FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE9503, 384 aa 1>>>pF1KE9503 384 - 384 aa - 384 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.7038+/-0.000372; mu= 20.8451+/- 0.023 mean_var=127.4814+/-34.131, 0's: 0 Z-trim(114.4): 347 B-trim: 1317 in 1/49 Lambda= 0.113593 statistics sampled from 23764 (24275) to 23764 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.642), E-opt: 0.2 (0.285), width: 16 Scan time: 7.630 The best scores are: opt bits E(85289) NP_003766 (OMIM: 603751) sphingosine 1-phosphate r ( 384) 2540 428.1 1.7e-119 NP_005217 (OMIM: 601965) sphingosine 1-phosphate r ( 378) 852 151.4 3.2e-36 NP_001391 (OMIM: 601974) sphingosine 1-phosphate r ( 382) 828 147.5 5e-35 NP_001307659 (OMIM: 601974) sphingosine 1-phosphat ( 382) 828 147.5 5e-35 NP_004221 (OMIM: 605111,610419,610419) sphingosine ( 353) 691 125.0 2.7e-28 NP_004711 (OMIM: 605110) lysophosphatidic acid rec ( 351) 622 113.7 6.9e-25 XP_016882957 (OMIM: 605110) PREDICTED: lysophospha ( 351) 622 113.7 6.9e-25 XP_011526723 (OMIM: 605110) PREDICTED: lysophospha ( 351) 622 113.7 6.9e-25 XP_016882958 (OMIM: 605110) PREDICTED: lysophospha ( 351) 622 113.7 6.9e-25 NP_110387 (OMIM: 605146) sphingosine 1-phosphate r ( 398) 610 111.8 2.9e-24 NP_001159687 (OMIM: 605146) sphingosine 1-phosphat ( 398) 610 111.8 2.9e-24 XP_016869879 (OMIM: 602282) PREDICTED: lysophospha ( 364) 566 104.5 4.1e-22 XP_005251839 (OMIM: 602282) PREDICTED: lysophospha ( 364) 566 104.5 4.1e-22 NP_001392 (OMIM: 602282) lysophosphatidic acid rec ( 364) 566 104.5 4.1e-22 XP_016869882 (OMIM: 602282) PREDICTED: lysophospha ( 364) 566 104.5 4.1e-22 XP_016869883 (OMIM: 602282) PREDICTED: lysophospha ( 364) 566 104.5 4.1e-22 XP_016869878 (OMIM: 602282) PREDICTED: lysophospha ( 364) 566 104.5 4.1e-22 XP_016869886 (OMIM: 602282) PREDICTED: lysophospha ( 364) 566 104.5 4.1e-22 XP_016869877 (OMIM: 602282) PREDICTED: lysophospha ( 364) 566 104.5 4.1e-22 XP_016869887 (OMIM: 602282) PREDICTED: lysophospha ( 364) 566 104.5 4.1e-22 XP_016869888 (OMIM: 602282) PREDICTED: lysophospha ( 364) 566 104.5 4.1e-22 XP_016869876 (OMIM: 602282) PREDICTED: lysophospha ( 364) 566 104.5 4.1e-22 XP_016869894 (OMIM: 602282) PREDICTED: lysophospha ( 364) 566 104.5 4.1e-22 XP_016869880 (OMIM: 602282) PREDICTED: lysophospha ( 364) 566 104.5 4.1e-22 XP_016869892 (OMIM: 602282) PREDICTED: lysophospha ( 364) 566 104.5 4.1e-22 XP_016869893 (OMIM: 602282) PREDICTED: lysophospha ( 364) 566 104.5 4.1e-22 XP_016869891 (OMIM: 602282) PREDICTED: lysophospha ( 364) 566 104.5 4.1e-22 XP_016869885 (OMIM: 602282) PREDICTED: lysophospha ( 364) 566 104.5 4.1e-22 XP_016869890 (OMIM: 602282) PREDICTED: lysophospha ( 364) 566 104.5 4.1e-22 XP_016869872 (OMIM: 602282) PREDICTED: lysophospha ( 364) 566 104.5 4.1e-22 XP_005251838 (OMIM: 602282) PREDICTED: lysophospha ( 364) 566 104.5 4.1e-22 XP_016869874 (OMIM: 602282) PREDICTED: lysophospha ( 364) 566 104.5 4.1e-22 XP_016869884 (OMIM: 602282) PREDICTED: lysophospha ( 364) 566 104.5 4.1e-22 XP_016869875 (OMIM: 602282) PREDICTED: lysophospha ( 364) 566 104.5 4.1e-22 XP_016869881 (OMIM: 602282) PREDICTED: lysophospha ( 364) 566 104.5 4.1e-22 XP_016869896 (OMIM: 602282) PREDICTED: lysophospha ( 364) 566 104.5 4.1e-22 NP_476500 (OMIM: 602282) lysophosphatidic acid rec ( 364) 566 104.5 4.1e-22 XP_016869895 (OMIM: 602282) PREDICTED: lysophospha ( 364) 566 104.5 4.1e-22 XP_016869873 (OMIM: 602282) PREDICTED: lysophospha ( 364) 566 104.5 4.1e-22 XP_016869889 (OMIM: 602282) PREDICTED: lysophospha ( 364) 566 104.5 4.1e-22 NP_036284 (OMIM: 605106) lysophosphatidic acid rec ( 353) 552 102.2 2e-21 NP_005272 (OMIM: 600241) G-protein coupled recepto ( 330) 384 74.6 3.7e-13 NP_001832 (OMIM: 605051) cannabinoid receptor 2 [H ( 360) 374 73.1 1.2e-12 XP_011538931 (OMIM: 605051) PREDICTED: cannabinoid ( 360) 374 73.1 1.2e-12 XP_016855750 (OMIM: 605051) PREDICTED: cannabinoid ( 360) 374 73.1 1.2e-12 NP_005279 (OMIM: 600752) G-protein coupled recepto ( 334) 346 68.4 2.8e-11 NP_005275 (OMIM: 600553) G-protein coupled recepto ( 362) 327 65.4 2.5e-10 NP_001273028 (OMIM: 600553) G-protein coupled rece ( 377) 327 65.4 2.6e-10 NP_000530 (OMIM: 136880,180380,610445,613731) rhod ( 348) 274 56.6 1e-07 NP_061822 (OMIM: 600896) urotensin-2 receptor [Hom ( 389) 272 56.4 1.3e-07 >>NP_003766 (OMIM: 603751) sphingosine 1-phosphate recep (384 aa) initn: 2540 init1: 2540 opt: 2540 Z-score: 2266.2 bits: 428.1 E(85289): 1.7e-119 Smith-Waterman score: 2540; 100.0% identity (100.0% similar) in 384 aa overlap (1-384:1-384) 10 20 30 40 50 60 pF1KE9 MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 VLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 VLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 REGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 REGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 LLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAPRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAPRP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 AARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 AARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 AVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTDSSLRPRDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 AVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTDSSLRPRDS 310 320 330 340 350 360 370 380 pF1KE9 FRGSRSLSFRMREPLSSISSVRSI :::::::::::::::::::::::: NP_003 FRGSRSLSFRMREPLSSISSVRSI 370 380 >>NP_005217 (OMIM: 601965) sphingosine 1-phosphate recep (378 aa) initn: 822 init1: 418 opt: 852 Z-score: 771.2 bits: 151.4 E(85289): 3.2e-36 Smith-Waterman score: 858; 42.8% identity (69.0% similar) in 348 aa overlap (28-375:21-355) 10 20 30 40 50 60 pF1KE9 MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLV ::.. :.:::: . : : .. .. NP_005 MATALPPRLQPVRGNETLREHYQYVGKLAGRLKEASEGSTLTTVLFLVICSFI 10 20 30 40 50 70 80 90 100 110 120 pF1KE9 VLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFL :::::.:: :: .. . . .:. . :..: :::.: :: .:.:.:: .:: :.:. ::: NP_005 VLENLMVLIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKVNILMSGKKTFSLSPTVWFL 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE9 REGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLP ::: .:.::.::: ::: : :: ::.. . :.: ::. .::.:::.: :: :: NP_005 REGSMFVALGASTCSLLAIAIERHLTMIK-MRPYDANKRHRVFLLIGMCWLIAFTLGALP 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE9 LLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAPRP .:::::: . ::..::::::.:: ::. ::...:.::. ::. :. ::..:..:. NP_005 ILGWNCLHNLPDCSTILPLYSKKYIAFCISIFTAILVTIVILYARIYFLVKSSSRKVANH 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE9 AARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNS ... ::.::.... .:..::.::: :.: :: . . : : .:...:::::: NP_005 NNSERSMALLRTVVIVVSVFIACWSPLFILFLIDV-ACRVQACPILFKAQWFIVLAVLNS 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE9 AVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTDSSLRPRDS :.::.::.. :.:. :: . : :.:: .:: : ::: . . : : : ..: NP_005 AMNPVIYTLASKEMRRAFFR-LVCNCL---VRGRG---ARASPIQPA---LDPS-RSKSS 300 310 320 330 340 370 380 pF1KE9 