FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7036, 397 aa 1>>>pF1KB7036 397 - 397 aa - 397 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0897+/-0.000471; mu= 18.6611+/- 0.029 mean_var=104.7866+/-27.145, 0's: 0 Z-trim(110.0): 731 B-trim: 771 in 1/48 Lambda= 0.125291 statistics sampled from 17447 (18286) to 17447 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.569), E-opt: 0.2 (0.214), width: 16 Scan time: 6.970 The best scores are: opt bits E(85289) NP_001124527 (OMIM: 142703) histamine H2 receptor ( 397) 2642 489.0 8.4e-138 XP_011532850 (OMIM: 142703) PREDICTED: histamine H ( 422) 2362 438.4 1.5e-122 XP_006714927 (OMIM: 142703) PREDICTED: histamine H ( 422) 2362 438.4 1.5e-122 XP_011532851 (OMIM: 142703) PREDICTED: histamine H ( 422) 2362 438.4 1.5e-122 XP_005265961 (OMIM: 142703) PREDICTED: histamine H ( 422) 2362 438.4 1.5e-122 XP_016864915 (OMIM: 142703) PREDICTED: histamine H ( 422) 2362 438.4 1.5e-122 NP_071640 (OMIM: 142703) histamine H2 receptor iso ( 359) 2352 436.5 4.7e-122 XP_006714928 (OMIM: 142703) PREDICTED: histamine H ( 362) 2352 436.5 4.8e-122 NP_003958 (OMIM: 607405) trace amine-associated re ( 337) 538 108.6 2.3e-23 NP_000785 (OMIM: 126449) D(1A) dopamine receptor [ ( 446) 522 105.9 2.1e-22 NP_001035262 (OMIM: 602164) 5-hydroxytryptamine re ( 360) 520 105.4 2.3e-22 NP_955525 (OMIM: 602164) 5-hydroxytryptamine recep ( 378) 520 105.4 2.4e-22 NP_001035259 (OMIM: 602164) 5-hydroxytryptamine re ( 387) 520 105.4 2.4e-22 NP_000861 (OMIM: 602164) 5-hydroxytryptamine recep ( 388) 520 105.4 2.4e-22 NP_001273339 (OMIM: 602164) 5-hydroxytryptamine re ( 411) 520 105.5 2.5e-22 NP_001028252 (OMIM: 604849) trace amine-associated ( 351) 519 105.2 2.6e-22 NP_001035263 (OMIM: 602164) 5-hydroxytryptamine re ( 428) 520 105.5 2.6e-22 XP_011542713 (OMIM: 104221) PREDICTED: alpha-1A ad ( 324) 513 104.1 5.2e-22 NP_055441 (OMIM: 604849) trace amine-associated re ( 306) 512 103.9 5.7e-22 XP_011542714 (OMIM: 104221) PREDICTED: alpha-1A ad ( 308) 511 103.7 6.4e-22 XP_016868585 (OMIM: 104221) PREDICTED: alpha-1A ad ( 317) 511 103.7 6.6e-22 NP_001309433 (OMIM: 104221) alpha-1A adrenergic re ( 342) 511 103.7 6.9e-22 NP_001309432 (OMIM: 104221) alpha-1A adrenergic re ( 370) 511 103.8 7.2e-22 NP_001309431 (OMIM: 104221) alpha-1A adrenergic re ( 372) 511 103.8 7.3e-22 XP_005265876 (OMIM: 104220) PREDICTED: alpha-1B ad ( 328) 510 103.5 7.6e-22 XP_006714884 (OMIM: 104220) PREDICTED: alpha-1B ad ( 331) 510 103.5 7.6e-22 NP_150645 (OMIM: 104221) alpha-1A adrenergic recep ( 429) 511 103.8 7.9e-22 XP_006716356 (OMIM: 104221) PREDICTED: alpha-1A ad ( 429) 511 103.8 7.9e-22 XP_005265875 (OMIM: 104220) PREDICTED: alpha-1B ad ( 366) 510 103.6 8.1e-22 NP_150647 (OMIM: 104221) alpha-1A adrenergic recep ( 455) 511 103.9 8.3e-22 NP_000671 (OMIM: 104221) alpha-1A adrenergic recep ( 466) 511 103.9 8.4e-22 XP_011532740 (OMIM: 104220) PREDICTED: alpha-1B ad ( 389) 510 103.6 8.5e-22 XP_016868584 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 511 103.9 8.5e-22 XP_016868583 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 511 103.9 8.5e-22 NP_150646 (OMIM: 104221) alpha-1A adrenergic recep ( 475) 511 