Result of FASTA (omim) for pFN21AE2250
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE2250, 170 aa
  1>>>pF1KE2250 170 - 170 aa - 170 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 4.3669+/-0.000307; mu= 17.3659+/- 0.019
 mean_var=55.8097+/-11.185, 0's: 0 Z-trim(116.3): 112  B-trim: 58 in 1/51
 Lambda= 0.171680
 statistics sampled from 27158 (27284) to 27158 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.73), E-opt: 0.2 (0.32), width:  16
 Scan time:  5.530

The best scores are:                                      opt bits E(85289)
NP_003333 (OMIM: 601569) ubiquitin-conjugating enz ( 170) 1169 297.0 9.8e-81
NP_060281 (OMIM: 612506) ubiquitin-conjugating enz ( 238)  610 158.6   6e-39
NP_003334 (OMIM: 603124) ubiquitin-conjugating enz ( 165)  587 152.8 2.4e-37
XP_006723015 (OMIM: 116948) PREDICTED: ubiquitin-c ( 179)  581 151.4 7.1e-37
NP_004350 (OMIM: 116948) ubiquitin-conjugating enz ( 236)  579 151.0 1.2e-36
XP_005259747 (OMIM: 116948) PREDICTED: ubiquitin-c ( 269)  576 150.3 2.3e-36
NP_872630 (OMIM: 603124) ubiquitin-conjugating enz ( 137)  539 140.9 7.8e-34
XP_016883958 (OMIM: 603124) PREDICTED: ubiquitin-c ( 137)  539 140.9 7.8e-34
XP_011516251 (OMIM: 612506) PREDICTED: ubiquitin-c ( 193)  493 129.6 2.7e-30
NP_001189418 (OMIM: 603124) ubiquitin-conjugating  (  95)  360 96.4 1.3e-20
NP_003329 (OMIM: 602961) ubiquitin-conjugating enz ( 147)  318 86.2 2.5e-17
NP_871622 (OMIM: 602963) ubiquitin-conjugating enz ( 149)  301 81.9 4.6e-16
NP_871620 (OMIM: 602963) ubiquitin-conjugating enz ( 147)  298 81.2 7.7e-16
NP_871619 (OMIM: 602963) ubiquitin-conjugating enz ( 147)  298 81.2 7.7e-16
NP_871617 (OMIM: 602963) ubiquitin-conjugating enz ( 147)  298 81.2 7.7e-16
NP_003331 (OMIM: 602963) ubiquitin-conjugating enz ( 147)  298 81.2 7.7e-16
NP_871618 (OMIM: 602963) ubiquitin-conjugating enz ( 147)  298 81.2 7.7e-16
NP_871616 (OMIM: 602963) ubiquitin-conjugating enz ( 147)  298 81.2 7.7e-16
NP_871615 (OMIM: 602963) ubiquitin-conjugating enz ( 147)  298 81.2 7.7e-16
NP_871621 (OMIM: 602963) ubiquitin-conjugating enz ( 148)  298 81.2 7.7e-16
NP_003330 (OMIM: 602962) ubiquitin-conjugating enz ( 147)  297 80.9 9.1e-16
XP_016865309 (OMIM: 602962) PREDICTED: ubiquitin-c ( 173)  292 79.8 2.4e-15
NP_001265484 (OMIM: 604151) ubiquitin-conjugating  ( 207)  281 77.1 1.8e-14
NP_006348 (OMIM: 604151) ubiquitin-conjugating enz ( 207)  281 77.1 1.8e-14
NP_001265483 (OMIM: 604151) ubiquitin-conjugating  ( 207)  281 77.1 1.8e-14
XP_005246301 (OMIM: 604151) PREDICTED: ubiquitin-c ( 207)  281 77.1 1.8e-14
NP_872619 (OMIM: 604151) ubiquitin-conjugating enz ( 207)  281 77.1 1.8e-14
XP_005265490 (OMIM: 602163) PREDICTED: ubiquitin-c ( 189)  280 76.8   2e-14
NP_689866 (OMIM: 602163) ubiquitin-conjugating enz ( 201)  280 76.9 2.1e-14
XP_005265489 (OMIM: 602163) PREDICTED: ubiquitin-c ( 201)  280 76.9 2.1e-14
NP_003332 (OMIM: 602916) ubiquitin-conjugating enz ( 193)  270 74.4 1.2e-13
NP_001189405 (OMIM: 602916) ubiquitin-conjugating  ( 160)  266 73.3   2e-13
XP_005265488 (OMIM: 602916) PREDICTED: ubiquitin-c ( 167)  266 73.3 2.1e-13
XP_005251553 (OMIM: 612506) PREDICTED: ubiquitin-c ( 209)  262 72.4 4.8e-13
NP_054895 (OMIM: 610538,616435) ubiquitin-conjugat ( 197)  256 70.9 1.3e-12
NP_001287724 (OMIM: 602963) ubiquitin-conjugating  ( 118)  252 69.7 1.8e-12
NP_862821 (OMIM: 602962) ubiquitin-conjugating enz ( 118)  252 69.7 1.8e-12
XP_016864073 (OMIM: 602963) PREDICTED: ubiquitin-c ( 118)  252 69.7 1.8e-12
NP_003339 (OMIM: 603679) ubiquitin-conjugating enz ( 152)  253 70.1 1.8e-12
XP_016884424 (OMIM: 603721) PREDICTED: ubiquitin-c ( 121)  249 69.0   3e-12
NP_003338 (OMIM: 603721) ubiquitin-conjugating enz ( 154)  249 69.1 3.6e-12
NP_001243284 (OMIM: 603721) ubiquitin-conjugating  ( 212)  243 67.7 1.3e-11
XP_016872098 (OMIM: 602961) PREDICTED: ubiquitin-c ( 110)  239 66.5 1.6e-11
NP_872607 (OMIM: 602916) ubiquitin-conjugating enz ( 176)  241 67.1 1.6e-11
NP_003327 (OMIM: 300860,312180) ubiquitin-conjugat ( 152)  239 66.6   2e-11
XP_011525054 (OMIM: 610309) PREDICTED: ubiquitin-c ( 162)  238 66.4 2.5e-11
NP_003328 (OMIM: 179095) ubiquitin-conjugating enz ( 152)  237 66.1 2.8e-11
NP_001104582 (OMIM: 602846) ubiquitin-conjugating  ( 157)  237 66.1 2.9e-11
NP_055316 (OMIM: 610309) ubiquitin-conjugating enz ( 222)  238 66.5 3.1e-11
NP_075567 (OMIM: 611362) ubiquitin-conjugating enz ( 354)  240 67.1 3.1e-11


