FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2035, 629 aa 1>>>pF1KE2035 629 - 629 aa - 629 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.6643+/-0.000448; mu= 17.9708+/- 0.028 mean_var=85.4899+/-17.371, 0's: 0 Z-trim(110.1): 103 B-trim: 0 in 0/54 Lambda= 0.138713 statistics sampled from 18279 (18383) to 18279 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.573), E-opt: 0.2 (0.216), width: 16 Scan time: 10.440 The best scores are: opt bits E(85289) XP_011539093 (OMIM: 605606,607562,612261) PREDICTE ( 629) 4195 850.2 0 NP_653302 (OMIM: 605606,607562,612261) interleukin ( 629) 4195 850.2 0 XP_011539092 (OMIM: 605606,607562,612261) PREDICTE ( 629) 4195 850.2 0 XP_005270573 (OMIM: 605606,607562,612261) PREDICTE ( 375) 2465 503.9 4.2e-142 XP_016856693 (OMIM: 601642) PREDICTED: interleukin ( 498) 307 72.1 5.3e-12 NP_001245145 (OMIM: 601642) interleukin-12 recepto ( 635) 307 72.2 6.4e-12 NP_001306162 (OMIM: 601642) interleukin-12 recepto ( 659) 307 72.2 6.6e-12 XP_016856692 (OMIM: 601642) PREDICTED: interleukin ( 659) 307 72.2 6.6e-12 NP_001245143 (OMIM: 601642) interleukin-12 recepto ( 659) 307 72.2 6.6e-12 XP_016856691 (OMIM: 601642) PREDICTED: interleukin ( 700) 307 72.2 6.9e-12 NP_001245144 (OMIM: 601642) interleukin-12 recepto ( 776) 307 72.2 7.5e-12 XP_006710680 (OMIM: 601642) PREDICTED: interleukin ( 776) 307 72.2 7.5e-12 XP_011539686 (OMIM: 601642) PREDICTED: interleukin ( 809) 307 72.3 7.7e-12 XP_005270885 (OMIM: 601642) PREDICTED: interleukin ( 862) 307 72.3 8.1e-12 XP_005270882 (OMIM: 601642) PREDICTED: interleukin ( 862) 307 72.3 8.1e-12 XP_011539685 (OMIM: 601642) PREDICTED: interleukin ( 862) 307 72.3 8.1e-12 XP_005270884 (OMIM: 601642) PREDICTED: interleukin ( 862) 307 72.3 8.1e-12 NP_001550 (OMIM: 601642) interleukin-12 receptor s ( 862) 307 72.3 8.1e-12 NP_786943 (OMIM: 600694) interleukin-6 receptor su ( 329) 287 68.0 6.1e-11 NP_001177910 (OMIM: 600694) interleukin-6 receptor ( 857) 288 68.5 1.1e-10 NP_002175 (OMIM: 600694) interleukin-6 receptor su ( 918) 288 68.5 1.2e-10 XP_011526726 (OMIM: 272430,604237) PREDICTED: cyto ( 404) 225 55.6 3.9e-07 XP_011526725 (OMIM: 272430,604237) PREDICTED: cyto ( 419) 225 55.6 4e-07 NP_004741 (OMIM: 272430,604237) cytokine receptor- ( 422) 225 55.6 4e-07 XP_011526724 (OMIM: 272430,604237) PREDICTED: cyto ( 423) 225 55.6 4e-07 XP_011512342 (OMIM: 151443,601559) PREDICTED: leuk (1097) 223 55.5 1.1e-06 NP_002301 (OMIM: 151443,601559) leukemia inhibitor (1097) 223 55.5 1.1e-06 XP_016864952 (OMIM: 151443,601559) PREDICTED: leuk (1097) 223 55.5 1.1e-06 XP_011512344 (OMIM: 151443,601559) PREDICTED: leuk (1097) 223 55.5 1.1e-06 NP_001121143 (OMIM: 151443,601559) leukemia inhibi (1097) 223 55.5 1.1e-06 XP_016864951 (OMIM: 151443,601559) PREDICTED: leuk (1115) 223 55.5 1.1e-06 NP_001191247 (OMIM: 176761,615554,615555) prolacti ( 268) 155 41.5 0.0046 NP_001191246 (OMIM: 176761,615554,615555) prolacti ( 288) 154 41.3 0.0056 XP_016865135 (OMIM: 176761,615554,615555) PREDICTE ( 309) 154 41.3 