FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE9510, 479 aa 1>>>pF1KE9510 479 - 479 aa - 479 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.0281+/-0.000402; mu= -1.1355+/- 0.026 mean_var=301.6552+/-64.371, 0's: 0 Z-trim(120.9): 382 B-trim: 1772 in 1/59 Lambda= 0.073845 statistics sampled from 36359 (36859) to 36359 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.727), E-opt: 0.2 (0.432), width: 16 Scan time: 11.090 The best scores are: opt bits E(85289) NP_000732 (OMIM: 118495) muscarinic acetylcholine ( 479) 3162 350.2 7.2e-96 XP_011514071 (OMIM: 118493) PREDICTED: muscarinic ( 466) 1744 199.2 2.1e-50 NP_001006633 (OMIM: 118493) muscarinic acetylcholi ( 466) 1744 199.2 2.1e-50 NP_001006632 (OMIM: 118493) muscarinic acetylcholi ( 466) 1744 199.2 2.1e-50 NP_001006630 (OMIM: 118493) muscarinic acetylcholi ( 466) 1744 199.2 2.1e-50 NP_001006629 (OMIM: 118493) muscarinic acetylcholi ( 466) 1744 199.2 2.1e-50 NP_000730 (OMIM: 118493) muscarinic acetylcholine ( 466) 1744 199.2 2.1e-50 NP_001006628 (OMIM: 118493) muscarinic acetylcholi ( 466) 1744 199.2 2.1e-50 NP_001006627 (OMIM: 118493) muscarinic acetylcholi ( 466) 1744 199.2 2.1e-50 NP_001006631 (OMIM: 118493) muscarinic acetylcholi ( 466) 1744 199.2 2.1e-50 NP_036257 (OMIM: 118496) muscarinic acetylcholine ( 532) 961 115.8 3e-25 NP_001307846 (OMIM: 118496) muscarinic acetylcholi ( 532) 961 115.8 3e-25 XP_011542343 (OMIM: 100100,118494) PREDICTED: musc ( 590) 950 114.7 7.3e-25 XP_016855648 (OMIM: 100100,118494) PREDICTED: musc ( 590) 950 114.7 7.3e-25 XP_016855643 (OMIM: 100100,118494) PREDICTED: musc ( 590) 950 114.7 7.3e-25 XP_011542347 (OMIM: 100100,118494) PREDICTED: musc ( 590) 950 114.7 7.3e-25 XP_016855641 (OMIM: 100100,118494) PREDICTED: musc ( 590) 950 114.7 7.3e-25 XP_011542346 (OMIM: 100100,118494) PREDICTED: musc ( 590) 950 114.7 7.3e-25 XP_016855649 (OMIM: 100100,118494) PREDICTED: musc ( 590) 950 114.7 7.3e-25 XP_016855645 (OMIM: 100100,118494) PREDICTED: musc ( 590) 950 114.7 7.3e-25 XP_011542348 (OMIM: 100100,118494) PREDICTED: musc ( 590) 950 114.7 7.3e-25 XP_016855646 (OMIM: 100100,118494) PREDICTED: musc ( 590) 950 114.7 7.3e-25 XP_011542345 (OMIM: 100100,118494) PREDICTED: musc ( 590) 950 114.7 7.3e-25 XP_005273089 (OMIM: 100100,118494) PREDICTED: musc ( 590) 950 114.7 7.3e-25 XP_016855650 (OMIM: 100100,118494) PREDICTED: musc ( 590) 950 114.7 7.3e-25 XP_016855652 (OMIM: 100100,118494) PREDICTED: musc ( 590) 950 114.7 7.3e-25 XP_011542349 (OMIM: 100100,118494) PREDICTED: musc ( 590) 950 114.7 7.3e-25 XP_016855647 (OMIM: 100100,118494) PREDICTED: musc ( 590) 950 114.7 7.3e-25 XP_016855644 (OMIM: 100100,118494) PREDICTED: musc ( 590) 950 114.7 7.3e-25 XP_016855642 (OMIM: 100100,118494) PREDICTED: musc ( 590) 950 114.7 7.3e-25 XP_016855651 (OMIM: 100100,118494) PREDICTED: musc ( 590) 950 114.7 7.3e-25 NP_000731 (OMIM: 100100,118494) muscarinic acetylc ( 590) 950 114.7 7.3e-25 XP_011543044 (OMIM: 118510) PREDICTED: muscarinic ( 460) 935 113.0 1.8e-24 NP_000729 (OMIM: 118510) muscarinic acetylcholine ( 460) 935 113.0 1.8e-24 NP_009163 (OMIM: 604525) histamine H3 receptor [Ho ( 445) 502 66.8 1.4e-10 XP_005260323 (OMIM: 604525) PREDICTED: histamine H ( 453) 502 66.8 1.4e-10 NP_001091681 (OMIM: 600167) histamine H1 receptor ( 487) 450 61.3 6.9e-09 NP_000852 (OMIM: 600167) histamine H1 receptor [Ho ( 487) 450 61.3 6.9e-09 XP_016861773 (OMIM: 600167) PREDICTED: histamine H ( 487) 450 61.3 6.9e-09 XP_011531955 (OMIM: 600167) PREDICTED: histamine H ( 487) 450 61.3 6.9e-09 NP_001091683 (OMIM: 600167) histamine H1 receptor ( 487) 450 61.3 6.9e-09 XP_016861772 (OMIM: 600167) PREDICTED: histamine H ( 487) 450 61.3 6.9e-09 NP_001091682 (OMIM: 600167) histamine H1 receptor ( 487) 450 61.3 6.9e-09 XP_011531954 (OMIM: 600167) PREDICTED: histamine H ( 487) 450 61.3 6.9e-09 NP_000854 (OMIM: 182131) 5-hydroxytryptamine recep ( 390) 446 60.8 7.8e-09 XP_011542714 (OMIM: 104221) PREDICTED: alpha-1A ad ( 308) 432 59.2 1.9e-08 XP_016868585 (OMIM: 104221) PREDICTED: alpha-1A ad ( 317) 432 59.2 1.9e-08 XP_011542713 (OMIM: 104221) PREDICTED: alpha-1A ad ( 324) 432 59.3 1.9e-08 NP_001309433 (OMIM: 104221) alpha-1A adrenergic re ( 342) 432 59.3 2e-08 NP_001309432 (OMIM: 104221) alpha-1A