FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE9420, 337 aa 1>>>pF1KE9420 337 - 337 aa - 337 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.5663+/-0.000445; mu= 20.5567+/- 0.027 mean_var=130.1236+/-33.674, 0's: 0 Z-trim(110.5): 626 B-trim: 1168 in 1/52 Lambda= 0.112434 statistics sampled from 18049 (18860) to 18049 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.556), E-opt: 0.2 (0.221), width: 16 Scan time: 7.100 The best scores are: opt bits E(85289) NP_003958 (OMIM: 607405) trace amine-associated re ( 337) 2286 383.0 5e-106 NP_778227 (OMIM: 608282) trace amine-associated re ( 348) 1052 182.8 9.2e-46 NP_778237 (OMIM: 608923) trace amine-associated re ( 345) 1025 178.4 1.9e-44 NP_444508 (OMIM: 606927) trace amine-associated re ( 342) 1019 177.5 3.7e-44 NP_001028252 (OMIM: 604849) trace amine-associated ( 351) 973 170.0 6.7e-42 NP_055441 (OMIM: 604849) trace amine-associated re ( 306) 923 161.8 1.7e-39 NP_612200 (OMIM: 609333) trace amine-associated re ( 339) 561 103.2 8.6e-22 NP_071640 (OMIM: 142703) histamine H2 receptor iso ( 359) 538 99.5 1.2e-20 XP_006714928 (OMIM: 142703) PREDICTED: histamine H ( 362) 538 99.5 1.2e-20 NP_001124527 (OMIM: 142703) histamine H2 receptor ( 397) 538 99.5 1.2e-20 XP_016864915 (OMIM: 142703) PREDICTED: histamine H ( 422) 538 99.6 1.3e-20 XP_011532851 (OMIM: 142703) PREDICTED: histamine H ( 422) 538 99.6 1.3e-20 XP_011532850 (OMIM: 142703) PREDICTED: histamine H ( 422) 538 99.6 1.3e-20 XP_005265961 (OMIM: 142703) PREDICTED: histamine H ( 422) 538 99.6 1.3e-20 XP_006714927 (OMIM: 142703) PREDICTED: histamine H ( 422) 538 99.6 1.3e-20 NP_000672 (OMIM: 104210) alpha-2A adrenergic recep ( 465) 398 76.9 9.2e-14 NP_001035262 (OMIM: 602164) 5-hydroxytryptamine re ( 360) 395 76.3 1.1e-13 NP_955525 (OMIM: 602164) 5-hydroxytryptamine recep ( 378) 395 76.3 1.2e-13 NP_001035259 (OMIM: 602164) 5-hydroxytryptamine re ( 387) 395 76.3 1.2e-13 NP_000861 (OMIM: 602164) 5-hydroxytryptamine recep ( 388) 395 76.3 1.2e-13 NP_001273339 (OMIM: 602164) 5-hydroxytryptamine re ( 411) 395 76.4 1.2e-13 NP_001035263 (OMIM: 602164) 5-hydroxytryptamine re ( 428) 395 76.4 1.2e-13 NP_001041 (OMIM: 182452) somatostatin receptor typ ( 369) 372 72.6 1.5e-12 NP_000674 (OMIM: 104250) alpha-2C adrenergic recep ( 462) 369 72.2 2.4e-12 NP_001138757 (OMIM: 600018) mu-type opioid recepto ( 389) 365 71.5 3.4e-12 NP_001008504 (OMIM: 600018) mu-type opioid recepto ( 392) 365 71.5 3.4e-12 NP_001138755 (OMIM: 600018) mu-type opioid recepto ( 397) 365 71.5 3.5e-12 NP_000905 (OMIM: 600018) mu-type opioid receptor i ( 400) 365 71.5 3.5e-12 NP_001138756 (OMIM: 600018) mu-type opioid recepto ( 403) 365 71.5 3.5e-12 NP_001138754 (OMIM: 600018) mu-type opioid recepto ( 406) 365 71.5 3.5e-12 NP_001272452 (OMIM: 600018) mu-type opioid recepto ( 414) 365 71.5 3.5e-12 NP_001008503 (OMIM: 600018) mu-type opioid recepto ( 418) 