FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3142, 353 aa 1>>>pF1KE3142 353 - 353 aa - 353 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.2133+/-0.00036; mu= -5.8777+/- 0.022 mean_var=261.7932+/-54.509, 0's: 0 Z-trim(122.6): 12 B-trim: 1396 in 1/56 Lambda= 0.079267 statistics sampled from 41077 (41089) to 41077 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.794), E-opt: 0.2 (0.482), width: 16 Scan time: 9.530 The best scores are: opt bits E(85289) NP_001276927 (OMIM: 187950,600044) thrombopoietin ( 353) 2335 279.7 6.9e-75 NP_000451 (OMIM: 187950,600044) thrombopoietin iso ( 353) 2335 279.7 6.9e-75 NP_001276957 (OMIM: 187950,600044) thrombopoietin ( 353) 2335 279.7 6.9e-75 NP_001276932 (OMIM: 187950,600044) thrombopoietin ( 493) 2335 279.8 9.1e-75 NP_001171068 (OMIM: 187950,600044) thrombopoietin ( 349) 2285 273.9 3.6e-73 NP_001276951 (OMIM: 187950,600044) thrombopoietin ( 349) 2285 273.9 3.6e-73 NP_001276956 (OMIM: 187950,600044) thrombopoietin ( 286) 1035 130.9 3.3e-30 NP_001276926 (OMIM: 187950,600044) thrombopoietin ( 286) 1035 130.9 3.3e-30 XP_016862596 (OMIM: 187950,600044) PREDICTED: thro ( 422) 985 125.3 2.4e-28 NP_001171069 (OMIM: 187950,600044) thrombopoietin ( 319) 842 108.9 1.6e-23 NP_001276955 (OMIM: 187950,600044) thrombopoietin ( 319) 842 108.9 1.6e-23 >>NP_001276927 (OMIM: 187950,600044) thrombopoietin isof (353 aa) initn: 2335 init1: 2335 opt: 2335 Z-score: 1465.4 bits: 279.7 E(85289): 6.9e-75 Smith-Waterman score: 2335; 100.0% identity (100.0% similar) in 353 aa overlap (1-353:1-353) 10 20 30 40 50 60 pF1KE3 MELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 LLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 LLGALQSLLGTQLPPQGRTTAHKDPNAIFLSFQHLLRGKVRFLMLVGGSTLCVRRAPPTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLGALQSLLGTQLPPQGRTTAHKDPNAIFLSFQHLLRGKVRFLMLVGGSTLCVRRAPPTT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 AVPSRTSLVLTLNELPNRTSGLLETNFTASARTTGSGLLKWQQGFRAKIPGLLNQTSRSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVPSRTSLVLTLNELPNRTSGLLETNFTASARTTGSGLLKWQQGFRAKIPGLLNQTSRSL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 DQIPGYLNRIHELLNGTRGLFPGPSRRTLGAPDISSGTSDTGSLPPNLQPGYSPSPTHPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DQIPGYLNRIHELLNGTRGLFPGPSRRTLGAPDISSGTSDTGSLPPNLQPGYSPSPTHPP 250 260 270 280 290 300 310 320 330 340 350 pF1KE3 TGQYTLFPLPPTLPTPVVQLHPLLPDPSAPTPTPTSPLLNTSYTHSQNLSQEG ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGQYTLFPLPPTLPTPVVQLHPLLPDPSAPTPTPTSPLLNTSYTHSQNLSQEG 310 320 330 340 350 >>NP_000451 (OMIM: 187950,600044) thrombopoietin isoform (353 aa) initn: 2335 init1: 2335 opt: 2335 Z-score: 1465.4 bits: 279.7 E(85289): 6.9e-75 Smith-Waterman score: 2335; 100.0% identity (100.0% similar) in 353 aa overlap (1-353:1-353) 10 20 30 40 50 60 pF1KE3 MELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 LLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 