>>NP_003333 (OMIM: 601569) ubiquitin-conjugating enzyme   (170 aa)
 initn: 1169 init1: 1169 opt: 1169  Z-score: 1570.4  bits: 297.0 E(85289): 9.8e-81
Smith-Waterman score: 1169; 100.0% identity (100.0% similar) in 170 aa overlap (1-170:1-170)

               10        20        30        40        50        60
pF1KE2 MTELQSALLLRRQLAELNKNPVEGFSAGLIDDNDLYRWEVLIIGPPDTLYEGGVFKAHLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MTELQSALLLRRQLAELNKNPVEGFSAGLIDDNDLYRWEVLIIGPPDTLYEGGVFKAHLT
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE2 FPKDYPLRPPKMKFITEIWHPNVDKNGDVCISILHEPGEDKYGYEKPEERWLPIHTVETI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 FPKDYPLRPPKMKFITEIWHPNVDKNGDVCISILHEPGEDKYGYEKPEERWLPIHTVETI
               70        80        90       100       110       120

              130       140       150       160       170
pF1KE2 MISVISMLADPNGDSPANVDAAKEWREDRNGEFKRKVARCVRKSQETAFE
       ::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MISVISMLADPNGDSPANVDAAKEWREDRNGEFKRKVARCVRKSQETAFE
              130       140       150       160       170

