FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3264, 643 aa 1>>>pF1KE3264 643 - 643 aa - 643 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.5593+/-0.000372; mu= 15.8961+/- 0.023 mean_var=148.7316+/-31.212, 0's: 0 Z-trim(117.9): 178 B-trim: 1618 in 2/53 Lambda= 0.105165 statistics sampled from 30103 (30393) to 30103 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.701), E-opt: 0.2 (0.356), width: 16 Scan time: 12.230 The best scores are: opt bits E(85289) NP_001135 (OMIM: 603243) E3 ubiquitin-protein liga ( 643) 4317 667.1 5.3e-191 XP_005255947 (OMIM: 603243) PREDICTED: E3 ubiquiti ( 548) 3670 568.9 1.7e-161 NP_001310440 (OMIM: 603243) E3 ubiquitin-protein l ( 548) 3670 568.9 1.7e-161 NP_001310441 (OMIM: 603243) E3 ubiquitin-protein l ( 675) 2935 457.5 7.3e-128 NP_115807 (OMIM: 608046) E3 ubiquitin-protein liga ( 616) 437 78.4 8.4e-14 NP_757385 (OMIM: 608046) E3 ubiquitin-protein liga ( 617) 437 78.4 8.4e-14 XP_011543605 (OMIM: 608046) PREDICTED: E3 ubiquiti ( 617) 437 78.4 8.4e-14 XP_016868491 (OMIM: 144700,603046) PREDICTED: E3 u ( 537) 216 44.8 0.00095 NP_009149 (OMIM: 144700,603046) E3 ubiquitin-prote ( 664) 216 44.9 0.0011 XP_005259651 (OMIM: 615177) PREDICTED: E3 ubiquiti ( 284) 198 41.8 0.004 NP_919442 (OMIM: 615177) E3 ubiquitin-protein liga ( 311) 198 41.8 0.0043 >>NP_001135 (OMIM: 603243) E3 ubiquitin-protein ligase A (643 aa) initn: 4317 init1: 4317 opt: 4317 Z-score: 3550.0 bits: 667.1 E(85289): 5.3e-191 Smith-Waterman score: 4317; 100.0% identity (100.0% similar) in 643 aa overlap (1-643:1-643) 10 20 30 40 50 60 pF1KE3 MPLLFLERFPWPSLRTYTGLSGLALLGTIISAYRALSQPEAGPGEPDQLTASLQPEPPAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPLLFLERFPWPSLRTYTGLSGLALLGTIISAYRALSQPEAGPGEPDQLTASLQPEPPAP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 ARPSAGGPRARDVAQYLLSDSLFVWVLVNTACCVLMLVAKLIQCIVFGPLRVSERQHLKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ARPSAGGPRARDVAQYLLSDSLFVWVLVNTACCVLMLVAKLIQCIVFGPLRVSERQHLKD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 KFWNFIFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKDRFEYLSFSPTTPM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KFWNFIFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKDRFEYLSFSPTTPM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 SSHGRVLSLLVAMLLSCCGLAAVCSITGYTHGMHTLAFMAAESLLVTVRTAHVILRYVIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSHGRVLSLLVAMLLSCCGLAAVCSITGYTHGMHTLAFMAAESLLVTVRTAHVILRYVIH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 LWDLNHEGTWEGKGTYVYYTDFVMELTLLSLDLMHHIHMLLFGNIWLSMASLVIFMQLRY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LWDLNHEGTWEGKGTYVYYTDFVMELTLLSLDLMHHIHMLLFGNIWLSMASLVIFMQLRY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 