0.006 NP_001191244 (OMIM: 176761,615554,615555) prolacti ( 349) 154 41.4 0.0066 NP_001191245 (OMIM: 176761,615554,615555) prolacti ( 376) 154 41.4 0.007 XP_016869752 (OMIM: 118946) PREDICTED: ciliary neu ( 372) 152 41.0 0.0091 NP_001193940 (OMIM: 118946) ciliary neurotrophic f ( 372) 152 41.0 0.0091 NP_001833 (OMIM: 118946) ciliary neurotrophic fact ( 372) 152 41.0 0.0091 XP_016869754 (OMIM: 118946) PREDICTED: ciliary neu ( 372) 152 41.0 0.0091 XP_016869753 (OMIM: 118946) PREDICTED: ciliary neu ( 372) 152 41.0 0.0091 NP_671693 (OMIM: 118946) ciliary neurotrophic fact ( 372) 152 41.0 0.0091 XP_016865134 (OMIM: 176761,615554,615555) PREDICTE ( 551) 154 41.5 0.0094 >>XP_011539093 (OMIM: 605606,607562,612261) PREDICTED: i (629 aa) initn: 4195 init1: 4195 opt: 4195 Z-score: 4540.1 bits: 850.2 E(85289): 0 Smith-Waterman score: 4195; 99.8% identity (99.8% similar) in 629 aa overlap (1-629:1-629) 10 20 30 40 50 60 pF1KE2 MNQVTIQWDAVIALYILFSWCHGGITNINCSGHIWVEPATIFKMGMNISIYCQAAIKNCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MNQVTIQWDAVIALYILFSWCHGGITNINCSGHIWVEPATIFKMGMNISIYCQAAIKNCQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 PRKLHFYKNGIKERFQITRINKTTARLWYKNFLEPHASMYCTAECPKHFQETLICGKDIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PRKLHFYKNGIKERFQITRINKTTARLWYKNFLEPHASMYCTAECPKHFQETLICGKDIS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 SGYPPDIPDEVTCVIYEYSGNMTCTWNAGKLTYIDTKYVVHVKSLETEEEQQYLTSSYIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SGYPPDIPDEVTCVIYEYSGNMTCTWNAGKLTYIDTKYVVHVKSLETEEEQQYLTSSYIN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 ISTDSLQGGKKYLVWVQAANALGMEESKQLQIHLDDIVIPSAAVISRAETINATVPKTII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ISTDSLQGGKKYLVWVQAANALGMEESKQLQIHLDDIVIPSAAVISRAETINATVPKTII 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 YWDSQTTIEKVSCEMRYKATTNQTWNVKEFDTNFTYVQQSEFYLEPNIKYVFQVRCQETG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YWDSQTTIEKVSCEMRYKATTNQTWNVKEFDTNFTYVQQSEFYLEPNIKYVFQVRCQETG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 KRYWQPWSSPFFHKTPETVPQVTSKAFQHDTWNSGLTVASISTGHLTSDNRGDIGLLLGM ::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KRYWQPWSSLFFHKTPETVPQVTSKAFQHDTWNSGLTVASISTGHLTSDNRGDIGLLLGM 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 IVFAVMLSILSLIGIFNRSFRTGIKRRILLLIPKWLYEDIPNMKNSNVVKMLQENSELMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IVFAVMLSILSLIGIFNRSFRTGIKRRILLLIPKWLYEDIPNMKNSNVVKMLQENSELMN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 NNSSEQVLYVDPMITEIKEIFIPEHKPTDYKKENTGPLETRDYPQNSLFDNTTVVYIPDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NNSSEQVLYVDPMITEIKEIFIPEHKPTDYKKENTGPLETRDYPQNSLFDNTTVVYIPDL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 NTGYKPQISNFLPEGSHLSNNNEITSLTLKPPVDSLDSGNNPRLQKHPNFAFSVSSVNSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NTGYKPQISNFLPEGSHLSNNNEITSLTLKPPVDSLDSGNNPRLQKHPNFAFSVSSVNSL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 