FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2040, 651 aa 1>>>pF1KE2040 651 - 651 aa - 651 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.6099+/-0.000372; mu= 9.3566+/- 0.023 mean_var=133.6106+/-27.837, 0's: 0 Z-trim(117.9): 69 B-trim: 735 in 1/53 Lambda= 0.110957 statistics sampled from 30201 (30270) to 30201 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.702), E-opt: 0.2 (0.355), width: 16 Scan time: 10.620 The best scores are: opt bits E(85289) NP_057250 (OMIM: 603566) E3 SUMO-protein ligase PI ( 651) 4330 704.8 2.5e-202 NP_001307616 (OMIM: 603566) E3 SUMO-protein ligase ( 653) 4291 698.5 1.9e-200 XP_016878177 (OMIM: 603566) PREDICTED: E3 SUMO-pro ( 653) 4291 698.5 1.9e-200 XP_011520429 (OMIM: 603566) PREDICTED: E3 SUMO-pro ( 645) 4287 697.9 3e-200 XP_016878178 (OMIM: 603566) PREDICTED: E3 SUMO-pro ( 644) 4283 697.2 4.6e-200 XP_011520428 (OMIM: 603566) PREDICTED: E3 SUMO-pro ( 660) 4283 697.2 4.7e-200 XP_016878180 (OMIM: 603566) PREDICTED: E3 SUMO-pro ( 642) 4276 696.1 1e-199 XP_016878179 (OMIM: 603566) PREDICTED: E3 SUMO-pro ( 642) 4276 696.1 1e-199 NP_006090 (OMIM: 605987) E3 SUMO-protein ligase PI ( 628) 2303 380.3 1.2e-104 XP_011524561 (OMIM: 603567) PREDICTED: E3 SUMO-pro ( 613) 1853 308.2 5.5e-83 NP_001310976 (OMIM: 603567) E3 SUMO-protein ligase ( 613) 1853 308.2 5.5e-83 XP_016881557 (OMIM: 603567) PREDICTED: E3 SUMO-pro ( 613) 1853 308.2 5.5e-83 XP_011524560 (OMIM: 603567) PREDICTED: E3 SUMO-pro ( 620) 1853 308.2 5.6e-83 XP_005258436 (OMIM: 603567) PREDICTED: E3 SUMO-pro ( 622) 1853 308.2 5.6e-83 XP_005258434 (OMIM: 603567) PREDICTED: E3 SUMO-pro ( 626) 1853 308.2 5.6e-83 XP_006722634 (OMIM: 603567) PREDICTED: E3 SUMO-pro ( 661) 1853 308.3 5.9e-83 XP_016881559 (OMIM: 603567) PREDICTED: E3 SUMO-pro ( 612) 1842 306.5 1.9e-82 NP_001310977 (OMIM: 603567) E3 SUMO-protein ligase ( 612) 1842 306.5 1.9e-82 NP_001310978 (OMIM: 603567) E3 SUMO-protein ligase ( 612) 1842 306.5 1.9e-82 XP_016881558 (OMIM: 603567) PREDICTED: E3 SUMO-pro ( 612) 1842 306.5 1.9e-82 NP_004662 (OMIM: 603567) E3 SUMO-protein ligase PI ( 621) 1842 306.5 1.9e-82 XP_006722635 (OMIM: 603567) PREDICTED: E3 SUMO-pro ( 660) 1842 306.5 2e-82 NP_001310975 (OMIM: 603567) E3 SUMO-protein ligase ( 571) 1836 305.5 3.4e-82 NP_001310983 (OMIM: 603567) E3 SUMO-protein ligase ( 563) 1802 300.1 1.5e-80 NP_001310980 (OMIM: 603567) E3 SUMO-protein ligase ( 563) 1802 300.1 1.5e-80 NP_001310982 (OMIM: 603567) E3 SUMO-protein ligase ( 563) 1802 300.1 1.5e-80 XP_016881561 (OMIM: 603567) PREDICTED: E3 SUMO-pro ( 563) 1802 300.1 1.5e-80 XP_016881560 (OMIM: 603567) PREDICTED: E3 SUMO-pro ( 563) 1802 300.1 1.5e-80 NP_001310981 (OMIM: 603567) E3 SUMO-protein ligase ( 563) 1802 300.1 1.5e-80 NP_775298 (OMIM: 603567) E3 SUMO-protein ligase PI ( 572) 1802 300.1 1.5e-80 XP_006722636 (OMIM: 603567) PREDICTED: E3 SUMO-pro ( 611) 1802 300.1 1.6e-80 NP_001310988 (OMIM: 603567) E3 SUMO-protein ligase ( 498) 1717 286.4 1.7e-76 NP_001310986 (OMIM: 603567) E3 SUMO-protein ligase ( 498) 1717 286.4 1.7e-76 NP_001310984 (OMIM: 603567) E3 SUMO-protein ligase ( 498) 1717 286.4 1.7e-76 NP_001310987 (OMIM: 603567) E3 SUMO-protein ligase ( 507) 1717 286.4 1.7e-76 NP_001310989 (OMIM: 603567) E3 SUMO-protein ligase ( 405) 1413 237.7 6.2e-62 NP_056981 (OMIM: 605989) E3 SUMO-protein ligase PI ( 510) 1217 206.4 2.1e-52 XP_011526362 (OMIM: 605989) PREDICTED: E3 SUMO-pro ( 529) 1217 206.4 2.2e-52 XP_016882357 (OMIM: 605989) PREDICTED: E3 SUMO-pro ( 319) 1012 173.5 1.1e-42 XP_005249927 (OMIM: 611196) PREDICTED: zinc finger ( 903) 323 63.4 4.1e-09 NP_001287888 (OMIM: 611196) zinc finger MIZ domain ( 862) 307 60.8 2.3e-08 XP_005249929 (OMIM: 611196) PREDICTED: zinc finger ( 894) 307 60.8 2.4e-08 NP_777589 (OMIM: 611196) zinc finger MIZ domain-co ( 894) 307 60.8 2.4e-08 XP_011513868 (OMIM: 611196) PREDICTED: zinc finger ( 655) 300 59.7 4e-08 XP_005249928 (OMIM: 611196) PREDICTED: zinc finger ( 897) 300 59.7 5.2e-08 XP_005249924 (OMIM: 611196) PREDICTED: zinc finger ( 929) 300 59.7 5.4e-08 XP_005249925 (OMIM: 