FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5268, 201 aa 1>>>pF1KE5268 201 - 201 aa - 201 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9575+/-0.000267; mu= 16.6545+/- 0.017 mean_var=77.6142+/-15.993, 0's: 0 Z-trim(121.9): 26 B-trim: 636 in 1/57 Lambda= 0.145581 statistics sampled from 39154 (39180) to 39154 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.799), E-opt: 0.2 (0.459), width: 16 Scan time: 5.910 The best scores are: opt bits E(85289) NP_005218 (OMIM: 601380) ephrin-A4 isoform a precu ( 201) 1417 305.8 2.9e-83 NP_872631 (OMIM: 601380) ephrin-A4 isoform b precu ( 207) 1131 245.8 3.6e-65 NP_872632 (OMIM: 601380) ephrin-A4 isoform c precu ( 193) 1128 245.1 5.3e-65 XP_006714628 (OMIM: 601535) PREDICTED: ephrin-A5 i ( 201) 515 116.4 3.1e-26 NP_001953 (OMIM: 601535) ephrin-A5 precursor [Homo ( 228) 480 109.1 5.6e-24 NP_004419 (OMIM: 191164) ephrin-A1 isoform a precu ( 205) 435 99.6 3.6e-21 XP_016881939 (OMIM: 602756) PREDICTED: ephrin-A2 i ( 202) 396 91.4 1.1e-18 NP_001396 (OMIM: 602756) ephrin-A2 precursor [Homo ( 213) 396 91.4 1.1e-18 XP_016881938 (OMIM: 602756) PREDICTED: ephrin-A2 i ( 298) 396 91.6 1.4e-18 XP_011541552 (OMIM: 601535) PREDICTED: ephrin-A5 i ( 210) 380 88.1 1.1e-17 NP_872626 (OMIM: 191164) ephrin-A1 isoform b precu ( 183) 377 87.4 1.6e-17 NP_004943 (OMIM: 601381) ephrin-A3 precursor [Homo ( 238) 333 78.2 1.1e-14 XP_011541553 (OMIM: 601535) PREDICTED: ephrin-A5 i ( 148) 247 60.0 2.2e-09 XP_016864694 (OMIM: 601535) PREDICTED: ephrin-A5 i ( 148) 247 60.0 2.2e-09 NP_004084 (OMIM: 600527) ephrin-B2 precursor [Homo ( 333) 215 53.6 4.2e-07 NP_001397 (OMIM: 602297) ephrin-B3 precursor [Homo ( 340) 215 53.6 4.3e-07 NP_004420 (OMIM: 300035,304110) ephrin-B1 precurso ( 346) 208 52.1 1.2e-06 >>NP_005218 (OMIM: 601380) ephrin-A4 isoform a precursor (201 aa) initn: 1417 init1: 1417 opt: 1417 Z-score: 1615.7 bits: 305.8 E(85289): 2.9e-83 Smith-Waterman score: 1417; 100.0% identity (100.0% similar) in 201 aa overlap (1-201:1-201) 10 20 30 40 50 60 pF1KE5 MRLLPLLRTVLWAAFLGSPLRGGSSLRHVVYWNSSNPRLLRGDAVVELGLNDYLDIVCPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MRLLPLLRTVLWAAFLGSPLRGGSSLRHVVYWNSSNPRLLRGDAVVELGLNDYLDIVCPH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 YEGPGPPEGPETFALYMVDWPGYESCQAEGPRAYKRWVCSLPFGHVQFSEKIQRFTPFSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 YEGPGPPEGPETFALYMVDWPGYESCQAEGPRAYKRWVCSLPFGHVQFSEKIQRFTPFSL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 