FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6379, 327 aa 1>>>pF1KE6379 327 - 327 aa - 327 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0617+/-0.000449; mu= 16.8024+/- 0.028 mean_var=59.9467+/-11.670, 0's: 0 Z-trim(108.8): 25 B-trim: 406 in 1/53 Lambda= 0.165650 statistics sampled from 16883 (16895) to 16883 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.562), E-opt: 0.2 (0.198), width: 16 Scan time: 3.780 The best scores are: opt bits E(85289) NP_004887 (OMIM: 605506) vacuolar protein sorting- ( 327) 2141 520.5 1.9e-147 NP_001305874 (OMIM: 605506) vacuolar protein sorti ( 310) 1802 439.5 4.3e-123 NP_001305873 (OMIM: 605506) vacuolar protein sorti ( 320) 1796 438.1 1.2e-122 NP_001030337 (OMIM: 605506) vacuolar protein sorti ( 251) 1582 386.9 2.4e-107 NP_443107 (OMIM: 610027) vacuolar protein sorting- ( 336) 1540 376.9 3.3e-104 NP_001305875 (OMIM: 605506) vacuolar protein sorti ( 216) 1404 344.3 1.4e-94 XP_011540867 (OMIM: 610027) PREDICTED: vacuolar pr ( 229) 892 221.9 9.8e-58 NP_001317951 (OMIM: 605298) Down syndrome critical ( 270) 165 48.2 2.3e-05 NP_001317947 (OMIM: 605298) Down syndrome critical ( 172) 126 38.8 0.0099 >>NP_004887 (OMIM: 605506) vacuolar protein sorting-asso (327 aa) initn: 2141 init1: 2141 opt: 2141 Z-score: 2768.3 bits: 520.5 E(85289): 1.9e-147 Smith-Waterman score: 2141; 100.0% identity (100.0% similar) in 327 aa overlap (1-327:1-327) 10 20 30 40 50 60 pF1KE6 MSFLGGFFGPICEIDIVLNDGETRKMAEMKTEDGKVEKHYLFYDGESVSGKVNLAFKQPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MSFLGGFFGPICEIDIVLNDGETRKMAEMKTEDGKVEKHYLFYDGESVSGKVNLAFKQPG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 KRLEHQGIRIEFVGQIELFNDKSNTHEFVNLVKELALPGELTQSRSYDFEFMQVEKPYES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 KRLEHQGIRIEFVGQIELFNDKSNTHEFVNLVKELALPGELTQSRSYDFEFMQVEKPYES 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 YIGANVRLRYFLKVTIVRRLTDLVKEYDLIVHQLATYPDVNNSIKMEVGIEDCLHIEFEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 YIGANVRLRYFLKVTIVRRLTDLVKEYDLIVHQLATYPDVNNSIKMEVGIEDCLHIEFEY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 NKSKYHLKDVIVGKIYFLLVRIKIQHMELQLIKKEITGIGPSTTTETETIAKYEIMDGAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 NKSKYHLKDVIVGKIYFLLVRIKIQHMELQLIKKEITGIGPSTTTETETIAKYEIMDGAP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 VKGESIPIRLFLAGYDPTPTMRDVNKKFSVRYFLNLVLVDEEDRRYFKQQEIILWRKAPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 VKGESIPIRLFLAGYDPTPTMRDVNKKFSVRYFLNLVLVDEEDRRYFKQQEIILWRKAPE 250 260 270 280 290 300 310 320 pF1KE6 KLRKQRTNFHQRFESPESQASAEQPEM ::::::::::::::::::::::::::: NP_004 KLRKQRTNFHQRFESPESQASAEQPEM 310 