FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2086, 760 aa 1>>>pF1KE2086 760 - 760 aa - 760 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3101+/-0.000481; mu= 20.6652+/- 0.030 mean_var=74.4405+/-15.083, 0's: 0 Z-trim(109.4): 57 B-trim: 705 in 1/52 Lambda= 0.148652 statistics sampled from 17491 (17548) to 17491 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.55), E-opt: 0.2 (0.206), width: 16 Scan time: 11.680 The best scores are: opt bits E(85289) NP_000391 (OMIM: 126340,278730,601675,610756) TFII ( 760) 4988 1080.0 0 XP_016881956 (OMIM: 126340,278730,601675,610756) P ( 719) 4711 1020.6 0 XP_011524913 (OMIM: 126340,278730,601675,610756) P ( 734) 4591 994.8 0 NP_001124339 (OMIM: 126340,278730,601675,610756) T ( 405) 2556 558.2 2.4e-158 XP_016880689 (OMIM: 114480,189960,605882,609054) P (1088) 594 137.8 2.4e-31 NP_114432 (OMIM: 114480,189960,605882,609054) Fanc (1249) 594 137.8 2.7e-31 XP_011523637 (OMIM: 114480,189960,605882,609054) P (1249) 576 133.9 3.9e-30 NP_116575 (OMIM: 608833,615190,616373) regulator o (1243) 532 124.5 2.7e-27 NP_057518 (OMIM: 608833,615190,616373) regulator o (1219) 517 121.3 2.4e-26 NP_001269938 (OMIM: 608833,615190,616373) regulato (1300) 517 121.3 2.6e-26 XP_016874420 (OMIM: 601150,613398) PREDICTED: prob ( 931) 414 99.1 8.8e-20 XP_006719113 (OMIM: 601150,613398) PREDICTED: prob ( 967) 414 99.1 9.1e-20 NP_001244074 (OMIM: 601150,613398) probable ATP-de ( 880) 409 98.0 1.8e-19 NP_085911 (OMIM: 601150,613398) probable ATP-depen ( 906) 409 98.0 1.8e-19 XP_016874421 (OMIM: 601150,613398) PREDICTED: prob ( 906) 409 98.0 1.8e-19 XP_005253390 (OMIM: 601150,613398) PREDICTED: prob ( 942) 409 98.0 1.9e-19 XP_016874417 (OMIM: 601150,613398) PREDICTED: prob (1027) 409 98.1 2e-19 XP_016874419 (OMIM: 601150,613398) PREDICTED: prob (1002) 404 97.0 4.1e-19 NP_001269939 (OMIM: 608833,615190,616373) regulato ( 996) 377 91.2 2.3e-17 XP_016874418 (OMIM: 601150,613398) PREDICTED: prob (1014) 343 83.9 3.6e-15 XP_016880691 (OMIM: 114480,189960,605882,609054) P ( 631) 338 82.7 5.2e-15 XP_016880692 (OMIM: 114480,189960,605882,609054) P ( 631) 338 82.7 5.2e-15 XP_016880690 (OMIM: 114480,189960,605882,609054) P (1088) 338 82.9 8e-15 XP_011523640 (OMIM: 114480,189960,605882,609054) P (1108) 338 82.9 8.1e-15 XP_011523639 (OMIM: 114480,189960,605882,609054) P (1202) 338 82.9 8.7e-15 XP_011523636 (OMIM: 114480,189960,605882,609054) P (1269) 338 82.9 9e-15 XP_011523635 (OMIM: 114480,189960,605882,609054) P (1269) 338 82.9 9e-15 XP_011523634 (OMIM: 114480,189960,605882,609054) P (1269) 338 82.9 9e-15 XP_011523638 (OMIM: 114480,189960,605882,609054) P (1229) 320 79.0 1.3e-13 XP_016874423 (OMIM: 601150,613398) PREDICTED: prob ( 831) 309 76.6 4.8e-13 NP_001244073 (OMIM: 601150,613398) probable ATP-de ( 970) 309 76.6 5.5e-13 NP_689651 (OMIM: 601150,613398) probable ATP-depen ( 970) 309 76.6 5.5e-13 XP_005253388 (OMIM: 601150,613398) PREDICTED: prob (1006) 309 76.6 5.6e-13 XP_011518894 (OMIM: 601150,613398) PREDICTED: prob (1031) 309 76.6 5.7e-13 XP_016874425 (OMIM: 601150,613398) PREDICTED: prob ( 768) 304 75.5 9.5e-13 XP_016874426 (OMIM: 601150,613398) PREDICTED: prob ( 768) 304 75.5 9.5e-13 XP_016874424 (OMIM: 601150,613398) PREDICTED: prob ( 768) 304 75.5 9.5e-13 XP_016874422 (OMIM: 601150,613398) PREDICTED: prob ( 847) 304 75.5 1e-12 XP_016874414 (OMIM: 601150,613398) PREDICTED: prob (1055) 304 75.6 1.2e-12 XP_016874411 (OMIM: 601150,613398) PREDICTED: prob (1055) 304 75.6 1.2e-12 XP_016874412 (OMIM: 601150,613398) PREDICTED: prob (1055) 304 75.6 1.2e-12 XP_016874413 (OMIM: 601150,613398) PREDICTED: prob (1055) 304 75.6 1.2e-12 XP_016874410 (OMIM: 601150,613398) PREDICTED: prob (1066) 304 75.6 1.2e-12 XP_016874408 (OMIM: 601150,613398) PREDICTED: prob (1091) 304 75.6 1.3e-12 XP_016874407 (OMIM: 601150,613398) PREDICTED: prob (1091) 304 75.6 1.3e-12 NP_004390 (OMIM: 601150,613398) probable ATP-depen ( 856) 280 70.4 3.7e-11 XP_011518897 (OMIM: 601150,613398) PREDICTED: prob ( 892) 280 70.4 3.8e-11 XP_011523642 (OMIM: 114480,189960,605882,609054) P ( 853) 261 66.3 6.2e-10 XP_011523641 (OMIM: 114480,189960,605882,609054) P ( 872) 252 64.4 2.4e-09 XP_016874409 (OMIM: 601150,613398) PREDICTED: prob (1078) 247 63.3 6e-09 >>NP_000391 (OMIM: 126340,278730,601675,610756) TFIIH ba (760 aa) initn: 4988 init1: 4988 opt: 4988 Z-score: 5778.8 bits: 1080.0 E(85289): 0 Smith-Waterman score: 4988; 99.7% identity (100.0% similar) in 760 aa overlap (1-760:1-760) 10 20 30 40 50 60 pF1KE2 MKLNVDGLLVYFPYDYIYPEQFSYMRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MKLNVDGLLVYFPYDYIYPEQFSYMRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 RAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 RAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 VTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 VTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 KALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 KALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNID 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 NVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 NVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 TDAHLANPVLPNEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSG :::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::: NP_000 TDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 LAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 FDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 FDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMAT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 FTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 FTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFT 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 SYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 SYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVA 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 RGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 RGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHA 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 AQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 AQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYF 670 680 690 700 710 720 730 740 750 760 pF1KE2 LRQMAQPFHREDQLGLSLLSLEQLESEETLQRIEQIAQQL ::::::::::::::::::::::::::::::.::::::::: NP_000 LRQMAQPFHREDQLGLSLLSLEQLESEETLKRIEQIAQQL 730 740 750 760 >>XP_016881956 (OMIM: 126340,278730,601675,610756) PREDI (719 aa) initn: 4711 init1: 4711 opt: 4711 Z-score: 5458.1 bits: 1020.6 E(85289): 0 Smith-Waterman score: 4711; 99.7% identity (100.0% similar) in 719 aa overlap (42-760:1-719) 20 30 40 50 60 70 pF1KE2 FPYDYIYPEQFSYMRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLI :::::::::::::::::::::::::::::: XP_016 MPSGTGKTVSLLALIMAYQRAYPLEVTKLI 10 20 30 80 90 100 110 120 130 pF1KE2 YCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVD 40 50 60 70 80 90 140 150 160 170 180 190 pF1KE2 GKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDLKALGRRQGWCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDLKALGRRQGWCP 100 110 120 130 140 150 200 210 220 230 240 250 pF1KE2 YFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNL 160 170 180 190 200 210 260 270 280 290 300 310 pF1KE2 TRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLP 220 230 240 250 260 270 320 330 340 350 360 370 pF1KE2 NEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKP .::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKP 280 290 300 310 320 330 380 390 400 410 420 430 pF1KE2 LRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANP 340 350 360 370 380 390 440 450 460 470 480 490 pF1KE2 ILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLARVCLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLARVCLC 400 410 420 430 440 450 500 510 520 530 540 550 pF1KE2 PMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVAS 460 470 480 490 500 510 560 570 580 590 600 610 pF1KE2 WYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFV 520 530 540 550 560 570 620 630 640 650 660 670 pF1KE2 HHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGK 580 590 600 610 620 630 680 690 700 710 720 730 pF1KE2 TDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYFLRQMAQPFHRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYFLRQMAQPFHRE 640 650 660 670 680 690 740 750 760 pF1KE2 DQLGLSLLSLEQLESEETLQRIEQIAQQL :::::::::::::::::::.::::::::: XP_016 DQLGLSLLSLEQLESEETLKRIEQIAQQL 700 710 >>XP_011524913 (OMIM: 126340,278730,601675,610756) PREDI (734 aa) initn: 4591 init1: 4591 opt: 4591 Z-score: 5318.9 bits: 994.8 E(85289): 0 Smith-Waterman score: 4761; 96.3% identity (96.6% similar) in 760 aa overlap (1-760:1-734) 10 20 30 40 50 60 pF1KE2 MKLNVDGLLVYFPYDYIYPEQFSYMRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQ ::::::::::::::::::::::::::::::::::: XP_011 MKLNVDGLLVYFPYDYIYPEQFSYMRELKRTLDAK------------------------- 10 20 30 70 80 90 100 110 120 pF1KE2 RAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPE ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 -AYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPE 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE2 VTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDL 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE2 KALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNID 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE2 NVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARE 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE2 TDAHLANPVLPNEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSG :::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSG 280 290 300 310 320 330 370 380 390 400 410 420 pF1KE2 LAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEP 340 350 360 370 380 390 430 440 450 460 470 480 pF1KE2 FDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMAT 400 410 420 430 440 450 490 500 510 520 530 540 pF1KE2 FTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFT 460 470 480 490 500 510 550 560 570 580 590 600 pF1KE2 SYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVA 520 530 540 550 560 570 610 620 630 640 650 660 pF1KE2 RGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHA 580 590 600 610 620 630 670 680 690 700 710 720 pF1KE2 AQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYF 640 650 660 670 680 690 730 740 750 760 pF1KE2 LRQMAQPFHREDQLGLSLLSLEQLESEETLQRIEQIAQQL ::::::::::::::::::::::::::::::.::::::::: XP_011 LRQMAQPFHREDQLGLSLLSLEQLESEETLKRIEQIAQQL 700 710 720 730 >>NP_001124339 (OMIM: 126340,278730,601675,610756) TFIIH (405 aa) initn: 2556 init1: 2556 opt: 2556 Z-score: 2963.9 bits: 558.2 E(85289): 2.4e-158 Smith-Waterman score: 2556; 99.7% identity (100.0% similar) in 389 aa overlap (25-413:1-389) 10 20 30 40 50 60 pF1KE2 MKLNVDGLLVYFPYDYIYPEQFSYMRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQ :::::::::::::::::::::::::::::::::::: NP_001 MRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQ 10 20 30 70 80 90 100 110 120 pF1KE2 RAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPE 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE2 VTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDL 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE2 KALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNID 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE2 NVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARE 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE2 TDAHLANPVLPNEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSG :::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSG 280 290 300 310 320 330 370 380 390 400 410 420 pF1KE2 LAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEP ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGQAQHCGS 340 350 360 370 380 390 430 440 450 460 470 480 pF1KE2 FDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMAT NP_001 SRNQKRSHP 400 >>XP_016880689 (OMIM: 114480,189960,605882,609054) PREDI (1088 aa) initn: 506 init1: 133 opt: 594 Z-score: 683.8 bits: 137.8 E(85289): 2.4e-31 Smith-Waterman score: 638; 26.5% identity (54.2% similar) in 672 aa overlap (66-701:81-707) 40 50 60 70 80 90 pF1KE2 GHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYE .. :. . .:: .: .. .:::. XP_016 GHCSRCCCSTKQGNSQESSNTIKKDHTGKSKIPKIYFGTRTHKQIAQITRELRR-----T 60 70 80 90 100 100 110 120 130 140 150 pF1KE2 KQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHC : .:. :::: . :.::::. :... :: : . .. : : XP_016 AYSG--VPM--TILSSRDHTCVHPEVVG-NFNRNE--KCMELLDG------KNGKS---C 110 120 130 140 160 170 180 190 200 210 pF1KE2 RFYEEFDAHGREVPLPA--GI---YNLDDLKALGRRQGWCPYFLARYSILHANVVVYSYH ::. . . : . :. .....: .::.. :::. :: : :... :. XP_016 YFYHGVHKISDQHTLQTFQGMCKAWDIEELVSLGKKLKACPYYTARELIQDADIIFCPYN 150 160 170 180 190 200 220 230 240 250 260 270 pF1KE2 YLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTV :::: .: . .. .: .. ::..::::::.. .: : ..:. : . .:... .. XP_016 YLLDAQIRESMDLNL-KEQVVILDEAHNIEDCARESASYSVTEVQLRFARDELDSMVNNN 210 220 230 240 250 260 280 290 300 310 320 pF1KE2 LRIKETDEQRLRDEYRRLVEGLREASAAR--ETDAHLANPVLP-NEVLQEAVPGSIRTAE .: : :.. :: :.. : ::.: : : . : . ::.: .: :: XP_016 IRKK--DHEPLRAVCCSLINWL-EANAEYLVERDYESACKIWSGNEMLLTLHKMGITTAT 270 280 290 300 310 320 330 340 350 360 370 pF1KE2 ------HFLGFLRRLLE----YVKWRLRVQHVVQESPPAFLSGLAQRV-CIQRKPLRFCA :: . :.. . : : . : :.. : .:.:: . . . :. :: XP_016 FPILQGHFSAVLQKEEKISPIYGKEEAREVPVISASTQIMLKGLFMVLDYLFRQNSRFAD 330 340 350 360 370 380 380 390 400 410 420 430 pF1KE2 ERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPILHFS . .. .: :. :.: .:. .. . : .:.: XP_016 DYKIAIQQTYSWTNQIDISD--------------KNGLLVLPKNKKRSRQKTAVHVLNFW 390 400 410 420 430 440 450 460 470 480 490 pF1KE2 CMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLA--RVCLCPMI :.. ..:.. . . :....:::::::. . . : .:::. : .. .. XP_016 CLNPAVAFSDINGKVQTIVLTSGTLSPMKSFSSELG------VTFTIQLEANHIIKNSQV 440 450 460 470 480 500 510 520 530 540 550 pF1KE2 ----IGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVA :: : . . :.. : . . : ::: . .: .::. :. ::. .:. XP_016 WVGTIGSGPKGRNLCATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKE 490 500 510 520 530 540 560 570 580 590 600 pF1KE2 SWYEQGILENIQRNKLLFIETQDGAETSVA--LEKYQEACE-NGR--GAILLSVARGKVS : :. .:.. : ...: : : .:. :. : .: . .:. ::.:..: ::::: XP_016 RWLSTGLWHNLELVKTVIVEPQGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCRGKVS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 EGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRE----NDFLTFDAMRHAA ::.:: .:::: .:.:. ... .. . .: . ..: .. ..:.: XP_016 EGLDFSDDNARAVITIGIPFPNVKDLQVELKRQYNDHHSKLRGLLPGRQWYEIQAYRALN 610 620 630 640 650 660 670 680 690 700 710 pF1KE2 QCVGRAIRGKTDYGLMVFADKRFARGDKR--GKLPRWIQEHLTDANLNLTVDEGVQVAKY : .:: :: ..:.: ....: :: . .: . : .:..... XP_016 QALGRCIRHRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSK 670 680 690 700 710 720 720 730 740 750 760 pF1KE2 FLRQMAQPFHREDQLGLSLLSLEQLESEETLQRIEQIAQQL XP_016 KHQKVLNVSIKDRTNIQDNESTLEVTSLKYSTSPYLLEAASHLSPENFVEDEAKICVQEL 730 740 750 760 770 780 >>NP_114432 (OMIM: 114480,189960,605882,609054) Fanconi (1249 aa) initn: 544 init1: 133 opt: 594 Z-score: 683.0 bits: 137.8 E(85289): 2.7e-31 Smith-Waterman score: 638; 26.5% identity (54.2% similar) in 672 aa overlap (66-701:242-868) 40 50 60 70 80 90 pF1KE2 GHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYE .. :. . .:: .: .. .:::. NP_114 GHCSRCCCSTKQGNSQESSNTIKKDHTGKSKIPKIYFGTRTHKQIAQITRELRR-----T 220 230 240 250 260 100 110 120 130 140 150 pF1KE2 KQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHC : .:. :::: . :.::::. :... :: : . .. : : NP_114 AYSG--VPM--TILSSRDHTCVHPEVVG-NFNRNE--KCMELLDG------KNGKS---C 270 280 290 300 310 160 170 180 190 200 210 pF1KE2 RFYEEFDAHGREVPLPA--GI---YNLDDLKALGRRQGWCPYFLARYSILHANVVVYSYH ::. . . : . :. .....: .::.. :::. :: : :... :. NP_114 YFYHGVHKISDQHTLQTFQGMCKAWDIEELVSLGKKLKACPYYTARELIQDADIIFCPYN 320 330 340 350 360 370 220 