FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5237, 251 aa 1>>>pF1KE5237 251 - 251 aa - 251 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.7393+/-0.000386; mu= 17.6974+/- 0.024 mean_var=61.6225+/-13.309, 0's: 0 Z-trim(113.1): 24 B-trim: 1044 in 1/49 Lambda= 0.163382 statistics sampled from 22311 (22335) to 22311 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.634), E-opt: 0.2 (0.262), width: 16 Scan time: 4.270 The best scores are: opt bits E(85289) NP_077271 (OMIM: 608813) derlin-1 isoform a [Homo ( 251) 1774 426.5 2.2e-119 NP_001128143 (OMIM: 608813) derlin-1 isoform b [Ho ( 231) 1209 293.3 2.5e-79 XP_006716720 (OMIM: 608813) PREDICTED: derlin-1 is ( 151) 1075 261.6 5.8e-70 NP_001317530 (OMIM: 608813) derlin-1 isoform c [Ho ( 151) 1075 261.6 5.8e-70 XP_011528808 (OMIM: 610305) PREDICTED: derlin-3 is ( 233) 502 126.7 3.7e-29 NP_940842 (OMIM: 610305) derlin-3 isoform 3 [Homo ( 205) 493 124.5 1.5e-28 NP_001002862 (OMIM: 610305) derlin-3 isoform 2 [Ho ( 235) 493 124.5 1.6e-28 NP_001129223 (OMIM: 610305) derlin-3 isoform 1 [Ho ( 239) 493 124.6 1.6e-28 NP_057125 (OMIM: 610304) derlin-2 isoform a [Homo ( 239) 487 123.1 4.4e-28 XP_011528807 (OMIM: 610305) PREDICTED: derlin-3 is ( 234) 484 122.4 7e-28 NP_001291706 (OMIM: 610304) derlin-2 isoform b [Ho ( 238) 478 121.0 1.9e-27 XP_016884570 (OMIM: 610305) PREDICTED: derlin-3 is ( 249) 401 102.9 5.7e-22 XP_016884571 (OMIM: 610305) PREDICTED: derlin-3 is ( 165) 341 88.6 7.5e-18 XP_016884567 (OMIM: 610305) PREDICTED: derlin-3 is ( 299) 265 70.9 2.9e-12 XP_016884568 (OMIM: 610305) PREDICTED: derlin-3 is ( 298) 256 68.8 1.3e-11 XP_016884569 (OMIM: 610305) PREDICTED: derlin-3 is ( 279) 184 51.8 1.6e-06 >>NP_077271 (OMIM: 608813) derlin-1 isoform a [Homo sapi (251 aa) initn: 1774 init1: 1774 opt: 1774 Z-score: 2264.4 bits: 426.5 E(85289): 2.2e-119 Smith-Waterman score: 1774; 100.0% identity (100.0% similar) in 251 aa overlap (1-251:1-251) 10 20 30 40 50 60 pF1KE5 MSDIGDWFRSIPAITRYWFAATVAVPLVGKLGLISPAYLFLWPEAFLYRFQIWRPITATF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_077 MSDIGDWFRSIPAITRYWFAATVAVPLVGKLGLISPAYLFLWPEAFLYRFQIWRPITATF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 YFPVGPGTGFLYLVNLYFLYQYSTRLETGAFDGRPADYLFMLLFNWICIVITGLAMDMQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_077 YFPVGPGTGFLYLVNLYFLYQYSTRLETGAFDGRPADYLFMLLFNWICIVITGLAMDMQL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 LMIPLIMSVLYVWAQLNRDMIVSFWFGTRFKACYLPWVILGFNYIIGGSVINELIGNLVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_077 