      1830      1840      1850    
pF1KA0 QEFVPPATPPARHQWVPDETESICMVCCREHFTMFNRRHHCRRCGRLVCSSCSTKKMVVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QEFVPPATPPARHQWVPDETESICMVCCREHFTMFNRRHHCRRCGRLVCSSCSTKKMVVE
             1810      1820      1830      1840      1850      1860

         1860      1870      1880      1890      1900      1910    
pF1KA0 GCRENPARVCDQCYSYCNKDVPEEPSEKPEALDSSKSESPPYSFVVRVPKADEVEWILDL
       ::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::::
XP_016 GCRENPARVCDQCYSYCNKDVPEEPSEKPEALDSSKNESPPYSFVVRVPKADEVEWILDL
             1870      1880      1890      1900      1910      1920

         1920      1930      1940      1950      1960      1970    
pF1KA0 KEEENELVRSEFYYEQAPSASLCIAILNLHRDSIACGHQLIEHCCRLSKGLTNPEVDAGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEEENELVRSEFYYEQAPSASLCIAILNLHRDSIACGHQLIEHCCRLSKGLTNPEVDAGL
             1930      1940      1950      1960      1970      1980

         1980      1990      2000      2010      2020      2030    
pF1KA0 LTDIMKQLLFSAKMMFVKAGQSQDLALCDSYISKVDVLNILVAAAYRHVPSLDQILQPAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTDIMKQLLFSAKMMFVKAGQSQDLALCDSYISKVDVLNILVAAAYRHVPSLDQILQPAA
             1990      2000      2010      2020      2030      2040

         2040      2050      2060      2070      2080      2090    
pF1KA0 VTRLRNQLLEAEYYQLGVEVSTKTGLDTTGAWHAWGMACLKAGNLTAAREKFSRCLKPPF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTRLRNQLLEAEYYQLGVEVSTKTGLDTTGAWHAWGMACLKAGNLTAAREKFSRCLKPPF
             2050      2060      2070      2080      2090      2100

         2100      2110      2120      2130      2140      2150    
pF1KA0 DLNQLNHGSRLVQDVVEYLESTVRPFVSLQDDDYFATLRELEATLRTQSLSLAVIPEGKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLNQLNHGSRLVQDVVEYLESTVRPFVSLQDDDYFATLRELEATLRTQSLSLAVIPEGKI
             2110      2120      2130      2140      2150      2160

         2160      2170      2180      2190      2200      2210    
pF1KA0 MNNTYYQECLFYLHNYSTNLAIISFYVRHSCLREALLHLLNKESPPEVFIEGIFQPSYKS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNNTYYQECLFYLHNYSTNLAIISFYVRHSCLREALLHLLNKESPPEVFIEGIFQPSYKS
             2170      2180      2190      2200      2210      2220

         2220      2230      2240      2250      2260      2270    
pF1KA0 GKLHTLENLLESIDPTLESWGKYLIAACQHLQKKNYYHILYELQQFMKDQVRAAMTCIRF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GKLHTLENLLESIDPTLESWGKYLIAACQHLQKKNYYHILYELQQFMKDQVRAAMTCIRF
             2230      2240      2250      2260      2270      2280

         2280      2290      2300      2310      2320      2330    
pF1KA0 FSHKAKSYTELGEKLSWLLKAKDHLKIYLQETSRSSGRKKTTFFRKKMTAADVSRHMNTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FSHKAKSYTELGEKLSWLLKAKDHLKIYLQETSRSSGRKKTTFFRKKMTAADVSRHMNTL
             2290      2300      2310      2320      2330      2340

         2340      2350      2360      2370      2380      2390    
pF1KA0 QLQMEVTRFLHRCESAGTSQITTLPLPTLFGNNHMKMDVACKVMLGGKNVEDGFGIAFRV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLQMEVTRFLHRCESAGTSQITTLPLPTLFGNNHMKMDVACKVMLGGKNVEDGFGIAFRV
             2350      2360      2370      2380      2390      2400

         2400      2410      2420      2430      2440      2450    
pF1KA0 LQDFQLDAAMTYCRAARQLVEKEKYSEIQQLLKCVSESGMAAKSDGDTILLNCLEAFKRI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQDFQLDAAMTYCRAARQLVEKEKYSEIQQLLKCVSESGMAAKSDGDTILLNCLEAFKRI
             2410      2420      2430      2440      2450      2460

         2460      2470      2480      2490      2500      2510    
pF1KA0 PPQELEGLIQAIHNDDNKVRAYLICCKLRSAYLIAVKQEHSRATALVQQVQQAAKSSGDA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPQELEGLIQAIHNDDNKVRAYLICCKLRSAYLIAVKQEHSRATALVQQVQQAAKSSGDA
             2470      2480      2490      2500      2510      2520

         2520      2530         
pF1KA0 VVQDICAQWLLTSHPRGAHGPGSRK
       :::::::::::::::::::::::::
XP_016 VVQDICAQWLLTSHPRGAHGPGSRK
             2530      2540     

>>XP_016876614 (OMIM: 270700,612012) PREDICTED: zinc fin  (2503 aa)
 initn: 16580 init1: 11664 opt: 16564  Z-score: 13626.0  bits: 2535.4 E(85289):    0
Smith-Waterman score: 16564; 99.3% identity (99.4% similar) in 2489 aa overlap (1-2483:1-2489)

               10        20        30        40        50        60
pF1KA0 MNHPFGKEEAASQKQLFGFFCECLRRGEWELAQACVPQLQEGQGDIPKRVEDILQALVVC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNHPFGKEEAASQKQLFGFFCECLRRGEWELAQACVPQLQEGQGDIPKRVEDILQALVVC
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 PNLLRCGQDINPQRVAWVWLLVLEKWLAREKKLLPVVFRRKLEFLLLSEDLQGDIPENIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PNLLRCGQDINPQRVAWVWLLVLEKWLAREKKLLPVVFRRKLEFLLLSEDLQGDIPENIL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 EELYETLTQGAVGHVPDGNPRRESWTPRLSSEAVSVLWDLLRQSPQPAQALLELLLEEDD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EELYETLTQGAVGHVPDGNPRRESWTPRLSSEAVSVLWDLLRQSPQPAQALLELLLEEDD
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 GTGLCHWPLQNALVDLIRKALRALQGPDSVPPGVVDAIYGALRTLRCPAEPLGVELHLLC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTGLCHWPLQNALVDLIRKALRALQGPDSVPPGVVDAIYGALRTLRCPAEPLGVELHLLC
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA0 EELLEACRTEGSPLREERLLSCLLHKASRGLLSLYGHTYAEKVTEKPPRATASGKVSPDH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EELLEACRTEGSPLREERLLSCLLHKASRGLLSLYGHTYAEKVTEKPPRATASGKVSPDH
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA0 LDPERAMLALFSNPNPAEAWKVAYFYCLSNNKHFLEQILVTALTLLKEEDFPNLGCLLDR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDPERAMLALFSNPNPAEAWKVAYFYCLSNNKHFLEQILVTALTLLKEEDFPNLGCLLDR
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA0 EFRPLSCLLVLLGWTHCQSLESAKRLLQTLHRTQGPGCDELLRDACDGLWAHLEVLEWCI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EFRPLSCLLVLLGWTHCQSLESAKRLLQTLHRTQGPGCDELLRDACDGLWAHLEVLEWCI
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KA0 QQSSNPIPKRDLLYHLHGGDSHSVLYTLHHLTNLPALREEDVLKLLQKVPAKDPQQEPDA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQSSNPIPKRDLLYHLHGGDSHSVLYTLHHLTNLPALREEDVLKLLQKVPAKDPQQEPDA
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KA0 VDAPVPEHLSQCQNLTLYQGFCAMKYAIYALCVNSHQHSQCQDCKDSLSEDLASATEPAN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VDAPVPEHLSQCQNLTLYQGFCAMKYAIYALCVNSHQHSQCQDCKDSLSEDLASATEPAN
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KA0 DSLSSPGAANLFSTYPARCQQYLCSIPDSLCLELLENIFSLLLITSADLHPEPHLPEDYA
       ::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSLSSPGAANLFSTYLARCQQYLCSIPDSLCLELLENIFSLLLITSADLHPEPHLPEDYA
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KA0 EDDDIEGKSPSGLRSPSESPQHIAHPERKSERGSLGVPKTLAYTMPSHVKAEPKDSYPGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDDDIEGKSPSGLRSPSESPQHIAHPERKSERGSLGVPKTLAYTMPSHVKAEPKDSYPGP
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KA0 HRHSFLDLKHFTSGISGFLADEFAIGAFLRLLQEQLDEISSRSPPEKPKQESQSCSGSRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HRHSFLDLKHFTSGISGFLADEFAIGAFLRLLQEQLDEISSRSPPEKPKQESQSCSGSRD
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KA0 GLQSRLHRLSKVVSEAQWRHKVVTSNHRSEEQPSRRYQPATRHPSLRRGRRTRRSQADGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLQSRLHRLSKVVSEAQWRHKVVTSNHRSEEQPSRRYQPATRHPSLRRGRRTRRSQADGR
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KA0 DRGSNPSLESTSSELSTSTSEGSLSAMSGRNELHSRLHPHPQSSLIPMMFSPPESLLASC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DRGSNPSLESTSSELSTSTSEGSLSAMSGRNELHSRLHPHPQSSLIPMMFSPPESLLASC
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KA0 ILRGNFAEAHQVLFTFNLKSSPSSGELMFMERYQEVIQELAQVEHKIENQNSDAGSSTIR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILRGNFAEAHQVLFTFNLKSSPSSGELMFMERYQEVIQELAQVEHKIENQNSDAGSSTIR
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KA0 RTGSGRSTLQAIGSAAAAGMVFYSISDVTDKLLNTSGDPIPMLQEDFWISTALVEPTAPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RTGSGRSTLQAIGSAAAAGMVFYSISDVTDKLLNTSGDPIPMLQEDFWISTALVEPTAPL
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KA0 REVLEDLSPPAMAAFDLACSQCQLWKTCKQLLETAERRLNSSLERRGRRIDHVLLNADGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 REVLEDLSPPAMAAFDLACSQCQLWKTCKQLLETAERRLNSSLERRGRRIDHVLLNADGI
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KA0 RGFPVVLQQISKSLNYLLMTASQTKSESVEEKGGGPPRCSITELLQMCWPSLSEDCVASH
       :::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::
XP_016 RGFPVVLQQISKSLNYLLMSASQTKSESVEEKGGGPPRCSITELLQMCWPSLSEDCVASH
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KA0 TTLSQQLDQVLQSLREALELPEPRTPPLSSLVEQAAQKAPEAEAHPVQIQTQLLQKNLGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TTLSQQLDQVLQSLREALELPEPRTPPLSSLVEQAAQKAPEAEAHPVQIQTQLLQKNLGK
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KA0 QTPSGSRQMDYLGTFFSYCSTLAAVLLQSLSSEPDHVEVKVGNPFVLLQQSSSQLVSHLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QTPSGSRQMDYLGTFFSYCSTLAAVLLQSLSSEPDHVEVKVGNPFVLLQQSSSQLVSHLL
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KA0 FERQVPPERLAALLAQENLSLSVPQVIVSCCCEPLALCSSRQSQQTSSLLTRLGTLAQLH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FERQVPPERLAALLAQENLSLSVPQVIVSCCCEPLALCSSRQSQQTSSLLTRLGTLAQLH
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KA0 ASHCLDDLPLSTPSSPRTTENPTLERKPYSSPRDSSLPALTSSALAFLKSRSKLLATVAC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASHCLDDLPLSTPSSPRTTENPTLERKPYSSPRDSSLPALTSSALAFLKSRSKLLATVAC
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KA0 LGASPRLKVSKPSLSWKELRGRREVPLAAEQVARECERLLEQFPLFEAFLLAAWEPLRGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGASPRLKVSKPSLSWKELRGRREVPLAAEQVARECERLLEQFPLFEAFLLAAWEPLRGS
             1330      1340      1350      1360      1370      1380

