FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1748, 251 aa 1>>>pF1KE1748 251 - 251 aa - 251 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2423+/-0.000366; mu= 14.6183+/- 0.023 mean_var=63.2527+/-12.659, 0's: 0 Z-trim(113.2): 21 B-trim: 0 in 0/50 Lambda= 0.161263 statistics sampled from 22346 (22366) to 22346 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.648), E-opt: 0.2 (0.262), width: 16 Scan time: 6.430 The best scores are: opt bits E(85289) NP_005109 (OMIM: 604052) tumor necrosis factor lig ( 251) 1687 401.1 1e-111 NP_001191273 (OMIM: 604052) tumor necrosis factor ( 192) 1117 268.4 6.7e-72 NP_000585 (OMIM: 157300,191160,600807,611162) tumo ( 233) 231 62.3 8.8e-10 NP_001153212 (OMIM: 153440,607507,608446,610988) l ( 205) 227 61.3 1.5e-09 XP_011512917 (OMIM: 153440,607507,608446,610988) P ( 205) 227 61.3 1.5e-09 XP_011512918 (OMIM: 153440,607507,608446,610988) P ( 205) 227 61.3 1.5e-09 XP_011512920 (OMIM: 153440,607507,608446,610988) P ( 205) 227 61.3 1.5e-09 XP_011512919 (OMIM: 153440,607507,608446,610988) P ( 205) 227 61.3 1.5e-09 NP_000586 (OMIM: 153440,607507,608446,610988) lymp ( 205) 227 61.3 1.5e-09 NP_742011 (OMIM: 604520) tumor necrosis factor lig ( 204) 222 60.2 3.4e-09 NP_003798 (OMIM: 604520) tumor necrosis factor lig ( 240) 222 60.2 3.9e-09 XP_016882906 (OMIM: 604520) PREDICTED: tumor necro ( 240) 222 60.2 3.9e-09 NP_003801 (OMIM: 603598) tumor necrosis factor lig ( 281) 217 59.1 9.9e-09 XP_011533582 (OMIM: 259710,602642) PREDICTED: tumo ( 244) 206 56.5 5.2e-08 NP_143026 (OMIM: 259710,602642) tumor necrosis fac ( 244) 206 56.5 5.2e-08 XP_016876292 (OMIM: 259710,602642) PREDICTED: tumo ( 244) 206 56.5 5.2e-08 XP_016876291 (OMIM: 259710,602642) PREDICTED: tumo ( 263) 206 56.5 5.5e-08 NP_003692 (OMIM: 259710,602642) tumor necrosis fac ( 317) 206 56.5 6.5e-08 NP_000630 (OMIM: 134638,211980,601859) tumor necro ( 281) 173 48.8 1.2e-05 NP_002332 (OMIM: 600978) lymphotoxin-beta isoform ( 244) 166 47.2 3.3e-05 >>NP_005109 (OMIM: 604052) tumor necrosis factor ligand (251 aa) initn: 1687 init1: 1687 opt: 1687 Z-score: 2126.8 bits: 401.1 E(85289): 1e-111 Smith-Waterman score: 1687; 100.0% identity (100.0% similar) in 251 aa overlap (1-251:1-251) 10 20 30 40 50 60 pF1KE1 MAEDLGLSFGETASVEMLPEHGSCRPKARSSSARWALTCCLVLLPFLAGLTTYLLVSQLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MAEDLGLSFGETASVEMLPEHGSCRPKARSSSARWALTCCLVLLPFLAGLTTYLLVSQLR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 AQGEACVQFQALKGQEFAPSHQQVYAPLRADGDKPRAHLTVVRQTPTQHFKNQFPALHWE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 AQGEACVQFQALKGQEFAPSHQQVYAPLRADGDKPRAHLTVVRQTPTQHFKNQFPALHWE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 HELGLAFTKNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPDSITVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 HELGLAFTKNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPDSITVV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 ITKVTDSYPEPTQLLMGTKSVCEVGSNWFQPIYLGAMFSLQEGDKLMVNVSDISLVDYTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 ITKVTDSYPEPTQLLMGTKSVCEVGSNWFQPIYLGAMFSLQEGDKLMVNVSDISLVDYTK 190 200 210 220 230 240 250 pF1KE1 EDKTFFGAFLL ::::::::::: NP_005 EDKTFFGAFLL 250 >>NP_001191273 (OMIM: 604052) tumor necrosis factor liga (192 aa) initn: 1117 init1: 1117 opt: 1117 Z-score: 1411.9 bits: 268.4 E(85289): 6.7e-72 Smith-Waterman score: 1117; 100.0% identity (100.0% similar) in 166 aa overlap (86-251:27-192) 60 70 80 90 100 110 pF1KE1 VSQLRAQGEACVQFQALKGQEFAPSHQQVYAPLRADGDKPRAHLTVVRQTPTQHFKNQFP :::::::::::::::::::::::::::::: NP_001 MQLTKGRLHFSHPLSHTKHISPFVTDAPLRADGDKPRAHLTVVRQTPTQHFKNQFP 10 20 30 40 50 120 130 140 150 160 170 pF1KE1 ALHWEHELGLAFTKNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALHWEHELGLAFTKNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPD 60 70 80 90 100 110 180 190 200 210 220 230 pF1KE1 SITVVITKVTDSYPEPTQLLMGTKSVCEVGSNWFQPIYLGAMFSLQEGDKLMVNVSDISL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SITVVITKVTDSYPEPTQLLMGTKSVCEVGSNWFQPIYLGAMFSLQEGDKLMVNVSDISL 120 130 140 150 160 170 240 250 pF1KE1 VDYTKEDKTFFGAFLL :::::::::::::::: NP_001 VDYTKEDKTFFGAFLL 180 190 >>NP_000585 (OMIM: 157300,191160,600807,611162) tumor ne (233 aa) initn: 211 init1: 110 opt: 231 Z-score: 296.6 bits: 62.3 E(85289): 8.8e-10 Smith-Waterman score: 270; 28.0% identity (58.1% similar) in 236 aa overlap (26-251:18-233) 10 20 30 40 50 pF1KE1 MAEDLGLSFGETASVEMLPEHGSCRPKARSSSARWALTCC-LVLLPFL--AGLTTYLLVS :: .... . . : : :. :: :: :: . . NP_000 MSTESMIRDVELAEEALPK-KTGGPQGSRRCLFLSLFSFLIVAGATTLFCLL 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 QLRAQGEACVQFQALKGQEFAPSHQQVYAPLRADGDKPRAHLTVVRQTPTQHFKNQFPAL .. . : .: . ..: : : . :. .::: ::... :. : : NP_000 HFGVIGPQREEFPR-DLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQ--------L 60 70 80 90 100 120 130 140 150 160 170 pF1KE1 HWEHELGLAFTKNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPDSI .: .. . :. : .. .. :..: : :.::::: :.:. : :. . NP_000 QWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQ----------GCPSTHVLL 110 120 130 140 150 180 190 200 210 220 230 pF1KE1 TVVITKVTDSYPEPTQLLMGTKSVCEV----GSN---WFQPIYLGAMFSLQEGDKLMVNV : .:.... :: ..:: . :: :. :.. :..:::::..:.:..::.: ... NP_000 THTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEI 160 170 180 190 200 210 240 250 pF1KE1 SDISLVDYTKEDKTFFGAFLL . . .:... ...:: . : NP_000 NRPDYLDFAESGQVYFGIIAL 220 230 >>NP_001153212 (OMIM: 