FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1245, 477 aa 1>>>pF1KE1245 477 - 477 aa - 477 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.3841+/-0.000345; mu= 8.4760+/- 0.022 mean_var=286.1569+/-59.487, 0's: 0 Z-trim(124.8): 481 B-trim: 4407 in 2/60 Lambda= 0.075818 statistics sampled from 46751 (47356) to 46751 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.812), E-opt: 0.2 (0.555), width: 16 Scan time: 11.210 The best scores are: opt bits E(85289) NP_000675 (OMIM: 109630,607276) beta-1 adrenergic ( 477) 3257 369.2 1.5e-101 NP_000015 (OMIM: 109690,600807,601665) beta-2 adre ( 413) 977 119.7 1.6e-26 NP_000016 (OMIM: 109691,601665) beta-3 adrenergic ( 408) 886 109.7 1.5e-23 NP_000854 (OMIM: 182131) 5-hydroxytryptamine recep ( 390) 690 88.3 4.3e-17 NP_000855 (OMIM: 182133) 5-hydroxytryptamine recep ( 377) 644 83.2 1.4e-15 NP_000856 (OMIM: 182132) 5-hydroxytryptamine recep ( 365) 634 82.1 2.9e-15 XP_011534091 (OMIM: 182132) PREDICTED: 5-hydroxytr ( 365) 634 82.1 2.9e-15 NP_387512 (OMIM: 126451,181500,190300) D(3) dopami ( 367) 604 78.8 2.8e-14 NP_001309139 (OMIM: 182134) 5-hydroxytryptamine re ( 366) 571 75.2 3.4e-13 NP_001309137 (OMIM: 182134) 5-hydroxytryptamine re ( 366) 571 75.2 3.4e-13 NP_001309138 (OMIM: 182134) 5-hydroxytryptamine re ( 366) 571 75.2 3.4e-13 NP_000857 (OMIM: 182134) 5-hydroxytryptamine recep ( 366) 571 75.2 3.4e-13 XP_005264808 (OMIM: 182134) PREDICTED: 5-hydroxytr ( 366) 571 75.2 3.4e-13 XP_011531966 (OMIM: 182134) PREDICTED: 5-hydroxytr ( 366) 571 75.2 3.4e-13 NP_000785 (OMIM: 126449) D(1A) dopamine receptor [ ( 446) 570 75.2 4.2e-13 XP_006712545 (OMIM: 601122) PREDICTED: 5-hydroxytr ( 456) 529 70.7 9.5e-12 NP_001307687 (OMIM: 601122) 5-hydroxytryptamine re ( 439) 522 69.9 1.6e-11 NP_000669 (OMIM: 104219) alpha-1D adrenergic recep ( 572) 524 70.3 1.6e-11 NP_000858 (OMIM: 601122) 5-hydroxytryptamine recep ( 481) 522 70.0 1.7e-11 NP_071640 (OMIM: 142703) histamine H2 receptor iso ( 359) 509 68.4 3.7e-11 XP_006714928 (OMIM: 142703) PREDICTED: histamine H ( 362) 509 68.4 3.7e-11 NP_001124527 (OMIM: 142703) histamine H2 receptor ( 397) 509 68.5 3.9e-11 XP_005265961 (OMIM: 142703) PREDICTED: histamine H ( 422) 509 68.5 4.1e-11 XP_011532851 (OMIM: 142703) PREDICTED: histamine H ( 422) 509 68.5 4.1e-11 XP_016864915 (OMIM: 142703) PREDICTED: histamine H ( 422) 509 68.5 4.1e-11 XP_011532850 (OMIM: 142703) PREDICTED: histamine H ( 422) 509 68.5 4.1e-11 XP_006714927 (OMIM: 142703) PREDICTED: histamine H ( 422) 509 68.5 4.1e-11 XP_005265876 (OMIM: 104220) PREDICTED: alpha-1B ad ( 328) 506 68.0 4.4e-11 XP_006714884 (OMIM: 104220) PREDICTED: alpha-1B ad ( 331) 506 68.0 4.4e-11 XP_005265875 (OMIM: 104220) PREDICTED: alpha-1B ad ( 366) 506 68.1 4.7e-11 XP_011532740 (OMIM: 104220) PREDICTED: alpha-1B ad ( 389) 506 68.1 4.9e-11 XP_011532739 (OMIM: 104220) PREDICTED: alpha-1B ad ( 402) 506 68.2 5e-11 NP_000670 (OMIM: 104220) alpha-1B adrenergic recep ( 520) 506 68.3 5.9e-11 XP_011532737 (OMIM: 104220) PREDICTED: alpha-1B ad ( 556) 506 68.3 6.1e-11 XP_011542714 (OMIM: 104221) PREDICTED: alpha-1A ad ( 308) 497 67.0 8.3e-11 XP_016868585 (OMIM: 104221) PREDICTED: alpha-1A ad ( 317) 497 67.0 8.5e-11 