             1390      1400      1410      1420      1430      1440
pF1KA0 LQQGQSLAVNLCGWASLSTVLLGLHSPIALDVLSEAFEESLVARDWSRALQLTEVYGRDV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQQGQSLAVNLCGWASLSTVLLGLHSPIALDVLSEAFEESLVARDWSRALQLTEVYGRDV
             1390      1400      1410      1420      1430      1440

             1450      1460      1470      1480      1490      1500
pF1KA0 DDLSSIKDAVLSCAVACDKEGWQYLFPVKDASLRSRLALQFVDRWPLESCLEILAYCISD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DDLSSIKDAVLSCAVACDKEGWQYLFPVKDASLRSRLALQFVDRWPLESCLEILAYCISD
             1450      1460      1470      1480      1490      1500

             1510      1520      1530      1540      1550      1560
pF1KA0 TAVQEGLKCELQRKLAELQVYQKILGLQSPPVWCDWQTLRSCCVEDPSTVMNMILEAQEY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TAVQEGLKCELQRKLAELQVYQKILGLQSPPVWCDWQTLRSCCVEDPSTVMNMILEAQEY
             1510      1520      1530      1540      1550      1560

             1570      1580      1590      1600      1610      1620
pF1KA0 ELCEEWGCLYPIPREHLISLHQKHLLHLLERRDHDKALQLLRRIPDPTMCLEVTEQSLDQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELCEEWGCLYPIPREHLISLHQKHLLHLLERRDHDKALQLLRRIPDPTMCLEVTEQSLDQ
             1570      1580      1590      1600      1610      1620

             1630      1640      1650      1660      1670      1680
pF1KA0 HTSLATSHFLANYLTTHFYGQLTAVRHREIQALYVGSKILLTLPEQHRASYSHLSSNPLF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HTSLATSHFLANYLTTHFYGQLTAVRHREIQALYVGSKILLTLPEQHRASYSHLSSNPLF
             1630      1640      1650      1660      1670      1680

             1690      1700      1710      1720      1730      1740
pF1KA0 MLEQLLMNMKVDWATVAVQTLQQLLVGQEIGFTMDEVDSLLSRYAEKALDFPYPQREKRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MLEQLLMNMKVDWATVAVQTLQQLLVGQEIGFTMDEVDSLLSRYAEKALDFPYPQREKRS
             1690      1700      1710      1720      1730      1740

                   1750      1760      1770      1780      1790    
pF1KA0 ------DSVIHLQEIVHQAADPETLPRSPSAEFSPAAPPGISSIHSPSLRERSFPPTQPS
             ::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AFSLSTDSVIHLQEIVHQAADPETLPRSPSAEFSPAAPPGISSIHSPSLRERSFPPTQPS
             1750      1760      1770      1780      1790      1800

         1800      1810      1820      1830      1840      1850    
pF1KA0 QEFVPPATPPARHQWVPDETESICMVCCREHFTMFNRRHHCRRCGRLVCSSCSTKKMVVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QEFVPPATPPARHQWVPDETESICMVCCREHFTMFNRRHHCRRCGRLVCSSCSTKKMVVE
             1810      1820      1830      1840      1850      1860

         1860      1870      1880      1890      1900      1910    
pF1KA0 GCRENPARVCDQCYSYCNKDVPEEPSEKPEALDSSKSESPPYSFVVRVPKADEVEWILDL
       ::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::::
XP_016 GCRENPARVCDQCYSYCNKDVPEEPSEKPEALDSSKNESPPYSFVVRVPKADEVEWILDL
             1870      1880      1890      1900      1910      1920

         1920      1930      1940      1950      1960      1970    
pF1KA0 KEEENELVRSEFYYEQAPSASLCIAILNLHRDSIACGHQLIEHCCRLSKGLTNPEVDAGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEEENELVRSEFYYEQAPSASLCIAILNLHRDSIACGHQLIEHCCRLSKGLTNPEVDAGL
             1930      1940      1950      1960      1970      1980

         1980      1990      2000      2010      2020      2030    
pF1KA0 LTDIMKQLLFSAKMMFVKAGQSQDLALCDSYISKVDVLNILVAAAYRHVPSLDQILQPAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTDIMKQLLFSAKMMFVKAGQSQDLALCDSYISKVDVLNILVAAAYRHVPSLDQILQPAA
             1990      2000      2010      2020      2030      2040

         2040      2050      2060      2070      2080      2090    
pF1KA0 VTRLRNQLLEAEYYQLGVEVSTKTGLDTTGAWHAWGMACLKAGNLTAAREKFSRCLKPPF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTRLRNQLLEAEYYQLGVEVSTKTGLDTTGAWHAWGMACLKAGNLTAAREKFSRCLKPPF
             2050      2060      2070      2080      2090      2100

         2100      2110      2120      2130      2140      2150    
pF1KA0 DLNQLNHGSRLVQDVVEYLESTVRPFVSLQDDDYFATLRELEATLRTQSLSLAVIPEGKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLNQLNHGSRLVQDVVEYLESTVRPFVSLQDDDYFATLRELEATLRTQSLSLAVIPEGKI
             2110      2120      2130      2140      2150      2160

         2160      2170      2180      2190      2200      2210    
pF1KA0 MNNTYYQECLFYLHNYSTNLAIISFYVRHSCLREALLHLLNKESPPEVFIEGIFQPSYKS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNNTYYQECLFYLHNYSTNLAIISFYVRHSCLREALLHLLNKESPPEVFIEGIFQPSYKS
             2170      2180      2190      2200      2210      2220

         2220      2230      2240      2250      2260      2270    
pF1KA0 GKLHTLENLLESIDPTLESWGKYLIAACQHLQKKNYYHILYELQQFMKDQVRAAMTCIRF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GKLHTLENLLESIDPTLESWGKYLIAACQHLQKKNYYHILYELQQFMKDQVRAAMTCIRF
             2230      2240      2250      2260      2270      2280

         2280      2290      2300      2310      2320      2330    
pF1KA0 FSHKAKSYTELGEKLSWLLKAKDHLKIYLQETSRSSGRKKTTFFRKKMTAADVSRHMNTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FSHKAKSYTELGEKLSWLLKAKDHLKIYLQETSRSSGRKKTTFFRKKMTAADVSRHMNTL
             2290      2300      2310      2320      2330      2340

