FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2528, 449 aa 1>>>pF1KE2528 449 - 449 aa - 449 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9492+/-0.00032; mu= 20.0629+/- 0.020 mean_var=65.0512+/-13.117, 0's: 0 Z-trim(115.9): 160 B-trim: 177 in 2/50 Lambda= 0.159018 statistics sampled from 26536 (26702) to 26536 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.669), E-opt: 0.2 (0.313), width: 16 Scan time: 6.430 The best scores are: opt bits E(85289) NP_000162 (OMIM: 138491,149400) glycine receptor s ( 449) 3026 702.8 4.7e-202 NP_001139512 (OMIM: 138491,149400) glycine recepto ( 457) 3000 696.8 3e-200 XP_016864838 (OMIM: 138491,149400) PREDICTED: glyc ( 465) 2907 675.5 8e-194 NP_001036008 (OMIM: 600421) glycine receptor subun ( 449) 2523 587.4 2.6e-167 NP_001278929 (OMIM: 138491,149400) glycine recepto ( 366) 2478 577.0 2.8e-164 NP_006520 (OMIM: 600421) glycine receptor subunit ( 464) 2387 556.2 6.5e-158 XP_016884916 (OMIM: 305990) PREDICTED: glycine rec ( 452) 2337 544.7 1.8e-154 NP_001112358 (OMIM: 305990) glycine receptor subun ( 452) 2337 544.7 1.8e-154 NP_002054 (OMIM: 305990) glycine receptor subunit ( 452) 2331 543.4 4.7e-154 NP_001112357 (OMIM: 305990) glycine receptor subun ( 452) 2331 543.4 4.7e-154 XP_011543798 (OMIM: 305990) PREDICTED: glycine rec ( 436) 2328 542.7 7.3e-154 XP_006724550 (OMIM: 305990) PREDICTED: glycine rec ( 436) 2328 542.7 7.3e-154 XP_011543797 (OMIM: 305990) PREDICTED: glycine rec ( 436) 2328 542.7 7.3e-154 XP_016864119 (OMIM: 600421) PREDICTED: glycine rec ( 424) 2299 536.0 7.2e-152 XP_016884918 (OMIM: 305990) PREDICTED: glycine rec ( 363) 2008 469.2 8e-132 NP_001165413 (OMIM: 305990) glycine receptor subun ( 363) 2008 469.2 8e-132 XP_016884917 (OMIM: 305990) PREDICTED: glycine rec ( 363) 2008 469.2 8e-132 XP_011530569 (OMIM: 600421) PREDICTED: glycine rec ( 313) 1825 427.2 3.1e-119 XP_011530570 (OMIM: 600421) PREDICTED: glycine rec ( 269) 1277 301.4 1.9e-81 NP_000815 (OMIM: 138492,614619) glycine receptor s ( 497) 1170 277.0 7.6e-74 NP_001159532 (OMIM: 138492,614619) glycine recepto ( 497) 1170 277.0 7.6e-74 XP_016863523 (OMIM: 138492,614619) PREDICTED: glyc ( 399) 991 235.9 1.5e-61 XP_016863524 (OMIM: 138492,614619) PREDICTED: glyc ( 303) 987 234.9 2.2e-61 NP_001159533 (OMIM: 138492,614619) glycine recepto ( 303) 987 234.9 2.2e-61 XP_016863472 (OMIM: 103780,137140) PREDICTED: gamm ( 451) 983 234.1 5.8e-61 NP_000798 (OMIM: 103780,137140) gamma-aminobutyric ( 451) 983 234.1 5.8e-61 XP_016863471 (OMIM: 103780,137140) PREDICTED: gamm ( 451) 983 234.1 5.8e-61 NP_001107647 (OMIM: 103780,137140) gamma-aminobuty ( 451) 983 234.1 5.8e-61 NP_001121115 (OMIM: 137160,611136,615744) gamma-am ( 456) 954 227.5 5.9e-59 NP_000797 (OMIM: 137160,611136,615744) gamma-amino ( 456) 954 227.5 5.9e-59 NP_001121117 (OMIM: 137160,611136,615744) gamma-am ( 456) 954 227.5 5.9e-59 NP_001121116 (OMIM: 137160,611136,615744) gamma-am ( 456) 954 227.5 5.9e-59 NP_001121120 (OMIM: 137160,611136,615744) gamma-am ( 456) 954 227.5 5.9e-59 NP_000804 (OMIM: 600232) gamma-aminobutyric acid r ( 474) 943 224.9 3.5e-58 NP_068711 (OMIM: 600232) gamma-aminobutyric acid r ( 512) 940 224.3 6e-58 NP_068712 (OMIM: 137192,612269,617113) gamma-amino ( 473) 938 223.8 7.7e-58 XP_006720522 (OMIM: 137142) PREDICTED: gamma-amino ( 462) 936 223.3 1e-57 XP_005268315 (OMIM: 137142) PREDICTED: gamma-amino ( 462) 936 223.3 1e-57 NP_000801 (OMIM: 137142) gamma-aminobutyric acid r ( 462) 936 223.3 1e-57 NP_001158509 (OMIM: 137142) gamma-aminobutyric aci ( 462) 936 223.3 1e-57 NP_000805 (OMIM: 137192,612269,617113) gamma-amino ( 473) 935 223.1 1.2e-57 NP_000803 (OMIM: 137190,617153) gamma-aminobutyric ( 474) 935 223.1 1.2e-57 NP_055026 (OMIM: 602729) gamma-aminobutyric acid r ( 440) 927 221.3 4.2e-57 NP_000806 (OMIM: 137163,613060) gamma-aminobutyric ( 452) 927 221.3 4.3e-57 XP_011539496 (OMIM: 137163,613060) PREDICTED: gamm ( 465) 927 221.3 4.4e-57 XP_016856425 (OMIM: 137163,613060) PREDICTED: gamm ( 687) 927 221.4 6e-57 NP_001243632 (OMIM: 137161) gamma-aminobutyric aci ( 462) 920 219.7 1.3e-56 NP_002033 (OMIM: 137161) gamma-aminobutyric acid r ( 479) 920 219.7 1.4e-56 NP_775807 (OMIM: 137166) gamma-aminobutyric acid r ( 465) 910 217.4 6.5e-56 NP_000807 (OMIM: 137164,607681,611277) gamma-amino ( 467) 905 216.2 1.5e-55 >>NP_000162 (OMIM: 138491,149400) glycine receptor subun (449 aa) initn: 3026 init1: 3026 opt: 3026 Z-score: 3748.5 bits: 702.8 E(85289): 4.7e-202 