320 >>NP_001305874 (OMIM: 605506) vacuolar protein sorting-a (310 aa) initn: 1802 init1: 1802 opt: 1802 Z-score: 2330.8 bits: 439.5 E(85289): 4.3e-123 Smith-Waterman score: 1802; 100.0% identity (100.0% similar) in 277 aa overlap (51-327:34-310) 30 40 50 60 70 80 pF1KE6 GETRKMAEMKTEDGKVEKHYLFYDGESVSGKVNLAFKQPGKRLEHQGIRIEFVGQIELFN :::::::::::::::::::::::::::::: NP_001 NPFQERYSVEDLSTFGMCLCMVRYVYDAFYKVNLAFKQPGKRLEHQGIRIEFVGQIELFN 10 20 30 40 50 60 90 100 110 120 130 140 pF1KE6 DKSNTHEFVNLVKELALPGELTQSRSYDFEFMQVEKPYESYIGANVRLRYFLKVTIVRRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DKSNTHEFVNLVKELALPGELTQSRSYDFEFMQVEKPYESYIGANVRLRYFLKVTIVRRL 70 80 90 100 110 120 150 160 170 180 190 200 pF1KE6 TDLVKEYDLIVHQLATYPDVNNSIKMEVGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TDLVKEYDLIVHQLATYPDVNNSIKMEVGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLLV 130 140 150 160 170 180 210 220 230 240 250 260 pF1KE6 RIKIQHMELQLIKKEITGIGPSTTTETETIAKYEIMDGAPVKGESIPIRLFLAGYDPTPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RIKIQHMELQLIKKEITGIGPSTTTETETIAKYEIMDGAPVKGESIPIRLFLAGYDPTPT 190 200 210 220 230 240 270 280 290 300 310 320 pF1KE6 MRDVNKKFSVRYFLNLVLVDEEDRRYFKQQEIILWRKAPEKLRKQRTNFHQRFESPESQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MRDVNKKFSVRYFLNLVLVDEEDRRYFKQQEIILWRKAPEKLRKQRTNFHQRFESPESQA 250 260 270 280 290 300 pF1KE6 SAEQPEM ::::::: NP_001 SAEQPEM 310 >>NP_001305873 (OMIM: 605506) vacuolar protein sorting-a (320 aa) initn: 1796 init1: 1796 opt: 1796 Z-score: 2322.9 bits: 438.1 E(85289): 1.2e-122 Smith-Waterman score: 1796; 100.0% identity (100.0% similar) in 276 aa overlap (52-327:45-320) 30 40 50 60 70 80 pF1KE6 ETRKMAEMKTEDGKVEKHYLFYDGESVSGKVNLAFKQPGKRLEHQGIRIEFVGQIELFND :::::::::::::::::::::::::::::: NP_001 LSTFGMCLCMVRYVYDAFYKVSLFSPFLYPVNLAFKQPGKRLEHQGIRIEFVGQIELFND 20 30 40 50 60 70 90 100 110 120 130 140 pF1KE6 KSNTHEFVNLVKELALPGELTQSRSYDFEFMQVEKPYESYIGANVRLRYFLKVTIVRRLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KSNTHEFVNLVKELALPGELTQSRSYDFEFMQVEKPYESYIGANVRLRYFLKVTIVRRLT 80 90 100 110 120 130 150 160 170 180 190 200 pF1KE6 DLVKEYDLIVHQLATYPDVNNSIKMEVGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLLVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLVKEYDLIVHQLATYPDVNNSIKMEVGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLLVR 140 150 160 170 180 190 210 220 230 240 250 260 pF1KE6 IKIQHMELQLIKKEITGIGPSTTTETETIAKYEIMDGAPVKGESIPIRLFLAGYDPTPTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IKIQHMELQLIKKEITGIGPSTTTETETIAKYEIMDGAPVKGESIPIRLFLAGYDPTPTM 200 210 220 230 240 250 270 280 290 300 310 320 pF1KE6 