230 240 250 260 270 pF1KE2 YLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTV :::: .: . .. .: .. ::..::::::.. .: : ..:. : . .:... .. NP_114 YLLDAQIRESMDLNL-KEQVVILDEAHNIEDCARESASYSVTEVQLRFARDELDSMVNNN 380 390 400 410 420 280 290 300 310 320 pF1KE2 LRIKETDEQRLRDEYRRLVEGLREASAAR--ETDAHLANPVLP-NEVLQEAVPGSIRTAE .: : :.. :: :.. : ::.: : : . : . ::.: .: :: NP_114 IRKK--DHEPLRAVCCSLINWL-EANAEYLVERDYESACKIWSGNEMLLTLHKMGITTAT 430 440 450 460 470 480 330 340 350 360 370 pF1KE2 ------HFLGFLRRLLE----YVKWRLRVQHVVQESPPAFLSGLAQRV-CIQRKPLRFCA :: . :.. . : : . : :.. : .:.:: . . . :. :: NP_114 FPILQGHFSAVLQKEEKISPIYGKEEAREVPVISASTQIMLKGLFMVLDYLFRQNSRFAD 490 500 510 520 530 540 380 390 400 410 420 430 pF1KE2 ERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPILHFS . .. .: :. :.: .:. .. . : .:.: NP_114 DYKIAIQQTYSWTNQIDISD--------------KNGLLVLPKNKKRSRQKTAVHVLNFW 550 560 570 580 590 440 450 460 470 480 490 pF1KE2 CMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLA--RVCLCPMI :.. ..:.. . . :....:::::::. . . : .:::. : .. .. NP_114 CLNPAVAFSDINGKVQTIVLTSGTLSPMKSFSSELG------VTFTIQLEANHIIKNSQV 600 610 620 630 640 500 510 520 530 540 550 pF1KE2 ----IGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVA :: : . . :.. : . . : ::: . .: .::. :. ::. .:. NP_114 WVGTIGSGPKGRNLCATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKE 650 660 670 680 690 700 560 570 580 590 600 pF1KE2 SWYEQGILENIQRNKLLFIETQDGAETSVA--LEKYQEACE-NGR--GAILLSVARGKVS : :. .:.. : ...: : : .:. :. : .: . .:. ::.:..: ::::: NP_114 RWLSTGLWHNLELVKTVIVEPQGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCRGKVS 710 720 730 740 750 760 610 620 630 640 650 660 pF1KE2 EGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRE----NDFLTFDAMRHAA ::.:: .:::: .:.:. ... .. . .: . ..: .. ..:.: NP_114 EGLDFSDDNARAVITIGIPFPNVKDLQVELKRQYNDHHSKLRGLLPGRQWYEIQAYRALN 770 780 790 800 810 820 670 680 690 700 710 pF1KE2 QCVGRAIRGKTDYGLMVFADKRFARGDKR--GKLPRWIQEHLTDANLNLTVDEGVQVAKY : .:: :: ..:.: ....: :: . .: . : .:..... NP_114 QALGRCIRHRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSK 830 840 850 860 870 880 720 730 740 750 760 pF1KE2 FLRQMAQPFHREDQLGLSLLSLEQLESEETLQRIEQIAQQL NP_114 KHQKVLNVSIKDRTNIQDNESTLEVTSLKYSTSPYLLEAASHLSPENFVEDEAKICVQEL 890 900 910 920 930 940 >>XP_011523637 (OMIM: 114480,189960,605882,609054) PREDI (1249 aa) initn: 516 init1: 133 opt: 576 Z-score: 662.1 bits: 133.9 E(85289): 3.9e-30 Smith-Waterman score: 619; 26.3% identity (54.2% similar) in 668 aa overlap (66-701:242-868) 40 50 60 70 80 90 pF1KE2 GHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYE .. :. . .:: .: .. .:::. XP_011 GHCSRCCCSTKQGNSQESSNTIKKDHTGKSKIPKIYFGTRTHKQIAQITRELRR-----T 220 230 240 250 260 100 110 120 130 140 150 pF1KE2 KQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHC : .:. :::: . :.::::. :... :: : . .. : : XP_011 AYSG--VPM--TILSSRDHTCVHPEVVG-NFNRNE--KCMELLDG------KNGKS---C 270 280 290 300 310 160 170 180 190 200 210 pF1KE2 RFYEEFDAHGREVPLPA--GI---YNLDDLKALGRRQGWCPYFLARYSILHANVVVYSYH ::. . . : . :. .....: .::.. :::. :: : :... :. XP_011 YFYHGVHKISDQHTLQTFQGMCKAWDIEELVSLGKKLKACPYYTARELIQDADIIFCPYN 320 330 340 350 360 370 220 230 240 250 260 270 pF1KE2 YLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTV :::: .: . .. .: .. ::..::::::.. .: : ..:. : . .:... .. XP_011 YLLDAQIRESMDLNL-KEQVVILDEAHNIEDCARESASYSVTEVQLRFARDELDSMVNNN 380 390 400 410 420 280 290 300 310 320 pF1KE2 LRIKETDEQRLRDEYRRLVEGLREASAAR--ETDAHLANPVLP-NEVLQEAVPGSIRTAE .: : :.. :: :.. : ::.: : : . : . ::.: .: :: XP_011 IRKK--DHEPLRAVCCSLINWL-EANAEYLVERDYESACKIWSGNEMLLTLHKMGITTAT 430 440 450 460 470 480 330 340 350 360 370 pF1KE2 ------HFLGFLRRLLE----YVKWRLRVQHVVQESPPAFLSGLAQRV-CIQRKPLRFCA :: . :.. . : : . : :.. : .:.:: . . . :. :: XP_011 FPILQGHFSAVLQKEEKISPIYGKEEAREVPVISASTQIMLKGLFMVLDYLFRQNSRFAD 490 500 510 520 530 540 380 390 400 410 420 430 pF1KE2 ERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPILHFS . .. .: :. :.: .:. .. . : .:.: XP_011 