611196) PREDICTED: zinc finger ( 929) 300 59.7 5.4e-08 XP_005249923 (OMIM: 611196) PREDICTED: zinc finger ( 929) 300 59.7 5.4e-08 XP_016868163 (OMIM: 611196) PREDICTED: zinc finger ( 929) 300 59.7 5.4e-08 XP_005249930 (OMIM: 611196) PREDICTED: zinc finger ( 888) 284 57.2 3.1e-07 >>NP_057250 (OMIM: 603566) E3 SUMO-protein ligase PIAS1 (651 aa) initn: 4330 init1: 4330 opt: 4330 Z-score: 3753.3 bits: 704.8 E(85289): 2.5e-202 Smith-Waterman score: 4330; 100.0% identity (100.0% similar) in 651 aa overlap (1-651:1-651) 10 20 30 40 50 60 pF1KE2 MADSAELKQMVMSLRVSELQVLLGYAGRNKHGRKHELLTKALHLLKAGCSPAVQMKIKEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 MADSAELKQMVMSLRVSELQVLLGYAGRNKHGRKHELLTKALHLLKAGCSPAVQMKIKEL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 YRRRFPQKIMTPADLSIPNVHSSPMPATLSPSTIPQLTYDGHPASSPLLPVSLLGPKHEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 YRRRFPQKIMTPADLSIPNVHSSPMPATLSPSTIPQLTYDGHPASSPLLPVSLLGPKHEL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 ELPHLTSALHPVHPDIKLQKLPFYDLLDELIKPTSLASDNSQRFRETCFAFALTPQQVQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 ELPHLTSALHPVHPDIKLQKLPFYDLLDELIKPTSLASDNSQRFRETCFAFALTPQQVQQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 ISSSMDISGTKCDFTVQVQLRFCLSETSCPQEDHFPPNLCVKVNTKPCSLPGYLPPTKNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 ISSSMDISGTKCDFTVQVQLRFCLSETSCPQEDHFPPNLCVKVNTKPCSLPGYLPPTKNG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 VEPKRPSRPINITSLVRLSTTVPNTIVVSWTAEIGRNYSMAVYLVKQLSSTVLLQRLRAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 VEPKRPSRPINITSLVRLSTTVPNTIVVSWTAEIGRNYSMAVYLVKQLSSTVLLQRLRAK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 GIRNPDHSRALIKEKLTADPDSEIATTSLRVSLLCPLGKMRLTIPCRALTCSHLQCFDAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 GIRNPDHSRALIKEKLTADPDSEIATTSLRVSLLCPLGKMRLTIPCRALTCSHLQCFDAT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 LYIQMNEKKPTWVCPVCDKKAPYEHLIIDGLFMEILKYCTDCDEIQFKEDGTWAPMRSKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 LYIQMNEKKPTWVCPVCDKKAPYEHLIIDGLFMEILKYCTDCDEIQFKEDGTWAPMRSKK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 EVQEVSASYNGVDGCLSSTLEHQVASHHQSSNKNKKVEVIDLTIDSSSDEEEEEPSAKRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 EVQEVSASYNGVDGCLSSTLEHQVASHHQSSNKNKKVEVIDLTIDSSSDEEEEEPSAKRT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 CPSLSPTSPLNNKGILSLPHQASPVSRTPSLPAVDTSYINTSLIQDYRHPFHMTPMPYDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 CPSLSPTSPLNNKGILSLPHQASPVSRTPSLPAVDTSYINTSLIQDYRHPFHMTPMPYDL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 QGLDFFPFLSGDNQHYNTSLLAAAAAAVSDDQDLLHSSRFFPYTSSQMFLDQLSAGGSTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 QGLDFFPFLSGDNQHYNTSLLAAAAAAVSDDQDLLHSSRFFPYTSSQMFLDQLSAGGSTS 550 560 570 580 590 600 610 620 630 640 650 pF1KE2 LPTTNGSSSGSNSSLVSSNSLRESHSHTVTNRSSTDTASIFGIIPDIISLD ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 LPTTNGSSSGSNSSLVSSNSLRESHSHTVTNRSSTDTASIFGIIPDIISLD 610 620 630 640 650 >>NP_001307616 (OMIM: 603566) E3 SUMO-protein ligase PIA (653 aa) initn: 4290 init1: 4290 opt: 4291 Z-score: 3719.6 bits: 698.5 E(85289): 1.9e-200 Smith-Waterman score: 4291; 99.2% identity (99.5% similar) in 651 aa overlap (1-651:4-653) 10 20 30 40 50 pF1KE2 MADSAELKQMVMSLRVSELQVLLGYAGRNKHGRKHELLTKALHLLKAGCSPAVQMKI . :: .:::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MFTLQDSY-VKQMVMSLRVSELQVLLGYAGRNKHGRKHELLTKALHLLKAGCSPAVQMKI 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 KELYRRRFPQKIMTPADLSIPNVHSSPMPATLSPSTIPQLTYDGHPASSPLLPVSLLGPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KELYRRRFPQKIMTPADLSIPNVHSSPMPATLSPSTIPQLTYDGHPASSPLLPVSLLGPK 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 HELELPHLTSALHPVHPDIKLQKLPFYDLLDELIKPTSLASDNSQRFRETCFAFALTPQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HELELPHLTSALHPVHPDIKLQKLPFYDLLDELIKPTSLASDNSQRFRETCFAFALTPQQ 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE2 