RDVNKKFSVRYFLNLVLVDEEDRRYFKQQEIILWRKAPEKLRKQRTNFHQRFESPESQAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RDVNKKFSVRYFLNLVLVDEEDRRYFKQQEIILWRKAPEKLRKQRTNFHQRFESPESQAS 260 270 280 290 300 310 pF1KE6 AEQPEM :::::: NP_001 AEQPEM 320 >>NP_001030337 (OMIM: 605506) vacuolar protein sorting-a (251 aa) initn: 1582 init1: 1582 opt: 1582 Z-score: 2048.1 bits: 386.9 E(85289): 2.4e-107 Smith-Waterman score: 1582; 99.2% identity (100.0% similar) in 245 aa overlap (1-245:1-245) 10 20 30 40 50 60 pF1KE6 MSFLGGFFGPICEIDIVLNDGETRKMAEMKTEDGKVEKHYLFYDGESVSGKVNLAFKQPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSFLGGFFGPICEIDIVLNDGETRKMAEMKTEDGKVEKHYLFYDGESVSGKVNLAFKQPG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 KRLEHQGIRIEFVGQIELFNDKSNTHEFVNLVKELALPGELTQSRSYDFEFMQVEKPYES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KRLEHQGIRIEFVGQIELFNDKSNTHEFVNLVKELALPGELTQSRSYDFEFMQVEKPYES 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 YIGANVRLRYFLKVTIVRRLTDLVKEYDLIVHQLATYPDVNNSIKMEVGIEDCLHIEFEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YIGANVRLRYFLKVTIVRRLTDLVKEYDLIVHQLATYPDVNNSIKMEVGIEDCLHIEFEY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 NKSKYHLKDVIVGKIYFLLVRIKIQHMELQLIKKEITGIGPSTTTETETIAKYEIMDGAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NKSKYHLKDVIVGKIYFLLVRIKIQHMELQLIKKEITGIGPSTTTETETIAKYEIMDGAP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 VKGESIPIRLFLAGYDPTPTMRDVNKKFSVRYFLNLVLVDEEDRRYFKQQEIILWRKAPE :::.. NP_001 VKGDNFMEKSS 250 >>NP_443107 (OMIM: 610027) vacuolar protein sorting-asso (336 aa) initn: 1527 init1: 1504 opt: 1540 Z-score: 1991.9 bits: 376.9 E(85289): 3.3e-104 Smith-Waterman score: 1540; 69.8% identity (89.3% similar) in 328 aa overlap (1-325:1-326) 10 20 30 40 50 60 pF1KE6 MSFLGGFFGPICEIDIVLNDGETRKMAEMKTEDGKVEKHYLFYDGESVSGKVNLAFKQPG :::.: :: :..:.:::.:.:: :: :::::: ::..::::::.:::::.::.:.:. NP_443 MSFFG--FGQSVEVEILLNDAESRKRAEHKTEDGKKEKYFLFYDGETVSGKVSLALKNPN 10 20 30 40 50 70 80 90 100 110 120 pF1KE6 KRLEHQGIRIEFVGQIELFNDKSNTHEFVNLVKELALPGELTQSRSYDFEFMQVEKPYES ::::::::.:::.:::::. :..: ::::.:::.:: :::.:::...:::: .::::::: NP_443 KRLEHQGIKIEFIGQIELYYDRGNHHEFVSLVKDLARPGEITQSQAFDFEFTHVEKPYES 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE6 YIGANVRLRYFLKVTIVRRLTDLVKEYDLIVHQLATYPDVNNSIKMEVGIEDCLHIEFEY : : ::.:::::..:: :::.:.:::.:..:: :.:::..:.:::::::::::::::::: NP_443 YTGQNVKLRYFLRATISRRLNDVVKEMDIVVHTLSTYPELNSSIKMEVGIEDCLHIEFEY 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE6 NKSKYHLKDVIVGKIYFLLVRIKIQHMELQLIKKEITGIGPSTTTETETIAKYEIMDGAP ::::::::::::::::::::::::.:::...::.: :: ::.. :..:::::::::::: NP_443 NKSKYHLKDVIVGKIYFLLVRIKIKHMEIDIIKRETTGTGPNVYHENDTIAKYEIMDGAP 180 190 200 210 220 230 