LLGALQSLLGTQLPPQGRTTAHKDPNAIFLSFQHLLRGKVRFLMLVGGSTLCVRRAPPTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LLGALQSLLGTQLPPQGRTTAHKDPNAIFLSFQHLLRGKVRFLMLVGGSTLCVRRAPPTT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 AVPSRTSLVLTLNELPNRTSGLLETNFTASARTTGSGLLKWQQGFRAKIPGLLNQTSRSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 AVPSRTSLVLTLNELPNRTSGLLETNFTASARTTGSGLLKWQQGFRAKIPGLLNQTSRSL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 DQIPGYLNRIHELLNGTRGLFPGPSRRTLGAPDISSGTSDTGSLPPNLQPGYSPSPTHPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 DQIPGYLNRIHELLNGTRGLFPGPSRRTLGAPDISSGTSDTGSLPPNLQPGYSPSPTHPP 250 260 270 280 290 300 310 320 330 340 350 pF1KE3 TGQYTLFPLPPTLPTPVVQLHPLLPDPSAPTPTPTSPLLNTSYTHSQNLSQEG ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 TGQYTLFPLPPTLPTPVVQLHPLLPDPSAPTPTPTSPLLNTSYTHSQNLSQEG 310 320 330 340 350 >>NP_001276957 (OMIM: 187950,600044) thrombopoietin isof (353 aa) initn: 2335 init1: 2335 opt: 2335 Z-score: 1465.4 bits: 279.7 E(85289): 6.9e-75 Smith-Waterman score: 2335; 100.0% identity (100.0% similar) in 353 aa overlap (1-353:1-353) 10 20 30 40 50 60 pF1KE3 MELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 LLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 LLGALQSLLGTQLPPQGRTTAHKDPNAIFLSFQHLLRGKVRFLMLVGGSTLCVRRAPPTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLGALQSLLGTQLPPQGRTTAHKDPNAIFLSFQHLLRGKVRFLMLVGGSTLCVRRAPPTT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 AVPSRTSLVLTLNELPNRTSGLLETNFTASARTTGSGLLKWQQGFRAKIPGLLNQTSRSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVPSRTSLVLTLNELPNRTSGLLETNFTASARTTGSGLLKWQQGFRAKIPGLLNQTSRSL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 DQIPGYLNRIHELLNGTRGLFPGPSRRTLGAPDISSGTSDTGSLPPNLQPGYSPSPTHPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DQIPGYLNRIHELLNGTRGLFPGPSRRTLGAPDISSGTSDTGSLPPNLQPGYSPSPTHPP 250 260 270 280 290 300 310 320 330 340 350 pF1KE3 TGQYTLFPLPPTLPTPVVQLHPLLPDPSAPTPTPTSPLLNTSYTHSQNLSQEG ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGQYTLFPLPPTLPTPVVQLHPLLPDPSAPTPTPTSPLLNTSYTHSQNLSQEG 310 320 330 340 350 >>NP_001276932 (OMIM: 187950,600044) thrombopoietin isof (493 aa) initn: 2335 init1: 2335 opt: 2335 Z-score: 1463.3 bits: 279.8 E(85289): 9.1e-75 Smith-Waterman score: 2335; 100.0% identity (100.0% similar) in 353 aa overlap (1-353:141-493) 10 20 30 pF1KE3 MELTELLLVVMLLLTARLTLSSPAPPACDL :::::::::::::::::::::::::::::: NP_001 QEPKPPPWPQEGFRGEAPNREPRQPDTPARMELTELLLVVMLLLTARLTLSSPAPPACDL 120 130 140 150 160 170 40 50 60 70 80 90 pF1KE3 RVLSKLLRDSHVLHSRLSQCPEVHPLPTPVLLPAVDFSLGEWKTQMEETKAQDILGAVTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RVLSKLLRDSHVLHSRLSQCPEVHPLPTPVLLPAVDFSLGEWKTQMEETKAQDILGAVTL 180 190 200 210 220 230 100 110 120 130 140 150 pF1KE3 LLEGVMAARGQLGPTCLSSLLGQLSGQVRLLLGALQSLLGTQLPPQGRTTAHKDPNAIFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLEGVMAARGQLGPTCLSSLLGQLSGQVRLLLGALQSLLGTQLPPQGRTTAHKDPNAIFL 