>>NP_060281 (OMIM: 612506) ubiquitin-conjugating enzyme   (238 aa)
 initn: 596 init1: 556 opt: 610  Z-score: 820.2  bits: 158.6 E(85289): 6e-39
Smith-Waterman score: 610; 53.0% identity (77.1% similar) in 166 aa overlap (1-163:6-167)

                    10        20        30        40        50     
pF1KE2      MTELQSALLLRRQLAELNKNPVEGFSAGLIDDNDLYRWEVLIIGPPDTLYEGGVF
            ::  :.::.:  .:  :...:::::   :.:..::: ::: :.:::.:::::: :
NP_060 MAQQQMTSSQKALML--ELKSLQEEPVEGFRITLVDESDLYNWEVAIFGPPNTLYEGGYF
               10          20        30        40        50        

          60        70        80        90       100       110     
pF1KE2 KAHLTFPKDYPLRPPKMKFITEIWHPNVDKNGDVCISILHEPGEDKYGYEKPEERWLPIH
       :::. :: :::  :: ..:.:..::::. .:::::::::: : .:  . : : ::: : .
NP_060 KAHIKFPIDYPYSPPTFRFLTKMWHPNIYENGDVCISILHPPVDDPQSGELPSERWNPTQ
       60        70        80        90       100       110        

         120       130       140          150       160       170  
pF1KE2 TVETIMISVISMLADPNGDSPANVDAA---KEWREDRNGEFKRKVARCVRKSQETAFE  
       .:.::..::::.: .::  :::::::.   ..::.... .  .. :. .::         
NP_060 NVRTILLSVISLLNEPNTFSPANVDASVMFRKWRDSKGKD--KEYAEIIRKQVSATKAEA
      120       130       140       150         160       170      

NP_060 EKDGVKVPTTLAEYCIKTKVPSNDNSSDLLYDDLYDDDIDDEDEEEEDADCYDDDDSGNE
        180       190       200       210       220       230      

>>NP_003334 (OMIM: 603124) ubiquitin-conjugating enzyme   (165 aa)
 initn: 568 init1: 568 opt: 587  Z-score: 791.5  bits: 152.8 E(85289): 2.4e-37
Smith-Waterman score: 587; 53.2% identity (78.5% similar) in 158 aa overlap (10-164:6-162)

               10           20        30        40        50       
pF1KE2 MTELQSALLLRRQLAE---LNKNPVEGFSAGLIDDNDLYRWEVLIIGPPDTLYEGGVFKA
                :.: .::   :. :: ::. :: ........::.::.:: :: .: ::: :
NP_003     MAGTALKRLMAEYKQLTLNPPEGIVAGPMNEENFFEWEALIMGPEDTCFEFGVFPA
                   10        20        30        40        50      

        60        70        80        90       100       110       
pF1KE2 HLTFPKDYPLRPPKMKFITEIWHPNVDKNGDVCISILHEPGEDKYGYEKPEERWLPIHTV
        :.:: :::: ::::.:  :..:::.  .: ::::::: ::.: .:::.  ::: :...:
NP_003 ILSFPLDYPLSPPKMRFTCEMFHPNIYPDGRVCISILHAPGDDPMGYESSAERWSPVQSV
         60        70        80        90       100       110      

       120       130       140       150       160       170
pF1KE2 ETIMISVISMLADPNGDSPANVDAAKEWREDRNGEFKRKVARCVRKSQETAFE
       : :..::.::::.:: .: :::::.: ::.::. .: . . . :.::      
NP_003 EKILLSVVSMLAEPNDESGANVDASKMWRDDRE-QFYKIAKQIVQKSLGL   
        120       130       140        150       160        

>>XP_006723015 (OMIM: 116948) PREDICTED: ubiquitin-conju  (179 aa)
 initn: 576 init1: 536 opt: 581  Z-score: 783.0  bits: 151.4 E(85289): 7.1e-37
Smith-Waterman score: 581; 52.1% identity (77.3% similar) in 163 aa overlap (5-164:10-168)

