Result of FASTA (omim) for
pFN21AB7819
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB7819, 535 aa
1>>>pF1KB7819 535 - 535 aa - 535 aa
Library: /omim/omim.rfq.tfa
64369986 residues in 92320 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.2359+/-0.000373; mu= 2.7439+/- 0.023
mean_var=280.9192+/-57.408, 0's: 0 Z-trim(122.9): 72 B-trim: 760 in 1/53
Lambda= 0.076522
statistics sampled from 43470 (43544) to 43470 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.778), E-opt: 0.2 (0.472), width: 16
Scan time: 5.510
The best scores are: opt bits E(92320)
NP_037483 (OMIM: 208550,604895) T-box transcriptio ( 535) 3821 435.2 2.7e-121
NP_001265111 (OMIM: 604615) eomesodermin homolog i ( 705) 1145 139.9 2.8e-32
NP_006584 (OMIM: 604616,606053) T-box brain protei ( 682) 1127 137.9 1.1e-31
XP_005265567 (OMIM: 604615) eomesodermin homolog i ( 515) 1096 134.3 9.4e-31
NP_005433 (OMIM: 604615) eomesodermin homolog isof ( 686) 1083 133.0 3.1e-30
NP_001265112 (OMIM: 604615) eomesodermin homolog i ( 410) 935 116.4 1.8e-25
XP_011523797 (OMIM: 147891,601719) T-box transcrip ( 417) 716 92.3 3.4e-18
XP_016884414 (OMIM: 187500,188400,192430,217095,60 ( 545) 717 92.5 3.8e-18
NP_542378 (OMIM: 187500,188400,192430,217095,60205 ( 495) 716 92.3 3.9e-18
XP_016884415 (OMIM: 187500,188400,192430,217095,60 ( 495) 716 92.3 3.9e-18
XP_006724375 (OMIM: 187500,188400,192430,217095,60 ( 495) 716 92.3 3.9e-18
XP_011523793 (OMIM: 147891,601719) T-box transcrip ( 608) 716 92.4 4.5e-18
XP_011523792 (OMIM: 147891,601719) T-box transcrip ( 609) 716 92.4 4.5e-18
NP_060958 (OMIM: 147891,601719) T-box transcriptio ( 545) 713 92.1 5.2e-18
NP_001308049 (OMIM: 147891,601719) T-box transcrip ( 546) 713 92.1 5.2e-18
NP_005983 (OMIM: 187500,188400,192430,217095,60205 ( 372) 697 90.1 1.4e-17
NP_542377 (OMIM: 187500,188400,192430,217095,60205 ( 398) 697 90.2 1.4e-17
XP_016884417 (OMIM: 187500,188400,192430,217095,60 ( 448) 698 90.3 1.4e-17
XP_016875401 (OMIM: 142900,601620) T-box transcrip ( 534) 692 89.7 2.6e-17
NP_000183 (OMIM: 142900,601620) T-box transcriptio ( 518) 685 88.9 4.3e-17
NP_852259 (OMIM: 142900,601620) T-box transcriptio ( 518) 685 88.9 4.3e-17
NP_542448 (OMIM: 142900,601620) T-box transcriptio ( 468) 682 88.6 5e-17
NP_005985 (OMIM: 600747,618223) T-box transcriptio ( 712) 679 88.4 8.5e-17
NP_004599 (OMIM: 122600,602427) T-box transcriptio ( 436) 663 86.4 2e-16
XP_005255580 (OMIM: 122600,602427) T-box transcrip ( 436) 663 86.4 2e-16
XP_016879103 (OMIM: 122600,602427) T-box transcrip ( 436) 663 86.4 2e-16
XP_011544228 (OMIM: 122600,602427) T-box transcrip ( 436) 663 86.4 2e-16
XP_011543294 (OMIM: 604648) T-box transcription fa ( 430) 640 83.9 1.2e-15
XP_006715665 (OMIM: 143400,604613) T-box transcrip ( 364) 636 83.4 1.4e-15
XP_011534551 (OMIM: 143400,604613) T-box transcrip ( 372) 636 83.4 1.4e-15
XP_016866962 (OMIM: 143400,604613) T-box transcrip ( 376) 636 83.4 1.5e-15
XP_011534550 (OMIM: 143400,604613) T-box transcrip ( 377) 636 83.4 1.5e-15
NP_005987 (OMIM: 181450,601621) T-box transcriptio ( 723) 642 84.3 1.5e-15
XP_011534549 (OMIM: 143400,604613) T-box transcrip ( 379) 636 83.4 1.5e-15
NP_005986 (OMIM: 604648) T-box transcription facto ( 385) 634 83.2 1.7e-15
NP_001073977 (OMIM: 143400,604613) T-box transcrip ( 607) 636 83.6 2e-15
XP_016877519 (OMIM: 616061) MAX gene-associated pr (2207) 624 82.8 1.3e-14
NP_001074010 (OMIM: 616061) MAX gene-associated pr (2856) 624 82.9 1.5e-14
XP_005254310 (OMIM: 616061) MAX gene-associated pr (2906) 624 82.9 1.5e-14
XP_005254309 (OMIM: 616061) MAX gene-associated pr (2956) 624 82.9 1.6e-14
XP_011519700 (OMIM: 616061) MAX gene-associated pr (3004) 624 83.0 1.6e-14
XP_011519699 (OMIM: 616061) MAX gene-associated pr (3005) 624 83.0 1.6e-14
NP_001157745 (OMIM: 616061) MAX gene-associated pr (3065) 624 83.0 1.6e-14
XP_005254306 (OMIM: 616061) MAX gene-associated pr (3066) 624 83.0 1.6e-14
XP_005254305 (OMIM: 616061) MAX gene-associated pr (3114) 624 83.0 1.6e-14