240 250 260 270 280 290 160 170 180 190 200 210 pF1KE3 SFQHLLRGKVRFLMLVGGSTLCVRRAPPTTAVPSRTSLVLTLNELPNRTSGLLETNFTAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SFQHLLRGKVRFLMLVGGSTLCVRRAPPTTAVPSRTSLVLTLNELPNRTSGLLETNFTAS 300 310 320 330 340 350 220 230 240 250 260 270 pF1KE3 ARTTGSGLLKWQQGFRAKIPGLLNQTSRSLDQIPGYLNRIHELLNGTRGLFPGPSRRTLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ARTTGSGLLKWQQGFRAKIPGLLNQTSRSLDQIPGYLNRIHELLNGTRGLFPGPSRRTLG 360 370 380 390 400 410 280 290 300 310 320 330 pF1KE3 APDISSGTSDTGSLPPNLQPGYSPSPTHPPTGQYTLFPLPPTLPTPVVQLHPLLPDPSAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 APDISSGTSDTGSLPPNLQPGYSPSPTHPPTGQYTLFPLPPTLPTPVVQLHPLLPDPSAP 420 430 440 450 460 470 340 350 pF1KE3 TPTPTSPLLNTSYTHSQNLSQEG ::::::::::::::::::::::: NP_001 TPTPTSPLLNTSYTHSQNLSQEG 480 490 >>NP_001171068 (OMIM: 187950,600044) thrombopoietin isof (349 aa) initn: 1486 init1: 1486 opt: 2285 Z-score: 1434.6 bits: 273.9 E(85289): 3.6e-73 Smith-Waterman score: 2285; 98.9% identity (98.9% similar) in 353 aa overlap (1-353:1-349) 10 20 30 40 50 60 pF1KE3 MELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 LLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 LLGALQSLLGTQLPPQGRTTAHKDPNAIFLSFQHLLRGKVRFLMLVGGSTLCVRRAPPTT :::::::::::: :::::::::::::::::::::::::::::::::::::::::::: NP_001 LLGALQSLLGTQ----GRTTAHKDPNAIFLSFQHLLRGKVRFLMLVGGSTLCVRRAPPTT 130 140 150 160 170 190 200 210 220 230 240 pF1KE3 AVPSRTSLVLTLNELPNRTSGLLETNFTASARTTGSGLLKWQQGFRAKIPGLLNQTSRSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVPSRTSLVLTLNELPNRTSGLLETNFTASARTTGSGLLKWQQGFRAKIPGLLNQTSRSL 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE3 DQIPGYLNRIHELLNGTRGLFPGPSRRTLGAPDISSGTSDTGSLPPNLQPGYSPSPTHPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DQIPGYLNRIHELLNGTRGLFPGPSRRTLGAPDISSGTSDTGSLPPNLQPGYSPSPTHPP 240 250 260 270 280 290 310 320 330 340 350 pF1KE3 TGQYTLFPLPPTLPTPVVQLHPLLPDPSAPTPTPTSPLLNTSYTHSQNLSQEG ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGQYTLFPLPPTLPTPVVQLHPLLPDPSAPTPTPTSPLLNTSYTHSQNLSQEG 300 310 320 330 340 >>NP_001276951 (OMIM: 187950,600044) thrombopoietin isof (349 aa) initn: 1486 init1: 1486 opt: 2285 Z-score: 1434.6 bits: 273.9 E(85289): 3.6e-73 Smith-Waterman score: 2285; 98.9% identity (98.9% similar) in 353 aa overlap (1-353:1-349) 10 20 30 40 50 60 pF1KE3 MELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 LLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 LLGALQSLLGTQLPPQGRTTAHKDPNAIFLSFQHLLRGKVRFLMLVGGSTLCVRRAPPTT :::::::::::: :::::::::::::::::::::::::::::::::::::::::::: NP_001 LLGALQSLLGTQ----GRTTAHKDPNAIFLSFQHLLRGKVRFLMLVGGSTLCVRRAPPTT 130 140 150 160 170 190 200 210 220 230 240 pF1KE3 AVPSRTSLVLTLNELPNRTSGLLETNFTASARTTGSGLLKWQQGFRAKIPGLLNQTSRSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVPSRTSLVLTLNELPNRTSGLLETNFTASARTTGSGLLKWQQGFRAKIPGLLNQTSRSL 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE3 