FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3761, 552 aa 1>>>pF1KE3761 552 - 552 aa - 552 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.3485+/-0.000608; mu= -0.6483+/- 0.037 mean_var=512.4516+/-116.743, 0's: 0 Z-trim(116.1): 2000 B-trim: 650 in 1/51 Lambda= 0.056656 statistics sampled from 24391 (27011) to 24391 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.667), E-opt: 0.2 (0.317), width: 16 Scan time: 7.650 The best scores are: opt bits E(85289) NP_006243 (OMIM: 600497) 5'-AMP-activated protein ( 552) 3703 318.6 3.2e-86 XP_016857181 (OMIM: 600497) PREDICTED: 5'-AMP-acti ( 462) 3115 270.4 8.5e-72 XP_016857182 (OMIM: 600497) PREDICTED: 5'-AMP-acti ( 462) 3115 270.4 8.5e-72 XP_016857183 (OMIM: 600497) PREDICTED: 5'-AMP-acti ( 462) 3115 270.4 8.5e-72 NP_006242 (OMIM: 602739) 5'-AMP-activated protein ( 559) 2829 247.2 1e-64 XP_016865114 (OMIM: 602739) PREDICTED: 5'-AMP-acti ( 533) 2630 230.9 7.9e-60 NP_996790 (OMIM: 602739) 5'-AMP-activated protein ( 574) 2172 193.5 1.5e-48 XP_016865113 (OMIM: 602739) PREDICTED: 5'-AMP-acti ( 548) 2150 191.7 5.2e-48 XP_006714545 (OMIM: 602739) PREDICTED: 5'-AMP-acti ( 301) 1309 122.5 1.9e-27 NP_056006 (OMIM: 608973) serine/threonine-protein ( 926) 977 96.1 5e-19 NP_775490 (OMIM: 605705,616341) serine/threonine-p ( 783) 970 95.5 6.8e-19 XP_011527776 (OMIM: 605705,616341) PREDICTED: seri ( 734) 921 91.4 1e-17 NP_003948 (OMIM: 609236) serine/threonine-protein ( 668) 909 90.4 2e-17 NP_001243558 (OMIM: 609236) serine/threonine-prote ( 674) 909 90.4 2e-17 XP_005253275 (OMIM: 609236) PREDICTED: serine/thre ( 720) 909 90.4 2.1e-17 NP_001243556 (OMIM: 609236) serine/threonine-prote ( 736) 909 90.4 2.1e-17 XP_006718437 (OMIM: 609236) PREDICTED: serine/thre ( 758) 909 90.5 2.1e-17 NP_115806 (OMIM: 609235) serine/threonine-protein ( 778) 909 90.5 2.1e-17 XP_016874025 (OMIM: 609236) PREDICTED: serine/thre ( 858) 909 90.5 2.3e-17 XP_016874022 (OMIM: 609236) PREDICTED: serine/thre ( 880) 909 90.6 2.3e-17 XP_005267700 (OMIM: 602678) PREDICTED: MAP/microtu ( 643) 902 89.8 2.9e-17 NP_002367 (OMIM: 602678) MAP/microtubule affinity- ( 729) 902 89.9 3.1e-17 XP_005267698 (OMIM: 602678) PREDICTED: MAP/microtu ( 738) 902 89.9 3.1e-17 XP_006720209 (OMIM: 602678) PREDICTED: MAP/microtu ( 739) 902 89.9 3.1e-17 NP_001122391 (OMIM: 602678) MAP/microtubule affini ( 744) 902 89.9 3.1e-17 NP_001122390 (OMIM: 602678) MAP/microtubule affini ( 753) 902 89.9 3.1e-17 XP_011541028 (OMIM: 614776) PREDICTED: serine/thre ( 660) 900 89.6 3.3e-17 XP_016872913 (OMIM: 614776) PREDICTED: serine/thre (1213) 904 90.4 3.6e-17 NP_001268678 (OMIM: 614776) serine/threonine-prote (1261) 904 90.4 3.7e-17 XP_005271539 (OMIM: 614776) PREDICTED: serine/thre (1321) 904 90.4 3.8e-17 XP_005271541 (OMIM: 614776) PREDICTED: serine/thre (1261) 900 90.1 4.6e-17 XP_011541024 (OMIM: 614776) PREDICTED: serine/thre (1309) 900 90.1 4.7e-17 NP_079440 (OMIM: 614776) serine/threonine-protein (1321) 900 90.1 4.7e-17 XP_011541023 (OMIM: 614776) PREDICTED: serine/thre (1369) 900 90.1 4.8e-17 XP_005271538 (OMIM: 614776) PREDICTED: serine/thre (1369) 900 90.1 4.8e-17 NP_001156769 (OMIM: 600526) serine/threonine-prote ( 709) 886 88.5 7.5e-17 NP_004945 (OMIM: 600526) serine/threonine-protein ( 724) 886 88.5 7.6e-17 XP_011543100 (OMIM: 600526) PREDICTED: serine/thre ( 729) 886 88.5 7.6e-17 XP_016872800 (OMIM: 600526) PREDICTED: serine/thre ( 738) 886 88.6 7.6e-17 XP_011543098 (OMIM: 600526) PREDICTED: serine/thre ( 744) 886 88.6 7.7e-17 NP_059672 (OMIM: 600526) serine/threonine-protein ( 745) 886 88.6 7.7e-17 XP_011543096 (OMIM: 600526) PREDICTED: serine/thre ( 753) 886 88.6 7.7e-17 XP_016872799 (OMIM: 600526) PREDICTED: serine/thre ( 763) 886 88.6 7.8e-17 XP_011543093 (OMIM: 600526) PREDICTED: serine/thre ( 798) 886 88.6 8e-17 NP_001273055 (OMIM: 606511) serine/threonine-prote ( 780) 885 88.5 8.3e-17 XP_005273191 (OMIM: 606511) PREDICTED: serine/thre ( 781) 885 88.5 8.3e-17 XP_011507863 (OMIM: 