Result of FASTA (omim) for
pFN21AE1128
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1128, 165 aa
1>>>pF1KE1128 165 - 165 aa - 165 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1252+/-0.000328; mu= 13.6425+/- 0.021
mean_var=69.7179+/-14.087, 0's: 0 Z-trim(117.2): 96 B-trim: 1232 in 2/51
Lambda= 0.153604
statistics sampled from 28948 (29053) to 28948 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.732), E-opt: 0.2 (0.341), width: 16
Scan time: 5.330
The best scores are: opt bits E(85289)
NP_003334 (OMIM: 603124) ubiquitin-conjugating enz ( 165) 1138 260.5 9e-70
XP_016883958 (OMIM: 603124) PREDICTED: ubiquitin-c ( 137) 957 220.3 9.2e-58
NP_872630 (OMIM: 603124) ubiquitin-conjugating enz ( 137) 957 220.3 9.2e-58
NP_001189418 (OMIM: 603124) ubiquitin-conjugating ( 95) 651 152.4 1.8e-37
NP_003333 (OMIM: 601569) ubiquitin-conjugating enz ( 170) 587 138.4 5.2e-33
NP_060281 (OMIM: 612506) ubiquitin-conjugating enz ( 238) 516 122.8 3.7e-28
NP_004350 (OMIM: 116948) ubiquitin-conjugating enz ( 236) 504 120.1 2.3e-27
XP_006723015 (OMIM: 116948) PREDICTED: ubiquitin-c ( 179) 501 119.3 3e-27
XP_005259747 (OMIM: 116948) PREDICTED: ubiquitin-c ( 269) 497 118.6 7.6e-27
XP_011516251 (OMIM: 612506) PREDICTED: ubiquitin-c ( 193) 397 96.3 2.7e-20
NP_003328 (OMIM: 179095) ubiquitin-conjugating enz ( 152) 313 77.6 9.1e-15
NP_003327 (OMIM: 300860,312180) ubiquitin-conjugat ( 152) 307 76.3 2.3e-14
NP_003329 (OMIM: 602961) ubiquitin-conjugating enz ( 147) 302 75.2 4.8e-14
NP_003330 (OMIM: 602962) ubiquitin-conjugating enz ( 147) 298 74.3 8.9e-14
NP_871617 (OMIM: 602963) ubiquitin-conjugating enz ( 147) 297 74.1 1e-13
NP_871615 (OMIM: 602963) ubiquitin-conjugating enz ( 147) 297 74.1 1e-13
NP_871619 (OMIM: 602963) ubiquitin-conjugating enz ( 147) 297 74.1 1e-13
NP_871620 (OMIM: 602963) ubiquitin-conjugating enz ( 147) 297 74.1 1e-13
NP_871618 (OMIM: 602963) ubiquitin-conjugating enz ( 147) 297 74.1 1e-13
NP_003331 (OMIM: 602963) ubiquitin-conjugating enz ( 147) 297 74.1 1e-13
NP_871616 (OMIM: 602963) ubiquitin-conjugating enz ( 147) 297 74.1 1e-13
NP_871621 (OMIM: 602963) ubiquitin-conjugating enz ( 148) 297 74.1 1e-13
NP_871622 (OMIM: 602963) ubiquitin-conjugating enz ( 149) 279 70.1 1.7e-12
XP_016865309 (OMIM: 602962) PREDICTED: ubiquitin-c ( 173) 275 69.3 3.5e-12
XP_005251553 (OMIM: 612506) PREDICTED: ubiquitin-c ( 209) 271 68.4 7.4e-12
NP_919236 (OMIM: 601661) SUMO-conjugating enzyme U ( 158) 265 67.0 1.5e-11
NP_003336 (OMIM: 601661) SUMO-conjugating enzyme U ( 158) 265 67.0 1.5e-11
