FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3085, 250 aa 1>>>pF1KE3085 250 - 250 aa - 250 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.7090+/-0.000288; mu= 13.4367+/- 0.018 mean_var=84.4607+/-16.344, 0's: 0 Z-trim(119.4): 13 B-trim: 0 in 0/53 Lambda= 0.139555 statistics sampled from 33272 (33289) to 33272 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.747), E-opt: 0.2 (0.39), width: 16 Scan time: 7.050 The best scores are: opt bits E(85289) NP_003799 (OMIM: 604472) tumor necrosis factor lig ( 250) 1684 348.1 8.6e-96 NP_742085 (OMIM: 604472) tumor necrosis factor lig ( 247) 1661 343.5 2.1e-94 NP_001185553 (OMIM: 604472) tumor necrosis factor ( 205) 928 195.9 4.8e-50 NP_001185552 (OMIM: 604472) tumor necrosis factor ( 222) 928 195.9 5.1e-50 NP_001185551 (OMIM: 604472) tumor necrosis factor ( 223) 926 195.5 6.8e-50 NP_742084 (OMIM: 604472) tumor necrosis factor lig ( 234) 832 176.6 3.5e-44 NP_006564 (OMIM: 603969) tumor necrosis factor lig ( 285) 312 71.9 1.4e-12 NP_001139117 (OMIM: 603969) tumor necrosis factor ( 266) 285 66.5 5.6e-11 XP_006724693 (OMIM: 300451,305100,313500) PREDICTE ( 388) 163 42.0 0.0019 NP_001390 (OMIM: 300451,305100,313500) ectodysplas ( 391) 163 42.0 0.0019 NP_001005612 (OMIM: 300451,305100,313500) ectodysp ( 386) 161 41.6 0.0024 NP_001005609 (OMIM: 300451,305100,313500) ectodysp ( 389) 161 41.6 0.0025 >>NP_003799 (OMIM: 604472) tumor necrosis factor ligand (250 aa) initn: 1684 init1: 1684 opt: 1684 Z-score: 1840.8 bits: 348.1 E(85289): 8.6e-96 Smith-Waterman score: 1684; 99.6% identity (100.0% similar) in 250 aa overlap (1-250:1-250) 10 20 30 40 50 60 pF1KE3 MPASSPFLLAPKGPPGNMGGPVREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MPASSPFLLAPKGPPGNMGGPVREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 EVSRLQGTGGPSQNGEGYPWQSLPEQSSDALEAWESGERSRKRRAVLTQKQKKQHSVLHL :::::::::::::::::::::::::::::::::::.:::::::::::::::::::::::: NP_003 EVSRLQGTGGPSQNGEGYPWQSLPEQSSDALEAWENGERSRKRRAVLTQKQKKQHSVLHL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 VPINATSKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 VPINATSKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 VVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 VVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSP 190 200 210 220 230 240 250 pF1KE3 HGTFLGFVKL :::::::::: NP_003 HGTFLGFVKL 250 >>NP_742085 (OMIM: 604472) tumor necrosis factor ligand (247 aa) initn: 1678 init1: 1661 opt: 1661 Z-score: 1815.8 bits: 343.5 E(85289): 2.1e-94 Smith-Waterman score: 1661; 99.2% identity (100.0% similar) in 247 aa overlap (1-247:1-247) 10 20 30 40 50 60 pF1KE3 MPASSPFLLAPKGPPGNMGGPVREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 MPASSPFLLAPKGPPGNMGGPVREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 EVSRLQGTGGPSQNGEGYPWQSLPEQSSDALEAWESGERSRKRRAVLTQKQKKQHSVLHL :::::::::::::::::::::::::::::::::::.:::::::::::::::::::::::: NP_742 EVSRLQGTGGPSQNGEGYPWQSLPEQSSDALEAWENGERSRKRRAVLTQKQKKQHSVLHL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 VPINATSKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 VPINATSKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 VVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 VVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSP 190 200 210 220 230 240 250 pF1KE3 HGTFLGFVKL ::::::. NP_742 HGTFLGL >>NP_001185553 (OMIM: 604472) tumor necrosis factor liga (205 aa) initn: 928 init1: 928 opt: 928 Z-score: 1019.4 bits: 195.9 E(85289): 4.8e-50 Smith-Waterman score: 1321; 88.0% identity (88.0% similar) in 233 aa overlap (18-250:1-205) 10 20 30 40 50 60 pF1KE3 MPASSPFLLAPKGPPGNMGGPVREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRR ::::::::::::::::::::::::::::::::::::::::::: NP_001 MGGPVREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRR 10 20 30 40 70 80 90 100 110 120 pF1KE3 EVSRLQGTGGPSQNGEGYPWQSLPEQSSDALEAWESGERSRKRRAVLTQKQKKQHSVLHL :::::::::::::::::::::::::: :::::: NP_001 EVSRLQGTGGPSQNGEGYPWQSLPEQ----------------------------HSVLHL 50 60 70 130 140 150 160 170 180 pF1KE3 VPINATSKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VPINATSKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQ 80 90 100 110 120 130 190 200 210 220 230 240 pF1KE3 VVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSP 140 150 160 170 180 190 250 pF1KE3 HGTFLGFVKL :::::::::: NP_001 HGTFLGFVKL 200 >>NP_001185552 (OMIM: 604472) tumor necrosis factor liga (222 aa) initn: 928 init1: 928 opt: 928 Z-score: 1018.9 bits: 195.9 E(85289): 5.1e-50 Smith-Waterman score: 1445; 88.8% identity (88.8% similar) in 250 aa overlap (1-250:1-222) 10 20 30 40 50 60 pF1KE3 MPASSPFLLAPKGPPGNMGGPVREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPASSPFLLAPKGPPGNMGGPVREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 EVSRLQGTGGPSQNGEGYPWQSLPEQSSDALEAWESGERSRKRRAVLTQKQKKQHSVLHL :::::::::::::::::::::::::: :::::: NP_001 EVSRLQGTGGPSQNGEGYPWQSLPEQ----------------------------HSVLHL 70 80 90 130 140 150 160 170 180 pF1KE3 VPINATSKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VPINATSKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQ 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE3 VVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSP 160 170 180 190 200 210 250 pF1KE3 HGTFLGFVKL :::::::::: NP_001 HGTFLGFVKL 220 >>NP_001185551 (OMIM: 604472) tumor necrosis factor liga (223 aa) initn: 926 init1: 926 opt: 926 Z-score: 1016.7 bits: 195.5 E(85289): 6.8e-50 Smith-Waterman score: 1454; 89.2% identity (89.2% similar) in 250 aa overlap (1-250:1-223) 10 20 30 40 50 60 pF1KE3 MPASSPFLLAPKGPPGNMGGPVREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPASSPFLLAPKGPPGNMGGPVREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 EVSRLQGTGGPSQNGEGYPWQSLPEQSSDALEAWESGERSRKRRAVLTQKQKKQHSVLHL :::::::::::::::::::::::::: ::::::: NP_001 EVSRLQGTGGPSQNGEGYPWQSLPEQ---------------------------QHSVLHL 70 80 90 130 140 150 160 170 180 pF1KE3 VPINATSKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VPINATSKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQ 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE3 VVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSP 160 170 180 190 200 210 250 pF1KE3 HGTFLGFVKL :::::::::: NP_001 HGTFLGFVKL 220 >>NP_742084 (OMIM: 604472) tumor necrosis factor ligand (234 aa) initn: 828 init1: 828 opt: 832 Z-score: 914.1 bits: 176.6 E(85289): 3.5e-44 Smith-Waterman score: 1535; 92.8% identity (93.6% similar) in 250 aa overlap (1-250:1-234) 10 20 30 40 50 60 pF1KE3 MPASSPFLLAPKGPPGNMGGPVREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 MPASSPFLLAPKGPPGNMGGPVREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 EVSRLQGTGGPSQNGEGYPWQSLPEQSSDALEAWESGERSRKRRAVLTQKQKKQHSVLHL :::::::::::::::::::::::::::::::::::.:::::::::::::::: NP_742 EVSRLQGTGGPSQNGEGYPWQSLPEQSSDALEAWENGERSRKRRAVLTQKQK-------- 70 80 90 100 110 130 140 150 160 170 180 pF1KE3 VPINATSKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQ .::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 --------NDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQ 120 130 140 150 160 190 200 210 220 230 240 pF1KE3 VVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 VVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSP 170 180 190 200 210 220 250 pF1KE3 HGTFLGFVKL :::::::::: NP_742 HGTFLGFVKL 230 >>NP_006564 (OMIM: 603969) tumor necrosis factor ligand (285 aa) initn: 302 init1: 135 opt: 312 Z-score: 347.1 bits: 71.9 E(85289): 1.4e-12 Smith-Waterman score: 324; 31.8% identity (62.2% similar) in 217 aa overlap (52-250:73-284) 30 40 50 60 70 80 pF1KE3 VREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRREVSRLQGTGGPSQNGEGYPWQ : .: ::: :.. .. :. : : : NP_006 KDGKLLAATLLLALLSCCLTVVSFYQVAALQGDLASLRAELQGHHAEKLPA--GAGAPKA 50 60 70 80 90 100 90 100 110 120 130 pF1KE3 SLPEQS--SDALEAWE--------SGERSRKRRAVLTQKQKKQHSVLHLVPINAT-SKDD .: : . .:. .: :.. ::..::: .. .. :.:. . : . . NP_006 GLEEAPAVTAGLKIFEPPAPGEGNSSQNSRNKRAVQGPEETVTQDCLQLIADSETPTIQK 110 120 130 140 150 160 140 150 160 170 180 pF1KE3 SDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQVVSRE----- .. : : : ...:: .:. . . ....: ...:.:::. : :..::....:. NP_006 GSYTFVPWLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVHVF 170 180 190 200 210 220 190 200 210 220 230 240 pF1KE3 -GQGRQETLFRCIRSMP-SHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSPHGT . ::::::..:: . :. :::::::. .:..:: :.. ::: :...:. : NP_006 GDELSLVTLFRCIQNMPETLPN---NSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVT 230 240 250 260 270 250 pF1KE3 FLGFVKL :.: .:: NP_006 FFGALKLL 280 >>NP_001139117 (OMIM: 603969) tumor necrosis factor liga (266 aa) initn: 319 init1: 135 opt: 285 Z-score: 318.1 bits: 66.5 E(85289): 5.6e-11 Smith-Waterman score: 286; 30.6% identity (58.8% similar) in 216 aa overlap (52-250:73-265) 30 40 50 60 70 80 pF1KE3 VREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRREVSRLQGTGGPSQNGEGYPWQ : .: ::: :.. .. :. : : : NP_001 KDGKLLAATLLLALLSCCLTVVSFYQVAALQGDLASLRAELQGHHAEKLPA--GAGAPKA 50 60 70 80 90 100 90 100 110 120 130 pF1KE3 SLPEQS--SDALEAWE--------SGERSRKRRAVLTQKQKKQHSVLHLVPINATSKDDS .: : . .:. .: :.. ::..::: .. ... .:: NP_001 GLEEAPAVTAGLKIFEPPAPGEGNSSQNSRNKRAVQGPEETGSYT---FVP--------- 110 120 130 140 140 150 160 170 180 pF1KE3 DVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQVVSRE------ : ...:: .:. . . ....: ...:.:::. : :..::....:. NP_001 ------WLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVHVFG 150 160 170 180 190 200 190 200 210 220 230 240 pF1KE3 GQGRQETLFRCIRSMP-SHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSPHGTF . ::::::..:: . :. :::::::. .:..:: :.. ::: :...:. :: NP_001 DELSLVTLFRCIQNMPETLPN---NSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVTF 210 220 230 240 250 250 pF1KE3 LGFVKL .: .:: NP_001 FGALKLL 260 >>XP_006724693 (OMIM: 300451,305100,313500) PREDICTED: e (388 aa) initn: 218 init1: 112 opt: 163 Z-score: 183.0 bits: 42.0 E(85289): 0.0019 Smith-Waterman score: 172; 25.8% identity (54.9% similar) in 182 aa overlap (69-250:215-382) 40 50 60 70 80 90 pF1KE3 LGAVACAMALLTQQTELQSLRREVSRLQGTGGPSQNGEGYPWQSLPEQSSDALEAWESGE : :. : : :. : .. . : ..: XP_006 NGPPGPPGPPGPQGPPGIPGIPGIPGTTVMGPPGPPGPPGP-QGPPGLQGPSGAADKAGT 190 200 210 220 230 240 100 110 120 130 140 150 pF1KE3 RSRKRRAVLTQKQKKQHSVLHLVPINATSKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQ : . .: : : . .: . .: : ... .: . . :. .. ... XP_006 RENQPAVVHLQGQGSAIQVKNGGVLN-------DWSRITMNPKVFK---LHPRSGELEVL 250 260 270 280 290 160 170 180 190 200 210 pF1KE3 DAGVYLLYSQVLFQDVTFTMGQVVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFH :.:..:::: ..:: . .: : .. ...: ::. . ::.::.::: XP_006 VDGTYFIYSQVEVYYINFT--DFASYEVVVDEKPFLQCTRSIETGKTN-YNTCYTAGVCL 300 310 320 330 340 350 220 230 240 250 pF1KE3 LHQGDILSVIIPRARAKLNLSPHGTFLGFVKL :. . ..: . .: ..:.: : ::.: ..: XP_006 LKARQKIAVKMVHADISINMSKHTTFFGAIRLGEAPAS 360 370 380 >>NP_001390 (OMIM: 300451,305100,313500) ectodysplasin-A (391 aa) initn: 218 init1: 112 opt: 163 Z-score: 183.0 bits: 42.0 E(85289): 0.0019 Smith-Waterman score: 174; 25.8% identity (56.6% similar) in 182 aa overlap (69-250:215-385) 40 50 60 70 80 90 pF1KE3 LGAVACAMALLTQQTELQSLRREVSRLQGTGGPSQNGEGYPWQSLPEQSSDALEAWESGE : :. : : :. : .. . : ..: NP_001 NGPPGPPGPPGPQGPPGIPGIPGIPGTTVMGPPGPPGPPGP-QGPPGLQGPSGAADKAGT 190 200 210 220 230 240 100 110 120 130 140 150 pF1KE3 RSRKRRAVLTQKQKKQHSVLHLVPINATSKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQ : . .: : : :... : . .. .: ... .: . . :. .. ... NP_001 RENQPAVVHLQG---QGSAIQ-VKNDLSGGVLNDWSRITMNPKVFK---LHPRSGELEVL 250 260 270 280 290 160 170 180 190 200 210 pF1KE3 DAGVYLLYSQVLFQDVTFTMGQVVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFH :.:..:::: ..:: . .: : .. ...: ::. . ::.::.::: NP_001 VDGTYFIYSQVEVYYINFT--DFASYEVVVDEKPFLQCTRSIETGKTN-YNTCYTAGVCL 300 310 320 330 340 350 220 230 240 250 pF1KE3 LHQGDILSVIIPRARAKLNLSPHGTFLGFVKL :. . ..: . .: ..:.: : ::.: ..: NP_001 LKARQKIAVKMVHADISINMSKHTTFFGAIRLGEAPAS 360 370 380 390 250 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 05:15:39 2016 done: Sun Nov 6 05:15:40 2016 Total Scan time: 7.050 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]