365 71.5 3.6e-12 NP_001138758 (OMIM: 600018) mu-type opioid recepto ( 420) 365 71.5 3.6e-12 NP_001008505 (OMIM: 600018) mu-type opioid recepto ( 446) 365 71.6 3.7e-12 NP_001272453 (OMIM: 600018) mu-type opioid recepto ( 493) 365 71.6 3.9e-12 NP_001138751 (OMIM: 600018) mu-type opioid recepto ( 493) 365 71.6 3.9e-12 XP_016884413 (OMIM: 182453) PREDICTED: somatostati ( 418) 363 71.2 4.5e-12 NP_001042 (OMIM: 182453) somatostatin receptor typ ( 418) 363 71.2 4.5e-12 XP_005261778 (OMIM: 182453) PREDICTED: somatostati ( 418) 363 71.2 4.5e-12 NP_001265616 (OMIM: 182453) somatostatin receptor ( 418) 363 71.2 4.5e-12 XP_011528651 (OMIM: 182453) PREDICTED: somatostati ( 418) 363 71.2 4.5e-12 XP_016884412 (OMIM: 182453) PREDICTED: somatostati ( 418) 363 71.2 4.5e-12 XP_006724374 (OMIM: 182453) PREDICTED: somatostati ( 418) 363 71.2 4.5e-12 NP_000015 (OMIM: 109690,600807,601665) beta-2 adre ( 413) 359 70.5 6.9e-12 NP_000902 (OMIM: 165195) delta-type opioid recepto ( 372) 352 69.3 1.4e-11 NP_000673 (OMIM: 104260,607876) alpha-2B adrenergi ( 450) 351 69.3 1.8e-11 NP_004239 (OMIM: 600895) prolactin-releasing pepti ( 370) 349 68.8 2e-11 NP_000855 (OMIM: 182133) 5-hydroxytryptamine recep ( 377) 344 68.0 3.6e-11 NP_057624 (OMIM: 605569) probable G-protein couple ( 423) 340 67.5 6e-11 NP_001243689 (OMIM: 312861) 5-hydroxytryptamine re ( 458) 340 67.5 6.2e-11 >>NP_003958 (OMIM: 607405) trace amine-associated recept (337 aa) initn: 2286 init1: 2286 opt: 2286 Z-score: 2024.4 bits: 383.0 E(85289): 5e-106 Smith-Waterman score: 2286; 100.0% identity (100.0% similar) in 337 aa overlap (1-337:1-337) 10 20 30 40 50 60 pF1KE9 MRAVFIQGAEEHPAAFCYQVNGSCPRTVHTLGIQLVIYLACAAGMLIIVLGNVFVAFAVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MRAVFIQGAEEHPAAFCYQVNGSCPRTVHTLGIQLVIYLACAAGMLIIVLGNVFVAFAVS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 YFKALHTPTNFLLLSLALADMFLGLLVLPLSTIRSVESCWFFGDFLCRLHTYLDTLFCLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 YFKALHTPTNFLLLSLALADMFLGLLVLPLSTIRSVESCWFFGDFLCRLHTYLDTLFCLT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 SIFHLCFISIDRHCAICDPLLYPSKFTVRVALRYILAGWGVPAAYTSLFLYTDVVETRLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 SIFHLCFISIDRHCAICDPLLYPSKFTVRVALRYILAGWGVPAAYTSLFLYTDVVETRLS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 QWLEEMPCVGSCQLLLNKFWGWLNFPLFFVPCLIMISLYVKIFVVATRQAQQITTLSKSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 QWLEEMPCVGSCQLLLNKFWGWLNFPLFFVPCLIMISLYVKIFVVATRQAQQITTLSKSL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 AGAAKHERKAAKTLGIAVGIYLLCWLPFTIDTMVDSLLHFITPPLVFDIFIWFAYFNSAC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 AGAAKHERKAAKTLGIAVGIYLLCWLPFTIDTMVDSLLHFITPPLVFDIFIWFAYFNSAC 250 260 270 280 290 300 310 320 330 pF1KE9 NPIIYVFSYQWFRKALKLTLSQKVFSPQTRTVDLYQE ::::::::::::::::::::::::::::::::::::: NP_003 NPIIYVFSYQWFRKALKLTLSQKVFSPQTRTVDLYQE 