                    10        20        30        40        50     
pF1KE2      MTELQSALLLRRQLAELNKNPVEGFSAGLIDDNDLYRWEVLIIGPPDTLYEGGVF
                :.::::  .:  :...::::: . :.:..::: ::: :.:::.: :::: :
XP_006 MARPLVPSSQKALLL--ELKGLQEEPVEGFRVTLVDEGDLYNWEVAIFGPPNTYYEGGYF
               10          20        30        40        50        

          60        70        80        90       100       110     
pF1KE2 KAHLTFPKDYPLRPPKMKFITEIWHPNVDKNGDVCISILHEPGEDKYGYEKPEERWLPIH
       ::.: :: :::  :: ..:.:..::::. ..::::::::: : .:  . : : ::: : .
XP_006 KARLKFPIDYPYSPPAFRFLTKMWHPNIYETGDVCISILHPPVDDPQSGELPSERWNPTQ
       60        70        80        90       100       110        

         120       130       140          150       160       170  
pF1KE2 TVETIMISVISMLADPNGDSPANVDAA---KEWREDRNGEFKRKVARCVRKSQETAFE  
       .:.::..::::.: .::  :::::::.   ..:.:... .  :. .  .:.:        
XP_006 NVRTILLSVISLLNEPNTFSPANVDASVMYRKWKESKGKD--REYTDIIRRSWGPRWTRS
      120       130       140       150         160       170      

XP_006 VTA
          

>>NP_004350 (OMIM: 116948) ubiquitin-conjugating enzyme   (236 aa)
 initn: 576 init1: 536 opt: 579  Z-score: 778.7  bits: 151.0 E(85289): 1.2e-36
Smith-Waterman score: 579; 52.5% identity (77.2% similar) in 162 aa overlap (5-163:10-167)

                    10        20        30        40        50     
pF1KE2      MTELQSALLLRRQLAELNKNPVEGFSAGLIDDNDLYRWEVLIIGPPDTLYEGGVF
                :.::::  .:  :...::::: . :.:..::: ::: :.:::.: :::: :
NP_004 MARPLVPSSQKALLL--ELKGLQEEPVEGFRVTLVDEGDLYNWEVAIFGPPNTYYEGGYF
               10          20        30        40        50        

          60        70        80        90       100       110     
pF1KE2 KAHLTFPKDYPLRPPKMKFITEIWHPNVDKNGDVCISILHEPGEDKYGYEKPEERWLPIH
       ::.: :: :::  :: ..:.:..::::. ..::::::::: : .:  . : : ::: : .
NP_004 KARLKFPIDYPYSPPAFRFLTKMWHPNIYETGDVCISILHPPVDDPQSGELPSERWNPTQ
       60        70        80        90       100       110        

         120       130       140          150       160       170  
pF1KE2 TVETIMISVISMLADPNGDSPANVDAA---KEWREDRNGEFKRKVARCVRKSQETAFE  
       .:.::..::::.: .::  :::::::.   ..:.:... .  :. .  .::         
NP_004 NVRTILLSVISLLNEPNTFSPANVDASVMYRKWKESKGKD--REYTDIIRKQVLGTKVDA
      120       130       140       150         160       170      

NP_004 ERDGVKVPTTLAEYCVKTKAPAPDEGSDLFYDDYYEDGEVEEEADSCFGDDEDDSGTEES
        180       190       200       210       220       230      

>>XP_005259747 (OMIM: 116948) PREDICTED: ubiquitin-conju  (269 aa)
 initn: 560 init1: 560 opt: 576  Z-score: 774.0  bits: 150.3 E(85289): 2.3e-36
Smith-Waterman score: 576; 52.1% identity (77.0% similar) in 165 aa overlap (5-166:10-169)

