FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1893, 422 aa 1>>>pF1KE1893 422 - 422 aa - 422 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.0241+/-0.000449; mu= 13.6317+/- 0.028 mean_var=75.5860+/-14.623, 0's: 0 Z-trim(109.6): 48 B-trim: 28 in 1/54 Lambda= 0.147521 statistics sampled from 17844 (17859) to 17844 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.562), E-opt: 0.2 (0.209), width: 16 Scan time: 8.260 The best scores are: opt bits E(85289) NP_002806 (OMIM: 604449) 26S proteasome non-ATPase ( 422) 2637 571.1 1.8e-162 NP_001257411 (OMIM: 604449) 26S proteasome non-ATP ( 422) 2637 571.1 1.8e-162 NP_004227 (OMIM: 604508) COP9 signalosome complex ( 443) 395 94.0 8.3e-19 NP_001137359 (OMIM: 604508) COP9 signalosome compl ( 450) 386 92.0 3.2e-18 >>NP_002806 (OMIM: 604449) 26S proteasome non-ATPase reg (422 aa) initn: 2637 init1: 2637 opt: 2637 Z-score: 3037.7 bits: 571.1 E(85289): 1.8e-162 Smith-Waterman score: 2637; 100.0% identity (100.0% similar) in 422 aa overlap (1-422:1-422) 10 20 30 40 50 60 pF1KE1 MAAAAVVEFQRAQSLLSTDREASIDILHSIVKRDIQENDEEAVQVKEQSILELGSLLAKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MAAAAVVEFQRAQSLLSTDREASIDILHSIVKRDIQENDEEAVQVKEQSILELGSLLAKT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 GQAAELGGLLKYVRPFLNSISKAKAARLVRSLLDLFLDMEAATGQEVELCLECIEWAKSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 GQAAELGGLLKYVRPFLNSISKAKAARLVRSLLDLFLDMEAATGQEVELCLECIEWAKSE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 KRTFLRQALEARLVSLYFDTKRYQEALHLGSQLLRELKKMDDKALLVEVQLLESKTYHAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 KRTFLRQALEARLVSLYFDTKRYQEALHLGSQLLRELKKMDDKALLVEVQLLESKTYHAL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 SNLPKARAALTSARTTANAIYCPPKLQATLDMQSGIIHAAEEKDWKTAYSYFYEAFEGYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SNLPKARAALTSARTTANAIYCPPKLQATLDMQSGIIHAAEEKDWKTAYSYFYEAFEGYD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 SIDSPKAITSLKYMLLCKIMLNTPEDVQALVSGKLALRYAGRQTEALKCVAQASKNRSLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SIDSPKAITSLKYMLLCKIMLNTPEDVQALVSGKLALRYAGRQTEALKCVAQASKNRSLA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 DFEKALTDYRAELRDDPIISTHLAKLYDNLLEQNLIRVIEPFSRVQIEHISSLIKLSKAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 DFEKALTDYRAELRDDPIISTHLAKLYDNLLEQNLIRVIEPFSRVQIEHISSLIKLSKAD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 VERKLSQMILDKKFHGILDQGEGVLIIFDEPPVDKTYEAALETIQNMSKVVDSLYNKAKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 VERKLSQMILDKKFHGILDQGEGVLIIFDEPPVDKTYEAALETIQNMSKVVDSLYNKAKK 370 380 390 400 410 420 pF1KE1 LT :: NP_002 LT >>NP_001257411 (OMIM: 604449) 26S proteasome non-ATPase (422 aa) initn: 2637 init1: 2637 opt: 2637 Z-score: 3037.7 bits: 571.1 E(85289): 1.8e-162 Smith-Waterman score: 2637; 100.0% identity (100.0% similar) in 422 aa overlap (1-422:1-422) 10 20 30 40 50 60 pF1KE1 MAAAAVVEFQRAQSLLSTDREASIDILHSIVKRDIQENDEEAVQVKEQSILELGSLLAKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAAAAVVEFQRAQSLLSTDREASIDILHSIVKRDIQENDEEAVQVKEQSILELGSLLAKT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 GQAAELGGLLKYVRPFLNSISKAKAARLVRSLLDLFLDMEAATGQEVELCLECIEWAKSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GQAAELGGLLKYVRPFLNSISKAKAARLVRSLLDLFLDMEAATGQEVELCLECIEWAKSE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 KRTFLRQALEARLVSLYFDTKRYQEALHLGSQLLRELKKMDDKALLVEVQLLESKTYHAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KRTFLRQALEARLVSLYFDTKRYQEALHLGSQLLRELKKMDDKALLVEVQLLESKTYHAL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 SNLPKARAALTSARTTANAIYCPPKLQATLDMQSGIIHAAEEKDWKTAYSYFYEAFEGYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SNLPKARAALTSARTTANAIYCPPKLQATLDMQSGIIHAAEEKDWKTAYSYFYEAFEGYD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 SIDSPKAITSLKYMLLCKIMLNTPEDVQALVSGKLALRYAGRQTEALKCVAQASKNRSLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SIDSPKAITSLKYMLLCKIMLNTPEDVQALVSGKLALRYAGRQTEALKCVAQASKNRSLA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 DFEKALTDYRAELRDDPIISTHLAKLYDNLLEQNLIRVIEPFSRVQIEHISSLIKLSKAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DFEKALTDYRAELRDDPIISTHLAKLYDNLLEQNLIRVIEPFSRVQIEHISSLIKLSKAD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 VERKLSQMILDKKFHGILDQGEGVLIIFDEPPVDKTYEAALETIQNMSKVVDSLYNKAKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VERKLSQMILDKKFHGILDQGEGVLIIFDEPPVDKTYEAALETIQNMSKVVDSLYNKAKK 370 380 390 400 410 420 pF1KE1 LT :: NP_001 LT >>NP_004227 (OMIM: 604508) COP9 signalosome complex subu (443 aa) initn: 302 init1: 229 opt: 395 Z-score: 458.6 bits: 94.0 E(85289): 8.3e-19 Smith-Waterman score: 395; 26.0% identity (57.9% similar) in 385 aa overlap (8-380:35-404) 10 20 30 pF1KE1 MAAAAVVEFQRAQSLLSTDREASIDILHSIVKRDIQE .. ...: : .:... ...... . : NP_004 EDDFMCDDEEDYDLEYSEDSNSEPNVDLENQYYNSKALKEDDPKAALSSFQKVLELE-GE 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE1 NDEEAVQVKEQSILELGSLLAKTGQAAELGGLLKYVRPFLNSISKAKAARLVRSLLDLF- . : . .. .: : .: . . :: :.: ..... . . . :.:: . NP_004 KGEWGFKALKQMIKINFKLTNFPEMMNRYKQLLTYIR---SAVTRNYSEKSINSILDYIS 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE1 LDMEAATGQEV-ELCLECIEWAKSEKRTFLRQALEARLVSLYFDTKRYQEALHLGSQLLR . . :: : :: .. ::... : ...: .::.. ..: . .. :: . NP_004 TSKQMDLLQEFYETTLEALKDAKNDRLWF---KTNTKLGKLYLEREEYGKLQKILRQLHQ 130 140 150 160 170 160 170 180 190 200 pF1KE1 ELKKMDDK------ALLVEVQLLESKTYHALSNLPKARAALTSARTTANAIYCP-PKLQA . : . . :.:. :: . : : .: : .: .. .:: : : ... NP_004 SCQTDDGEDDLKKGTQLLEIYALEIQMYTAQKNNKKLKALYEQSLHIKSAI--PHPLIMG 180 190 200 210 220 230 210 220 230 240 250 260 pF1KE1 TLDMQSGIIHAAEEKDWKTAYSYFYEAFEGYDSIDSPKAITSLKYMLLCKIMLNT---PE .. .: .: .: ... :.. :.:::..:: ::. : :::..: ...... : NP_004 VIRECGGKMHL-REGEFEKAHTDFFEAFKNYDESGSPRRTTCLKYLVLANMLMKSGINPF 240 250 260 270 280 290 270 280 290 300 310 320 pF1KE1 DVQALVSGKLALRYAGRQTEALKCVAQASKNRSLADFEKALTDYRAELRDDPIISTHLAK : : : . :. ...: .: ....::: : .... :::.: :. . NP_004 DSQEAKPYK-----NDPEILAMTNLVSAYQNNDITEFEKILKTNHSNIMDDPFIREHIEE 300 310 320 330 340 330 340 350 360 370 380 pF1KE1 LYDNLLEQNLIRVIEPFSRVQIEHISSLIKLSKADVERKLSQMILDKKFHGILDQGEGVL : :. : ::..:.:..:..: ::. .... :::: : : :::. .:: .:: NP_004 LLRNIRTQVLIKLIKPYTRIHIPFISKELNIDVADVESLLVQCILDNTIHGRIDQVNQLL 350 360 370 380 390 400 390 400 410 420 pF1KE1 IIFDEPPVDKTYEAALETIQNMSKVVDSLYNKAKKLT NP_004 ELDHQKRGGARYTALDKWTNQLNSLNQAVVSKLA 410 420 430 440 >>NP_001137359 (OMIM: 604508) COP9 signalosome complex s (450 aa) initn: 302 init1: 229 opt: 386 Z-score: 448.2 bits: 92.0 E(85289): 3.2e-18 Smith-Waterman score: 396; 26.5% identity (57.7% similar) in 388 aa overlap (4-380:49-411) 10 20 30 pF1KE1 MAAAAVVEFQRAQSLLSTDREASIDILHSIVKR ::. ::.. : . : .. :....: NP_001 EYSEDSNSEPNVDLENQYYNSKALKEDDPKAALSSFQKVLELEGEKGEWGFKALKQMIKI 20 30 40 50 60 70 40 50 60 70 80 90 pF1KE1 DIQ-ENDEEAVQVKEQSILELGSLLAKTGQAAELGGLLKYVRPFLNSISKAKAARLVRSL ... : : .. .: . . : .... . ....: :. : :: .. : . NP_001 NFKLTNFPEMMNRYKQLLTYIRSAVTRNYSEKSINSILDYI-----STSKQNSDFLCQ-- 80 90 100 110 120 130 100 110 120 130 140 150 pF1KE1 LDLFLDMEAATGQEVELCLECIEWAKSEKRTFLRQALEARLVSLYFDTKRYQEALHLGSQ .::. .. : :: .. ::... : ...: .::.. ..: . .. : NP_001 MDLLQEF-------YETTLEALKDAKNDRLWF---KTNTKLGKLYLEREEYGKLQKILRQ 140 150 160 170 180 160 170 180 190 200 pF1KE1 LLRELKKMDDK------ALLVEVQLLESKTYHALSNLPKARAALTSARTTANAIYCP-PK : . . : . . :.:. :: . : : .: : .: .. .:: : : NP_001 LHQSCQTDDGEDDLKKGTQLLEIYALEIQMYTAQKNNKKLKALYEQSLHIKSAI--PHPL 190 200 210 220 230 210 220 230 240 250 260 pF1KE1 LQATLDMQSGIIHAAEEKDWKTAYSYFYEAFEGYDSIDSPKAITSLKYMLLCKIMLNT-- ..... .: .: .: ... :.. :.:::..:: ::. : :::..: ...... NP_001 IMGVIRECGGKMHL-REGEFEKAHTDFFEAFKNYDESGSPRRTTCLKYLVLANMLMKSGI 240 250 260 270 280 290 270 280 290 300 310 320 pF1KE1 -PEDVQALVSGKLALRYAGRQTEALKCVAQASKNRSLADFEKALTDYRAELRDDPIISTH : : : : . :. ...: .: ....::: : .... :::.: : NP_001 NPFDSQEAKPYK-----NDPEILAMTNLVSAYQNNDITEFEKILKTNHSNIMDDPFIREH 300 310 320 330 340 350 330 340 350 360 370 380 pF1KE1 LAKLYDNLLEQNLIRVIEPFSRVQIEHISSLIKLSKADVERKLSQMILDKKFHGILDQGE . .: :. : ::..:.:..:..: ::. .... :::: : : :::. .:: .:: NP_001 IEELLRNIRTQVLIKLIKPYTRIHIPFISKELNIDVADVESLLVQCILDNTIHGRIDQVN 360 370 380 390 400 410 390 400 410 420 pF1KE1 GVLIIFDEPPVDKTYEAALETIQNMSKVVDSLYNKAKKLT NP_001 QLLELDHQKRGGARYTALDKWTNQLNSLNQAVVSKLA 420 430 440 450 422 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 13:53:33 2016 done: Sun Nov 6 13:53:34 2016 Total Scan time: 8.260 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]