XP_011542713 (OMIM: 104221) PREDICTED: alpha-1A ad ( 324) 497 67.1 8.6e-11 NP_000672 (OMIM: 104210) alpha-2A adrenergic recep ( 465) 500 67.6 8.6e-11 NP_001309433 (OMIM: 104221) alpha-1A adrenergic re ( 342) 497 67.1 8.9e-11 NP_001309432 (OMIM: 104221) alpha-1A adrenergic re ( 370) 497 67.1 9.4e-11 NP_001309431 (OMIM: 104221) alpha-1A adrenergic re ( 372) 497 67.1 9.4e-11 NP_150645 (OMIM: 104221) alpha-1A adrenergic recep ( 429) 497 67.2 1e-10 XP_006716356 (OMIM: 104221) PREDICTED: alpha-1A ad ( 429) 497 67.2 1e-10 NP_150647 (OMIM: 104221) alpha-1A adrenergic recep ( 455) 497 67.2 1.1e-10 NP_000671 (OMIM: 104221) alpha-1A adrenergic recep ( 466) 497 67.2 1.1e-10 NP_150646 (OMIM: 104221) alpha-1A adrenergic recep ( 475) 497 67.3 1.1e-10 XP_016868583 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 497 67.3 1.1e-10 XP_006716355 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 497 67.3 1.1e-10 XP_016868584 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 497 67.3 1.1e-10 NP_000862 (OMIM: 601109) 5-hydroxytryptamine recep ( 440) 490 66.4 1.8e-10 >>NP_000675 (OMIM: 109630,607276) beta-1 adrenergic rece (477 aa) initn: 3257 init1: 3257 opt: 3257 Z-score: 1944.4 bits: 369.2 E(85289): 1.5e-101 Smith-Waterman score: 3257; 99.8% identity (99.8% similar) in 477 aa overlap (1-477:1-477) 10 20 30 40 50 60 pF1KE1 MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 MGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 WGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 WGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 TVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 TVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 AFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 AFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 LANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 FFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAARRRHATHGDRPRASGCLARPGP :::::::::::::::::::::::::::: ::::::::::::::::::::::::::::::: NP_000 FFNWLGYANSAFNPIIYCRSPDFRKAFQGLLCCARRAARRRHATHGDRPRASGCLARPGP 370 380 390 400 410 420 430 440 450 460 470 pF1KE1 PPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 PPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV 430 440 450 460 470 >>NP_000015 (OMIM: 109690,600807,601665) beta-2 adrenerg (413 aa) initn: 1327 init1: 957 opt: 977 Z-score: 597.3 bits: 119.7 E(85289): 1.6e-26 Smith-Waterman score: 1313; 54.4% identity (74.9% similar) in 390 aa overlap (35-413:4-365) 10 20 30 40 50 pF1KE1 VLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPA-SESPE-PLSQQ----WT :.. : :: : :..:. ..:: :. NP_000 MGQPGNGSAFLLAPNRSHAPDHDVTQQRDEVWV 10 20 30 60 70 80 90 100 110 pF1KE1 AGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATI .:::..:.:::: :: ::::::.:::: ::::.:: :: ::: ::::::: ::::::. NP_000 VGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAH 40 50 60 70 80 90 120 130 140 150 160 170 pF1KE1 VVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGL .. : .:.:.::.:::.::::::::::::::::.:::.::::::.::::::. .:: . NP_000 ILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVI 100 110 120 130 140 150 180 190 200 210 220 230 pF1KE1 VCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLC . :: .:.:.::::: :::.:: .:: :: . :::: ::.:::::::.::::::: NP_000 ILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLV 160 170 180 190 200 210 240 250 260 270 280 290 pF1KE1 IMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAAT ::.::: :::.::..:..:::. : :: . : : NP_000 IMVFVYSRVFQEAKRQLQKIDKSEGRF-------HVQNLSQVEQ---------------- 220 230 240 250 300 310 320 330 340 350 pF1KE1 APLANGRAGK--RRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPD .::.:. :: :.. :.:.:::::::::::.:::::::::..:.:.... .:. NP_000 ----DGRTGHGLRRSSKFC-LKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRK 260 270 280 290 300 360 370 380 390 400 410 pF1KE1 RLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCAR---RAARRRHATHGDRPRASG ......::.::.::.:::.::::::::: :::.::: : .: ....:. . :: NP_000 EVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSG 310 320 330 340 350 360 420 430 440 450 460 470 pF1KE1 CLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFAS NP_000 YHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL 370 380 390 400 410 >>NP_000016 (OMIM: 109691,601665) beta-3 adrenergic rece (408 aa) initn: 839 init1: 625 opt: 886 Z-score: 543.5 bits: 109.7 E(85289): 1.5e-23 Smith-Waterman score: 1293; 52.4% identity (71.1% similar) in 422 aa overlap (10-424:2-394) 10 20 30 40 50 60 pF1KE1 MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAG : : . :: :: :: . :.: . .: :: . : : :. NP_000 MAPWPHENSSLAPWPDLPT-----LAPNTANTSGLPGV---P------WEAA 10 20 30 70 80 90 100 110 pF1KE1 M-GLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIV . : :.:: :: :.::.::::::: ::::::.::.:. :::.::::::::::: .::.. NP_000 LAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLA 40 50 60 70 80 90 120 130 140 150 160 170 pF1KE1 VWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLV . :.: :. ::::::::::::::::::::..:.:::::.:.:.:: .:.:. :: : NP_000 LTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAV 100 110 120 130 140 150 180 190 200 210 220 230 pF1KE1 CTVWAISALVSFLPILMHWWRAESD-EARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLC ::..:: ::: ::. .:::. .: ::.::...:.:: :..: :.. :: ::::.:: NP_000 VLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLL 160 170 180 190 200 210 240 250 260 270 280 290 pF1KE1 IMAFVYLRVFREAQKQVKKIDSCERRFLGGPAR-PPSPSPSPVPAPAPPPGPPRPAAAAA .: ::: ::: : .:.. . . :: : . ::.:: : .:::. .::. . : . NP_000 VMLFVYARVFVVATRQLRLLRGELGRF--PPEESPPAPSRSLAPAPVGTCAPPEGVPACG 220 230 240 250 260 270 300 310 320 330 340 350 pF1KE1 TAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRE-LVPD :::.::. :::..:: :::.:::.:::::::::::::..:. ::: NP_000 -----------RRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPG 280 290 300 310 320 360 370 380 390 400 410 pF1KE1 RLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQRLLC-CARRAARRRHATHGDRPR--ASG :. .::::::::::::.:::::::::.::.:::: :.:: . :. :: :: NP_000 PAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAA--RPALFPSG 330 340 350 360 370 380 420 430 440 450 460 470 pF1KE1 CLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFAS : . : .: NP_000 VPAARSSPAQPRLCQRLDGASWGVS 390 400 >>NP_000854 (OMIM: 182131) 5-hydroxytryptamine receptor (390 aa) initn: 588 init1: 352 opt: 690 Z-score: 427.9 