SNTIFLGELSLILNQGECSSPDIQNSVEEETTMLLENDSPSETIPEQTLLPDEFVSCLGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SNTIFLGELSLILNQGECSSPDIQNSVEEETTMLLENDSPSETIPEQTLLPDEFVSCLGI 550 560 570 580 590 600 610 620 pF1KE2 VNEELPSINTYFPQNILESHFNRISLLEK ::::::::::::::::::::::::::::: XP_011 VNEELPSINTYFPQNILESHFNRISLLEK 610 620 >>NP_653302 (OMIM: 605606,607562,612261) interleukin-23 (629 aa) initn: 4195 init1: 4195 opt: 4195 Z-score: 4540.1 bits: 850.2 E(85289): 0 Smith-Waterman score: 4195; 99.8% identity (99.8% similar) in 629 aa overlap (1-629:1-629) 10 20 30 40 50 60 pF1KE2 MNQVTIQWDAVIALYILFSWCHGGITNINCSGHIWVEPATIFKMGMNISIYCQAAIKNCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 MNQVTIQWDAVIALYILFSWCHGGITNINCSGHIWVEPATIFKMGMNISIYCQAAIKNCQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 PRKLHFYKNGIKERFQITRINKTTARLWYKNFLEPHASMYCTAECPKHFQETLICGKDIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 PRKLHFYKNGIKERFQITRINKTTARLWYKNFLEPHASMYCTAECPKHFQETLICGKDIS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 SGYPPDIPDEVTCVIYEYSGNMTCTWNAGKLTYIDTKYVVHVKSLETEEEQQYLTSSYIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 SGYPPDIPDEVTCVIYEYSGNMTCTWNAGKLTYIDTKYVVHVKSLETEEEQQYLTSSYIN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 ISTDSLQGGKKYLVWVQAANALGMEESKQLQIHLDDIVIPSAAVISRAETINATVPKTII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 ISTDSLQGGKKYLVWVQAANALGMEESKQLQIHLDDIVIPSAAVISRAETINATVPKTII 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 YWDSQTTIEKVSCEMRYKATTNQTWNVKEFDTNFTYVQQSEFYLEPNIKYVFQVRCQETG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 YWDSQTTIEKVSCEMRYKATTNQTWNVKEFDTNFTYVQQSEFYLEPNIKYVFQVRCQETG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 KRYWQPWSSPFFHKTPETVPQVTSKAFQHDTWNSGLTVASISTGHLTSDNRGDIGLLLGM ::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 KRYWQPWSSLFFHKTPETVPQVTSKAFQHDTWNSGLTVASISTGHLTSDNRGDIGLLLGM 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 IVFAVMLSILSLIGIFNRSFRTGIKRRILLLIPKWLYEDIPNMKNSNVVKMLQENSELMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 IVFAVMLSILSLIGIFNRSFRTGIKRRILLLIPKWLYEDIPNMKNSNVVKMLQENSELMN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 NNSSEQVLYVDPMITEIKEIFIPEHKPTDYKKENTGPLETRDYPQNSLFDNTTVVYIPDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 NNSSEQVLYVDPMITEIKEIFIPEHKPTDYKKENTGPLETRDYPQNSLFDNTTVVYIPDL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 NTGYKPQISNFLPEGSHLSNNNEITSLTLKPPVDSLDSGNNPRLQKHPNFAFSVSSVNSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 NTGYKPQISNFLPEGSHLSNNNEITSLTLKPPVDSLDSGNNPRLQKHPNFAFSVSSVNSL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 SNTIFLGELSLILNQGECSSPDIQNSVEEETTMLLENDSPSETIPEQTLLPDEFVSCLGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 SNTIFLGELSLILNQGECSSPDIQNSVEEETTMLLENDSPSETIPEQTLLPDEFVSCLGI 550 560 570 580 590 600 610 620 pF1KE2 VNEELPSINTYFPQNILESHFNRISLLEK ::::::::::::::::::::::::::::: NP_653 VNEELPSINTYFPQNILESHFNRISLLEK 610 620 >>XP_011539092 (OMIM: 605606,607562,612261) PREDICTED: i (629 aa) initn: 4195 init1: 4195 opt: 