FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1886, 412 aa 1>>>pF1KE1886 412 - 412 aa - 412 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0977+/-0.000366; mu= 18.2805+/- 0.023 mean_var=64.4847+/-12.845, 0's: 0 Z-trim(114.1): 81 B-trim: 465 in 1/48 Lambda= 0.159715 statistics sampled from 23616 (23703) to 23616 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.659), E-opt: 0.2 (0.278), width: 16 Scan time: 8.590 The best scores are: opt bits E(85289) NP_001316868 (OMIM: 107970,190230,615582) transfor ( 412) 2828 660.4 2.3e-189 NP_003230 (OMIM: 107970,190230,615582) transformin ( 412) 2828 660.4 2.3e-189 NP_001316867 (OMIM: 107970,190230,615582) transfor ( 309) 2081 488.2 1.2e-137 NP_003229 (OMIM: 190220,614816) transforming growt ( 414) 1559 368.0 2.4e-101 NP_001129071 (OMIM: 190220,614816) transforming gr ( 442) 1232 292.7 1.2e-78 NP_000651 (OMIM: 131300,190180,219700) transformin ( 390) 700 170.0 8.9e-42 XP_011525544 (OMIM: 131300,190180,219700) PREDICTE ( 391) 700 170.0 8.9e-42 NP_001710 (OMIM: 112267) bone morphogenetic protei ( 431) 374 95.0 3.9e-19 XP_016867665 (OMIM: 147290) PREDICTED: inhibin bet ( 426) 317 81.8 3.5e-15 NP_002183 (OMIM: 147290) inhibin beta A chain prep ( 426) 317 81.8 3.5e-15 XP_016867664 (OMIM: 147290) PREDICTED: inhibin bet ( 483) 317 81.9 3.9e-15 XP_016867663 (OMIM: 147290) PREDICTED: inhibin bet ( 548) 317 81.9 4.3e-15 NP_113667 (OMIM: 612031) inhibin beta E chain prep ( 350) 303 78.5 2.8e-14 XP_006719257 (OMIM: 603936) PREDICTED: growth/diff ( 407) 298 77.4 7e-14 NP_005802 (OMIM: 603936) growth/differentiation fa ( 407) 298 77.4 7e-14 NP_005250 (OMIM: 601788,614160) growth/differentia ( 375) 297 77.2 7.7e-14 NP_001709 (OMIM: 112266) bone morphogenetic protei ( 513) 289 75.4 3.6e-13 NP_001001557 (OMIM: 118100,601147,613094,613703,61 ( 455) 276 72.4 2.6e-12 XP_011527377 (OMIM: 112600,113100,200700,201250,22 ( 501) 275 72.2 3.3e-12 NP_000548 (OMIM: 112600,113100,200700,201250,22890 ( 501) 275 72.2 3.3e-12 NP_001306067 (OMIM: 112600,113100,200700,201250,22 ( 501) 275 72.2 3.3e-12 XP_011527625 (OMIM: 112261,112600,235200) PREDICTE ( 240) 266 69.9 7.6e-12 NP_001191 (OMIM: 112261,112600,235200) bone morpho ( 396) 266 70.0 1.1e-11 NP_002184 (OMIM: 147390) inhibin beta B chain prep ( 407) 264 69.6 1.6e-11 NP_005529 (OMIM: 601233) inhibin beta C chain prep ( 352) 260 68.6 2.7e-11 XP_016866687 (OMIM: 112265) PREDICTED: bone morpho ( 239) 258 68.1 2.7e-11 NP_878248 (OMIM: 604651) growth/differentiation fa ( 450) 259 68.5 3.9e-11 NP_066551 (OMIM: 112265) bone morphogenetic protei ( 454) 258 68.2 4.6e-11 NP_055297 (OMIM: 608748) bone morphogenetic protei ( 424) 247 65.7 2.5e-10 NP_001483 (OMIM: 187500,208530,217095,602880,61385 ( 372) 243 64.7 4.3e-10 NP_065685 (OMIM: 606522,613702,613703,613704) grow ( 364) 242 64.5 4.9e-10 XP_016877094 (OMIM: 112262,600625,607932) PREDICTE ( 345) 239 63.8 7.6e-10 XP_016877093 (OMIM: 112262,600625,607932) PREDICTE ( 345) 239 63.8 7.6e-10 XP_016877092 (OMIM: 112262,600625,607932) PREDICTE ( 408) 239 63.8 8.7e-10 XP_005268072 (OMIM: 112262,600625,607932) PREDICTE ( 408) 239 63.8 8.7e-10 NP_570911 (OMIM: 112262,600625,607932) bone morpho ( 408) 239 63.8 8.7e-10 NP_001193 (OMIM: 112262,600625,607932) bone morpho ( 408) 239 63.8 8.7e-10 NP_001711 (OMIM: 602284) bone morphogenetic protei ( 402) 228 61.3 5e-09 NP_004855 (OMIM: 605312) growth/differentiation fa ( 308) 223 60.1 8.9e-09 NP_001192 (OMIM: 112263) bone morphogenetic protei ( 472) 223 60.2 1.3e-08 NP_001316835 (OMIM: 270100,601265) nodal homolog i ( 214) 190 52.4 1.3e-06 NP_060525 (OMIM: 270100,601265) nodal homolog isof ( 347) 190 52.5 1.9e-06 NP_004953 (OMIM: 601361) growth/differentiation fa ( 478) 189 52.4 2.9e-06 NP_057288 (OMIM: 