FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5678, 471 aa 1>>>pF1KE5678 471 - 471 aa - 471 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 12.6813+/-0.00143; mu= -21.1017+/- 0.081 mean_var=392.2285+/-90.361, 0's: 0 Z-trim(105.4): 326 B-trim: 0 in 0/53 Lambda= 0.064760 statistics sampled from 8078 (8410) to 8078 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.624), E-opt: 0.2 (0.258), width: 16 Scan time: 2.410 The best scores are: opt bits E(32554) CCDS44976.1 MAPKAPK5 gene_id:8550|Hs108|chr12 ( 471) 3137 308.3 1.1e-83 CCDS44975.1 MAPKAPK5 gene_id:8550|Hs108|chr12 ( 473) 3123 307.0 2.8e-83 CCDS12080.1 MKNK2 gene_id:2872|Hs108|chr19 ( 465) 545 66.1 8.8e-11 >>CCDS44976.1 MAPKAPK5 gene_id:8550|Hs108|chr12 (471 aa) initn: 3137 init1: 3137 opt: 3137 Z-score: 1615.8 bits: 308.3 E(32554): 1.1e-83 Smith-Waterman score: 3137; 100.0% identity (100.0% similar) in 471 aa overlap (1-471:1-471) 10 20 30 40 50 60 pF1KE5 MSEESDMDKAIKETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 MSEESDMDKAIKETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKAR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 NEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 NEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 TEKQASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 TEKQASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 MTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 MTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 FYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 FYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 HPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 HPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPIL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE5 RKRKLLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAGENEDEKLNEVMQEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 RKRKLLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAGENEDEKLNEVMQEA 370 380 390 400 410 420 430 440 450 460 470 pF1KE5 WKYNRECKLLRDTLQSFSWNGRGFTDKVDRLKLAEIVKQVIEEQTTSHESQ ::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 WKYNRECKLLRDTLQSFSWNGRGFTDKVDRLKLAEIVKQVIEEQTTSHESQ 430 440 450 460 470 >>CCDS44975.1 MAPKAPK5 gene_id:8550|Hs108|chr12 (473 aa) initn: 2813 init1: 2723 opt: 3123 Z-score: 1608.7 bits: 307.0 E(32554): 2.8e-83 Smith-Waterman score: 3123; 99.6% identity (99.6% similar) in 473 aa overlap (1-471:1-473) 10 20 30 40 50 60 pF1KE5 MSEESDMDKAIKETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 MSEESDMDKAIKETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKAR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 NEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 NEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 TEKQASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 TEKQASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 MTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 MTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 FYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 FYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 HPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 HPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPIL 310 320 330 340 350 360 370 380 390 400 410 pF1KE5 RKRKLLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAG--ENEDEKLNEVMQ :::::::::::::::::::::::::::::::::::::::::::::: :::::::::::: CCDS44 RKRKLLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAGKGENEDEKLNEVMQ 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE5 EAWKYNRECKLLRDTLQSFSWNGRGFTDKVDRLKLAEIVKQVIEEQTTSHESQ ::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 EAWKYNRECKLLRDTLQSFSWNGRGFTDKVDRLKLAEIVKQVIEEQTTSHESQ 430 440 450 460 470 >>CCDS12080.1 MKNK2 gene_id:2872|Hs108|chr19 (465 aa) initn: 539 init1: 226 opt: 545 Z-score: 307.1 bits: 66.1 E(32554): 8.8e-11 Smith-Waterman score: 603; 34.2% identity (64.0% similar) in 339 aa overlap (28-341:90-404) 10 20 30 40 50 pF1KE5 MSEESDMDKAIKETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRP :: : . :..:.. :....:.::. .: CCDS12 KKRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQP 60 70 80 90 100 110 60 70 80 90 100 110 pF1KE5 ---KAR--NEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFH ..: ::.. ..: : :....:: : . . :. .:.: :.:: .. CCDS12 GHIRSRVFREVEMLYQCQGHRNVLELIEFFEE----------EDRFYLVFEKMRGGSILS 120 130 140 150 160 120 130 140 150 160 170 pF1KE5 RISQHRHFTEKQASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGF .: ..:::.: .:: :....: :: : .::::::::::.: . . .:::.::: . CCDS12 HIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDL 170 180 190 200 210 220 180 190 200 210 220 pF1KE5 AK----------IDQGDLMTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSC .. :. .:.:: . :.::.:.:: .:...: :.: : CCDS12 GSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAF----SEEASI---------YDKRC 230 240 250 260 270 230 240 250 260 270 pF1KE5 DLWSLGVIIYVMLCGYPPFYSKHHS-------RTIP--KDMR-RKIMTGSFEFPEEEWSQ ::::::::.:..: ::::: .. : .. : ..: ..:. :..:::...:.. CCDS12 DLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAH 280 290 300 310 320 330 280 290 300 310 320 330 pF1KE5 ISEMAKDVVRKLLKVKPEERLTIEGVLDHPWLNSTEALDNVLPSAQLMMDKAVVAGIQQA :: :::.. ::: ..::. ::.:::... : .:.::. .... .. . . . CCDS12 ISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGC-APENTLPTPMVLQRNSCAKDLTSF 340 350 360 370 380 390 340 350 360 370 380 390 pF1KE5 HAEQLANMRIQDLKVSLKPLHSVNNPILRKRKLLGTKPKDSVYIHDHENGAEDSNVALEK :: .: : CCDS12 AAEAIAMNRQLAQHDEDLAEEEAAGQGQPVLVRATSRCLQLSPPSQSKLAQRRQRASLSS 400 410 420 430 440 450 471 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 05:46:55 2016 done: Tue Nov 8 05:46:56 2016 Total Scan time: 2.410 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]