         2340      2350      2360      2370      2380      2390    
pF1KA0 QLQMEVTRFLHRCESAGTSQITTLPLPTLFGNNHMKMDVACKVMLGGKNVEDGFGIAFRV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLQMEVTRFLHRCESAGTSQITTLPLPTLFGNNHMKMDVACKVMLGGKNVEDGFGIAFRV
             2350      2360      2370      2380      2390      2400

         2400      2410      2420      2430      2440      2450    
pF1KA0 LQDFQLDAAMTYCRAARQLVEKEKYSEIQQLLKCVSESGMAAKSDGDTILLNCLEAFKRI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQDFQLDAAMTYCRAARQLVEKEKYSEIQQLLKCVSESGMAAKSDGDTILLNCLEAFKRI
             2410      2420      2430      2440      2450      2460

         2460      2470      2480      2490      2500      2510    
pF1KA0 PPQELEGLIQAIHNDDNKVRAYLICCKLRSAYLIAVKQEHSRATALVQQVQQAAKSSGDA
       ::::::::::::::::::.   :   . :                               
XP_016 PPQELEGLIQAIHNDDNKIVPILAALRDRVHTEERGRSPSTLC                 
             2470      2480      2490      2500                    

>>XP_016876615 (OMIM: 270700,612012) PREDICTED: zinc fin  (2042 aa)
 initn: 8190 init1: 8190 opt: 13531  Z-score: 11131.7  bits: 2073.6 E(85289):    0
Smith-Waterman score: 13531; 99.6% identity (99.7% similar) in 2042 aa overlap (504-2539:1-2042)

           480       490       500       510       520       530   
pF1KA0 PQQEPDAVDAPVPEHLSQCQNLTLYQGFCAMKYAIYALCVNSHQHSQCQDCKDSLSEDLA
                                     ::::::::::::::::::::::::::::::
XP_016                               MKYAIYALCVNSHQHSQCQDCKDSLSEDLA
                                             10        20        30

           540       550       560       570       580       590   
pF1KA0 SATEPANDSLSSPGAANLFSTYPARCQQYLCSIPDSLCLELLENIFSLLLITSADLHPEP
       :::::::::::::::::::::: :::::::::::::::::::::::::::::::::::::
XP_016 SATEPANDSLSSPGAANLFSTYLARCQQYLCSIPDSLCLELLENIFSLLLITSADLHPEP
               40        50        60        70        80        90

           600       610       620       630       640       650   
pF1KA0 HLPEDYAEDDDIEGKSPSGLRSPSESPQHIAHPERKSERGSLGVPKTLAYTMPSHVKAEP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HLPEDYAEDDDIEGKSPSGLRSPSESPQHIAHPERKSERGSLGVPKTLAYTMPSHVKAEP
              100       110       120       130       140       150

           660       670       680       690       700       710   
pF1KA0 KDSYPGPHRHSFLDLKHFTSGISGFLADEFAIGAFLRLLQEQLDEISSRSPPEKPKQESQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KDSYPGPHRHSFLDLKHFTSGISGFLADEFAIGAFLRLLQEQLDEISSRSPPEKPKQESQ
              160       170       180       190       200       210

           720       730       740       750       760       770   
pF1KA0 SCSGSRDGLQSRLHRLSKVVSEAQWRHKVVTSNHRSEEQPSRRYQPATRHPSLRRGRRTR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SCSGSRDGLQSRLHRLSKVVSEAQWRHKVVTSNHRSEEQPSRRYQPATRHPSLRRGRRTR
              220       230       240       250       260       270

           780       790       800       810       820       830   
pF1KA0 RSQADGRDRGSNPSLESTSSELSTSTSEGSLSAMSGRNELHSRLHPHPQSSLIPMMFSPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSQADGRDRGSNPSLESTSSELSTSTSEGSLSAMSGRNELHSRLHPHPQSSLIPMMFSPP
              280       290       300       310       320       330

           840       850       860       870       880       890   
pF1KA0 ESLLASCILRGNFAEAHQVLFTFNLKSSPSSGELMFMERYQEVIQELAQVEHKIENQNSD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESLLASCILRGNFAEAHQVLFTFNLKSSPSSGELMFMERYQEVIQELAQVEHKIENQNSD
              340       350       360       370       380       390

           900       910       920       930       940       950   
pF1KA0 AGSSTIRRTGSGRSTLQAIGSAAAAGMVFYSISDVTDKLLNTSGDPIPMLQEDFWISTAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGSSTIRRTGSGRSTLQAIGSAAAAGMVFYSISDVTDKLLNTSGDPIPMLQEDFWISTAL
              400       410       420       430       440       450

           960       970       980       990      1000      1010   
pF1KA0 VEPTAPLREVLEDLSPPAMAAFDLACSQCQLWKTCKQLLETAERRLNSSLERRGRRIDHV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VEPTAPLREVLEDLSPPAMAAFDLACSQCQLWKTCKQLLETAERRLNSSLERRGRRIDHV
              460       470       480       490       500       510

          1020      1030      1040      1050      1060      1070   
pF1KA0 LLNADGIRGFPVVLQQISKSLNYLLMTASQTKSESVEEKGGGPPRCSITELLQMCWPSLS
       ::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::
XP_016 LLNADGIRGFPVVLQQISKSLNYLLMSASQTKSESVEEKGGGPPRCSITELLQMCWPSLS
              520       530       540       550       560       570

          1080      1090      1100      1110      1120      1130   
pF1KA0 EDCVASHTTLSQQLDQVLQSLREALELPEPRTPPLSSLVEQAAQKAPEAEAHPVQIQTQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDCVASHTTLSQQLDQVLQSLREALELPEPRTPPLSSLVEQAAQKAPEAEAHPVQIQTQL
              580       590       600       610       620       630

          1140      1150      1160      1170      1180      1190   
pF1KA0 LQKNLGKQTPSGSRQMDYLGTFFSYCSTLAAVLLQSLSSEPDHVEVKVGNPFVLLQQSSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQKNLGKQTPSGSRQMDYLGTFFSYCSTLAAVLLQSLSSEPDHVEVKVGNPFVLLQQSSS
              640       650       660       670       680       690

          1200      1210      1220      1230      1240      1250   
pF1KA0 QLVSHLLFERQVPPERLAALLAQENLSLSVPQVIVSCCCEPLALCSSRQSQQTSSLLTRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLVSHLLFERQVPPERLAALLAQENLSLSVPQVIVSCCCEPLALCSSRQSQQTSSLLTRL
              700       710       720       730       740       750

          1260      1270      1280      1290      1300      1310   
pF1KA0 GTLAQLHASHCLDDLPLSTPSSPRTTENPTLERKPYSSPRDSSLPALTSSALAFLKSRSK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTLAQLHASHCLDDLPLSTPSSPRTTENPTLERKPYSSPRDSSLPALTSSALAFLKSRSK
              760       770       780       790       800       810

          1320      1330      1340      1350      1360      1370   
pF1KA0 LLATVACLGASPRLKVSKPSLSWKELRGRREVPLAAEQVARECERLLEQFPLFEAFLLAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLATVACLGASPRLKVSKPSLSWKELRGRREVPLAAEQVARECERLLEQFPLFEAFLLAA
              820       830       840       850       860       870

          1380      1390      1400      1410      1420      1430   
pF1KA0 WEPLRGSLQQGQSLAVNLCGWASLSTVLLGLHSPIALDVLSEAFEESLVARDWSRALQLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WEPLRGSLQQGQSLAVNLCGWASLSTVLLGLHSPIALDVLSEAFEESLVARDWSRALQLT
              880       890       900       910       920       930

          1440      1450      1460      1470      1480      1490   
pF1KA0 EVYGRDVDDLSSIKDAVLSCAVACDKEGWQYLFPVKDASLRSRLALQFVDRWPLESCLEI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EVYGRDVDDLSSIKDAVLSCAVACDKEGWQYLFPVKDASLRSRLALQFVDRWPLESCLEI
              940       950       960       970       980       990

          1500      1510      1520      1530      1540      1550   
pF1KA0 LAYCISDTAVQEGLKCELQRKLAELQVYQKILGLQSPPVWCDWQTLRSCCVEDPSTVMNM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAYCISDTAVQEGLKCELQRKLAELQVYQKILGLQSPPVWCDWQTLRSCCVEDPSTVMNM
             1000      1010      1020      1030      1040      1050

          1560      1570      1580      1590      1600      1610   
pF1KA0 ILEAQEYELCEEWGCLYPIPREHLISLHQKHLLHLLERRDHDKALQLLRRIPDPTMCLEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILEAQEYELCEEWGCLYPIPREHLISLHQKHLLHLLERRDHDKALQLLRRIPDPTMCLEV
             1060      1070      1080      1090      1100      1110

          1620      1630      1640      1650      1660      1670   
pF1KA0 TEQSLDQHTSLATSHFLANYLTTHFYGQLTAVRHREIQALYVGSKILLTLPEQHRASYSH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TEQSLDQHTSLATSHFLANYLTTHFYGQLTAVRHREIQALYVGSKILLTLPEQHRASYSH
             1120      1130      1140      1150      1160      1170

