FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5275, 217 aa 1>>>pF1KE5275 217 - 217 aa - 217 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9408+/-0.000348; mu= 16.0454+/- 0.022 mean_var=66.1962+/-13.124, 0's: 0 Z-trim(113.3): 24 B-trim: 0 in 0/54 Lambda= 0.157637 statistics sampled from 22561 (22585) to 22561 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.648), E-opt: 0.2 (0.265), width: 16 Scan time: 5.210 The best scores are: opt bits E(85289) NP_002050 (OMIM: 139240) growth hormone variant is ( 217) 1431 334.0 1.1e-91 NP_000506 (OMIM: 139250,173100,262400,262650,61278 ( 217) 1321 309.0 3.8e-84 NP_066271 (OMIM: 118820) chorionic somatomammotrop ( 217) 1135 266.7 2.1e-71 NP_001308 (OMIM: 150200) chorionic somatomammotrop ( 217) 1129 265.3 5.4e-71 NP_072101 (OMIM: 603515) chorionic somatomammotrop ( 222) 1040 245.1 6.8e-65 NP_072051 (OMIM: 139240) growth hormone variant is ( 256) 998 235.6 5.7e-62 NP_072052 (OMIM: 139240) growth hormone variant is ( 245) 974 230.1 2.4e-60 NP_072050 (OMIM: 139240) growth hormone variant is ( 202) 972 229.6 2.8e-60 NP_072053 (OMIM: 139250,173100,262400,262650,61278 ( 202) 893 211.6 7.3e-55 NP_001307998 (OMIM: 603515) chorionic somatomammot ( 183) 795 189.3 3.4e-48 NP_001307996 (OMIM: 603515) chorionic somatomammot ( 162) 788 187.7 9.4e-48 NP_072054 (OMIM: 139250,173100,262400,262650,61278 ( 177) 748 178.6 5.5e-45 NP_072170 (OMIM: 118820) chorionic somatomammotrop ( 167) 740 176.8 1.9e-44 XP_011522646 (OMIM: 603515) PREDICTED: chorionic s ( 261) 677 162.6 5.4e-40 NP_072102 (OMIM: 603515) chorionic somatomammotrop ( 139) 669 160.6 1.2e-39 NP_001307997 (OMIM: 603515) chorionic somatomammot ( 160) 669 160.6 1.3e-39 NP_072103 (OMIM: 603515) chorionic somatomammotrop ( 199) 668 160.5 1.8e-39 NP_001309 (OMIM: 603515) chorionic somatomammotrop ( 128) 635 152.8 2.3e-37 XP_011522648 (OMIM: 603515) PREDICTED: chorionic s ( 201) 425 105.2 7.9e-23 NP_072171 (OMIM: 118820) chorionic somatomammotrop ( 122) 411 101.9 4.9e-22 XP_011513056 (OMIM: 176760) PREDICTED: prolactin i ( 228) 232 61.4 1.4e-09 XP_011513055 (OMIM: 176760) PREDICTED: prolactin i ( 228) 232 61.4 1.4e-09 NP_001157030 (OMIM: 176760) prolactin precursor [H ( 227) 227 60.2 3.1e-09 NP_000939 (OMIM: 176760) prolactin precursor [Homo ( 227) 227 60.2 3.1e-09 >>NP_002050 (OMIM: 139240) growth hormone variant isofor (217 aa) initn: 1431 init1: 1431 opt: 1431 Z-score: 1766.8 bits: 334.0 E(85289): 1.1e-91 Smith-Waterman score: 1431; 100.0% identity (100.0% similar) in 217 aa overlap (1-217:1-217) 10 20 30 40 50 60 pF1KE5 MAAGSRTSLLLAFGLLCLSWLQEGSAFPTIPLSRLFDNAMLRARRLYQLAYDTYQEFEEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MAAGSRTSLLLAFGLLCLSWLQEGSAFPTIPLSRLFDNAMLRARRLYQLAYDTYQEFEEA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 