4195 Z-score: 4540.1 bits: 850.2 E(85289): 0 Smith-Waterman score: 4195; 99.8% identity (99.8% similar) in 629 aa overlap (1-629:1-629) 10 20 30 40 50 60 pF1KE2 MNQVTIQWDAVIALYILFSWCHGGITNINCSGHIWVEPATIFKMGMNISIYCQAAIKNCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MNQVTIQWDAVIALYILFSWCHGGITNINCSGHIWVEPATIFKMGMNISIYCQAAIKNCQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 PRKLHFYKNGIKERFQITRINKTTARLWYKNFLEPHASMYCTAECPKHFQETLICGKDIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PRKLHFYKNGIKERFQITRINKTTARLWYKNFLEPHASMYCTAECPKHFQETLICGKDIS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 SGYPPDIPDEVTCVIYEYSGNMTCTWNAGKLTYIDTKYVVHVKSLETEEEQQYLTSSYIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SGYPPDIPDEVTCVIYEYSGNMTCTWNAGKLTYIDTKYVVHVKSLETEEEQQYLTSSYIN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 ISTDSLQGGKKYLVWVQAANALGMEESKQLQIHLDDIVIPSAAVISRAETINATVPKTII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ISTDSLQGGKKYLVWVQAANALGMEESKQLQIHLDDIVIPSAAVISRAETINATVPKTII 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 YWDSQTTIEKVSCEMRYKATTNQTWNVKEFDTNFTYVQQSEFYLEPNIKYVFQVRCQETG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YWDSQTTIEKVSCEMRYKATTNQTWNVKEFDTNFTYVQQSEFYLEPNIKYVFQVRCQETG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 KRYWQPWSSPFFHKTPETVPQVTSKAFQHDTWNSGLTVASISTGHLTSDNRGDIGLLLGM ::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KRYWQPWSSLFFHKTPETVPQVTSKAFQHDTWNSGLTVASISTGHLTSDNRGDIGLLLGM 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 IVFAVMLSILSLIGIFNRSFRTGIKRRILLLIPKWLYEDIPNMKNSNVVKMLQENSELMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IVFAVMLSILSLIGIFNRSFRTGIKRRILLLIPKWLYEDIPNMKNSNVVKMLQENSELMN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 NNSSEQVLYVDPMITEIKEIFIPEHKPTDYKKENTGPLETRDYPQNSLFDNTTVVYIPDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NNSSEQVLYVDPMITEIKEIFIPEHKPTDYKKENTGPLETRDYPQNSLFDNTTVVYIPDL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 NTGYKPQISNFLPEGSHLSNNNEITSLTLKPPVDSLDSGNNPRLQKHPNFAFSVSSVNSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NTGYKPQISNFLPEGSHLSNNNEITSLTLKPPVDSLDSGNNPRLQKHPNFAFSVSSVNSL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 SNTIFLGELSLILNQGECSSPDIQNSVEEETTMLLENDSPSETIPEQTLLPDEFVSCLGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SNTIFLGELSLILNQGECSSPDIQNSVEEETTMLLENDSPSETIPEQTLLPDEFVSCLGI 550 560 570 580 590 600 610 620 pF1KE2 VNEELPSINTYFPQNILESHFNRISLLEK ::::::::::::::::::::::::::::: XP_011 VNEELPSINTYFPQNILESHFNRISLLEK 610 620 >>XP_005270573 (OMIM: 605606,607562,612261) PREDICTED: i (375 aa) initn: 2465 init1: 2465 opt: 2465 Z-score: 2672.2 bits: 503.9 E(85289): 4.2e-142 Smith-Waterman score: 2465; 99.7% identity (99.7% similar) in 375 aa overlap (255-629:1-375) 230 240 250 260 270 280 pF1KE2 ISRAETINATVPKTIIYWDSQTTIEKVSCEMRYKATTNQTWNVKEFDTNFTYVQQSEFYL :::::::::::::::::::::::::::::: XP_005 MRYKATTNQTWNVKEFDTNFTYVQQSEFYL 10 20 30 290 300 310 320 330 340 pF1KE2 EPNIKYVFQVRCQETGKRYWQPWSSPFFHKTPETVPQVTSKAFQHDTWNSGLTVASISTG ::::::::::::::::::::::::: :::::::::::::::::::::::::::::::::: XP_005 EPNIKYVFQVRCQETGKRYWQPWSSLFFHKTPETVPQVTSKAFQHDTWNSGLTVASISTG 40 50 60 70 80 90 350 360 370 380 390 400 pF1KE2 HLTSDNRGDIGLLLGMIVFAVMLSILSLIGIFNRSFRTGIKRRILLLIPKWLYEDIPNMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HLTSDNRGDIGLLLGMIVFAVMLSILSLIGIFNRSFRTGIKRRILLLIPKWLYEDIPNMK 100 110 120 130 140 150 410 420 430 440 450 460 pF1KE2 NSNVVKMLQENSELMNNNSSEQVLYVDPMITEIKEIFIPEHKPTDYKKENTGPLETRDYP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NSNVVKMLQENSELMNNNSSEQVLYVDPMITEIKEIFIPEHKPTDYKKENTGPLETRDYP 160 170 180 190 200 210 470 480 490 500 510 520 pF1KE2 QNSLFDNTTVVYIPDLNTGYKPQISNFLPEGSHLSNNNEITSLTLKPPVDSLDSGNNPRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QNSLFDNTTVVYIPDLNTGYKPQISNFLPEGSHLSNNNEITSLTLKPPVDSLDSGNNPRL 220 230 240 250 260 270 530 540 550 560 570 580 pF1KE2 QKHPNFAFSVSSVNSLSNTIFLGELSLILNQGECSSPDIQNSVEEETTMLLENDSPSETI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QKHPNFAFSVSSVNSLSNTIFLGELSLILNQGECSSPDIQNSVEEETTMLLENDSPSETI 280 290 300 310 320 330 590 600 610 620 pF1KE2 PEQTLLPDEFVSCLGIVNEELPSINTYFPQNILESHFNRISLLEK ::::::::::::::::::::::::::::::::::::::::::::: XP_005 PEQTLLPDEFVSCLGIVNEELPSINTYFPQNILESHFNRISLLEK 340 350 360 370 >>XP_016856693 (OMIM: 601642) PREDICTED: interleukin-12 (498 aa) initn: 226 init1: 132 opt: 307 Z-score: 336.5 bits: 72.1 E(85289): 5.3e-12 Smith-Waterman score: 307; 23.5% identity (56.0% similar) in 327 aa overlap (12-320:10-321) 10 20 30 40 50 pF1KE2 MNQVTIQWDAVIALYILFSWCHGGITNINCS-GHIWVEPATIFKMGMNISIYCQAAIKNC .:......: :. : . :.:. .. .: ...: : . XP_016 MAHTFRGCSLAFMFIITWLLIKAKIDACKRGDVTVKPSHVILLGSTVNITC-----SL 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 QPRK--LHFYKNG--IKERFQITRINKTTARLWYKNF--LEPHASMY-CTAECPKHFQET .::. .:. . . : .:. ::: .. .. : .... : : . .: XP_016 KPRQGCFHYSRRNKLILYKFD-RRINFHHGHSLNSQVTGLPLGTTLFVCKLACINS-DEI 60 70 80 90 100 110 120 130 140 150 160 pF1KE2 LICGKDISSGYPPDIPDEVTCVIYEYSGNMTCTWNAGKLTYIDTKYVVHV---KSLETEE ::: .: : :. :....:. .:...:::. :. :.. :.:.... :.: .. XP_016 QICGAEIFVGVAPEQPQNLSCIQKGEQGTVACTWERGRDTHLYTEYTLQLSGPKNLTWQK 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE2 EQQYLTSSY----INISTDSLQGGKKYLVWVQAANALGMEESKQLQIHLDDIVIPSAAVI . . . .: ::.. .: .. .. . : :.:.:: : . . ::: : XP_016 QCKDIYCDYLDFGINLTPESPES--NFTAKVTAVNSLGSSSSLPSTFTFLDIVRPLPPWD 180 190 200 210 220 230 240 250 260 270 280 pF1KE2 SRAETINATVPKTIIYWDSQTTIEKVSCEMRYKATTNQTWNVKEFDTNFTYVQ--QSEFY : . .:.: . .:: .. . . ..::. .... ::. .: : .. .. . XP_016 IRIKFQKASVSRCTLYWRDEGLV--LLNRLRYRPSNSRLWNM----VNVTKAKGRHDLLD 230 240 250 260 270 280 290 300 310 320 330 340 pF1KE2 LEPNIKYVFQVRCQ-ETGKRYWQPWSSPFFHKTPETVPQVTSKAFQHDTWNSGLTVASIS :.: .: ::. . . : :. :: . .::: : XP_016 LKPFTEYEFQISSKLHLYKGSWSDWSESLRAQTPEEEPTGMLDVWYMKRHIDYSRQQISL 290 300 310 320 330 340 350 360 370 380 390 400 pF1KE2 TGHLTSDNRGDIGLLLGMIVFAVMLSILSLIGIFNRSFRTGIKRRILLLIPKWLYEDIPN XP_016 FWKNLSVSEARGKILHYQVTLQELTGGKAMTQNITGHTSWTTVIPRTGNWAVAVSAANSK 