103.9 8.5e-22 XP_006716355 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 511 103.9 8.5e-22 XP_011532739 (OMIM: 104220) PREDICTED: alpha-1B ad ( 402) 510 103.6 8.6e-22 NP_000670 (OMIM: 104220) alpha-1B adrenergic recep ( 520) 510 103.8 1e-21 XP_011532737 (OMIM: 104220) PREDICTED: alpha-1B ad ( 556) 510 103.8 1.1e-21 NP_000675 (OMIM: 109630,607276) beta-1 adrenergic ( 477) 509 103.5 1.1e-21 NP_000669 (OMIM: 104219) alpha-1D adrenergic recep ( 572) 509 103.6 1.2e-21 NP_000015 (OMIM: 109690,600807,601665) beta-2 adre ( 413) 490 100.0 1.1e-20 NP_000515 (OMIM: 109760,614674) 5-hydroxytryptamin ( 422) 483 98.8 2.6e-20 NP_000016 (OMIM: 109691,601665) beta-3 adrenergic ( 408) 477 97.7 5.5e-20 NP_000862 (OMIM: 601109) 5-hydroxytryptamine recep ( 440) 453 93.4 1.2e-18 NP_612200 (OMIM: 609333) trace amine-associated re ( 339) 450 92.7 1.4e-18 NP_062874 (OMIM: 182137) 5-hydroxytryptamine recep ( 432) 444 91.7 3.5e-18 NP_000863 (OMIM: 182137) 5-hydroxytryptamine recep ( 445) 444 91.8 3.6e-18 NP_062873 (OMIM: 182137) 5-hydroxytryptamine recep ( 479) 444 91.8 3.8e-18 NP_000672 (OMIM: 104210) alpha-2A adrenergic recep ( 465) 441 91.2 5.4e-18 >>NP_001124527 (OMIM: 142703) histamine H2 receptor isof (397 aa) initn: 2642 init1: 2642 opt: 2642 Z-score: 2595.0 bits: 489.0 E(85289): 8.4e-138 Smith-Waterman score: 2642; 100.0% identity (100.0% similar) in 397 aa overlap (1-397:1-397) 10 20 30 40 50 60 pF1KB7 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDRP 310 320 330 340 350 360 370 380 390 pF1KB7 WLCLPECWSVELTHSFIHLFIHSFANIHPIPTTCQEL ::::::::::::::::::::::::::::::::::::: NP_001 WLCLPECWSVELTHSFIHLFIHSFANIHPIPTTCQEL 370 380 390 >>XP_011532850 (OMIM: 142703) PREDICTED: histamine H2 re (422 aa) initn: 2352 init1: 2352 opt: 2362 Z-score: 2321.1 bits: 438.4 E(85289): 1.5e-122 Smith-Waterman score: 2362; 97.3% identity (97.6% similar) in 374 aa overlap (1-373:1-374) 10 20 30 40 50 60 pF1KB7 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ 250 260 270 280 290 300 310 320 330 340 350 pF1KB7 QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR- ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDRK 310 320 330 340 350 360 360 370 380 390 pF1KB7 PWLCLPECWSVELTHSFIHLFIHSFANIHPIPTTCQEL : : : : :. XP_011 PALSCTTCSSNLLSCCKSLWGLRFLQRHMGGPSEELSGEPLSEEPQKRPPQKAVRTLPSE 370 380 390 400 410 420 >>XP_006714927 (OMIM: 142703) PREDICTED: histamine H2 re (422 aa) initn: 2352 init1: 2352 opt: 2362 Z-score: 2321.1 bits: 438.4 E(85289): 1.5e-122 Smith-Waterman score: 2362; 97.3% identity (97.6% similar) in 374 aa overlap (1-373:1-374) 10 20 30 40 50 60 pF1KB7 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ 250 260 270 280 290 300 310 320 330 340 350 pF1KB7 QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR- ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDRK 310 320 330 340 350 360 360 370 380 390 pF1KB7 PWLCLPECWSVELTHSFIHLFIHSFANIHPIPTTCQEL : : : : :. XP_006 PALSCTTCSSNLLSCCKSLWGLRFLQRHMGGPSEELSGEPLSEEPQKRPPQKAVRTLPSE 370 380 390 400 410 420 >>XP_011532851 (OMIM: 142703) PREDICTED: histamine H2 re (422 aa) initn: 2352 init1: 2352 opt: 2362 Z-score: 2321.1 bits: 438.4 E(85289): 1.5e-122 Smith-Waterman