FRGSRSLSFRMREPLSSISSVRSI .. : : ...: : NP_005 SSNNSSHSPKVKEDLPHTAPSSCIMDKNAALQNGIFCN 350 360 370 >>NP_001391 (OMIM: 601974) sphingosine 1-phosphate recep (382 aa) initn: 722 init1: 333 opt: 828 Z-score: 749.9 bits: 147.5 E(85289): 5e-35 Smith-Waterman score: 828; 41.0% identity (72.8% similar) in 334 aa overlap (1-326:1-331) 10 20 30 40 50 60 pF1KE9 MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLV :. :..:.. .... . .:: :::..:.: . :.. . . . :.. NP_001 MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENS-IKLTSVVFILICCFI 10 20 30 40 50 70 80 90 100 110 120 pF1KE9 VLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFL .:::..:: .: . . .: .:: . :..:::::.:.:: ::.::::: :..:.:::::: NP_001 ILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFL 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE9 REGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLP ::: .:.::.::.:::: : ::. ::.. ..: ... :.. .:. ::... .:: :: NP_001 REGSMFVALSASVFSLLAIAIERYITMLKMKLHNG-SNNFRLFLLISACWVISLILGGLP 120 130 140 150 160 170 190 200 210 220 230 pF1KE9 LLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQ----- ..::::. :.. ::..:::: :.::::: ..:. .: .:. :: :. ::.. .. NP_001 IMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFR 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE9 KAPRPAAR--RKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWIL : :.: .:. :::::...: .:..::.::: ::: :: : .. . . : ...: NP_001 KNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDV-GCKVKTCDILFRAEYFL 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE9 ALAVLNSAVNPIIYSFRSREVCRAVLSFL-CCGCLRLGMRGPGDCLARAVEAHSGASTTD .::::::..:::::.. ..:. :: . .. :: : NP_001 VLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDN 300 310 320 330 340 350 360 370 380 pF1KE9 SSLRPRDSFRGSRSLSFRMREPLSSISSVRSI NP_001 SSHPQKDEGDNPETIMSSGNVNSSS 360 370 380 >>NP_001307659 (OMIM: 601974) sphingosine 1-phosphate re (382 aa) initn: 722 init1: 333 opt: 828 Z-score: 749.9 bits: 147.5 E(85289): 5e-35 Smith-Waterman score: 828; 41.0% identity (72.8% similar) in 334 aa overlap (1-326:1-331) 10 20 30 40 50 60 pF1KE9 MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLV :. :..:.. .... . .:: :::..:.: . :.. . . . :.. NP_001 MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENS-IKLTSVVFILICCFI 10 20 30 40 50 70 80 90 100 110 120 pF1KE9 VLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFL .:::..:: .: . . .: .:: . :..:::::.:.:: ::.::::: :..:.:::::: NP_001 ILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFL 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE9 REGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLP ::: .:.::.::.:::: : ::. ::.. ..: ... :.. .:. ::... .:: :: NP_001 REGSMFVALSASVFSLLAIAIERYITMLKMKLHNG-SNNFRLFLLISACWVISLILGGLP 120 130 140 150 160 170 190 200 210 220 230 pF1KE9 LLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQ----- ..::::. :.. ::..:::: :.::::: ..:. .: .:. :: :. ::.. .. NP_001 IMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFR 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE9 KAPRPAAR--RKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWIL : :.: .:. :::::...: .:..::.::: ::: :: : .. . . : ...: NP_001 KNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDV-GCKVKTCDILFRAEYFL 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE9 ALAVLNSAVNPIIYSFRSREVCRAVLSFL-CCGCLRLGMRGPGDCLARAVEAHSGASTTD .::::::..:::::.. ..:. :: . .. :: : NP_001 VLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDN 300 310 320 330 340 350 360 370 380 pF1KE9 SSLRPRDSFRGSRSLSFRMREPLSSISSVRSI NP_001 