                    10        20        30        40        50     
pF1KE2      MTELQSALLLRRQLAELNKNPVEGFSAGLIDDNDLYRWEVLIIGPPDTLYEGGVF
                :.::::  .:  :...::::: . :.:..::: ::: :.:::.: :::: :
XP_005 MARPLVPSSQKALLL--ELKGLQEEPVEGFRVTLVDEGDLYNWEVAIFGPPNTYYEGGYF
               10          20        30        40        50        

          60        70        80        90       100       110     
pF1KE2 KAHLTFPKDYPLRPPKMKFITEIWHPNVDKNGDVCISILHEPGEDKYGYEKPEERWLPIH
       ::.: :: :::  :: ..:.:..::::. ..::::::::: : .:  . : : ::: : .
XP_005 KARLKFPIDYPYSPPAFRFLTKMWHPNIYETGDVCISILHPPVDDPQSGELPSERWNPTQ
       60        70        80        90       100       110        

         120       130       140          150       160       170  
pF1KE2 TVETIMISVISMLADPNGDSPANVDAA---KEWREDRNGEFKRKVARCVRKSQETAFE  
       .:.::..::::.: .::  :::::::.   ..:.:... .  :. .  .: .::      
XP_005 NVRTILLSVISLLNEPNTFSPANVDASVMYRKWKESKGKD--REYTDIIR-TQEHPGHLP
      120       130       140       150         160        170     

XP_005 SCTRWYLVSWGHLGAASWCWAVSALSSHGGRAPCGLLGSGLQAPAGLWRSQGSCPGRPSG
         180       190       200       210       220       230     

>>NP_872630 (OMIM: 603124) ubiquitin-conjugating enzyme   (137 aa)
 initn: 528 init1: 528 opt: 539  Z-score: 728.4  bits: 140.9 E(85289): 7.8e-34
Smith-Waterman score: 539; 54.1% identity (80.7% similar) in 135 aa overlap (30-164:1-134)

               10        20        30        40        50        60
pF1KE2 MTELQSALLLRRQLAELNKNPVEGFSAGLIDDNDLYRWEVLIIGPPDTLYEGGVFKAHLT
                                    ........::.::.:: :: .: ::: : :.
NP_872                              MNEENFFEWEALIMGPEDTCFEFGVFPAILS
                                            10        20        30 

               70        80        90       100       110       120
pF1KE2 FPKDYPLRPPKMKFITEIWHPNVDKNGDVCISILHEPGEDKYGYEKPEERWLPIHTVETI
       :: :::: ::::.:  :..:::.  .: ::::::: ::.: .:::.  ::: :...:: :
NP_872 FPLDYPLSPPKMRFTCEMFHPNIYPDGRVCISILHAPGDDPMGYESSAERWSPVQSVEKI
              40        50        60        70        80        90 

              130       140       150       160       170
pF1KE2 MISVISMLADPNGDSPANVDAAKEWREDRNGEFKRKVARCVRKSQETAFE
       ..::.::::.:: .: :::::.: ::.::. .: . . . :.::      
NP_872 LLSVVSMLAEPNDESGANVDASKMWRDDRE-QFYKIAKQIVQKSLGL   
             100       110       120        130          

>>XP_016883958 (OMIM: 603124) PREDICTED: ubiquitin-conju  (137 aa)
 initn: 528 init1: 528 opt: 539  Z-score: 728.4  bits: 140.9 E(85289): 7.8e-34
Smith-Waterman score: 539; 54.1% identity (80.7% similar) in 135 aa overlap (30-164:1-134)

               10        20        30        40        50        60
pF1KE2 MTELQSALLLRRQLAELNKNPVEGFSAGLIDDNDLYRWEVLIIGPPDTLYEGGVFKAHLT
                                    ........::.::.:: :: .: ::: : :.
XP_016                              MNEENFFEWEALIMGPEDTCFEFGVFPAILS
                                            10        20        30 