XP_005254302 (OMIM: 616061) MAX gene-associated pr (3115) 624 83.0 1.6e-14
XP_005254301 (OMIM: 616061) MAX gene-associated pr (3115) 624 83.0 1.6e-14
XP_006720506 (OMIM: 616061) MAX gene-associated pr (3115) 624 83.0 1.6e-14
XP_005254303 (OMIM: 616061) MAX gene-associated pr (3115) 624 83.0 1.6e-14
XP_005254300 (OMIM: 616061) MAX gene-associated pr (3115) 624 83.0 1.6e-14
>>NP_037483 (OMIM: 208550,604895) T-box transcription fa (535 aa)
initn: 3821 init1: 3821 opt: 3821 Z-score: 2299.3 bits: 435.2 E(92320): 2.7e-121
Smith-Waterman score: 3821; 100.0% identity (100.0% similar) in 535 aa overlap (1-535:1-535)
10 20 30 40 50 60
pF1KB7 MGIVEPGCGDMLTGTEPMPGSDEGRAPGADPQHRYFYPEPGAQDADERRGGGSLGSPYPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 MGIVEPGCGDMLTGTEPMPGSDEGRAPGADPQHRYFYPEPGAQDADERRGGGSLGSPYPG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 GALVPAPPSRFLGAYAYPPRPQAAGFPGAGESFPPPADAEGYQPGEGYAAPDPRAGLYPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 GALVPAPPSRFLGAYAYPPRPQAAGFPGAGESFPPPADAEGYQPGEGYAAPDPRAGLYPG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 PREDYALPAGLEVSGKLRVALNNHLLWSKFNQHQTEMIITKQGRRMFPFLSFTVAGLEPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 PREDYALPAGLEVSGKLRVALNNHLLWSKFNQHQTEMIITKQGRRMFPFLSFTVAGLEPT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 SHYRMFVDVVLVDQHHWRYQSGKWVQCGKAEGSMPGNRLYVHPDSPNTGAHWMRQEVSFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 SHYRMFVDVVLVDQHHWRYQSGKWVQCGKAEGSMPGNRLYVHPDSPNTGAHWMRQEVSFG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 KLKLTNNKGASNNVTQMIVLQSLHKYQPRLHIVEVNDGEPEAACNASNTHIFTFQETQFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 KLKLTNNKGASNNVTQMIVLQSLHKYQPRLHIVEVNDGEPEAACNASNTHIFTFQETQFI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 AVTAYQNAEITQLKIDNNPFAKGFRENFESMYTSVDTSIPSPPGPNCQFLGGDHYSPLLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 AVTAYQNAEITQLKIDNNPFAKGFRENFESMYTSVDTSIPSPPGPNCQFLGGDHYSPLLP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB7 NQYPVPSRFYPDLPGQAKDVVPQAYWLGAPRDHSYEAEFRAVSMKPAFLPSAPGPTMSYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 NQYPVPSRFYPDLPGQAKDVVPQAYWLGAPRDHSYEAEFRAVSMKPAFLPSAPGPTMSYY
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB7 RGQEVLAPGAGWPVAPQYPPKMGPASWFRPMRTLPMEPGPGGSEGRGPEDQGPPLVWTEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 RGQEVLAPGAGWPVAPQYPPKMGPASWFRPMRTLPMEPGPGGSEGRGPEDQGPPLVWTEI
430 440 450 460 470 480
490 500 510 520 530
pF1KB7 APIRPESSDSGLGEGDSKRRRVSPYPSSGDSSSPAGAPSPFDKEAEGQFYNYFPN
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 APIRPESSDSGLGEGDSKRRRVSPYPSSGDSSSPAGAPSPFDKEAEGQFYNYFPN
490 500 510 520 530
>>NP_001265111 (OMIM: 604615) eomesodermin homolog isofo (705 aa)
initn: 1143 init1: 1006 opt: 1145 Z-score: 701.2 bits: 139.9 E(92320): 2.8e-32
Smith-Waterman score: 1225; 44.5% identity (63.1% similar) in 539 aa overlap (34-512:143-674)
10 20 30 40 50
pF1KB7 VEPGCGDMLTGTEPMPGSDEGRAPGADPQHRYFYPEPGAQDAD----------ERRGGGS
::. :: : .. . .:.
NP_001 ELPSAAAAAAAAAAAAAATARYSMDSLSSERYYLQSPGPQGSELAAPCSLFPYQAAAGAP
120 130 140 150 160 170
60 70 80 90 100
pF1KB7 LGS--PYPGGALVPA----PPSRFLGAYAYPPRPQAAGFPGAGE-SFPPPADAEGYQPGE
: : :.:: : ::. : .: : : : . :::: : ... : ::
NP_001 HGPVYPAPNGARYPYGSMLPPGGFPAAVCPPGRAQFG--PGAGAGSGAGGSSGGGGGPGT
180 190 200 210 220 230
110 120 130 140 150 160
pF1KB7 -GYAAPDPRAGLYPGPREDYALPA--GLEVSG---KLRVALNNHLLWSKFNQHQTEMIIT
:. : : ::: . . :: : : . .: : :. :: ::..::::::::
NP_001 YQYSQGAPLYGPYPGAAAAGSCGGLGGLGVPGSGFRAHVYLCNRPLWLKFHRHQTEMIIT
240 250 260 270 280 290
170 180 190 200 210 220
pF1KB7 KQGRRMFPFLSFTVAGLEPTSHYRMFVDVVLVDQHHWRYQSGKWVQCGKAEGSMPGNRLY
::::::::::::.. ::.::.:: .::.:::.: .:::.:.:::: ::::...: ::..:
NP_001 KQGRRMFPFLSFNINGLNPTAHYNVFVEVVLADPNHWRFQGGKWVTCGKADNNMQGNKMY
300 310 320 330 340 350
230 240 250 260 270 280
pF1KB7 VHPDSPNTGAHWMRQEVSFGKLKLTNNKGASNNVTQMIVLQSLHKYQPRLHIVEVNDGEP
:::.:::::.::::::.:::::::::::::.:: :::::::::::::::::::::..