SSHPQKDEGDNPETIMSSGNVNSSS 360 370 380 >>NP_004221 (OMIM: 605111,610419,610419) sphingosine 1-p (353 aa) initn: 653 init1: 277 opt: 691 Z-score: 628.9 bits: 125.0 E(85289): 2.7e-28 Smith-Waterman score: 691; 41.8% identity (70.4% similar) in 280 aa overlap (54-333:41-314) 30 40 50 60 70 80 pF1KE9 LIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLVVLENLLVLAAITSHMRSRRWVYY : : .:.:::::: :.. . . . .: NP_004 PNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVARNSKFHSAMYL 20 30 40 50 60 70 90 100 110 120 130 140 pF1KE9 CLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFLREGLLFTALAASTFSLLFTAGER : :.. ::::.:.:..::.::::. :.::.:.::: ::: : .:.::.:::: : :: NP_004 FLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASVFSLLAIAIER 80 90 100 110 120 130 150 160 170 180 190 200 pF1KE9 FATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLPLLGWNCLCAFDRCSSLLPLYSKR ..... : :. :. :. .:: ::.. .:: ::.:::::: .. ::..::::.:. NP_004 HVAIAK-VKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKH 140 150 160 170 180 210 220 230 240 250 260 pF1KE9 YILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAPRPAARRKARRLLKTVLMILLAFLVC :.: ..::. .: .:..:: :. .:..: : .. ::::: ..: .:.:: NP_004 YVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAP----QTLALLKTVTIVLGVFIVC 190 200 210 220 230 240 270 280 290 300 310 320 pF1KE9 WGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNSAVNPIIYSFRSREVCRAVLSFLC : : :..:: : .. . . : ...:...::: .::.::..:::.. : :: : NP_004 WLPAFSILLLD-YACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVLRPLQ 250 260 270 280 290 300 330 340 350 360 370 380 pF1KE9 CGCLRLGMRGPGDCLARAVEAHSGASTTDSSLRPRDSFRGSRSLSFRMREPLSSISSVRS : .:..: NP_004 CWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV 310 320 330 340 350 >>NP_004711 (OMIM: 605110) lysophosphatidic acid recepto (351 aa) initn: 588 init1: 233 opt: 622 Z-score: 567.8 bits: 113.7 E(85289): 6.9e-25 Smith-Waterman score: 622; 39.0% identity (64.0% similar) in 336 aa overlap (21-350:9-335) 10 20 30 40 50 pF1KE9 MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGR-LAGRGGPEDGGLGALRGLSVAASCL ... : . ::.::. :... :.: . :: ::.: : : NP_004 MVIMGQCYYNETIGFFYNNSGKELSSHWRPKDVVVVAL-GLTV--SVL 10 20 30 40 60 70 80 90 100 110 pF1KE9 VVLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWF :.: ::::.:::.:. : .. .:: : :.. .::..:.::: .. .: :: ::. :: NP_004 VLLTNLLVIAAIASNRRFHQPIYYLLGNLAAADLFAGVAYLFLMFHTGPRTARLSLEGWF 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE9 LREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGML ::.::: :.:.::. .:: : :: . : : . .:: .: :. : ::.: NP_004 LRQGLLDTSLTASVATLLAIAVERHRS-VMAVQLHSRLPRGRVVMLIVGVWVAALGLGLL 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE9 PLLGWNCLCAFDRCSSLLPLYSKRYI----LFCLVIFAGVLATIMGLYGAIFRLVQASGQ : .:.::::.:::: . :: :. :. : :..: ..:. .. . : :: .. NP_004 PAHSWHCLCALDRCSRMAPLLSRSYLAVWALSSLLVFLLMVAVYTRIFFYVRRRVQRMAE 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE9 KAP-RPAARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILA .. .: :. . :.:::..:: ::.::: : .:: : .: . . . : ..: NP_004 HVSCHPRYRETTLSLVKTVVIILGAFVVCWTPGQVVLLLDGLGCE--SCNVLAVEKYFLL 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE9 LAVLNSAVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTDSS :: :: :: .:: :. :. :. .:::.::: . : . . . :..:::: NP_004 LAEANSLVNAAVYSCRDAEMRRTFRRLLCCACLRQSTR---ESVHYTSSAQGGASTRIML 290 300 310 320 330 360 370 380 pF1KE9 LRPRDSFRGSRSLSFRMREPLSSISSVRSI NP_004 PENGHPLMDSTL 340 350 >>XP_016882957 (OMIM: 605110) PREDICTED: lysophosphatidi (351 aa) initn: 