NP_919235 (OMIM: 601661) SUMO-conjugating enzyme U ( 158) 265 67.0 1.5e-11
NP_919237 (OMIM: 601661) SUMO-conjugating enzyme U ( 158) 265 67.0 1.5e-11
XP_016879129 (OMIM: 601661) PREDICTED: SUMO-conjug ( 158) 265 67.0 1.5e-11
XP_011520946 (OMIM: 601661) PREDICTED: SUMO-conjug ( 184) 265 67.1 1.7e-11
XP_011520947 (OMIM: 601661) PREDICTED: SUMO-conjug ( 184) 265 67.1 1.7e-11
XP_005255598 (OMIM: 601661) PREDICTED: SUMO-conjug ( 184) 265 67.1 1.7e-11
XP_005255597 (OMIM: 601661) PREDICTED: SUMO-conjug ( 184) 265 67.1 1.7e-11
NP_001265484 (OMIM: 604151) ubiquitin-conjugating ( 207) 260 66.0 4e-11
NP_001265483 (OMIM: 604151) ubiquitin-conjugating ( 207) 260 66.0 4e-11
NP_872619 (OMIM: 604151) ubiquitin-conjugating enz ( 207) 260 66.0 4e-11
XP_005246301 (OMIM: 604151) PREDICTED: ubiquitin-c ( 207) 260 66.0 4e-11
NP_006348 (OMIM: 604151) ubiquitin-conjugating enz ( 207) 260 66.0 4e-11
XP_005265490 (OMIM: 602163) PREDICTED: ubiquitin-c ( 189) 259 65.7 4.3e-11
XP_005265489 (OMIM: 602163) PREDICTED: ubiquitin-c ( 201) 259 65.8 4.6e-11
NP_689866 (OMIM: 602163) ubiquitin-conjugating enz ( 201) 259 65.8 4.6e-11
NP_003332 (OMIM: 602916) ubiquitin-conjugating enz ( 193) 252 64.2 1.3e-10
NP_001189405 (OMIM: 602916) ubiquitin-conjugating ( 160) 241 61.7 6e-10
XP_005265488 (OMIM: 602916) PREDICTED: ubiquitin-c ( 167) 241 61.7 6.2e-10
NP_001287724 (OMIM: 602963) ubiquitin-conjugating ( 118) 237 60.7 8.8e-10
NP_862821 (OMIM: 602962) ubiquitin-conjugating enz ( 118) 237 60.7 8.8e-10
XP_016864073 (OMIM: 602963) PREDICTED: ubiquitin-c ( 118) 237 60.7 8.8e-10
NP_003339 (OMIM: 603679) ubiquitin-conjugating enz ( 152) 238 61.0 9.2e-10
NP_075567 (OMIM: 611362) ubiquitin-conjugating enz ( 354) 240 61.7 1.3e-09
>>NP_003334 (OMIM: 603124) ubiquitin-conjugating enzyme (165 aa)
initn: 1138 init1: 1138 opt: 1138 Z-score: 1373.6 bits: 260.5 E(85289): 9e-70
Smith-Waterman score: 1138; 100.0% identity (100.0% similar) in 165 aa overlap (1-165:1-165)
10 20 30 40 50 60
pF1KE1 MAGTALKRLMAEYKQLTLNPPEGIVAGPMNEENFFEWEALIMGPEDTCFEFGVFPAILSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MAGTALKRLMAEYKQLTLNPPEGIVAGPMNEENFFEWEALIMGPEDTCFEFGVFPAILSF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 PLDYPLSPPKMRFTCEMFHPNIYPDGRVCISILHAPGDDPMGYESSAERWSPVQSVEKIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 PLDYPLSPPKMRFTCEMFHPNIYPDGRVCISILHAPGDDPMGYESSAERWSPVQSVEKIL
70 80 90 100 110 120
130 140 150 160
pF1KE1 LSVVSMLAEPNDESGANVDASKMWRDDREQFYKIAKQIVQKSLGL
:::::::::::::::::::::::::::::::::::::::::::::
