FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2050, 671 aa 1>>>pF1KE2050 671 - 671 aa - 671 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.6870+/-0.000363; mu= 4.3958+/- 0.023 mean_var=167.2606+/-33.517, 0's: 0 Z-trim(118.5): 4 B-trim: 0 in 0/58 Lambda= 0.099169 statistics sampled from 31492 (31495) to 31492 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.707), E-opt: 0.2 (0.369), width: 16 Scan time: 12.530 The best scores are: opt bits E(85289) NP_008878 (OMIM: 602122,614675) signal recognition ( 671) 4351 634.8 3e-181 XP_005265822 (OMIM: 602122,614675) PREDICTED: sign ( 663) 3511 514.7 4.5e-145 NP_001254651 (OMIM: 602122,614675) signal recognit ( 610) 2578 381.2 6.4e-105 >>NP_008878 (OMIM: 602122,614675) signal recognition par (671 aa) initn: 4351 init1: 4351 opt: 4351 Z-score: 3374.9 bits: 634.8 E(85289): 3e-181 Smith-Waterman score: 4351; 100.0% identity (100.0% similar) in 671 aa overlap (1-671:1-671) 10 20 30 40 50 60 pF1KE2 MASGGSGGVSVPALWSEVNRYGQNGDFTRALKTVNKILQINKDDVTALHCKVVCLIQNGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 MASGGSGGVSVPALWSEVNRYGQNGDFTRALKTVNKILQINKDDVTALHCKVVCLIQNGS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 FKEALNVINTHTKVLANNSLSFEKAYCEYRLNRIENALKTIESANQQTDKLKELYGQVLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 FKEALNVINTHTKVLANNSLSFEKAYCEYRLNRIENALKTIESANQQTDKLKELYGQVLY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 RLERYDECLAVYRDLVRNSQDDYDEERKTNLSAVVAAQSNWEKVVPENLGLQEGTHELCY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 RLERYDECLAVYRDLVRNSQDDYDEERKTNLSAVVAAQSNWEKVVPENLGLQEGTHELCY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 NTACALIGQGQLNQAMKILQKAEDLCRRSLSEDTDGTEEDPQAELAIIHGQMAYILQLQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 NTACALIGQGQLNQAMKILQKAEDLCRRSLSEDTDGTEEDPQAELAIIHGQMAYILQLQG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 RTEEALQLYNQIIKLKPTDVGLLAVIANNIITINKDQNVFDSKKKVKLTNAEGVEFKLSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 RTEEALQLYNQIIKLKPTDVGLLAVIANNIITINKDQNVFDSKKKVKLTNAEGVEFKLSK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 KQLQAIEFNKALLAMYTNQAEQCRKISASLQSQSPEHLLPVLIQAAQLCREKQHTKAIEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 KQLQAIEFNKALLAMYTNQAEQCRKISASLQSQSPEHLLPVLIQAAQLCREKQHTKAIEL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 LQEFSDQHPENAAEIKLTMAQLKISQGNISKACLILRSIEELKHKPGMVSALVTMYSHEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 LQEFSDQHPENAAEIKLTMAQLKISQGNISKACLILRSIEELKHKPGMVSALVTMYSHEE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 DIDSAIEVFTQAIQWYQNHQPKSPAHLSLIREAANFKLKYGRKKEAISDLQQLWKQNPKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 DIDSAIEVFTQAIQWYQNHQPKSPAHLSLIREAANFKLKYGRKKEAISDLQQLWKQNPKD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 IHTLAQLISAYSLVDPEKAKALSKHLPSSDSMSLKVDVEALENSAGATYIRKKGGKVTGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 IHTLAQLISAYSLVDPEKAKALSKHLPSSDSMSLKVDVEALENSAGATYIRKKGGKVTGD 