DQIPGYLNRIHELLNGTRGLFPGPSRRTLGAPDISSGTSDTGSLPPNLQPGYSPSPTHPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DQIPGYLNRIHELLNGTRGLFPGPSRRTLGAPDISSGTSDTGSLPPNLQPGYSPSPTHPP 240 250 260 270 280 290 310 320 330 340 350 pF1KE3 TGQYTLFPLPPTLPTPVVQLHPLLPDPSAPTPTPTSPLLNTSYTHSQNLSQEG ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGQYTLFPLPPTLPTPVVQLHPLLPDPSAPTPTPTSPLLNTSYTHSQNLSQEG 300 310 320 330 340 >>NP_001276956 (OMIM: 187950,600044) thrombopoietin isof (286 aa) initn: 1070 init1: 1029 opt: 1035 Z-score: 663.3 bits: 130.9 E(85289): 3.3e-30 Smith-Waterman score: 1037; 62.3% identity (74.7% similar) in 308 aa overlap (1-300:1-284) 10 20 30 40 50 60 pF1KE3 MELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 LLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRL 70 80 90 100 110 120 130 140 150 160 170 pF1KE3 LLGALQSLLGTQLPPQGRTTAHKDPNAIFLSFQHLLRGKVRFLMLVGGSTLCVRR----- ::::::::::::::::::::::::::::::::::::::: . .:: . :. . NP_001 LLGALQSLLGTQLPPQGRTTAHKDPNAIFLSFQHLLRGKD--FWIVGDKLHCLSQNYWLW 130 140 150 160 170 180 190 200 210 220 230 pF1KE3 APPTTA-VPSRTSLVLTLN-ELPNRTSGLLETNFTASARTTGSGLLKWQQGFRAKIPGLL : ..: . :. : : ..:. . . : . .:: :.:.. . : NP_001 ASEVAAGIQSQDSWSAEPNLQVPGPNPRIPEQD----TRT-----LEWNSW---TLSWTL 180 190 200 210 220 240 250 260 270 280 290 pF1KE3 NQTSRSLDQIPG-YLNRIHELLNGTRGLFPGPSRRTLGAPDISSGTSDTGSLPPNLQPGY .: :: :: .: :.. : .:. : .. :. :: . . .:: . . .. NP_001 TQDPRS----PGHFLRNIRHRLPATQ-----PPAWIFSFPNPSSYWT-VYALPSSTHLAH 230 240 250 260 270 300 310 320 330 340 350 pF1KE3 SPSPTHPPTGQYTLFPLPPTLPTPVVQLHPLLPDPSAPTPTPTSPLLNTSYTHSQNLSQE .:. :: NP_001 PCGPAPPPAS 280 >>NP_001276926 (OMIM: 187950,600044) thrombopoietin isof (286 aa) initn: 1070 init1: 1029 opt: 1035 Z-score: 663.3 bits: 130.9 E(85289): 3.3e-30 Smith-Waterman score: 1037; 62.3% identity (74.7% similar) in 308 aa overlap (1-300:1-284) 10 20 30 40 50 60 pF1KE3 MELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 LLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRL 70 80 90 100 110 120 130 140 150 160 170 pF1KE3 LLGALQSLLGTQLPPQGRTTAHKDPNAIFLSFQHLLRGKVRFLMLVGGSTLCVRR----- ::::::::::::::::::::::::::::::::::::::: . .:: . :. . NP_001 LLGALQSLLGTQLPPQGRTTAHKDPNAIFLSFQHLLRGKD--FWIVGDKLHCLSQNYWLW 130 140 150 160 170 180 190 200 210 220 230 pF1KE3 APPTTA-VPSRTSLVLTLN-ELPNRTSGLLETNFTASARTTGSGLLKWQQGFRAKIPGLL : ..: . :. : : ..:. . . : . .:: :.:.. . : NP_001 ASEVAAGIQSQDSWSAEPNLQVPGPNPRIPEQD----TRT-----LEWNSW---TLSWTL 180 190 200 210 220 240 250 260 270 280 290 pF1KE3 NQTSRSLDQIPG-YLNRIHELLNGTRGLFPGPSRRTLGAPDISSGTSDTGSLPPNLQPGY .: :: :: .: :.. : .:. : .. :. :: . . .:: . . .. NP_001 TQDPRS----PGHFLRNIRHRLPATQ-----PPAWIFSFPNPSSYWT-VYALPSSTHLAH 230 240 250 260 270 300 310 320 330 340 350 pF1KE3 SPSPTHPPTGQYTLFPLPPTLPTPVVQLHPLLPDPSAPTPTPTSPLLNTSYTHSQNLSQE .:. :: NP_001 PCGPAPPPAS 280 >>XP_016862596 (OMIM: 187950,600044) PREDICTED: thrombop (422 aa) initn: 842 init1: 