NP_003 LSVVSMLAEPNDESGANVDASKMWRDDREQFYKIAKQIVQKSLGL
130 140 150 160
>>XP_016883958 (OMIM: 603124) PREDICTED: ubiquitin-conju (137 aa)
initn: 957 init1: 957 opt: 957 Z-score: 1158.0 bits: 220.3 E(85289): 9.2e-58
Smith-Waterman score: 957; 100.0% identity (100.0% similar) in 137 aa overlap (29-165:1-137)
10 20 30 40 50 60
pF1KE1 MAGTALKRLMAEYKQLTLNPPEGIVAGPMNEENFFEWEALIMGPEDTCFEFGVFPAILSF
::::::::::::::::::::::::::::::::
XP_016 MNEENFFEWEALIMGPEDTCFEFGVFPAILSF
10 20 30
70 80 90 100 110 120
pF1KE1 PLDYPLSPPKMRFTCEMFHPNIYPDGRVCISILHAPGDDPMGYESSAERWSPVQSVEKIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLDYPLSPPKMRFTCEMFHPNIYPDGRVCISILHAPGDDPMGYESSAERWSPVQSVEKIL
40 50 60 70 80 90
130 140 150 160
pF1KE1 LSVVSMLAEPNDESGANVDASKMWRDDREQFYKIAKQIVQKSLGL
:::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSVVSMLAEPNDESGANVDASKMWRDDREQFYKIAKQIVQKSLGL
100 110 120 130
>>NP_872630 (OMIM: 603124) ubiquitin-conjugating enzyme (137 aa)
initn: 957 init1: 957 opt: 957 Z-score: 1158.0 bits: 220.3 E(85289): 9.2e-58
Smith-Waterman score: 957; 100.0% identity (100.0% similar) in 137 aa overlap (29-165:1-137)
10 20 30 40 50 60
pF1KE1 MAGTALKRLMAEYKQLTLNPPEGIVAGPMNEENFFEWEALIMGPEDTCFEFGVFPAILSF
::::::::::::::::::::::::::::::::
NP_872 MNEENFFEWEALIMGPEDTCFEFGVFPAILSF
10 20 30
70 80 90 100 110 120
pF1KE1 PLDYPLSPPKMRFTCEMFHPNIYPDGRVCISILHAPGDDPMGYESSAERWSPVQSVEKIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_872 PLDYPLSPPKMRFTCEMFHPNIYPDGRVCISILHAPGDDPMGYESSAERWSPVQSVEKIL
40 50 60 70 80 90
130 140 150 160
pF1KE1 LSVVSMLAEPNDESGANVDASKMWRDDREQFYKIAKQIVQKSLGL
:::::::::::::::::::::::::::::::::::::::::::::
NP_872 LSVVSMLAEPNDESGANVDASKMWRDDREQFYKIAKQIVQKSLGL
100 110 120 130
>>NP_001189418 (OMIM: 603124) ubiquitin-conjugating enzy (95 aa)
initn: 651 init1: 651 opt: 651 Z-score: 793.8 bits: 152.4 E(85289): 1.8e-37
Smith-Waterman score: 651; 100.0% identity (100.0% similar) in 95 aa overlap (71-165:1-95)
50 60 70 80 90 100
pF1KE1 IMGPEDTCFEFGVFPAILSFPLDYPLSPPKMRFTCEMFHPNIYPDGRVCISILHAPGDDP
::::::::::::::::::::::::::::::
NP_001 MRFTCEMFHPNIYPDGRVCISILHAPGDDP
10 20 30
110 120 130 140 150 160
pF1KE1 MGYESSAERWSPVQSVEKILLSVVSMLAEPNDESGANVDASKMWRDDREQFYKIAKQIVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGYESSAERWSPVQSVEKILLSVVSMLAEPNDESGANVDASKMWRDDREQFYKIAKQIVQ
40 50 60 70 80 90
pF1KE1 KSLGL
:::::
NP_001 KSLGL
>>NP_003333 (OMIM: 601569) ubiquitin-conjugating enzyme (170 aa)
initn: 568 init1: 568 opt: 587 Z-score: 713.6 bits: 138.4 E(85289): 5.2e-33
Smith-Waterman score: 587; 53.2% identity (78.5% similar) in 158 aa overlap (6-162:10-164)