          1680      1690      1700      1710      1720      1730   
pF1KA0 LSSNPLFMLEQLLMNMKVDWATVAVQTLQQLLVGQEIGFTMDEVDSLLSRYAEKALDFPY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSSNPLFMLEQLLMNMKVDWATVAVQTLQQLLVGQEIGFTMDEVDSLLSRYAEKALDFPY
             1180      1190      1200      1210      1220      1230

          1740            1750      1760      1770      1780       
pF1KA0 PQREKRS------DSVIHLQEIVHQAADPETLPRSPSAEFSPAAPPGISSIHSPSLRERS
       :::::::      :::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PQREKRSAFSLSTDSVIHLQEIVHQAADPETLPRSPSAEFSPAAPPGISSIHSPSLRERS
             1240      1250      1260      1270      1280      1290

      1790      1800      1810      1820      1830      1840       
pF1KA0 FPPTQPSQEFVPPATPPARHQWVPDETESICMVCCREHFTMFNRRHHCRRCGRLVCSSCS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FPPTQPSQEFVPPATPPARHQWVPDETESICMVCCREHFTMFNRRHHCRRCGRLVCSSCS
             1300      1310      1320      1330      1340      1350

      1850      1860      1870      1880      1890      1900       
pF1KA0 TKKMVVEGCRENPARVCDQCYSYCNKDVPEEPSEKPEALDSSKSESPPYSFVVRVPKADE
       :::::::::::::::::::::::::::::::::::::::::::.::::::::::::::::
XP_016 TKKMVVEGCRENPARVCDQCYSYCNKDVPEEPSEKPEALDSSKNESPPYSFVVRVPKADE
             1360      1370      1380      1390      1400      1410

      1910      1920      1930      1940      1950      1960       
pF1KA0 VEWILDLKEEENELVRSEFYYEQAPSASLCIAILNLHRDSIACGHQLIEHCCRLSKGLTN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VEWILDLKEEENELVRSEFYYEQAPSASLCIAILNLHRDSIACGHQLIEHCCRLSKGLTN
             1420      1430      1440      1450      1460      1470

      1970      1980      1990      2000      2010      2020       
pF1KA0 PEVDAGLLTDIMKQLLFSAKMMFVKAGQSQDLALCDSYISKVDVLNILVAAAYRHVPSLD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PEVDAGLLTDIMKQLLFSAKMMFVKAGQSQDLALCDSYISKVDVLNILVAAAYRHVPSLD
             1480      1490      1500      1510      1520      1530

      2030      2040      2050      2060      2070      2080       
pF1KA0 QILQPAAVTRLRNQLLEAEYYQLGVEVSTKTGLDTTGAWHAWGMACLKAGNLTAAREKFS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QILQPAAVTRLRNQLLEAEYYQLGVEVSTKTGLDTTGAWHAWGMACLKAGNLTAAREKFS
             1540      1550      1560      1570      1580      1590

      2090      2100      2110      2120      2130      2140       
pF1KA0 RCLKPPFDLNQLNHGSRLVQDVVEYLESTVRPFVSLQDDDYFATLRELEATLRTQSLSLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RCLKPPFDLNQLNHGSRLVQDVVEYLESTVRPFVSLQDDDYFATLRELEATLRTQSLSLA
             1600      1610      1620      1630      1640      1650

      2150      2160      2170      2180      2190      2200       
pF1KA0 VIPEGKIMNNTYYQECLFYLHNYSTNLAIISFYVRHSCLREALLHLLNKESPPEVFIEGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VIPEGKIMNNTYYQECLFYLHNYSTNLAIISFYVRHSCLREALLHLLNKESPPEVFIEGI
             1660      1670      1680      1690      1700      1710

      2210      2220      2230      2240      2250      2260       
pF1KA0 FQPSYKSGKLHTLENLLESIDPTLESWGKYLIAACQHLQKKNYYHILYELQQFMKDQVRA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FQPSYKSGKLHTLENLLESIDPTLESWGKYLIAACQHLQKKNYYHILYELQQFMKDQVRA
             1720      1730      1740      1750      1760      1770

      2270      2280      2290      2300      2310      2320       
pF1KA0 AMTCIRFFSHKAKSYTELGEKLSWLLKAKDHLKIYLQETSRSSGRKKTTFFRKKMTAADV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AMTCIRFFSHKAKSYTELGEKLSWLLKAKDHLKIYLQETSRSSGRKKTTFFRKKMTAADV
             1780      1790      1800      1810      1820      1830

      2330      2340      2350      2360      2370      2380       
pF1KA0 SRHMNTLQLQMEVTRFLHRCESAGTSQITTLPLPTLFGNNHMKMDVACKVMLGGKNVEDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SRHMNTLQLQMEVTRFLHRCESAGTSQITTLPLPTLFGNNHMKMDVACKVMLGGKNVEDG
             1840      1850      1860      1870      1880      1890

      2390      2400      2410      2420      2430      2440       
pF1KA0 FGIAFRVLQDFQLDAAMTYCRAARQLVEKEKYSEIQQLLKCVSESGMAAKSDGDTILLNC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FGIAFRVLQDFQLDAAMTYCRAARQLVEKEKYSEIQQLLKCVSESGMAAKSDGDTILLNC
             1900      1910      1920      1930      1940      1950

      2450      2460      2470      2480      2490      2500       
pF1KA0 LEAFKRIPPQELEGLIQAIHNDDNKVRAYLICCKLRSAYLIAVKQEHSRATALVQQVQQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEAFKRIPPQELEGLIQAIHNDDNKVRAYLICCKLRSAYLIAVKQEHSRATALVQQVQQA
             1960      1970      1980      1990      2000      2010

      2510      2520      2530         
pF1KA0 AKSSGDAVVQDICAQWLLTSHPRGAHGPGSRK
       ::::::::::::::::::::::::::::::::
XP_016 AKSSGDAVVQDICAQWLLTSHPRGAHGPGSRK
             2020      2030      2040  

>>XP_016876616 (OMIM: 270700,612012) PREDICTED: zinc fin  (1770 aa)
 initn: 6344 init1: 6344 opt: 11685  Z-score: 9613.7  bits: 1792.5 E(85289):    0
Smith-Waterman score: 11685; 99.5% identity (99.7% similar) in 1768 aa overlap (778-2539:3-1770)

       750       760       770       780       790       800       
pF1KA0 RSEEQPSRRYQPATRHPSLRRGRRTRRSQADGRDRGSNPSLESTSSELSTSTSEGSLSAM
                                     ::::::::::::::::::::::::::::::
XP_016                             MKDGRDRGSNPSLESTSSELSTSTSEGSLSAM
                                           10        20        30  

       810       820       830       840       850       860       
pF1KA0 SGRNELHSRLHPHPQSSLIPMMFSPPESLLASCILRGNFAEAHQVLFTFNLKSSPSSGEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGRNELHSRLHPHPQSSLIPMMFSPPESLLASCILRGNFAEAHQVLFTFNLKSSPSSGEL
             40        50        60        70        80        90  

       870       880       890       900       910       920       
pF1KA0 MFMERYQEVIQELAQVEHKIENQNSDAGSSTIRRTGSGRSTLQAIGSAAAAGMVFYSISD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MFMERYQEVIQELAQVEHKIENQNSDAGSSTIRRTGSGRSTLQAIGSAAAAGMVFYSISD
            100       110       120       130       140       150  

       930       940       950       960       970       980       
pF1KA0 VTDKLLNTSGDPIPMLQEDFWISTALVEPTAPLREVLEDLSPPAMAAFDLACSQCQLWKT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTDKLLNTSGDPIPMLQEDFWISTALVEPTAPLREVLEDLSPPAMAAFDLACSQCQLWKT
            160       170       180       190       200       210  

       990      1000      1010      1020      1030      1040       
pF1KA0 CKQLLETAERRLNSSLERRGRRIDHVLLNADGIRGFPVVLQQISKSLNYLLMTASQTKSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::
XP_016 CKQLLETAERRLNSSLERRGRRIDHVLLNADGIRGFPVVLQQISKSLNYLLMSASQTKSE
            220       230       240       250       260       270  

      1050      1060      1070      1080      1090      1100       
pF1KA0 SVEEKGGGPPRCSITELLQMCWPSLSEDCVASHTTLSQQLDQVLQSLREALELPEPRTPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVEEKGGGPPRCSITELLQMCWPSLSEDCVASHTTLSQQLDQVLQSLREALELPEPRTPP
            280       290       300       310       320       330  

      1110      1120      1130      1140      1150      1160       
pF1KA0 LSSLVEQAAQKAPEAEAHPVQIQTQLLQKNLGKQTPSGSRQMDYLGTFFSYCSTLAAVLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSSLVEQAAQKAPEAEAHPVQIQTQLLQKNLGKQTPSGSRQMDYLGTFFSYCSTLAAVLL
            340       350       360       370       380       390  

      1170      1180      1190      1200      1210      1220       
pF1KA0 QSLSSEPDHVEVKVGNPFVLLQQSSSQLVSHLLFERQVPPERLAALLAQENLSLSVPQVI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSLSSEPDHVEVKVGNPFVLLQQSSSQLVSHLLFERQVPPERLAALLAQENLSLSVPQVI
            400       410       420       430       440       450  