GFEFLPGETYYYISVPTPESSGQCLRLQVSVCCKERKSESAHPVGSPGESGTSGWRGGDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GFEFLPGETYYYISVPTPESSGQCLRLQVSVCCKERKSESAHPVGSPGESGTSGWRGGDT 130 140 150 160 170 180 190 200 pF1KE5 PSPLCLLLLLLLLILRLLRIL ::::::::::::::::::::: NP_005 PSPLCLLLLLLLLILRLLRIL 190 200 >>NP_872631 (OMIM: 601380) ephrin-A4 isoform b precursor (207 aa) initn: 1143 init1: 1123 opt: 1131 Z-score: 1290.9 bits: 245.8 E(85289): 3.6e-65 Smith-Waterman score: 1131; 94.2% identity (97.1% similar) in 171 aa overlap (1-171:1-169) 10 20 30 40 50 60 pF1KE5 MRLLPLLRTVLWAAFLGSPLRGGSSLRHVVYWNSSNPRLLRGDAVVELGLNDYLDIVCPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_872 MRLLPLLRTVLWAAFLGSPLRGGSSLRHVVYWNSSNPRLLRGDAVVELGLNDYLDIVCPH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 YEGPGPPEGPETFALYMVDWPGYESCQAEGPRAYKRWVCSLPFGHVQFSEKIQRFTPFSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_872 YEGPGPPEGPETFALYMVDWPGYESCQAEGPRAYKRWVCSLPFGHVQFSEKIQRFTPFSL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 GFEFLPGETYYYISVPTPESSGQCLRLQVSVCCKERKSESAHPVGSPGESGTSGWRGGDT ::::::::::::::::::::::::::::::::::::... . : ::: .: NP_872 GFEFLPGETYYYISVPTPESSGQCLRLQVSVCCKERRAR-VLPR-SPGGGGIPAACTGGA 130 140 150 160 170 190 200 pF1KE5 PSPLCLLLLLLLLILRLLRIL NP_872 NSDRQDGALMGEIRGSEVTLAGACPLITG 180 190 200 >>NP_872632 (OMIM: 601380) ephrin-A4 isoform c precursor (193 aa) initn: 1140 init1: 1120 opt: 1128 Z-score: 1287.9 bits: 245.1 E(85289): 5.3e-65 Smith-Waterman score: 1128; 97.5% identity (98.2% similar) in 163 aa overlap (1-163:1-162) 10 20 30 40 50 60 pF1KE5 MRLLPLLRTVLWAAFLGSPLRGGSSLRHVVYWNSSNPRLLRGDAVVELGLNDYLDIVCPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_872 MRLLPLLRTVLWAAFLGSPLRGGSSLRHVVYWNSSNPRLLRGDAVVELGLNDYLDIVCPH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 YEGPGPPEGPETFALYMVDWPGYESCQAEGPRAYKRWVCSLPFGHVQFSEKIQRFTPFSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_872 YEGPGPPEGPETFALYMVDWPGYESCQAEGPRAYKRWVCSLPFGHVQFSEKIQRFTPFSL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 GFEFLPGETYYYISVPTPESSGQCLRLQVSVCCKERKSESAHPVGSPGESGTSGWRGGDT ::::::::::::::::::::::::::::::::::::. : :: NP_872 GFEFLPGETYYYISVPTPESSGQCLRLQVSVCCKERNLPS-HPKEPESSQDPLEEEGSLL 130 140 150 160 170 190 200 pF1KE5 PSPLCLLLLLLLLILRLLRIL NP_872 PALGVPIQTDKMEH 180 190 >>XP_006714628 (OMIM: 601535) PREDICTED: ephrin-A5 isofo (201 aa) initn: 527 init1: 253 opt: 515 