10 20 30 40 50
pF1KE1 MAGTALKRLMAEYKQLTLNPPEGIVAGPMNEENFFEWEALIMGPEDTCFEFGVFPA
:.: .:: :. :: ::. :: ........::.::.:: :: .: ::: :
NP_003 MTELQSALLLRRQLAE---LNKNPVEGFSAGLIDDNDLYRWEVLIIGPPDTLYEGGVFKA
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 ILSFPLDYPLSPPKMRFTCEMFHPNIYPDGRVCISILHAPGDDPMGYESSAERWSPVQSV
:.:: :::: ::::.: :..:::. .: ::::::: ::.: .:::. ::: :...:
NP_003 HLTFPKDYPLRPPKMKFITEIWHPNVDKNGDVCISILHEPGEDKYGYEKPEERWLPIHTV
60 70 80 90 100 110
120 130 140 150 160
pF1KE1 EKILLSVVSMLAEPNDESGANVDASKMWRDDRE-QFYKIAKQIVQKSLGL
: :..::.::::.:: .: :::::.: ::.::. .: . . . :.::
NP_003 ETIMISVISMLADPNGDSPANVDAAKEWREDRNGEFKRKVARCVRKSQETAFE
120 130 140 150 160 170
>>NP_060281 (OMIM: 612506) ubiquitin-conjugating enzyme (238 aa)
initn: 529 init1: 495 opt: 516 Z-score: 626.5 bits: 122.8 E(85289): 3.7e-28
Smith-Waterman score: 516; 50.0% identity (70.4% similar) in 162 aa overlap (4-158:8-169)
10 20 30 40 50
pF1KE1 MAGTALKRLMAEYKQLTLNPPEGIVAGPMNEENFFEWEALIMGPEDTCFEFGVFPA
.. : :: : :.: .: ::. ..: ....::. :.:: .: .: : : :
NP_060 MAQQQMTSSQKALMLELKSLQEEPVEGFRITLVDESDLYNWEVAIFGPPNTLYEGGYFKA
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 ILSFPLDYPLSPPKMRFTCEMFHPNIYPDGRVCISILHAPGDDPMGYESSAERWSPVQSV
..::.::: ::: .:: .:.::::: .: ::::::: : :::.. : .:::.:.:.:
NP_060 HIKFPIDYPYSPPTFRFLTKMWHPNIYENGDVCISILHPPVDDPQSGELPSERWNPTQNV
70 80 90 100 110 120
120 130 140 150 160
pF1KE1 EKILLSVVSMLAEPNDESGANVDASKM---WRD----DREQFYKIAKQIVQKSLGL
. :::::.:.: ::: : :::::: : ::: :.: : ::.
NP_060 RTILLSVISLLNEPNTFSPANVDASVMFRKWRDSKGKDKEYAEIIRKQVSATKAEAEKDG
130 140 150 160 170 180
NP_060 VKVPTTLAEYCIKTKVPSNDNSSDLLYDDLYDDDIDDEDEEEEDADCYDDDDSGNEES
190 200 210 220 230
>>NP_004350 (OMIM: 116948) ubiquitin-conjugating enzyme (236 aa)
initn: 499 init1: 465 opt: 504 Z-score: 612.1 bits: 120.1 E(85289): 2.3e-27
Smith-Waterman score: 504; 48.2% identity (69.9% similar) in 166 aa overlap (1-159:5-170)
10 20 30 40 50
pF1KE1 MAGTALKRLMAEYKQLTLNPPEGIVAGPMNEENFFEWEALIMGPEDTCFEFGVFPA
.. .. : :. : : : .: ::. . ..: ....::. :.:: .: .: : : :
NP_004 MARPLVPSSQKALLLELKGLQEEPVEGFRVTLVDEGDLYNWEVAIFGPPNTYYEGGYFKA
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 ILSFPLDYPLSPPKMRFTCEMFHPNIYPDGRVCISILHAPGDDPMGYESSAERWSPVQSV
:.::.::: ::: .:: .:.::::: : ::::::: : :::.. : .:::.:.:.:
NP_004 RLKFPIDYPYSPPAFRFLTKMWHPNIYETGDVCISILHPPVDDPQSGELPSERWNPTQNV
70 80 90 100 110 120
120 130 140 150 160
pF1KE1 EKILLSVVSMLAEPNDESGANVDASKM---WRD----DREQFYKIAKQIVQKSLGL
. :::::.:.: ::: : :::::: : :.. ::: : ::..