LMIPLIMSVLYVWAQLNRDMIVSFWFGTRFKACYLPWVILGFNYIIGGSVINELIGNLVG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 HLYFFLMFRYPMDLGGRNFLSTPQFLYRWLPSRRGGVSGFGVPPASMRRAADQNGGGGRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_077 HLYFFLMFRYPMDLGGRNFLSTPQFLYRWLPSRRGGVSGFGVPPASMRRAADQNGGGGRH 190 200 210 220 230 240 250 pF1KE5 NWGQGFRLGDQ ::::::::::: NP_077 NWGQGFRLGDQ 250 >>NP_001128143 (OMIM: 608813) derlin-1 isoform b [Homo s (231 aa) initn: 1208 init1: 1208 opt: 1209 Z-score: 1545.2 bits: 293.3 E(85289): 2.5e-79 Smith-Waterman score: 1592; 92.0% identity (92.0% similar) in 251 aa overlap (1-251:1-231) 10 20 30 40 50 60 pF1KE5 MSDIGDWFRSIPAITRYWFAATVAVPLVGKLGLISPAYLFLWPEAFLYRFQIWRPITATF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSDIGDWFRSIPAITRYWFAATVAVPLVGKLGLISPAYLFLWPEAFLYRFQIWRPITATF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 YFPVGPGTGFLYLVNLYFLYQYSTRLETGAFDGRPADYLFMLLFNWICIVITGLAMDMQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YFPVGPGTGFLYLVNLYFLYQYSTRLETGAFDGRPADYLFMLLFNWICIVITGLAMDMQL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 LMIPLIMSVLYVWAQLNRDMIVSFWFGTRFKACYLPWVILGFNYIIGGSVINELIGNLVG ::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LMIPLIMSVLYVWAQLNRDMIVSFWFGTRFKACYLPWVILGFNYIIGGS----------- 130 140 150 160 190 200 210 220 230 240 pF1KE5 HLYFFLMFRYPMDLGGRNFLSTPQFLYRWLPSRRGGVSGFGVPPASMRRAADQNGGGGRH ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ---------YPMDLGGRNFLSTPQFLYRWLPSRRGGVSGFGVPPASMRRAADQNGGGGRH 170 180 190 200 210 220 250 pF1KE5 NWGQGFRLGDQ ::::::::::: NP_001 NWGQGFRLGDQ 230 >>XP_006716720 (OMIM: 608813) PREDICTED: derlin-1 isofor (151 aa) initn: 1075 init1: 1075 opt: 1075 Z-score: 1377.0 bits: 261.6 E(85289): 5.8e-70 Smith-Waterman score: 1075; 100.0% identity (100.0% similar) in 151 aa overlap (101-251:1-151) 80 90 100 110 120 130 pF1KE5 LYLVNLYFLYQYSTRLETGAFDGRPADYLFMLLFNWICIVITGLAMDMQLLMIPLIMSVL :::::::::::::::::::::::::::::: XP_006 MLLFNWICIVITGLAMDMQLLMIPLIMSVL 10 20 30 140 150 160 170 180 190 pF1KE5 YVWAQLNRDMIVSFWFGTRFKACYLPWVILGFNYIIGGSVINELIGNLVGHLYFFLMFRY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YVWAQLNRDMIVSFWFGTRFKACYLPWVILGFNYIIGGSVINELIGNLVGHLYFFLMFRY 40 50 60 70 80 90 200 210 220 230 240 250 pF1KE5 PMDLGGRNFLSTPQFLYRWLPSRRGGVSGFGVPPASMRRAADQNGGGGRHNWGQGFRLGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PMDLGGRNFLSTPQFLYRWLPSRRGGVSGFGVPPASMRRAADQNGGGGRHNWGQGFRLGD 100 110 120 130 140 150 pF1KE5 Q : XP_006 Q >>NP_001317530 (OMIM: 608813) derlin-1 isoform c [Homo s (151 aa) initn: 1075 init1: 1075 opt: 1075 Z-score: 1377.0 bits: 261.6 