      1230      1240      1250      1260      1270      1280       
pF1KA0 VSCCCEPLALCSSRQSQQTSSLLTRLGTLAQLHASHCLDDLPLSTPSSPRTTENPTLERK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSCCCEPLALCSSRQSQQTSSLLTRLGTLAQLHASHCLDDLPLSTPSSPRTTENPTLERK
            460       470       480       490       500       510  

      1290      1300      1310      1320      1330      1340       
pF1KA0 PYSSPRDSSLPALTSSALAFLKSRSKLLATVACLGASPRLKVSKPSLSWKELRGRREVPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PYSSPRDSSLPALTSSALAFLKSRSKLLATVACLGASPRLKVSKPSLSWKELRGRREVPL
            520       530       540       550       560       570  

      1350      1360      1370      1380      1390      1400       
pF1KA0 AAEQVARECERLLEQFPLFEAFLLAAWEPLRGSLQQGQSLAVNLCGWASLSTVLLGLHSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAEQVARECERLLEQFPLFEAFLLAAWEPLRGSLQQGQSLAVNLCGWASLSTVLLGLHSP
            580       590       600       610       620       630  

      1410      1420      1430      1440      1450      1460       
pF1KA0 IALDVLSEAFEESLVARDWSRALQLTEVYGRDVDDLSSIKDAVLSCAVACDKEGWQYLFP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IALDVLSEAFEESLVARDWSRALQLTEVYGRDVDDLSSIKDAVLSCAVACDKEGWQYLFP
            640       650       660       670       680       690  

      1470      1480      1490      1500      1510      1520       
pF1KA0 VKDASLRSRLALQFVDRWPLESCLEILAYCISDTAVQEGLKCELQRKLAELQVYQKILGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKDASLRSRLALQFVDRWPLESCLEILAYCISDTAVQEGLKCELQRKLAELQVYQKILGL
            700       710       720       730       740       750  

      1530      1540      1550      1560      1570      1580       
pF1KA0 QSPPVWCDWQTLRSCCVEDPSTVMNMILEAQEYELCEEWGCLYPIPREHLISLHQKHLLH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSPPVWCDWQTLRSCCVEDPSTVMNMILEAQEYELCEEWGCLYPIPREHLISLHQKHLLH
            760       770       780       790       800       810  

      1590      1600      1610      1620      1630      1640       
pF1KA0 LLERRDHDKALQLLRRIPDPTMCLEVTEQSLDQHTSLATSHFLANYLTTHFYGQLTAVRH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLERRDHDKALQLLRRIPDPTMCLEVTEQSLDQHTSLATSHFLANYLTTHFYGQLTAVRH
            820       830       840       850       860       870  

      1650      1660      1670      1680      1690      1700       
pF1KA0 REIQALYVGSKILLTLPEQHRASYSHLSSNPLFMLEQLLMNMKVDWATVAVQTLQQLLVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 REIQALYVGSKILLTLPEQHRASYSHLSSNPLFMLEQLLMNMKVDWATVAVQTLQQLLVG
            880       890       900       910       920       930  

      1710      1720      1730      1740            1750      1760 
pF1KA0 QEIGFTMDEVDSLLSRYAEKALDFPYPQREKRS------DSVIHLQEIVHQAADPETLPR
       :::::::::::::::::::::::::::::::::      :::::::::::::::::::::
XP_016 QEIGFTMDEVDSLLSRYAEKALDFPYPQREKRSAFSLSTDSVIHLQEIVHQAADPETLPR
            940       950       960       970       980       990  

            1770      1780      1790      1800      1810      1820 
pF1KA0 SPSAEFSPAAPPGISSIHSPSLRERSFPPTQPSQEFVPPATPPARHQWVPDETESICMVC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPSAEFSPAAPPGISSIHSPSLRERSFPPTQPSQEFVPPATPPARHQWVPDETESICMVC
           1000      1010      1020      1030      1040      1050  

            1830      1840      1850      1860      1870      1880 
pF1KA0 CREHFTMFNRRHHCRRCGRLVCSSCSTKKMVVEGCRENPARVCDQCYSYCNKDVPEEPSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CREHFTMFNRRHHCRRCGRLVCSSCSTKKMVVEGCRENPARVCDQCYSYCNKDVPEEPSE
           1060      1070      1080      1090      1100      1110  

            1890      1900      1910      1920      1930      1940 
pF1KA0 KPEALDSSKSESPPYSFVVRVPKADEVEWILDLKEEENELVRSEFYYEQAPSASLCIAIL
       :::::::::.::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPEALDSSKNESPPYSFVVRVPKADEVEWILDLKEEENELVRSEFYYEQAPSASLCIAIL
           1120      1130      1140      1150      1160      1170  

            1950      1960      1970      1980      1990      2000 
pF1KA0 NLHRDSIACGHQLIEHCCRLSKGLTNPEVDAGLLTDIMKQLLFSAKMMFVKAGQSQDLAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NLHRDSIACGHQLIEHCCRLSKGLTNPEVDAGLLTDIMKQLLFSAKMMFVKAGQSQDLAL
           1180      1190      1200      1210      1220      1230  

            2010      2020      2030      2040      2050      2060 
pF1KA0 CDSYISKVDVLNILVAAAYRHVPSLDQILQPAAVTRLRNQLLEAEYYQLGVEVSTKTGLD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CDSYISKVDVLNILVAAAYRHVPSLDQILQPAAVTRLRNQLLEAEYYQLGVEVSTKTGLD
           1240      1250      1260      1270      1280      1290  

            2070      2080      2090      2100      2110      2120 
pF1KA0 TTGAWHAWGMACLKAGNLTAAREKFSRCLKPPFDLNQLNHGSRLVQDVVEYLESTVRPFV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TTGAWHAWGMACLKAGNLTAAREKFSRCLKPPFDLNQLNHGSRLVQDVVEYLESTVRPFV
           1300      1310      1320      1330      1340      1350  

            2130      2140      2150      2160      2170      2180 
pF1KA0 SLQDDDYFATLRELEATLRTQSLSLAVIPEGKIMNNTYYQECLFYLHNYSTNLAIISFYV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLQDDDYFATLRELEATLRTQSLSLAVIPEGKIMNNTYYQECLFYLHNYSTNLAIISFYV
           1360      1370      1380      1390      1400      1410  

            2190      2200      2210      2220      2230      2240 
pF1KA0 RHSCLREALLHLLNKESPPEVFIEGIFQPSYKSGKLHTLENLLESIDPTLESWGKYLIAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RHSCLREALLHLLNKESPPEVFIEGIFQPSYKSGKLHTLENLLESIDPTLESWGKYLIAA
           1420      1430      1440      1450      1460      1470  

            2250      2260      2270      2280      2290      2300 
pF1KA0 CQHLQKKNYYHILYELQQFMKDQVRAAMTCIRFFSHKAKSYTELGEKLSWLLKAKDHLKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CQHLQKKNYYHILYELQQFMKDQVRAAMTCIRFFSHKAKSYTELGEKLSWLLKAKDHLKI
           1480      1490      1500      1510      1520      1530  

            2310      2320      2330      2340      2350      2360 
pF1KA0 YLQETSRSSGRKKTTFFRKKMTAADVSRHMNTLQLQMEVTRFLHRCESAGTSQITTLPLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YLQETSRSSGRKKTTFFRKKMTAADVSRHMNTLQLQMEVTRFLHRCESAGTSQITTLPLP
           1540      1550      1560      1570      1580      1590  

            2370      2380      2390      2400      2410      2420 
pF1KA0 TLFGNNHMKMDVACKVMLGGKNVEDGFGIAFRVLQDFQLDAAMTYCRAARQLVEKEKYSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLFGNNHMKMDVACKVMLGGKNVEDGFGIAFRVLQDFQLDAAMTYCRAARQLVEKEKYSE
           1600      1610      1620      1630      1640      1650  

            2430      2440      2450      2460      2470      2480 
pF1KA0 IQQLLKCVSESGMAAKSDGDTILLNCLEAFKRIPPQELEGLIQAIHNDDNKVRAYLICCK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IQQLLKCVSESGMAAKSDGDTILLNCLEAFKRIPPQELEGLIQAIHNDDNKVRAYLICCK
           1660      1670      1680      1690      1700      1710  

            2490      2500      2510      2520      2530         
pF1KA0 LRSAYLIAVKQEHSRATALVQQVQQAAKSSGDAVVQDICAQWLLTSHPRGAHGPGSRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRSAYLIAVKQEHSRATALVQQVQQAAKSSGDAVVQDICAQWLLTSHPRGAHGPGSRK
           1720      1730      1740      1750      1760      1770

>>XP_016876617 (OMIM: 270700,612012) PREDICTED: zinc fin  (1739 aa)
 initn: 6170 init1: 6170 opt: 11511  Z-score: 9470.6  bits: 1766.0 E(85289):    0
Smith-Waterman score: 11511; 99.5% identity (99.7% similar) in 1739 aa overlap (807-2539:1-1739)