VQQISSSMDISGTKCDFTVQVQLRFCLSETSCPQEDHFPPNLCVKVNTKPCSLPGYLPPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VQQISSSMDISGTKCDFTVQVQLRFCLSETSCPQEDHFPPNLCVKVNTKPCSLPGYLPPT 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE2 KNGVEPKRPSRPINITSLVRLSTTVPNTIVVSWTAEIGRNYSMAVYLVKQLSSTVLLQRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KNGVEPKRPSRPINITSLVRLSTTVPNTIVVSWTAEIGRNYSMAVYLVKQLSSTVLLQRL 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE2 RAKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLLCPLGKMRLTIPCRALTCSHLQCF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RAKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLLCPLGKMRLTIPCRALTCSHLQCF 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE2 DATLYIQMNEKKPTWVCPVCDKKAPYEHLIIDGLFMEILKYCTDCDEIQFKEDGTWAPMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DATLYIQMNEKKPTWVCPVCDKKAPYEHLIIDGLFMEILKYCTDCDEIQFKEDGTWAPMR 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE2 SKKEVQEVSASYNGVDGCLSSTLEHQVASHHQSSNKNKKVEVIDLTIDSSSDEEEEEPSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SKKEVQEVSASYNGVDGCLSSTLEHQVASHHQSSNKNKKVEVIDLTIDSSSDEEEEEPSA 420 430 440 450 460 470 480 490 500 510 520 530 pF1KE2 KRTCPSLSPTSPLNNKGILSLPHQASPVSRTPSLPAVDTSYINTSLIQDYRHPFHMTPMP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KRTCPSLSPTSPLNNKGILSLPHQASPVSRTPSLPAVDTSYINTSLIQDYRHPFHMTPMP 480 490 500 510 520 530 540 550 560 570 580 590 pF1KE2 YDLQGLDFFPFLSGDNQHYNTSLLAAAAAAVSDDQDLLHSSRFFPYTSSQMFLDQLSAGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YDLQGLDFFPFLSGDNQHYNTSLLAAAAAAVSDDQDLLHSSRFFPYTSSQMFLDQLSAGG 540 550 560 570 580 590 600 610 620 630 640 650 pF1KE2 STSLPTTNGSSSGSNSSLVSSNSLRESHSHTVTNRSSTDTASIFGIIPDIISLD :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 STSLPTTNGSSSGSNSSLVSSNSLRESHSHTVTNRSSTDTASIFGIIPDIISLD 600 610 620 630 640 650 >>XP_016878177 (OMIM: 603566) PREDICTED: E3 SUMO-protein (653 aa) initn: 4290 init1: 4290 opt: 4291 Z-score: 3719.6 bits: 698.5 E(85289): 1.9e-200 Smith-Waterman score: 4291; 99.2% identity (99.5% similar) in 651 aa overlap (1-651:4-653) 10 20 30 40 50 pF1KE2 MADSAELKQMVMSLRVSELQVLLGYAGRNKHGRKHELLTKALHLLKAGCSPAVQMKI . :: .:::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MFTLQDSY-VKQMVMSLRVSELQVLLGYAGRNKHGRKHELLTKALHLLKAGCSPAVQMKI 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 KELYRRRFPQKIMTPADLSIPNVHSSPMPATLSPSTIPQLTYDGHPASSPLLPVSLLGPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KELYRRRFPQKIMTPADLSIPNVHSSPMPATLSPSTIPQLTYDGHPASSPLLPVSLLGPK 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 HELELPHLTSALHPVHPDIKLQKLPFYDLLDELIKPTSLASDNSQRFRETCFAFALTPQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HELELPHLTSALHPVHPDIKLQKLPFYDLLDELIKPTSLASDNSQRFRETCFAFALTPQQ 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE2 VQQISSSMDISGTKCDFTVQVQLRFCLSETSCPQEDHFPPNLCVKVNTKPCSLPGYLPPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VQQISSSMDISGTKCDFTVQVQLRFCLSETSCPQEDHFPPNLCVKVNTKPCSLPGYLPPT 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE2 KNGVEPKRPSRPINITSLVRLSTTVPNTIVVSWTAEIGRNYSMAVYLVKQLSSTVLLQRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KNGVEPKRPSRPINITSLVRLSTTVPNTIVVSWTAEIGRNYSMAVYLVKQLSSTVLLQRL 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE2 RAKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLLCPLGKMRLTIPCRALTCSHLQCF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RAKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLLCPLGKMRLTIPCRALTCSHLQCF 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE2 DATLYIQMNEKKPTWVCPVCDKKAPYEHLIIDGLFMEILKYCTDCDEIQFKEDGTWAPMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DATLYIQMNEKKPTWVCPVCDKKAPYEHLIIDGLFMEILKYCTDCDEIQFKEDGTWAPMR 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE2 SKKEVQEVSASYNGVDGCLSSTLEHQVASHHQSSNKNKKVEVIDLTIDSSSDEEEEEPSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SKKEVQEVSASYNGVDGCLSSTLEHQVASHHQSSNKNKKVEVIDLTIDSSSDEEEEEPSA 420 430 440 450 460 470 480 490 500 510 520 530 pF1KE2 KRTCPSLSPTSPLNNKGILSLPHQASPVSRTPSLPAVDTSYINTSLIQDYRHPFHMTPMP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KRTCPSLSPTSPLNNKGILSLPHQASPVSRTPSLPAVDTSYINTSLIQDYRHPFHMTPMP 