153440,607507,608446,610988) lymph (205 aa) initn: 228 init1: 122 opt: 227 Z-score: 292.4 bits: 61.3 E(85289): 1.5e-09 Smith-Waterman score: 228; 28.6% identity (53.9% similar) in 217 aa overlap (42-251:7-205) 20 30 40 50 60 70 pF1KE1 TASVEMLPEHGSCRPKARSSSARWALTCCLVLLPFLAGLTTYLLVSQLRAQGEACVQFQA ..:: . : : .::. : .: . NP_001 MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQ--G 10 20 30 80 90 100 110 120 pF1KE1 LKGQEFAPSHQQVYAPLRADGDKPRAHLTVVRQTPTQHF---KNQFPALHWEHELGLAFT : : ..:: :. ..:. ::. :. :. .. .: :. . :: NP_001 LPGVGLTPSAAQTAR------QHPKMHLAHSTLKPAAHLIGDPSKQNSLLWRANTDRAFL 40 50 60 70 80 130 140 150 160 170 180 pF1KE1 KNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPDSITVVITKV---T .. .. .:. ::.: :: ::.::::.: : .: :. .: . .: . NP_001 QDGFSLSNNSLLVPTSGIYFVYSQVVFSG---------KAYSPKATSSPLYLAHEVQLFS 90 100 110 120 130 190 200 210 220 230 240 pF1KE1 DSYPEPTQLLMGTKSVCE-VGSNWFQPIYLGAMFSLQEGDKLMVNVSDISLVDYTKEDKT ..:: . :: . : : . :.. .: :: :.: .::.: .... : . . . . NP_001 SQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQLSTHTDGIPHL-VLSPSTV 140 150 160 170 180 190 250 pF1KE1 FFGAFLL ::::: : NP_001 FFGAFAL 200 >>XP_011512917 (OMIM: 153440,607507,608446,610988) PREDI (205 aa) initn: 228 init1: 122 opt: 227 Z-score: 292.4 bits: 61.3 E(85289): 1.5e-09 Smith-Waterman score: 228; 28.6% identity (53.9% similar) in 217 aa overlap (42-251:7-205) 20 30 40 50 60 70 pF1KE1 TASVEMLPEHGSCRPKARSSSARWALTCCLVLLPFLAGLTTYLLVSQLRAQGEACVQFQA ..:: . : : .::. : .: . XP_011 MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQ--G 10 20 30 80 90 100 110 120 pF1KE1 LKGQEFAPSHQQVYAPLRADGDKPRAHLTVVRQTPTQHF---KNQFPALHWEHELGLAFT : : ..:: :. ..:. ::. :. :. .. .: :. . :: XP_011 LPGVGLTPSAAQTAR------QHPKMHLAHSTLKPAAHLIGDPSKQNSLLWRANTDRAFL 40 50 60 70 80 130 140 150 160 170 180 pF1KE1 KNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPDSITVVITKV---T .. .. .:. ::.: :: ::.::::.: : .: :. .: . .: . XP_011 QDGFSLSNNSLLVPTSGIYFVYSQVVFSG---------KAYSPKATSSPLYLAHEVQLFS 90 100 110 120 130 190 200 210 220 230 240 pF1KE1 DSYPEPTQLLMGTKSVCE-VGSNWFQPIYLGAMFSLQEGDKLMVNVSDISLVDYTKEDKT ..:: . :: . : : . :.. .: :: :.: .::.: .... : . . . . XP_011 SQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQLSTHTDGIPHL-VLSPSTV 140 150 160 170 180 190 250 pF1KE1 FFGAFLL ::::: : XP_011 FFGAFAL 200 >>XP_011512918 (OMIM: 153440,607507,608446,610988) PREDI (205 aa) initn: 228 init1: 122 opt: 227 Z-score: 292.4 bits: 61.3 E(85289): 1.5e-09 Smith-Waterman score: 228; 28.6% identity (53.9% similar) in 217 aa overlap (42-251:7-205) 20 30 40 50 60 70 pF1KE1 TASVEMLPEHGSCRPKARSSSARWALTCCLVLLPFLAGLTTYLLVSQLRAQGEACVQFQA ..:: . : : .::. : .: . XP_011 MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQ--G 10 20 30 80 90 