E(85289): 5.8e-70 Smith-Waterman score: 1075; 100.0% identity (100.0% similar) in 151 aa overlap (101-251:1-151) 80 90 100 110 120 130 pF1KE5 LYLVNLYFLYQYSTRLETGAFDGRPADYLFMLLFNWICIVITGLAMDMQLLMIPLIMSVL :::::::::::::::::::::::::::::: NP_001 MLLFNWICIVITGLAMDMQLLMIPLIMSVL 10 20 30 140 150 160 170 180 190 pF1KE5 YVWAQLNRDMIVSFWFGTRFKACYLPWVILGFNYIIGGSVINELIGNLVGHLYFFLMFRY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YVWAQLNRDMIVSFWFGTRFKACYLPWVILGFNYIIGGSVINELIGNLVGHLYFFLMFRY 40 50 60 70 80 90 200 210 220 230 240 250 pF1KE5 PMDLGGRNFLSTPQFLYRWLPSRRGGVSGFGVPPASMRRAADQNGGGGRHNWGQGFRLGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PMDLGGRNFLSTPQFLYRWLPSRRGGVSGFGVPPASMRRAADQNGGGGRHNWGQGFRLGD 100 110 120 130 140 150 pF1KE5 Q : NP_001 Q >>XP_011528808 (OMIM: 610305) PREDICTED: derlin-3 isofor (233 aa) initn: 479 init1: 365 opt: 502 Z-score: 644.5 bits: 126.7 E(85289): 3.7e-29 Smith-Waterman score: 502; 35.8% identity (66.5% similar) in 215 aa overlap (8-219:10-221) 10 20 30 40 50 pF1KE5 MSDIGDWFRSIPAITRYWFAATVAVPLVGKLGLISPAYLFLWPEAFLYRFQIWRPITA : ..::.:: . :: : . . .: :.:: :.. :. . .::.:: .: XP_011 MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE5 TFYFPVGPGTGFLYLVNLYFLYQYSTRLETGAFDGRPADYLFMLLFNWICIVITGLAMDM ..: :: :: .. :. :...: :: :.: :: ::..::.::. . ... :: .. XP_011 FLFF--GP-LGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSL 70 80 90 100 110 120 130 140 150 160 170 pF1KE5 QLLMIPLIMSVLYVWAQLNRDMIVSFWFGTRFKACYLPWVILGFNYIIGGSVINELIGNL .: :. ..:::.. . . :.:. :.: .:::...::. ..:.:.. .:.: XP_011 FFLGQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGIA 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE5 VGHLYFFLMFRYPMDLGGRNFLSTPQFLY---RWLPSRRGGVSGFGVPPASMRRAADQNG :::.:.:: .: . ::. .:.:: :: . : : : .: XP_011 VGHIYYFLEDVFPNQPGGKRLLQTPGFLLATAQQCPHRTGPSAGDFRAARPQLAVA 180 190 200 210 220 230 240 250 pF1KE5 GGGRHNWGQGFRLGDQ >>NP_940842 (OMIM: 610305) derlin-3 isoform 3 [Homo sapi (205 aa) initn: 479 init1: 365 opt: 493 Z-score: 633.8 bits: 124.5 E(85289): 1.5e-28 Smith-Waterman score: 493; 36.7% identity (68.8% similar) in 199 aa overlap (8-206:10-205) 10 20 30 40 50 pF1KE5 MSDIGDWFRSIPAITRYWFAATVAVPLVGKLGLISPAYLFLWPEAFLYRFQIWRPITA : ..::.:: . :: : . . .: :.:: :.. :. . .::.:: .: NP_940 MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE5 TFYFPVGPGTGFLYLVNLYFLYQYSTRLETGAFDGRPADYLFMLLFNWICIVITGLAMDM ..: :: :: .. :. :...: :: :.: :: ::..::.::. . ... :: .. NP_940 FLFF--GP-LGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSL 70 80 90 100 110 120 130 140 150 160 170 pF1KE5 