605120,615506) growth/differentia ( 429) 187 51.9 3.7e-06 NP_003231 (OMIM: 601877) left-right determination ( 366) 175 49.1 2.2e-05 NP_066277 (OMIM: 603037) left-right determination ( 366) 170 47.9 4.9e-05 NP_001165896 (OMIM: 601877) left-right determinati ( 332) 163 46.3 0.00014 XP_011541613 (OMIM: 601918) PREDICTED: growth/diff ( 276) 153 43.9 0.00058 XP_005272014 (OMIM: 601918) PREDICTED: growth/diff ( 366) 153 44.0 0.00074 XP_011541611 (OMIM: 601918) PREDICTED: growth/diff ( 366) 153 44.0 0.00074 >>NP_001316868 (OMIM: 107970,190230,615582) transforming (412 aa) initn: 2828 init1: 2828 opt: 2828 Z-score: 3520.7 bits: 660.4 E(85289): 2.3e-189 Smith-Waterman score: 2828; 100.0% identity (100.0% similar) in 412 aa overlap (1-412:1-412) 10 20 30 40 50 60 pF1KE1 MKMHLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MKMHLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEPT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 VMTHVPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQGLAEHNEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VMTHVPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQGLAEHNEL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 AVCPKGITSKVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQRIELFQILRPDEHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVCPKGITSKVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQRIELFQILRPDEHI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 AKQRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQPNGDILE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AKQRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQPNGDILE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 NIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 ALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHST 310 320 330 340 350 360 370 380 390 400 410 pF1KE1 VLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS 370 380 390 400 410 >>NP_003230 (OMIM: 107970,190230,615582) transforming gr (412 aa) initn: 2828 init1: 2828 opt: 2828 Z-score: 3520.7 bits: 660.4 E(85289): 2.3e-189 Smith-Waterman score: 2828; 100.0% identity (100.0% similar) in 412 aa overlap (1-412:1-412) 10 20 30 40 50 60 pF1KE1 MKMHLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MKMHLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEPT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 VMTHVPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQGLAEHNEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 VMTHVPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQGLAEHNEL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 AVCPKGITSKVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQRIELFQILRPDEHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 AVCPKGITSKVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQRIELFQILRPDEHI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 AKQRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQPNGDILE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 AKQRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQPNGDILE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 NIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 NIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 ALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 ALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHST 310 320 330 340 350 360 370 380 390 400 410 pF1KE1 VLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 VLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS 370 380 390 400 410 >>NP_001316867 (OMIM: 107970,190230,615582) transforming (309 aa) initn: 2081 init1: 2081 opt: 2081 Z-score: 2592.3 bits: 488.2 E(85289): 1.2e-137 Smith-Waterman score: 2081; 100.0% identity (100.0% similar) in 309 aa