FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2272, 213 aa 1>>>pF1KE2272 213 - 213 aa - 213 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.2933+/-0.000404; mu= 12.1669+/- 0.025 mean_var=138.8450+/-27.496, 0's: 0 Z-trim(115.0): 51 B-trim: 572 in 1/58 Lambda= 0.108845 statistics sampled from 25184 (25226) to 25184 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.652), E-opt: 0.2 (0.296), width: 16 Scan time: 6.370 The best scores are: opt bits E(85289) NP_054762 (OMIM: 600795,609512,614696) charged mul ( 213) 1310 216.6 2.5e-56 XP_011531878 (OMIM: 600795,609512,614696) PREDICTE ( 229) 1252 207.5 1.4e-53 NP_001231573 (OMIM: 600795,609512,614696) charged ( 172) 1056 176.6 2.2e-44 NP_940818 (OMIM: 610893) charged multivesicular bo ( 222) 427 77.9 1.4e-14 NP_055268 (OMIM: 610893) charged multivesicular bo ( 222) 427 77.9 1.4e-14 XP_005258804 (OMIM: 610893) PREDICTED: charged mul ( 265) 395 73.0 5.2e-13 XP_005258803 (OMIM: 610893) PREDICTED: charged mul ( 265) 395 73.0 5.2e-13 NP_057163 (OMIM: 610052) charged multivesicular bo ( 222) 311 59.7 4.3e-09 NP_001005753 (OMIM: 610052) charged multivesicular ( 156) 203 42.6 0.00043 NP_065145 (OMIM: 606486) charged multivesicular bo ( 199) 195 41.4 0.0012 NP_002759 (OMIM: 164010,614961) charged multivesic ( 196) 179 38.9 0.0068 >>NP_054762 (OMIM: 600795,609512,614696) charged multive (213 aa) initn: 1310 init1: 1310 opt: 1310 Z-score: 1132.3 bits: 216.6 E(85289): 2.5e-56 Smith-Waterman score: 1310; 100.0% identity (100.0% similar) in 213 aa overlap (1-213:1-213) 10 20 30 40 50 60 pF1KE2 MASLFKKKTVDDVIKEQNRELRGTQRAIIRDRAALEKQEKQLELEIKKMAKIGNKEACKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_054 MASLFKKKTVDDVIKEQNRELRGTQRAIIRDRAALEKQEKQLELEIKKMAKIGNKEACKV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 LAKQLVHLRKQKTRTFAVSSKVTSMSTQTKVMNSQMKMAGAMSTTAKTMQAVNKKMDPQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_054 LAKQLVHLRKQKTRTFAVSSKVTSMSTQTKVMNSQMKMAGAMSTTAKTMQAVNKKMDPQK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 TLQTMQNFQKENMKMEMTEEMINDTLDDIFDGSDDEEESQDIVNQVLDEIGIEISGKMAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_054 TLQTMQNFQKENMKMEMTEEMINDTLDDIFDGSDDEEESQDIVNQVLDEIGIEISGKMAK 130 140 150 160 170 180 190 200 210 pF1KE2 APSAARSLPSASTSKATISDEEIERQLKALGVD ::::::::::::::::::::::::::::::::: NP_054 APSAARSLPSASTSKATISDEEIERQLKALGVD 190 200 210 >>XP_011531878 (OMIM: 600795,609512,614696) PREDICTED: c (229 aa) initn: 1247 init1: 1247 opt: 1252 Z-score: 1082.7 bits: 207.5 E(85289): 1.4e-53 Smith-Waterman score: 1252; 96.2% identity (97.6% similar) in 211 aa overlap (3-213:19-229) 10 20 30 40 pF1KE2 MASLFKKKTVDDVIKEQNRELRGTQRAIIRDRAALEKQEKQLEL : .. . ::::::::::::::::::::::::::::::::: XP_011 MISAQRNHHLPDSSDSSTSAYRVARITDVIKEQNRELRGTQRAIIRDRAALEKQEKQLEL 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE2 EIKKMAKIGNKEACKVLAKQLVHLRKQKTRTFAVSSKVTSMSTQTKVMNSQMKMAGAMST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EIKKMAKIGNKEACKVLAKQLVHLRKQKTRTFAVSSKVTSMSTQTKVMNSQMKMAGAMST 