FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2482, 468 aa 1>>>pF1KE2482 468 - 468 aa - 468 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.7485+/-0.000395; mu= 11.5014+/- 0.025 mean_var=109.4188+/-22.420, 0's: 0 Z-trim(115.1): 409 B-trim: 19 in 1/49 Lambda= 0.122611 statistics sampled from 25005 (25417) to 25005 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.664), E-opt: 0.2 (0.298), width: 16 Scan time: 8.090 The best scores are: opt bits E(85289) NP_599024 (OMIM: 600825) nuclear receptor ROR-alph ( 468) 3180 573.5 4.4e-163 NP_002934 (OMIM: 600825) nuclear receptor ROR-alph ( 548) 3129 564.5 2.6e-160 XP_016877955 (OMIM: 600825) PREDICTED: nuclear rec ( 460) 3124 563.5 4.2e-160 NP_599022 (OMIM: 600825) nuclear receptor ROR-alph ( 556) 3124 563.6 4.9e-160 XP_011520176 (OMIM: 600825) PREDICTED: nuclear rec ( 525) 3120 562.9 7.6e-160 XP_011520179 (OMIM: 600825) PREDICTED: nuclear rec ( 467) 3119 562.7 7.8e-160 XP_005254641 (OMIM: 600825) PREDICTED: nuclear rec ( 477) 3113 561.6 1.7e-159 XP_011520177 (OMIM: 600825) PREDICTED: nuclear rec ( 504) 3113 561.6 1.7e-159 NP_599023 (OMIM: 600825) nuclear receptor ROR-alph ( 523) 3113 561.6 1.8e-159 XP_016877956 (OMIM: 600825) PREDICTED: nuclear rec ( 386) 2590 469.0 9.8e-132 XP_011520180 (OMIM: 600825) PREDICTED: nuclear rec ( 386) 2590 469.0 9.8e-132 XP_011520181 (OMIM: 600825) PREDICTED: nuclear rec ( 376) 2524 457.4 3.1e-128 NP_008845 (OMIM: 601972) nuclear receptor ROR-beta ( 459) 1971 359.6 1e-98 NP_001001523 (OMIM: 602943,616622) nuclear recepto ( 497) 950 179.0 2.6e-44 NP_005051 (OMIM: 602943,616622) nuclear receptor R ( 518) 950 179.0 2.7e-44 XP_006711547 (OMIM: 602943,616622) PREDICTED: nucl ( 651) 950 179.1 3.2e-44 NP_068370 (OMIM: 602408) nuclear receptor subfamil ( 614) 438 88.5 5.6e-17 XP_006713514 (OMIM: 602304) PREDICTED: nuclear rec ( 448) 428 86.6 1.5e-16 NP_001138897 (OMIM: 602304) nuclear receptor subfa ( 504) 428 86.7 1.6e-16 NP_005117 (OMIM: 602304) nuclear receptor subfamil ( 579) 428 86.7 1.8e-16 XP_005251928 (OMIM: 184757,612964,612965,613957) P ( 461) 419 85.1 4.6e-16 NP_004950 (OMIM: 184757,612964,612965,613957) ster ( 461) 419 85.1 4.6e-16 XP_011516757 (OMIM: 184757,612964,612965,613957) P ( 461) 419 85.1 4.6e-16 NP_001277195 (OMIM: 180220,615524) retinoic acid r ( 399) 417 84.7 5.2e-16 NP_001277206 (OMIM: 180220,615524) retinoic acid r ( 402) 417 84.7 5.2e-16 NP_001277229 (OMIM: 180220,615524) retinoic acid r ( 405) 417 84.7 5.2e-16 NP_000956 (OMIM: 180220,615524) retinoic acid rece ( 448) 417 84.7 5.7e-16 NP_001277145 (OMIM: 180220,615524) retinoic acid r ( 455) 417 84.7 5.8e-16 NP_001230659 (OMIM: 180190) retinoic acid receptor ( 382) 415 84.3 6.4e-16 NP_001036193 (OMIM: 180190) retinoic acid receptor ( 443) 415 84.3 7.2e-16 NP_000957 (OMIM: 180190) retinoic acid receptor ga ( 454) 415 84.3 7.4e-16 XP_011523398 (OMIM: 180240,612376) PREDICTED: reti ( 404) 407 82.9 1.8e-15 NP_001019980 (OMIM: 180240,612376) retinoic acid r ( 457) 407 82.9 2e-15 XP_005257610 (OMIM: 180240,612376) PREDICTED: reti ( 462) 407 82.9 2e-15 NP_000955 (OMIM: 180240,612376) retinoic acid rece ( 462) 407 82.9 2e-15 XP_011523397 (OMIM: 180240,612376) PREDICTED: reti ( 462) 407 82.9 2e-15 NP_001138773 (OMIM: 180240,612376) retinoic acid r ( 462) 407 82.9 2e-15 XP_005257611 (OMIM: 180240,612376) PREDICTED: reti ( 462) 407 82.9 2e-15 XP_005257609 (OMIM: 180240,612376) PREDICTED: reti ( 478) 407 82.9 2e-15 NP_001027458 (OMIM: 601529) nuclear receptor subfa ( 467) 399 81.5 5.4e-15 NP_001120834 (OMIM: 601529) nuclear receptor subfa ( 483) 399 81.5 5.5e-15 NP_001278850 (OMIM: 180245) retinoic acid receptor ( 365) 397 81.1 5.6e-15 XP_011537019 (OMIM: 601529) PREDICTED: nuclear rec ( 507) 399 81.5 5.7e-15 XP_011537018 (OMIM: 601529) PREDICTED: nuclear rec ( 521) 399 81.6 5.9e-15 XP_006719647 (OMIM: 601529) PREDICTED: nuclear rec ( 557) 399 81.6 6.2e-15 NP_001278849 (OMIM: 180245) retinoic acid receptor ( 435) 397 81.2 6.5e-15 XP_005269190 (OMIM: 601529) PREDICTED: nuclear rec ( 598) 399 81.6 6.6e-15 NP_003288 (OMIM: 601529) nuclear receptor subfamil ( 603) 399 81.6 6.6e-15 NP_002948 (OMIM: 180245) retinoic acid receptor RX ( 462) 397 81.2 6.8e-15 XP_011532146 (OMIM: 125853,601487,601665,604367,60 ( 250) 389 79.6 1.1e-14 >>NP_599024 (OMIM: 600825) nuclear receptor ROR-alpha is (468 aa) initn: 3180 init1: 3180 opt: 3180 Z-score: 3048.8 bits: 573.5 E(85289): 4.4e-163 Smith-Waterman score: 3180; 100.0% identity (100.0% similar) in 468 aa overlap (1-468:1-468) 10 20 30 40 50 60 pF1KE2 MMYFVIAAMKAQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_599 MMYFVIAAMKAQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 LIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_599 LIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 PGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_599 PGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 INGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_599 INGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREEL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 QQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_599 QQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 LKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_599 LKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 TEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_599 TEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVS 370 380 390 400 410 420 430 440 450 460 pF1KE2 TLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG :::::::::::::::::::::::::::::::::::::::::::::::: NP_599 TLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG 430 440 450 460 >>NP_002934 (OMIM: 600825) nuclear receptor ROR-alpha is (548 aa) initn: 3127 init1: 3127 opt: 3129 Z-score: 2999.1 bits: 564.5 E(85289): 2.6e-160 Smith-Waterman score: 3129; 98.9% identity (99.6% similar) in 466 aa overlap (4-468:83-548) 10 20 30 pF1KE2 MMYFVIAAM-KAQIEIIPCKICGDKSSGIHYGV :.. :. ::::::::::::::::::::::: NP_002 LSRLFWSQLEHINWDGATAKNFINLREFFSFLLPALRKAQIEIIPCKICGDKSSGIHYGV 60 70 80 90 100 110 40 50 60 70 80 90 pF1KE2 ITCEGCKGFFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 ITCEGCKGFFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGR 120 130 140 150 160 170 100 110 120 130 140 150 pF1KE2 MSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGH 180 190 200 210 220 230 160 170 180 190 200 210 pF1KE2 TPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 TPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPT 240 250 260 270 280 290 220 230 240 250 260 270 pF1KE2 VSMAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 VSMAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKI 300 310 320 330 340 350 280 290 300 310 320 330 pF1KE2 TEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 TEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYAS 360 370 380 390 400 410 340 350 360 370 380 390 pF1KE2 PDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 PDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQ 420 430 440 450 460 470 400 410 420 430 440 450 pF1KE2 KIQLALQHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 KIQLALQHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLY 480 490 500 510 520 530 460 pF1KE2 KELFTSEFEPAMQIDG :::::::::::::::: NP_002 KELFTSEFEPAMQIDG 540 >>XP_016877955 (OMIM: 600825) PREDICTED: nuclear recepto (460 aa) initn: 3124 init1: 3124 opt: 3124 Z-score: 2995.4 bits: 563.5 E(85289): 4.2e-160 Smith-Waterman score: 3124; 99.8% identity (100.0% similar) in 460 aa overlap (9-468:1-460) 10 20 30 40 50 60 pF1KE2 MMYFVIAAMKAQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNC :.:::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MNAQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNC 10 20 30 40 50 70 80 90 100 110 120 pF1KE2 LIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQ 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE2 PGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLD 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE2 INGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 INGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREEL 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE2 QQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVL 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE2 LKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHL 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE2 TEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVS 360 370 380 390 400 410 430 440 450 460 pF1KE2 TLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG :::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG 420 430 440 450 460 >>NP_599022 (OMIM: 600825) nuclear receptor ROR-alpha is (556 aa) initn: 3124 init1: 3124 opt: 3124 Z-score: 2994.2 bits: 563.6 E(85289): 4.9e-160 Smith-Waterman score: 3124; 99.8% identity (100.0% similar) in 460 aa overlap (9-468:97-556) 10 20 30 pF1KE2 MMYFVIAAMKAQIEIIPCKICGDKSSGIHYGVITCEGC :.:::::::::::::::::::::::::::: NP_599 FVLTGVCCSWRQNGKPPYSQKEDKEVQTGYMNAQIEIIPCKICGDKSSGIHYGVITCEGC 70 80 90 100 110 120 40 50 60 70 80 90 pF1KE2 KGFFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_599 KGFFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQR 130 140 150 160 170 180 100 110 120 130 140 150 pF1KE2 DSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_599 DSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSK 190 200 210 220 230 240 160 170 180 190 200 210 pF1KE2 ADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_599 ADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAEL 250 260 270 280 290 300 220 230 240 250 260 270 pF1KE2 EHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_599 EHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQY 310 320 330 340 350 360 280 290 300 310 320 330 pF1KE2 VVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_599 VVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKS 370 380 390 400 410 420 340 350 360 370 380 390 pF1KE2 LGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_599 LGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLAL 430 440 450 460 470 480 400 410 420 430 440 450 pF1KE2 QHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_599 QHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTS 490 500 510 520 530 540 460 pF1KE2 EFEPAMQIDG :::::::::: NP_599 EFEPAMQIDG 550 >>XP_011520176 (OMIM: 600825) PREDICTED: nuclear recepto (525 aa) initn: 3120 init1: 3120 opt: 3120 Z-score: 2990.7 bits: 562.9 E(85289): 7.6e-160 Smith-Waterman score: 3120; 99.6% identity (99.6% similar) in 461 aa overlap (8-468:65-525) 10 20 30 pF1KE2 MMYFVIAAMKAQIEIIPCKICGDKSSGIHYGVITCEG : ::::::::::::::::::::::::::: XP_011 VGLRASCPTEWGQKVVRGAFRGALRAEKRPAATAQIEIIPCKICGDKSSGIHYGVITCEG 40 50 60 70 80 90 40 50 60 70 80 90 pF1KE2 CKGFFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CKGFFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQ 100 110 120 130 140 150 100 110 120 130 140 150 pF1KE2 RDSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RDSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGS 160 170 180 190 200 210 160 170 180 190 200 210 pF1KE2 KADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAE 220 230 240 250 260 270 220 230 240 250 260 270 pF1KE2 LEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQ 280 290 300 310 320 330 280 290 300 310 320 330 pF1KE2 YVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFK 340 350 360 370 380 390 340 350 360 370 380 390 pF1KE2 SLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLA 400 410 420 430 440 450 400 410 420 430 440 450 pF1KE2 LQHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LQHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFT 460 470 480 490 500 510 460 pF1KE2 SEFEPAMQIDG ::::::::::: XP_011 SEFEPAMQIDG 520 >>XP_011520179 (OMIM: 600825) PREDICTED: nuclear recepto (467 aa) initn: 3117 init1: 3117 opt: 3119 Z-score: 2990.5 bits: 562.7 E(85289): 7.8e-160 Smith-Waterman score: 3119; 98.5% identity (98.9% similar) in 467 aa overlap (2-468:1-467) 10 20 30 40 50 60 pF1KE2 MMYFVIAAMKAQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNC : : .. :::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MKFREGTAIAQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNC 10 20 30 40 50 70 80 90 100 110 120 pF1KE2 LIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQ 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE2 PGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLD 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE2 INGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 INGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREEL 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE2 QQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVL 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE2 LKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHL 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE2 TEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVS 360 370 380 390 400 410 430 440 450 460 pF1KE2 TLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG :::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG 420 430 440 450 460 >>XP_005254641 (OMIM: 600825) PREDICTED: nuclear recepto (477 aa) initn: 3113 init1: 3113 opt: 3113 Z-score: 2984.7 bits: 561.6 E(85289): 1.7e-159 Smith-Waterman score: 3113; 99.8% identity (100.0% similar) in 458 aa overlap (11-468:20-477) 10 20 30 40 50 pF1KE2 MMYFVIAAMKAQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNAT .:::::::::::::::::::::::::::::::::::::::: XP_005 MLTGSQSTFGISVTKKTHTSQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNAT 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 YSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQ 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 QQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQ 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE2 PSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLE 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE2 TCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFME 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE2 LCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEF 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE2 GKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGI 370 380 390 400 410 420 420 430 440 450 460 pF1KE2 LTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG 430 440 450 460 470 >>XP_011520177 (OMIM: 600825) PREDICTED: nuclear recepto (504 aa) initn: 3113 init1: 3113 opt: 3113 Z-score: 2984.3 bits: 561.6 E(85289): 1.7e-159 Smith-Waterman score: 3113; 99.8% identity (100.0% similar) in 458 aa overlap (11-468:47-504) 10 20 30 40 pF1KE2 MMYFVIAAMKAQIEIIPCKICGDKSSGIHYGVITCEGCKG .::::::::::::::::::::::::::::: XP_011 TEAIRTTHAVLLKKPPGWKSGISVTKKTHTSQIEIIPCKICGDKSSGIHYGVITCEGCKG 20 30 40 50 60 70 50 60 70 80 90 100 pF1KE2 FFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDS 80 90 100 110 120 130 110 120 130 140 150 160 pF1KE2 LYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKAD 140 150 160 170 180 190 170 180 190 200 210 220 pF1KE2 SAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEH 200 210 220 230 240 250 230 240 250 260 270 280 pF1KE2 LAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVV 260 270 280 290 300 310 290 300 310 320 330 340 pF1KE2 EFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLG 320 330 340 350 360 370 350 360 370 380 390 400 pF1KE2 CEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQH 380 390 400 410 420 430 410 420 430 440 450 460 pF1KE2 VLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEF 440 450 460 470 480 490 pF1KE2 EPAMQIDG :::::::: XP_011 EPAMQIDG 500 >>NP_599023 (OMIM: 600825) nuclear receptor ROR-alpha is (523 aa) initn: 3113 init1: 3113 opt: 3113 Z-score: 2984.1 bits: 561.6 E(85289): 1.8e-159 Smith-Waterman score: 3113; 99.8% identity (100.0% similar) in 458 aa overlap (11-468:66-523) 10 20 30 40 pF1KE2 MMYFVIAAMKAQIEIIPCKICGDKSSGIHYGVITCEGCKG .::::::::::::::::::::::::::::: NP_599 ARKSEPPAPVRRQSYSSTSRGISVTKKTHTSQIEIIPCKICGDKSSGIHYGVITCEGCKG 40 50 60 70 80 90 50 60 70 80 90 100 pF1KE2 FFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_599 FFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDS 100 110 120 130 140 150 110 120 130 140 150 160 pF1KE2 LYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_599 LYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKAD 160 170 180 190 200 210 170 180 190 200 210 220 pF1KE2 SAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_599 SAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEH 220 230 240 250 260 270 230 240 250 260 270 280 pF1KE2 LAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_599 LAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVV 280 290 300 310 320 330 290 300 310 320 330 340 pF1KE2 EFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_599 EFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLG 340 350 360 370 380 390 350 360 370 380 390 400 pF1KE2 CEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_599 CEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQH 400 410 420 430 440 450 410 420 430 440 450 460 pF1KE2 VLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_599 VLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEF 460 470 480 490 500 510 pF1KE2 EPAMQIDG :::::::: NP_599 EPAMQIDG 520 >>XP_016877956 (OMIM: 600825) PREDICTED: nuclear recepto (386 aa) initn: 2590 init1: 2590 opt: 2590 Z-score: 2486.0 bits: 469.0 E(85289): 9.8e-132 Smith-Waterman score: 2590; 100.0% identity (100.0% similar) in 386 aa overlap (83-468:1-386) 60 70 80 90 100 110 pF1KE2 SCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQ :::::::::::::::::::::::::::::: XP_016 MSRDAVKFGRMSKKQRDSLYAEVQKHRMQQ 10 20 30 120 130 140 150 160 170 pF1KE2 QQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQP 40 50 60 70 80 90 180 190 200 210 220 230 pF1KE2 SPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLET 100 110 120 130 140 150 240 250 260 270 280 290 pF1KE2 CQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMEL 160 170 180 190 200 210 300 310 320 330 340 350 pF1KE2 CQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFG 220 230 240 250 260 270 360 370 380 390 400 410 pF1KE2 KSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGIL 280 290 300 310 320 330 420 430 440 450 460 pF1KE2 TKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG 340 350 360 370 380 468 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 20:45:25 2016 done: Mon Nov 7 20:45:26 2016 Total Scan time: 8.090 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]