NP_001 VHPESPNTGSHWMRQEISFGKLKLTNNKGANNNNTQMIVLQSLHKYQPRLHIVEVTEDGV
360 370 380 390 400 410
290 300 310 320 330
pF1KB7 EAACNASNTHIFTFQETQFIAVTAYQNAEITQLKIDNNPFAKGFRENFESMYTSV--DTS
: . :.:. :::.::::::::::::..:::::::.::::::::.:..::::. :
NP_001 EDLNEPSKTQTFTFSETQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDSMYTASENDRL
420 430 440 450 460 470
340 350 360 370 380
pF1KB7 IPSPP-GPNC-QFLGGDHYS--PLLPNQY--PVP-SRFY------PDL-----PGQAKDV
::: .: :.. : .:. ..:. . .: .:.: :. : :...:
NP_001 TPSPTDSPRSHQIVPGGRYGVQSFFPEPFVNTLPQARYYNGERTVPQTNGLLSPQQSEEV
480 490 500 510 520 530
390 400 410 420
pF1KB7 V-PQAYWLGAPRDH---------SYEAEFRAVSMKPAFLPSAPGPT---MSYYRGQEVLA
. : :: .: .. :::.:. . .. : . : : : ..:: . ..
NP_001 ANPPQRWLVTPVQQPGTNKLDISSYESEYTSSTLLPYGIKSLPLQTSHALGYY-PDPTFP
540 550 560 570 580
430 440 450 460 470 480
pF1KB7 PGAGWPVAPQYPPKMGPA-SWFRPMRTLPMEPGPGG-SEGRGPEDQGPPLVWTEIAP-IR
::: .: ::. . : :: : . :. . :. : : : : :.
NP_001 AMAGWGGRGSYQRKMAAGLPWTS--RTSPTVFSEDQLSKEKVKEEIGSS--WIETPPSIK
590 600 610 620 630 640
490 500 510 520 530
pF1KB7 P-ESSDSGLGEGDSKRRRVSPYPSSGDSSSPAGAPSPFDKEAEGQFYNYFPN
.:.:::. . ::::.:: ::...:
NP_001 SLDSNDSGVYTSACKRRRLSPSNSSNENSPSIKCEDINAEEYSKDTSKGMGGYYAFYTTP
650 660 670 680 690 700
>>NP_006584 (OMIM: 604616,606053) T-box brain protein 1 (682 aa)
initn: 1077 init1: 1025 opt: 1127 Z-score: 690.7 bits: 137.9 E(92320): 1.1e-31
Smith-Waterman score: 1142; 42.8% identity (64.6% similar) in 495 aa overlap (57-527:125-588)
30 40 50 60 70 80
pF1KB7 PGADPQHRYFYPEPGAQDADERRGGGSLGSPYPGGALVPAPPSRFLGAYAYPPRPQAAGF
:::: :: :. .:. : : :
NP_006 HSFDGSAADRYLLSQSSQPQSAATAPSAMFPYPGQHG-PAHPAFSIGS---PSR-YMAHH
100 110 120 130 140
90 100 110 120 130 140
pF1KB7 P----GAGESFPPPADAEGYQPGEGYAAPDPRAGLYPG-PREDYALPAGLEVSGKLRVAL
: :: .:. .. .:: : :: :. . : : : ... : :: .: :
NP_006 PVITNGAYNSLLSNSSPQGY-PTAGYPYPQQYGHSYQGAPFYQFSSTQPGLVPGKAQVYL
150 160 170 180 190 200
150 160 170 180 190 200
pF1KB7 NNHLLWSKFNQHQTEMIITKQGRRMFPFLSFTVAGLEPTSHYRMFVDVVLVDQHHWRYQS
:. :: ::..::::::::::::::::::::...::.::.:: .::::.:.: .:::.:.
NP_006 CNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNISGLDPTAHYNIFVDVILADPNHWRFQG
210 220 230 240 250 260
210 220 230 240 250 260
pF1KB7 GKWVQCGKAEGSMPGNRLYVHPDSPNTGAHWMRQEVSFGKLKLTNNKGASNNVTQMIVLQ
:::: ::::. .. :::.:.:::::::::::::::.:::::::::::::::: ::.:::
NP_006 GKWVPCGKADTNVQGNRVYMHPDSPNTGAHWMRQEISFGKLKLTNNKGASNNNGQMVVLQ
270 280 290 300 310 320
270 280 290 300 310 320
pF1KB7 SLHKYQPRLHIVEVNDGEPEAACNASNTHIFTFQETQFIAVTAYQNAEITQLKIDNNPFA
::::::::::.::::. : . . . .. ::: ::::::::::::..:::::::.::::
NP_006 SLHKYQPRLHVVEVNEDGTEDTSQPGRVQTFTFPETQFIAVTAYQNTDITQLKIDHNPFA
330 340 350 360 370 380
330 340 350 360 370
pF1KB7 KGFRENFESMYTSVDTS--IPSP-PGPNCQFLGGDHYS---PLLPNQYP---VPSRFYPD
::::.:....::. : . ::: .: :.. : .:. .: .:. . .::.:
NP_006 KGFRDNYDTIYTGCDMDRLTPSPNDSPRSQIVPGARYAMAGSFLQDQFVSNYAKARFHPG
390 400 410 420 430 440
380 390 400 410 420
pF1KB7 L---PGQAKD-VVPQAYWLGAPRDHSYEAEFRAVSMKPAFLPSAPGPTMSYYR--GQEVL
:: . : ::.. : .:. .:: :.::.: . ....