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 SQPKEQGQGDLKKKKKKKKGKLPKNYDPKVTPDPERWLPMRERSYYRGRKKGKKKDQIGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 SQPKEQGQGDLKKKKKKKKGKLPKNYDPKVTPDPERWLPMRERSYYRGRKKGKKKDQIGK 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 GTQGATAGASSELDASKTVSSPPTSPRPGSAATVSASTSNIIPPRHQKPAGAPATKKKQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 GTQGATAGASSELDASKTVSSPPTSPRPGSAATVSASTSNIIPPRHQKPAGAPATKKKQQ 610 620 630 640 650 660 670 pF1KE2 QKKKKGGKGGW ::::::::::: NP_008 QKKKKGGKGGW 670 >>XP_005265822 (OMIM: 602122,614675) PREDICTED: signal r (663 aa) initn: 3511 init1: 3511 opt: 3511 Z-score: 2725.5 bits: 514.7 E(85289): 4.5e-145 Smith-Waterman score: 3511; 100.0% identity (100.0% similar) in 547 aa overlap (1-547:116-662) 10 20 30 pF1KE2 MASGGSGGVSVPALWSEVNRYGQNGDFTRA :::::::::::::::::::::::::::::: XP_005 AIIDFLLLLAASEILFRGRGLPAPPLVSSKMASGGSGGVSVPALWSEVNRYGQNGDFTRA 90 100 110 120 130 140 40 50 60 70 80 90 pF1KE2 LKTVNKILQINKDDVTALHCKVVCLIQNGSFKEALNVINTHTKVLANNSLSFEKAYCEYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LKTVNKILQINKDDVTALHCKVVCLIQNGSFKEALNVINTHTKVLANNSLSFEKAYCEYR 150 160 170 180 190 200 100 110 120 130 140 150 pF1KE2 LNRIENALKTIESANQQTDKLKELYGQVLYRLERYDECLAVYRDLVRNSQDDYDEERKTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LNRIENALKTIESANQQTDKLKELYGQVLYRLERYDECLAVYRDLVRNSQDDYDEERKTN 210 220 230 240 250 260 160 170 180 190 200 210 pF1KE2 LSAVVAAQSNWEKVVPENLGLQEGTHELCYNTACALIGQGQLNQAMKILQKAEDLCRRSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LSAVVAAQSNWEKVVPENLGLQEGTHELCYNTACALIGQGQLNQAMKILQKAEDLCRRSL 270 280 290 300 310 320 220 230 240 250 260 270 pF1KE2 SEDTDGTEEDPQAELAIIHGQMAYILQLQGRTEEALQLYNQIIKLKPTDVGLLAVIANNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SEDTDGTEEDPQAELAIIHGQMAYILQLQGRTEEALQLYNQIIKLKPTDVGLLAVIANNI 330 340 350 360 370 380 280 290 300 310 320 330 pF1KE2 ITINKDQNVFDSKKKVKLTNAEGVEFKLSKKQLQAIEFNKALLAMYTNQAEQCRKISASL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ITINKDQNVFDSKKKVKLTNAEGVEFKLSKKQLQAIEFNKALLAMYTNQAEQCRKISASL 390 400 410 420 430 440 340 350 360 370 380 390 pF1KE2 QSQSPEHLLPVLIQAAQLCREKQHTKAIELLQEFSDQHPENAAEIKLTMAQLKISQGNIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QSQSPEHLLPVLIQAAQLCREKQHTKAIELLQEFSDQHPENAAEIKLTMAQLKISQGNIS 450 460 470 480 490 500 400 410 420 430 440 450 pF1KE2 KACLILRSIEELKHKPGMVSALVTMYSHEEDIDSAIEVFTQAIQWYQNHQPKSPAHLSLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KACLILRSIEELKHKPGMVSALVTMYSHEEDIDSAIEVFTQAIQWYQNHQPKSPAHLSLI 510 520 530 540 550 560 460 470 480 490 500 510 pF1KE2 REAANFKLKYGRKKEAISDLQQLWKQNPKDIHTLAQLISAYSLVDPEKAKALSKHLPSSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 REAANFKLKYGRKKEAISDLQQLWKQNPKDIHTLAQLISAYSLVDPEKAKALSKHLPSSD 570 580 590 600 610 620 520 530 540 550 560 570 pF1KE2 SMSLKVDVEALENSAGATYIRKKGGKVTGDSQPKEQGQGDLKKKKKKKKGKLPKNYDPKV ::::::::::::::::::::::::::::::::::::: XP_005 SMSLKVDVEALENSAGATYIRKKGGKVTGDSQPKEQGA 630 640 650 660 580 590 600 610 620 630 pF1KE2 