Smith-Waterman score: 3026; 100.0% identity (100.0% similar) in 449 aa overlap (1-449:1-449) 10 20 30 40 50 60 pF1KE2 MYSFNTLRLYLWETIVFFSLAASKEAEAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MYSFNTLRLYLWETIVFFSLAASKEAEAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 KGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 KGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 IWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 IWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 IMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 IMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 RFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 RFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 SLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKEDEAGEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 SLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKEDEAGEG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 RFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQRAKKIDKISR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 RFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQRAKKIDKISR 370 380 390 400 410 420 430 440 pF1KE2 IGFPMAFLIFNMFYWIIYKIVRREDVHNQ ::::::::::::::::::::::::::::: NP_000 IGFPMAFLIFNMFYWIIYKIVRREDVHNQ 430 440 >>NP_001139512 (OMIM: 138491,149400) glycine receptor su (457 aa) initn: 2371 init1: 2371 opt: 3000 Z-score: 3716.2 bits: 696.8 E(85289): 3e-200 Smith-Waterman score: 3000; 98.2% identity (98.2% similar) in 457 aa overlap (1-449:1-457) 10 20 30 40 50 60 pF1KE2 MYSFNTLRLYLWETIVFFSLAASKEAEAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MYSFNTLRLYLWETIVFFSLAASKEAEAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 KGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 IWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 IMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 RFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRA 250 260 270 280 290 300 310 320 330 340 350 pF1KE2 SLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHK------- ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKSPMLNLF 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE2 -EDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQRA ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQRA 370 380 390 400 410 420 420 430 440 pF1KE2 KKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ ::::::::::::::::::::::::::::::::::::: NP_001 KKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ 430 440 450 >>XP_016864838 (OMIM: 138491,149400) PREDICTED: glycine (465 aa) initn: 2907 init1: 2907 opt: 2907 Z-score: 3600.8 bits: 675.5 E(85289): 8e-194 Smith-Waterman score: 2907; 99.1% identity (99.8% similar) in 435 aa overlap (15-449:31-465) 10 20 30 40 pF1KE2 MYSFNTLRLYLWETIVFFSLAASKEAEAARSAPKPMSPSDFLDK . ..:::::::::::::::::::::::::: XP_016 MGIQPNLEPTLIKGNLYQHEKEPSLTFCSPLFLLSLAASKEAEAARSAPKPMSPSDFLDK 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE2 LMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYN 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE2 EYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTL 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE2 ACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLR 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE2 YCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLG 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE2 ITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLR 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE2 FRRKRRHHKEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FRRKRRHHKEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEM 370 380 390 400 410 420 410 420 430 440 pF1KE2 RKLFIQRAKKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ ::::::::::::::::::::::::::::::::::::::::::::: XP_016 RKLFIQRAKKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ 430 440 450 460 >>NP_001036008 (OMIM: 600421) glycine receptor subunit a (449 aa) initn: 2454 init1: 2111 opt: 2523 Z-score: 3124.9 bits: 587.4 E(85289): 2.6e-167 Smith-Waterman score: 2523; 83.9% identity (94.8% similar) in 441 aa overlap (9-449:14-447) 10 20 30 40 50 pF1KE2 MYSFNTLRLYLWETIVFFSLAASKEAEAARSAPKPMSPSDFLDKLMGRTSGYDAR .:.::. ...::.:.::...::: ::::::::::::::::::::: NP_001 MAHVRHFRTLVSGFYFWEAALLLSLVATKETDSARSRSAPMSPSDFLDKLMGRTSGYDAR 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 IRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDP ::::::::::::.::::::::::::::::::::::::::.::::::::.::::::::::: NP_001 IRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDP 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 SMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPM :::::::::::::::::::.:::.::::::::: .:::::::::.::::.:::::::::: NP_001 SMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPM 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE2 DVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKF ::::::::::::::::::::::::... ::::.:::::::.::::::::::::::::::: NP_001 DVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKF 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE2 TCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQS ::::.:::::::::::::::::::::::::::.:::::::::::::.::::::::::::: NP_001 TCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQS 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE2 SGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKED ::::::::::::::::::::::::::::::::::::::::::::::::::::::.. :.: NP_001 SGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRKN-KDD 310 320 330 340 350 360 370 380 390 400 410 pF1KE2 EAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQRAKKI :. :.::.:.:::::: :::::::.. :: :. . : :::.::::.::.::::: NP_001 EVRESRFSFTAYGMGP-CLQAKDGMTPKGPNHPVQVMP-----KSPDEMRKVFIDRAKKI 360 370 380 390 400 410 420 430 440 pF1KE2 DKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ : ::: ::.::::::.:::.::::.:.::.:.: NP_001 DTISRACFPLAFLIFNIFYWVIYKILRHEDIHQQQD 420 430 440 >>NP_001278929 (OMIM: 138491,149400) glycine receptor su (366 aa) initn: 2478 init1: 2478 opt: 2478 Z-score: 3070.3 bits: 577.0 E(85289): 2.8e-164 Smith-Waterman score: 2478; 100.0% identity (100.0% similar) in 366 aa overlap (84-449:1-366) 60 70 80 90 100 110 pF1KE2 ARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDL :::::::::::::::::::::::::::::: NP_001 MDYRVNIFLRQQWNDPRLAYNEYPDDSLDL 10 20 30 120 130 140 150 160 170 pF1KE2 DPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNF 40 50 60 70 80 90 180 190 200 210 220 230 pF1KE2 PMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTG 100 110 120 130 140 150 240 250 260 270 280 290 pF1KE2 KFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTT 160 170 180 190 200 210 300 310 320 330 340 350 pF1KE2 QSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHK 220 230 240 250 260 270 360 370 380 390 400 410 pF1KE2 EDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQRAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQRAK 280 290 300 310 320 330 420 430 440 pF1KE2 KIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ :::::::::::::::::::::::::::::::::::: NP_001 KIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ 340 350 360 >>NP_006520 (OMIM: 600421) glycine receptor subunit alph (464 aa) initn: 2457 init1: 2136 opt: 2387 Z-score: 2956.0 bits: 556.2 E(85289): 6.5e-158 Smith-Waterman score: 2494; 81.3% identity (91.9% similar) in 455 aa overlap (9-449:14-462) 10 20 30 40 50 pF1KE2 MYSFNTLRLYLWETIVFFSLAASKEAEAARSAPKPMSPSDFLDKLMGRTSGYDAR .:.::. ...::.:.::...::: ::::::::::::::::::::: NP_006 MAHVRHFRTLVSGFYFWEAALLLSLVATKETDSARSRSAPMSPSDFLDKLMGRTSGYDAR 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 IRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDP ::::::::::::.::::::::::::::::::::::::::.::::::::.::::::::::: NP_006 IRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDP 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 SMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPM :::::::::::::::::::.:::.::::::::: .:::::::::.::::.:::::::::: NP_006 SMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPM 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE2 DVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKF ::::::::::::::::::::::::... ::::.:::::::.::::::::::::::::::: NP_006 DVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKF 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE2 TCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQS ::::.:::::::::::::::::::::::::::.:::::::::::::.::::::::::::: NP_006 TCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQS 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE2 SGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKE- ::::::::::::::::::::::::::::::::::::::::::::::::::::::... : NP_006 SGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRKNKTEA 310 320 330 340 350 360 360 370 380 390 400 pF1KE2 -------------DEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSP ::. :.::.:.:::::: :::::::.. :: :. . : ::: NP_006 FALEKFYRFSDMDDEVRESRFSFTAYGMGP-CLQAKDGMTPKGPNHPVQVMP-----KSP 370 380 390 400 410 410 420 430 440 pF1KE2 EEMRKLFIQRAKKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ .::::.::.:::::: ::: ::.::::::.:::.::::.:.::.:.: NP_006 DEMRKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIYKILRHEDIHQQQD 420 430 440 450 460 >>XP_016884916 (OMIM: 305990) PREDICTED: glycine recepto (452 aa) initn: 2236 init1: 1988 opt: 2337 Z-score: 2894.2 bits: 544.7 E(85289): 1.8e-154 Smith-Waterman score: 2337; 79.9% identity (91.5% similar) in 437 aa overlap (18-449:22-452) 10 20 30 40 50 pF1KE2 MYSFNTLRLYLWETIVFFSLAASKEAEAARSAPKP---MSPSDFLDKLMGRTSGYD : : :. .. ::. .: .::::::::::::::::: XP_016 MNRQLVNILTALFAFFLETNHFRTAFCKDHDS-RSGKQPSQTLSPSDFLDKLMGRTSGYD 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 ARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDL ::::::::::::::.:::::::::::::::::::::::::::::: ::::.::::::::: XP_016 ARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDL 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 DPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNF :::::::::::::::::::::.::..::::::::::.::.::::::.::::.:::::::: XP_016 DPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNF 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE2 PMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTG ::::::: ::::::::::::::::: .: ::::.:::::::::::::.: ::::::::: XP_016 PMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTG 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE2 KFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTT ::::::..::::::::::::::::::::::::::.:::::::::::::.::::::::::: XP_016 KFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTT 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE2 QSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRR--KRRH ::::::::::::::::::::::::::::::.:::::::::::::::::.::.:: ::.. XP_016 QSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQN 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE2 HKEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQR ..:: . :.:::::.:::: :::.::: .:: .. .:: : : :. . ..: :..: XP_016 KEEDVTRESRFNFSGYGMGH-CLQVKDGTAVK----ATPANPLPQPPKDGDAIKKKFVDR 360 370 380 390 400 410 420 430 440 pF1KE2 AKKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ ::.:: ::: .::.::::::.:::: :::.:.::::.. XP_016 AKRIDTISRAAFPLAFLIFNIFYWITYKIIRHEDVHKK 420 430 440 450 >>NP_001112358 (OMIM: 305990) glycine receptor subunit a (452 aa) initn: 2236 init1: 1988 opt: 2337 Z-score: 2894.2 bits: 544.7 E(85289): 1.8e-154 Smith-Waterman score: 2337; 79.9% identity (91.5% similar) in 437 aa overlap (18-449:22-452) 10 20 30 40 50 pF1KE2 MYSFNTLRLYLWETIVFFSLAASKEAEAARSAPKP---MSPSDFLDKLMGRTSGYD : : :. .. ::. .: .::::::::::::::::: NP_001 MNRQLVNILTALFAFFLETNHFRTAFCKDHDS-RSGKQPSQTLSPSDFLDKLMGRTSGYD 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 ARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDL ::::::::::::::.:::::::::::::::::::::::::::::: ::::.::::::::: NP_001 ARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDL 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 DPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNF :::::::::::::::::::::.::..::::::::::.::.::::::.::::.:::::::: NP_001 DPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNF 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE2 PMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTG ::::::: ::::::::::::::::: .: ::::.:::::::::::::.: ::::::::: NP_001 PMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTG 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE2 KFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTT ::::::..::::::::::::::::::::::::::.:::::::::::::.::::::::::: NP_001 KFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTT 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE2 QSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRR--KRRH ::::::::::::::::::::::::::::::.:::::::::::::::::.::.:: ::.. NP_001 QSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQN 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE2 HKEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQR ..:: . :.:::::.:::: :::.::: .:: .. .:: : : :. . ..: :..: NP_001 KEEDVTRESRFNFSGYGMGH-CLQVKDGTAVK----ATPANPLPQPPKDGDAIKKKFVDR 360 370 380 390 400 410 420 430 440 pF1KE2 AKKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ ::.:: ::: .::.::::::.:::: :::.:.::::.. NP_001 AKRIDTISRAAFPLAFLIFNIFYWITYKIIRHEDVHKK 420 430 440 450 >>NP_002054 (OMIM: 305990) glycine receptor subunit alph (452 aa) initn: 2230 init1: 1982 opt: 2331 Z-score: 2886.8 bits: 543.4 E(85289): 4.7e-154 Smith-Waterman score: 2331; 79.4% identity (91.5% similar) in 437 aa overlap (18-449:22-452) 10 20 30 40 50 pF1KE2 MYSFNTLRLYLWETIVFFSLAASKEAEAARSAPKP---MSPSDFLDKLMGRTSGYD : : :. .. ::. .: .::::::::::::::::: NP_002 MNRQLVNILTALFAFFLETNHFRTAFCKDHDS-RSGKQPSQTLSPSDFLDKLMGRTSGYD 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 ARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDL ::::::::::::::.::::::::::..:::::::::::::::::: ::::.::::::::: NP_002 ARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDL 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 DPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNF :::::::::::::::::::::.::..::::::::::.::.::::::.::::.:::::::: NP_002 DPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNF 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE2 PMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTG ::::::: ::::::::::::::::: .: ::::.:::::::::::::.: ::::::::: NP_002 PMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTG 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE2 KFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTT ::::::..::::::::::::::::::::::::::.:::::::::::::.::::::::::: NP_002 KFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTT 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE2 QSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRR--KRRH ::::::::::::::::::::::::::::::.:::::::::::::::::.::.:: ::.. NP_002 QSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQN 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE2 HKEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQR ..:: . :.:::::.:::: :::.::: .:: .. .:: : : :. . ..: :..: NP_002 KEEDVTRESRFNFSGYGMGH-CLQVKDGTAVK----ATPANPLPQPPKDGDAIKKKFVDR 360 370 380 390 400 410 420 430 440 pF1KE2 AKKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ ::.:: ::: .::.::::::.:::: :::.:.::::.. NP_002 AKRIDTISRAAFPLAFLIFNIFYWITYKIIRHEDVHKK 420 430 440 450 >>NP_001112357 (OMIM: 305990) glycine receptor subunit a (452 aa) initn: 2230 init1: 1982 opt: 2331 Z-score: 2886.8 bits: 543.4 E(85289): 4.7e-154 Smith-Waterman score: 2331; 79.4% identity (91.5% similar) in 437 aa overlap (18-449:22-452) 10 20 30 40 50 pF1KE2 MYSFNTLRLYLWETIVFFSLAASKEAEAARSAPKP---MSPSDFLDKLMGRTSGYD : : :. .. ::. .: .::::::::::::::::: NP_001 MNRQLVNILTALFAFFLETNHFRTAFCKDHDS-RSGKQPSQTLSPSDFLDKLMGRTSGYD 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 ARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDL ::::::::::::::.::::::::::..:::::::::::::::::: ::::.::::::::: NP_001 ARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDL 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 DPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNF :::::::::::::::::::::.::..::::::::::.::.::::::.::::.:::::::: NP_001 DPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNF 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE2 PMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTG ::::::: ::::::::::::::::: .: ::::.:::::::::::::.: ::::::::: NP_001 PMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTG 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE2 KFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTT ::::::..::::::::::::::::::::::::::.:::::::::::::.::::::::::: NP_001 KFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTT 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE2 QSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRR--KRRH ::::::::::::::::::::::::::::::.:::::::::::::::::.::.:: ::.. NP_001 QSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQN 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE2 HKEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQR ..:: . :.:::::.:::: :::.::: .:: .. .:: : : :. . ..: :..: NP_001 KEEDVTRESRFNFSGYGMGH-CLQVKDGTAVK----ATPANPLPQPPKDGDAIKKKFVDR 360 370 380 390 400 410 420 430 440 pF1KE2 AKKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ ::.:: ::: .::.::::::.:::: :::.:.::::.. NP_001 AKRIDTISRAAFPLAFLIFNIFYWITYKIIRHEDVHKK 420 430 440 450 449 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 03:28:02 2016 done: Tue Nov 8 03:28:03 2016 Total Scan time: 6.430 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]