LFHEVQRRIRRHKNYLRVVGNMEARFAVATPEELAVNNDDCAICWDSMQAARKLPCGHLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LFHEVQRRIRRHKNYLRVVGNMEARFAVATPEELAVNNDDCAICWDSMQAARKLPCGHLF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 HNSCLRSWLEQDTSCPTCRMSLNIADNNRVREEHQGENLDENLVPVAAAEGRPRLNQHNH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HNSCLRSWLEQDTSCPTCRMSLNIADNNRVREEHQGENLDENLVPVAAAEGRPRLNQHNH 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 FFHFDGSRIASWLPSFSVEVMHTTNILGITQASNSQLNAMAHQIQEMFPQVPYHLVLQDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FFHFDGSRIASWLPSFSVEVMHTTNILGITQASNSQLNAMAHQIQEMFPQVPYHLVLQDL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 QLTRSVEITTDNILEGRIQVPFPTQRSDSIRPALNSPVERPSSDQEEGETSAQTERVPLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLTRSVEITTDNILEGRIQVPFPTQRSDSIRPALNSPVERPSSDQEEGETSAQTERVPLD 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 LSPRLEETLDFGEVEVEPSEVEDFEARGSRFSKSADERQRMLVQRKDELLQQARKRFLNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSPRLEETLDFGEVEVEPSEVEDFEARGSRFSKSADERQRMLVQRKDELLQQARKRFLNK 550 560 570 580 590 600 610 620 630 640 pF1KE3 SSEDDAASESFLPSEGASSDPVTLRRRMLAAAAERRLQKQQTS ::::::::::::::::::::::::::::::::::::::::::: NP_001 SSEDDAASESFLPSEGASSDPVTLRRRMLAAAAERRLQKQQTS 610 620 630 640 >>XP_005255947 (OMIM: 603243) PREDICTED: E3 ubiquitin-pr (548 aa) initn: 3670 init1: 3670 opt: 3670 Z-score: 3020.4 bits: 568.9 E(85289): 1.7e-161 Smith-Waterman score: 3670; 100.0% identity (100.0% similar) in 548 aa overlap (96-643:1-548) 70 80 90 100 110 120 pF1KE3 GGPRARDVAQYLLSDSLFVWVLVNTACCVLMLVAKLIQCIVFGPLRVSERQHLKDKFWNF :::::::::::::::::::::::::::::: XP_005 MLVAKLIQCIVFGPLRVSERQHLKDKFWNF 10 20 30 130 140 150 160 170 180 pF1KE3 IFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKDRFEYLSFSPTTPMSSHGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKDRFEYLSFSPTTPMSSHGR 40 50 60 70 80 90 190 200 210 220 230 240 pF1KE3 VLSLLVAMLLSCCGLAAVCSITGYTHGMHTLAFMAAESLLVTVRTAHVILRYVIHLWDLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VLSLLVAMLLSCCGLAAVCSITGYTHGMHTLAFMAAESLLVTVRTAHVILRYVIHLWDLN 100 110 120 130 140 150 250 260 270 280 290 300 pF1KE3 HEGTWEGKGTYVYYTDFVMELTLLSLDLMHHIHMLLFGNIWLSMASLVIFMQLRYLFHEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HEGTWEGKGTYVYYTDFVMELTLLSLDLMHHIHMLLFGNIWLSMASLVIFMQLRYLFHEV 160 170 180 190 200 210 310 320 330 340 350 360 pF1KE3 QRRIRRHKNYLRVVGNMEARFAVATPEELAVNNDDCAICWDSMQAARKLPCGHLFHNSCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QRRIRRHKNYLRVVGNMEARFAVATPEELAVNNDDCAICWDSMQAARKLPCGHLFHNSCL 220 230 240 250 260 270 370 