NP_006 AGAGPGPGTDRSVPHTNGLLSPQ----QAE----------DPGAPSPQRWFVTPANNRLD
450 460 470 480 490
430 440 450 460 470 480
pF1KB7 APGAGWPVAPQYPPKMGPASWFRP--MRTLPMEPGPGGSEGRGPEDQGPPLVWTEIAPIR
.... .: .. . . . ...::.. .: :: . : : .: .
NP_006 FAASAYDTATDFAGNAATLLSYAAAGVKALPLQA--AGCTGRPLGYYADPSGWGARSPPQ
500 510 520 530 540 550
490 500 510 520 530
pF1KB7 PESSDSGLGEGDSKRRRVSP-YPSSGDSSSPAGAPSPF-DKEAEGQFYNYFPN
.. :: : : .:.:. ... .. .:. .::::
NP_006 YCGTKSG---------SVLPCWPNSAAAAARMAGANPYLGEEAEGLAAERSPLPPGAAED
560 570 580 590 600
NP_006 AKPKDLSDSSWIETPSSIKSIDSSDSGIYEQAKRRRISPADTPVSESSSPLKSEVLAQRD
610 620 630 640 650 660
>>XP_005265567 (OMIM: 604615) eomesodermin homolog isofo (515 aa)
initn: 1082 init1: 992 opt: 1096 Z-score: 673.7 bits: 134.3 E(92320): 9.4e-31
Smith-Waterman score: 1100; 55.1% identity (71.0% similar) in 334 aa overlap (34-342:143-474)
10 20 30 40 50
pF1KB7 VEPGCGDMLTGTEPMPGSDEGRAPGADPQHRYFYPEPGAQDAD----------ERRGGGS
::. :: : .. . .:.
XP_005 ELPSAAAAAAAAAAAAAATARYSMDSLSSERYYLQSPGPQGSELAAPCSLFPYQAAAGAP
120 130 140 150 160 170
60 70 80 90 100
pF1KB7 LGS--PYPGGALVPA----PPSRFLGAYAYPPRPQAAGFPGAGE-SFPPPADAEGYQPGE
: : :.:: : ::. : .: : : : . :::: : ... : ::
XP_005 HGPVYPAPNGARYPYGSMLPPGGFPAAVCPPGRAQFG--PGAGAGSGAGGSSGGGGGPGT
180 190 200 210 220 230
110 120 130 140 150 160
pF1KB7 -GYAAPDPRAGLYPGPREDYALPA--GLEVSG---KLRVALNNHLLWSKFNQHQTEMIIT
:. : : ::: . . :: : : . .: : :. :: ::..::::::::
XP_005 YQYSQGAPLYGPYPGAAAAGSCGGLGGLGVPGSGFRAHVYLCNRPLWLKFHRHQTEMIIT
240 250 260 270 280 290
170 180 190 200 210 220
pF1KB7 KQGRRMFPFLSFTVAGLEPTSHYRMFVDVVLVDQHHWRYQSGKWVQCGKAEGSMPGNRLY
::::::::::::.. ::.::.:: .::.:::.: .:::.:.:::: ::::...: ::..:
XP_005 KQGRRMFPFLSFNINGLNPTAHYNVFVEVVLADPNHWRFQGGKWVTCGKADNNMQGNKMY
300 310 320 330 340 350
230 240 250 260 270 280
pF1KB7 VHPDSPNTGAHWMRQEVSFGKLKLTNNKGASNNVTQMIVLQSLHKYQPRLHIVEVNDGEP
:::.:::::.::::::.:::::::::::::.:: :::::::::::::::::::::..
XP_005 VHPESPNTGSHWMRQEISFGKLKLTNNKGANNNNTQMIVLQSLHKYQPRLHIVEVTEDGV
360 370 380 390 400 410
290 300 310 320 330
pF1KB7 EAACNASNTHIFTFQETQFIAVTAYQNAEITQLKIDNNPFAKGFRENFESMYTSV--DTS
: . :.:. :::.::::::::::::..:::::::.::::::::.:..::::. :
XP_005 EDLNEPSKTQTFTFSETQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDSMYTASENDRL
420 430 440 450 460 470
340 350 360 370 380 390
pF1KB7 IPSPPGPNCQFLGGDHYSPLLPNQYPVPSRFYPDLPGQAKDVVPQAYWLGAPRDHSYEAE
:::
XP_005 TPSPTDSPRSHQIVPGERRGGQPSPAVACHACPATWDQQTRHQFL
480 490 500 510
>>NP_005433 (OMIM: 604615) eomesodermin homolog isoform (686 aa)
initn: 1137 init1: 972 opt: 1083 Z-score: 664.4 bits: 133.0 E(92320): 3.1e-30
Smith-Waterman score: 1190; 44.3% identity (62.2% similar) in 526 aa overlap (34-512:143-655)
10 20 30 40 50
pF1KB7 VEPGCGDMLTGTEPMPGSDEGRAPGADPQHRYFYPEPGAQDAD----------ERRGGGS
::. :: : .. . .:.