bits: 88.3 E(85289): 4.3e-17 Smith-Waterman score: 690; 34.4% identity (62.6% similar) in 390 aa overlap (12-391:3-384) 10 20 30 40 50 pF1KE1 MGAGVLVLGASEPGNLSSAAPLPDGAAT-AARLLVPASPPASLLPPASESPEPLSQQWTA ::: . : : : :. : . . . ..: . . .: : . NP_000 MEEPGA-QCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKV 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 GMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIV . .:.:::.: . .:..::... .: .:.: .: .: ::: .::....::.:... . NP_000 LLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYT 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 VWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLV : ::: :. :..: : :. : :::: ::::::::: :::. .:.. : :: .. NP_000 VTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMI 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 CTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCI ::..: .:. :.. . .:: .:. .: . : . :.. :.: .:: : . NP_000 ALVWVFSISISLPPFFWRQAKAE-EEVSECVVN---TDHIL---YTVYSTVGAFYFPTLL 180 190 200 210 220 240 250 260 270 280 290 pF1KE1 MAFVYLRVFREAQKQVKKI--DSCERRFLGGPARPPSP-SPSPVPA-PAPPPGPPRPAAA . .: :.. ::.... : . .:. . :: : : : . . : : ... NP_000 LIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGS 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE1 AATAPLANGRAGKR--RPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHREL . . .. :.. . ..:.: ::.:: ::::::.:.: .::::::. ..: . .. NP_000 PVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDA 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE1 VPDRL--FVFFNWLGYANSAFNPIIYCRS-PDFRKAFQRLLCCARRAARRRHATHGDRPR .: : ::.:::: :: .::::: : ::..::..:. NP_000 CWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTS 350 360 370 380 390 420 430 440 450 460 470 pF1KE1 ASGCLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPG >>NP_000855 (OMIM: 182133) 5-hydroxytryptamine receptor (377 aa) initn: 528 init1: 313 opt: 644 Z-score: 400.9 bits: 83.2 E(85289): 1.4e-15 Smith-Waterman score: 644; 34.6% identity (66.0% similar) in 356 aa overlap (47-391:26-371) 20 30 40 50 60 70 pF1KE1 SSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLS-QQWTAGMGLLMALIVLLIVAG ::. .: . : ........:.: : . NP_000 MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLS 10 20 30 40 50 80 90 100 110 120 130 pF1KE1 NVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWT :..:...: : .:.: .: .: :::..::....::.:.. . .. :..:...:..: NP_000 NAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWL 60 70 80 90 100 110 140 150 160 170 180 190 pF1KE1 SVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPIL : :. : :::: ::::::::: :::. ..:.. : ..: .. ::::: .:. :.. NP_000 SSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLF 120 130 140 150 160 170 200 210 220 230 240 250 pF1KE1 MHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQV : .:...: ..: : ... .:.: :. .::.: .. ..: :..: :.... NP_000 --WRQAKAQEE---MSD--CLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRI 180 190 200 210 220 260 270 280 290 300 pF1KE1 KKIDSCE-RRFLGGPARPPSPSPSPVPAPAP-PPGPPRPAAAA-----ATAPLANGRAGK . : .:: . : . : . : . :.. . ::.. : . NP_000 LNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADS-ALE 