FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3234, 546 aa 1>>>pF1KE3234 546 - 546 aa - 546 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.9363+/-0.000396; mu= 16.7027+/- 0.025 mean_var=146.8381+/-31.576, 0's: 0 Z-trim(116.5): 247 B-trim: 965 in 2/49 Lambda= 0.105841 statistics sampled from 27460 (27802) to 27460 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.684), E-opt: 0.2 (0.326), width: 16 Scan time: 10.630 The best scores are: opt bits E(85289) NP_001156956 (OMIM: 613317) DDB1- and CUL4-associa ( 546) 3747 584.5 2.8e-166 NP_079506 (OMIM: 613317) DDB1- and CUL4-associated ( 546) 3747 584.5 2.8e-166 NP_852002 (OMIM: 613317) DDB1- and CUL4-associated ( 520) 3306 517.2 5e-146 NP_004805 (OMIM: 607797) U5 small nuclear ribonucl ( 357) 296 57.3 9.1e-08 NP_056975 (OMIM: 605585) pre-mRNA-processing facto ( 579) 242 49.4 3.7e-05 NP_438172 (OMIM: 609012) WD repeat-containing prot ( 334) 238 48.5 4e-05 XP_005272220 (OMIM: 609012) PREDICTED: WD repeat-c ( 334) 238 48.5 4e-05 NP_060058 (OMIM: 609012) WD repeat-containing prot ( 334) 238 48.5 4e-05 NP_001093207 (OMIM: 616850) WD repeat domain-conta ( 315) 215 44.9 0.00044 NP_115708 (OMIM: 616850) WD repeat domain-containi ( 315) 215 44.9 0.00044 XP_016878126 (OMIM: 609540) PREDICTED: WD repeat-c ( 270) 209 43.9 0.00076 XP_005247749 (OMIM: 610863,615185) PREDICTED: guan ( 340) 210 44.2 0.00079 NP_067642 (OMIM: 610863,615185) guanine nucleotide ( 340) 210 44.2 0.00079 XP_006713784 (OMIM: 610863,615185) PREDICTED: guan ( 340) 210 44.2 0.00079 NP_002065 (OMIM: 139380,613065,616973) guanine nuc ( 340) 207 43.7 0.0011 XP_016856548 (OMIM: 139380,613065,616973) PREDICTE ( 340) 207 43.7 0.0011 NP_001269468 (OMIM: 139380,613065,616973) guanine ( 340) 207 43.7 0.0011 XP_016856549 (OMIM: 139380,613065,616973) PREDICTE ( 340) 207 43.7 0.0011 XP_016856550 (OMIM: 139380,613065,616973) PREDICTE ( 340) 207 43.7 0.0011 NP_001269467 (OMIM: 139380,613065,616973) guanine ( 240) 200 42.5 0.0018 NP_002066 (OMIM: 139130,145500,617024) guanine nuc ( 340) 201 42.8 0.0021 NP_001271137 (OMIM: 603812) DDB1- and CUL4-associa ( 326) 200 42.6 0.0022 XP_006720360 (OMIM: 603812) PREDICTED: DDB1- and C ( 977) 206 44.1 0.0023 NP_001309196 (OMIM: 607795,615922) U4/U6 small nuc ( 279) 198 42.2 0.0025 NP_001309195 (OMIM: 607795,615922) U4/U6 small nuc ( 279) 198 42.2 0.0025 XP_006720361 (OMIM: 603812) PREDICTED: DDB1- and C ( 976) 203 43.7 0.0032 NP_001231855 (OMIM: 607795,615922) U4/U6 small nuc ( 521) 198 42.6 0.0037 NP_004688 (OMIM: 607795,615922) U4/U6 small nuclea ( 522) 198 42.6 0.0037 NP_003852 (OMIM: 603812) DDB1- and CUL4-associated ( 942) 200 43.2 0.0043 NP_001271135 (OMIM: 603812) DDB1- and CUL4-associa ( 941) 197 42.7 0.0059 NP_001284500 (OMIM: 139130,145500,617024) guanine ( 339) 190 41.1 0.0066 >>NP_001156956 (OMIM: 613317) DDB1- and CUL4-associated (546 aa) initn: 3747 init1: 3747 opt: 3747 Z-score: 3106.3 bits: 584.5 E(85289): 2.8e-166 Smith-Waterman score: 3747; 99.8% identity (100.0% similar) in 546 aa