588 init1: 233 opt: 622 Z-score: 567.8 bits: 113.7 E(85289): 6.9e-25 Smith-Waterman score: 622; 39.0% identity (64.0% similar) in 336 aa overlap (21-350:9-335) 10 20 30 40 50 pF1KE9 MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGR-LAGRGGPEDGGLGALRGLSVAASCL ... : . ::.::. :... :.: . :: ::.: : : XP_016 MVIMGQCYYNETIGFFYNNSGKELSSHWRPKDVVVVAL-GLTV--SVL 10 20 30 40 60 70 80 90 100 110 pF1KE9 VVLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWF :.: ::::.:::.:. : .. .:: : :.. .::..:.::: .. .: :: ::. :: XP_016 VLLTNLLVIAAIASNRRFHQPIYYLLGNLAAADLFAGVAYLFLMFHTGPRTARLSLEGWF 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE9 LREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGML ::.::: :.:.::. .:: : :: . : : . .:: .: :. : ::.: XP_016 LRQGLLDTSLTASVATLLAIAVERHRS-VMAVQLHSRLPRGRVVMLIVGVWVAALGLGLL 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE9 PLLGWNCLCAFDRCSSLLPLYSKRYI----LFCLVIFAGVLATIMGLYGAIFRLVQASGQ : .:.::::.:::: . :: :. :. : :..: ..:. .. . : :: .. XP_016 PAHSWHCLCALDRCSRMAPLLSRSYLAVWALSSLLVFLLMVAVYTRIFFYVRRRVQRMAE 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE9 KAP-RPAARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILA .. .: :. . :.:::..:: ::.::: : .:: : .: . . . : ..: XP_016 HVSCHPRYRETTLSLVKTVVIILGAFVVCWTPGQVVLLLDGLGCE--SCNVLAVEKYFLL 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE9 LAVLNSAVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTDSS :: :: :: .:: :. :. :. .:::.::: . : . . . :..:::: XP_016 LAEANSLVNAAVYSCRDAEMRRTFRRLLCCACLRQSTR---ESVHYTSSAQGGASTRIML 290 300 310 320 330 360 370 380 pF1KE9 LRPRDSFRGSRSLSFRMREPLSSISSVRSI XP_016 PENGHPLMDSTL 340 350 >>XP_011526723 (OMIM: 605110) PREDICTED: lysophosphatidi (351 aa) initn: 588 init1: 233 opt: 622 Z-score: 567.8 bits: 113.7 E(85289): 6.9e-25 Smith-Waterman score: 622; 39.0% identity (64.0% similar) in 336 aa overlap (21-350:9-335) 10 20 30 40 50 pF1KE9 MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGR-LAGRGGPEDGGLGALRGLSVAASCL ... : . ::.::. :... :.: . :: ::.: : : XP_011 MVIMGQCYYNETIGFFYNNSGKELSSHWRPKDVVVVAL-GLTV--SVL 10 20 30 40 60 70 80 90 100 110 pF1KE9 VVLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWF :.: ::::.:::.:. : .. .:: : :.. .::..:.::: .. .: :: ::. :: XP_011 VLLTNLLVIAAIASNRRFHQPIYYLLGNLAAADLFAGVAYLFLMFHTGPRTARLSLEGWF 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE9 LREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGML ::.::: :.:.::. .:: : :: . : : . .:: .: :. : ::.: XP_011 LRQGLLDTSLTASVATLLAIAVERHRS-VMAVQLHSRLPRGRVVMLIVGVWVAALGLGLL 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE9 PLLGWNCLCAFDRCSSLLPLYSKRYI----LFCLVIFAGVLATIMGLYGAIFRLVQASGQ : .:.::::.:::: . :: :. :. : :..: ..:. .. . : :: .. XP_011 PAHSWHCLCALDRCSRMAPLLSRSYLAVWALSSLLVFLLMVAVYTRIFFYVRRRVQRMAE 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE9 KAP-RPAARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILA .. .: :. . :.:::..:: ::.::: : .:: : .: . . . : ..: XP_011 HVSCHPRYRETTLSLVKTVVIILGAFVVCWTPGQVVLLLDGLGCE--SCNVLAVEKYFLL 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE9 LAVLNSAVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTDSS :: :: :: .:: :. :. :. .:::.::: . : . . . :..:::: XP_011 LAEANSLVNAAVYSCRDAEMRRTFRRLLCCACLRQSTR---ESVHYTSSAQGGASTRIML 290 300 310 320 330 360 370 380 pF1KE9 LRPRDSFRGSRSLSFRMREPLSSISSVRSI XP_011 PENGHPLMDSTL 340 350 >>XP_016882958 (OMIM: 605110) PREDICTED: lysophosphatidi (351 aa) initn: 588 init1: 233 opt: 622 Z-score: 567.8 bits: 113.7 E(85289): 6.9e-25 Smith-Waterman score: 622; 39.0% identity (64.0% similar) in 