score: 2362; 97.3% identity (97.6% similar) in 374 aa overlap (1-373:1-374) 10 20 30 40 50 60 pF1KB7 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ 250 260 270 280 290 300 310 320 330 340 350 pF1KB7 QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR- ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDRK 310 320 330 340 350 360 360 370 380 390 pF1KB7 PWLCLPECWSVELTHSFIHLFIHSFANIHPIPTTCQEL : : : : :. XP_011 PALSCTTCSSNLLSCCKSLWGLRFLQRHMGGPSEELSGEPLSEEPQKRPPQKAVRTLPSE 370 380 390 400 410 420 >>XP_005265961 (OMIM: 142703) PREDICTED: histamine H2 re (422 aa) initn: 2352 init1: 2352 opt: 2362 Z-score: 2321.1 bits: 438.4 E(85289): 1.5e-122 Smith-Waterman score: 2362; 97.3% identity (97.6% similar) in 374 aa overlap (1-373:1-374) 10 20 30 40 50 60 pF1KB7 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ 250 260 270 280 290 300 310 320 330 340 350 pF1KB7 QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR- ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDRK 310 320 330 340 350 360 360 370 380 390 pF1KB7 PWLCLPECWSVELTHSFIHLFIHSFANIHPIPTTCQEL : : : : :. XP_005 PALSCTTCSSNLLSCCKSLWGLRFLQRHMGGPSEELSGEPLSEEPQKRPPQKAVRTLPSE 370 380 390 400 410 420 >>XP_016864915 (OMIM: 142703) PREDICTED: histamine H2 re (422 aa) initn: 2352 init1: 2352 opt: 2362 Z-score: 2321.1 bits: 438.4 E(85289): 1.5e-122 Smith-Waterman score: 2362; 97.3% identity (97.6% similar) in 374 aa overlap (1-373:1-374) 10 20 30 40 50 60 pF1KB7 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ 250 260 270 280 290 300 310 320 330 340 350 pF1KB7 QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR- ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDRK 310 320 330 340 350 360 360 370 380 390 pF1KB7 PWLCLPECWSVELTHSFIHLFIHSFANIHPIPTTCQEL : : : : :. XP_016 PALSCTTCSSNLLSCCKSLWGLRFLQRHMGGPSEELSGEPLSEEPQKRPPQKAVRTLPSE 370 380 390 400 410 420 >>NP_071640 (OMIM: 142703) histamine H2 receptor isoform (359 aa) initn: 2352 init1: 2352 opt: 2352 Z-score: 2312.2 bits: 436.5 E(85289): 4.7e-122 Smith-Waterman score: 2352; 100.0% identity (100.0% similar) in 359 aa overlap (1-359:1-359) 10 20 30 40 50 60 pF1KB7 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDRP ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR 310 320 330 340 350 370 380 390 pF1KB7 WLCLPECWSVELTHSFIHLFIHSFANIHPIPTTCQEL >>XP_006714928 (OMIM: 142703) PREDICTED: histamine H2 re (362 aa) initn: 2352 init1: 2352 opt: 2352 Z-score: 2312.1 bits: 436.5 E(85289): 4.8e-122 Smith-Waterman score: 2352; 100.0% identity (100.0% similar) in 359 aa overlap (1-359:1-359) 10 20 30 40 50 60 pF1KB7 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDRP ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDRN 310 320 330 340 350 360 370 380 390 pF1KB7 WLCLPECWSVELTHSFIHLFIHSFANIHPIPTTCQEL XP_006 SS >>NP_003958 (OMIM: 607405) trace amine-associated recept (337 aa) initn: 432 init1: 321 opt: 538 Z-score: 540.4 bits: 108.6 E(85289): 2.3e-23 Smith-Waterman score: 538; 35.3% identity (66.4% similar) in 283 aa overlap (18-296:34-313) 10 20 30 40 pF1KB7 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNR ...: .. :. .:: : ::: : .::. . NP_003 VFIQGAEEHPAAFCYQVNGSCPRTVHTLGIQLVIYLACAAGMLIIVLGNVFVAFAVSYFK 