overlap (1-546:1-546) 10 20 30 40 50 60 pF1KE3 MGSRNSSSAGSGSGDPSEGLPRRGAGLRRSEEEEEEDEDVDLAQVLAYLLRRGQVRLVQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGSRNSSSAGSGSGDPSEGLPRRGAGLRRSEEEEEEDEDVDLAQVLAYLLRRGQVRLVQG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 GGAANLQFIQALLDSEEENDRAWDGRLGDRYNPPVDATPDTRELEFNEIKTQVELATGQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GGAANLQFIQALLDSEEENDRAWDGRLGDRYNPPVDATPDTRELEFNEIKTQVELATGQL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 GLRRAAQKHSFPRMLHQRERGLCHRGSFSLGEQSRVISHFLPNDLGFTDSYSQKAFCGIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLRRAAQKHSFPRMLHQRERGLCHRGSFSLGEQSRVISHFLPNDLGFTDSYSQKAFCGIY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 SKDGQIFMSACQDQTIRLYDCRYGRFHKFKSIKARDVGWSVLDVAFTPDGNHFLYSSWSD ::::::::::::::::::::::::::.::::::::::::::::::::::::::::::::: NP_001 SKDGQIFMSACQDQTIRLYDCRYGRFRKFKSIKARDVGWSVLDVAFTPDGNHFLYSSWSD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 YIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 LQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 IDSKGDARYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQQNWDYRWQQVPKKAWRKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IDSKGDARYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQQNWDYRWQQVPKKAWRKL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 KLPGDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLPGDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 NHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYRQAEYFQDDMPESEECASAPAPVPQSST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYRQAEYFQDDMPESEECASAPAPVPQSST 490 500 510 520 530 540 pF1KE3 PFSSPQ :::::: NP_001 PFSSPQ >>NP_079506 (OMIM: 613317) DDB1- and CUL4-associated fac (546 aa) initn: 3747 init1: 3747 opt: 3747 Z-score: 3106.3 bits: 584.5 E(85289): 2.8e-166 Smith-Waterman score: 3747; 99.8% identity (100.0% similar) in 546 aa overlap (1-546:1-546) 10 20 30 40 50 60 pF1KE3 MGSRNSSSAGSGSGDPSEGLPRRGAGLRRSEEEEEEDEDVDLAQVLAYLLRRGQVRLVQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 MGSRNSSSAGSGSGDPSEGLPRRGAGLRRSEEEEEEDEDVDLAQVLAYLLRRGQVRLVQG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 GGAANLQFIQALLDSEEENDRAWDGRLGDRYNPPVDATPDTRELEFNEIKTQVELATGQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 GGAANLQFIQALLDSEEENDRAWDGRLGDRYNPPVDATPDTRELEFNEIKTQVELATGQL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 GLRRAAQKHSFPRMLHQRERGLCHRGSFSLGEQSRVISHFLPNDLGFTDSYSQKAFCGIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 GLRRAAQKHSFPRMLHQRERGLCHRGSFSLGEQSRVISHFLPNDLGFTDSYSQKAFCGIY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 SKDGQIFMSACQDQTIRLYDCRYGRFHKFKSIKARDVGWSVLDVAFTPDGNHFLYSSWSD ::::::::::::::::::::::::::.::::::::::::::::::::::::::::::::: NP_079 SKDGQIFMSACQDQTIRLYDCRYGRFRKFKSIKARDVGWSVLDVAFTPDGNHFLYSSWSD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 YIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 YIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 LQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 LQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 IDSKGDARYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQQNWDYRWQQVPKKAWRKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 IDSKGDARYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQQNWDYRWQQVPKKAWRKL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 KLPGDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 KLPGDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 NHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYRQAEYFQDDMPESEECASAPAPVPQSST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 NHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYRQAEYFQDDMPESEECASAPAPVPQSST 490 500 510 520 530 540 pF1KE3 PFSSPQ :::::: NP_079 PFSSPQ >>NP_852002 (OMIM: 613317) DDB1- and CUL4-associated fac (520 aa) initn: 3306 init1: 3306 opt: 3306 Z-score: 2742.6 bits: 517.2 E(85289): 5e-146 Smith-Waterman score: 3521; 95.1% identity (95.2% similar) in 546 aa overlap (1-546:1-520) 10 20 30 40 50 60 pF1KE3 MGSRNSSSAGSGSGDPSEGLPRRGAGLRRSEEEEEEDEDVDLAQVLAYLLRRGQVRLVQG :::::::::::::::::::::::::::::::::::::::::::: NP_852 MGSRNSSSAGSGSGDPSEGLPRRGAGLRRSEEEEEEDEDVDLAQ---------------- 10 20 30 40 70 80 90 100 110 120 pF1KE3 GGAANLQFIQALLDSEEENDRAWDGRLGDRYNPPVDATPDTRELEFNEIKTQVELATGQL :::::::::::::::::::::::::::::::::::::::::::::::::: NP_852 ----------ALLDSEEENDRAWDGRLGDRYNPPVDATPDTRELEFNEIKTQVELATGQL 50 60 70 80 90 130 140 150 160 170 180 pF1KE3 GLRRAAQKHSFPRMLHQRERGLCHRGSFSLGEQSRVISHFLPNDLGFTDSYSQKAFCGIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_852 GLRRAAQKHSFPRMLHQRERGLCHRGSFSLGEQSRVISHFLPNDLGFTDSYSQKAFCGIY 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE3 SKDGQIFMSACQDQTIRLYDCRYGRFHKFKSIKARDVGWSVLDVAFTPDGNHFLYSSWSD ::::::::::::::::::::::::::.::::::::::::::::::::::::::::::::: NP_852 SKDGQIFMSACQDQTIRLYDCRYGRFRKFKSIKARDVGWSVLDVAFTPDGNHFLYSSWSD 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE3 YIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_852 YIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRT 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE3 LQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_852 LQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITF 280 290 300 310 320 330 370 380 390 400 410 420 pF1KE3 IDSKGDARYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQQNWDYRWQQVPKKAWRKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_852 IDSKGDARYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQQNWDYRWQQVPKKAWRKL 340 350 360 370 380 390 430 440 450 460 470 480 pF1KE3 KLPGDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_852 KLPGDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLT 400 410 420 430 440 450 490 500 510 520 530 540 pF1KE3 NHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYRQAEYFQDDMPESEECASAPAPVPQSST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_852 NHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYRQAEYFQDDMPESEECASAPAPVPQSST 460 470 480 490 500 510 