YILKEQKYSFLQNPQTSLCFSESIPTPSNRVKTQQKSNLELLRISLLLIQSWLEPVQLLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 YILKEQKYSFLQNPQTSLCFSESIPTPSNRVKTQQKSNLELLRISLLLIQSWLEPVQLLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 SVFANSLVYGASDSNVYRHLKDLEEGIQTLMWRLEDGSPRTGQIFNQSYSKFDTKSHNDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SVFANSLVYGASDSNVYRHLKDLEEGIQTLMWRLEDGSPRTGQIFNQSYSKFDTKSHNDD 130 140 150 160 170 180 190 200 210 pF1KE5 ALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF ::::::::::::::::::::::::::::::::::::: NP_002 ALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF 190 200 210 >>NP_000506 (OMIM: 139250,173100,262400,262650,612781) s (217 aa) initn: 1321 init1: 1321 opt: 1321 Z-score: 1631.6 bits: 309.0 E(85289): 3.8e-84 Smith-Waterman score: 1321; 93.1% identity (97.2% similar) in 217 aa overlap (1-217:1-217) 10 20 30 40 50 60 pF1KE5 MAAGSRTSLLLAFGLLCLSWLQEGSAFPTIPLSRLFDNAMLRARRLYQLAYDTYQEFEEA ::.::::::::::::::: ::::::::::::::::::::::::.::.:::.::::::::: NP_000 MATGSRTSLLLAFGLLCLPWLQEGSAFPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 YILKEQKYSFLQNPQTSLCFSESIPTPSNRVKTQQKSNLELLRISLLLIQSWLEPVQLLR :: ::::::::::::::::::::::::::: .:::::::::::::::::::::::::.:: NP_000 YIPKEQKYSFLQNPQTSLCFSESIPTPSNREETQQKSNLELLRISLLLIQSWLEPVQFLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 SVFANSLVYGASDSNVYRHLKDLEEGIQTLMWRLEDGSPRTGQIFNQSYSKFDTKSHNDD ::::::::::::::::: :::::::::::: :::::::::::::.:.::::::.::::: NP_000 SVFANSLVYGASDSNVYDLLKDLEEGIQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDD 130 140 150 160 170 180 190 200 210 pF1KE5 ALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF ::::::::::::::::::::::::::::::::::::: NP_000 ALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF 190 200 210 >>NP_066271 (OMIM: 118820) chorionic somatomammotropin h (217 aa) initn: 1135 init1: 1135 opt: 1135 Z-score: 1403.0 bits: 266.7 E(85289): 2.1e-71 Smith-Waterman score: 1135; 80.2% identity (93.1% similar) in 217 aa overlap (1-217:1-217) 10 20 30 40 50 60 pF1KE5 MAAGSRTSLLLAFGLLCLSWLQEGSAFPTIPLSRLFDNAMLRARRLYQLAYDTYQEFEEA :::::::::::::.:::: ::::..: :.:::::::.:::.:.: .::: ::::::::. NP_066 MAAGSRTSLLLAFALLCLPWLQEAGAVQTVPLSRLFDHAMLQAHRAHQLAIDTYQEFEET 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 YILKEQKYSFLQNPQTSLCFSESIPTPSNRVKTQQKSNLELLRISLLLIQSWLEPVQLLR :: :.::::::.. :::.:::.::::::: .:::::::::::::::::.::::::..:: NP_066 YIPKDQKYSFLHDSQTSFCFSDSIPTPSNMEETQQKSNLELLRISLLLIESWLEPVRFLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 SVFANSLVYGASDSNVYRHLKDLEEGIQTLMWRLEDGSPRTGQIFNQSYSKFDTKSHNDD :.:::.::: .:::. :. :::::::::::: :::::: :::::..:.::::::.::: : NP_066 