480 490 500 510 520 530 540 550 560 570 580 590 pF1KE2 YDLQGLDFFPFLSGDNQHYNTSLLAAAAAAVSDDQDLLHSSRFFPYTSSQMFLDQLSAGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YDLQGLDFFPFLSGDNQHYNTSLLAAAAAAVSDDQDLLHSSRFFPYTSSQMFLDQLSAGG 540 550 560 570 580 590 600 610 620 630 640 650 pF1KE2 STSLPTTNGSSSGSNSSLVSSNSLRESHSHTVTNRSSTDTASIFGIIPDIISLD :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 STSLPTTNGSSSGSNSSLVSSNSLRESHSHTVTNRSSTDTASIFGIIPDIISLD 600 610 620 630 640 650 >>XP_011520429 (OMIM: 603566) PREDICTED: E3 SUMO-protein (645 aa) initn: 4287 init1: 4287 opt: 4287 Z-score: 3716.2 bits: 697.9 E(85289): 3e-200 Smith-Waterman score: 4287; 99.7% identity (100.0% similar) in 645 aa overlap (7-651:1-645) 10 20 30 40 50 60 pF1KE2 MADSAELKQMVMSLRVSELQVLLGYAGRNKHGRKHELLTKALHLLKAGCSPAVQMKIKEL ..:::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MEQMVMSLRVSELQVLLGYAGRNKHGRKHELLTKALHLLKAGCSPAVQMKIKEL 10 20 30 40 50 70 80 90 100 110 120 pF1KE2 YRRRFPQKIMTPADLSIPNVHSSPMPATLSPSTIPQLTYDGHPASSPLLPVSLLGPKHEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YRRRFPQKIMTPADLSIPNVHSSPMPATLSPSTIPQLTYDGHPASSPLLPVSLLGPKHEL 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE2 ELPHLTSALHPVHPDIKLQKLPFYDLLDELIKPTSLASDNSQRFRETCFAFALTPQQVQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ELPHLTSALHPVHPDIKLQKLPFYDLLDELIKPTSLASDNSQRFRETCFAFALTPQQVQQ 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE2 ISSSMDISGTKCDFTVQVQLRFCLSETSCPQEDHFPPNLCVKVNTKPCSLPGYLPPTKNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ISSSMDISGTKCDFTVQVQLRFCLSETSCPQEDHFPPNLCVKVNTKPCSLPGYLPPTKNG 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE2 VEPKRPSRPINITSLVRLSTTVPNTIVVSWTAEIGRNYSMAVYLVKQLSSTVLLQRLRAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VEPKRPSRPINITSLVRLSTTVPNTIVVSWTAEIGRNYSMAVYLVKQLSSTVLLQRLRAK 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE2 GIRNPDHSRALIKEKLTADPDSEIATTSLRVSLLCPLGKMRLTIPCRALTCSHLQCFDAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GIRNPDHSRALIKEKLTADPDSEIATTSLRVSLLCPLGKMRLTIPCRALTCSHLQCFDAT 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE2 LYIQMNEKKPTWVCPVCDKKAPYEHLIIDGLFMEILKYCTDCDEIQFKEDGTWAPMRSKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LYIQMNEKKPTWVCPVCDKKAPYEHLIIDGLFMEILKYCTDCDEIQFKEDGTWAPMRSKK 360 370 380 390 400 410 430 440 450 460 470 480 pF1KE2 EVQEVSASYNGVDGCLSSTLEHQVASHHQSSNKNKKVEVIDLTIDSSSDEEEEEPSAKRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EVQEVSASYNGVDGCLSSTLEHQVASHHQSSNKNKKVEVIDLTIDSSSDEEEEEPSAKRT 420 430 440 450 460 470 490 500 510 520 530 540 pF1KE2 CPSLSPTSPLNNKGILSLPHQASPVSRTPSLPAVDTSYINTSLIQDYRHPFHMTPMPYDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CPSLSPTSPLNNKGILSLPHQASPVSRTPSLPAVDTSYINTSLIQDYRHPFHMTPMPYDL 480 490 500 510 520 530 550 560 570 580 590 600 pF1KE2 QGLDFFPFLSGDNQHYNTSLLAAAAAAVSDDQDLLHSSRFFPYTSSQMFLDQLSAGGSTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QGLDFFPFLSGDNQHYNTSLLAAAAAAVSDDQDLLHSSRFFPYTSSQMFLDQLSAGGSTS 540 550 560 570 580 590 610 620 630 640 650 pF1KE2 LPTTNGSSSGSNSSLVSSNSLRESHSHTVTNRSSTDTASIFGIIPDIISLD ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LPTTNGSSSGSNSSLVSSNSLRESHSHTVTNRSSTDTASIFGIIPDIISLD 600 610 620 630 640 >>XP_016878178 (OMIM: 603566) PREDICTED: E3 SUMO-protein (644 aa) initn: 4283 init1: 4283 opt: 4283 Z-score: 3712.7 bits: 697.2 E(85289): 4.6e-200 Smith-Waterman score: 4283; 100.0% identity (100.0% similar) in 643 aa overlap (9-651:2-644) 10 20 30 40 50 60 pF1KE2 MADSAELKQMVMSLRVSELQVLLGYAGRNKHGRKHELLTKALHLLKAGCSPAVQMKIKEL :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MQMVMSLRVSELQVLLGYAGRNKHGRKHELLTKALHLLKAGCSPAVQMKIKEL 10 20 30 40 50 70 80 90 100 110 120 pF1KE2 YRRRFPQKIMTPADLSIPNVHSSPMPATLSPSTIPQLTYDGHPASSPLLPVSLLGPKHEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YRRRFPQKIMTPADLSIPNVHSSPMPATLSPSTIPQLTYDGHPASSPLLPVSLLGPKHEL 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE2 