100 110 120 pF1KE1 LKGQEFAPSHQQVYAPLRADGDKPRAHLTVVRQTPTQHF---KNQFPALHWEHELGLAFT : : ..:: :. ..:. ::. :. :. .. .: :. . :: XP_011 LPGVGLTPSAAQTAR------QHPKMHLAHSTLKPAAHLIGDPSKQNSLLWRANTDRAFL 40 50 60 70 80 130 140 150 160 170 180 pF1KE1 KNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPDSITVVITKV---T .. .. .:. ::.: :: ::.::::.: : .: :. .: . .: . XP_011 QDGFSLSNNSLLVPTSGIYFVYSQVVFSG---------KAYSPKATSSPLYLAHEVQLFS 90 100 110 120 130 190 200 210 220 230 240 pF1KE1 DSYPEPTQLLMGTKSVCE-VGSNWFQPIYLGAMFSLQEGDKLMVNVSDISLVDYTKEDKT ..:: . :: . : : . :.. .: :: :.: .::.: .... : . . . . XP_011 SQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQLSTHTDGIPHL-VLSPSTV 140 150 160 170 180 190 250 pF1KE1 FFGAFLL ::::: : XP_011 FFGAFAL 200 >>XP_011512920 (OMIM: 153440,607507,608446,610988) PREDI (205 aa) initn: 228 init1: 122 opt: 227 Z-score: 292.4 bits: 61.3 E(85289): 1.5e-09 Smith-Waterman score: 228; 28.6% identity (53.9% similar) in 217 aa overlap (42-251:7-205) 20 30 40 50 60 70 pF1KE1 TASVEMLPEHGSCRPKARSSSARWALTCCLVLLPFLAGLTTYLLVSQLRAQGEACVQFQA ..:: . : : .::. : .: . XP_011 MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQ--G 10 20 30 80 90 100 110 120 pF1KE1 LKGQEFAPSHQQVYAPLRADGDKPRAHLTVVRQTPTQHF---KNQFPALHWEHELGLAFT : : ..:: :. ..:. ::. :. :. .. .: :. . :: XP_011 LPGVGLTPSAAQTAR------QHPKMHLAHSTLKPAAHLIGDPSKQNSLLWRANTDRAFL 40 50 60 70 80 130 140 150 160 170 180 pF1KE1 KNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPDSITVVITKV---T .. .. .:. ::.: :: ::.::::.: : .: :. .: . .: . XP_011 QDGFSLSNNSLLVPTSGIYFVYSQVVFSG---------KAYSPKATSSPLYLAHEVQLFS 90 100 110 120 130 190 200 210 220 230 240 pF1KE1 DSYPEPTQLLMGTKSVCE-VGSNWFQPIYLGAMFSLQEGDKLMVNVSDISLVDYTKEDKT ..:: . :: . : : . :.. .: :: :.: .::.: .... : . . . . XP_011 SQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQLSTHTDGIPHL-VLSPSTV 140 150 160 170 180 190 250 pF1KE1 FFGAFLL ::::: : XP_011 FFGAFAL 200 >>XP_011512919 (OMIM: 153440,607507,608446,610988) PREDI (205 aa) initn: 228 init1: 122 opt: 227 Z-score: 292.4 bits: 61.3 E(85289): 1.5e-09 Smith-Waterman score: 228; 28.6% identity (53.9% similar) in 217 aa overlap (42-251:7-205) 20 30 40 50 60 70 pF1KE1 TASVEMLPEHGSCRPKARSSSARWALTCCLVLLPFLAGLTTYLLVSQLRAQGEACVQFQA ..:: . : : .::. : .: . XP_011 MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQ--G 10 20 30 80 90 100 110 120 pF1KE1 LKGQEFAPSHQQVYAPLRADGDKPRAHLTVVRQTPTQHF---KNQFPALHWEHELGLAFT : : ..:: :. ..:. ::. :. :. .. .: :. . :: XP_011 LPGVGLTPSAAQTAR------QHPKMHLAHSTLKPAAHLIGDPSKQNSLLWRANTDRAFL 40 50 60 70 80 130 140 150 160 170 180 pF1KE1 KNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPDSITVVITKV---T .. .. .:. ::.: :: ::.::::.: : .: :. .: . .: . XP_011 QDGFSLSNNSLLVPTSGIYFVYSQVVFSG---------KAYSPKATSSPLYLAHEVQLFS 