380 390 400 410 420 pF1KE3 RSWLEQDTSCPTCRMSLNIADNNRVREEHQGENLDENLVPVAAAEGRPRLNQHNHFFHFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RSWLEQDTSCPTCRMSLNIADNNRVREEHQGENLDENLVPVAAAEGRPRLNQHNHFFHFD 280 290 300 310 320 330 430 440 450 460 470 480 pF1KE3 GSRIASWLPSFSVEVMHTTNILGITQASNSQLNAMAHQIQEMFPQVPYHLVLQDLQLTRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GSRIASWLPSFSVEVMHTTNILGITQASNSQLNAMAHQIQEMFPQVPYHLVLQDLQLTRS 340 350 360 370 380 390 490 500 510 520 530 540 pF1KE3 VEITTDNILEGRIQVPFPTQRSDSIRPALNSPVERPSSDQEEGETSAQTERVPLDLSPRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VEITTDNILEGRIQVPFPTQRSDSIRPALNSPVERPSSDQEEGETSAQTERVPLDLSPRL 400 410 420 430 440 450 550 560 570 580 590 600 pF1KE3 EETLDFGEVEVEPSEVEDFEARGSRFSKSADERQRMLVQRKDELLQQARKRFLNKSSEDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EETLDFGEVEVEPSEVEDFEARGSRFSKSADERQRMLVQRKDELLQQARKRFLNKSSEDD 460 470 480 490 500 510 610 620 630 640 pF1KE3 AASESFLPSEGASSDPVTLRRRMLAAAAERRLQKQQTS :::::::::::::::::::::::::::::::::::::: XP_005 AASESFLPSEGASSDPVTLRRRMLAAAAERRLQKQQTS 520 530 540 >>NP_001310440 (OMIM: 603243) E3 ubiquitin-protein ligas (548 aa) initn: 3670 init1: 3670 opt: 3670 Z-score: 3020.4 bits: 568.9 E(85289): 1.7e-161 Smith-Waterman score: 3670; 100.0% identity (100.0% similar) in 548 aa overlap (96-643:1-548) 70 80 90 100 110 120 pF1KE3 GGPRARDVAQYLLSDSLFVWVLVNTACCVLMLVAKLIQCIVFGPLRVSERQHLKDKFWNF :::::::::::::::::::::::::::::: NP_001 MLVAKLIQCIVFGPLRVSERQHLKDKFWNF 10 20 30 130 140 150 160 170 180 pF1KE3 IFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKDRFEYLSFSPTTPMSSHGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKDRFEYLSFSPTTPMSSHGR 40 50 60 70 80 90 190 200 210 220 230 240 pF1KE3 VLSLLVAMLLSCCGLAAVCSITGYTHGMHTLAFMAAESLLVTVRTAHVILRYVIHLWDLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLSLLVAMLLSCCGLAAVCSITGYTHGMHTLAFMAAESLLVTVRTAHVILRYVIHLWDLN 100 110 120 130 140 150 250 260 270 280 290 300 pF1KE3 HEGTWEGKGTYVYYTDFVMELTLLSLDLMHHIHMLLFGNIWLSMASLVIFMQLRYLFHEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HEGTWEGKGTYVYYTDFVMELTLLSLDLMHHIHMLLFGNIWLSMASLVIFMQLRYLFHEV 160 170 180 190 200 210 310 320 330 340 350 360 pF1KE3 QRRIRRHKNYLRVVGNMEARFAVATPEELAVNNDDCAICWDSMQAARKLPCGHLFHNSCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QRRIRRHKNYLRVVGNMEARFAVATPEELAVNNDDCAICWDSMQAARKLPCGHLFHNSCL 220 230 240 250 260 270 370 380 390 400 410 420 pF1KE3 RSWLEQDTSCPTCRMSLNIADNNRVREEHQGENLDENLVPVAAAEGRPRLNQHNHFFHFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RSWLEQDTSCPTCRMSLNIADNNRVREEHQGENLDENLVPVAAAEGRPRLNQHNHFFHFD 280 290 300 310 320 330 430 440 450 460 470 480 pF1KE3 