        780       790       800       810       820       830      
pF1KA0 ADGRDRGSNPSLESTSSELSTSTSEGSLSAMSGRNELHSRLHPHPQSSLIPMMFSPPESL
                                     ::::::::::::::::::::::::::::::
XP_016                               MSGRNELHSRLHPHPQSSLIPMMFSPPESL
                                             10        20        30

        840       850       860       870       880       890      
pF1KA0 LASCILRGNFAEAHQVLFTFNLKSSPSSGELMFMERYQEVIQELAQVEHKIENQNSDAGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LASCILRGNFAEAHQVLFTFNLKSSPSSGELMFMERYQEVIQELAQVEHKIENQNSDAGS
               40        50        60        70        80        90

        900       910       920       930       940       950      
pF1KA0 STIRRTGSGRSTLQAIGSAAAAGMVFYSISDVTDKLLNTSGDPIPMLQEDFWISTALVEP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 STIRRTGSGRSTLQAIGSAAAAGMVFYSISDVTDKLLNTSGDPIPMLQEDFWISTALVEP
              100       110       120       130       140       150

        960       970       980       990      1000      1010      
pF1KA0 TAPLREVLEDLSPPAMAAFDLACSQCQLWKTCKQLLETAERRLNSSLERRGRRIDHVLLN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TAPLREVLEDLSPPAMAAFDLACSQCQLWKTCKQLLETAERRLNSSLERRGRRIDHVLLN
              160       170       180       190       200       210

       1020      1030      1040      1050      1060      1070      
pF1KA0 ADGIRGFPVVLQQISKSLNYLLMTASQTKSESVEEKGGGPPRCSITELLQMCWPSLSEDC
       :::::::::::::::::::::::.::::::::::::::::::::::::::::::::::::
XP_016 ADGIRGFPVVLQQISKSLNYLLMSASQTKSESVEEKGGGPPRCSITELLQMCWPSLSEDC
              220       230       240       250       260       270

       1080      1090      1100      1110      1120      1130      
pF1KA0 VASHTTLSQQLDQVLQSLREALELPEPRTPPLSSLVEQAAQKAPEAEAHPVQIQTQLLQK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VASHTTLSQQLDQVLQSLREALELPEPRTPPLSSLVEQAAQKAPEAEAHPVQIQTQLLQK
              280       290       300       310       320       330

       1140      1150      1160      1170      1180      1190      
pF1KA0 NLGKQTPSGSRQMDYLGTFFSYCSTLAAVLLQSLSSEPDHVEVKVGNPFVLLQQSSSQLV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NLGKQTPSGSRQMDYLGTFFSYCSTLAAVLLQSLSSEPDHVEVKVGNPFVLLQQSSSQLV
              340       350       360       370       380       390

       1200      1210      1220      1230      1240      1250      
pF1KA0 SHLLFERQVPPERLAALLAQENLSLSVPQVIVSCCCEPLALCSSRQSQQTSSLLTRLGTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SHLLFERQVPPERLAALLAQENLSLSVPQVIVSCCCEPLALCSSRQSQQTSSLLTRLGTL
              400       410       420       430       440       450

       1260      1270      1280      1290      1300      1310      
pF1KA0 AQLHASHCLDDLPLSTPSSPRTTENPTLERKPYSSPRDSSLPALTSSALAFLKSRSKLLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQLHASHCLDDLPLSTPSSPRTTENPTLERKPYSSPRDSSLPALTSSALAFLKSRSKLLA
              460       470       480       490       500       510

       1320      1330      1340      1350      1360      1370      
pF1KA0 TVACLGASPRLKVSKPSLSWKELRGRREVPLAAEQVARECERLLEQFPLFEAFLLAAWEP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TVACLGASPRLKVSKPSLSWKELRGRREVPLAAEQVARECERLLEQFPLFEAFLLAAWEP
              520       530       540       550       560       570

       1380      1390      1400      1410      1420      1430      
pF1KA0 LRGSLQQGQSLAVNLCGWASLSTVLLGLHSPIALDVLSEAFEESLVARDWSRALQLTEVY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRGSLQQGQSLAVNLCGWASLSTVLLGLHSPIALDVLSEAFEESLVARDWSRALQLTEVY
              580       590       600       610       620       630

       1440      1450      1460      1470      1480      1490      
pF1KA0 GRDVDDLSSIKDAVLSCAVACDKEGWQYLFPVKDASLRSRLALQFVDRWPLESCLEILAY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRDVDDLSSIKDAVLSCAVACDKEGWQYLFPVKDASLRSRLALQFVDRWPLESCLEILAY
              640       650       660       670       680       690

       1500      1510      1520      1530      1540      1550      
pF1KA0 CISDTAVQEGLKCELQRKLAELQVYQKILGLQSPPVWCDWQTLRSCCVEDPSTVMNMILE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CISDTAVQEGLKCELQRKLAELQVYQKILGLQSPPVWCDWQTLRSCCVEDPSTVMNMILE
              700       710       720       730       740       750

       1560      1570      1580      1590      1600      1610      
pF1KA0 AQEYELCEEWGCLYPIPREHLISLHQKHLLHLLERRDHDKALQLLRRIPDPTMCLEVTEQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQEYELCEEWGCLYPIPREHLISLHQKHLLHLLERRDHDKALQLLRRIPDPTMCLEVTEQ
              760       770       780       790       800       810

       1620      1630      1640      1650      1660      1670      
pF1KA0 SLDQHTSLATSHFLANYLTTHFYGQLTAVRHREIQALYVGSKILLTLPEQHRASYSHLSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLDQHTSLATSHFLANYLTTHFYGQLTAVRHREIQALYVGSKILLTLPEQHRASYSHLSS
              820       830       840       850       860       870

       1680      1690      1700      1710      1720      1730      
pF1KA0 NPLFMLEQLLMNMKVDWATVAVQTLQQLLVGQEIGFTMDEVDSLLSRYAEKALDFPYPQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NPLFMLEQLLMNMKVDWATVAVQTLQQLLVGQEIGFTMDEVDSLLSRYAEKALDFPYPQR
              880       890       900       910       920       930

       1740            1750      1760      1770      1780      1790
pF1KA0 EKRS------DSVIHLQEIVHQAADPETLPRSPSAEFSPAAPPGISSIHSPSLRERSFPP
       ::::      ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKRSAFSLSTDSVIHLQEIVHQAADPETLPRSPSAEFSPAAPPGISSIHSPSLRERSFPP
              940       950       960       970       980       990

             1800      1810      1820      1830      1840      1850
pF1KA0 TQPSQEFVPPATPPARHQWVPDETESICMVCCREHFTMFNRRHHCRRCGRLVCSSCSTKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TQPSQEFVPPATPPARHQWVPDETESICMVCCREHFTMFNRRHHCRRCGRLVCSSCSTKK
             1000      1010      1020      1030      1040      1050

             1860      1870      1880      1890      1900      1910
pF1KA0 MVVEGCRENPARVCDQCYSYCNKDVPEEPSEKPEALDSSKSESPPYSFVVRVPKADEVEW
       ::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::
XP_016 MVVEGCRENPARVCDQCYSYCNKDVPEEPSEKPEALDSSKNESPPYSFVVRVPKADEVEW
             1060      1070      1080      1090      1100      1110

             1920      1930      1940      1950      1960      1970
pF1KA0 ILDLKEEENELVRSEFYYEQAPSASLCIAILNLHRDSIACGHQLIEHCCRLSKGLTNPEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILDLKEEENELVRSEFYYEQAPSASLCIAILNLHRDSIACGHQLIEHCCRLSKGLTNPEV
             1120      1130      1140      1150      1160      1170

             1980      1990      2000      2010      2020      2030
pF1KA0 DAGLLTDIMKQLLFSAKMMFVKAGQSQDLALCDSYISKVDVLNILVAAAYRHVPSLDQIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DAGLLTDIMKQLLFSAKMMFVKAGQSQDLALCDSYISKVDVLNILVAAAYRHVPSLDQIL
             1180      1190      1200      1210      1220      1230

             2040      2050      2060      2070      2080      2090
pF1KA0 QPAAVTRLRNQLLEAEYYQLGVEVSTKTGLDTTGAWHAWGMACLKAGNLTAAREKFSRCL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPAAVTRLRNQLLEAEYYQLGVEVSTKTGLDTTGAWHAWGMACLKAGNLTAAREKFSRCL
             1240      1250      1260      1270      1280      1290

             2100      2110      2120      2130      2140      2150
pF1KA0 KPPFDLNQLNHGSRLVQDVVEYLESTVRPFVSLQDDDYFATLRELEATLRTQSLSLAVIP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPPFDLNQLNHGSRLVQDVVEYLESTVRPFVSLQDDDYFATLRELEATLRTQSLSLAVIP
             1300      1310      1320      1330      1340      1350

             2160      2170      2180      2190      2200      2210
pF1KA0 EGKIMNNTYYQECLFYLHNYSTNLAIISFYVRHSCLREALLHLLNKESPPEVFIEGIFQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGKIMNNTYYQECLFYLHNYSTNLAIISFYVRHSCLREALLHLLNKESPPEVFIEGIFQP
             1360      1370      1380      1390      1400      1410