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE1 RRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRE--LVPDRLFVFFNWLG :. :. : ::.:: : ::::.:.: .::::::....: . :. . :: ::.::: NP_000 RK--RISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLG 290 300 310 320 330 340 370 380 390 400 410 420 pF1KE1 YANSAFNPIIYCR-SPDFRKAFQRLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPG : :: .::::: . .::.:::... NP_000 YLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS 350 360 370 >>NP_000856 (OMIM: 182132) 5-hydroxytryptamine receptor (365 aa) initn: 576 init1: 343 opt: 634 Z-score: 395.1 bits: 82.1 E(85289): 2.9e-15 Smith-Waterman score: 634; 34.3% identity (61.8% similar) in 353 aa overlap (58-393:20-361) 30 40 50 60 70 80 pF1KE1 TAARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVL--LIVAGNVLVIVAIAK : : . :.:.:. : . :. ::.::. NP_000 MNITNCTTEASMAIRPKTITEKMLICMTLVVITTLTTLLNLAVIMAIGT 10 20 30 40 90 100 110 120 130 140 pF1KE1 TPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTAS : .:. .: .: ::: .::....::.:.. .: ::. : :.::.: :::. : : : NP_000 TKKLHQPANYLICSLAVTDLLVAVLVMPLSIIYIVMDRWKLGYFLCEVWLSVDMTCCTCS 50 60 70 80 90 100 150 160 170 180 190 200 pF1KE1 IETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDE : ::::::::: :::. ..: : :: .. :::.:: ..:. :.. ::.. NP_000 ILHLCVIALDRYWAITNAIEYARKRTAKRAALMILTVWTISIFISMPPLF---WRSH--- 110 120 130 140 150 160 210 220 230 240 250 260 pF1KE1 ARRCYNDPKCCDFVTNRA-YAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERR :: :. : . ... :.: :.. .::.:: .. ..: :... :.. .: : : NP_000 -RRLSPPPSQCTIQHDHVIYTIYSTLGAFYIPLTLILILYYRIYHAAKSLYQKRGSS--R 170 180 190 200 210 220 270 280 290 300 310 pF1KE1 FLGGPARPPSPS-----------PSPVPAPAPPPGPPRPAAAAATAPLANG--RAGKRRP :.. . . : : . : . :. :. : . :.:. NP_000 HLSNRSTDSQNSFASCKLTQTFCVSDFSTSDPTTEFEKFHASIRIPPFDNDLDHPGERQ- 230 240 250 260 270 320 330 340 350 360 370 pF1KE1 SRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSA .. . ::.:: . ::.:.:.: : :::::. ... .. : ... :..::::.:: NP_000 -QISSTRERKAARILGLILGAFILSWLPFFIKELIVGLSIYTVSSEVADFLTWLGYVNSL 280 290 300 310 320 330 380 390 400 410 420 430 pF1KE1 FNPIIYCR-SPDFRKAFQRLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDD .::..: . ::. ::..:. : NP_000 INPLLYTSFNEDFKLAFKKLIRCREHT 340 350 360 >>XP_011534091 (OMIM: 182132) PREDICTED: 5-hydroxytrypta (365 aa) initn: 576 init1: 343 opt: 634 Z-score: 395.1 bits: 82.1 E(85289): 2.9e-15 Smith-Waterman score: 634; 34.3% identity (61.8% similar) in 353 aa overlap (58-393:20-361) 30 40 50 60 70 80 pF1KE1 TAARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVL--LIVAGNVLVIVAIAK : : . :.:.:. : . :. ::.::. XP_011 MNITNCTTEASMAIRPKTITEKMLICMTLVVITTLTTLLNLAVIMAIGT 10 20 30 40 90 100 110 120 130 140 pF1KE1 TPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTAS : .:. .: .: ::: .::....::.:.. .: ::. : :.::.: :::. : : : XP_011 TKKLHQPANYLICSLAVTDLLVAVLVMPLSIIYIVMDRWKLGYFLCEVWLSVDMTCCTCS 50 60 70 80 90 100 150 160 170 180 190 200 pF1KE1 IETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDE : ::::::::: :::. ..: : :: .. :::.:: ..:. :.. ::.. XP_011 ILHLCVIALDRYWAITNAIEYARKRTAKRAALMILTVWTISIFISMPPLF---WRSH--- 110 120 130 140 150 160 210 220 230 240 250 260 pF1KE1 