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE2 TAKTMQAVNKKMDPQKTLQTMQNFQKENMKMEMTEEMINDTLDDIFDGSDDEEESQDIVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TAKTMQAVNKKMDPQKTLQTMQNFQKENMKMEMTEEMINDTLDDIFDGSDDEEESQDIVN 130 140 150 160 170 180 170 180 190 200 210 pF1KE2 QVLDEIGIEISGKMAKAPSAARSLPSASTSKATISDEEIERQLKALGVD ::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QVLDEIGIEISGKMAKAPSAARSLPSASTSKATISDEEIERQLKALGVD 190 200 210 220 >>NP_001231573 (OMIM: 600795,609512,614696) charged mult (172 aa) initn: 1056 init1: 1056 opt: 1056 Z-score: 917.9 bits: 176.6 E(85289): 2.2e-44 Smith-Waterman score: 1056; 99.4% identity (100.0% similar) in 172 aa overlap (42-213:1-172) 20 30 40 50 60 70 pF1KE2 DVIKEQNRELRGTQRAIIRDRAALEKQEKQLELEIKKMAKIGNKEACKVLAKQLVHLRKQ .::::::::::::::::::::::::::::: NP_001 MELEIKKMAKIGNKEACKVLAKQLVHLRKQ 10 20 30 80 90 100 110 120 130 pF1KE2 KTRTFAVSSKVTSMSTQTKVMNSQMKMAGAMSTTAKTMQAVNKKMDPQKTLQTMQNFQKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KTRTFAVSSKVTSMSTQTKVMNSQMKMAGAMSTTAKTMQAVNKKMDPQKTLQTMQNFQKE 40 50 60 70 80 90 140 150 160 170 180 190 pF1KE2 NMKMEMTEEMINDTLDDIFDGSDDEEESQDIVNQVLDEIGIEISGKMAKAPSAARSLPSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NMKMEMTEEMINDTLDDIFDGSDDEEESQDIVNQVLDEIGIEISGKMAKAPSAARSLPSA 100 110 120 130 140 150 200 210 pF1KE2 STSKATISDEEIERQLKALGVD :::::::::::::::::::::: NP_001 STSKATISDEEIERQLKALGVD 160 170 >>NP_940818 (OMIM: 610893) charged multivesicular body p (222 aa) initn: 482 init1: 365 opt: 427 Z-score: 382.7 bits: 77.9 E(85289): 1.4e-14 Smith-Waterman score: 427; 33.3% identity (69.8% similar) in 222 aa overlap (1-213:1-222) 10 20 30 40 50 pF1KE2 MASLF-KKKTVDDVIKEQNRELRGTQRAIIRDRAALEKQEKQLELEIKKMAKIGNKEACK : :: ..:: ........: : ..: . :.: :: :::.. .:::::: :. .: . NP_940 MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVR 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 VLAKQLVHLRKQKTRTFAVSSKVTSMSTQTKVMNSQMKMAGAMSTTAKTMQAVNKKMDPQ ..::.::. :. . . ... ..: . ....:. .:: ::. ..:.: ..:... NP_940 IMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLP 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 KTLQTMQNFQKENMKMEMTEEMINDTLDDIFDGSDDEEESQDIVNQVLDEIGIEISGKMA . . :..:... :.: :::.::..:: . .:::::. .:.:::::.:. .. ... NP_940 QIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELS 130 140 150 160 170 180 180 190 200 210 pF1KE2 KAPSAARSLPSASTSK---ATIS-----DEEIERQLKALGVD . ::.. :: :. .: :. : : ..:..:: : : NP_940 NLPSTGGSLSVAAGGKKAEAAASALADADADLEERLKNLRRD 190 200 210 220 >>NP_055268 (OMIM: 610893) charged multivesicular body p (222 aa) initn: 482 init1: 365 opt: 427 Z-score: 382.7 bits: 77.9 E(85289): 1.4e-14 Smith-Waterman score: 427; 33.3% identity (69.8% similar) in 222 aa overlap (1-213:1-222) 10 20 30 40 50 pF1KE2 MASLF-KKKTVDDVIKEQNRELRGTQRAIIRDRAALEKQEKQLELEIKKMAKIGNKEACK : :: ..:: ........: : ..: . :.: :: :::.. .:::::: :. .: . NP_055 MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVR 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 