pF1KE3 PFSSPQ :::::: NP_852 PFSSPQ 520 >>NP_004805 (OMIM: 607797) U5 small nuclear ribonucleopr (357 aa) initn: 362 init1: 130 opt: 296 Z-score: 260.4 bits: 57.3 E(85289): 9.1e-08 Smith-Waterman score: 315; 25.7% identity (56.2% similar) in 338 aa overlap (174-509:68-353) 150 160 170 180 190 200 pF1KE3 HRGSFSLGEQSRVISHFLPNDLGFTDSYSQKAFCGIYSKDGQIFMSACQDQTIRLYDCRY ...: . .:. . :: :. : :.. : NP_004 QATPGALLQAGPPRCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNV-Y 40 50 60 70 80 90 210 220 230 240 250 260 pF1KE3 GRFHKFKSIKARDVGWSVLDVAFTPDGNHFLYSSWSDYIHICNIYGEGDTHTALDLRPDE : .. ..:... : .:... .. ::. .:.:. .: . .. ...: . . NP_004 GDCDNYATLKGHS-G-AVMELHYNTDGS-MLFSASTD--KTVAVW-DSETGERVKRLKGH 100 110 120 130 140 150 270 280 290 300 310 320 pF1KE3 RRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQIL :. . . : :..:: . ..: .. . ..: .. .: ::.: : :.::. NP_004 TSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRK-KAAIQTFQNTYQVLAVTFNDTSDQII 160 170 180 190 200 330 340 350 360 370 380 pF1KE3 FSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWD ::: : :::: .:.. : . .. :: :..: .. .... ::.::. :.:...:: NP_004 -SGGIDNDIKVWD---LRQN--KLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWD 210 220 230 240 250 260 390 400 410 420 430 440 pF1KE3 IRRFSSREGMEASRQAATQQNWDYRWQQVPKKAWRKLKLPGDSSLMTYRG--HGVLHTLI .: :. .: : .:. ..: :. ..:. NP_004 VRPFAPKE--------------------------RCVKI--------FQGNVHNFEKNLL 270 280 450 460 470 480 490 500 pF1KE3 RCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVSS :: .:: :.. : .: . : :.: : .:. :: .: . . .:..:: : :.:. NP_004 RCSWSP---DGSK-IAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISA 290 300 310 320 330 340 510 520 530 540 pF1KE3 SWDGNLRLWQYRQAEYFQDDMPESEECASAPAPVPQSSTPFSSPQ : : : . NP_004 SSDKRLYMGEIQ 350 >>NP_056975 (OMIM: 605585) pre-mRNA-processing factor 17 (579 aa) initn: 141 init1: 73 opt: 242 Z-score: 213.5 bits: 49.4 E(85289): 3.7e-05 Smith-Waterman score: 242; 24.4% identity (55.4% similar) in 307 aa overlap (224-510:294-578) 200 210 220 230 240 250 pF1KE3 QTIRLYDCRYGRFHKFKSIKARDVGWSVLDVAFTPDGNHFLYSSWSD-YIHICNIYGEGD : . : ..:.: : : :.. ..::: NP_056 NLRSTMPPEKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGE-- 270 280 290 300 310 320 260 270 280 290 300 310 pF1KE3 THTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNA . : . . :: .: .. : . :..: : : ..: : .. .. ... . NP_056 -RRCLRTFIGHSK-AVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCV 330 340 350 360 370 320 330 340 350 360 pF1KE3 VAFADISSQILFSGG--DDAICKVWDRRT--MREDDPKPVGALAGHQDGITFIDSKGDAR : ..: :: .: : : . :: :. . .. . .::. . :.:.: . : NP_056 KFNPDEDKQNLFVAGMSDKKIVQ-WDIRSGEIVQEYDRHLGAV----NTIVFVD---ENR 380 390 400 410 420 430 370 380 390 400 410 pF1KE3 YLISNSKDQTIKLW--DIR---RFSSREGMEASRQAATQQNWDYRW---QQVPKK----- ..:.: :.....: :: .. .. .:.. . :. . . .: :.. .. NP_056 RFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHS--MPAVTLSPNGKWLACQSMDNQILIFG 440 450 460 470 480 420 430 440 450 460 470 pF1KE3 AWRKLKLPGDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHI : ...: .. ..:: : . ::: : .. :: ..::. ..: . .. NP_056 AQNRFRL---NKKKIFKGHMVAGYACQVDFSPDMS----YVISGDGNGKLNIWDWKTTKL 490 500 510 520 530 540 480 490 500 510 520 530 pF1KE3 VKKLTNH-KACVRDVSWHPFEE-KIVSSSWDGNLRLWQYRQAEYFQDDMPESEECASAPA ... : :.:. : ::: : :... .::: ..:: NP_056 YSRFKAHDKVCIGAV-WHPHETSKVITCGWDGLIKLWD 550 560 570 540 pF1KE3 PVPQSSTPFSSPQ >>NP_438172 (OMIM: 609012) WD repeat-containing protein (334 aa) initn: 302 init1: 113 opt: 238 Z-score: 212.9 bits: 48.5 E(85289): 4e-05 Smith-Waterman score: 285; 23.9% identity (51.7% similar) in 360 aa overlap (162-511:33-331) 140 150 160 170 180 pF1KE3 PRMLHQRERGLCHRGSFSLGEQSRVISHFLPN-DLGFTDSYSQKAFCGI-YSKDGQIFMS :: : :: . :: .. .: .:. . : NP_438 TEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLAS 10 20 30 40 50 60 190 200 210 220 230 240 pF1KE3 ACQDQTIRLYDCRYGRFHKFKSIKARDVGWSVLDVAFTPDGNHFLYSSWSDYIHICNIYG . :. :... :.:. :.:... .: : :::.. :.: .. .: . ..: .. . NP_438 SSADKLIKIWGAYDGKFE--KTISGHKLGIS--DVAWSSDSNLLVSASDDKTLKIWDV-S 70 80 90 100 110 250 260 270 280 290 300 pF1KE3 EGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDD : .: . . :: . .. ...:. : . ..: . .. . .: : NP_438 SGKCLKTLKGHSNY----VFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDP 120 130 140 150 160 170 310 320 330 340 350 360 pF1KE3 VNAVAFADISSQILFSGGDDAICKVWDR------RTMREDDPKPVGALAGHQDGITFIDS :.:: : .: :. :.. :..:..:: .:. .:: :: .:. NP_438 VSAVHFNRDGSLIV-SSSYDGLCRIWDTASGQCLKTLIDDDNPPV----------SFVKF 180 190 200 210 220 370 380 390 400 410 420 pF1KE3 KGDARYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQQNWDYRWQQVPKKAWRKLKLP . ...:... . :.:.:::: . NP_438 SPNGKYILAATLDNTLKLWDYSK------------------------------------- 230 240 430 440 450 460 470 480 pF1KE3 GDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHK . : :: :: .. : :. . :: ..: :: . : ...: . .::.:: .: NP_438 -GKCLKTYTGH---KNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHT 250 260 270 280 290 300 490 500 510 520 530 540 pF1KE3 ACVRDVSWHPFEEKIVSSSW--DGNLRLWQYRQAEYFQDDMPESEECASAPAPVPQSSTP : ... :: :. :.:.. : ...::. NP_438 DVVISTACHPTENIIASAALENDKTIKLWKSDC 310 320 330 >>XP_005272220 (OMIM: 609012) PREDICTED: WD repeat-conta (334 aa) initn: 302 init1: 113 opt: 238 Z-score: 212.9 bits: 48.5 E(85289): 4e-05 Smith-Waterman score: 285; 23.9% identity (51.7% similar) in 360 aa overlap (162-511:33-331) 140 150 160 170 180 pF1KE3 PRMLHQRERGLCHRGSFSLGEQSRVISHFLPN-DLGFTDSYSQKAFCGI-YSKDGQIFMS :: : :: . :: .. .: .:. . : XP_005 TEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLAS 10 20 30 40 50 60 190 200 210 220 230 240 pF1KE3 ACQDQTIRLYDCRYGRFHKFKSIKARDVGWSVLDVAFTPDGNHFLYSSWSDYIHICNIYG . :. :... :.:. :.:... .: : :::.. :.: .. .: . ..: .. . XP_005 SSADKLIKIWGAYDGKFE--KTISGHKLGIS--DVAWSSDSNLLVSASDDKTLKIWDV-S 70 80 90 100 110 250 260 270 280 290 300 pF1KE3 EGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDD : .: . . :: . .. ...:. : . ..: . .. . .: : XP_005 SGKCLKTLKGHSNY----VFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDP 120 130 140 150 160 170 310 320 330 340 350 360 pF1KE3 VNAVAFADISSQILFSGGDDAICKVWDR------RTMREDDPKPVGALAGHQDGITFIDS :.:: : .: :. :.. :..:..:: .:. .:: :: .:. XP_005 VSAVHFNRDGSLIV-SSSYDGLCRIWDTASGQCLKTLIDDDNPPV----------SFVKF 180 190 200 210 220 370 380 390 400 410 420 pF1KE3 KGDARYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQQNWDYRWQQVPKKAWRKLKLP . ...:... . :.:.:::: . XP_005 SPNGKYILAATLDNTLKLWDYSK------------------------------------- 230 240 430 440 450 460 470 480 pF1KE3 GDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHK . : :: :: .. : :. . :: ..: :: . : ...: . .::.:: .: XP_005 -GKCLKTYTGH---KNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHT 250 260 270 280 290 300 490 500 510 520 530 540 pF1KE3 ACVRDVSWHPFEEKIVSSSW--DGNLRLWQYRQAEYFQDDMPESEECASAPAPVPQSSTP : ... :: :. :.:.. : ...::. XP_005 DVVISTACHPTENIIASAALENDKTIKLWKSDC 310 320 330 >>NP_060058 (OMIM: 609012) WD repeat-containing protein (334 aa) initn: 302 init1: 113 opt: 238 Z-score: 212.9 bits: 48.5 E(85289): 4e-05 Smith-Waterman score: 285; 23.9% identity (51.7% similar) in 360 aa overlap (162-511:33-331) 140 150 160 170 180 pF1KE3 PRMLHQRERGLCHRGSFSLGEQSRVISHFLPN-DLGFTDSYSQKAFCGI-YSKDGQIFMS :: : :: . :: .. .: .:. . : NP_060 TEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLAS 10 20 30 40 50 60 190 200 210 220 230 240 pF1KE3 ACQDQTIRLYDCRYGRFHKFKSIKARDVGWSVLDVAFTPDGNHFLYSSWSDYIHICNIYG . :. :... :.:. :.:... .: : :::.. :.: .. .: . ..: .. . NP_060 SSADKLIKIWGAYDGKFE--KTISGHKLGIS--DVAWSSDSNLLVSASDDKTLKIWDV-S 70 80 90 100 110 250 260 270 280 290 300 pF1KE3 EGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDD : .: . . :: . .. ...:. : . ..: . .. . .: : NP_060 SGKCLKTLKGHSNY----VFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDP 120 130 140 150 160 170 310 320 330 340 350 360 pF1KE3 VNAVAFADISSQILFSGGDDAICKVWDR------RTMREDDPKPVGALAGHQDGITFIDS :.:: : .: :. :.. :..:..:: .:. .:: :: .:. NP_060 VSAVHFNRDGSLIV-SSSYDGLCRIWDTASGQCLKTLIDDDNPPV----------SFVKF 180 190 200 210 220 370 380 390 400 410 420 pF1KE3 KGDARYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQQNWDYRWQQVPKKAWRKLKLP . ...:... . :.:.:::: . NP_060 SPNGKYILAATLDNTLKLWDYSK------------------------------------- 230 240 430 440 450 460 470 480 pF1KE3 GDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHK . : :: :: .. : :. . :: ..: :: . : ...: . .::.:: .: NP_060 -GKCLKTYTGH---KNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHT 250 260 270 280 290 300 490 500 510 520 530 540 pF1KE3 ACVRDVSWHPFEEKIVSSSW--DGNLRLWQYRQAEYFQDDMPESEECASAPAPVPQSSTP : ... :: :. :.:.. : ...::. NP_060 DVVISTACHPTENIIASAALENDKTIKLWKSDC 310 320 330 >>NP_001093207 (OMIM: 616850) WD repeat domain-containin (315 aa) initn: 154 init1: 70 opt: 215 Z-score: 194.2 bits: 44.9 E(85289): 0.00044 Smith-Waterman score: 224; 23.0% identity (52.7% similar) in 317 aa overlap (210-521:16-312) 180 190 200 210 220 230 pF1KE3 YSKDGQIFMSACQDQTIRLYDCRYGRFHKFKSIKARDVGW-SVLDVAFTPDGNHFLYSSW : .:. : : .: : :. :::. : . NP_001 