336 aa overlap (21-350:9-335) 10 20 30 40 50 pF1KE9 MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGR-LAGRGGPEDGGLGALRGLSVAASCL ... : . ::.::. :... :.: . :: ::.: : : XP_016 MVIMGQCYYNETIGFFYNNSGKELSSHWRPKDVVVVAL-GLTV--SVL 10 20 30 40 60 70 80 90 100 110 pF1KE9 VVLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWF :.: ::::.:::.:. : .. .:: : :.. .::..:.::: .. .: :: ::. :: XP_016 VLLTNLLVIAAIASNRRFHQPIYYLLGNLAAADLFAGVAYLFLMFHTGPRTARLSLEGWF 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE9 LREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGML ::.::: :.:.::. .:: : :: . : : . .:: .: :. : ::.: XP_016 LRQGLLDTSLTASVATLLAIAVERHRS-VMAVQLHSRLPRGRVVMLIVGVWVAALGLGLL 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE9 PLLGWNCLCAFDRCSSLLPLYSKRYI----LFCLVIFAGVLATIMGLYGAIFRLVQASGQ : .:.::::.:::: . :: :. :. : :..: ..:. .. . : :: .. XP_016 PAHSWHCLCALDRCSRMAPLLSRSYLAVWALSSLLVFLLMVAVYTRIFFYVRRRVQRMAE 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE9 KAP-RPAARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILA .. .: :. . :.:::..:: ::.::: : .:: : .: . . . : ..: XP_016 HVSCHPRYRETTLSLVKTVVIILGAFVVCWTPGQVVLLLDGLGCE--SCNVLAVEKYFLL 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE9 LAVLNSAVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTDSS :: :: :: .:: :. :. :. .:::.::: . : . . . :..:::: XP_016 LAEANSLVNAAVYSCRDAEMRRTFRRLLCCACLRQSTR---ESVHYTSSAQGGASTRIML 290 300 310 320 330 360 370 380 pF1KE9 LRPRDSFRGSRSLSFRMREPLSSISSVRSI XP_016 PENGHPLMDSTL 340 350 >>NP_110387 (OMIM: 605146) sphingosine 1-phosphate recep (398 aa) initn: 816 init1: 346 opt: 610 Z-score: 556.7 bits: 111.8 E(85289): 2.9e-24 Smith-Waterman score: 824; 42.7% identity (67.1% similar) in 377 aa overlap (22-383:12-381) 10 20 30 40 50 60 pF1KE9 MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLV :..::::::..:.: : .:: : . .:. .. NP_110 MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFI 10 20 30 40 50 70 80 90 100 110 120 pF1KE9 VLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFL ::::: :: .. : : . .. : ..::::::.:::: ::.:::: :..:.:: :: NP_110 VLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFA 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE9 REGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLP ::: .:.::.::..::: : :: ::.: . . ... .:. .. . : .. :::.:: NP_110 REGGVFVALTASVLSLLAIALERSLTMARR-GPAPVSSRGRTLAMAAAAWGVSLLLGLLP 120 130 140 150 160 190 200 210 220 230 pF1KE9 LLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAP-R :::::: .: ::..::::.: :.:::.. :.:.::.: .::. :. :.:.... : : NP_110 ALGWNCLGRLDACSTVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPAR 170 180 190 200 210 220 240 250 260 270 280 pF1KE9 PA--------ARRKARRL--LKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGM :. :::: : : :.:. ..::::..:::::: ::: :: . . : NP_110 PGTAGTTSTRARRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDV-ACPARTCPVLLQA 230 240 250 260 270 280 290 300 310 320 330 340 pF1KE9 DWILALAVLNSAVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGPGDCL--ARAVEAHSG : .:.::. :: .:::::.. .:.. .:.: ..::: : : :. : :.:: .: NP_110 DPFLGLAMANSLLNPIIYTLTNRDLRHALLRLVCCGRHSCG-RDPSGSQQSASAAEASGG 290 300 310 320 330 340 350 360 370 380 pF1KE9 ASTTDSSLRP--RDSFRGSRSLSFRMREPLSSISSVRSI : : :: ::. : .:. :.. .:. : NP_110 LRRC---LPPGLDGSFSGSERSS-PQRDGLDTSGSTGSPGAPTAARTLVSEPAAD 350 360 370 380 390 384 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 13:34:40 2016 done: Sun Nov 6 13:34:41 2016 Total Scan time: 7.630 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]