Z-score: 591.9 bits: 116.4 E(85289): 3.1e-26 Smith-Waterman score: 515; 43.6% identity (67.6% similar) in 204 aa overlap (1-198:4-201) 10 20 30 40 50 pF1KE5 MRLLPLLRTVLWA-AFLGSPLRGGSSLRHVVYWNSSNPRLLRGDAVVELGLNDYLDI ...: :. ::: .: .: . . :..:::::::::. ::: ... .:::::. XP_006 MLHVEMLTLVFLVLWMCVFSQDPGSKAVADRYAVYWNSSNPRFQRGDYHIDVCINDYLDV 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE5 VCPHYEGPGPPEGPETFALYMVDWPGYESCQAEGPRAYKRWVCSLPF---GHVQFSEKIQ ::::: : . : ..::::.. :: .:. . ...::: :. : : ..::::.: XP_006 FCPHYEDSVPEDKTERYVLYMVNFDGYSACD-HTSKGFKRWECNRPHSPNGPLKFSEKFQ 70 80 90 100 110 120 130 140 150 160 170 pF1KE5 RFTPFSLGFEFLPGETYYYISVPTPESSGQ-CLRLQVSVC-CKERKSESAHPVGSPGESG :::::::::: ::. :.::: :... . ::.:.: : .. :::.: : ::.. XP_006 LFTPFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFVRPTNDTVHESAEP--SRGENA 120 130 140 150 160 170 180 190 200 pF1KE5 TSGWRGGDTPSPLCLLLLLLLLILRLLRIL .. : :: : .::.:: .: : XP_006 AQTPR---IPSRLLAILLFLLAMLLTL 180 190 200 >>NP_001953 (OMIM: 601535) ephrin-A5 precursor [Homo sap (228 aa) initn: 516 init1: 244 opt: 480 Z-score: 551.5 bits: 109.1 E(85289): 5.6e-24 Smith-Waterman score: 483; 39.4% identity (63.3% similar) in 226 aa overlap (1-200:4-228) 10 20 30 40 50 pF1KE5 MRLLPLLRTVLWA-AFLGSPLRGGSSLRHVVYWNSSNPRLLRGDAVVELGLNDYLDI ...: :. ::: .: .: . . :..:::::::::. ::: ... .:::::. NP_001 MLHVEMLTLVFLVLWMCVFSQDPGSKAVADRYAVYWNSSNPRFQRGDYHIDVCINDYLDV 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE5 VCPHYEGPGPPEGPETFALYMVDWPGYESCQAEGPRAYKRWVCSLPF---GHVQFSEKIQ ::::: : . : ..::::.. :: .:. . ...::: :. : : ..::::.: NP_001 FCPHYEDSVPEDKTERYVLYMVNFDGYSACDHTS-KGFKRWECNRPHSPNGPLKFSEKFQ 70 80 90 100 110 120 130 140 150 pF1KE5 RFTPFSLGFEFLPGETYYYISVPTPESSGQ-CLRLQVSV-----CCK------------E :::::::::: ::. :.::: :... . ::.:.: : : : . NP_001 LFTPFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFVRPTNSCMKTIGVHDRVFDVND 120 130 140 150 160 170 160 170 180 190 200 pF1KE5 RKSESAHPVGSP-GESG--TSGWRGGDTPS-PLCLLLLLLLLILRLLRIL . .: .:. . ::. . : ...:: : :: .::.:. :: . NP_001 KVENSLEPADDTVHESAEPSRGENAAQTPRIPSRLLAILLFLLAMLLTL 180 190 200 210 220 >>NP_004419 (OMIM: 191164) ephrin-A1 isoform a precursor (205 aa) initn: 427 init1: 196 opt: 435 Z-score: 501.0 bits: 99.6 E(85289): 3.6e-21 Smith-Waterman score: 435; 43.6% identity (67.3% similar) in 156 aa overlap (11-162:4-158) 10 20 30 40 50 60 pF1KE5 MRLLPLLRTVLWAAFLGSPLRGGSSLRHVVYWNSSNPRLLRGDAVVELGLNDYLDIVCPH ::: .:: ... ::.:.::::::.. : .... ::::.::.::: NP_004 MEFLWAPLLGLCCSLAAADRHTVFWNSSNPKFRNEDYTIHVQLNDYVDIICPH 10 20 30 40 50 70 80 90 100 110 pF1KE5 YEGPGPPEGP-ETFALYMVDWPGYESCQAEGPRAYKRWVCSLP---FGHVQFSEKIQRFT :: . .. : . ::.:. :. :: .. . :: :. : : ..:::.:::: NP_004 YEDHSVADAAMEQYILYLVEHEEYQLCQPQS-KDQVRWQCNRPSAKHGPEKLSEKFQRFT 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE5 PFSLGFEFLPGETYYYISVPTPESSGQCLRLQVSVCCKERKSESAHPVGSPGESGTSGWR ::.:: :: :..::::: : . .::::.:.: : .: .:: NP_004 PFTLGKEFKEGHSYYYISKPIHQHEDRCLRLKVTVSGKITHSPQAHDNPQEKRLAADDPE 120 130 140 150 160 170 180 190 200 pF1KE5 GGDTPSPLCLLLLLLLLILRLLRIL NP_004 VRVLHSIGHSAAPRLFPLAWTVLLLPLLLLQTP 180 190 200 >>XP_016881939 (OMIM: 602756) PREDICTED: ephrin-A2 isofo (202 aa) initn: 340 init1: 172 opt: 396 Z-score: 456.8 bits: 91.4 E(85289): 1.1e-18 Smith-Waterman score: 396; 44.8% identity (65.6% similar) in 163 aa overlap (42-198:46-199) 20 30 40 50 60 70 pF1KE5 WAAFLGSPLRGGSSLRHVVYWNSSNPRLLRGDAVVELGLNDYLDIVCPHYEGPGPP-EGP : .::...:::::: :::: .: :: : XP_016 ARFGTRASGLVRLRIALEPGRFHAGAGDDGGGYTVEVSINDYLDIYCPHYGAPLPPAERM 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 ETFALYMVDWPGYESCQAEGPRAYKRWVCSLPF---GHVQFSEKIQRFTPFSLGFEFLPG : ..::::. :. ::. . :..::: :. : : ..::::.: :::::::::: :: XP_016 EHYVLYMVNGEGHASCDHR-QRGFKRWECNRPAAPGGPLKFSEKFQLFTPFSLGFEFRPG 80 90 100 110 120 130 130 140 150 160 170 180 pF1KE5 ETYYYISVPTPESSGQ-CLRLQVSVC-CKERKSESAHPVGSPGESGTSGWRGGDTPSPLC . :::::. :.. . ::::.: : .: :. .:. . ..: .: :: : XP_016 HEYYYISATPPNAVDRPCLRLKVYVRPTNETLYEAPEPIFTSNNSCSSP--GG------C 140 150 160 170 180 190 200 pF1KE5 LLLLLLLLILRLLRIL :.: . .: : XP_016 RLFLSTIPVLWTLLGS 190 200 >>NP_001396 (OMIM: 602756) ephrin-A2 precursor [Homo sap (213 aa) initn: 440 init1: 172 opt: 396 Z-score: 456.5 bits: 91.4 E(85289): 1.1e-18 Smith-Waterman score: 445; 44.4% identity (65.2% similar) in 187 aa overlap (24-198:33-210) 10 20 30 40 pF1KE5 MRLLPLLRTVLWAAFLGSPLRGGSSLRHVVYWNSSNPRLLRGDA------VVE .: :..:::: ::::. : . .:: NP_001 PAQRPLLPLLLLLLPLPPPPFARAEDAARANSDRYAVYWNRSNPRFHAGAGDDGGGYTVE 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE5 LGLNDYLDIVCPHYEGPGPP-EGPETFALYMVDWPGYESCQAEGPRAYKRWVCSLPF--- ...:::::: :::: .: :: : : ..::::. :. ::. . :..::: :. : NP_001 VSINDYLDIYCPHYGAPLPPAERMEHYVLYMVNGEGHASCDHR-QRGFKRWECNRPAAPG 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE5 GHVQFSEKIQRFTPFSLGFEFLPGETYYYISVPTPESSGQ-CLRLQVSVC-CKERKSESA : ..::::.: :::::::::: ::. :::::. :.. . ::::.: : .: :. NP_001 GPLKFSEKFQLFTPFSLGFEFRPGHEYYYISATPPNAVDRPCLRLKVYVRPTNETLYEAP 130 140 150 160 170 180 170 180 190 200 pF1KE5 HPVGSPGESGTSGWRGGDTPSPLCLLLLLLLLILRLLRIL .:. . ..: .: :: : :.: . .: : NP_001 EPIFTSNNSCSSP--GG------CRLFLSTIPVLWTLLGS 190 200 210 >>XP_016881938 (OMIM: 602756) PREDICTED: ephrin-A2 isofo (298 aa) initn: 340 init1: 172 opt: 396 Z-score: 454.6 bits: 91.6 E(85289): 1.4e-18 Smith-Waterman score: 396; 44.8% identity (65.6% similar) in 163 aa overlap (42-198:142-295) 20 30 40 50 60 70 pF1KE5 WAAFLGSPLRGGSSLRHVVYWNSSNPRLLRGDAVVELGLNDYLDIVCPHYEGPGPP-EGP : .::...:::::: :::: .: :: : XP_016 ARFGTRASGLVRLRIALEPGRFHAGAGDDGGGYTVEVSINDYLDIYCPHYGAPLPPAERM 120 130 140 150 160 170 80 90 100 110 120 pF1KE5 ETFALYMVDWPGYESCQAEGPRAYKRWVCSLPF---GHVQFSEKIQRFTPFSLGFEFLPG : ..::::. :. ::. . :..::: :. : : ..::::.: :::::::::: :: XP_016 EHYVLYMVNGEGHASCDHR-QRGFKRWECNRPAAPGGPLKFSEKFQLFTPFSLGFEFRPG 180 190 200 210 220 230 130 140 150 160 170 180 pF1KE5 ETYYYISVPTPESSGQ-CLRLQVSVC-CKERKSESAHPVGSPGESGTSGWRGGDTPSPLC . :::::. :.. . ::::.: : .: :. .:. . ..: .: :: : XP_016 HEYYYISATPPNAVDRPCLRLKVYVRPTNETLYEAPEPIFTSNNSCSSP--GG------C 240 250 260 270 280 190 200 pF1KE5 LLLLLLLLILRLLRIL :.: . .: : XP_016 RLFLSTIPVLWTLLGS 290 >>XP_011541552 (OMIM: 601535) PREDICTED: ephrin-A5 isofo (210 aa) initn: 421 init1: 176 opt: 380 Z-score: 438.4 bits: 88.1 E(85289): 1.1e-17 Smith-Waterman score: 383; 38.9% identity (62.2% similar) in 185 aa overlap (41-200:27-210) 20 30 40 50 60 70 pF1KE5 LWAAFLGSPLRGGSSLRHVVYWNSSNPRLLRGDAVVELGLNDYLDIVCPHYEGPGPPEGP ::: ... .:::::. ::::: : . XP_011 MQTLEPACFRFSLHTNTNKQCTLGFQRGDYHIDVCINDYLDVFCPHYEDSVPEDKT 10 20 30 40 50 80 90 100 110 120 pF1KE5 ETFALYMVDWPGYESCQAEGPRAYKRWVCSLPF---GHVQFSEKIQRFTPFSLGFEFLPG : ..::::.. :: .:. . ...::: :. : : ..::::.: :::::::::: :: XP_011 ERYVLYMVNFDGYSACDHTS-KGFKRWECNRPHSPNGPLKFSEKFQLFTPFSLGFEFRPG 60 70 80 90 100 110 130 140 150 160 pF1KE5 ETYYYISVPTPESSGQ-CLRLQVSV-----CCK------------ERKSESAHPVGSP-G . :.::: :... . ::.:.: : : : .. .: .:. . XP_011 REYFYISSAIPDNGRRSCLKLKVFVRPTNSCMKTIGVHDRVFDVNDKVENSLEPADDTVH 120 130 140 150 160 170 170 180 190 200 pF1KE5 ESG--TSGWRGGDTPS-PLCLLLLLLLLILRLLRIL ::. . : ...:: : :: .::.:. :: . XP_011 ESAEPSRGENAAQTPRIPSRLLAILLFLLAMLLTL 180 190 200 210 201 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 23:17:31 2016 done: Mon Nov 7 23:17:32 2016 Total Scan time: 5.910 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]