VLAKQLVHLRKQKTRTFAVSSKVTSMSTQTKVMNSQMKMAGAMSTTAKTMQAVNKKMDPQ ..::.::. :. . . ... ..: . ....:. .:: ::. ..:.: ..:... NP_055 IMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLP 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 KTLQTMQNFQKENMKMEMTEEMINDTLDDIFDGSDDEEESQDIVNQVLDEIGIEISGKMA . . :..:... :.: :::.::..:: . .:::::. .:.:::::.:. .. ... NP_055 QIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELS 130 140 150 160 170 180 180 190 200 210 pF1KE2 KAPSAARSLPSASTSK---ATIS-----DEEIERQLKALGVD . ::.. :: :. .: :. : : ..:..:: : : NP_055 NLPSTGGSLSVAAGGKKAEAAASALADADADLEERLKNLRRD 190 200 210 220 >>XP_005258804 (OMIM: 610893) PREDICTED: charged multive (265 aa) initn: 455 init1: 338 opt: 395 Z-score: 354.6 bits: 73.0 E(85289): 5.2e-13 Smith-Waterman score: 395; 32.3% identity (70.7% similar) in 198 aa overlap (1-197:1-197) 10 20 30 40 50 pF1KE2 MASLF-KKKTVDDVIKEQNRELRGTQRAIIRDRAALEKQEKQLELEIKKMAKIGNKEACK : :: ..:: ........: : ..: . :.: :: :::.. .:::::: :. .: . XP_005 MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVR 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 VLAKQLVHLRKQKTRTFAVSSKVTSMSTQTKVMNSQMKMAGAMSTTAKTMQAVNKKMDPQ ..::.::. :. . . ... ..: . ....:. .:: ::. ..:.: ..:... XP_005 IMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLP 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 KTLQTMQNFQKENMKMEMTEEMINDTLDDIFDGSDDEEESQDIVNQVLDEIGIEISGKMA . . :..:... :.: :::.::..:: . .:::::. .:.:::::.:. .. ... XP_005 QIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELS 130 140 150 160 170 180 180 190 200 210 pF1KE2 KAPSAARSLPSASTSKATISDEEIERQLKALGVD . : . . : . . :: XP_005 SECSKSWT-PFPTQGPATAPSPPFPCITPLRCLTPPAQTPTFSADLPSTGGSLSVAAGGK 190 200 210 220 230 >>XP_005258803 (OMIM: 610893) PREDICTED: charged multive (265 aa) initn: 455 init1: 338 opt: 395 Z-score: 354.6 bits: 73.0 E(85289): 5.2e-13 Smith-Waterman score: 395; 32.3% identity (70.7% similar) in 198 aa overlap (1-197:1-197) 10 20 30 40 50 pF1KE2 MASLF-KKKTVDDVIKEQNRELRGTQRAIIRDRAALEKQEKQLELEIKKMAKIGNKEACK : :: ..:: ........: : ..: . :.: :: :::.. .:::::: :. .: . XP_005 MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVR 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 VLAKQLVHLRKQKTRTFAVSSKVTSMSTQTKVMNSQMKMAGAMSTTAKTMQAVNKKMDPQ ..::.::. :. . . ... ..: . ....:. .:: ::. ..:.: ..:... XP_005 IMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLP 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 KTLQTMQNFQKENMKMEMTEEMINDTLDDIFDGSDDEEESQDIVNQVLDEIGIEISGKMA . . :..:... :.: :::.::..:: . .:::::. .:.:::::.:. .. ... XP_005 QIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELS 130 140 150 160 170 180 180 190 200 210 pF1KE2 KAPSAARSLPSASTSKATISDEEIERQLKALGVD . : . . : . . :: XP_005 SECSKSWT-PFPTQGPATAPSPPFPCITPLRCLTPPAQTPTFSADLPSTGGSLSVAAGGK 190 200 210 220 230 >>NP_057163 (OMIM: 610052) charged multivesicular body p (222 aa) initn: 332 init1: 241 opt: 311 Z-score: 284.3 bits: 59.7 E(85289): 4.3e-09 Smith-Waterman score: 311; 27.5% identity (68.6% similar) in 207 aa overlap (6-210:8-210) 10 20 30 40 50 pF1KE2 MASLFKKKTVDDVIKEQNRELRGTQRAIIRDRAALEKQEKQLELEIKKMAKIGNKEAC ..: ....: . ..: .:.. :. ....:.... .: :: :.:..: NP_057 MGLFGKTQEKPPKELVNEWSLKIRKEMRVVDRQIRDIQREEEKVKRSVKDAAKKGQKDVC 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 KVLAKQLVHLRKQKTRTFAVSSKVTSMSTQTKVMNSQMKMAGAMSTTAKTMQAVNKKMDP ::::.... :: .. .: .....:. : . . ...::... ....:.:... . NP_057 IVLAKEMIRSRKAVSKLYASKAHMNSVLMGMKNQLAVLRVAGSLQKSTEVMKAMQSLVKI 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 QKTLQTMQNFQKENMKMEMTEEMINDTLDDIFDGSDDEEESQDIVNQVLDEIGIEIS-GK . ::....:: :: . :::..:: :.. ::.:: .. ... .:.: .::. : NP_057 PEIQATMRELSKEMMKAGIIEEMLEDT----FESMDDQEEMEEEAEMEIDRILFEITAGA 130 140 150 160 170 180 190 200 210 pF1KE2 MAKAPSAAR-SLPSASTSKATISDEEIERQLKALGVD ..:::: . .:: : ..:. :.. .:: NP_057 LGKAPSKVTDALPEPEPPGAMAASEDEEEEEEALEAMQSRLATLRS 180 190 200 210 220 >>NP_001005753 (OMIM: 610052) charged multivesicular bod (156 aa) initn: 229 init1: 155 opt: 203 Z-score: 194.5 bits: 42.6 E(85289): 0.00043 Smith-Waterman score: 203; 27.7% identity (67.6% similar) in 148 aa overlap (65-210:1-144) 40 50 60 70 80 90 pF1KE2 LEKQEKQLELEIKKMAKIGNKEACKVLAKQLVHLRKQKTRTFAVSSKVTSMSTQTKVMNS ... :: .. .: .....:. : . . NP_001 MIRSRKAVSKLYASKAHMNSVLMGMKNQLA 10 20 30 100 110 120 130 140 150 pF1KE2 QMKMAGAMSTTAKTMQAVNKKMDPQKTLQTMQNFQKENMKMEMTEEMINDTLDDIFDGSD ...::... ....:.:... . . ::....:: :: . :::..:: :.. : NP_001 VLRVAGSLQKSTEVMKAMQSLVKIPEIQATMRELSKEMMKAGIIEEMLEDT----FESMD 40 50 60 70 80 160 170 180 190 200 210 pF1KE2 DEEESQDIVNQVLDEIGIEIS-GKMAKAPSAAR-SLPSASTSKATISDEEIERQLKALGV :.:: .. ... .:.: .::. : ..:::: . .:: : ..:. :.. .:: NP_001 DQEEMEEEAEMEIDRILFEITAGALGKAPSKVTDALPEPEPPGAMAASEDEEEEEEALEA 90 100 110 120 130 140 pF1KE2 D NP_001 MQSRLATLRS 150 >>NP_065145 (OMIM: 606486) charged multivesicular body p (199 aa) initn: 131 init1: 64 opt: 195 Z-score: 186.4 bits: 41.4 E(85289): 0.0012 Smith-Waterman score: 201; 19.5% identity (65.8% similar) in 190 aa overlap (21-210:11-195) 10 20 30 40 50 60 pF1KE2 MASLFKKKTVDDVIKEQNRELRGTQRAIIRDRAALEKQEKQLELEIKKMAKIGNKEACKV :. . . . :. .:.:: . .::: . :: :. .. NP_065 MSNMEKHLFNLKFAAKELSRSAKKCDKEEKAEKAKIKKAIQKGNMEVARI 10 20 30 40 50 70 80 90 100 110 120 pF1KE2 LAKQLVHLRKQKTRTFAVSSKVTSMSTQTKVMNSQMKMAGAMSTTAKTMQAVNKKMDPQK :.. .. ..: . . .:..: ........ .. :.. .:. ..:.:.:. : :. .: NP_065 HAENAIRQKNQAVNFLRMSARVDAVAARVQTAVTMGKVTKSMAGVVKSMDATLKTMNLEK 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE2 TLQTMQNFQKENMKMEMTEEMINDTLDDIFDGSDDEEESQDIVNQVLDEIGIEISGKMAK :..:... ... ....::... . ... . ..... :: :.... .. . NP_065 ISALMDKFEHQFETLDVQTQQMEDTMSSTTTLTTPQNQVDMLLQEMADEAGLDLNMELPQ 120 130 140 150 160 170 190 200 210 pF1KE2 APSAARSLPSASTSKATISDEEIERQLKALGVD . .. :..:: :. ..:. ..: : NP_065 GQTG-----SVGTSVASAEQDELSQRLARLRDQV 180 190 213 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 17:44:20 2016 done: Sun Nov 6 17:44:21 2016 Total Scan time: 6.370 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]