               70        80        90       100       110       120
pF1KE2 FPKDYPLRPPKMKFITEIWHPNVDKNGDVCISILHEPGEDKYGYEKPEERWLPIHTVETI
       :: :::: ::::.:  :..:::.  .: ::::::: ::.: .:::.  ::: :...:: :
XP_016 FPLDYPLSPPKMRFTCEMFHPNIYPDGRVCISILHAPGDDPMGYESSAERWSPVQSVEKI
              40        50        60        70        80        90 

              130       140       150       160       170
pF1KE2 MISVISMLADPNGDSPANVDAAKEWREDRNGEFKRKVARCVRKSQETAFE
       ..::.::::.:: .: :::::.: ::.::. .: . . . :.::      
XP_016 LLSVVSMLAEPNDESGANVDASKMWRDDRE-QFYKIAKQIVQKSLGL   
             100       110       120        130          

>>XP_011516251 (OMIM: 612506) PREDICTED: ubiquitin-conju  (193 aa)
 initn: 495 init1: 456 opt: 493  Z-score: 664.8  bits: 129.6 E(85289): 2.7e-30
Smith-Waterman score: 493; 52.6% identity (75.2% similar) in 133 aa overlap (1-133:6-135)

                    10        20        30        40        50     
pF1KE2      MTELQSALLLRRQLAELNKNPVEGFSAGLIDDNDLYRWEVLIIGPPDTLYEGGVF
            ::  :.::.:  .:  :...:::::   :.:..::: ::: :.:::.:::::: :
XP_011 MAQQQMTSSQKALML--ELKSLQEEPVEGFRITLVDESDLYNWEVAIFGPPNTLYEGGYF
               10          20        30        40        50        

          60        70        80        90       100       110     
pF1KE2 KAHLTFPKDYPLRPPKMKFITEIWHPNVDKNGDVCISILHEPGEDKYGYEKPEERWLPIH
       :::. :: :::  :: ..:.:..::::. .:::::::::: : .:  . : : ::: : .
XP_011 KAHIKFPIDYPYSPPTFRFLTKMWHPNIYENGDVCISILHPPVDDPQSGELPSERWNPTQ
       60        70        80        90       100       110        

         120       130       140       150       160       170     
pF1KE2 TVETIMISVISMLADPNGDSPANVDAAKEWREDRNGEFKRKVARCVRKSQETAFE     
       .:.  ..:. .  :. .:                                          
XP_011 NVRK-QVSATKAEAEKDGVKVPTTLAEYCIKTKVPSNDNSSDLLYDDLYDDDIDDEDEEE
      120        130       140       150       160       170       

>>NP_001189418 (OMIM: 603124) ubiquitin-conjugating enzy  (95 aa)
 initn: 349 init1: 349 opt: 360  Z-score: 490.9  bits: 96.4 E(85289): 1.3e-20
Smith-Waterman score: 360; 53.8% identity (79.6% similar) in 93 aa overlap (72-164:1-92)

              50        60        70        80        90       100 
pF1KE2 IIGPPDTLYEGGVFKAHLTFPKDYPLRPPKMKFITEIWHPNVDKNGDVCISILHEPGEDK
                                     :.:  :..:::.  .: ::::::: ::.: 
NP_001                               MRFTCEMFHPNIYPDGRVCISILHAPGDDP
                                             10        20        30

             110       120       130       140       150       160 
pF1KE2 YGYEKPEERWLPIHTVETIMISVISMLADPNGDSPANVDAAKEWREDRNGEFKRKVARCV
       .:::.  ::: :...:: :..::.::::.:: .: :::::.: ::.::. .: . . . :
NP_001 MGYESSAERWSPVQSVEKILLSVVSMLAEPNDESGANVDASKMWRDDRE-QFYKIAKQIV
               40        50        60        70         80         

             170
pF1KE2 RKSQETAFE
       .::      
NP_001 QKSLGL   
      90        




170 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sun Nov  6 12:17:41 2016 done: Sun Nov  6 12:17:41 2016
 Total Scan time:  5.530 Total Display time: -0.010

Function used was FASTA [36.3.4 Apr, 2011]
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