842 opt: 985 Z-score: 629.9 bits: 125.3 E(85289): 2.4e-28 Smith-Waterman score: 987; 61.0% identity (73.4% similar) in 308 aa overlap (1-300:141-420) 10 20 30 pF1KE3 MELTELLLVVMLLLTARLTLSSPAPPACDL :::::::::::::::::::::::::::::: XP_016 QEPKPPPWPQEGFRGEAPNREPRQPDTPARMELTELLLVVMLLLTARLTLSSPAPPACDL 120 130 140 150 160 170 40 50 60 70 80 90 pF1KE3 RVLSKLLRDSHVLHSRLSQCPEVHPLPTPVLLPAVDFSLGEWKTQMEETKAQDILGAVTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RVLSKLLRDSHVLHSRLSQCPEVHPLPTPVLLPAVDFSLGEWKTQMEETKAQDILGAVTL 180 190 200 210 220 230 100 110 120 130 140 150 pF1KE3 LLEGVMAARGQLGPTCLSSLLGQLSGQVRLLLGALQSLLGTQLPPQGRTTAHKDPNAIFL ::::::::::::::::::::::::::::::::::::::::: ::::::::::::::: XP_016 LLEGVMAARGQLGPTCLSSLLGQLSGQVRLLLGALQSLLGT----QGRTTAHKDPNAIFL 240 250 260 270 280 160 170 180 190 200 pF1KE3 SFQHLLRGKVRFLMLVGGSTLCVRR-----APPTTA-VPSRTSLVLTLN-ELPNRTSGLL ::::::::: . .:: . :. . : ..: . :. : : ..:. . . XP_016 SFQHLLRGKD--FWIVGDKLHCLSQNYWLWASEVAAGIQSQDSWSAEPNLQVPGPNPRIP 290 300 310 320 330 340 210 220 230 240 250 260 pF1KE3 ETNFTASARTTGSGLLKWQQGFRAKIPGLLNQTSRSLDQIPG-YLNRIHELLNGTRGLFP : . .:: :.:.. . :.: :: :: .: :.. : .:. XP_016 EQD----TRT-----LEWNSW---TLSWTLTQDPRS----PGHFLRNIRHRLPATQ---- 350 360 370 380 270 280 290 300 310 320 pF1KE3 GPSRRTLGAPDISSGTSDTGSLPPNLQPGYSPSPTHPPTGQYTLFPLPPTLPTPVVQLHP : .. :. :: . . .:: . . .. .:. :: XP_016 -PPAWIFSFPNPSSYWT-VYALPSSTHLAHPCGPAPPPAS 390 400 410 420 330 340 350 pF1KE3 LLPDPSAPTPTPTSPLLNTSYTHSQNLSQEG >>NP_001171069 (OMIM: 187950,600044) thrombopoietin isof (319 aa) initn: 867 init1: 842 opt: 842 Z-score: 543.3 bits: 108.9 E(85289): 1.6e-23 Smith-Waterman score: 850; 51.9% identity (65.8% similar) in 345 aa overlap (1-336:1-319) 10 20 30 40 50 60 pF1KE3 MELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 LLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRL 70 80 90 100 110 120 130 140 150 160 170 pF1KE3 LLGALQSLLGTQLPPQGRTTAH----KDPNAIFLSFQHLLRGKVRFLMLVGGSTL-CVRR :::::::::::: . . : : .: : .:. : .: . : .. NP_001 LLGALQSLLGTQDHSSQGSQCHLPELPTPAPRKGAFPDACR-RVHPLRQAGPTHHSCPQQ 130 140 150 160 170 180 190 200 210 220 230 pF1KE3 --APPTTAVPSRTSLVLTLNELPNRTSGLLETNFTASARTTGSGLLKWQQGFRAKIPGLL . : : . .. .. ..: : :. : ...:. . :... :. :.: NP_001 NLSSPHTERAPKQDFWIVGDKLHC-----LSQNYWLWASEVAAGIQS-QDSWSAE-PNL- 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE3 NQTSRSLDQIPGYLNRIHELLNGTRGLFPGPSRRTLGAPDISSGTSDTGSLPPNLQPGYS :.:: :: : . :: : . :: . ... . : . :.. . NP_001 --------QVPGPNPRIPE--QDTRTLEW--NSWTL-SWTLTQDPRSPGHFLRNIR--HR 240 250 260 270 300 310 320 330 340 350 pF1KE3 PSPTHPPTGQYTLFPLPPTLPTPVVQL--HPLLPDPSAPTPTPTSPLLNTSYTHSQNLSQ :.::. .. :: : . : : : : : .:.: :.: NP_001 LPATQPPAWIFS-FPNPSSYWT-VYALPSSTHLAHPCGPAPPPAS 280 290 300 310 pF1KE3 EG 353 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 04:51:10 2016 done: Sun Nov 6 04:51:12 2016 Total Scan time: 9.530 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]