MAFPEPKPRPPELPQKRLKTLDCGQGAVRAVRFNVDGNYCLTCGS 10 20 30 40 240 250 260 270 280 290 pF1KE3 SDYIHICN-IYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQN . ... : . : : : . . :.. : : :. . .:..: . ..: .. NP_001 DKTLKLWNPLRG-----TLLRTYSGHG-YEVLDAAGSFDNSSLCSGGGDKAVVLWDVASG 50 60 70 80 90 300 310 320 330 340 350 pF1KE3 RRTLQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDG . . ....: ::.: : . . ...::. :. . :: :. : :.:: .: .:: NP_001 QVVRKFRGHAGKVNTVQFNE-EATVILSGSIDSSIRCWDCRSRR---PEPVQTLDEARDG 100 110 120 130 140 150 360 370 380 390 400 410 pF1KE3 ITFIDSKGDARYLISNSKDQTIKLWDIRR---FSSREGMEASRQAATQQNWDYRWQQVPK .. . : . . ....: : .. .:.: ::. : . .... ... . NP_001 VSSV--KVSDHEILAGSVDGRVRRYDLRMGQLFSDYVGSPITCTCFSRDGQCTLVSSLDS 160 170 180 190 200 210 420 430 440 450 460 470 pF1KE3 KAWRKLKLPGDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGH . : : : :.:: . . : .: . . : ::: .::. : NP_001 -TLRLLDKDTGELLGEYKGHKNQEYKLDCCLSERDT----HVVSCSEDGKVFFWDLVEGA 220 230 240 250 260 480 490 500 510 520 530 pF1KE3 IVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYRQAEYFQDDMPESEECASAPAP .. : .. :.....:: : .... :... : :. : .: NP_001 LALALPVGSGVVQSLAYHPTEPCLLTA-MGGSVQCW--REEAYEAEDGAG 270 280 290 300 310 540 pF1KE3 VPQSSTPFSSPQ >>NP_115708 (OMIM: 616850) WD repeat domain-containing p (315 aa) initn: 154 init1: 70 opt: 215 Z-score: 194.2 bits: 44.9 E(85289): 0.00044 Smith-Waterman score: 224; 23.0% identity (52.7% similar) in 317 aa overlap (210-521:16-312) 180 190 200 210 220 230 pF1KE3 YSKDGQIFMSACQDQTIRLYDCRYGRFHKFKSIKARDVGW-SVLDVAFTPDGNHFLYSSW : .:. : : .: : :. :::. : . NP_115 MAFPEPKPRPPELPQKRLKTLDCGQGAVRAVRFNVDGNYCLTCGS 10 20 30 40 240 250 260 270 280 290 pF1KE3 SDYIHICN-IYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQN . ... : . : : : . . :.. : : :. . .:..: . ..: .. NP_115 DKTLKLWNPLRG-----TLLRTYSGHG-YEVLDAAGSFDNSSLCSGGGDKAVVLWDVASG 50 60 70 80 90 300 310 320 330 340 350 pF1KE3 RRTLQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDG . . ....: ::.: : . . ...::. :. . :: :. : :.:: .: .:: NP_115 QVVRKFRGHAGKVNTVQFNE-EATVILSGSIDSSIRCWDCRSRR---PEPVQTLDEARDG 100 110 120 130 140 150 360 370 380 390 400 410 pF1KE3 ITFIDSKGDARYLISNSKDQTIKLWDIRR---FSSREGMEASRQAATQQNWDYRWQQVPK .. . : . . ....: : .. .:.: ::. : . .... ... . NP_115 VSSV--KVSDHEILAGSVDGRVRRYDLRMGQLFSDYVGSPITCTCFSRDGQCTLVSSLDS 160 170 180 190 200 210 420 430 440 450 460 470 pF1KE3 KAWRKLKLPGDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGH . : : : :.:: . . : .: . . : ::: .::. : NP_115 -TLRLLDKDTGELLGEYKGHKNQEYKLDCCLSERDT----HVVSCSEDGKVFFWDLVEGA 220 230 240 250 260 480 490 500 510 520 530 pF1KE3 IVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYRQAEYFQDDMPESEECASAPAP .. : .. :.....:: : .... :... : :. : .: NP_115 LALALPVGSGVVQSLAYHPTEPCLLTA-MGGSVQCW--REEAYEAEDGAG 270 280 290 300 310 540 pF1KE3 VPQSSTPFSSPQ 546 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 14:29:17 2016 done: Sun Nov 6 14:29:18 2016 Total Scan time: 10.630 Total Display time: 0.080 Function used was FASTA [36.3.4 Apr, 2011]