GSRIASWLPSFSVEVMHTTNILGITQASNSQLNAMAHQIQEMFPQVPYHLVLQDLQLTRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSRIASWLPSFSVEVMHTTNILGITQASNSQLNAMAHQIQEMFPQVPYHLVLQDLQLTRS 340 350 360 370 380 390 490 500 510 520 530 540 pF1KE3 VEITTDNILEGRIQVPFPTQRSDSIRPALNSPVERPSSDQEEGETSAQTERVPLDLSPRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VEITTDNILEGRIQVPFPTQRSDSIRPALNSPVERPSSDQEEGETSAQTERVPLDLSPRL 400 410 420 430 440 450 550 560 570 580 590 600 pF1KE3 EETLDFGEVEVEPSEVEDFEARGSRFSKSADERQRMLVQRKDELLQQARKRFLNKSSEDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EETLDFGEVEVEPSEVEDFEARGSRFSKSADERQRMLVQRKDELLQQARKRFLNKSSEDD 460 470 480 490 500 510 610 620 630 640 pF1KE3 AASESFLPSEGASSDPVTLRRRMLAAAAERRLQKQQTS :::::::::::::::::::::::::::::::::::::: NP_001 AASESFLPSEGASSDPVTLRRRMLAAAAERRLQKQQTS 520 530 540 >>NP_001310441 (OMIM: 603243) E3 ubiquitin-protein ligas (675 aa) initn: 4303 init1: 2935 opt: 2935 Z-score: 2416.6 bits: 457.5 E(85289): 7.3e-128 Smith-Waterman score: 4243; 95.3% identity (95.3% similar) in 675 aa overlap (1-643:1-675) 10 20 30 40 50 60 pF1KE3 MPLLFLERFPWPSLRTYTGLSGLALLGTIISAYRALSQPEAGPGEPDQLTASLQPEPPAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPLLFLERFPWPSLRTYTGLSGLALLGTIISAYRALSQPEAGPGEPDQLTASLQPEPPAP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 ARPSAGGPRARDVAQYLLSDSLFVWVLVNTACCVLMLVAKLIQCIVFGPLRVSERQHLKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ARPSAGGPRARDVAQYLLSDSLFVWVLVNTACCVLMLVAKLIQCIVFGPLRVSERQHLKD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 KFWNFIFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKDRFEYLSFSPTTPM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KFWNFIFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKDRFEYLSFSPTTPM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 SSHGRVLSLLVAMLLSCCGLAAVCSITGYTHGMHTLAFMAAESLLVTVRTAHVILRYVIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSHGRVLSLLVAMLLSCCGLAAVCSITGYTHGMHTLAFMAAESLLVTVRTAHVILRYVIH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 LWDLNHEGTWEGKGTYVYYTDFVMELTLLSLDLMHHIHMLLFGNIWLSMASLVIFMQLRY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LWDLNHEGTWEGKGTYVYYTDFVMELTLLSLDLMHHIHMLLFGNIWLSMASLVIFMQLRY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 LFHEVQRRIRRHKNYLRVVGNMEARFAVATPEELAVNNDDCAICWDSMQAARKLPCGHLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LFHEVQRRIRRHKNYLRVVGNMEARFAVATPEELAVNNDDCAICWDSMQAARKLPCGHLF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 HNSCLRSWLEQDTSCPTCRMSLNIADNNRVREEHQGENLDENLVPVAAAEGRPRLNQHNH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HNSCLRSWLEQDTSCPTCRMSLNIADNNRVREEHQGENLDENLVPVAAAEGRPRLNQHNH 370 380 390 400 410 420 430 440 pF1KE3 