250 260 270 280 290 pF1KE6 VKGESIPIRLFLAGYDPTPTMRDVNKKFSVRYFLNLVLVDEEDRRYFKQQEIILWRKAP- :.:::::::::::::. ::::::.::::::::.:::::.:::.::::::::..::::. NP_443 VRGESIPIRLFLAGYELTPTMRDINKKFSVRYYLNLVLIDEEERRYFKQQEVVLWRKGDI 240 250 260 270 280 290 300 310 320 pF1KE6 --EKLRKQRTNFHQRFESPESQASAEQPEM ... .: . ::::. : . .. : NP_443 VRKSMSHQAAIASQRFEGTTSLGEVRTPSQLSDNNCRQ 300 310 320 330 >>NP_001305875 (OMIM: 605506) vacuolar protein sorting-a (216 aa) initn: 1404 init1: 1404 opt: 1404 Z-score: 1819.1 bits: 344.3 E(85289): 1.4e-94 Smith-Waterman score: 1404; 100.0% identity (100.0% similar) in 216 aa overlap (112-327:1-216) 90 100 110 120 130 140 pF1KE6 KSNTHEFVNLVKELALPGELTQSRSYDFEFMQVEKPYESYIGANVRLRYFLKVTIVRRLT :::::::::::::::::::::::::::::: NP_001 MQVEKPYESYIGANVRLRYFLKVTIVRRLT 10 20 30 150 160 170 180 190 200 pF1KE6 DLVKEYDLIVHQLATYPDVNNSIKMEVGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLLVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLVKEYDLIVHQLATYPDVNNSIKMEVGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLLVR 40 50 60 70 80 90 210 220 230 240 250 260 pF1KE6 IKIQHMELQLIKKEITGIGPSTTTETETIAKYEIMDGAPVKGESIPIRLFLAGYDPTPTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IKIQHMELQLIKKEITGIGPSTTTETETIAKYEIMDGAPVKGESIPIRLFLAGYDPTPTM 100 110 120 130 140 150 270 280 290 300 310 320 pF1KE6 RDVNKKFSVRYFLNLVLVDEEDRRYFKQQEIILWRKAPEKLRKQRTNFHQRFESPESQAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RDVNKKFSVRYFLNLVLVDEEDRRYFKQQEIILWRKAPEKLRKQRTNFHQRFESPESQAS 160 170 180 190 200 210 pF1KE6 AEQPEM :::::: NP_001 AEQPEM >>XP_011540867 (OMIM: 610027) PREDICTED: vacuolar protei (229 aa) initn: 894 init1: 873 opt: 892 Z-score: 1157.5 bits: 221.9 E(85289): 9.8e-58 Smith-Waterman score: 892; 63.0% identity (85.2% similar) in 216 aa overlap (1-214:1-213) 10 20 30 40 50 60 pF1KE6 MSFLGGFFGPICEIDIVLNDGETRKMAEMKTEDGKVEKHYLFYDGESVSGKVNLAFKQPG :::.: :: :..:.:::.:.:: :: :::::: ::..::::::.:::::.::.:.:. XP_011 MSFFG--FGQSVEVEILLNDAESRKRAEHKTEDGKKEKYFLFYDGETVSGKVSLALKNPN 10 20 30 40 50 70 80 90 100 110 120 pF1KE6 KRLEHQGIRIEFVGQIELFNDKSNTHEFVNLVKELALPGELTQSRSYDFEFMQVEKPYES ::::::::.:::.:::::. :..: ::::.:::.:: :::.:::...:::: .::::::: XP_011 KRLEHQGIKIEFIGQIELYYDRGNHHEFVSLVKDLARPGEITQSQAFDFEFTHVEKPYES 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE6 YIGANVRLRYFLKVTIVRRLTDLVKEYDLIVHQLATYPDVNNSIKMEVGIEDCLHIEFEY : : ::.:::::..:: :::.:.:::.:..:: :.:::..:.:::::::::::::::::: XP_011 YTGQNVKLRYFLRATISRRLNDVVKEMDIVVHTLSTYPELNSSIKMEVGIEDCLHIEFEY 120 130 140 150 160 170 190 200 210 220 230 pF1KE6 NKSKYHLKDVIVGKI--YFLLVRIKIQHMELQLIKKEITGIGPSTTTETETIAKYEIMDG :::.. ... : : .. .. :. :: :. XP_011 NKSNFSCFPLLLRTISEYHSIIMCSL-HLCLQKSKRRNQILAMICCFLPELK 