SMFANNLVYDTSDSDDYHLLKDLEEGIQTLMGRLEDGSRRTGQILKQTYSKFDTNSHNHD 130 140 150 160 170 180 190 200 210 pF1KE5 ALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF ::::::::::::::::::::::::.:::::::::::: NP_066 ALLKNYGLLYCFRKDMDKVETFLRMVQCRSVEGSCGF 190 200 210 >>NP_001308 (OMIM: 150200) chorionic somatomammotropin h (217 aa) initn: 1129 init1: 1129 opt: 1129 Z-score: 1395.6 bits: 265.3 E(85289): 5.4e-71 Smith-Waterman score: 1129; 79.7% identity (92.6% similar) in 217 aa overlap (1-217:1-217) 10 20 30 40 50 60 pF1KE5 MAAGSRTSLLLAFGLLCLSWLQEGSAFPTIPLSRLFDNAMLRARRLYQLAYDTYQEFEEA :: ::::::::::.:::: ::::..: :.:::::::.:::.:.: .::: ::::::::. NP_001 MAPGSRTSLLLAFALLCLPWLQEAGAVQTVPLSRLFDHAMLQAHRAHQLAIDTYQEFEET 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 YILKEQKYSFLQNPQTSLCFSESIPTPSNRVKTQQKSNLELLRISLLLIQSWLEPVQLLR :: :.::::::.. :::.:::.::::::: .:::::::::::::::::.::::::..:: NP_001 YIPKDQKYSFLHDSQTSFCFSDSIPTPSNMEETQQKSNLELLRISLLLIESWLEPVRFLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 SVFANSLVYGASDSNVYRHLKDLEEGIQTLMWRLEDGSPRTGQIFNQSYSKFDTKSHNDD :.:::.::: .:::. :. :::::::::::: :::::: :::::..:.::::::.::: : NP_001 SMFANNLVYDTSDSDDYHLLKDLEEGIQTLMGRLEDGSRRTGQILKQTYSKFDTNSHNHD 130 140 150 160 170 180 190 200 210 pF1KE5 ALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF ::::::::::::::::::::::::.:::::::::::: NP_001 ALLKNYGLLYCFRKDMDKVETFLRMVQCRSVEGSCGF 190 200 210 >>NP_072101 (OMIM: 603515) chorionic somatomammotropin h (222 aa) initn: 1048 init1: 788 opt: 1040 Z-score: 1286.1 bits: 245.1 E(85289): 6.8e-65 Smith-Waterman score: 1040; 74.8% identity (87.8% similar) in 222 aa overlap (1-217:1-222) 10 20 30 40 50 pF1KE5 MAAGSRTSLLLAFGLLCLSWLQEGSAFPTIPLSRLFDNAMLRARRLYQLAYDTYQEF--- :::::::::::::.:::: ::::..: :.:::::: .:::.:.: .::: :::::: NP_072 MAAGSRTSLLLAFALLCLPWLQEAGAVQTVPLSRLFKEAMLQAHRAHQLAIDTYQEFISS 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE5 --EEAYILKEQKYSFLQNPQTSLCFSESIPTPSNRVKTQQKSNLELLRISLLLIQSWLEP :::: ::::::::.. :::.:::.:::: :: .::::::::::.::::::.: ::: NP_072 WGMEAYITKEQKYSFLHDSQTSFCFSDSIPTSSNMEETQQKSNLELLHISLLLIESRLEP 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE5 VQLLRSVFANSLVYGASDSNVYRHLKDLEEGIQTLMWRLEDGSPRTGQIFNQSYSKFDTK :..:::.:.:.::: .:::. :. ::::::::: :: :::::: ::: ..:.::::::. NP_072 VRFLRSTFTNNLVYDTSDSDDYHLLKDLEEGIQMLMGRLEDGSHLTGQTLKQTYSKFDTN 130 140 150 160 170 180 180 190 200 210 pF1KE5 SHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF ::: ::::::::::.::::::::::::::.:::::::::::: NP_072 SHNHDALLKNYGLLHCFRKDMDKVETFLRMVQCRSVEGSCGF 190 200 210 220 >>NP_072051 (OMIM: 139240) growth hormone variant isofor (256 aa) initn: 983 init1: 983 opt: 998 Z-score: 1233.6 bits: 235.6 E(85289): 5.7e-62 Smith-Waterman score: 998; 95.7% identity (96.3% similar) in 163 aa overlap (1-162:1-163) 10 20 30 40 50 60 pF1KE5 MAAGSRTSLLLAFGLLCLSWLQEGSAFPTIPLSRLFDNAMLRARRLYQLAYDTYQEFEEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_072 MAAGSRTSLLLAFGLLCLSWLQEGSAFPTIPLSRLFDNAMLRARRLYQLAYDTYQEFEEA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 YILKEQKYSFLQNPQTSLCFSESIPTPSNRVKTQQKSNLELLRISLLLIQSWLEPVQLLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_072 YILKEQKYSFLQNPQTSLCFSESIPTPSNRVKTQQKSNLELLRISLLLIQSWLEPVQLLR 70 80 90 100 110 120 130 140 150 160 170 pF1KE5 SVFANSLVYGASDSNVYRHLKDLEEGIQTLMW-RLEDGSPRTGQIFNQSYSKFDTKSHND :::::::::::::::::::::::::::::::: :. : : : NP_072 SVFANSLVYGASDSNVYRHLKDLEEGIQTLMWVRVAPGIPNPGAPLASRDWGEKHCCPLF 130 140 150 160 170 180 180 190 200 210 pF1KE5 DALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF NP_072 SSQALTQENSPYSSFPLVNPPGLSLQPGGEGGKWMNERGREQCPSAWPLLLFLHFAEAGR 190 200 210 220 230 240 >>NP_072052 (OMIM: 139240) growth hormone variant isofor (245 aa) initn: 982 init1: 963 opt: 974 Z-score: 1204.4 bits: 230.1 E(85289): 2.4e-60 Smith-Waterman score: 974; 93.3% identity (97.0% similar) in 164 aa overlap (1-163:1-162) 10 20 30 40 50 60 pF1KE5 MAAGSRTSLLLAFGLLCLSWLQEGSAFPTIPLSRLFDNAMLRARRLYQLAYDTYQEFEEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_072 MAAGSRTSLLLAFGLLCLSWLQEGSAFPTIPLSRLFDNAMLRARRLYQLAYDTYQEFEEA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 YILKEQKYSFLQNPQTSLCFSESIPTPSNRVKTQQKSNLELLRISLLLIQSWLEPVQLLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_072 YILKEQKYSFLQNPQTSLCFSESIPTPSNRVKTQQKSNLELLRISLLLIQSWLEPVQLLR 70 80 90 100 110 120 130 140 150 160 170 pF1KE5 SVFANSLVYGASDSNVYRHLKDLEEGIQTLM-WRLEDGSPRTGQIFNQSYSKFDTKSHND ::::::::::::::::::::::::::::::. :.. ..: :. NP_072 SVFANSLVYGASDSNVYRHLKDLEEGIQTLIGWKM--AAPGLGRSSISPTASLTQNRTTM 130 140 150 160 170 180 190 200 210 pF1KE5 DALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF NP_072 THCSRTTGCSTASGRTWTRSRHSCASCSAALWRAAVASSCPGGIPVTPPQCLSWSWKVLL 180 190 200 210 220 230 >>NP_072050 (OMIM: 139240) growth hormone variant isofor (202 aa) initn: 1324 init1: 965 opt: 972 Z-score: 1203.1 bits: 229.6 E(85289): 2.8e-60 Smith-Waterman score: 1298; 93.1% identity (93.1% similar) in 217 aa overlap (1-217:1-202) 10 20 30 40 50 60 pF1KE5 MAAGSRTSLLLAFGLLCLSWLQEGSAFPTIPLSRLFDNAMLRARRLYQLAYDTYQEFEEA ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_072 MAAGSRTSLLLAFGLLCLSWLQEGSAFPTIPLSRLFDNAMLRARRLYQLAYDTYQEF--- 10 20 30 40 50 70 80 90 100 110 120 pF1KE5 YILKEQKYSFLQNPQTSLCFSESIPTPSNRVKTQQKSNLELLRISLLLIQSWLEPVQLLR :::::::::::::::::::::::::::::::::::::::::::::::: NP_072 ------------NPQTSLCFSESIPTPSNRVKTQQKSNLELLRISLLLIQSWLEPVQLLR 60 70 80 90 100 130 140 150 160 170 180 pF1KE5 SVFANSLVYGASDSNVYRHLKDLEEGIQTLMWRLEDGSPRTGQIFNQSYSKFDTKSHNDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_072 