NP_005 ELPSAAAAAAAAAAAAAATARYSMDSLSSERYYLQSPGPQGSELAAPCSLFPYQAAAGAP
120 130 140 150 160 170
60 70 80 90 100
pF1KB7 LGS--PYPGGALVPA----PPSRFLGAYAYPPRPQAAGFPGAGE-SFPPPADAEGYQPGE
: : :.:: : ::. : .: : : : . :::: : ... : ::
NP_005 HGPVYPAPNGARYPYGSMLPPGGFPAAVCPPGRAQFG--PGAGAGSGAGGSSGGGGGPGT
180 190 200 210 220 230
110 120 130 140 150 160
pF1KB7 -GYAAPDPRAGLYPGPREDYALPA--GLEVSG---KLRVALNNHLLWSKFNQHQTEMIIT
:. : : ::: . . :: : : . .: : :. :: ::..::::::::
NP_005 YQYSQGAPLYGPYPGAAAAGSCGGLGGLGVPGSGFRAHVYLCNRPLWLKFHRHQTEMIIT
240 250 260 270 280 290
170 180 190 200 210 220
pF1KB7 KQGRRMFPFLSFTVAGLEPTSHYRMFVDVVLVDQHHWRYQSGKWVQCGKAEGSMPGNRLY
::::::::::::.. ::.::.:: .::.:::.: .:::.:.:::: ::::...: ::..:
NP_005 KQGRRMFPFLSFNINGLNPTAHYNVFVEVVLADPNHWRFQGGKWVTCGKADNNMQGNKMY
300 310 320 330 340 350
230 240 250 260 270 280
pF1KB7 VHPDSPNTGAHWMRQEVSFGKLKLTNNKGASNNVTQMIVLQSLHKYQPRLHIVEVNDGEP
:::.:::::.::::::.:::::::::::::.:: :::::::::::::::::::::..
NP_005 VHPESPNTGSHWMRQEISFGKLKLTNNKGANNNNTQMIVLQSLHKYQPRLHIVEVTEDGV
360 370 380 390 400 410
290 300 310 320 330 340
pF1KB7 EAACNASNTHIFTFQETQFIAVTAYQNAEITQLKIDNNPFAKGFRENFESMYTSVDTSIP
: . :.:. :::.::::::::::::..:::::::.::::::::.:..: . :
NP_005 EDLNEPSKTQTFTFSETQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDSSHQIV-----
420 430 440 450 460
350 360 370 380 390
pF1KB7 SPPGP-NCQFLGGDHYSPLLPN-QYPVPSRFYPDL-----PGQAKDVV-PQAYWLGAPRD
: : . : . . . ::. .: : :. : :...:. : :: .: .
NP_005 -PGGRYGVQSFFPEPFVNTLPQARYYNGERTVPQTNGLLSPQQSEEVANPPQRWLVTPVQ
470 480 490 500 510 520
400 410 420 430 440
pF1KB7 H---------SYEAEFRAVSMKPAFLPSAPGPT---MSYYRGQEVLAPGAGWPVAPQYPP
. :::.:. . .. : . : : : ..:: . .. ::: .:
NP_005 QPGTNKLDISSYESEYTSSTLLPYGIKSLPLQTSHALGYY-PDPTFPAMAGWGGRGSYQR
530 540 550 560 570 580
450 460 470 480 490
pF1KB7 KMGPA-SWFRPMRTLPMEPGPGG-SEGRGPEDQGPPLVWTEIAP-IRP-ESSDSGLGEGD
::. . : :: : . :. . :. : : : : :. .:.:::. .
NP_005 KMAAGLPWTS--RTSPTVFSEDQLSKEKVKEEIGSS--WIETPPSIKSLDSNDSGVYTSA
590 600 610 620 630
500 510 520 530
pF1KB7 SKRRRVSPYPSSGDSSSPAGAPSPFDKEAEGQFYNYFPN
::::.:: ::...:
NP_005 CKRRRLSPSNSSNENSPSIKCEDINAEEYSKDTSKGMGGYYAFYTTP
640 650 660 670 680
>>NP_001265112 (OMIM: 604615) eomesodermin homolog isofo (410 aa)
initn: 953 init1: 878 opt: 935 Z-score: 578.9 bits: 116.4 E(92320): 1.8e-25
Smith-Waterman score: 1011; 47.7% identity (68.2% similar) in 384 aa overlap (166-512:1-379)
140 150 160 170 180 190
pF1KB7 KLRVALNNHLLWSKFNQHQTEMIITKQGRRMFPFLSFTVAGLEPTSHYRMFVDVVLVDQH
:::::::.. ::.::.:: .::.:::.: .
NP_001 MFPFLSFNINGLNPTAHYNVFVEVVLADPN
10 20 30
200 210 220 230 240 250
pF1KB7 HWRYQSGKWVQCGKAEGSMPGNRLYVHPDSPNTGAHWMRQEVSFGKLKLTNNKGASNNVT
:::.:.:::: ::::...: ::..::::.:::::.::::::.:::::::::::::.:: :
NP_001 HWRFQGGKWVTCGKADNNMQGNKMYVHPESPNTGSHWMRQEISFGKLKLTNNKGANNNNT
40 50 60 70 80 90
260 270 280 290 300 310
pF1KB7 QMIVLQSLHKYQPRLHIVEVNDGEPEAACNASNTHIFTFQETQFIAVTAYQNAEITQLKI
::::::::::::::::::::.. : . :.:. :::.::::::::::::..::::::
NP_001 QMIVLQSLHKYQPRLHIVEVTEDGVEDLNEPSKTQTFTFSETQFIAVTAYQNTDITQLKI
100 110 120 130 140 150
320 330 340 350 360
pF1KB7 DNNPFAKGFRENFESMYTSV--DTSIPSPP-GPNC-QFLGGDHYS--PLLPNQY--PVP-
:.::::::::.:..::::. : ::: .: :.. : .:. ..:. . .:
NP_001 DHNPFAKGFRDNYDSMYTASENDRLTPSPTDSPRSHQIVPGGRYGVQSFFPEPFVNTLPQ
160 170 180 190 200 210
370 380 390 400
pF1KB7 SRFY------PDL-----PGQAKDVV-PQAYWLGAPRDH---------SYEAEFRAVSMK
.:.: :. : :...:. : :: .: .. :::.:. . ..