ELPHLTSALHPVHPDIKLQKLPFYDLLDELIKPTSLASDNSQRFRETCFAFALTPQQVQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELPHLTSALHPVHPDIKLQKLPFYDLLDELIKPTSLASDNSQRFRETCFAFALTPQQVQQ 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE2 ISSSMDISGTKCDFTVQVQLRFCLSETSCPQEDHFPPNLCVKVNTKPCSLPGYLPPTKNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ISSSMDISGTKCDFTVQVQLRFCLSETSCPQEDHFPPNLCVKVNTKPCSLPGYLPPTKNG 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE2 VEPKRPSRPINITSLVRLSTTVPNTIVVSWTAEIGRNYSMAVYLVKQLSSTVLLQRLRAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VEPKRPSRPINITSLVRLSTTVPNTIVVSWTAEIGRNYSMAVYLVKQLSSTVLLQRLRAK 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE2 GIRNPDHSRALIKEKLTADPDSEIATTSLRVSLLCPLGKMRLTIPCRALTCSHLQCFDAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GIRNPDHSRALIKEKLTADPDSEIATTSLRVSLLCPLGKMRLTIPCRALTCSHLQCFDAT 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE2 LYIQMNEKKPTWVCPVCDKKAPYEHLIIDGLFMEILKYCTDCDEIQFKEDGTWAPMRSKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LYIQMNEKKPTWVCPVCDKKAPYEHLIIDGLFMEILKYCTDCDEIQFKEDGTWAPMRSKK 360 370 380 390 400 410 430 440 450 460 470 480 pF1KE2 EVQEVSASYNGVDGCLSSTLEHQVASHHQSSNKNKKVEVIDLTIDSSSDEEEEEPSAKRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EVQEVSASYNGVDGCLSSTLEHQVASHHQSSNKNKKVEVIDLTIDSSSDEEEEEPSAKRT 420 430 440 450 460 470 490 500 510 520 530 540 pF1KE2 CPSLSPTSPLNNKGILSLPHQASPVSRTPSLPAVDTSYINTSLIQDYRHPFHMTPMPYDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CPSLSPTSPLNNKGILSLPHQASPVSRTPSLPAVDTSYINTSLIQDYRHPFHMTPMPYDL 480 490 500 510 520 530 550 560 570 580 590 600 pF1KE2 QGLDFFPFLSGDNQHYNTSLLAAAAAAVSDDQDLLHSSRFFPYTSSQMFLDQLSAGGSTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QGLDFFPFLSGDNQHYNTSLLAAAAAAVSDDQDLLHSSRFFPYTSSQMFLDQLSAGGSTS 540 550 560 570 580 590 610 620 630 640 650 pF1KE2 LPTTNGSSSGSNSSLVSSNSLRESHSHTVTNRSSTDTASIFGIIPDIISLD ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPTTNGSSSGSNSSLVSSNSLRESHSHTVTNRSSTDTASIFGIIPDIISLD 600 610 620 630 640 >>XP_011520428 (OMIM: 603566) PREDICTED: E3 SUMO-protein (660 aa) initn: 4283 init1: 4283 opt: 4283 Z-score: 3712.6 bits: 697.2 E(85289): 4.7e-200 Smith-Waterman score: 4283; 100.0% identity (100.0% similar) in 643 aa overlap (9-651:18-660) 10 20 30 40 50 pF1KE2 MADSAELKQMVMSLRVSELQVLLGYAGRNKHGRKHELLTKALHLLKAGCSP ::::::::::::::::::::::::::::::::::::::::::: XP_011 MKLNGKRNHNYKSYYECQMVMSLRVSELQVLLGYAGRNKHGRKHELLTKALHLLKAGCSP 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 AVQMKIKELYRRRFPQKIMTPADLSIPNVHSSPMPATLSPSTIPQLTYDGHPASSPLLPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AVQMKIKELYRRRFPQKIMTPADLSIPNVHSSPMPATLSPSTIPQLTYDGHPASSPLLPV 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 SLLGPKHELELPHLTSALHPVHPDIKLQKLPFYDLLDELIKPTSLASDNSQRFRETCFAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLLGPKHELELPHLTSALHPVHPDIKLQKLPFYDLLDELIKPTSLASDNSQRFRETCFAF 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE2 ALTPQQVQQISSSMDISGTKCDFTVQVQLRFCLSETSCPQEDHFPPNLCVKVNTKPCSLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALTPQQVQQISSSMDISGTKCDFTVQVQLRFCLSETSCPQEDHFPPNLCVKVNTKPCSLP 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE2 GYLPPTKNGVEPKRPSRPINITSLVRLSTTVPNTIVVSWTAEIGRNYSMAVYLVKQLSST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GYLPPTKNGVEPKRPSRPINITSLVRLSTTVPNTIVVSWTAEIGRNYSMAVYLVKQLSST 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE2 VLLQRLRAKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLLCPLGKMRLTIPCRALTC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLLQRLRAKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLLCPLGKMRLTIPCRALTC 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE2 SHLQCFDATLYIQMNEKKPTWVCPVCDKKAPYEHLIIDGLFMEILKYCTDCDEIQFKEDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SHLQCFDATLYIQMNEKKPTWVCPVCDKKAPYEHLIIDGLFMEILKYCTDCDEIQFKEDG 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE2 TWAPMRSKKEVQEVSASYNGVDGCLSSTLEHQVASHHQSSNKNKKVEVIDLTIDSSSDEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TWAPMRSKKEVQEVSASYNGVDGCLSSTLEHQVASHHQSSNKNKKVEVIDLTIDSSSDEE 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE2 