FFHFDG--------------------------------SRIASWLPSFSVEVMHTTNILG :::::: :::::::::::::::::::::: NP_001 FFHFDGDDSSMRVTAPEDVPVGQEVEVVDSDTDAPDLWSRIASWLPSFSVEVMHTTNILG 430 440 450 460 470 480 450 460 470 480 490 500 pF1KE3 ITQASNSQLNAMAHQIQEMFPQVPYHLVLQDLQLTRSVEITTDNILEGRIQVPFPTQRSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ITQASNSQLNAMAHQIQEMFPQVPYHLVLQDLQLTRSVEITTDNILEGRIQVPFPTQRSD 490 500 510 520 530 540 510 520 530 540 550 560 pF1KE3 SIRPALNSPVERPSSDQEEGETSAQTERVPLDLSPRLEETLDFGEVEVEPSEVEDFEARG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SIRPALNSPVERPSSDQEEGETSAQTERVPLDLSPRLEETLDFGEVEVEPSEVEDFEARG 550 560 570 580 590 600 570 580 590 600 610 620 pF1KE3 SRFSKSADERQRMLVQRKDELLQQARKRFLNKSSEDDAASESFLPSEGASSDPVTLRRRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SRFSKSADERQRMLVQRKDELLQQARKRFLNKSSEDDAASESFLPSEGASSDPVTLRRRM 610 620 630 640 650 660 630 640 pF1KE3 LAAAAERRLQKQQTS ::::::::::::::: NP_001 LAAAAERRLQKQQTS 670 >>NP_115807 (OMIM: 608046) E3 ubiquitin-protein ligase s (616 aa) initn: 444 init1: 180 opt: 437 Z-score: 368.8 bits: 78.4 E(85289): 8.4e-14 Smith-Waterman score: 438; 28.8% identity (58.8% similar) in 320 aa overlap (76-382:35-333) 50 60 70 80 90 100 pF1KE3 PDQLTASLQPEPPAPARPSAGGPRARDVAQYLLSDSLFVWVLVNTACCVLMLVAKLIQCI :: ..: . :: : ...:..:.. . NP_115 AVMMAASLALTGAVVAHAYYLKHQFYPTVVYLTKSSPSMAVLYIQAFVLVFLLGKVMGKV 10 20 30 40 50 60 110 120 130 140 150 160 pF1KE3 VFGPLRVSERQHLKDKFWNFIFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLC :: ::..: .:: .. : . . . : :. . . : :. :.::. . : NP_115 FFGQLRAAEMEHLLERSW-YAVTETCLAFTVFRDDFSPRFVAL---FTLLLFLKCFHWLA 70 80 90 100 110 120 170 180 190 200 210 pF1KE3 KDRFEYLSFSPTTPMSSHGRVLSLLVAMLLSCCGLAAVCSITGYTHGMHT------LAFM .:: ... ::. : :..::. . :. .. :.. : :.: NP_115 EDRVDFMERSPNISWLFHCRIVSLMFLL-----GILDFLFVSHAYHSILTRGASVQLVFG 130 140 150 160 170 220 230 240 250 260 270 pF1KE3 AAESLLVTVRTAHVILRYVIHLWDLNHEGTWEGKGTYVYYTD----FVMELTLLS-LDLM ..:.:. . ....::.: ::. :. :..:..:. ::. :. : .. . .: NP_115 FEYAILMTM-VLTIFIKYVLHSVDLQSENPWDNKAVYMLYTELFTGFIKVLLYMAFMTIM 180 190 200 210 220 230 280 290 300 310 320 330 pF1KE3 HHIHML-LFGNIWLSMASLVIFMQLRYLFHEVQRRIRRHKNYLRVVGNMEARFAVATPEE ..: . :: : ... .: . . : : . :.. ::.. . ::::: NP_115 IKVHTFPLF-------AIRPMYLAMRQFKKAVTDAIMSR----RAIRNMNTLYPDATPEE 240 250 260 270 280 340 350 360 370 380 390 pF1KE3 LAVNNDDCAICWDSM-QAARKLPCGHLFHNSCLRSWLEQDTSCPTCRMSLNIADNNRVRE : . .. : :: . : .:..:::.:.::.::::::.... .::::::.. NP_115 LQAMDNVCIICREEMVTGAKRLPCNHIFHTSCLRSWFQRQQTCPTCRMDVLRASLPAQSP 290 300 310 320 330 340 400 410 420 430 440 450 pF1KE3 EHQGENLDENLVPVAAAEGRPRLNQHNHFFHFDGSRIASWLPSFSVEVMHTTNILGITQA NP_115 PPPEPADQGPPPAPHPPPLLPQPPNFPQGLLPPFPPGMFPLWPPMGPFPPVPPPPSSGEA 