310 320 330 >>NP_778227 (OMIM: 608282) trace amine-associated recept (348 aa) initn: 1100 init1: 690 opt: 1052 Z-score: 942.5 bits: 182.8 E(85289): 9.2e-46 Smith-Waterman score: 1052; 46.2% identity (75.5% similar) in 331 aa overlap (16-337:13-343) 10 20 30 40 50 pF1KE9 MRAVFIQGAEEHPAAFCYQ-VNGSCPRTVHTLGIQLVIYLACAAGMLIIVLGNVFVAFAV .::. :: :: .: .. : . ..: . . : .. ..::..: .:. NP_778 MVNNFSQAEAVELCYKNVNESCIKTPYSPGPRSILYAVLGFGAVLAAFGNLLVMIAI 10 20 30 40 50 60 70 80 90 100 110 pF1KE9 SYFKALHTPTNFLLLSLALADMFLGLLVLPLSTIRSVESCWFFGDFLCRLHTYLDTLFCL .:: ::::::::. ::: ::...:. :.:.::.:::::::.::: :..:: .:: ::. NP_778 LHFKQLHTPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGDSYCKFHTCFDTSFCF 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE9 TSIFHLCFISIDRHCAICDPLLYPSKFTVRVALRYILAGWGVPAAYTSLFLYTDVVETRL .:.:::: ::.::. :. ::: ::.:::: :. :. .: ..:. ..:: . : . NP_778 ASLFHLCCISVDRYIAVTDPLTYPTKFTVSVSGICIVLSWFFSVTYSFSIFYTGANEEGI 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE9 SQWLEEMPCVGSCQLLLNKFWGWLNFPLFFVPCLIMISLYVKIFVVATRQAQQI-TTLSK . . . :::.:: ::. : : : :::.: . :. .: :::.:: .::..: .: :. NP_778 EELVVALTCVGGCQAPLNQNWVLLCFLLFFIPNVAMVFIYSKIFLVAKHQARKIESTASQ 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE9 SLAGA-------AKHERKAAKTLGIAVGIYLLCWLPFTIDTMVDSLLHFITPPLVFDIFI . ... ::.:::::::::::.. .:. :::. .:...:. ..::::: :..:.. NP_778 AQSSSESYKERVAKRERKAAKTLGIAMAAFLVSWLPYLVDAVIDAYMNFITPPYVYEILV 240 250 260 270 280 290 300 310 320 330 pF1KE9 WFAYFNSACNPIIYVFSYQWFRKALKLTLSQKVFSPQTRTVDLYQE : .:.::: ::.::.: :::: ::.:: .: ::. .. :..:..: NP_778 WCVYYNSAMNPLIYAFFYQWFGKAIKLIVSGKVLRTDSSTTNLFSEEVETD 300 310 320 330 340 >>NP_778237 (OMIM: 608923) trace amine-associated recept (345 aa) initn: 1037 init1: 699 opt: 1025 Z-score: 918.9 bits: 178.4 E(85289): 1.9e-44 Smith-Waterman score: 1025; 43.8% identity (74.9% similar) in 331 aa overlap (16-337:13-343) 10 20 30 40 50 pF1KE9 MRAVFIQGAEEHPAAFCY-QVNGSCPRTVHTLGIQLVIYLACAAGMLIIVLGNVFVAFAV .:: .::::: . . : ....:.. . : .. :.::..: ... NP_778 MSSNSSLLVAVQLCYANVNGSCVKIPFSPGSRVILYIVFGFGAVLAVFGNLLVMISI 10 20 30 40 50 60 70 80 90 100 110 pF1KE9 SYFKALHTPTNFLLLSLALADMFLGLLVLPLSTIRSVESCWFFGDFLCRLHTYLDTLFCL .:: ::.:::::. ::: ::...:. :.:.: .:.:::::.:: .: .:: :. :: NP_778 LHFKQLHSPTNFLVASLACADFLVGVTVMPFSMVRTVESCWYFGRSFCTFHTCCDVAFCY 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE9 TSIFHLCFISIDRHCAICDPLLYPSKFTVRVALRYILAGWGVPAAYTSLFLYTDVVETRL .:.::::::::::. :. :::.::.:::: :. : ..: .: :.. .:: : . : NP_778 SSLFHLCFISIDRYIAVTDPLVYPTKFTVSVSGICISVSWILPLMYSGAVFYTGVYDDGL 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE9 SQWLEEMPCVGSCQLLLNKFWGWLNFPLFFVPCLIMISLYVKIFVVATRQAQQI-TTLSK . . . :.:.:: ..:. : .: ::.: .::: :: .::.:: :::..: .: :: NP_778 EELSDALNCIGGCQTVVNQNWVLTDFLSFFIPTFIMIILYGNIFLVARRQAKKIENTGSK 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE9 SLAGA-------AKHERKAAKTLGIAVGIYLLCWLPFTIDTMVDSLLHFITPPLVFDIFI . ... :..:::::::::..: ... :::..::...:... :::: ...: NP_778 TESSSESYKARVARRERKAAKTLGVTVVAFMISWLPYSIDSLIDAFMGFITPACIYEICC 240 250 260 270 280 290 300 310 320 330 pF1KE9 WFAYFNSACNPIIYVFSYQWFRKALKLTLSQKVFSPQTRTVDLYQE : ::.::: ::.::.. : :::::.:. .. .:.. .. :..:..: NP_778 WCAYYNSAMNPLIYALFYPWFRKAIKVIVTGQVLKNSSATMNLFSEHI 300 310 320 330 340 >>NP_444508 (OMIM: 606927) trace amine-associated recept (342 aa) initn: 1063 init1: 690 opt: 1019 Z-score: 913.7 bits: 177.5 E(85289): 3.7e-44 Smith-Waterman score: 1019; 44.1% identity (73.7% similar) in 331 aa overlap (16-337:12-342) 10 20 30 40 50 pF1KE9 MRAVFIQGAEEHPAAFCYQ-VNGSCPRTVHTLGIQLVIYLACAAGMLIIVLGNVFVAFAV .::. ::::: .: .. : ....: : . : :. :.::..: .: NP_444 MTSNFSQPVVQLCYEDVNGSCIETPYSPGSRVILYTAFSFGSLLAVFGNLLVMTSV 10 20 30 40 50 60 70 80 90 100 110 pF1KE9 SYFKALHTPTNFLLLSLALADMFLGLLVLPLSTIRSVESCWFFGDFLCRLHTYLDTLFCL .:: ::.:::::. ::: ::...:. :. .: .:.:::::.:: .: ::. :. :: NP_444 LHFKQLHSPTNFLIASLACADFLVGVTVMLFSMVRTVESCWYFGAKFCTLHSCCDVAFCY 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE9 TSIFHLCFISIDRHCAICDPLLYPSKFTVRVALRYILAGWGVPAAYTSLFLYTDVVETRL .:..::::: :::. .. :::.: .:::: :. : ..: .: .:.. .:: : . : NP_444 SSVLHLCFICIDRYIVVTDPLVYATKFTVSVSGICISVSWILPLTYSGAVFYTGVNDDGL 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE9 SQWLEEMPCVGSCQLLLNKFWGWLNFPLFFVPCLIMISLYVKIFVVATRQAQQITTLSKS . . . :::.::..... : ..: :::.: :.:: :: :::..: .:: .: : :.. NP_444 EELVSALNCVGGCQIIVSQGWVLIDFLLFFIPTLVMIILYSKIFLIAKQQAIKIETTSSK 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE9 LAGA--------AKHERKAAKTLGIAVGIYLLCWLPFTIDTMVDSLLHFITPPLVFDIFI . .. ::.:::::::::..: ... :::.:.: ..:... :.:: ...: NP_444 VESSSESYKIRVAKRERKAAKTLGVTVLAFVISWLPYTVDILIDAFMGFLTPAYIYEICC 240 250 260 270 280 290 300 310 320 330 pF1KE9 WFAYFNSACNPIIYVFSYQWFRKALKLTLSQKVFSPQTRTVDLYQE : ::.::: ::.::.. : :::::.:: :: :.. .. :..:. : NP_444 WSAYYNSAMNPLIYALFYPWFRKAIKLILSGDVLKASSSTISLFLE 300 310 320 330 340 >>NP_001028252 (OMIM: 604849) trace amine-associated rec (351 aa) initn: 976 init1: 566 opt: 973 Z-score: 873.3 bits: 170.0 E(85289): 6.7e-42 Smith-Waterman score: 973; 43.3% identity (75.6% similar) in 307 aa overlap (21-326:30-336) 10 20 30 40 50 pF1KE9 MRAVFIQGAEEHPAAFCYQVNGSCPRTVHTLGIQLVIYLACAAGMLIIVLG : :::.. ..::.....: :....: ..: NP_001 MAVSSEQHELSHFKRTQTKKEKFNCSEYGNRSCPENERSLGVRVAMYSFMAGSIFITIFG 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE9 NVFVAFAVSYFKALHTPTNFLLLSLALADMFLGLLVLPLSTIRSVESCWFFGDFLCRLHT :. . ...:::: ::::::::.::.:..:..::. ..: : :::::.::.:: .:... NP_001 NLAMIISISYFKQLHTPTNFLILSMAITDFLLGFTIMPYSMIRSVENCWYFGLTFCKIYY 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE9 YLDTLFCLTSIFHLCFISIDRHCAICDPLLYPSKFTVRVALRYILAGWGVPAAYTSLFLY .: .. .::::::: ..::: ::: :::: .:.:. : : .: :.::.:.. .. NP_001 SFDLMLSITSIFHLCSVAIDRFYAICYPLLYSTKITIPVIKRLLLLCWSVPGAFAFGVVF 