EEEPSAKRTCPSLSPTSPLNNKGILSLPHQASPVSRTPSLPAVDTSYINTSLIQDYRHPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EEEPSAKRTCPSLSPTSPLNNKGILSLPHQASPVSRTPSLPAVDTSYINTSLIQDYRHPF 490 500 510 520 530 540 540 550 560 570 580 590 pF1KE2 HMTPMPYDLQGLDFFPFLSGDNQHYNTSLLAAAAAAVSDDQDLLHSSRFFPYTSSQMFLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HMTPMPYDLQGLDFFPFLSGDNQHYNTSLLAAAAAAVSDDQDLLHSSRFFPYTSSQMFLD 550 560 570 580 590 600 600 610 620 630 640 650 pF1KE2 QLSAGGSTSLPTTNGSSSGSNSSLVSSNSLRESHSHTVTNRSSTDTASIFGIIPDIISLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QLSAGGSTSLPTTNGSSSGSNSSLVSSNSLRESHSHTVTNRSSTDTASIFGIIPDIISLD 610 620 630 640 650 660 >>XP_016878180 (OMIM: 603566) PREDICTED: E3 SUMO-protein (642 aa) initn: 4276 init1: 4276 opt: 4276 Z-score: 3706.7 bits: 696.1 E(85289): 1e-199 Smith-Waterman score: 4276; 100.0% identity (100.0% similar) in 642 aa overlap (10-651:1-642) 10 20 30 40 50 60 pF1KE2 MADSAELKQMVMSLRVSELQVLLGYAGRNKHGRKHELLTKALHLLKAGCSPAVQMKIKEL ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MVMSLRVSELQVLLGYAGRNKHGRKHELLTKALHLLKAGCSPAVQMKIKEL 10 20 30 40 50 70 80 90 100 110 120 pF1KE2 YRRRFPQKIMTPADLSIPNVHSSPMPATLSPSTIPQLTYDGHPASSPLLPVSLLGPKHEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YRRRFPQKIMTPADLSIPNVHSSPMPATLSPSTIPQLTYDGHPASSPLLPVSLLGPKHEL 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE2 ELPHLTSALHPVHPDIKLQKLPFYDLLDELIKPTSLASDNSQRFRETCFAFALTPQQVQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELPHLTSALHPVHPDIKLQKLPFYDLLDELIKPTSLASDNSQRFRETCFAFALTPQQVQQ 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE2 ISSSMDISGTKCDFTVQVQLRFCLSETSCPQEDHFPPNLCVKVNTKPCSLPGYLPPTKNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ISSSMDISGTKCDFTVQVQLRFCLSETSCPQEDHFPPNLCVKVNTKPCSLPGYLPPTKNG 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE2 VEPKRPSRPINITSLVRLSTTVPNTIVVSWTAEIGRNYSMAVYLVKQLSSTVLLQRLRAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VEPKRPSRPINITSLVRLSTTVPNTIVVSWTAEIGRNYSMAVYLVKQLSSTVLLQRLRAK 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE2 GIRNPDHSRALIKEKLTADPDSEIATTSLRVSLLCPLGKMRLTIPCRALTCSHLQCFDAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GIRNPDHSRALIKEKLTADPDSEIATTSLRVSLLCPLGKMRLTIPCRALTCSHLQCFDAT 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE2 LYIQMNEKKPTWVCPVCDKKAPYEHLIIDGLFMEILKYCTDCDEIQFKEDGTWAPMRSKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LYIQMNEKKPTWVCPVCDKKAPYEHLIIDGLFMEILKYCTDCDEIQFKEDGTWAPMRSKK 360 370 380 390 400 410 430 440 450 460 470 480 pF1KE2 EVQEVSASYNGVDGCLSSTLEHQVASHHQSSNKNKKVEVIDLTIDSSSDEEEEEPSAKRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EVQEVSASYNGVDGCLSSTLEHQVASHHQSSNKNKKVEVIDLTIDSSSDEEEEEPSAKRT 420 430 440 450 460 470 490 500 510 520 530 540 pF1KE2 CPSLSPTSPLNNKGILSLPHQASPVSRTPSLPAVDTSYINTSLIQDYRHPFHMTPMPYDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CPSLSPTSPLNNKGILSLPHQASPVSRTPSLPAVDTSYINTSLIQDYRHPFHMTPMPYDL 480 490 500 510 520 530 550 560 570 580 590 600 pF1KE2 QGLDFFPFLSGDNQHYNTSLLAAAAAAVSDDQDLLHSSRFFPYTSSQMFLDQLSAGGSTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QGLDFFPFLSGDNQHYNTSLLAAAAAAVSDDQDLLHSSRFFPYTSSQMFLDQLSAGGSTS 540 550 560 570 580 590 610 620 630 640 650 pF1KE2 LPTTNGSSSGSNSSLVSSNSLRESHSHTVTNRSSTDTASIFGIIPDIISLD ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPTTNGSSSGSNSSLVSSNSLRESHSHTVTNRSSTDTASIFGIIPDIISLD 600 610 620 630 640 >>XP_016878179 (OMIM: 603566) PREDICTED: E3 SUMO-protein (642 aa) initn: 4276 init1: 4276 opt: 4276 Z-score: 3706.7 bits: 696.1 E(85289): 1e-199 Smith-Waterman score: 4276; 100.0% identity (100.0% similar) in 642 aa overlap (10-651:1-642) 10 20 30 40 50 60 pF1KE2 MADSAELKQMVMSLRVSELQVLLGYAGRNKHGRKHELLTKALHLLKAGCSPAVQMKIKEL ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MVMSLRVSELQVLLGYAGRNKHGRKHELLTKALHLLKAGCSPAVQMKIKEL 10 20 30 40 50 70 80 90 100 110 120 pF1KE2 YRRRFPQKIMTPADLSIPNVHSSPMPATLSPSTIPQLTYDGHPASSPLLPVSLLGPKHEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YRRRFPQKIMTPADLSIPNVHSSPMPATLSPSTIPQLTYDGHPASSPLLPVSLLGPKHEL 