350 360 370 380 390 400 >>NP_757385 (OMIM: 608046) E3 ubiquitin-protein ligase s (617 aa) initn: 433 init1: 169 opt: 437 Z-score: 368.8 bits: 78.4 E(85289): 8.4e-14 Smith-Waterman score: 438; 28.8% identity (58.8% similar) in 320 aa overlap (76-382:35-333) 50 60 70 80 90 100 pF1KE3 PDQLTASLQPEPPAPARPSAGGPRARDVAQYLLSDSLFVWVLVNTACCVLMLVAKLIQCI :: ..: . :: : ...:..:.. . NP_757 AVMMAASLALTGAVVAHAYYLKHQFYPTVVYLTKSSPSMAVLYIQAFVLVFLLGKVMGKV 10 20 30 40 50 60 110 120 130 140 150 160 pF1KE3 VFGPLRVSERQHLKDKFWNFIFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLC :: ::..: .:: .. : . . . : :. . . : :. :.::. . : NP_757 FFGQLRAAEMEHLLERSW-YAVTETCLAFTVFRDDFSPRFVAL---FTLLLFLKCFHWLA 70 80 90 100 110 120 170 180 190 200 210 pF1KE3 KDRFEYLSFSPTTPMSSHGRVLSLLVAMLLSCCGLAAVCSITGYTHGMHT------LAFM .:: ... ::. : :..::. . :. .. :.. : :.: NP_757 EDRVDFMERSPNISWLFHCRIVSLMFLL-----GILDFLFVSHAYHSILTRGASVQLVFG 130 140 150 160 170 220 230 240 250 260 270 pF1KE3 AAESLLVTVRTAHVILRYVIHLWDLNHEGTWEGKGTYVYYTD----FVMELTLLS-LDLM ..:.:. . ....::.: ::. :. :..:..:. ::. :. : .. . .: NP_757 FEYAILMTM-VLTIFIKYVLHSVDLQSENPWDNKAVYMLYTELFTGFIKVLLYMAFMTIM 180 190 200 210 220 230 280 290 300 310 320 330 pF1KE3 HHIHML-LFGNIWLSMASLVIFMQLRYLFHEVQRRIRRHKNYLRVVGNMEARFAVATPEE ..: . :: : ... .: . . : : . :.. ::.. . ::::: NP_757 IKVHTFPLF-------AIRPMYLAMRQFKKAVTDAIMSR----RAIRNMNTLYPDATPEE 240 250 260 270 280 340 350 360 370 380 390 pF1KE3 LAVNNDDCAICWDSM-QAARKLPCGHLFHNSCLRSWLEQDTSCPTCRMSLNIADNNRVRE : . .. : :: . : .:..:::.:.::.::::::.... .::::::.. NP_757 LQAMDNVCIICREEMVTGAKRLPCNHIFHTSCLRSWFQRQQTCPTCRMDVLRASLPAQSP 290 300 310 320 330 340 400 410 420 430 440 450 pF1KE3 EHQGENLDENLVPVAAAEGRPRLNQHNHFFHFDGSRIASWLPSFSVEVMHTTNILGITQA NP_757 PPPEPADQGPPPAPHPPPLLPQPPNFPQGLLPPFPPGMFPLWPPMGPFPPVPPPPSSGEA 350 360 370 380 390 400 >>XP_011543605 (OMIM: 608046) PREDICTED: E3 ubiquitin-pr (617 aa) initn: 433 init1: 169 opt: 437 Z-score: 368.8 bits: 78.4 E(85289): 8.4e-14 Smith-Waterman score: 438; 28.8% identity (58.8% similar) in 320 aa overlap (76-382:35-333) 50 60 70 80 90 100 pF1KE3 PDQLTASLQPEPPAPARPSAGGPRARDVAQYLLSDSLFVWVLVNTACCVLMLVAKLIQCI :: ..: . :: : ...:..:.. . XP_011 AVMMAASLALTGAVVAHAYYLKHQFYPTVVYLTKSSPSMAVLYIQAFVLVFLLGKVMGKV 10 20 30 40 50 60 110 120 130 140 150 160 pF1KE3 VFGPLRVSERQHLKDKFWNFIFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLC :: ::..: .:: .. : . . . : :. . . : :. :.::. . : XP_011 FFGQLRAAEMEHLLERSW-YAVTETCLAFTVFRDDFSPRFVAL---FTLLLFLKCFHWLA 70 80 90 100 110 120 170 180 190 200 210 pF1KE3 KDRFEYLSFSPTTPMSSHGRVLSLLVAMLLSCCGLAAVCSITGYTHGMHT------LAFM .:: ... ::. : :..::. . :. .. :.. : :.: XP_011 