             2220      2230      2240      2250      2260      2270
pF1KA0 SYKSGKLHTLENLLESIDPTLESWGKYLIAACQHLQKKNYYHILYELQQFMKDQVRAAMT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SYKSGKLHTLENLLESIDPTLESWGKYLIAACQHLQKKNYYHILYELQQFMKDQVRAAMT
             1420      1430      1440      1450      1460      1470

             2280      2290      2300      2310      2320      2330
pF1KA0 CIRFFSHKAKSYTELGEKLSWLLKAKDHLKIYLQETSRSSGRKKTTFFRKKMTAADVSRH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CIRFFSHKAKSYTELGEKLSWLLKAKDHLKIYLQETSRSSGRKKTTFFRKKMTAADVSRH
             1480      1490      1500      1510      1520      1530

             2340      2350      2360      2370      2380      2390
pF1KA0 MNTLQLQMEVTRFLHRCESAGTSQITTLPLPTLFGNNHMKMDVACKVMLGGKNVEDGFGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNTLQLQMEVTRFLHRCESAGTSQITTLPLPTLFGNNHMKMDVACKVMLGGKNVEDGFGI
             1540      1550      1560      1570      1580      1590

             2400      2410      2420      2430      2440      2450
pF1KA0 AFRVLQDFQLDAAMTYCRAARQLVEKEKYSEIQQLLKCVSESGMAAKSDGDTILLNCLEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AFRVLQDFQLDAAMTYCRAARQLVEKEKYSEIQQLLKCVSESGMAAKSDGDTILLNCLEA
             1600      1610      1620      1630      1640      1650

             2460      2470      2480      2490      2500      2510
pF1KA0 FKRIPPQELEGLIQAIHNDDNKVRAYLICCKLRSAYLIAVKQEHSRATALVQQVQQAAKS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FKRIPPQELEGLIQAIHNDDNKVRAYLICCKLRSAYLIAVKQEHSRATALVQQVQQAAKS
             1660      1670      1680      1690      1700      1710

             2520      2530         
pF1KA0 SGDAVVQDICAQWLLTSHPRGAHGPGSRK
       :::::::::::::::::::::::::::::
XP_016 SGDAVVQDICAQWLLTSHPRGAHGPGSRK
             1720      1730         

>>XP_011534911 (OMIM: 270700,612012) PREDICTED: zinc fin  (1666 aa)
 initn: 11130 init1: 11130 opt: 11130  Z-score: 9157.4  bits: 1708.0 E(85289):    0
Smith-Waterman score: 11130; 99.9% identity (99.9% similar) in 1659 aa overlap (1-1659:1-1659)

               10        20        30        40        50        60
pF1KA0 MNHPFGKEEAASQKQLFGFFCECLRRGEWELAQACVPQLQEGQGDIPKRVEDILQALVVC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MNHPFGKEEAASQKQLFGFFCECLRRGEWELAQACVPQLQEGQGDIPKRVEDILQALVVC
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 PNLLRCGQDINPQRVAWVWLLVLEKWLAREKKLLPVVFRRKLEFLLLSEDLQGDIPENIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PNLLRCGQDINPQRVAWVWLLVLEKWLAREKKLLPVVFRRKLEFLLLSEDLQGDIPENIL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 EELYETLTQGAVGHVPDGNPRRESWTPRLSSEAVSVLWDLLRQSPQPAQALLELLLEEDD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EELYETLTQGAVGHVPDGNPRRESWTPRLSSEAVSVLWDLLRQSPQPAQALLELLLEEDD
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 GTGLCHWPLQNALVDLIRKALRALQGPDSVPPGVVDAIYGALRTLRCPAEPLGVELHLLC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GTGLCHWPLQNALVDLIRKALRALQGPDSVPPGVVDAIYGALRTLRCPAEPLGVELHLLC
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA0 EELLEACRTEGSPLREERLLSCLLHKASRGLLSLYGHTYAEKVTEKPPRATASGKVSPDH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EELLEACRTEGSPLREERLLSCLLHKASRGLLSLYGHTYAEKVTEKPPRATASGKVSPDH
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA0 LDPERAMLALFSNPNPAEAWKVAYFYCLSNNKHFLEQILVTALTLLKEEDFPNLGCLLDR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDPERAMLALFSNPNPAEAWKVAYFYCLSNNKHFLEQILVTALTLLKEEDFPNLGCLLDR
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA0 EFRPLSCLLVLLGWTHCQSLESAKRLLQTLHRTQGPGCDELLRDACDGLWAHLEVLEWCI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EFRPLSCLLVLLGWTHCQSLESAKRLLQTLHRTQGPGCDELLRDACDGLWAHLEVLEWCI
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KA0 QQSSNPIPKRDLLYHLHGGDSHSVLYTLHHLTNLPALREEDVLKLLQKVPAKDPQQEPDA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQSSNPIPKRDLLYHLHGGDSHSVLYTLHHLTNLPALREEDVLKLLQKVPAKDPQQEPDA
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KA0 VDAPVPEHLSQCQNLTLYQGFCAMKYAIYALCVNSHQHSQCQDCKDSLSEDLASATEPAN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VDAPVPEHLSQCQNLTLYQGFCAMKYAIYALCVNSHQHSQCQDCKDSLSEDLASATEPAN
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KA0 DSLSSPGAANLFSTYPARCQQYLCSIPDSLCLELLENIFSLLLITSADLHPEPHLPEDYA
       ::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::
XP_011 DSLSSPGAANLFSTYLARCQQYLCSIPDSLCLELLENIFSLLLITSADLHPEPHLPEDYA
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KA0 EDDDIEGKSPSGLRSPSESPQHIAHPERKSERGSLGVPKTLAYTMPSHVKAEPKDSYPGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDDDIEGKSPSGLRSPSESPQHIAHPERKSERGSLGVPKTLAYTMPSHVKAEPKDSYPGP
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KA0 HRHSFLDLKHFTSGISGFLADEFAIGAFLRLLQEQLDEISSRSPPEKPKQESQSCSGSRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HRHSFLDLKHFTSGISGFLADEFAIGAFLRLLQEQLDEISSRSPPEKPKQESQSCSGSRD
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KA0 GLQSRLHRLSKVVSEAQWRHKVVTSNHRSEEQPSRRYQPATRHPSLRRGRRTRRSQADGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLQSRLHRLSKVVSEAQWRHKVVTSNHRSEEQPSRRYQPATRHPSLRRGRRTRRSQADGR
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KA0 DRGSNPSLESTSSELSTSTSEGSLSAMSGRNELHSRLHPHPQSSLIPMMFSPPESLLASC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DRGSNPSLESTSSELSTSTSEGSLSAMSGRNELHSRLHPHPQSSLIPMMFSPPESLLASC
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KA0 ILRGNFAEAHQVLFTFNLKSSPSSGELMFMERYQEVIQELAQVEHKIENQNSDAGSSTIR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ILRGNFAEAHQVLFTFNLKSSPSSGELMFMERYQEVIQELAQVEHKIENQNSDAGSSTIR
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KA0 RTGSGRSTLQAIGSAAAAGMVFYSISDVTDKLLNTSGDPIPMLQEDFWISTALVEPTAPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTGSGRSTLQAIGSAAAAGMVFYSISDVTDKLLNTSGDPIPMLQEDFWISTALVEPTAPL
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KA0 REVLEDLSPPAMAAFDLACSQCQLWKTCKQLLETAERRLNSSLERRGRRIDHVLLNADGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 REVLEDLSPPAMAAFDLACSQCQLWKTCKQLLETAERRLNSSLERRGRRIDHVLLNADGI
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KA0 RGFPVVLQQISKSLNYLLMTASQTKSESVEEKGGGPPRCSITELLQMCWPSLSEDCVASH
       :::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::
XP_011 RGFPVVLQQISKSLNYLLMSASQTKSESVEEKGGGPPRCSITELLQMCWPSLSEDCVASH
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KA0 TTLSQQLDQVLQSLREALELPEPRTPPLSSLVEQAAQKAPEAEAHPVQIQTQLLQKNLGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TTLSQQLDQVLQSLREALELPEPRTPPLSSLVEQAAQKAPEAEAHPVQIQTQLLQKNLGK
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KA0 QTPSGSRQMDYLGTFFSYCSTLAAVLLQSLSSEPDHVEVKVGNPFVLLQQSSSQLVSHLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QTPSGSRQMDYLGTFFSYCSTLAAVLLQSLSSEPDHVEVKVGNPFVLLQQSSSQLVSHLL
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KA0 FERQVPPERLAALLAQENLSLSVPQVIVSCCCEPLALCSSRQSQQTSSLLTRLGTLAQLH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FERQVPPERLAALLAQENLSLSVPQVIVSCCCEPLALCSSRQSQQTSSLLTRLGTLAQLH
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KA0 ASHCLDDLPLSTPSSPRTTENPTLERKPYSSPRDSSLPALTSSALAFLKSRSKLLATVAC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASHCLDDLPLSTPSSPRTTENPTLERKPYSSPRDSSLPALTSSALAFLKSRSKLLATVAC
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KA0 LGASPRLKVSKPSLSWKELRGRREVPLAAEQVARECERLLEQFPLFEAFLLAAWEPLRGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LGASPRLKVSKPSLSWKELRGRREVPLAAEQVARECERLLEQFPLFEAFLLAAWEPLRGS
             1330      1340      1350      1360      1370      1380