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE9 TDVVETRLSQWLEEMPCVGSCQLLLNKFWGWLNFPL-FFVPCLIMISLYVKIFVVATRQA ... . . . : .:: ...::.:: : ::.: .:...: :::.:. ..: NP_001 SEAYADGIEGYDILVACSSSCPVMFNKLWGTTLFMAGFFTPGSMMVGIYGKIFAVSRKHA 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE9 QQITTLSKSLAGAAKHERKAAKTLGIAVGIYLLCWLPFTIDTMVDSLLHFITPPLVFDIF . :..: .. . .:...::::::::..:..::::.: . ..: .:.: :: ..:: . NP_001 HAINNLRENQNNQVKKDKKAAKTLGIVIGVFLLCWFPCFFTILLDPFLNFSTPVVLFDAL 250 260 270 280 290 300 300 310 320 330 pF1KE9 IWFAYFNSACNPIIYVFSYQWFRKALKLTLSQKVFSPQTRTVDLYQE ::.::::.:::.:: : : :::.::: : :.:: NP_001 TWFGYFNSTCNPLIYGFFYPWFRRALKYILLGKIFSSCFHNTILCMQKESE 310 320 330 340 350 >>NP_055441 (OMIM: 604849) trace amine-associated recept (306 aa) initn: 924 init1: 514 opt: 923 Z-score: 830.0 bits: 161.8 E(85289): 1.7e-39 Smith-Waterman score: 923; 43.6% identity (74.9% similar) in 291 aa overlap (37-326:1-291) 10 20 30 40 50 60 pF1KE9 QGAEEHPAAFCYQVNGSCPRTVHTLGIQLVIYLACAAGMLIIVLGNVFVAFAVSYFKALH .: :....: ..::. . ...:::: :: NP_055 MYSFMAGSIFITIFGNLAMIISISYFKQLH 10 20 30 70 80 90 100 110 120 pF1KE9 TPTNFLLLSLALADMFLGLLVLPLSTIRSVESCWFFGDFLCRLHTYLDTLFCLTSIFHLC ::::::.::.:..:..::. ..: : :::::.::.:: .:... .: .. .::::::: NP_055 TPTNFLILSMAITDFLLGFTIMPYSMIRSVENCWYFGLTFCKIYYSFDLMLSITSIFHLC 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE9 FISIDRHCAICDPLLYPSKFTVRVALRYILAGWGVPAAYTSLFLYTDVVETRLSQWLEEM ..::: ::: :::: .:.:. : : .: :.::.:.. ..... . . . NP_055 SVAIDRFYAICYPLLYSTKITIPVIKRLLLLCWSVPGAFAFGVVFSEAYADGIEGYDILV 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE9 PCVGSCQLLLNKFWGWLNFPL-FFVPCLIMISLYVKIFVVATRQAQQITTLSKSLAGAAK : .:: ...::.:: : ::.: .:...: :::.:. ..:. :..: .. . .: NP_055 ACSSSCPVMFNKLWGTTLFMAGFFTPGSMMVGIYGKIFAVSRKHAHAINNLRENQNNQVK 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE9 HERKAAKTLGIAVGIYLLCWLPFTIDTMVDSLLHFITPPLVFDIFIWFAYFNSACNPIIY ...::::::::..:..::::.: . ..: .:.: :: ..:: . ::.::::.:::.:: NP_055 KDKKAAKTLGIVIGVFLLCWFPCFFTILLDPFLNFSTPVVLFDALTWFGYFNSTCNPLIY 220 230 240 250 260 270 310 320 330 pF1KE9 VFSYQWFRKALKLTLSQKVFSPQTRTVDLYQE : : :::.::: : :.:: NP_055 GFFYPWFRRALKYILLGKIFSSCFHNTILCMQKESE 280 290 300 >>NP_612200 (OMIM: 609333) trace amine-associated recept (339 aa) initn: 762 init1: 440 opt: 561 Z-score: 512.2 bits: 103.2 E(85289): 8.6e-22 Smith-Waterman score: 893; 39.0% identity (71.5% similar) in 333 aa overlap (16-337:4-336) 10 20 30 40 50 pF1KE9 MRAVFIQGAEEHPAAFCYQV-NGSCPRTVHTLGIQLVIYLACAAGMLIIVLGNVFVAFAV ::... : :: .. . .. .: . .: ..::..: .. NP_612 MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSI 10 20 30 40 60 70 80 90 100 110 pF1KE9 SYFKALHTPTNFLLLSLALADMFLGLLVLPLSTIRSVESCWFFGDFLCRLHTYLDTLFCL :.:: ::::::.:. :.: .:..:: ::.: : .::.: ::.::. .:..:: : .. NP_612 SHFKQLHTPTNWLIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSS 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE9 