EDRVDFMERSPNISWLFHCRIVSLMFLL-----GILDFLFVSHAYHSILTRGASVQLVFG 130 140 150 160 170 220 230 240 250 260 270 pF1KE3 AAESLLVTVRTAHVILRYVIHLWDLNHEGTWEGKGTYVYYTD----FVMELTLLS-LDLM ..:.:. . ....::.: ::. :. :..:..:. ::. :. : .. . .: XP_011 FEYAILMTM-VLTIFIKYVLHSVDLQSENPWDNKAVYMLYTELFTGFIKVLLYMAFMTIM 180 190 200 210 220 230 280 290 300 310 320 330 pF1KE3 HHIHML-LFGNIWLSMASLVIFMQLRYLFHEVQRRIRRHKNYLRVVGNMEARFAVATPEE ..: . :: : ... .: . . : : . :.. ::.. . ::::: XP_011 IKVHTFPLF-------AIRPMYLAMRQFKKAVTDAIMSR----RAIRNMNTLYPDATPEE 240 250 260 270 280 340 350 360 370 380 390 pF1KE3 LAVNNDDCAICWDSM-QAARKLPCGHLFHNSCLRSWLEQDTSCPTCRMSLNIADNNRVRE : . .. : :: . : .:..:::.:.::.::::::.... .::::::.. XP_011 LQAMDNVCIICREEMVTGAKRLPCNHIFHTSCLRSWFQRQQTCPTCRMDVLRASLPAQSP 290 300 310 320 330 340 400 410 420 430 440 450 pF1KE3 EHQGENLDENLVPVAAAEGRPRLNQHNHFFHFDGSRIASWLPSFSVEVMHTTNILGITQA XP_011 PPPEPADQGPPPAPHPPPLLPQPPNFPQGLLPPFPPGMFPLWPPMGPFPPVPPPPSSGEA 350 360 370 380 390 400 >>XP_016868491 (OMIM: 144700,603046) PREDICTED: E3 ubiqu (537 aa) initn: 208 init1: 143 opt: 216 Z-score: 188.3 bits: 44.8 E(85289): 0.00095 Smith-Waterman score: 221; 23.5% identity (53.0% similar) in 319 aa overlap (126-419:203-506) 100 110 120 130 140 150 pF1KE3 MLVAKLIQCIVFGPLRVSERQHLKDKFWNFIFYKFIFIFGVLNVQTVEEVVM----WCLW .:. . . :. ... :... :: XP_016 SVAHYLGLGILAFIGSTEEDDRRLGFVAPVLFFILALQTGLSGLRPEERLIRLSRNMCLL 180 190 200 210 220 230 160 170 180 190 200 210 pF1KE3 FAGLVFLHLMVQLCKDRFEYLSFSPTTPMSSHGRVLSLLVAMLLSCCGLAAVCSITGYTH .... ::.. . . :: : .. . : :: . . ... : .. : . . : XP_016 LTAV--LHFIHGMTDPVLMSLSASHVSSFRRHFPVLFVSACLFI----LPVLLSYVLWHH 240 250 260 270 280 220 230 240 250 260 pF1KE3 -GMHTLAF-MAAESLLVTVRTAHVILRYVIHLWDLNHEGTWEGKGTYVYY---TDFVMEL ...: : ..: . . ... . :.. . : .. :: :::: : ..:. XP_016 YALNTWLFAVTAFCVELCLKVIVSLTVYTLFMIDGYYNVLWEKLDDYVYYVRSTGSIIEF 290 300 310 320 330 340 270 280 290 300 310 320 pF1KE3 TLLSLDLMHHIHMLLFGNIWLSMASLVIFMQLRYLFHEVQRRIRRHKNYLRVVGNMEARF . . . . . ..: : ... ::. . . .. . :: .. :. : XP_016 IFGVVMFGNGAYTMMFE----SGSKIRAFMMCLHAYFNIYLQA---KNGWKTF--MNRRT 350 360 370 380 390 330 340 350 360 370 pF1KE3 AV----ATPE----ELAVNNDDCAICWDSMQ-AARKLPCGHLFHNSCLRSWLEQDTSCPT :: . :: .: :: ::::. . .:: ::.: :: :::.:: . .:: XP_016 AVKKINSLPEIKGSRLQEINDVCAICYHEFTTSARITPCNHYFHALCLRKWLYIQDTCPM 400 410 420 430 440 450 380 390 400 410 420 430 pF1KE3 CRMSL----NIADNNRVREEH---QGENLDENLVPVAAAEGRPRLNQHNHFFHFDGSRIA :.... .: ::. : ... .. :. : ::::. .::. . XP_016 CHQKVYIEDDIKDNSNVSNNNGFIPPNETPEEAVREAAAESDRELNEDDSTDCDDDVQRE 460 470 480 490 500 510 440 450 460 470 480 490 pF1KE3 SWLPSFSVEVMHTTNILGITQASNSQLNAMAHQIQEMFPQVPYHLVLQDLQLTRSVEITT XP_016 RNGVIQHTGAAAEEFNDDTD 520 530 >>NP_009149 (OMIM: 