             1390      1400      1410      1420      1430      1440
pF1KA0 LQQGQSLAVNLCGWASLSTVLLGLHSPIALDVLSEAFEESLVARDWSRALQLTEVYGRDV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQQGQSLAVNLCGWASLSTVLLGLHSPIALDVLSEAFEESLVARDWSRALQLTEVYGRDV
             1390      1400      1410      1420      1430      1440

             1450      1460      1470      1480      1490      1500
pF1KA0 DDLSSIKDAVLSCAVACDKEGWQYLFPVKDASLRSRLALQFVDRWPLESCLEILAYCISD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DDLSSIKDAVLSCAVACDKEGWQYLFPVKDASLRSRLALQFVDRWPLESCLEILAYCISD
             1450      1460      1470      1480      1490      1500

             1510      1520      1530      1540      1550      1560
pF1KA0 TAVQEGLKCELQRKLAELQVYQKILGLQSPPVWCDWQTLRSCCVEDPSTVMNMILEAQEY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TAVQEGLKCELQRKLAELQVYQKILGLQSPPVWCDWQTLRSCCVEDPSTVMNMILEAQEY
             1510      1520      1530      1540      1550      1560

             1570      1580      1590      1600      1610      1620
pF1KA0 ELCEEWGCLYPIPREHLISLHQKHLLHLLERRDHDKALQLLRRIPDPTMCLEVTEQSLDQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELCEEWGCLYPIPREHLISLHQKHLLHLLERRDHDKALQLLRRIPDPTMCLEVTEQSLDQ
             1570      1580      1590      1600      1610      1620

             1630      1640      1650      1660      1670      1680
pF1KA0 HTSLATSHFLANYLTTHFYGQLTAVRHREIQALYVGSKILLTLPEQHRASYSHLSSNPLF
       :::::::::::::::::::::::::::::::::::::::                     
XP_011 HTSLATSHFLANYLTTHFYGQLTAVRHREIQALYVGSKIYPTNRFC              
             1630      1640      1650      1660                    

             1690      1700      1710      1720      1730      1740
pF1KA0 MLEQLLMNMKVDWATVAVQTLQQLLVGQEIGFTMDEVDSLLSRYAEKALDFPYPQREKRS

>>XP_011525611 (OMIM: 615200) PREDICTED: pleckstrin homo  (279 aa)
 initn: 245 init1: 245 opt: 283  Z-score: 243.7  bits: 56.1 E(85289): 7.8e-07
Smith-Waterman score: 283; 28.8% identity (59.6% similar) in 156 aa overlap (1735-1885:71-225)

         1710      1720      1730      1740      1750      1760    
pF1KA0 LVGQEIGFTMDEVDSLLSRYAEKALDFPYPQREKRSDSVIHLQEIVHQAADPETLPRSPS
                                     .:. ::. .: :.:.. .   ::::  .  
XP_011 VLTKECRKKAKPRIFFLFNDILVYGSIVLNKRKYRSQHIIPLEEVTLELL-PETLQAKNR
               50        60        70        80        90          

         1770      1780      1790        1800         1810         
pF1KA0 AEFSPAAPPGISSIHSPSLRERSFPPTQPS--QEFVPPATPPARHQ---WVPDETESICM
         .. :    . :  : . :.. .   .    ...   . ::. ..   :.::.. .:::
XP_011 WMIKTAKKSFVVSAASATERQEWISHIEECVRRQLRATGRPPSTEHAAPWIPDKATDICM
     100       110       120       130       140       150         

    1820      1830      1840      1850      1860      1870         
pF1KA0 VCCREHFTMFNRRHHCRRCGRLVCSSCSTKKMVVEGCRENPARVCDQCYSYCNKDVPEEP
        : . .:. ..::::::.:: .::. :: .....     .:.:::. ::     .  .: 
XP_011 RCTQTRFSALTRRHHCRKCGFVVCAECSRQRFLLPRLSPKPVRVCSLCYRELAAQQRQEE
     160       170       180       190       200       210         

    1880      1890      1900      1910      1920      1930         
pF1KA0 SEKPEALDSSKSESPPYSFVVRVPKADEVEWILDLKEEENELVRSEFYYEQAPSASLCIA
       .:.  :                                                      
XP_011 AEEQGAGSPGQPAHLARPICGASSGDDDDSDEDKEGSRDGDWPSSVEFYASGVAWSAFHS
     220       230       240       250       260       270         

>>NP_077286 (OMIM: 615200) pleckstrin homology domain-co  (279 aa)
 initn: 245 init1: 245 opt: 283  Z-score: 243.7  bits: 56.1 E(85289): 7.8e-07
Smith-Waterman score: 283; 28.8% identity (59.6% similar) in 156 aa overlap (1735-1885:71-225)

         1710      1720      1730      1740      1750      1760    
pF1KA0 LVGQEIGFTMDEVDSLLSRYAEKALDFPYPQREKRSDSVIHLQEIVHQAADPETLPRSPS
                                     .:. ::. .: :.:.. .   ::::  .  
NP_077 VLTKECRKKAKPRIFFLFNDILVYGSIVLNKRKYRSQHIIPLEEVTLELL-PETLQAKNR
               50        60        70        80        90          

         1770      1780      1790        1800         1810         
pF1KA0 AEFSPAAPPGISSIHSPSLRERSFPPTQPS--QEFVPPATPPARHQ---WVPDETESICM
         .. :    . :  : . :.. .   .    ...   . ::. ..   :.::.. .:::
NP_077 WMIKTAKKSFVVSAASATERQEWISHIEECVRRQLRATGRPPSTEHAAPWIPDKATDICM
     100       110       120       130       140       150         

    1820      1830      1840      1850      1860      1870         
pF1KA0 VCCREHFTMFNRRHHCRRCGRLVCSSCSTKKMVVEGCRENPARVCDQCYSYCNKDVPEEP
        : . .:. ..::::::.:: .::. :: .....     .:.:::. ::     .  .: 
NP_077 RCTQTRFSALTRRHHCRKCGFVVCAECSRQRFLLPRLSPKPVRVCSLCYRELAAQQRQEE
     160       170       180       190       200       210         

    1880      1890      1900      1910      1920      1930         
pF1KA0 SEKPEALDSSKSESPPYSFVVRVPKADEVEWILDLKEEENELVRSEFYYEQAPSASLCIA
       .:.  :                                                      
NP_077 AEEQGAGSPGQPAHLARPICGASSGDDDDSDEDKEGSRDGDWPSSVEFYASGVAWSAFHS
     220       230       240       250       260       270         

>>XP_005259313 (OMIM: 615200) PREDICTED: pleckstrin homo  (364 aa)
 initn: 278 init1: 245 opt: 283  Z-score: 242.0  bits: 56.2 E(85289): 9.7e-07
Smith-Waterman score: 283; 28.8% identity (59.6% similar) in 156 aa overlap (1735-1885:156-310)

         1710      1720      1730      1740      1750      1760    
pF1KA0 LVGQEIGFTMDEVDSLLSRYAEKALDFPYPQREKRSDSVIHLQEIVHQAADPETLPRSPS
                                     .:. ::. .: :.:.. .   ::::  .  
XP_005 VLTKECRKKAKPRIFFLFNDILVYGSIVLNKRKYRSQHIIPLEEVTLELL-PETLQAKNR
         130       140       150       160       170        180    

         1770      1780      1790        1800         1810         
pF1KA0 AEFSPAAPPGISSIHSPSLRERSFPPTQPS--QEFVPPATPPARHQ---WVPDETESICM
         .. :    . :  : . :.. .   .    ...   . ::. ..   :.::.. .:::
XP_005 WMIKTAKKSFVVSAASATERQEWISHIEECVRRQLRATGRPPSTEHAAPWIPDKATDICM
          190       200       210       220       230       240    

    1820      1830      1840      1850      1860      1870         
pF1KA0 VCCREHFTMFNRRHHCRRCGRLVCSSCSTKKMVVEGCRENPARVCDQCYSYCNKDVPEEP
        : . .:. ..::::::.:: .::. :: .....     .:.:::. ::     .  .: 
XP_005 RCTQTRFSALTRRHHCRKCGFVVCAECSRQRFLLPRLSPKPVRVCSLCYRELAAQQRQEE
          250       260       270       280       290       300    

    1880      1890      1900      1910      1920      1930         
pF1KA0 SEKPEALDSSKSESPPYSFVVRVPKADEVEWILDLKEEENELVRSEFYYEQAPSASLCIA
       .:.  :                                                      
XP_005 AEEQGAGSPGQPAHLARPICGASSGDDDDSDEDKEGSRDGDWPSSVEFYASGVAWSAFHS
          310       320       330       340       350       360    




2539 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Wed Nov  2 18:34:26 2016 done: Wed Nov  2 18:34:30 2016
 Total Scan time: 24.400 Total Display time:  1.560

Function used was FASTA [36.3.4 Apr, 2011]
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