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE2 ELPHLTSALHPVHPDIKLQKLPFYDLLDELIKPTSLASDNSQRFRETCFAFALTPQQVQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELPHLTSALHPVHPDIKLQKLPFYDLLDELIKPTSLASDNSQRFRETCFAFALTPQQVQQ 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE2 ISSSMDISGTKCDFTVQVQLRFCLSETSCPQEDHFPPNLCVKVNTKPCSLPGYLPPTKNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ISSSMDISGTKCDFTVQVQLRFCLSETSCPQEDHFPPNLCVKVNTKPCSLPGYLPPTKNG 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE2 VEPKRPSRPINITSLVRLSTTVPNTIVVSWTAEIGRNYSMAVYLVKQLSSTVLLQRLRAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VEPKRPSRPINITSLVRLSTTVPNTIVVSWTAEIGRNYSMAVYLVKQLSSTVLLQRLRAK 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE2 GIRNPDHSRALIKEKLTADPDSEIATTSLRVSLLCPLGKMRLTIPCRALTCSHLQCFDAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GIRNPDHSRALIKEKLTADPDSEIATTSLRVSLLCPLGKMRLTIPCRALTCSHLQCFDAT 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE2 LYIQMNEKKPTWVCPVCDKKAPYEHLIIDGLFMEILKYCTDCDEIQFKEDGTWAPMRSKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LYIQMNEKKPTWVCPVCDKKAPYEHLIIDGLFMEILKYCTDCDEIQFKEDGTWAPMRSKK 360 370 380 390 400 410 430 440 450 460 470 480 pF1KE2 EVQEVSASYNGVDGCLSSTLEHQVASHHQSSNKNKKVEVIDLTIDSSSDEEEEEPSAKRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EVQEVSASYNGVDGCLSSTLEHQVASHHQSSNKNKKVEVIDLTIDSSSDEEEEEPSAKRT 420 430 440 450 460 470 490 500 510 520 530 540 pF1KE2 CPSLSPTSPLNNKGILSLPHQASPVSRTPSLPAVDTSYINTSLIQDYRHPFHMTPMPYDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CPSLSPTSPLNNKGILSLPHQASPVSRTPSLPAVDTSYINTSLIQDYRHPFHMTPMPYDL 480 490 500 510 520 530 550 560 570 580 590 600 pF1KE2 QGLDFFPFLSGDNQHYNTSLLAAAAAAVSDDQDLLHSSRFFPYTSSQMFLDQLSAGGSTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QGLDFFPFLSGDNQHYNTSLLAAAAAAVSDDQDLLHSSRFFPYTSSQMFLDQLSAGGSTS 540 550 560 570 580 590 610 620 630 640 650 pF1KE2 LPTTNGSSSGSNSSLVSSNSLRESHSHTVTNRSSTDTASIFGIIPDIISLD ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPTTNGSSSGSNSSLVSSNSLRESHSHTVTNRSSTDTASIFGIIPDIISLD 600 610 620 630 640 >>NP_006090 (OMIM: 605987) E3 SUMO-protein ligase PIAS3 (628 aa) initn: 1958 init1: 1388 opt: 2303 Z-score: 2000.0 bits: 380.3 E(85289): 1.2e-104 Smith-Waterman score: 2375; 57.9% identity (78.4% similar) in 663 aa overlap (1-651:1-628) 10 20 30 40 50 60 pF1KE2 MADSAELKQMVMSLRVSELQVLLGYAGRNKHGRKHELLTKALHLLKAGCSPAVQMKIKEL ::. .:::.::::.::::::::::.::::: :::::::.:::::::..:.:.:::::::: NP_006 MAELGELKHMVMSFRVSELQVLLGFAGRNKSGRKHELLAKALHLLKSSCAPSVQMKIKEL 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 YRRRFPQKIMTPADLSIPNVH--SSPM--PATLSPSTIPQLTYDGHPASSPLLPVSLLGP ::::::.: . :.:::. .. .::. :. :.: :: : . : : .:::: NP_006 YRRRFPRKTLGPSDLSLLSLPPGTSPVGSPGPLAP--IP-------P--TLLAPGTLLGP 70 80 90 100 120 130 140 150 160 170 pF1KE2 KHELEL-PHLTSALHPVHPDIKLQKLPFYDLLDELIKPTSLASDNSQRFRETCFAFALTP :.:... : : .:::::. .. ::::.. :::.::.::: .::::.:. :.::::: NP_006 KREVDMHPPLP---QPVHPDVTMKPLPFYEVYGELIRPTTLASTSSQRFEEAHFTFALTP 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE2 QQVQQISSSMDI-SGTKCDFTVQVQLRFCLSETSCPQEDHFPPNLCVKVNTKPCSLPGYL :::::: .: .. :.:::.:.:::::::: ::::::::.::::: :::: : : ::::: NP_006 QQVQQILTSREVLPGAKCDYTIQVQLRFCLCETSCPQEDYFPPNLFVKVNGKLCPLPGYL 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE2 PPTKNGVEPKRPSRPINITSLVRLSTTVPNTIVVSWTAEIGRNYSMAVYLVKQLSSTVLL ::::::.:::::::::::: :.:::.::::::::.:..:.:::::..::::.::.. .:: NP_006 PPTKNGAEPKRPSRPINITPLARLSATVPNTIVVNWSSEFGRNYSLSVYLVRQLTAGTLL 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE2 QRLRAKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLLCPLGKMRLTIPCRALTCSHL :.:::::::::::::::::::::::::::.:::::::::.:::::::::.:::::::.:: NP_006 QKLRAKGIRNPDHSRALIKEKLTADPDSEVATTSLRVSLMCPLGKMRLTVPCRALTCAHL 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE2 QCFDATLYIQMNEKKPTWVCPVCDKKAPYEHLIIDGLFMEILKYCTDCDEIQFKEDGTWA : :::.::.:::::::::.::::::::::: :::::::::::. :.::::::: :::.: NP_006 QSFDAALYLQMNEKKPTWTCPVCDKKAPYESLIIDGLFMEILSSCSDCDEIQFMEDGSWC 350 360 370 380 390 400 420 430 440 450 460 