adrenergic re ( 370) 432 59.3 2.1e-08 >>NP_000732 (OMIM: 118495) muscarinic acetylcholine rece (479 aa) initn: 3162 init1: 3162 opt: 3162 Z-score: 1842.1 bits: 350.2 E(85289): 7.2e-96 Smith-Waterman score: 3162; 100.0% identity (100.0% similar) in 479 aa overlap (1-479:1-479) 10 20 30 40 50 60 pF1KE9 MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 RQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 RQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 MNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 PDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 PDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 TLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 TLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 ATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 ATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE9 PATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 PATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMV 370 380 390 400 410 420 430 440 450 460 470 pF1KE9 LVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR 430 440 450 460 470 >>XP_011514071 (OMIM: 118493) PREDICTED: muscarinic acet (466 aa) initn: 1686 init1: 1158 opt: 1744 Z-score: 1025.9 bits: 199.2 E(85289): 2.1e-50 Smith-Waterman score: 1744; 57.7% identity (79.4% similar) in 480 aa overlap (7-479:1-466) 10 20 30 40 50 60 pF1KE9 MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVN .:.:..... :. .: :.: :.:::. :.:::::::..::::::.::::: XP_011 MNNSTNSSNNSLALTSP---YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVN 10 20 30 40 50 70 80 90 100 110 120 pF1KE9 RQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASV :.::::::::::::::::::::.:::::::.: . :::::: :::::::::::::::::: XP_011 RHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASV 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE9 MNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTV :::::::::::::::::::::..:::::::.::::::::::.:::::::::::.:: ::: XP_011 MNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTV 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE9 PDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAK :..:.:::.:: :::::::::::::::.:::::: ::: ::.::..: . : .. XP_011 EDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPV 180 190 200 210 220 230 250 260 270 280 290 pF1KE9 TLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVA--DKDTSNESSS . ..... ..: . .. : .. . :...:.... : : : .:..::.:.: XP_011 SPSLVQGRIVKPNNNNMPSSD---DGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTS 240 250 260 270 280 300 310 320 330 340 350 pF1KE9 GSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNE-CV--- ::. :... : : . .. . :. . :.: :: .. :. XP_011 VSAV-------ASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTN 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE9 TAIEIVPATPAGMRPAAN-VARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTW :..:.: .. . : ::::...... : ::. .::.::::::.:::::::.:: XP_011 TTVEVVGSSGQNGDEKQNIVARKIVKMTK-QPAKKKPPPSREKKVTRTILAILLAFIITW 350 360 370 380 390 400 420 430 440 450 460 470 pF1KE9 TPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYR .:::::::.:::: :::.:::.:::::::.::::::::::::::::::::.:::.:.:. XP_011 APYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYK 410 420 430 440 450 460 pF1KE9 NIGTAR :::..: XP_011 NIGATR >>NP_001006633 (OMIM: 118493) muscarinic acetylcholine r (466 aa) initn: 1686 init1: 1158 opt: 1744 Z-score: 1025.9 bits: 199.2 E(85289): 2.1e-50 Smith-Waterman score: 1744; 57.7% identity (79.4% similar) in 480 aa overlap (7-479:1-466) 10 20 30 40 50 60 pF1KE9 MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVN .:.:..... :. .: :.: :.:::. :.:::::::..::::::.::::: NP_001 MNNSTNSSNNSLALTSP---YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVN 10 20 30 40 50 70 80 90 100 110 120 pF1KE9 RQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASV :.::::::::::::::::::::.:::::::.: . :::::: :::::::::::::::::: NP_001 RHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASV 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE9 MNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTV :::::::::::::::::::::..:::::::.::::::::::.:::::::::::.:: ::: NP_001 MNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTV 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE9 PDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAK :..:.:::.:: :::::::::::::::.:::::: ::: ::.::..: . : .. NP_001 EDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPV 180 190 200 210 220 230 250 260 270 280 290 pF1KE9 TLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVA--DKDTSNESSS . ..... ..: . .. : .. . :...:.... : : : .:..::.:.: NP_001 SPSLVQGRIVKPNNNNMPSSD---DGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTS 240 250 260 270 280 300 310 320 330 340 350 pF1KE9 GSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNE-CV--- ::. :... : : . .. . :. . :.: :: .. :. NP_001 VSAV-------ASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTN 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE9 TAIEIVPATPAGMRPAAN-VARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTW :..:.: .. . : ::::...... : ::. .::.::::::.:::::::.:: NP_001 TTVEVVGSSGQNGDEKQNIVARKIVKMTK-QPAKKKPPPSREKKVTRTILAILLAFIITW 350 360 370 380 390 400 420 430 440 450 460 470 pF1KE9 TPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYR .:::::::.:::: :::.:::.:::::::.::::::::::::::::::::.:::.:.:. NP_001 APYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYK 410 420 430 440 450 460 pF1KE9 NIGTAR :::..: NP_001 NIGATR >>NP_001006632 (OMIM: 118493) muscarinic acetylcholine r (466 aa) initn: 1686 init1: 1158 opt: 1744 Z-score: 1025.9 bits: 199.2 E(85289): 2.1e-50 Smith-Waterman score: 1744; 57.7% identity (79.4% similar) in 480 aa overlap (7-479:1-466) 10 20 30 40 50 60 pF1KE9 MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVN .:.:..... :. .: :.: :.:::. :.:::::::..::::::.::::: NP_001 MNNSTNSSNNSLALTSP---YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVN 10 20 30 40 50 70 80 90 100 110 120 pF1KE9 RQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASV :.::::::::::::::::::::.:::::::.: . :::::: :::::::::::::::::: NP_001 RHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASV 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE9 MNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTV :::::::::::::::::::::..:::::::.::::::::::.:::::::::::.:: ::: NP_001 MNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTV 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE9 PDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAK :..:.:::.:: :::::::::::::::.:::::: ::: ::.::..: . : .. NP_001 EDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPV 180 190 200 210 220 230 250 260 270 280 290 pF1KE9 TLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVA--DKDTSNESSS . ..... ..: . .. : .. . :...:.... : : : .:..::.:.: NP_001 SPSLVQGRIVKPNNNNMPSSD---DGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTS 240 250 260 270 280 300 310 320 330 340 350 pF1KE9 GSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNE-CV--- ::. :... : : . .. . :. . :.: :: .. :. NP_001 VSAV-------ASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTN 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE9 TAIEIVPATPAGMRPAAN-VARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTW :..:.: .. . : ::::...... : ::. .::.::::::.:::::::.:: NP_001 TTVEVVGSSGQNGDEKQNIVARKIVKMTK-QPAKKKPPPSREKKVTRTILAILLAFIITW 350 360 370 380 390 400 420 430 440 450 460 470 pF1KE9 TPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYR .:::::::.:::: :::.:::.:::::::.::::::::::::::::::::.:::.:.:. NP_001 APYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYK 410 420 430 440 450 460 pF1KE9 NIGTAR :::..: NP_001 NIGATR >>NP_001006630 (OMIM: 118493) muscarinic acetylcholine r (466 aa) initn: 1686 init1: 1158 opt: 1744 Z-score: 1025.9 bits: 199.2 E(85289): 2.1e-50 Smith-Waterman score: 1744; 57.7% identity (79.4% similar) in 480 aa overlap (7-479:1-466) 10 20 30 40 50 60 pF1KE9 MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVN .:.:..... :. .: :.: :.:::. :.:::::::..::::::.::::: NP_001 MNNSTNSSNNSLALTSP---YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVN 10 20 30 40 50 70 80 90 100 110 120 pF1KE9 RQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASV :.::::::::::::::::::::.:::::::.: . :::::: :::::::::::::::::: NP_001 RHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASV 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE9 MNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTV :::::::::::::::::::::..:::::::.::::::::::.:::::::::::.:: ::: NP_001 MNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTV 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE9 PDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAK :..:.:::.:: :::::::::::::::.:::::: ::: ::.::..: . : .. NP_001 EDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPV 180 190 200 210 220 230 250 260 270 280 290 pF1KE9 TLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVA--DKDTSNESSS . ..... ..: . .. : .. . :...:.... : : : .:..::.:.: NP_001 SPSLVQGRIVKPNNNNMPSSD---DGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTS 240 250 260 270 280 300 310 320 330 340 350 pF1KE9 GSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNE-CV--- ::. :... : : . .. . :. . :.: :: .. :. NP_001 VSAV-------ASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTN 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE9 TAIEIVPATPAGMRPAAN-VARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTW :..:.: .. . : ::::...... : ::. .::.::::::.:::::::.:: NP_001 TTVEVVGSSGQNGDEKQNIVARKIVKMTK-QPAKKKPPPSREKKVTRTILAILLAFIITW 350 360 370 380 390 400 420 430 440 450 460 470 pF1KE9 TPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYR .:::::::.:::: :::.:::.:::::::.::::::::::::::::::::.:::.:.:. NP_001 APYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYK 410 420 430 440 450 460 pF1KE9 NIGTAR :::..: NP_001 NIGATR >>NP_001006629 (OMIM: 118493) muscarinic acetylcholine r (466 aa) initn: 1686 init1: 1158 opt: 1744 Z-score: 1025.9 bits: 199.2 E(85289): 2.1e-50 Smith-Waterman score: 1744; 57.7% identity (79.4% similar) in 480 aa overlap (7-479:1-466) 10 20 30 40 50 60 pF1KE9 MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVN .:.:..... :. .: :.: :.:::. :.:::::::..::::::.::::: NP_001 MNNSTNSSNNSLALTSP---YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVN 10 20 30 40 50 70 80 90 100 110 120 pF1KE9 RQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASV :.::::::::::::::::::::.:::::::.: . :::::: :::::::::::::::::: NP_001 RHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASV 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE9 MNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTV :::::::::::::::::::::..:::::::.::::::::::.:::::::::::.:: ::: NP_001 MNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTV 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE9 PDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAK :..:.:::.:: :::::::::::::::.:::::: ::: ::.::..: . : .. NP_001 EDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPV 180 190 200 210 220 230 250 260 270 280 290 pF1KE9 TLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVA--DKDTSNESSS . ..... ..: . .. : .. . :...:.... : : : .:..::.:.: NP_001 SPSLVQGRIVKPNNNNMPSSD---DGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTS 240 250 260 270 280 300 310 320 330 340 350 pF1KE9 GSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNE-CV--- ::. :... : : . .. . :. . :.: :: .. :. NP_001 VSAV-------ASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTN 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE9 TAIEIVPATPAGMRPAAN-VARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTW :..:.: .. . : ::::...... : ::. .::.::::::.:::::::.:: NP_001 TTVEVVGSSGQNGDEKQNIVARKIVKMTK-QPAKKKPPPSREKKVTRTILAILLAFIITW 350 360 370 380 390 400 420 430 440 450 460 470 pF1KE9 TPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYR .:::::::.:::: :::.:::.:::::::.::::::::::::::::::::.:::.:.:. NP_001 APYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYK 410 420 430 440 450 460 pF1KE9 NIGTAR :::..: NP_001 NIGATR >>NP_000730 (OMIM: 118493) muscarinic acetylcholine rece (466 aa) initn: 1686 init1: 1158 opt: 1744 Z-score: 1025.9 bits: 199.2 E(85289): 2.1e-50 Smith-Waterman score: 1744; 57.7% identity (79.4% similar) in 480 aa overlap (7-479:1-466) 10 20 30 40 50 60 pF1KE9 MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVN .:.:..... :. .: :.: :.:::. :.:::::::..::::::.::::: NP_000 MNNSTNSSNNSLALTSP---YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVN 10 20 30 40 50 70 80 90 100 110 120 pF1KE9 RQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASV :.::::::::::::::::::::.:::::::.: . :::::: :::::::::::::::::: NP_000 RHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASV 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE9 MNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTV :::::::::::::::::::::..:::::::.::::::::::.:::::::::::.:: ::: NP_000 MNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTV 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE9 PDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAK :..:.:::.:: :::::::::::::::.:::::: ::: ::.::..: . : .. NP_000 EDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPV 180 190 200 210 220 230 250 260 270 280 290 pF1KE9 TLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVA--DKDTSNESSS . ..... ..: . .. : .. . :...:.... : : : .:..::.:.: NP_000 SPSLVQGRIVKPNNNNMPSSD---DGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTS 240 250 260 270 280 300 310 320 330 340 350 pF1KE9 GSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNE-CV--- ::. :... : : . .. . :. . :.: :: .. :. NP_000 VSAV-------ASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTN 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE9 TAIEIVPATPAGMRPAAN-VARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTW :..:.: .. . : ::::...... : ::. .::.::::::.:::::::.:: NP_000 TTVEVVGSSGQNGDEKQNIVARKIVKMTK-QPAKKKPPPSREKKVTRTILAILLAFIITW 350 360 370 380 390 400 420 430 440 450 460 470 pF1KE9 TPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYR .:::::::.:::: :::.:::.:::::::.::::::::::::::::::::.:::.:.:. NP_000 APYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYK 410 420 430 440 450 460 pF1KE9 NIGTAR :::..: NP_000 NIGATR >>NP_001006628 (OMIM: 118493) muscarinic acetylcholine r (466 aa) initn: 1686 init1: 1158 opt: 1744 Z-score: 1025.9 bits: 199.2 E(85289): 2.1e-50 Smith-Waterman score: 1744; 57.7% identity (79.4% similar) in 480 aa overlap (7-479:1-466) 10 20 30 40 50 60 pF1KE9 MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVN .:.:..... :. .: :.: :.:::. :.:::::::..::::::.::::: NP_001 MNNSTNSSNNSLALTSP---YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVN 10 20 30 40 50 70 80 90 100 110 120 pF1KE9 RQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASV :.::::::::::::::::::::.:::::::.: . :::::: :::::::::::::::::: NP_001 RHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASV 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE9 MNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTV :::::::::::::::::::::..:::::::.::::::::::.:::::::::::.:: ::: NP_001 MNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTV 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE9 PDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAK :..:.:::.:: :::::::::::::::.:::::: ::: ::.::..: . : .. NP_001 EDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPV 180 190 200 210 220 230 250 260 270 280 290 pF1KE9 TLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVA--DKDTSNESSS . ..... ..: . .. : .. . :...:.... : : : .:..::.:.: NP_001 SPSLVQGRIVKPNNNNMPSSD---DGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTS 240 250 260 270 280 300 310 320 330 340 350 pF1KE9 GSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNE-CV--- ::. :... : : . .. . :. . :.: :: .. :. NP_001 VSAV-------ASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTN 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE9 TAIEIVPATPAGMRPAAN-VARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTW :..:.: .. . : ::::...... : ::. .::.::::::.:::::::.:: NP_001 TTVEVVGSSGQNGDEKQNIVARKIVKMTK-QPAKKKPPPSREKKVTRTILAILLAFIITW 350 360 370 380 390 400 420 430 440 450 460 470 pF1KE9 TPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYR .:::::::.:::: :::.:::.:::::::.::::::::::::::::::::.:::.:.:. NP_001 APYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYK 410 420 430 440 450 460 pF1KE9 NIGTAR :::..: NP_001 NIGATR >>NP_001006627 (OMIM: 118493) muscarinic acetylcholine r (466 aa) initn: 1686 init1: 1158 opt: 1744 Z-score: 1025.9 bits: 199.2 E(85289): 2.1e-50 Smith-Waterman score: 1744; 57.7% identity (79.4% similar) in 480 aa overlap (7-479:1-466) 10 20 30 40 50 60 pF1KE9 MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVN .:.:..... :. .: :.: :.:::. :.:::::::..::::::.::::: NP_001 