TPDPERWLPMRERSYYRGRKKGKKKDQIGKGTQGATAGASSELDASKTVSSPPTSPRPGS >>NP_001254651 (OMIM: 602122,614675) signal recognition (610 aa) initn: 2578 init1: 2578 opt: 2578 Z-score: 2004.7 bits: 381.2 E(85289): 6.4e-105 Smith-Waterman score: 3840; 90.9% identity (90.9% similar) in 671 aa overlap (1-671:1-610) 10 20 30 40 50 60 pF1KE2 MASGGSGGVSVPALWSEVNRYGQNGDFTRALKTVNKILQINKDDVTALHCKVVCLIQNGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MASGGSGGVSVPALWSEVNRYGQNGDFTRALKTVNKILQINKDDVTALHCKVVCLIQNGS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 FKEALNVINTHTKVLANNSLSFEKAYCEYRLNRIENALKTIESANQQTDKLKELYGQVLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FKEALNVINTHTKVLANNSLSFEKAYCEYRLNRIENALKTIESANQQTDKLKELYGQVLY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 RLERYDECLAVYRDLVRNSQDDYDEERKTNLSAVVAAQSNWEKVVPENLGLQEGTHELCY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLERYDECLAVYRDLVRNSQDDYDEERKTNLSAVVAAQSNWEKVVPENLGLQEGTHELCY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 NTACALIGQGQLNQAMKILQKAEDLCRRSLSEDTDGTEEDPQAELAIIHGQMAYILQLQG ::::::::::::::::::::::::::::::::::: NP_001 NTACALIGQGQLNQAMKILQKAEDLCRRSLSEDTD------------------------- 190 200 210 250 260 270 280 290 300 pF1KE2 RTEEALQLYNQIIKLKPTDVGLLAVIANNIITINKDQNVFDSKKKVKLTNAEGVEFKLSK :::::::::::::::::::::::: NP_001 ------------------------------------QNVFDSKKKVKLTNAEGVEFKLSK 220 230 310 320 330 340 350 360 pF1KE2 KQLQAIEFNKALLAMYTNQAEQCRKISASLQSQSPEHLLPVLIQAAQLCREKQHTKAIEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KQLQAIEFNKALLAMYTNQAEQCRKISASLQSQSPEHLLPVLIQAAQLCREKQHTKAIEL 240 250 260 270 280 290 370 380 390 400 410 420 pF1KE2 LQEFSDQHPENAAEIKLTMAQLKISQGNISKACLILRSIEELKHKPGMVSALVTMYSHEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQEFSDQHPENAAEIKLTMAQLKISQGNISKACLILRSIEELKHKPGMVSALVTMYSHEE 300 310 320 330 340 350 430 440 450 460 470 480 pF1KE2 DIDSAIEVFTQAIQWYQNHQPKSPAHLSLIREAANFKLKYGRKKEAISDLQQLWKQNPKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DIDSAIEVFTQAIQWYQNHQPKSPAHLSLIREAANFKLKYGRKKEAISDLQQLWKQNPKD 360 370 380 390 400 410 490 500 510 520 530 540 pF1KE2 IHTLAQLISAYSLVDPEKAKALSKHLPSSDSMSLKVDVEALENSAGATYIRKKGGKVTGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IHTLAQLISAYSLVDPEKAKALSKHLPSSDSMSLKVDVEALENSAGATYIRKKGGKVTGD 420 430 440 450 460 470 550 560 570 580 590 600 pF1KE2 SQPKEQGQGDLKKKKKKKKGKLPKNYDPKVTPDPERWLPMRERSYYRGRKKGKKKDQIGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SQPKEQGQGDLKKKKKKKKGKLPKNYDPKVTPDPERWLPMRERSYYRGRKKGKKKDQIGK 480 490 500 510 520 530 610 620 630 640 650 660 pF1KE2 GTQGATAGASSELDASKTVSSPPTSPRPGSAATVSASTSNIIPPRHQKPAGAPATKKKQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GTQGATAGASSELDASKTVSSPPTSPRPGSAATVSASTSNIIPPRHQKPAGAPATKKKQQ 540 550 560 570 580 590 670 pF1KE2 QKKKKGGKGGW ::::::::::: NP_001 QKKKKGGKGGW 600 610 671 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 17:30:05 2016 done: Sun Nov 6 17:30:07 2016 Total Scan time: 12.530 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]