180 190 200 210 220 240 250 260 270 280 290 pF1KE6 APVKGESIPIRLFLAGYDPTPTMRDVNKKFSVRYFLNLVLVDEEDRRYFKQQEIILWRKA >>NP_001317951 (OMIM: 605298) Down syndrome critical reg (270 aa) initn: 172 init1: 100 opt: 165 Z-score: 217.4 bits: 48.2 E(85289): 2.3e-05 Smith-Waterman score: 169; 21.5% identity (55.9% similar) in 270 aa overlap (33-283:6-256) 10 20 30 40 50 60 pF1KE6 FLGGFFGPICEIDIVLNDGETRKMAEMKTEDGKVEK-HYLFYDGESVSGKVNLAFKQPGK : :... . ... :: .:: : .. :. NP_001 MGTALDIKIKRANKVYHAGEVLSGVVVISSKDS-- 10 20 30 70 80 90 100 pF1KE6 RLEHQGIRIEF------------VGQIELFNDKSNTHEFVNLVKELALPGELTQSRS-YD ..:::. . . :: .: : .. . ...: . :.. ::.. .... NP_001 -VQHQGVSLTMEGTVNLQLSAKSVGVFEAFYNSVKPIQIINSTIEMVKPGKFPSGKTEIP 40 50 60 70 80 90 110 120 130 140 150 160 pF1KE6 FEF---MQVEKP-YESYIGANVRLRYFLKVTIVR-RLTDLVKEYDLIVHQLATYPDVNNS ::: .. .: ::.: :. :... . ..: . :. . :.. .. NP_001 FEFPLHLKGNKVLYETYHGV------FVNIQPQKGKFTP--SPVDFTIT-----PETLQN 100 110 120 130 170 180 190 200 210 220 pF1KE6 IKMEVGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLLVRIKIQHMELQLIKKEITGIGPST .: .. . : .. . :... . . ..:.. . :. .::::.. : : . . NP_001 VKERALLPKFL-LRGHLNSTNCVITQPLTGELVVESSEAAIRSVELQLVRVETCGCAEGY 140 150 160 170 180 190 230 240 250 260 270 280 pF1KE6 TTETETIAKYEIMDGAPVKGESIPIRLFLAGYDPTPTMRDVNKKFSVRYFLNLVLVDEED . .. : . .: :: .: :.:: . . ::.. .: :.:.. .:.:.. . : NP_001 ARDATEIQNIQIADGDVCRGLSVPIYMVFPRLFTCPTLETTN--FKVEFEVNIVVLLHPD 200 210 220 230 240 250 290 300 310 320 pF1KE6 RRYFKQQEIILWRKAPEKLRKQRTNFHQRFESPESQASAEQPEM NP_001 HLITENFPLKLCRI 260 270 >>NP_001317947 (OMIM: 605298) Down syndrome critical reg (172 aa) initn: 122 init1: 100 opt: 126 Z-score: 170.0 bits: 38.8 E(85289): 0.0099 Smith-Waterman score: 126; 22.2% identity (59.5% similar) in 126 aa overlap (158-283:36-158) 130 140 150 160 170 180 pF1KE6 LRYFLKVTIVRRLTDLVKEYDLIVHQLATYPDVNNSIKMEVGIEDCLHIEFEYNKSKYHL :.. ...: .. . : .. . :... . NP_001 DIKIKRANKVYHAGPQKGKFTPSPVDFTITPETLQNVKERALLPKFL-LRGHLNSTNCVI 10 20 30 40 50 60 190 200 210 220 230 240 pF1KE6 KDVIVGKIYFLLVRIKIQHMELQLIKKEITGIGPSTTTETETIAKYEIMDGAPVKGESIP . ..:.. . :. .::::.. : : . . . .. : . .: :: .: :.: NP_001 TQPLTGELVVESSEAAIRSVELQLVRVETCGCAEGYARDATEIQNIQIADGDVCRGLSVP 70 80 90 100 110 120 250 260 270 280 290 300 pF1KE6 IRLFLAGYDPTPTMRDVNKKFSVRYFLNLVLVDEEDRRYFKQQEIILWRKAPEKLRKQRT : . . ::.. .: :.:.. .:.:.. . : NP_001 IYMVFPRLFTCPTLETTN--FKVEFEVNIVVLLHPDHLITENFPLKLCRI 130 140 150 160 170 310 320 pF1KE6 NFHQRFESPESQASAEQPEM 327 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 12:44:16 2016 done: Tue Nov 8 12:44:17 2016 Total Scan time: 3.780 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]