90 100 110 120 130 190 200 210 220 230 240 pF1KE1 DSYPEPTQLLMGTKSVCE-VGSNWFQPIYLGAMFSLQEGDKLMVNVSDISLVDYTKEDKT ..:: . :: . : : . :.. .: :: :.: .::.: .... : . . . . XP_011 SQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQLSTHTDGIPHL-VLSPSTV 140 150 160 170 180 190 250 pF1KE1 FFGAFLL ::::: : XP_011 FFGAFAL 200 >>NP_000586 (OMIM: 153440,607507,608446,610988) lymphoto (205 aa) initn: 228 init1: 122 opt: 227 Z-score: 292.4 bits: 61.3 E(85289): 1.5e-09 Smith-Waterman score: 228; 28.6% identity (53.9% similar) in 217 aa overlap (42-251:7-205) 20 30 40 50 60 70 pF1KE1 TASVEMLPEHGSCRPKARSSSARWALTCCLVLLPFLAGLTTYLLVSQLRAQGEACVQFQA ..:: . : : .::. : .: . NP_000 MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQ--G 10 20 30 80 90 100 110 120 pF1KE1 LKGQEFAPSHQQVYAPLRADGDKPRAHLTVVRQTPTQHF---KNQFPALHWEHELGLAFT : : ..:: :. ..:. ::. :. :. .. .: :. . :: NP_000 LPGVGLTPSAAQTAR------QHPKMHLAHSTLKPAAHLIGDPSKQNSLLWRANTDRAFL 40 50 60 70 80 130 140 150 160 170 180 pF1KE1 KNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPDSITVVITKV---T .. .. .:. ::.: :: ::.::::.: : .: :. .: . .: . NP_000 QDGFSLSNNSLLVPTSGIYFVYSQVVFSG---------KAYSPKATSSPLYLAHEVQLFS 90 100 110 120 130 190 200 210 220 230 240 pF1KE1 DSYPEPTQLLMGTKSVCE-VGSNWFQPIYLGAMFSLQEGDKLMVNVSDISLVDYTKEDKT ..:: . :: . : : . :.. .: :: :.: .::.: .... : . . . . NP_000 SQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQLSTHTDGIPHL-VLSPSTV 140 150 160 170 180 190 250 pF1KE1 FFGAFLL ::::: : NP_000 FFGAFAL 200 >>NP_742011 (OMIM: 604520) tumor necrosis factor ligand (204 aa) initn: 192 init1: 88 opt: 222 Z-score: 286.1 bits: 60.2 E(85289): 3.4e-09 Smith-Waterman score: 238; 31.3% identity (57.5% similar) in 179 aa overlap (78-251:41-204) 50 60 70 80 90 100 pF1KE1 AGLTTYLLVSQLRAQGEACVQFQALKGQEFAPSHQQVYAPLRADGDKPRAHLTVVRQTPT : : .:. :. .: :::: . .. : NP_742 FVVDGQTDIPFTRLGRSHRRQSCSVARDGPAGSWEQLIQERRSHEVNPAAHLTGANSSLT 20 30 40 50 60 70 110 120 130 140 150 160 pF1KE1 QHFKNQFPALHWEHELGLAFTKNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQ . : : :: .::::: .. ..: . :.. ..: :.:::.: . :. NP_742 G---SGGPLL-WETQLGLAFLRG-LSYHDGALVVTKAGYYYIYSKVQLGGV--------- 80 90 100 110 170 180 190 200 210 220 pF1KE1 AGRP-NKPDSITVVITKVTDSYPEPTQLLMGTKSVCEVGSN----WFQPIYLGAMFSLQE : : . ..:: . : : ::: .::.. .: : ... :.. .::.. :. NP_742 -GCPLGLASTITHGLYKRTPRYPEELELLVSQQSPCGRATSSSRVWWDSSFLGGVVHLEA 120 130 140 150 160 170 230 240 250 pF1KE1 GDKLMVNVSDISLVDYTKEDKTFFGAFLL :.:..: : : :: ...::::.. NP_742 GEKVVVRVLDERLVRLRDGTRSYFGAFMV 180 190 200 251 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 15:43:22 2016 done: Sun Nov 6 15:43:23 2016 Total Scan time: 6.430 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]