DYKIAIQQTYSWTNQIDISD--------------KNGLLVLPKNKKRSRQKTAVHVLNFW 550 560 570 580 590 440 450 460 470 480 490 pF1KE2 CMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILD--FHPVTMATFTMTLARVCLCPMI :.. ..:.. . . :....:::::::. . . : : :. . ... .: XP_011 CLNPAVAFSDINGKVQTIVLTSGTLSPMKSFSSELGVTFTIQLEANHIIKNSQIMSSKFI 600 610 620 630 640 650 500 510 520 530 540 550 pF1KE2 IGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYE : : :.... : . . : ::: . .: .::. :. ::. .:. : XP_011 IYVVA--CARVSSLKNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLS 660 670 680 690 700 710 560 570 580 590 600 pF1KE2 QGILENIQRNKLLFIETQDGAETSVA--LEKYQEACE-NGR--GAILLSVARGKVSEGID :. .:.. : ...: : : .:. :. : .: . .:. ::.:..: :::::::.: XP_011 TGLWHNLELVKTVIVEPQGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLD 720 730 740 750 760 770 610 620 630 640 650 660 pF1KE2 FVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRE----NDFLTFDAMRHAAQCVG : .:::: .:.:. ... .. . .: . ..: .. ..:.: : .: XP_011 FSDDNARAVITIGIPFPNVKDLQVELKRQYNDHHSKLRGLLPGRQWYEIQAYRALNQALG 780 790 800 810 820 830 670 680 690 700 710 720 pF1KE2 RAIRGKTDYGLMVFADKRFARGDKR--GKLPRWIQEHLTDANLNLTVDEGVQVAKYFLRQ : :: ..:.: ....: :: . .: . : .:..... XP_011 RCIRHRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKKHQK 840 850 860 870 880 890 730 740 750 760 pF1KE2 MAQPFHREDQLGLSLLSLEQLESEETLQRIEQIAQQL XP_011 VLNVSIKDRTNIQDNESTLEVTSLKYSTSPYLLEAASHLSPENFVEDEAKICVQELQCPK 900 910 920 930 940 950 >>NP_116575 (OMIM: 608833,615190,616373) regulator of te (1243 aa) initn: 790 init1: 154 opt: 532 Z-score: 611.1 bits: 124.5 E(85289): 2.7e-27 Smith-Waterman score: 688; 25.4% identity (52.7% similar) in 792 aa overlap (18-730:18-786) 10 20 30 40 50 pF1KE2 MKLNVDGLLVYFPYDYIYPEQFSYMRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAY- : : :: .. . :. : .:.:: :.:::::. :: .:. NP_116 MPKIVLNGVTVDFPFQPYKCQQEYMTKVLECLQQKVNGILESPTGTGKTLCLLCTTLAWR 10 20 30 40 50 60 60 70 80 pF1KE2 -------------QRA----YP---------------------LEVTKLIYCSRTVPEIE .:: .: .. :.:: ::: .. NP_116 EHLRDGISARKIAERAQGELFPDRALSSWGNAAAAAGDPIACYTDIPKIIYASRTHSQLT 70 80 90 100 110 120 90 100 110 120 pF1KE2 KVIEELRKLLNFYEKQEGEKLPFLGLA----------------LSSRKNLCIHPEVTPLR .::.:::. . :... : : : :.::..::::::: . NP_116 QVINELRN--TSYRSRCRATLWVLETAPPRPTVLSPTRPKVCVLGSREQLCIHPEVKKQE 130 140 150 160 170 130 140 150 160 170 180 pF1KE2 FGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDLKALGR .. :.. .:: :. :.::.. . .. : : . : ...:: : NP_116 SNHLQIHLCRKKVAS--RS----------CHFYNNVEEKSLEQELASPILDIEDLVKSGS 180 190 200 210 220 190 200 210 220 230 240 pF1KE2 RQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCID .. :::.:.: .:... . :.:::: : . .: . .::.::::::....: . NP_116 KHRVCPYYLSRNLKQQADIIFMPYNYLLDAKSRRAHNIDL-KGTVVIFDEAHNVEKMCEE 230 240 250 260 270 280 250 260 270 280 290 300 pF1KE2 SMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHL : : .:: . : .. . . . . : . . :: . : :.: NP_116 SASFDLTPHDLASGLDVIDQVLEEQTKAAQQGEPHPEFSADSPSPGL---NMELEDIAKL 290 300 310 320 330 340 310 320 330 340 350 360 pF1KE2 ANPVLPNEVLQEAV--PGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQ .: : .:: ::. . . ... .:. .. .... . .: ... :: NP_116 KMILLRLEGAIDAVELPGDDSGVTKPGSYIFELFAEAQITFQTKGCILDSLDQIIQHLAG 350 360 370 380 390 400 370 380 390 400 410 pF1KE2 RVCIQRKPLRFCAERLRSLLHTLEITDLADFSP-----LTLLANFATLVSTYAKGFTIII :. . . . ..: .... . .: .. :: : : .. . . : : NP_116 RAGVFTNTAGL--QKLADIIQIVFSVDPSEGSPGSPAGLGALQSYKVHIHPDA-GHRRTA 410 420 430 440 450 420 430 440 450 460 470 pF1KE2 EPFDDRTPTIA---NPILHFSCMDASLAIKPVFER-FQSVIITSGTLSPLDIYPKILDF- . : . : : . .: . :.. . ... . .. .:.:.:::::.:.. . ... NP_116 QRSDAWSTTAARKRGKVLSYWCFSPGHSMHELVRQGVRSLILTSGTLAPVSSFALEMQIP 460 470 480 490 500 510 480 490 500 510 520 530 pF1KE2 HPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPD :: . . . . . .. :: : . .:: :. : . . . :. : ... ::: NP_116 FPVCLEN-PHIIDKHQIWVGVVPRGPDGAQLSSAFDRRFSEECLSSLGKALGNIARVVPY 520 530 540 550 560 570 540 550 560 570 580 590 pF1KE2 GIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQE--ACENG :.. :: :: ::... : . . .... : ::.: .. . : .. : : .. NP_116 GLLIFFPSYPVMEKSLEFWRARDLARKMEALKPLFVEPRSKGSFSETISAYYARVAAPGS 580 590 600 610 620 630 600 610 620 630 640 pF1KE2 RGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRD--------- :: .:.: :::.:::.:: ::.::. :.:: .. . ....: . NP_116 TGATFLAVCRGKASEGLDFSDTNGRGVIVTGLPYPPRMDPRVVLKMQFLDEMKGQGGAGG 640 650 660 670 680 690 650 660 670 680 690 700 pF1KE2 QFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHL- :: . ... .: : . : .::.:: . ::: . . :.::: .: :..:: :.. :. NP_116 QF-LSGQEWYRQQASRAVNQAIGRVIRHRQDYGAVFLCDHRFAFADARAQLPSWVRPHVR 700 710 720 730 740 750 710 720 730 740 750 760 pF1KE2 TDANLNLTVDEGVQVAKYFLRQMAQPFHREDQLGLSLLSLEQLESEETLQRIEQIAQQL . :.. .. . .: . : : : : NP_116 VYDNFGHVIRDVAQFFRVAERTMPAPAPRATAPSVRGEDAVSEAKSPGPFFSTRKAKSLD 760 770 780 790 800 810 >>NP_057518 (OMIM: 608833,615190,616373) regulator of te (1219 aa) initn: 790 init1: 154 opt: 517 Z-score: 593.9 bits: 121.3 E(85289): 2.4e-26 Smith-Waterman score: 729; 25.9% identity (53.7% similar) in 792 aa overlap (2-730:3-762) 10 20 30 40 50 pF1KE2 MKLNVDGLLVYFPYDYIYPEQFSYMRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAY :. ..:. : ::.. : : :: .. . :. : .:.:: :.:::::. :: .:. NP_057 MPKIVLNGVTVDFPFQP-YKCQQEYMTKVLECLQQKVNGILESPTGTGKTLCLLCTTLAW 10 20 30 40 50 60 70 80 pF1KE2 --------------QRA----YP---------------------LEVTKLIYCSRTVPEI .:: .: .. :.:: ::: .. NP_057 REHLRDGISARKIAERAQGELFPDRALSSWGNAAAAAGDPIACYTDIPKIIYASRTHSQL 60 70 80 90 100 110 90 100 110 120 130 140 pF1KE2 EKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTAS .::.:::. . :. :. :: ::..::::::: . .. :.. .:: NP_057 TQVINELRN--TSYRP----KVCVLG----SREQLCIHPEVKKQESNHLQIHLCRKKVAS 120 130 140 150 160 150 160 170 180 190 200 pF1KE2 YVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDLKALGRRQGWCPYFLARYSIL :. :.::.. . .. : : . : ...:: : .. :::.:.: NP_057 --RS----------CHFYNNVEEKSLEQELASPILDIEDLVKSGSKHRVCPYYLSRNLKQ 170 180 190 200 210 210 220 230 240 250 260 pF1KE2 HANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQ .:... . :.:::: : . .: . .::.::::::....: .: : .:: . : NP_057 QADIIFMPYNYLLDAKSRRAHNIDL-KGTVVIFDEAHNVEKMCEESASFDLTPHDLASGL 220 230 240 250 260 270 270 280 290 300 310 pF1KE2 GNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPNEVLQEAV- .. . . . . : . . :: . : :.: .: : .:: NP_057 DVIDQVLEEQTKAAQQGEPHPEFSADSPSPGL---NMELEDIAKLKMILLRLEGAIDAVE 280 290 300 310 320 330 320 330 340 350 360 370 pF1KE2 -PGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAER ::. . . ... .:. .. .... . .: ... :: :. . . . .. NP_057 LPGDDSGVTKPGSYIFELFAEAQITFQTKGCILDSLDQIIQHLAGRAGVFTNTAGL--QK 340 350 360 370 380 390 380 390 400 410 420 430 pF1KE2 LRSLLHTLEITDLADFSP-----LTLLANFATLVSTYAKGFTIIIEPFDDRTPTIA---N : .... . .: .. :: : : .. . . : : . : . : : . NP_057 LADIIQIVFSVDPSEGSPGSPAGLGALQSYKVHIHPDA-GHRRTAQRSDAWSTTAARKRG 400 410 420 430 440 450 440 450 460 470 480 pF1KE2 PILHFSCMDASLAIKPVFER-FQSVIITSGTLSPLDIYPKILDF-HPVTMATFTMTLARV .: . :.. . ... . .. .:.:.:::::.:.. . ... :: . . . . NP_057 KVLSYWCFSPGHSMHELVRQGVRSLILTSGTLAPVSSFALEMQIPFPVCLEN-PHIIDKH 460 470 480 490 500 490 500 510 520 530 540 pF1KE2 CLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMEST . .. :: : . .:: :. : . . . :. : ... ::: :.. :: :: ::.. NP_057 QIWVGVVPRGPDGAQLSSAFDRRFSEECLSSLGKALGNIARVVPYGLLIFFPSYPVMEKS 510 520 530 540 550 560 550 560 570 580 590 600 pF1KE2 VASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQE--ACENGRGAILLSVARGKVSE . : . . .... : ::.: .. . : .. : : .. :: .:.: :::.:: NP_057 LEFWRARDLARKMEALKPLFVEPRSKGSFSETISAYYARVAAPGSTGATFLAVCRGKASE 570 580 590 600 610 620 610 620 630 640 650 pF1KE2 GIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRD---------QFQIRENDFLTFDAM :.:: ::.::. :.:: .. . ....: . :: . ... .: NP_057 GLDFSDTNGRGVIVTGLPYPPRMDPRVVLKMQFLDEMKGQGGAGGQF-LSGQEWYRQQAS 630 640 650 660 670 680 660 670 680 690 700 710 pF1KE2 RHAAQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHL-TDANLNLTVDEGVQV : . : .::.:: . ::: . . :.::: .: :..:: :.. :. . :.. .. . .: NP_057 RAVNQAIGRVIRHRQDYGAVFLCDHRFAFADARAQLPSWVRPHVRVYDNFGHVIRDVAQF 690 700 710 720 730 740 720 730 740 750 760 pF1KE2 AKYFLRQMAQPFHREDQLGLSLLSLEQLESEETLQRIEQIAQQL . : : : : NP_057 FRVAERTMPAPAPRATAPSVRGEDAVSEAKSPGPFFSTRKAKSLDLHVPSLKQRSSGSPA 750 760 770 780 790 800 >>NP_001269938 (OMIM: 608833,615190,616373) regulator of (1300 aa) initn: 790 init1: 154 opt: 517 Z-score: 593.5 bits: 121.3 E(85289): 2.6e-26 Smith-Waterman score: 729; 25.9% identity (53.7% similar) in 792 aa overlap (2-730:3-762) 10 20 30 40 50 pF1KE2 MKLNVDGLLVYFPYDYIYPEQFSYMRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAY :. ..:. : ::.. : : :: .. . :. : .:.:: :.:::::. :: .:. NP_001 MPKIVLNGVTVDFPFQP-YKCQQEYMTKVLECLQQKVNGILESPTGTGKTLCLLCTTLAW 10 20 30 40 50 60 70 80 pF1KE2 --------------QRA----YP---------------------LEVTKLIYCSRTVPEI .:: .: .. :.:: ::: .. NP_001 REHLRDGISARKIAERAQGELFPDRALSSWGNAAAAAGDPIACYTDIPKIIYASRTHSQL 60 70 80 90 100 110 90 100 110 120 130 140 pF1KE2 EKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTAS .::.:::. . :. :. :: ::..::::::: . .. :.. .:: NP_001 TQVINELRN--TSYRP----KVCVLG----SREQLCIHPEVKKQESNHLQIHLCRKKVAS 120 130 140 150 160 150 160 170 180 190 200 pF1KE2 YVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDLKALGRRQGWCPYFLARYSIL :. :.::.. . .. : : . : ...:: : .. :::.:.: NP_001 --RS----------CHFYNNVEEKSLEQELASPILDIEDLVKSGSKHRVCPYYLSRNLKQ 170 180 190 200 210 210 220 230 240 250 260 pF1KE2 HANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQ .:... . :.:::: : . .: . .::.::::::....: .: : .:: . : NP_001 QADIIFMPYNYLLDAKSRRAHNIDL-KGTVVIFDEAHNVEKMCEESASFDLTPHDLASGL 220 230 240 250 260 270 270 280 290 300 310 pF1KE2 GNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPNEVLQEAV- .. . . . . : . . :: . : :.: .: : .:: NP_001 DVIDQVLEEQTKAAQQGEPHPEFSADSPSPGL---NMELEDIAKLKMILLRLEGAIDAVE 280 290 300 310 320 330 320 330 340 350 360 370 pF1KE2 -PGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAER ::. . . ... .:. .. .... . .: ... :: :. . . . .. NP_001 LPGDDSGVTKPGSYIFELFAEAQITFQTKGCILDSLDQIIQHLAGRAGVFTNTAGL--QK 340 350 360 370 380 390 380 390 400 410 420 430 pF1KE2 LRSLLHTLEITDLADFSP-----LTLLANFATLVSTYAKGFTIIIEPFDDRTPTIA---N : .... . .: .. :: : : .. . . : : . : . : : . NP_001 LADIIQIVFSVDPSEGSPGSPAGLGALQSYKVHIHPDA-GHRRTAQRSDAWSTTAARKRG 400 410 420 430 440 450 440 450 460 470 480 pF1KE2 PILHFSCMDASLAIKPVFER-FQSVIITSGTLSPLDIYPKILDF-HPVTMATFTMTLARV .: . :.. . ... . .. .:.:.:::::.:.. . ... :: . . . . NP_001 KVLSYWCFSPGHSMHELVRQGVRSLILTSGTLAPVSSFALEMQIPFPVCLEN-PHIIDKH 460 470 480 490 500 490 500 510 520 530 540 pF1KE2 CLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMEST . .. :: : . .:: :. : . . . :. : ... ::: :.. :: :: ::.. NP_001 QIWVGVVPRGPDGAQLSSAFDRRFSEECLSSLGKALGNIARVVPYGLLIFFPSYPVMEKS 510 520 530 540 550 560 550 560 570 580 590 600 pF1KE2 VASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQE--ACENGRGAILLSVARGKVSE . : . . .... : ::.: .. . : .. : : .. :: .:.: :::.:: NP_001 LEFWRARDLARKMEALKPLFVEPRSKGSFSETISAYYARVAAPGSTGATFLAVCRGKASE 570 580 590 600 610 620 610 620 630 640 650 pF1KE2 GIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRD---------QFQIRENDFLTFDAM :.:: ::.::. :.:: .. . ....: . :: . ... .: NP_001 GLDFSDTNGRGVIVTGLPYPPRMDPRVVLKMQFLDEMKGQGGAGGQF-LSGQEWYRQQAS 630 640 650 660 670 680 660 670 680 690 700 710 pF1KE2 RHAAQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHL-TDANLNLTVDEGVQV : . : .::.:: . ::: . . :.::: .: :..:: :.. :. . :.. .. . .: NP_001 RAVNQAIGRVIRHRQDYGAVFLCDHRFAFADARAQLPSWVRPHVRVYDNFGHVIRDVAQF 690 700 710 720 730 740 720 730 740 750 760 pF1KE2 AKYFLRQMAQPFHREDQLGLSLLSLEQLESEETLQRIEQIAQQL . : : : : NP_001 FRVAERTMPAPAPRATAPSVRGEDAVSEAKSPGPFFSTRKAKSLDLHVPSLKQRSSGSPA 750 760 770 780 790 800 760 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 12:10:30 2016 done: Sun Nov 6 12:10:32 2016 Total Scan time: 11.680 Total Display time: 0.220 Function used was FASTA [36.3.4 Apr, 2011]