350 360 370 380 390 400 >>NP_001245145 (OMIM: 601642) interleukin-12 receptor su (635 aa) initn: 226 init1: 132 opt: 307 Z-score: 335.0 bits: 72.2 E(85289): 6.4e-12 Smith-Waterman score: 307; 23.5% identity (56.0% similar) in 327 aa overlap (12-320:10-321) 10 20 30 40 50 pF1KE2 MNQVTIQWDAVIALYILFSWCHGGITNINCS-GHIWVEPATIFKMGMNISIYCQAAIKNC .:......: :. : . :.:. .. .: ...: : . NP_001 MAHTFRGCSLAFMFIITWLLIKAKIDACKRGDVTVKPSHVILLGSTVNITC-----SL 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 QPRK--LHFYKNG--IKERFQITRINKTTARLWYKNF--LEPHASMY-CTAECPKHFQET .::. .:. . . : .:. ::: .. .. : .... : : . .: NP_001 KPRQGCFHYSRRNKLILYKFD-RRINFHHGHSLNSQVTGLPLGTTLFVCKLACINS-DEI 60 70 80 90 100 110 120 130 140 150 160 pF1KE2 LICGKDISSGYPPDIPDEVTCVIYEYSGNMTCTWNAGKLTYIDTKYVVHV---KSLETEE ::: .: : :. :....:. .:...:::. :. :.. :.:.... :.: .. NP_001 QICGAEIFVGVAPEQPQNLSCIQKGEQGTVACTWERGRDTHLYTEYTLQLSGPKNLTWQK 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE2 EQQYLTSSY----INISTDSLQGGKKYLVWVQAANALGMEESKQLQIHLDDIVIPSAAVI . . . .: ::.. .: .. .. . : :.:.:: : . . ::: : NP_001 QCKDIYCDYLDFGINLTPESPES--NFTAKVTAVNSLGSSSSLPSTFTFLDIVRPLPPWD 180 190 200 210 220 230 240 250 260 270 280 pF1KE2 SRAETINATVPKTIIYWDSQTTIEKVSCEMRYKATTNQTWNVKEFDTNFTYVQ--QSEFY : . .:.: . .:: .. . . ..::. .... ::. .: : .. .. . NP_001 IRIKFQKASVSRCTLYWRDEGLV--LLNRLRYRPSNSRLWNM----VNVTKAKGRHDLLD 230 240 250 260 270 280 290 300 310 320 330 340 pF1KE2 LEPNIKYVFQVRCQ-ETGKRYWQPWSSPFFHKTPETVPQVTSKAFQHDTWNSGLTVASIS :.: .: ::. . . : :. :: . .::: : NP_001 LKPFTEYEFQISSKLHLYKGSWSDWSESLRAQTPEEEPTGMLDVWYMKRHIDYSRQQISL 290 300 310 320 330 340 350 360 370 380 390 400 pF1KE2 TGHLTSDNRGDIGLLLGMIVFAVMLSILSLIGIFNRSFRTGIKRRILLLIPKWLYEDIPN NP_001 FWKNLSVSEARGKILHYQVTLQELTGGKAMTQNITGHTSWTTVIPRTGNWAVAVSAANSK 350 360 370 380 390 400 >>NP_001306162 (OMIM: 601642) interleukin-12 receptor su (659 aa) initn: 226 init1: 132 opt: 307 Z-score: 334.8 bits: 72.2 E(85289): 6.6e-12 Smith-Waterman score: 307; 23.5% identity (56.0% similar) in 327 aa overlap (12-320:10-321) 10 20 30 40 50 pF1KE2 MNQVTIQWDAVIALYILFSWCHGGITNINCS-GHIWVEPATIFKMGMNISIYCQAAIKNC .:......: :. : . :.:. .. .: ...: : . NP_001 MAHTFRGCSLAFMFIITWLLIKAKIDACKRGDVTVKPSHVILLGSTVNITC-----SL 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 QPRK--LHFYKNG--IKERFQITRINKTTARLWYKNF--LEPHASMY-CTAECPKHFQET .::. .:. . . : .:. ::: .. .. : .... : : . .: NP_001 KPRQGCFHYSRRNKLILYKFD-RRINFHHGHSLNSQVTGLPLGTTLFVCKLACINS-DEI 60 70 80 90 100 110 120 130 140 150 160 pF1KE2 LICGKDISSGYPPDIPDEVTCVIYEYSGNMTCTWNAGKLTYIDTKYVVHV---KSLETEE ::: .: : :. :....:. .:...:::. :. :.. :.:.... :.: .. NP_001 QICGAEIFVGVAPEQPQNLSCIQKGEQGTVACTWERGRDTHLYTEYTLQLSGPKNLTWQK 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE2 EQQYLTSSY----INISTDSLQGGKKYLVWVQAANALGMEESKQLQIHLDDIVIPSAAVI . . . .: ::.. .: .. .. . : :.:.:: : . . ::: : NP_001 QCKDIYCDYLDFGINLTPESPES--NFTAKVTAVNSLGSSSSLPSTFTFLDIVRPLPPWD 180 190 200 210 220 230 240 250 260 270 280 pF1KE2 SRAETINATVPKTIIYWDSQTTIEKVSCEMRYKATTNQTWNVKEFDTNFTYVQ--QSEFY : . .:.: . .:: .. . . ..::. .... ::. .: : .. .. . NP_001 IRIKFQKASVSRCTLYWRDEGLV--LLNRLRYRPSNSRLWNM----VNVTKAKGRHDLLD 230 240 250 260 270 280 290 300 310 320 330 340 pF1KE2 LEPNIKYVFQVRCQ-ETGKRYWQPWSSPFFHKTPETVPQVTSKAFQHDTWNSGLTVASIS :.: .: ::. . . : :. :: . .::: : NP_001 LKPFTEYEFQISSKLHLYKGSWSDWSESLRAQTPEEEPTGMLDVWYMKRHIDYSRQQISL 290 300 310 320 330 340 350 360 370 380 390 400 pF1KE2 TGHLTSDNRGDIGLLLGMIVFAVMLSILSLIGIFNRSFRTGIKRRILLLIPKWLYEDIPN NP_001 FWKNLSVSEARGKILHYQVTLQELTGGKAMTQNITGHTSWTTVIPRTGNWAVAVSAANSK 350 360 370 380 390 400 >>XP_016856692 (OMIM: 601642) PREDICTED: interleukin-12 (659 aa) initn: 226 init1: 132 opt: 307 Z-score: 334.8 bits: 72.2 E(85289): 6.6e-12 Smith-Waterman score: 307; 23.5% identity (56.0% similar) in 327 aa overlap (12-320:10-321) 10 20 30 40 50 pF1KE2 MNQVTIQWDAVIALYILFSWCHGGITNINCS-GHIWVEPATIFKMGMNISIYCQAAIKNC .:......: :. : . :.:. .. .: ...: : . XP_016 MAHTFRGCSLAFMFIITWLLIKAKIDACKRGDVTVKPSHVILLGSTVNITC-----SL 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 QPRK--LHFYKNG--IKERFQITRINKTTARLWYKNF--LEPHASMY-CTAECPKHFQET .::. .:. . . : .:. ::: .. .. : .... : : . .: XP_016 KPRQGCFHYSRRNKLILYKFD-RRINFHHGHSLNSQVTGLPLGTTLFVCKLACINS-DEI 60 70 80 90 100 110 120 130 140 150 160 pF1KE2 LICGKDISSGYPPDIPDEVTCVIYEYSGNMTCTWNAGKLTYIDTKYVVHV---KSLETEE ::: .: : :. :....:. .:...:::. :. :.. :.:.... :.: .. XP_016 QICGAEIFVGVAPEQPQNLSCIQKGEQGTVACTWERGRDTHLYTEYTLQLSGPKNLTWQK 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE2 EQQYLTSSY----INISTDSLQGGKKYLVWVQAANALGMEESKQLQIHLDDIVIPSAAVI . . . .: ::.. .: .. .. . : :.:.:: : . . ::: : XP_016 QCKDIYCDYLDFGINLTPESPES--NFTAKVTAVNSLGSSSSLPSTFTFLDIVRPLPPWD 180 190 200 210 220 230 240 250 260 270 280 pF1KE2 SRAETINATVPKTIIYWDSQTTIEKVSCEMRYKATTNQTWNVKEFDTNFTYVQ--QSEFY : . .:.: . .:: .. . . ..::. .... ::. .: : .. .. . XP_016 IRIKFQKASVSRCTLYWRDEGLV--LLNRLRYRPSNSRLWNM----VNVTKAKGRHDLLD 230 240 250 260 270 280 290 300 310 320 330 340 pF1KE2 LEPNIKYVFQVRCQ-ETGKRYWQPWSSPFFHKTPETVPQVTSKAFQHDTWNSGLTVASIS :.: .: ::. . . : :. :: . .::: : XP_016 LKPFTEYEFQISSKLHLYKGSWSDWSESLRAQTPEEEPTGMLDVWYMKRHIDYSRQQISL 290 300 310 320 330 340 350 360 370 380 390 400 pF1KE2 TGHLTSDNRGDIGLLLGMIVFAVMLSILSLIGIFNRSFRTGIKRRILLLIPKWLYEDIPN XP_016 FWKNLSVSEARGKILHYQVTLQELTGGKAMTQNITGHTSWTTVIPRTGNWAVAVSAANSK 350 360 370 380 390 400 >>NP_001245143 (OMIM: 601642) interleukin-12 receptor su (659 aa) initn: 226 init1: 132 opt: 307 Z-score: 334.8 bits: 72.2 E(85289): 6.6e-12 Smith-Waterman score: 307; 23.5% identity (56.0% similar) in 327 aa overlap (12-320:10-321) 10 20 30 40 50 pF1KE2 MNQVTIQWDAVIALYILFSWCHGGITNINCS-GHIWVEPATIFKMGMNISIYCQAAIKNC .:......: :. : . :.:. .. .: ...: : . NP_001 MAHTFRGCSLAFMFIITWLLIKAKIDACKRGDVTVKPSHVILLGSTVNITC-----SL 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 QPRK--LHFYKNG--IKERFQITRINKTTARLWYKNF--LEPHASMY-CTAECPKHFQET .::. .:. . . : .:. ::: .. .. : .... : : . .: NP_001 KPRQGCFHYSRRNKLILYKFD-RRINFHHGHSLNSQVTGLPLGTTLFVCKLACINS-DEI 60 70 80 90 100 110 120 130 140 150 160 pF1KE2 