QLLMIPLIMSVLYVWAQLNRDMIVSFWFGTRFKACYLPWVILGFNYIIGGSVINELIGNL .: :. ..:::.. . . :.:. :.: .:::...::. ..:.:.. .:.: NP_940 FFLGQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGIA 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE5 VGHLYFFLMFRYPMDLGGRNFLSTPQFLYRWLPSRRGGVSGFGVPPASMRRAADQNGGGG :::.:.:: .: . ::. .:.:: :: NP_940 VGHIYYFLEDVFPNQPGGKRLLQTPGFL 180 190 200 >>NP_001002862 (OMIM: 610305) derlin-3 isoform 2 [Homo s (235 aa) initn: 479 init1: 365 opt: 493 Z-score: 633.0 bits: 124.5 E(85289): 1.6e-28 Smith-Waterman score: 493; 36.7% identity (68.8% similar) in 199 aa overlap (8-206:10-205) 10 20 30 40 50 pF1KE5 MSDIGDWFRSIPAITRYWFAATVAVPLVGKLGLISPAYLFLWPEAFLYRFQIWRPITA : ..::.:: . :: : . . .: :.:: :.. :. . .::.:: .: NP_001 MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE5 TFYFPVGPGTGFLYLVNLYFLYQYSTRLETGAFDGRPADYLFMLLFNWICIVITGLAMDM ..: :: :: .. :. :...: :: :.: :: ::..::.::. . ... :: .. NP_001 FLFF--GP-LGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSL 70 80 90 100 110 120 130 140 150 160 170 pF1KE5 QLLMIPLIMSVLYVWAQLNRDMIVSFWFGTRFKACYLPWVILGFNYIIGGSVINELIGNL .: :. ..:::.. . . :.:. :.: .:::...::. ..:.:.. .:.: NP_001 FFLGQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGIA 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE5 VGHLYFFLMFRYPMDLGGRNFLSTPQFLYRWLPSRRGGVSGFGVPPASMRRAADQNGGGG :::.:.:: .: . ::. .:.:: :: NP_001 VGHIYYFLEDVFPNQPGGKRLLQTPGFLKLLLDAPAEDPNYLPLPEEQPGPHLPPPQQ 180 190 200 210 220 230 >>NP_001129223 (OMIM: 610305) derlin-3 isoform 1 [Homo s (239 aa) initn: 479 init1: 365 opt: 493 Z-score: 632.9 bits: 124.6 E(85289): 1.6e-28 Smith-Waterman score: 495; 33.8% identity (64.6% similar) in 237 aa overlap (8-244:10-234) 10 20 30 40 50 pF1KE5 MSDIGDWFRSIPAITRYWFAATVAVPLVGKLGLISPAYLFLWPEAFLYRFQIWRPITA : ..::.:: . :: : . . .: :.:: :.. :. . .::.:: .: NP_001 MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE5 TFYFPVGPGTGFLYLVNLYFLYQYSTRLETGAFDGRPADYLFMLLFNWICIVITGLAMDM ..: :: :: .. :. :...: :: :.: :: ::..::.::. . ... :: .. NP_001 FLFF--GP-LGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSL 70 80 90 100 110 120 130 140 150 160 170 pF1KE5 QLLMIPLIMSVLYVWAQLNRDMIVSFWFGTRFKACYLPWVILGFNYIIGGSVINELIGNL .: :. ..:::.. . . :.:. :.: .:::...::. ..:.:.. .:.: NP_001 FFLGQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGIA 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE5 VGHLYFFLMFRYPMDLGGRNFLSTPQFLYRWLPSRRGGVSGFGVPPASMRRAADQNGGGG :::.:.:: .: . ::. .:.:: :: :... .: .: :.. :: NP_001 VGHIYYFLEDVFPNQPGGKRLLQTPGFL---------GLQSSKAPAGSSLTIWTQQSQGG 180 190 200 210 220 240 250 pF1KE5 