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB7 RLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASIL :.. :: ...:::..:..:::::::.:.: .. : :: .: ..: ::...: .::. NP_003 ALHTPTNFLLLSLALADMFLGLLVLPLSTIRSVESCWFFGDFLCRLHTYLDTLFCLTSIF 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB7 NLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLI-WVISITLS--FLSIHLGWNSRNET .: .::.::.::. ::: :: : ::::. .: : . . . :: . . .. NP_003 HLCFISIDRHCAICDPLLYPSKFT-VRVALRYILAGWGVPAAYTSLFLYTDVVETRLSQW 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB7 SKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHIS-SWK . ...:.. .:. .: .. . :..: ::: : .:: :: ::..:. .: : NP_003 LEEMPCVGSCQLLLNKFWGWLN-FPLFFVPCLIMISLYVKIFVVATRQAQQITTLSKSLA 190 200 210 220 230 240 230 240 250 260 270 280 pF1KB7 AATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSAL .:. .:.::. ::. ..: ...::.:. . .: . :.. : .:..: ::: NP_003 GAAKHERKAAKTLGIAVGIYLLCWLPFTIDTMVDSLLHFITPPLVFD-IFIWFAYFNSAC 250 260 270 280 290 300 290 300 310 320 330 340 pF1KB7 NPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQ :::.:. . :: NP_003 NPIIYVFSYQWFRKALKLTLSQKVFSPQTRTVDLYQE 310 320 330 >>NP_000785 (OMIM: 126449) D(1A) dopamine receptor [Homo (446 aa) initn: 448 init1: 270 opt: 522 Z-score: 523.4 bits: 105.9 E(85289): 2.1e-22 Smith-Waterman score: 689; 35.1% identity (64.7% similar) in 368 aa overlap (18-342:23-387) 10 20 30 40 50 pF1KB7 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRN-LTN .: . :..::: :. ::..:: :: :.::. .:: NP_000 MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 CFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISL :..:::..:::...::.:..:. ... : ::. ::::....:.: ::::::: .::. NP_000 FFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGS-FCNIWVAFDIMCSTASILNLCVISV 70 80 90 100 110 120 130 140 150 160 170 pF1KB7 DRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSK--GNHTT- ::: :. .:.:: .:: . : . . :..:. .::. ..:.:.. . :: :: :. NP_000 DRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSL 120 130 140 150 160 170 180 190 200 210 pF1KB7 ----SKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHI-------- ..: .....:.. .....::.:. :: .:: ::...:. : .:: . NP_000 AETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAK 180 190 200 210 220 230 220 230 240 250 pF1KB7 ------------------SSWKAATIREHKATVTLAAVMGAFIICWFPYFT-----AFVY ::.: . :: :. ::...::.:. ::.:.: : NP_000 NCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCG 240 250 260 270 280 290 260 270 280 290 300 310 pF1KB7 RGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCC-RL--ANRNSH : :. . .:.:.:::.::::.:: .: ::: ... :. : :: :. :. NP_000 SGETQPFCIDSNTFDVFVWFGWANSSLNPIIYA-FNADFRKAFSTLLGCYRLCPATNNAI 300 310 320 330 340 350 320 330 340 350 360 370 pF1KB7 KT-SLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDRPWLCLPECWSVEL .: :. .:.. . .. .::: . : .: NP_000 ETVSINNNGAAMFSSH-HEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLS 360 370 380 390 400 410 397 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 17:02:02 2016 done: Sun Nov 6 17:02:04 2016 Total Scan time: 6.970 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]