LICGKDISSGYPPDIPDEVTCVIYEYSGNMTCTWNAGKLTYIDTKYVVHV---KSLETEE ::: .: : :. :....:. .:...:::. :. :.. :.:.... :.: .. NP_001 QICGAEIFVGVAPEQPQNLSCIQKGEQGTVACTWERGRDTHLYTEYTLQLSGPKNLTWQK 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE2 EQQYLTSSY----INISTDSLQGGKKYLVWVQAANALGMEESKQLQIHLDDIVIPSAAVI . . . .: ::.. .: .. .. . : :.:.:: : . . ::: : NP_001 QCKDIYCDYLDFGINLTPESPES--NFTAKVTAVNSLGSSSSLPSTFTFLDIVRPLPPWD 180 190 200 210 220 230 240 250 260 270 280 pF1KE2 SRAETINATVPKTIIYWDSQTTIEKVSCEMRYKATTNQTWNVKEFDTNFTYVQ--QSEFY : . .:.: . .:: .. . . ..::. .... ::. .: : .. .. . NP_001 IRIKFQKASVSRCTLYWRDEGLV--LLNRLRYRPSNSRLWNM----VNVTKAKGRHDLLD 230 240 250 260 270 280 290 300 310 320 330 340 pF1KE2 LEPNIKYVFQVRCQ-ETGKRYWQPWSSPFFHKTPETVPQVTSKAFQHDTWNSGLTVASIS :.: .: ::. . . : :. :: . .::: : NP_001 LKPFTEYEFQISSKLHLYKGSWSDWSESLRAQTPEEEPTGMLDVWYMKRHIDYSRQQISL 290 300 310 320 330 340 350 360 370 380 390 400 pF1KE2 TGHLTSDNRGDIGLLLGMIVFAVMLSILSLIGIFNRSFRTGIKRRILLLIPKWLYEDIPN NP_001 FWKNLSVSEARGKILHYQVTLQELTGGKAMTQNITGHTSWTTVIPRTGNWAVAVSAANSK 350 360 370 380 390 400 >>XP_016856691 (OMIM: 601642) PREDICTED: interleukin-12 (700 aa) initn: 226 init1: 132 opt: 307 Z-score: 334.4 bits: 72.2 E(85289): 6.9e-12 Smith-Waterman score: 307; 23.5% identity (56.0% similar) in 327 aa overlap (12-320:10-321) 10 20 30 40 50 pF1KE2 MNQVTIQWDAVIALYILFSWCHGGITNINCS-GHIWVEPATIFKMGMNISIYCQAAIKNC .:......: :. : . :.:. .. .: ...: : . XP_016 MAHTFRGCSLAFMFIITWLLIKAKIDACKRGDVTVKPSHVILLGSTVNITC-----SL 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 QPRK--LHFYKNG--IKERFQITRINKTTARLWYKNF--LEPHASMY-CTAECPKHFQET .::. .:. . . : .:. ::: .. .. : .... : : . .: XP_016 KPRQGCFHYSRRNKLILYKFD-RRINFHHGHSLNSQVTGLPLGTTLFVCKLACINS-DEI 60 70 80 90 100 110 120 130 140 150 160 pF1KE2 LICGKDISSGYPPDIPDEVTCVIYEYSGNMTCTWNAGKLTYIDTKYVVHV---KSLETEE ::: .: : :. :....:. .:...:::. :. :.. :.:.... :.: .. XP_016 QICGAEIFVGVAPEQPQNLSCIQKGEQGTVACTWERGRDTHLYTEYTLQLSGPKNLTWQK 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE2 EQQYLTSSY----INISTDSLQGGKKYLVWVQAANALGMEESKQLQIHLDDIVIPSAAVI . . . .: ::.. .: .. .. . : :.:.:: : . . ::: : XP_016 QCKDIYCDYLDFGINLTPESPES--NFTAKVTAVNSLGSSSSLPSTFTFLDIVRPLPPWD 180 190 200 210 220 230 240 250 260 270 280 pF1KE2 SRAETINATVPKTIIYWDSQTTIEKVSCEMRYKATTNQTWNVKEFDTNFTYVQ--QSEFY : . .:.: . .:: .. . . ..::. .... ::. .: : .. .. . XP_016 IRIKFQKASVSRCTLYWRDEGLV--LLNRLRYRPSNSRLWNM----VNVTKAKGRHDLLD 230 240 250 260 270 280 290 300 310 320 330 340 pF1KE2 LEPNIKYVFQVRCQ-ETGKRYWQPWSSPFFHKTPETVPQVTSKAFQHDTWNSGLTVASIS :.: .: ::. . . : :. :: . .::: : XP_016 LKPFTEYEFQISSKLHLYKGSWSDWSESLRAQTPEEEPTGMLDVWYMKRHIDYSRQQISL 290 300 310 320 330 340 350 360 370 380 390 400 pF1KE2 TGHLTSDNRGDIGLLLGMIVFAVMLSILSLIGIFNRSFRTGIKRRILLLIPKWLYEDIPN XP_016 FWKNLSVSEARGKILHYQVTLQELTGGKAMTQNITGHTSWTTVIPRTGNWAVAVSAANSK 350 360 370 380 390 400 629 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 19:17:04 2016 done: Sun Nov 6 19:17:06 2016 Total Scan time: 10.440 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]