470 pF1KE2 PMRSKKEVQEVSASYN-GVDGCLSSTLEHQVASHHQSSNKNKKVEVIDLTIDSSSDEEEE ::. :::..:: . :.:: :... .. . :...::::::::::.::::::. NP_006 PMKPKKEASEVCPPPGYGLDG-----LQYSPVQGGDPSENKKKVEVIDLTIESSSDEEDL 410 420 430 440 450 460 480 490 500 510 520 530 pF1KE2 EPSAKRTCPSLSPTSPL--NNKGILSLPHQASPVSRTPSLPAVDTSYINTSLIQDYRHPF :. :. : : . : ..::.:. :: : : :.:.. .. ..... ...: : NP_006 PPT-KKHCSVTSAAIPALPGSKGVLTSGHQPSSVLRSPAMGTLGGDFLSSLPLHEYPPAF 470 480 490 500 510 520 540 550 560 570 580 590 pF1KE2 HMTPMPYDLQGLDFFPFLSGDNQHYNTSLLAAAAAAVSDDQDLLHSSRFFPYTSS-QMFL :. :.::::.: ::. ..:::. :.... :.:: : ..:: : .. . :: NP_006 ---PLGADIQGLDLFSFLQTESQHYGPSVITSL-----DEQDAL--GHFFQYRGTPSHFL 530 540 550 560 570 600 610 620 630 640 pF1KE2 DQLSAG-GSTSLPTTNGSSSGSNSSLVS-SNSLRESHSHTVTNRSSTDTASIFGIIPDII :. ::. .: . : ::.:. ...:::.:. . . :. : ::: NP_006 GPLAPTLGSSHCSATPAPPPGRVSSIVAPGGALREGHGGPLPS-----GPSLTGCRSDII 580 590 600 610 620 650 pF1KE2 SLD ::: NP_006 SLD >>XP_011524561 (OMIM: 603567) PREDICTED: E3 SUMO-protein (613 aa) initn: 2120 init1: 1304 opt: 1853 Z-score: 1610.8 bits: 308.2 E(85289): 5.5e-83 Smith-Waterman score: 2175; 55.5% identity (73.3% similar) in 656 aa overlap (10-651:1-613) 10 20 30 40 50 60 pF1KE2 MADSAELKQMVMSLRVSELQVLLGYAGRNKHGRKHELLTKALHLLKAGCSPAVQMKIKEL :: :.::::::::::.::::: ::::.:: .::::::.:::::::.::.:: XP_011 MVSSFRVSELQVLLGFAGRNKSGRKHDLLMRALHLLKSGCSPAVQIKIREL 10 20 30 40 50 70 80 90 100 110 pF1KE2 YRRRFPQKIMTPADLSIPNVH-------SSPMPATLSPS---TIPQLTYDGHPASSPLLP ::::.:. . .::: . :::. :. . ..:. . : :::. XP_011 YRRRYPRTLEGLSDLSTIKSSVFSLDGGSSPVEPDLAVAGIHSLPSTSVTPHSPSSPVGS 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 VSLLGPKHELELPHLTSALHPVHPDIKLQKLPFYDLLDELIKPTSLASDNSQRFRETCFA : : : .:. . . . :::::..:..:::::.:: :::::::.... :::.: : XP_011 VLLQDTKPTFEMQQPSPPIPPVHPDVQLKNLPFYDVLDVLIKPTSLVQSSIQRFQEKFFI 120 130 140 150 160 170 180 190 200 210 220 pF1KE2 FALTPQQVQQISSSMD-ISGTKCDFTVQVQLRFCLSETSCPQEDHFPPNLCVKVNTKPCS ::::::::..: : : . : . :.:::::::.::.::::::::..: .::.::: : XP_011 FALTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQEDNYPNSLCIKVNGKLFP 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE2 LPGYLPPTKNGVEPKRPSRPINITSLVRLSTTVPNTIVVSWTAEIGRNYSMAVYLVKQLS :::: :: :::.: :::.::.:::::::::..::: : .::..:::.::::.::::.::. XP_011 LPGYAPPPKNGIEQKRPGRPLNITSLVRLSSAVPNQISISWASEIGKNYSMSVYLVRQLT 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE2 STVLLQRLRAKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLLCPLGKMRLTIPCRAL :..:::::. ::::::::::::::::::::::::::::::::::.::::::::::::::. XP_011 SAMLLQRLKMKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLMCPLGKMRLTIPCRAV 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE2 TCSHLQCFDATLYIQMNEKKPTWVCPVCDKKAPYEHLIIDGLFMEILKYCTDCDEIQFKE ::.:::::::.::.:::::::::.:::::::: :: ::.::::::::. :.: :::.:.: XP_011 TCTHLQCFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEILNDCSDVDEIKFQE 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE2 DGTWAPMRSKKEVQEVSASYNGVDGCLSSTLEHQVASHHQSSNKNKKVEVIDLTIDSSSD ::.: ::: :::...:: : . ::.: . . : ..:::.::::::.:::: XP_011 DGSWCPMRPKKEAMKVS-SQPCTKIESSSVLSKPCSVTVASEASKKKVDVIDLTIESSSD 420 430 440 450 460 470 470 480 490 500 510 520 pF1KE2 EEEEEPSAKRTCPSLSPTSPLNNKGILSLPHQASPVSRTPSLPAVDTSYINTSLIQDYRH :::. : ::: : .: :. .::.: .: : : :.::. .:: . : :: :: XP_011 EEEDPP-AKRKCIFMSETQSSPTKGVLM--YQPSSV-RVPSVTSVDPAAIPPSLT-DYSV 480 490 500 510 520 530 540 550 560 570 580 pF1KE2 PFHMTP---MPYDLQGLDFFPFLSGDNQHYNTSLLAAAAAAVSDDQDLLHSSRFFPYTSS ::: :: : :: ::::. .. : :.: : XP_011 PFHHTPISSMSSDLPGLDFLSLIPVDPQQYCP-----------------------P---- 530 540 550 590 600 610 620 630 640 pF1KE2 QMFLDQLSAGGSTSLPTTNGSSSGSNSSLVSSNSLRESHSHTVTNRSSTDTASIFGIIPD ::::.:.. ..: ... .:: .:. :::.: : :.. ..:. .:. ::: XP_011 -MFLDSLTSPLTASSTSVTTTSSHESSTHVSSSSSR-SETGVITSSGSN--------IPD 560 570 580 590 600 650 pF1KE2 IISLD ::::: XP_011 IISLD 610 651 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 10:40:43 2016 done: Sun Nov 6 10:40:45 2016 Total Scan time: 10.620 Total Display time: 0.160 Function used was FASTA [36.3.4 Apr, 2011]