NP_001 ARYYNGERTVPQTNGLLSPQQSEEVANPPQRWLVTPVQQPGTNKLDISSYESEYTSSTLL
220 230 240 250 260 270
410 420 430 440 450 460
pF1KB7 PAFLPSAPGPT---MSYYRGQEVLAPGAGWPVAPQYPPKMGPA-SWFRPMRTLPMEPGPG
: . : : : ..:: . .. ::: .: ::. . : :: : .
NP_001 PYGIKSLPLQTSHALGYY-PDPTFPAMAGWGGRGSYQRKMAAGLPWTS--RTSPTVFSED
280 290 300 310 320
470 480 490 500 510
pF1KB7 G-SEGRGPEDQGPPLVWTEIAP-IRP-ESSDSGLGEGDSKRRRVSPYPSSGDSSSPAGAP
:. . :. : : : : :. .:.:::. . ::::.:: ::...:
NP_001 QLSKEKVKEEIGSS--WIETPPSIKSLDSNDSGVYTSACKRRRLSPSNSSNENSPSIKCE
330 340 350 360 370 380
520 530
pF1KB7 SPFDKEAEGQFYNYFPN
NP_001 DINAEEYSKDTSKGMGGYYAFYTTP
390 400 410
>>XP_011523797 (OMIM: 147891,601719) T-box transcription (417 aa)
initn: 692 init1: 268 opt: 716 Z-score: 448.2 bits: 92.3 E(92320): 3.4e-18
Smith-Waterman score: 731; 46.0% identity (67.8% similar) in 289 aa overlap (48-325:37-313)
20 30 40 50 60 70
pF1KB7 MPGSDEGRAPGADPQHRYFYPEPGAQDADERRGGGSLGS-PYPGGALVPAPPSRFLGAYA
:: ...: : :: : :. : : .
XP_011 RLAPAPFYLLGCTWLVYFARSWESKSKPGMRRPLNKMGERPEPGDA--PGGP----GESG
10 20 30 40 50 60
80 90 100 110 120
pF1KB7 YPPRPQAAGFPGAGESFPPPADAEGYQ-----PGEGYAAPDPRA---GLYPGPREDYALP
: :. . :.: :. : : : . ::: . : ::: : .
XP_011 KKEMLQDKGLSESEEAFRAPGPALGEASAANAPEPALAAPGLSGAALGSPPGPGADVVAA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 AGLEVSGK-LRVALNNHLLWSKFNQHQTEMIITKQGRRMFPFLSFTVAGLEPTSHYRMFV
:. : . . ..:.:... ::.::.. ::::::: :::::: . :.:..: ..: ...
XP_011 AAAEQTIENIKVGLHEKELWKKFHEAGTEMIITKAGRRMFPSYKVKVTGMNPKTKYILLI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 DVVLVDQHHWRYQSGKWVQCGKAEGSMPGNRLYVHPDSPNTGAHWMRQEVSFGKLKLTNN
:.: .:.:.... ..::. :::: .::: ::::::::: :::::::: ::: :::::::
XP_011 DIVPADDHRYKFCDNKWMVAGKAEPAMPG-RLYVHPDSPATGAHWMRQLVSFQKLKLTNN
190 200 210 220 230
250 260 270 280 290 300
pF1KB7 KGASNNVTQMIVLQSLHKYQPRLHIVEVNDGEPEAACN-ASNTHIFTFQETQFIAVTAYQ
. . :.:.:.::::::::::...... .. : : ::.: ::.::.::.::
XP_011 HL---DPFGHIILNSMHKYQPRLHIVKADENNAFGSKNTAFCTHVF--PETSFISVTSYQ
240 250 260 270 280 290
310 320 330 340 350 360
pF1KB7 NAEITQLKIDNNPFAKGFRENFESMYTSVDTSIPSPPGPNCQFLGGDHYSPLLPNQYPVP
: .::::::.:::::::::
XP_011 NHKITQLKIENNPFAKGFRGSDDSDLRVARLQSKEYPVISKSIMRQRLISPQLSATPDVG
300 310 320 330 340 350
>>XP_016884414 (OMIM: 187500,188400,192430,217095,602054 (545 aa)
initn: 643 init1: 253 opt: 717 Z-score: 447.3 bits: 92.5 E(92320): 3.8e-18
Smith-Waterman score: 726; 33.1% identity (55.0% similar) in 522 aa overlap (27-517:45-539)
10 20 30 40 50
pF1KB7 MGIVEPGCGDMLTGTEPMPGSDEGRAPGADPQHRYFYPEPGAQDADERRGGGSLGS
::. : .: ..: . .:::.
XP_016 SIASLVAAEAAERTAHQGSGSSDRVKLRWLPGS-PAGMHFSTVTRDMEAFTASSLSSLGA
20 30 40 50 60 70
60 70 80 90 100 110
pF1KB7 P--YPGGALVPAPPSRFLGAYAYPPR--PQAAGFPGAGESFPPPADAEGYQPGEGYAAPD
.::.: : : ::: : ::. ::: . ::: : . :. : :.
XP_016 AGGFPGAASPGADPYGPREPPPPPPRYDPCAAAAPGA-PGPPPPPHAYPFAPAAGAATSA
80 90 100 110 120 130
120 130 140 150 160
pF1KB7 PRAGLYPGPREDYALPAGLEVSGKL---RVALNNHLLWSKFNQHQTEMIITKQGRRMFPF
:: : : .. ..:. : :. . ::..::: ::::.:: ::::::
XP_016 AAEPEGPGASCAAAAKAPVKKNAKVAGVSVQLEMKALWDEFNQLGTEMIVTKAGRRMFPT
140 150 160 170 180 190
170 180 190 200 210 220
pF1KB7 LSFTVAGLEPTSHYRMFVDVVLVDQHHWRY--QSGKWVQCGKAEGSMPGNRLYVHPDSPN
.. . :..: . : ...: : ::....:: .:..:. :::. . :: :.. :::::
XP_016 FQVKLFGMDPMADYMLLMDFVPVDDKRYRYAFHSSSWLVAGKADPATPG-RVHYHPDSPA
200 210 220 230 240 250
230 240 250 260 270 280
pF1KB7 TGAHWMRQEVSFGKLKLTNNKGASNNVTQMIVLQSLHKYQPRLHIVEVNDGEPEAACNAS
::.::.: ::: ::::::: .:. :.:.:.:.::::.:.: :. .