TSIFHLCFISIDRHCAICDPLLYPSKFTVRVALRYILAGWGVPAAYTSLFLYTDVVETRL .::::: ::::::. :.:::: : .:... : .:. .:.:::... ... .. NP_612 ASIFHLSFISIDRYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGA 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE9 SQ-WLEEMPCVGSCQLLLNKFWGWLNFPL-FFVPCLIMISLYVKIFVVATRQAQQITTLS . . ... : :.:.....:. : :.: :..: ::. .: .:...: .::. :. . NP_612 EEIYYKHVHCRGGCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDAN 170 180 190 200 210 220 240 250 260 270 280 pF1KE9 KSLA-------GAAK-HERKAAKTLGIAVGIYLLCWLPFTIDTMVDSLLHFITPPLVFDI ..: : .. .::::.:::::..:..:.:: :: : :..: .::.: :: . :. NP_612 QKLQIGLEMKNGISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDV 230 240 250 260 270 280 290 300 310 320 330 pF1KE9 FIWFAYFNSACNPIIYVFSYQWFRKALKLTLSQKVFSPQTRTVDLYQE .:::.:.::. ::..:.: : :::::::. : :.:. .. :. : NP_612 LIWFGYLNSTFNPMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLELSS 290 300 310 320 330 >>NP_071640 (OMIM: 142703) histamine H2 receptor isoform (359 aa) initn: 432 init1: 321 opt: 538 Z-score: 491.8 bits: 99.5 E(85289): 1.2e-20 Smith-Waterman score: 538; 35.7% identity (66.4% similar) in 283 aa overlap (34-313:18-296) 10 20 30 40 50 60 pF1KE9 VFIQGAEEHPAAFCYQVNGSCPRTVHTLGIQLVIYLACAAGMLIIVLGNVFVAFAVSYFK ...: .. :. .:: : ::: : .::. . NP_071 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNR 10 20 30 40 70 80 90 100 110 120 pF1KE9 ALHTPTNFLLLSLALADMFLGLLVLPLSTIRSVESCWFFGDFLCRLHTYLDTLFCLTSIF :.. :: ...:::..:..:::::::.:.: .. : :: .: ..: ::...: .::. NP_071 RLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASIL 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE9 HLCFISIDRHCAICDPLLYPSKFT-VRVALRYILAGWGVPAAYTSLFLYTDVVETRLSQW .: .::.::.::. ::: :: : ::::. .: : . . : :: . . .. NP_071 NLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLI-WVI--SITLSFLSIHLGWNSRNET 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE9 LEEMPCVGSCQLLLNKFWGWLN-FPLFFVPCLIMISLYVKIFVVATRQAQQITTLSKSLA . ...:.. .:. .: .. . :..: ::: : .:: :: ::..:. .: : NP_071 SKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHIS-SWK 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE9 GAAKHERKAAKTLGIAVGIYLLCWLPFTIDTMVDSLLHFITPPLVFD-IFIWFAYFNSAC .:. .:.::. ::. ..: ...::.:. . .: . :.. : .:..: ::: NP_071 AATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSAL 230 240 250 260 270 280 310 320 330 pF1KE9 NPIIYVFSYQWFRKALKLTLSQKVFSPQTRTVDLYQE :::.:. . :: NP_071 NPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQ 290 300 310 320 330 340 >>XP_006714928 (OMIM: 142703) PREDICTED: histamine H2 re (362 aa) initn: 432 init1: 321 opt: 538 Z-score: 491.8 bits: 99.5 E(85289): 1.2e-20 Smith-Waterman score: 538; 35.7% identity (66.4% similar) in 283 aa overlap (34-313:18-296) 10 20 30 40 50 60 pF1KE9 VFIQGAEEHPAAFCYQVNGSCPRTVHTLGIQLVIYLACAAGMLIIVLGNVFVAFAVSYFK ...: .. :. .:: : ::: : .::. . XP_006 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNR 10 20 30 40 70 80 90 100 110 120 pF1KE9 ALHTPTNFLLLSLALADMFLGLLVLPLSTIRSVESCWFFGDFLCRLHTYLDTLFCLTSIF :.. :: ...:::..:..:::::::.:.: .. : :: .: ..: ::...: .::. XP_006 RLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASIL 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE9 HLCFISIDRHCAICDPLLYPSKFT-VRVALRYILAGWGVPAAYTSLFLYTDVVETRLSQW .: .::.::.::. ::: :: : ::::. .: : . . : :: . . .. XP_006 NLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLI-WVI--SITLSFLSIHLGWNSRNET 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE9 LEEMPCVGSCQLLLNKFWGWLN-FPLFFVPCLIMISLYVKIFVVATRQAQQITTLSKSLA . ...:.. .:. .: .. . :..: ::: : .:: :: ::..:. .: : XP_006 SKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHIS-SWK 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE9 GAAKHERKAAKTLGIAVGIYLLCWLPFTIDTMVDSLLHFITPPLVFD-IFIWFAYFNSAC .:. .:.::. ::. ..: ...::.:. . .: . :.. : .:..: ::: XP_006 AATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSAL 230 240 250 260 270 280 310 320 330 pF1KE9 NPIIYVFSYQWFRKALKLTLSQKVFSPQTRTVDLYQE :::.:. . :: XP_006 NPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQ 290 300 310 320 330 340 >>NP_001124527 (OMIM: 142703) histamine H2 receptor isof (397 aa) initn: 432 init1: 321 opt: 538 Z-score: 491.4 bits: 99.5 E(85289): 1.2e-20 Smith-Waterman score: 538; 35.7% identity (66.4% similar) in 283 aa overlap (34-313:18-296) 10 20 30 40 50 60 pF1KE9 VFIQGAEEHPAAFCYQVNGSCPRTVHTLGIQLVIYLACAAGMLIIVLGNVFVAFAVSYFK ...: .. :. .:: : ::: : .::. . NP_001 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNR 10 20 30 40 70 80 90 100 110 120 pF1KE9 ALHTPTNFLLLSLALADMFLGLLVLPLSTIRSVESCWFFGDFLCRLHTYLDTLFCLTSIF :.. :: ...:::..:..:::::::.:.: .. : :: .: ..: ::...: .::. NP_001 RLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASIL 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE9 HLCFISIDRHCAICDPLLYPSKFT-VRVALRYILAGWGVPAAYTSLFLYTDVVETRLSQW .: .::.::.::. ::: :: : ::::. .: : . . : :: . . .. NP_001 NLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLI-WVI--SITLSFLSIHLGWNSRNET 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE9 LEEMPCVGSCQLLLNKFWGWLN-FPLFFVPCLIMISLYVKIFVVATRQAQQITTLSKSLA . ...:.. .:. .: .. . :..: ::: : .:: :: ::..:. .: : NP_001 SKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHIS-SWK 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE9 GAAKHERKAAKTLGIAVGIYLLCWLPFTIDTMVDSLLHFITPPLVFD-IFIWFAYFNSAC .:. .:.::. ::. ..: ...::.:. . .: . :.. : .:..: ::: NP_001 AATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSAL 230 240 250 260 270 280 310 320 330 pF1KE9 NPIIYVFSYQWFRKALKLTLSQKVFSPQTRTVDLYQE :::.:. . :: NP_001 NPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQ 290 300 310 320 330 340 337 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 16:29:47 2016 done: Sun Nov 6 16:29:48 2016 Total Scan time: 7.100 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]