144700,603046) E3 ubiquitin-protein l (664 aa) initn: 208 init1: 143 opt: 216 Z-score: 187.2 bits: 44.9 E(85289): 0.0011 Smith-Waterman score: 221; 23.5% identity (53.0% similar) in 319 aa overlap (126-419:330-633) 100 110 120 130 140 150 pF1KE3 MLVAKLIQCIVFGPLRVSERQHLKDKFWNFIFYKFIFIFGVLNVQTVEEVVM----WCLW .:. . . :. ... :... :: NP_009 SVAHYLGLGILAFIGSTEEDDRRLGFVAPVLFFILALQTGLSGLRPEERLIRLSRNMCLL 300 310 320 330 340 350 160 170 180 190 200 210 pF1KE3 FAGLVFLHLMVQLCKDRFEYLSFSPTTPMSSHGRVLSLLVAMLLSCCGLAAVCSITGYTH .... ::.. . . :: : .. . : :: . . ... : .. : . . : NP_009 LTAV--LHFIHGMTDPVLMSLSASHVSSFRRHFPVLFVSACLFI----LPVLLSYVLWHH 360 370 380 390 400 410 220 230 240 250 260 pF1KE3 -GMHTLAF-MAAESLLVTVRTAHVILRYVIHLWDLNHEGTWEGKGTYVYY---TDFVMEL ...: : ..: . . ... . :.. . : .. :: :::: : ..:. NP_009 YALNTWLFAVTAFCVELCLKVIVSLTVYTLFMIDGYYNVLWEKLDDYVYYVRSTGSIIEF 420 430 440 450 460 470 270 280 290 300 310 320 pF1KE3 TLLSLDLMHHIHMLLFGNIWLSMASLVIFMQLRYLFHEVQRRIRRHKNYLRVVGNMEARF . . . . . ..: : ... ::. . . .. . :: .. :. : NP_009 IFGVVMFGNGAYTMMFE----SGSKIRAFMMCLHAYFNIYLQA---KNGWKTF--MNRRT 480 490 500 510 520 330 340 350 360 370 pF1KE3 AV----ATPE----ELAVNNDDCAICWDSMQ-AARKLPCGHLFHNSCLRSWLEQDTSCPT :: . :: .: :: ::::. . .:: ::.: :: :::.:: . .:: NP_009 AVKKINSLPEIKGSRLQEINDVCAICYHEFTTSARITPCNHYFHALCLRKWLYIQDTCPM 530 540 550 560 570 580 380 390 400 410 420 430 pF1KE3 CRMSL----NIADNNRVREEH---QGENLDENLVPVAAAEGRPRLNQHNHFFHFDGSRIA :.... .: ::. : ... .. :. : ::::. .::. . NP_009 CHQKVYIEDDIKDNSNVSNNNGFIPPNETPEEAVREAAAESDRELNEDDSTDCDDDVQRE 590 600 610 620 630 640 440 450 460 470 480 490 pF1KE3 SWLPSFSVEVMHTTNILGITQASNSQLNAMAHQIQEMFPQVPYHLVLQDLQLTRSVEITT NP_009 RNGVIQHTGAAAEEFNDDTD 650 660 >>XP_005259651 (OMIM: 615177) PREDICTED: E3 ubiquitin-pr (284 aa) initn: 193 init1: 170 opt: 198 Z-score: 177.0 bits: 41.8 E(85289): 0.004 Smith-Waterman score: 198; 41.7% identity (68.1% similar) in 72 aa overlap (322-387:183-254) 300 310 320 330 340 pF1KE3 LVIFMQLRYLFHEVQRRIRRHKNYLRVVGNMEARFAVATPEELAVNNDDCAICWDSM--- ..: .: . :: . .. .: .: :.. XP_005 AWGANGLDAIITQLLNQFENTGPPPADKEKIQALPTVPVTEEHVGSGLECPVCKDDYALG 160 170 180 190 200 210 350 360 370 380 390 400 pF1KE3 QAARKLPCGHLFHNSCLRSWLEQDTSCPTCRMSL---NIADNNRVREEHQGENLDENLVP . .:.:::.::::..:. :::: :::.:: :: : : : XP_005 ERVRQLPCNHLFHDGCIVPWLEQHDSCPVCRKSLTGQNTATNPPGLTGVSFSSSSSSSSS 220 230 240 250 260 270 410 420 430 440 450 460 pF1KE3 VAAAEGRPRLNQHNHFFHFDGSRIASWLPSFSVEVMHTTNILGITQASNSQLNAMAHQIQ XP_005 SSPSNENATSNS 280 643 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 01:38:14 2016 done: Sun Nov 6 01:38:16 2016 Total Scan time: 12.230 Total Display time: 0.100 Function used was FASTA [36.3.4 Apr, 2011]