XP_016 KGAQWMKQIVSFDKLKLTNNLLDDNG---HIILNSMHRYQPRFHVVYVDPRKDSEKYAEE
260 270 280 290 300
290 300 310 320 330 340
pF1KB7 NTHIFTFQETQFIAVTAYQNAEITQLKIDNNPFAKGFRENFESMYTSVDTSIPSPPGPNC
: . :.:.::.: ::::::: .:::::: .::::::::. . : :.
XP_016 NFKTFVFEETRFTAVTAYQNHRITQLKIASNPFAKGFRD-------CDPEDWPRNHRPGA
310 320 330 340 350 360
350 360 370 380 390 400
pF1KB7 QFLGGDHYSPLLPNQYPVPSRFYPDLPGQAKDVVPQAYWL----GAPR---DHSYEAEFR
: .: . .. :: : :. : ::.. . :.: : .. ..
XP_016 LPL----MSAFARSRNPVASPTQPS--GTEKDAAEARREFQRDAGGPAVLGDPAHPPQLL
370 380 390 400 410
410 420 430 440
pF1KB7 AVSMKPAF-----------LPSAPGPTMSYYRGQEVL-APGAGWPVAPQYPPKMGPASWF
: ..:.. ::.::: : . : ::::. :. .. : ::. .
XP_016 ARVLSPSLPGAGGAGGLVPLPGAPGGRPSPPNPELRLEAPGASEPL--HHHPYKYPAAAY
420 430 440 450 460 470
450 460 470 480 490 500
pF1KB7 RPMRTLPMEPGP---GGSEGRGPEDQGPPLVWTEIAPIRPESSDSGLGEGDSKRRRVSPY
. .:.: : .:.: . .. : . :. : .. .. . . . .. :
XP_016 DHYLGAKSRPAPYPLPGLRGHGYHPHAHP--HHHHHPVSPAAAAAAAAAAAAAA--ANMY
480 490 500 510 520
510 520 530
pF1KB7 PSSGDSSSPAGAPSPFDKEAEGQFYNYFPN
:.: ..: :.
XP_016 SSAG--AAPPGSYDYCPR
530 540
>>NP_542378 (OMIM: 187500,188400,192430,217095,602054) T (495 aa)
initn: 643 init1: 253 opt: 716 Z-score: 447.2 bits: 92.3 E(92320): 3.9e-18
Smith-Waterman score: 725; 33.8% identity (54.8% similar) in 500 aa overlap (51-517:25-489)
30 40 50 60 70
pF1KB7 SDEGRAPGADPQHRYFYPEPGAQDADERRGGGSLGSPYPG----GALVPAPPSRFLGAYA
:: :. :: : : ::
NP_542 MHFSTVTRDMEAFTASSLSSLGAAGGFPGAASPGADPYGPREPPPP--------
10 20 30 40
80 90 100 110 120 130
pF1KB7 YPPR--PQAAGFPGAGESFPPPADAEGYQPGEGYAAPDPRAGLYPGPREDYALPAGLEVS
::: : ::. ::: . ::: : . :. : :. :: : : .. .
NP_542 -PPRYDPCAAAAPGA-PGPPPPPHAYPFAPAAGAATSAAAEPEGPGASCAAAAKAPVKKN
50 60 70 80 90 100
140 150 160 170 180 190
pF1KB7 GKL---RVALNNHLLWSKFNQHQTEMIITKQGRRMFPFLSFTVAGLEPTSHYRMFVDVVL
.:. : :. . ::..::: ::::.:: :::::: .. . :..: . : ...: :
NP_542 AKVAGVSVQLEMKALWDEFNQLGTEMIVTKAGRRMFPTFQVKLFGMDPMADYMLLMDFVP
110 120 130 140 150 160
200 210 220 230 240
pF1KB7 VDQHHWRY--QSGKWVQCGKAEGSMPGNRLYVHPDSPNTGAHWMRQEVSFGKLKLTNNKG
::....:: .:..:. :::. . :: :.. ::::: ::.::.: ::: :::::::
NP_542 VDDKRYRYAFHSSSWLVAGKADPATPG-RVHYHPDSPAKGAQWMKQIVSFDKLKLTNNLL
170 180 190 200 210 220
250 260 270 280 290 300
pF1KB7 ASNNVTQMIVLQSLHKYQPRLHIVEVNDGEPEAACNASNTHIFTFQETQFIAVTAYQNAE
.:. :.:.:.:.::::.:.: :. . : . :.:.::.: ::::::: .
NP_542 DDNG---HIILNSMHRYQPRFHVVYVDPRKDSEKYAEENFKTFVFEETRFTAVTAYQNHR
230 240 250 260 270 280
310 320 330 340 350 360
pF1KB7 ITQLKIDNNPFAKGFRENFESMYTSVDTSIPSPPGPNCQFLGGDHYSPLLPNQYPVPSRF
:::::: .::::::::. . : :. : .: . .. :: :
NP_542 ITQLKIASNPFAKGFRD-------CDPEDWPRNHRPGALPL----MSAFARSRNPVASPT
290 300 310 320
370 380 390 400 410
pF1KB7 YPDLPGQAKDVVPQAYWL----GAPR---DHSYEAEFRAVSMKPAF-----------LPS
:. : ::.. . :.: : .. .. : ..:.. ::.