NP_004 RTILLSVISLLNEPNTFSPANVDASVMYRKWKESKGKDREYTDIIRKQVLGTKVDAERDG
130 140 150 160 170 180
NP_004 VKVPTTLAEYCVKTKAPAPDEGSDLFYDDYYEDGEVEEEADSCFGDDEDDSGTEES
190 200 210 220 230
>>XP_006723015 (OMIM: 116948) PREDICTED: ubiquitin-conju (179 aa)
initn: 493 init1: 465 opt: 501 Z-score: 610.2 bits: 119.3 E(85289): 3e-27
Smith-Waterman score: 501; 47.6% identity (71.7% similar) in 166 aa overlap (1-164:5-170)
10 20 30 40 50
pF1KE1 MAGTALKRLMAEYKQLTLNPPEGIVAGPMNEENFFEWEALIMGPEDTCFEFGVFPA
.. .. : :. : : : .: ::. . ..: ....::. :.:: .: .: : : :
XP_006 MARPLVPSSQKALLLELKGLQEEPVEGFRVTLVDEGDLYNWEVAIFGPPNTYYEGGYFKA
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 ILSFPLDYPLSPPKMRFTCEMFHPNIYPDGRVCISILHAPGDDPMGYESSAERWSPVQSV
:.::.::: ::: .:: .:.::::: : ::::::: : :::.. : .:::.:.:.:
XP_006 RLKFPIDYPYSPPAFRFLTKMWHPNIYETGDVCISILHPPVDDPQSGELPSERWNPTQNV
70 80 90 100 110 120
120 130 140 150 160
pF1KE1 EKILLSVVSMLAEPNDESGANVDASKMWRDDREQFYKIAK--QIVQKSLGL
. :::::.:.: ::: : :::::: :.: .:. : . .:...: :
XP_006 RTILLSVISLLNEPNTFSPANVDASVMYRKWKESKGKDREYTDIIRRSWGPRWTRSVTA
130 140 150 160 170
>>XP_005259747 (OMIM: 116948) PREDICTED: ubiquitin-conju (269 aa)
initn: 480 init1: 465 opt: 497 Z-score: 602.9 bits: 118.6 E(85289): 7.6e-27
Smith-Waterman score: 497; 50.3% identity (73.2% similar) in 149 aa overlap (1-149:5-153)
10 20 30 40 50
pF1KE1 MAGTALKRLMAEYKQLTLNPPEGIVAGPMNEENFFEWEALIMGPEDTCFEFGVFPA
.. .. : :. : : : .: ::. . ..: ....::. :.:: .: .: : : :
XP_005 MARPLVPSSQKALLLELKGLQEEPVEGFRVTLVDEGDLYNWEVAIFGPPNTYYEGGYFKA
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 ILSFPLDYPLSPPKMRFTCEMFHPNIYPDGRVCISILHAPGDDPMGYESSAERWSPVQSV
:.::.::: ::: .:: .:.::::: : ::::::: : :::.. : .:::.:.:.:
XP_005 RLKFPIDYPYSPPAFRFLTKMWHPNIYETGDVCISILHPPVDDPQSGELPSERWNPTQNV
70 80 90 100 110 120
120 130 140 150 160
pF1KE1 EKILLSVVSMLAEPNDESGANVDASKMWRDDREQFYKIAKQIVQKSLGL
. :::::.:.: ::: : :::::: :.: .:
XP_005 RTILLSVISLLNEPNTFSPANVDASVMYRKWKESKGKDREYTDIIRTQEHPGHLPSCTRW
130 140 150 160 170 180
XP_005 YLVSWGHLGAASWCWAVSALSSHGGRAPCGLLGSGLQAPAGLWRSQGSCPGRPSGADVLG
190 200 210 220 230 240
>>XP_011516251 (OMIM: 612506) PREDICTED: ubiquitin-conju (193 aa)
initn: 406 init1: 392 opt: 397 Z-score: 485.2 bits: 96.3 E(85289): 2.7e-20
Smith-Waterman score: 397; 48.7% identity (73.9% similar) in 115 aa overlap (4-118:8-122)
10 20 30 40 50
pF1KE1 MAGTALKRLMAEYKQLTLNPPEGIVAGPMNEENFFEWEALIMGPEDTCFEFGVFPA
.. : :: : :.: .: ::. ..: ....::. :.:: .: .: : : :
XP_011 MAQQQMTSSQKALMLELKSLQEEPVEGFRITLVDESDLYNWEVAIFGPPNTLYEGGYFKA
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 ILSFPLDYPLSPPKMRFTCEMFHPNIYPDGRVCISILHAPGDDPMGYESSAERWSPVQSV
..::.::: ::: .:: .:.::::: .: ::::::: : :::.. : .:::.:.:.:
XP_011 HIKFPIDYPYSPPTFRFLTKMWHPNIYENGDVCISILHPPVDDPQSGELPSERWNPTQNV
70 80 90 100 110 120
120 130 140 150 160
pF1KE1 EKILLSVVSMLAEPNDESGANVDASKMWRDDREQFYKIAKQIVQKSLGL
.:
XP_011 RKQVSATKAEAEKDGVKVPTTLAEYCIKTKVPSNDNSSDLLYDDLYDDDIDDEDEEEEDA
130 140 150 160 170 180
165 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 12:57:33 2016 done: Sun Nov 6 12:57:34 2016
Total Scan time: 5.330 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]