ARRCYNDPKCCDFVTNRA-YAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERR :: :. : . ... :.: :.. .::.:: .. ..: :... :.. .: : : XP_011 -RRLSPPPSQCTIQHDHVIYTIYSTLGAFYIPLTLILILYYRIYHAAKSLYQKRGSS--R 170 180 190 200 210 220 270 280 290 300 310 pF1KE1 FLGGPARPPSPS-----------PSPVPAPAPPPGPPRPAAAAATAPLANG--RAGKRRP :.. . . : : . : . :. :. : . :.:. XP_011 HLSNRSTDSQNSFASCKLTQTFCVSDFSTSDPTTEFEKFHASIRIPPFDNDLDHPGERQ- 230 240 250 260 270 320 330 340 350 360 370 pF1KE1 SRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSA .. . ::.:: . ::.:.:.: : :::::. ... .. : ... :..::::.:: XP_011 -QISSTRERKAARILGLILGAFILSWLPFFIKELIVGLSIYTVSSEVADFLTWLGYVNSL 280 290 300 310 320 330 380 390 400 410 420 430 pF1KE1 FNPIIYCR-SPDFRKAFQRLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDD .::..: . ::. ::..:. : XP_011 INPLLYTSFNEDFKLAFKKLIRCREHT 340 350 360 >>NP_387512 (OMIM: 126451,181500,190300) D(3) dopamine r (367 aa) initn: 476 init1: 160 opt: 604 Z-score: 377.4 bits: 78.8 E(85289): 2.8e-14 Smith-Waterman score: 604; 33.8% identity (62.8% similar) in 349 aa overlap (59-393:30-367) 30 40 50 60 70 80 pF1KE1 AARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPR : ..: . ..: :: :: :: .:. : NP_387 MASLSQLSGHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERA 10 20 30 40 50 90 100 110 120 130 140 pF1KE1 LQTLTNLFIMSLASADLVMGLLVVPFGATI-VVWGRWEYGSFFCELWTSVDVLCVTASIE ::: :: ...::: :::... ::.:. . . :. : :... . :......::. :::: NP_387 LQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASIL 60 70 80 90 100 110 150 160 170 180 190 200 pF1KE1 TLCVIALDRYLAITSPFRYQSLLTRARARG---LVCTVWAISALVSFLPILMHWWRAESD .::.:..::: :.. : .:: .. : .. .::... :: :.:. . NP_387 NLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSC-PLLFGF------ 120 130 140 150 160 170 210 220 230 240 250 260 pF1KE1 EARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERR .:: :. ..: ..: :::::::.:. . ..:: :.. ... .: .. NP_387 ---NTTGDPTVCS-ISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQN 180 190 200 210 220 270 280 290 300 310 pF1KE1 FLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATA---PLANGRAGK-RRPSR----LVA . .:: :. . : :: . :: : . :.:. .: . :. NP_387 SQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLMP 230 240 250 260 270 280 320 330 340 350 360 370 pF1KE1 LREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHREL-VPDRLFVFFNWLGYANSAFNPI :::.:: . ..:..:.: .:::::::..:... . : .:. .::::.:::.::. NP_387 LREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPV 290 300 310 320 330 340 380 390 400 410 420 430 pF1KE1 IYCR-SPDFRKAFQRLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDDDDD :: . .::::: ..: : NP_387 IYTTFNIEFRKAFLKILSC 350 360 >>NP_001309139 (OMIM: 182134) 5-hydroxytryptamine recept (366 aa) initn: 589 init1: 289 opt: 571 Z-score: 357.9 bits: 75.2 E(85289): 3.4e-13 Smith-Waterman score: 571; 32.4% identity (61.9% similar) in 352 aa overlap (61-393:26-364) 40 50 60 70 80 90 pF1KE1 RLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQ ..: .. ..:. .. : :::.:: : .:. NP_001 MDFLNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLH 10 20 30 40 50 100 110 120 130 140 150 pF1KE1 TLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLC .: .: ::: .:.....::.::. . .: : .:. :..: :::. : : :: : NP_001 HPANYLICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLS 60 70 80 90 100 110 160 170 180 190 200 210 pF1KE1 VIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCY .:::::: :::. .: : .: .. :: ::...:. :.. :: .. .: NP_001 AIALDRYRAITDAVEYARKRTPKHAGIMITIVWIISVFISMPPLF---WRHQGT-SR--- 120 130 140 150 160 220 230 240 250 260 pF1KE1 NDPKCC---DFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQ-----KQVKKIDSCE : .: : ... : :. .::.:: .. ..: ...: :. .:...: . : NP_001 -DDECIIKHDHIVSTIY---STFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEE 170 180 190 200 210 220 270 280 290 300 310 pF1KE1 ---RRFL-GGPARPPSPSPSPV-----PAPAPPPGPPRPAAAAATAPLANGRAGKRRPSR . .: .: : : : : :. . .. . . . . .. .:. . NP_001 VNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQ--K 230 240 250 260 270 280 320 330 340 350 360 370 pF1KE1 LVALREQKALKTLGIIMGVFTLCWLPFFLAN-VVKAFHRELVPDRLFVFFNWLGYANSAF . . ::.:: :::.:.:.:..::::::. . ::.. . . ... :. :::: :: . NP_001 ISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLI 290 300 310 320 330 340 380 390 400 410 420 430 pF1KE1 NPIIYC-RSPDFRKAFQRLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDD ::.:: . ::.::::.:. : NP_001 NPLIYTIFNEDFKKAFQKLVRCRC 350 360 >>NP_001309137 (OMIM: 182134) 5-hydroxytryptamine recept (366 aa) initn: 589 init1: 289 opt: 571 Z-score: 357.9 bits: 75.2 E(85289): 3.4e-13 Smith-Waterman score: 571; 32.4% identity (61.9% similar) in 352 aa overlap (61-393:26-364) 40 50 60 70 80 90 pF1KE1 RLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQ ..: .. ..:. .. : :::.:: : .:. NP_001 MDFLNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLH 10 20 30 40 50 100 110 120 130 140 150 pF1KE1 TLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLC .: .: ::: .:.....::.::. . .: : .:. :..: :::. : : :: : NP_001 HPANYLICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLS 60 70 80 90 100 110 160 170 180 190 200 210 pF1KE1 VIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCY .:::::: :::. .: : .: .. :: ::...:. :.. :: .. .: NP_001 AIALDRYRAITDAVEYARKRTPKHAGIMITIVWIISVFISMPPLF---WRHQGT-SR--- 120 130 140 150 160 220 230 240 250 260 pF1KE1 NDPKCC---DFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQ-----KQVKKIDSCE : .: : ... : :. .::.:: .. ..: ...: :. .:...: . : NP_001 -DDECIIKHDHIVSTIY---STFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEE 170 180 190 200 210 220 270 280 290 300 310 pF1KE1 ---RRFL-GGPARPPSPSPSPV-----PAPAPPPGPPRPAAAAATAPLANGRAGKRRPSR . .: .: : : : : :. . .. . . . . .. .:. . NP_001 VNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQ--K 230 240 250 260 270 280 320 330 340 350 360 370 pF1KE1 LVALREQKALKTLGIIMGVFTLCWLPFFLAN-VVKAFHRELVPDRLFVFFNWLGYANSAF . . ::.:: :::.:.:.:..::::::. . ::.. . . ... :. :::: :: . NP_001 ISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLI 290 300 310 320 330 340 380 390 400 410 420 430 pF1KE1 NPIIYC-RSPDFRKAFQRLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDD ::.:: . ::.::::.:. : NP_001 NPLIYTIFNEDFKKAFQKLVRCRC 350 360 477 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 07:58:36 2016 done: Sun Nov 6 07:58:38 2016 Total Scan time: 11.210 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]