SVFANSLVYGASDSNVYRHLKDLEEGIQTLMWRLEDGSPRTGQIFNQSYSKFDTKSHNDD 110 120 130 140 150 160 190 200 210 pF1KE5 ALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF ::::::::::::::::::::::::::::::::::::: NP_072 ALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF 170 180 190 200 >>NP_072053 (OMIM: 139250,173100,262400,262650,612781) s (202 aa) initn: 1223 init1: 892 opt: 893 Z-score: 1106.0 bits: 211.6 E(85289): 7.3e-55 Smith-Waterman score: 1197; 86.6% identity (90.8% similar) in 217 aa overlap (1-217:1-202) 10 20 30 40 50 60 pF1KE5 MAAGSRTSLLLAFGLLCLSWLQEGSAFPTIPLSRLFDNAMLRARRLYQLAYDTYQEFEEA ::.::::::::::::::: ::::::::::::::::::::::::.::.:::.:::::: NP_072 MATGSRTSLLLAFGLLCLPWLQEGSAFPTIPLSRLFDNAMLRAHRLHQLAFDTYQEF--- 10 20 30 40 50 70 80 90 100 110 120 pF1KE5 YILKEQKYSFLQNPQTSLCFSESIPTPSNRVKTQQKSNLELLRISLLLIQSWLEPVQLLR :::::::::::::::::: .:::::::::::::::::::::::::.:: NP_072 ------------NPQTSLCFSESIPTPSNREETQQKSNLELLRISLLLIQSWLEPVQFLR 60 70 80 90 100 130 140 150 160 170 180 pF1KE5 SVFANSLVYGASDSNVYRHLKDLEEGIQTLMWRLEDGSPRTGQIFNQSYSKFDTKSHNDD ::::::::::::::::: :::::::::::: :::::::::::::.:.::::::.::::: NP_072 SVFANSLVYGASDSNVYDLLKDLEEGIQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDD 110 120 130 140 150 160 190 200 210 pF1KE5 ALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF ::::::::::::::::::::::::::::::::::::: NP_072 ALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF 170 180 190 200 >>NP_001307998 (OMIM: 603515) chorionic somatomammotropi (183 aa) initn: 794 init1: 794 opt: 795 Z-score: 986.1 bits: 189.3 E(85289): 3.4e-48 Smith-Waterman score: 851; 66.8% identity (77.0% similar) in 217 aa overlap (1-217:1-183) 10 20 30 40 50 60 pF1KE5 MAAGSRTSLLLAFGLLCLSWLQEGSAFPTIPLSRLFDNAMLRARRLYQLAYDTYQEFEEA :::::::::::::.:::: :::: ::: NP_001 MAAGSRTSLLLAFALLCLPWLQE----------------------------------EEA 10 20 70 80 90 100 110 120 pF1KE5 YILKEQKYSFLQNPQTSLCFSESIPTPSNRVKTQQKSNLELLRISLLLIQSWLEPVQLLR :: ::::::::.. :::.:::.:::: :: .::::::::::.::::::.: ::::..:: NP_001 YITKEQKYSFLHDSQTSFCFSDSIPTSSNMEETQQKSNLELLHISLLLIESRLEPVRFLR 30 40 50 60 70 80 130 140 150 160 170 180 pF1KE5 SVFANSLVYGASDSNVYRHLKDLEEGIQTLMWRLEDGSPRTGQIFNQSYSKFDTKSHNDD :.:.:.::: .:::. :. ::::::::: :: :::::: ::: ..:.::::::.::: : NP_001 STFTNNLVYDTSDSDDYHLLKDLEEGIQMLMGRLEDGSHLTGQTLKQTYSKFDTNSHNHD 90 100 110 120 130 140 190 200 210 pF1KE5 ALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF :::::::::.::::::::::::::.:::::::::::: NP_001 ALLKNYGLLHCFRKDMDKVETFLRMVQCRSVEGSCGF 150 160 170 180 217 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 07:26:39 2016 done: Tue Nov 8 07:26:40 2016 Total Scan time: 5.210 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]