RHNWGQGFRLGDQ . :. NP_001 PGTAGELAAPS 230 >>NP_057125 (OMIM: 610304) derlin-2 isoform a [Homo sapi (239 aa) initn: 516 init1: 370 opt: 487 Z-score: 625.2 bits: 123.1 E(85289): 4.4e-28 Smith-Waterman score: 499; 35.5% identity (63.2% similar) in 242 aa overlap (8-249:10-238) 10 20 30 40 50 pF1KE5 MSDIGDWFRSIPAITRYWFAATVAVPLVGKLGLISPAYLFLWPEAFLYRFQIWRPITA . .:: ..: . .: : . . .: ::.: :.. :: .. .::::: :: NP_057 MAYQSLRLEYLQIPPVSRAYTTACVLTTAAVQLELITPFQLYFNPELIFKHFQIWRLITN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE5 TFYFPVGPGTGFLYLVNLYFLYQYSTRLETGAFDGRPADYLFMLLFNWICIVITGLAMDM ..: :: .:: .: :. :::.: :: :.: :: ::..::.::. . ... :: ... NP_057 FLFF--GP-VGFNFLFNMIFLYRYCRMLEEGSFRGRTADFVFMFLFGGFLMTLFGLFVSL 70 80 90 100 110 120 130 140 150 160 170 pF1KE5 QLLMIPLIMSVLYVWAQLNRDMIVSFWFGTRFKACYLPWVILGFNYIIGGSVINELIGNL .: . . ..:::.. : . ..:. :.: .::::..::. ..:.:.: .:.: NP_057 VFLGQAFTIMLVYVWSRRNPYVRMNFFGLLNFQAPFLPWVLMGFSLLLGNSIIVDLLGIA 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE5 VGHLYFFLMFRYPMDLGGRNFLSTPQFLYRWLPSRRGGVSGFGVPPASMRRAADQNGGGG :::.:::: .: . :: .:.::..: . : .: . . : NP_057 VGHIYFFLEDVFPNQPGGIRILKTPSILK----------AIFDTPDEDPNYNPLPEERPG 180 190 200 210 220 240 250 pF1KE5 RHNWGQGFRLGDQ ::.: ::: NP_057 GFAWGEGQRLGG 230 >>XP_011528807 (OMIM: 610305) PREDICTED: derlin-3 isofor (234 aa) initn: 463 init1: 365 opt: 484 Z-score: 621.5 bits: 122.4 E(85289): 7e-28 Smith-Waterman score: 484; 36.7% identity (68.8% similar) in 199 aa overlap (8-206:10-204) 10 20 30 40 50 pF1KE5 MSDIGDWFRSIPAITRYWFAATVAVPLVGKLGLISPAYLFLWPEAFLYRFQIWRPITA : ..::.:: . :: : . .. : :.:: :.. :. . .::.:: .: XP_011 MAWQGLAAEFLQVPAVTRAYTAACV-LTTAAVLELLSPFQLYFNPHLVFRKFQVWRLVTN 10 20 30 40 50 60 70 80 90 100 110 pF1KE5 TFYFPVGPGTGFLYLVNLYFLYQYSTRLETGAFDGRPADYLFMLLFNWICIVITGLAMDM ..: :: :: .. :. :...: :: :.: :: ::..::.::. . ... :: .. XP_011 FLFF--GP-LGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSL 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE5 QLLMIPLIMSVLYVWAQLNRDMIVSFWFGTRFKACYLPWVILGFNYIIGGSVINELIGNL .: :. ..:::.. . . :.:. :.: .:::...::. ..:.:.. .:.: XP_011 FFLGQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGIA 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE5 VGHLYFFLMFRYPMDLGGRNFLSTPQFLYRWLPSRRGGVSGFGVPPASMRRAADQNGGGG :::.:.:: .: . ::. .:.:: :: XP_011 VGHIYYFLEDVFPNQPGGKRLLQTPGFLKLLLDAPAEDPNYLPLPEEQPGPHLPPPQQ 180 190 200 210 220 230 251 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 22:46:54 2016 done: Mon Nov 7 22:46:55 2016 Total Scan time: 4.270 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]