MNNSTNSSNNSLALTSP---YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVN 10 20 30 40 50 70 80 90 100 110 120 pF1KE9 RQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASV :.::::::::::::::::::::.:::::::.: . :::::: :::::::::::::::::: NP_001 RHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASV 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE9 MNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTV :::::::::::::::::::::..:::::::.::::::::::.:::::::::::.:: ::: NP_001 MNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTV 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE9 PDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAK :..:.:::.:: :::::::::::::::.:::::: ::: ::.::..: . : .. NP_001 EDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPV 180 190 200 210 220 230 250 260 270 280 290 pF1KE9 TLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVA--DKDTSNESSS . ..... ..: . .. : .. . :...:.... : : : .:..::.:.: NP_001 SPSLVQGRIVKPNNNNMPSSD---DGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTS 240 250 260 270 280 300 310 320 330 340 350 pF1KE9 GSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNE-CV--- ::. :... : : . .. . :. . :.: :: .. :. NP_001 VSAV-------ASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTN 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE9 TAIEIVPATPAGMRPAAN-VARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTW :..:.: .. . : ::::...... : ::. .::.::::::.:::::::.:: NP_001 TTVEVVGSSGQNGDEKQNIVARKIVKMTK-QPAKKKPPPSREKKVTRTILAILLAFIITW 350 360 370 380 390 400 420 430 440 450 460 470 pF1KE9 TPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYR .:::::::.:::: :::.:::.:::::::.::::::::::::::::::::.:::.:.:. NP_001 APYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYK 410 420 430 440 450 460 pF1KE9 NIGTAR :::..: NP_001 NIGATR >>NP_001006631 (OMIM: 118493) muscarinic acetylcholine r (466 aa) initn: 1686 init1: 1158 opt: 1744 Z-score: 1025.9 bits: 199.2 E(85289): 2.1e-50 Smith-Waterman score: 1744; 57.7% identity (79.4% similar) in 480 aa overlap (7-479:1-466) 10 20 30 40 50 60 pF1KE9 MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVN .:.:..... :. .: :.: :.:::. :.:::::::..::::::.::::: NP_001 MNNSTNSSNNSLALTSP---YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVN 10 20 30 40 50 70 80 90 100 110 120 pF1KE9 RQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASV :.::::::::::::::::::::.:::::::.: . :::::: :::::::::::::::::: NP_001 RHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASV 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE9 MNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTV :::::::::::::::::::::..:::::::.::::::::::.:::::::::::.:: ::: NP_001 MNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTV 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE9 PDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAK :..:.:::.:: :::::::::::::::.:::::: ::: ::.::..: . : .. NP_001 EDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPV 180 190 200 210 220 230 250 260 270 280 290 pF1KE9 TLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVA--DKDTSNESSS . ..... ..: . .. : .. . :...:.... : : : .:..::.:.: NP_001 SPSLVQGRIVKPNNNNMPSSD---DGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTS 240 250 260 270 280 300 310 320 330 340 350 pF1KE9 GSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNE-CV--- ::. :... : : . .. . :. . :.: :: .. :. NP_001 VSAV-------ASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTN 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE9 TAIEIVPATPAGMRPAAN-VARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTW :..:.: .. . : ::::...... : ::. .::.::::::.:::::::.:: NP_001 TTVEVVGSSGQNGDEKQNIVARKIVKMTK-QPAKKKPPPSREKKVTRTILAILLAFIITW 350 360 370 380 390 400 420 430 440 450 460 470 pF1KE9 TPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYR .:::::::.:::: :::.:::.:::::::.::::::::::::::::::::.:::.:.:. NP_001 APYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYK 410 420 430 440 450 460 pF1KE9 NIGTAR :::..: NP_001 NIGATR 479 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 10:47:54 2016 done: Sun Nov 6 10:47:56 2016 Total Scan time: 11.090 Total Display time: 0.110 Function used was FASTA [36.3.4 Apr, 2011]