NP_542 QPS--GTEKDAAEARREFQRDAGGPAVLGDPAHPPQLLARVLSPSLPGAGGAGGLVPLPG
330 340 350 360 370 380
420 430 440 450 460
pF1KB7 APGPTMSYYRGQEVL-APGAGWPVAPQYPPKMGPASWFRPMRTLPMEPGP---GGSEGRG
::: : . : ::::. :. .. : ::. . . .:.: : .:.:
NP_542 APGGRPSPPNPELRLEAPGASEPL--HHHPYKYPAAAYDHYLGAKSRPAPYPLPGLRGHG
390 400 410 420 430 440
470 480 490 500 510 520
pF1KB7 PEDQGPPLVWTEIAPIRPESSDSGLGEGDSKRRRVSPYPSSGDSSSPAGAPSPFDKEAEG
. .. : . :. : .. .. . . . . : :.: ..: :.
NP_542 YHPHAHPH--HHHHPVSPAAAAAAAAAAAAAAANM--YSSAG--AAPPGSYDYCPR
450 460 470 480 490
530
pF1KB7 QFYNYFPN
>>XP_016884415 (OMIM: 187500,188400,192430,217095,602054 (495 aa)
initn: 643 init1: 253 opt: 716 Z-score: 447.2 bits: 92.3 E(92320): 3.9e-18
Smith-Waterman score: 725; 33.8% identity (54.8% similar) in 500 aa overlap (51-517:25-489)
30 40 50 60 70
pF1KB7 SDEGRAPGADPQHRYFYPEPGAQDADERRGGGSLGSPYPG----GALVPAPPSRFLGAYA
:: :. :: : : ::
XP_016 MHFSTVTRDMEAFTASSLSSLGAAGGFPGAASPGADPYGPREPPPP--------
10 20 30 40
80 90 100 110 120 130
pF1KB7 YPPR--PQAAGFPGAGESFPPPADAEGYQPGEGYAAPDPRAGLYPGPREDYALPAGLEVS
::: : ::. ::: . ::: : . :. : :. :: : : .. .
XP_016 -PPRYDPCAAAAPGA-PGPPPPPHAYPFAPAAGAATSAAAEPEGPGASCAAAAKAPVKKN
50 60 70 80 90 100
140 150 160 170 180 190
pF1KB7 GKL---RVALNNHLLWSKFNQHQTEMIITKQGRRMFPFLSFTVAGLEPTSHYRMFVDVVL
.:. : :. . ::..::: ::::.:: :::::: .. . :..: . : ...: :
XP_016 AKVAGVSVQLEMKALWDEFNQLGTEMIVTKAGRRMFPTFQVKLFGMDPMADYMLLMDFVP
110 120 130 140 150 160
200 210 220 230 240
pF1KB7 VDQHHWRY--QSGKWVQCGKAEGSMPGNRLYVHPDSPNTGAHWMRQEVSFGKLKLTNNKG
::....:: .:..:. :::. . :: :.. ::::: ::.::.: ::: :::::::
XP_016 VDDKRYRYAFHSSSWLVAGKADPATPG-RVHYHPDSPAKGAQWMKQIVSFDKLKLTNNLL
170 180 190 200 210 220
250 260 270 280 290 300
pF1KB7 ASNNVTQMIVLQSLHKYQPRLHIVEVNDGEPEAACNASNTHIFTFQETQFIAVTAYQNAE
.:. :.:.:.:.::::.:.: :. . : . :.:.::.: ::::::: .
XP_016 DDNG---HIILNSMHRYQPRFHVVYVDPRKDSEKYAEENFKTFVFEETRFTAVTAYQNHR
230 240 250 260 270 280
310 320 330 340 350 360
pF1KB7 ITQLKIDNNPFAKGFRENFESMYTSVDTSIPSPPGPNCQFLGGDHYSPLLPNQYPVPSRF
:::::: .::::::::. . : :. : .: . .. :: :
XP_016 ITQLKIASNPFAKGFRD-------CDPEDWPRNHRPGALPL----MSAFARSRNPVASPT
290 300 310 320
370 380 390 400 410
pF1KB7 YPDLPGQAKDVVPQAYWL----GAPR---DHSYEAEFRAVSMKPAF-----------LPS
:. : ::.. . :.: : .. .. : ..:.. ::.
XP_016 QPS--GTEKDAAEARREFQRDAGGPAVLGDPAHPPQLLARVLSPSLPGAGGAGGLVPLPG
330 340 350 360 370 380
420 430 440 450 460
pF1KB7 APGPTMSYYRGQEVL-APGAGWPVAPQYPPKMGPASWFRPMRTLPMEPGP---GGSEGRG
::: : . : ::::. :. .. : ::. . . .:.: : .:.:
XP_016 APGGRPSPPNPELRLEAPGASEPL--HHHPYKYPAAAYDHYLGAKSRPAPYPLPGLRGHG
390 400 410 420 430 440
470 480 490 500 510 520
pF1KB7 PEDQGPPLVWTEIAPIRPESSDSGLGEGDSKRRRVSPYPSSGDSSSPAGAPSPFDKEAEG
. .. : . :. : .. .. . . . . : :.: ..: :.
XP_016 YHPHAHPH--HHHHPVSPAAAAAAAAAAAAAAANM--YSSAG--AAPPGSYDYCPR
450 460 470 480 490
530
pF1KB7 QFYNYFPN
535 residues in 1 query sequences
64369986 residues in 92320 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Oct 24 21:47:18 2019 done: Thu Oct 24 21:47:19 2019
Total Scan time: 5.510 Total Display time: 0.090
Function used was FASTA [36.3.4 Apr, 2011]