overlap (1-309:1-309) 10 20 30 40 50 60 pF1KE1 MKMHLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MKMHLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEPT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 VMTHVPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQGLAEHNEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VMTHVPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQGLAEHNEL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 AVCPKGITSKVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQRIELFQILRPDEHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVCPKGITSKVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQRIELFQILRPDEHI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 AKQRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQPNGDILE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AKQRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQPNGDILE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 NIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 ALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHST ::::::::: NP_001 ALDTNYCFR >>NP_003229 (OMIM: 190220,614816) transforming growth fa (414 aa) initn: 1532 init1: 725 opt: 1559 Z-score: 1940.4 bits: 368.0 E(85289): 2.4e-101 Smith-Waterman score: 1559; 55.7% identity (79.2% similar) in 418 aa overlap (3-412:1-414) 10 20 30 40 50 60 pF1KE1 MKMHLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEPT :: .: .. .:...::.::::::.:::. .. .::.:::::::::::.:::::: NP_003 MHYC-VLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDY 10 20 30 40 50 70 80 90 100 110 pF1KE1 VMTH-VPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQGLAEHNE . :: .:...:::::.::.: ..: .: .: .. ::::::..:.:: . .: NP_003 PEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSEN- 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 LAVCPKGITS--KVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQRIELFQILRP- :. : .. ::.::..::: .:: .:::::.:. ::... ::::::.:::. NP_003 -AIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSK 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 DEHIAKQRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQP-N : :::: .: . ::. .:::::::::.:.::: ... :::..::.:::: :: : : NP_003 DLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSN 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE1 GDILENIHEVMEIKFKGVDNEDDHGRGDLGRLK---KQKDHHNPHLILMMIPPHRLDNPG . :. : : .: .: :.:. . . :: .: :... ..:::.::..: .::.. NP_003 NYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQ- 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE1 QGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLR : ..:::::::. :::::...:::.:::::::..::::::.:::::: ::::.: :::: NP_003 QTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLW 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE1 SADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS :.:: :: ::.::::.::::::::::: :::::::::::.:.:::.::::::.::::::: NP_003 SSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS 360 370 380 390 400 410 >>NP_001129071 (OMIM: 190220,614816) transforming growth (442 aa) initn: 1535 init1: 725 opt: 1232 Z-score: 1532.8 bits: 292.7 E(85289): 1.2e-78 Smith-Waterman score: 1516; 52.7% identity (75.2% similar) in 444 aa overlap (3-412:1-442) 10 20 30 40 50 60 pF1KE1 MKMHLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEPT :: .: .. .:...::.::::::.:::. .. .::.:::::::::::.:::::: NP_001 MHYC-VLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDY 10 20 30 40 50 70 80 90 100 110 pF1KE1 VMTH-VPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDM--------- . :: .:...:::::.::.: ..: .: .: .. ::::::..:.:: NP_001 PEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSETV 60 70 80 90 100 110 120 130 140 150 pF1KE1 ----------IQGLAEHNELAVC------PKGITSKVFR---FNVSSVEKNRTNLFRAEF . .: .. ..: : . :: :.::..::: .:: .::: NP_001 CPVVTTPSGSVGSLCSRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEF 120 130 140 150 160 170 160 170 180 190 200 210 pF1KE1 RVLRVPNPSSKRNEQRIELFQILRP-DEHIAKQRYIGGKNLPTRGTAEWLSFDVTDTVRE ::.:. ::... ::::::.:::. : :::: .: . ::. .:::::::::.:.: NP_001 RVFRLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHE 180 190 200 210 220 230 220 230 240 250 260 pF1KE1 WLLRRESNLGLEISIHCPCHTFQP-NGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLK- :: ... :::..::.:::: :: : :. :. : : .: .: :.:. . . :: .: NP_001 WLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKS 240 250 260 270 280 290 270 280 290 300 310 320 pF1KE1 --KQKDHHNPHLILMMIPPHRLDNPGQGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQ :... ..:::.::..: .::.. : ..:::::::. :::::...:::.:::::::.. NP_001 TRKKNSGKTPHLLLMLLPSYRLESQ-QTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKR 300 310 320 330 340 350 330 340 350 360 370 380 pF1KE1 DLGWKWVHEPKGYYANFCSGPCPYLRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPL ::::::.:::::: ::::.: :::: :.:: :: ::.::::.::::::::::: :::::: NP_001 DLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPL 360 370 380 390 400 410 390 400 410 pF1KE1 TILYYVGRTPKVEQLSNMVVKSCKCS :::::.:.:::.::::::.::::::: NP_001 TILYYIGKTPKIEQLSNMIVKSCKCS 420 430 440 >>NP_000651 (OMIM: 131300,190180,219700) transforming gr (390 aa) initn: 1022 init1: 669 opt: 700 Z-score: 871.1 bits: 170.0 E(85289): 8.9e-42 Smith-Waterman score: 1093; 46.3% identity (67.3% similar) in 410 aa overlap (9-412:15-390) 10 20 30 40 50 pF1KE1 MKMHLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLT :. : .:. . . .:::: :.:. .:.::.:::::::::::::. NP_000 MPPSGLRLLPLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLA 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE1 SPPEPTVMTH--VPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQ ::: . .: :::::::::. .. :: : . . :..:::::. . :.. NP_000 SPPSQGEVPPGPLPEAVLALYNSTRD---RVAGESAE--PEPEPEADYYAKEVTRVLMVE 70 80 90 100 110 120 130 140 150 160 pF1KE1 GLAEHNELAVCPKGITSKVFRF-NVSSVEKNRTN---LFRAEFRVLRVPNPSSKRNEQRI :::. : : ... : :.: ... . : :::.:.::. . . ::.. NP_000 ---THNEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRL----KLKVEQHV 120 130 140 150 160 170 180 190 200 210 220 pF1KE1 ELFQILRPDEHIAKQRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCP ::.: . . ::.... : . :::::::: .::.:: : :...: :: NP_000 ELYQKYSNN----SWRYLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCS 170 180 190 200 210 220 230 240 250 260 270 280 pF1KE1 CHTFQPNGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRL : : .: .... ..: . ::::. .. . : :.:: : .: NP_000 C-------DSRDN---TLQVDINGFTTGR---RGDLATIH---GMNRPFLLLMATPLERA 230 240 250 260 290 300 310 320 330 340 pF1KE1 DNPGQGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPC .. ..:..::::::::: . :.::::: ::::::.::::::.::::::.:::: ::: NP_000 QH--LQSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPC 270 280 290 300 310 320 350 360 370 380 390 400 pF1KE1 PYLRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKS ::. : :: .: ::.::: :: :::.:::::: :::: :.::::: :::::::::.:.: NP_000 PYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRS 330 340 350 360 370 380 410 pF1KE1 CKCS :::: NP_000 CKCS 390 >>XP_011525544 (OMIM: 131300,190180,219700) PREDICTED: t (391 aa) initn: 1022 init1: 669 opt: 700 Z-score: 871.0 bits: 170.0 E(85289): 8.9e-42 Smith-Waterman score: 1087; 46.3% identity (65.6% similar) in 410 aa overlap (9-412:15-391) 10 20 30 40 50 pF1KE1 MKMHLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLT :. : .:. . . .:::: :.:. .:.::.:::::::::::::. XP_011 MPPSGLRLLPLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLA 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE1 SPPEPTVMTH--VPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQ ::: . .: :::::::::. .. :: : . . :..:::::. . :.. XP_011 SPPSQGEVPPGPLPEAVLALYNSTRD---RVAGESAE--PEPEPEADYYAKEVTRVLMVE 70 80 90 100 110 120 130 140 150 160 pF1KE1 GLAEHNELAVCPKGITSKVFRF-NVSSVEKNRTN---LFRAEFRVLRVPNPSSKRNEQRI :::. : : ... : :.: ... . : :::.:.::. . . ::.. XP_011 ---THNEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRL----KLKVEQHV 120 130 140 150 160 170 180 190 200 210 220 pF1KE1 ELFQILRPDEHIAKQRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCP ::.: . . ::.... : . :::::::: .::.:: : :...: :: XP_011 ELYQKYSNN----SWRYLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCS 170 180 190 200 210 220 230 240 250 260 270 280 pF1KE1 CHTFQPNGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRL : : .: .: : . : : : . . : :.:: : .: XP_011 C-------DSRDNTLQV--------DINAGFTTGRRGDLATIHGMNRPFLLLMATPLERA 230 240 250 260 290 300 310 320 330 340 pF1KE1 DNPGQGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPC .. ..:..::::::::: . :.::::: ::::::.::::::.::::::.:::: ::: XP_011 QH--LQSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPC 270 280 290 300 310 320 350 360 370 380 390 400 pF1KE1 PYLRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKS ::. : :: .: ::.::: :: :::.:::::: :::: :.::::: :::::::::.:.: XP_011 PYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRS 330 340 350 360 370 380 410 pF1KE1 CKCS :::: XP_011 CKCS 390 >>NP_001710 (OMIM: 112267) bone morphogenetic protein 7 (431 aa) initn: 308 init1: 115 opt: 374 Z-score: 464.5 bits: 95.0 E(85289): 3.9e-19 Smith-Waterman score: 408; 26.6% identity (56.1% similar) in 433 aa overlap (12-411:21-430) 10 20 30 40 pF1KE1 MKMHLQRALVVLALLNFATVSLSLSTCTTLDFGH--IKKKRVEAIRGQILS : :: : ...::.. . .: : ..... . .. .::: NP_001 MHVRSLRAAAPHSFVALWAPLFLLRSALADFSLDNEVHSSFIHRRLRSQERREMQREILS 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE1 KLRLTSPPEPTVM-TH--VPYQVLALYNSTRELLEEMHGEREEGCTQE-----NTESEYY : : :.: .. : .:. .: :::. .:: : .: . .:.. NP_001 ILGLPHRPRPHLQGKHNSAPMFMLDLYNAMA--VEEGGGPGGQGFSYPYKAVFSTQGPPL 70 80 90 100 110 110 120 130 140 150 pF1KE1 A--KEIHKF---DMIQG---LAEHNELAVCPKGITSKVFRFNVSSVEKNRTNLFRAEFRV : .. : . ::... :.::.. :. . :::..:.. .... . ::::. NP_001 ASLQDSHFLTDADMVMSFVNLVEHDKEFFHPR-YHHREFRFDLSKIPEGEA-VTAAEFRI 120 130 140 150 160 170 160 170 180 190 200 210 pF1KE1 LRVPNPSSKRNEQ-RIELFQILRPDEHIAKQRYIGGKNLPTRGTAE--WLSFDVTDTVRE . :: :: ..:.:. ::.... . . : ..: :: ::.: : . NP_001 YKDYIRERFDNETFRISVYQVLQ--EHLGRESDLFLLDSRTLWASEEGWLVFDITATSNH 180 190 200 210 220 230 220 230 240 250 260 pF1KE1 WLLRRESNLGLEISIHC-PCHTFQPNGDIL------ENIHEVMEIKFKGVDNEDDHGRGD :.. . ::::..:.. ....:. : .: . : ::... . :. NP_001 WVVNPRHNLGLQLSVETLDGQSINPKLAGLIGRHGPQNKQPFMVAFFKATEVHFRSIRST 240 250 260 270 280 290 270 280 290 300 310 320 pF1KE1 LGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKRALDTNYCFRNLEENCCVRPLYID .. ..:. ..:. . :. : ..... .: . : . ::.. NP_001 GSKQRSQNRSKTPKNQEAL----RMANVAENSSSDQR------------QACKKHELYVS 300 310 320 330 330 340 350 360 370 pF1KE1 FRQDLGWK-WVHEPKGYYANFCSGPCPY-LRS--ADTTHSTVLGLYNTLNPEASASPCCV :: ::::. :. :.:: : .: : : . : : :.:. : : . .:::. .:::. NP_001 FR-DLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCA 340 350 360 370 380 390 380 390 400 410 pF1KE1 PQDLEPLTILYYVGRTPKV-EQLSNMVVKSCKCS : .:. ...::. . . .. ::::..: : NP_001 PTQLNAISVLYFDDSSNVILKKYRNMVVRACGCH 400 410 420 430 >>XP_016867665 (OMIM: 147290) PREDICTED: inhibin beta A (426 aa) initn: 285 init1: 129 opt: 317 Z-score: 393.5 bits: 81.8 E(85289): 3.5e-15 Smith-Waterman score: 412; 26.7% identity (56.6% similar) in 408 aa overlap (31-412:46-426) 10 20 30 40 50 60 pF1KE1 MKMHLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEPT : . . . :::.. .::. :.: . .: XP_016 IIVRSSPTPGSEGHSAAPDCPSCALAALPKDVPNSQPEMVEAVKKHILNMLHLKK--RPD 20 30 40 50 60 70 70 80 90 100 110 120 pF1KE1 VMTHVPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQGLAEHNEL : :: :: :. :.: : : . :: : .. .: . . . .:. XP_016 VTQPVPKA--ALLNAIRKL----H----VGKVGENGYVEIEDDIGRRAEMNELMEQTSEI 80 90 100 110 120 130 140 150 160 170 pF1KE1 AVCPK-GITSKVFRFNVSSVEKNRTNLFRAEFRV-LRVPNPSSKRNEQRIELFQILR-PD . . : . :...:..:. .. . . ::: . :.::. . :.. :.::: . :. XP_016 ITFAESGTARKTLHFEISKEGSDLSVVERAEVWLFLKVPKANRTRTKVTIRLFQQQKHPQ 130 140 150 160 170 180 180 190 200 210 220 pF1KE1 EHI-----AKQRYIGG---------KNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEI . :.. . : : . .: .. : : :...... : . .:.: ..: XP_016 GSLDTGEEAEEVGLKGERSELLLSEKVVDARKST-WHVFPVSSSIQRLLDQGKSSLDVRI 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE1 SIHCPCHTFQPNGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMI . :. : .: : . . . . .: .. :.: : ..... : : .::. XP_016 A----CEQCQESGASLVLLGKKKKKEEEGEGKKKGGGEGGAGADEEKEQSHRP--FLMLQ 250 260 270 280 290 290 300 310 320 330 340 pF1KE1 PPHRLDNPGQGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWK-WVHEPKGYYAN . :.: .:..:.:. . :. :: . ....:. :.::. :. :.::.:: XP_016 ARQSEDHPH---RRRRRGLECDGKV-NI---CCKKQFFVSFK-DIGWNDWIIAPSGYHAN 300 310 320 330 340 350 360 370 380 390 pF1KE1 FCSGPCP-YLR----SADTTHSTVLGLYNTL--NPEASASPCCVPQDLEPLTILYYV-GR .: : :: .. :. . ::::.. : .: :. . :::: :.:...::: :. XP_016 YCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQ 350 360 370 380 390 400 400 410 pF1KE1 TPKVEQLSNMVVKSCKCS . ....::.:. : :: XP_016 NIIKKDIQNMIVEECGCS 410 420 >>NP_002183 (OMIM: 147290) inhibin beta A chain prepropr (426 aa) initn: 285 init1: 129 opt: 317 Z-score: 393.5 bits: 81.8 E(85289): 3.5e-15 Smith-Waterman score: 412; 26.7% identity (56.6% similar) in 408 aa overlap (31-412:46-426) 10 20 30 40 50 60 pF1KE1 MKMHLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEPT : . . . :::.. .::. :.: . .: NP_002 IIVRSSPTPGSEGHSAAPDCPSCALAALPKDVPNSQPEMVEAVKKHILNMLHLKK--RPD 20 30 40 50 60 70 70 80 90 100 110 120 pF1KE1 VMTHVPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQGLAEHNEL : :: :: :. :.: : : . :: : .. .: . . . .:. NP_002 VTQPVPKA--ALLNAIRKL----H----VGKVGENGYVEIEDDIGRRAEMNELMEQTSEI 80 90 100 110 120 130 140 150 160 170 pF1KE1 AVCPK-GITSKVFRFNVSSVEKNRTNLFRAEFRV-LRVPNPSSKRNEQRIELFQILR-PD . . : . :...:..:. .. . . ::: . :.::. . :.. :.::: . :. NP_002 ITFAESGTARKTLHFEISKEGSDLSVVERAEVWLFLKVPKANRTRTKVTIRLFQQQKHPQ 130 140 150 160 170 180 180 190 200 210 220 pF1KE1 EHI-----AKQRYIGG---------KNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEI . :.. . : : . .: .. : : :...... : . .:.: ..: NP_002 GSLDTGEEAEEVGLKGERSELLLSEKVVDARKST-WHVFPVSSSIQRLLDQGKSSLDVRI 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE1 SIHCPCHTFQPNGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMI . :. : .: : . . . . .: .. :.: : ..... : : .::. NP_002 A----CEQCQESGASLVLLGKKKKKEEEGEGKKKGGGEGGAGADEEKEQSHRP--FLMLQ 250 260 270 280 290 290 300 310 320 330 340 pF1KE1 PPHRLDNPGQGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWK-WVHEPKGYYAN . :.: .:..:.:. . :. :: . ....:. :.::. :. :.::.:: NP_002 ARQSEDHPH---RRRRRGLECDGKV-NI---CCKKQFFVSFK-DIGWNDWIIAPSGYHAN 300 310 320 330 340 350 360 370 380 390 pF1KE1 FCSGPCP-YLR----SADTTHSTVLGLYNTL--NPEASASPCCVPQDLEPLTILYYV-GR .: : :: .. :. . ::::.. : .: :. . :::: :.:...::: :. NP_002 YCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQ 350 360 370 380 390 400 400 410 pF1KE1 TPKVEQLSNMVVKSCKCS . ....::.:. : :: NP_002 NIIKKDIQNMIVEECGCS 410 420 412 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 14:24:29 2016 done: Sun Nov 6 14:24:31 2016 Total Scan time: 8.590 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]