606511) PREDICTED: serine/thre ( 788) 885 88.5 8.4e-17 NP_061120 (OMIM: 606511) serine/threonine-protein ( 795) 885 88.5 8.4e-17 NP_001273053 (OMIM: 606511) serine/threonine-prote ( 796) 885 88.5 8.4e-17 NP_001156768 (OMIM: 600526) serine/threonine-prote ( 719) 882 88.2 9.5e-17 >>NP_006243 (OMIM: 600497) 5'-AMP-activated protein kina (552 aa) initn: 3703 init1: 3703 opt: 3703 Z-score: 1669.0 bits: 318.6 E(85289): 3.2e-86 Smith-Waterman score: 3703; 100.0% identity (100.0% similar) in 552 aa overlap (1-552:1-552) 10 20 30 40 50 60 pF1KE3 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 ECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 ECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 PGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 PGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVY 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 RAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 RAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 SGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 SGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFF 490 500 510 520 530 540 550 pF1KE3 EMCASLITTLAR :::::::::::: NP_006 EMCASLITTLAR 550 >>XP_016857181 (OMIM: 600497) PREDICTED: 5'-AMP-activate (462 aa) initn: 3115 init1: 3115 opt: 3115 Z-score: 1410.0 bits: 270.4 E(85289): 8.5e-72 Smith-Waterman score: 3115; 100.0% identity (100.0% similar) in 462 aa overlap (91-552:1-462) 70 80 90 100 110 120 pF1KE3 IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF :::::::::::::::::::::::::::::: XP_016 MVMEYVSGGELFDYICKHGRVEEMEARRLF 10 20 30 130 140 150 160 170 180 pF1KE3 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA 40 50 60 70 80 90 190 200 210 220 230 240 pF1KE3 APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS 100 110 120 130 140 150 250 260 270 280 290 300 pF1KE3 VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKF 160 170 180 190 200 210 310 320 330 340 350 360 pF1KE3 ECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIP 220 230 240 250 260 270 370 380 390 400 410 420 pF1KE3 PGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVY 280 290 300 310 320 330 430 440 450 460 470 480 pF1KE3 RAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQR 340 350 360 370 380 390 490 500 510 520 530 540 pF1KE3 SGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFF 400 410 420 430 440 450 550 pF1KE3 EMCASLITTLAR :::::::::::: XP_016 EMCASLITTLAR 460 >>XP_016857182 (OMIM: 600497) PREDICTED: 5'-AMP-activate (462 aa) initn: 3115 init1: 3115 opt: 3115 Z-score: 1410.0 bits: 270.4 E(85289): 8.5e-72 Smith-Waterman score: 3115; 100.0% identity (100.0% similar) in 462 aa overlap (91-552:1-462) 70 80 90 100 110 120 pF1KE3 IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF :::::::::::::::::::::::::::::: XP_016 MVMEYVSGGELFDYICKHGRVEEMEARRLF 10 20 30 130 140 150 160 170 180 pF1KE3 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA 40 50 60 70 80 90 190 200 210 220 230 240 pF1KE3 APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS 100 110 120 130 140 150 250 260 270 280 290 300 pF1KE3 VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKF 160 170 180 190 200 210 310 320 330 340 350 360 pF1KE3 ECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIP 220 230 240 250 260 270 370 380 390 400 410 420 pF1KE3 PGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVY 280 290 300 310 320 330 430 440 450 460 470 480 pF1KE3 RAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQR 340 350 360 370 380 390 490 500 510 520 530 540 pF1KE3 SGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFF 400 410 420 430 440 450 550 pF1KE3 EMCASLITTLAR :::::::::::: XP_016 EMCASLITTLAR 460 >>XP_016857183 (OMIM: 600497) PREDICTED: 5'-AMP-activate (462 aa) initn: 3115 init1: 3115 opt: 3115 Z-score: 1410.0 bits: 270.4 E(85289): 8.5e-72 Smith-Waterman score: 3115; 100.0% identity (100.0% similar) in 462 aa overlap (91-552:1-462) 70 80 90 100 110 120 pF1KE3 IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF :::::::::::::::::::::::::::::: XP_016 MVMEYVSGGELFDYICKHGRVEEMEARRLF 10 20 30 130 140 150 160 170 180 pF1KE3 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA 40 50 60 70 80 90 190 200 210 220 230 240 pF1KE3 APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS 100 110 120 130 140 150 250 260 270 280 290 300 pF1KE3 VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKF 160 170 180 190 200 210 310 320 330 340 350 360 pF1KE3 ECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIP 220 230 240 250 260 270 370 380 390 400 410 420 pF1KE3 PGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVY 280 290 300 310 320 330 430 440 450 460 470 480 pF1KE3 RAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQR 340 350 360 370 380 390 490 500 510 520 530 540 pF1KE3 SGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFF 400 410 420 430 440 450 550 pF1KE3 EMCASLITTLAR :::::::::::: XP_016 EMCASLITTLAR 460 >>NP_006242 (OMIM: 602739) 5'-AMP-activated protein kina (559 aa) initn: 2851 init1: 2081 opt: 2829 Z-score: 1282.8 bits: 247.2 E(85289): 1e-64 Smith-Waterman score: 2829; 76.3% identity (90.1% similar) in 553 aa overlap (2-552:13-559) 10 20 30 40 pF1KE3 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNR :::::::::::::::.::::::::::::::.:.:.::::::::::::: NP_006 MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNR 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE3 QKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHG ::::::::::::.::::::::::::::::::::::::.:.::::::::::::::::::.: NP_006 QKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNG 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE3 RVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF :..: :.:::::::::.::::::::::::::::::::::::::::::::::::::::::: NP_006 RLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE3 LRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGG :::::::::::::::::::::::::::::: ::::::::::::::::.::::::::: : NP_006 LRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDG 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE3 VFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVID .:: :.::: :: .:: :::::::.:::::::::::::::::::.:::::::::....:: NP_006 IFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMID 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE3 DEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSG :::.:::::::::.: ::.. ::. . :: ::::::::::::::::.:..::::.:::. NP_006 DEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPD- 310 320 330 340 350 350 360 370 380 390 400 pF1KE3 SFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQ ::.:: :. .:::::.: :.:..:.:: :: :: : : .:.::::::::::: NP_006 SFLDDH--HL---TRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQ 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE3 SKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDF :.: :::::: ::.::::.:::::: :.::::::::::..: ::::::: ::.:.::::: NP_006 SRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDF 420 430 440 450 460 470 470 480 490 500 510 520 pF1KE3 KSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSV- .:::::..: .::..::::: :... . . : ... :...: :::.:.:. : : NP_006 RSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVD 480 490 500 510 520 530 530 540 550 pF1KE3 -SPRLGSHTMDFFEMCASLITTLAR .:: ::::..::::::.:: ::. NP_006 LTPRPGSHTIEFFEMCANLIKILAQ 540 550 >>XP_016865114 (OMIM: 602739) PREDICTED: 5'-AMP-activate (533 aa) initn: 2652 init1: 1882 opt: 2630 Z-score: 1195.1 bits: 230.9 E(85289): 7.9e-60 Smith-Waterman score: 2630; 75.1% identity (89.5% similar) in 523 aa overlap (32-552:17-533) 10 20 30 40 50 60 pF1KE3 AEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKI .:.:.::::::::::::::::::::::::: XP_016 MQVKNIRKLPCQIIQSVGKHELTGHKVAVKILNRQKIRSLDVVGKI 10 20 30 40 70 80 90 100 110 120 pF1KE3 KREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ .::::::::::::::::::::::::.:.::::::::::::::::::.::..: :.::::: XP_016 RREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQ 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE3 QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA ::::.::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE3 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSV :::::::::::::::::: ::::::::::::::::.::::::::: :.:: :.::: :: XP_016 PEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSV 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE3 ATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFE .:: :::::::.:::::::::::::::::::.:::::::::....:::::.:::::::: XP_016 ISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFE 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE3 CTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPP :.: ::.. ::. . :: ::::::::::::::::.:..::::.:::. ::.:: :. XP_016 CSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPD-SFLDD--HHLT- 290 300 310 320 330 340 370 380 390 400 410 420 pF1KE3 GLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYR .:::::.: :.:..:.:: :: :: : : .:.::::::::::::.: :::::: : XP_016 --RPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCR 350 360 370 380 390 400 430 440 450 460 470 480 pF1KE3 AMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRS :.::::.:::::: :.::::::::::..: ::::::: ::.:.:::::.:::::..: .: XP_016 AIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKS 410 420 430 440 450 460 490 500 510 520 530 pF1KE3 GSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSV--SPRLGSHTMDF :..::::: :... . . : ... :...: :::.:.:. : : .:: ::::..: XP_016 GTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPGSHTIEF 470 480 490 500 510 520 540 550 pF1KE3 FEMCASLITTLAR :::::.:: ::. XP_016 FEMCANLIKILAQ 530 >>NP_996790 (OMIM: 602739) 5'-AMP-activated protein kina (574 aa) initn: 2837 init1: 1392 opt: 2172 Z-score: 992.5 bits: 193.5 E(85289): 1.5e-48 Smith-Waterman score: 2789; 74.3% identity (87.7% similar) in 568 aa overlap (2-552:13-574) 10 20 30 40 pF1KE3 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNR :::::::::::::::.::::::::::::::.:.:.::::::::::::: NP_996 MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNR 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE3 QKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHG ::::::::::::.::::::::::::::::::::::::.:.::::::::::::::::::.: NP_996 QKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNG 70 80 90 100 110 120 110 120 130 140 150 pF1KE3 R---------------VEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAK : ..: :.:::::::::.:::::::::::::::::::::::::::: NP_996 RKSDVPGVVKTGSTKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAK 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE3 IADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPF ::::::::::::::::::::::::::::::::::::::::::::: :::::::::::::: NP_996 IADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPF 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE3 DDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPS ::.::::::::: :.:: :.::: :: .:: :::::::.:::::::::::::::::::. NP_996 DDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPK 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE3 YLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIM :::::::::....:::::.:::::::::.: ::.. ::. . :: ::::::::::::::: NP_996 YLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIM 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE3 NQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKS :.:..::::.:::. ::.:: :. .:::::.: :.:..:.:: :: :: : : NP_996 NEAKDFYLATSPPD-SFLDDH--HL---TRPHPERVPFLVAETPRARHTLDELNPQKSKH 370 380 390 400 410 400 410 420 430 440 450 pF1KE3 LAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMS .:.::::::::::::.: :::::: ::.::::.:::::: :.::::::::::..: ::: NP_996 QGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMS 420 430 440 450 460 470 460 470 480 490 500 510 pF1KE3 LQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSG :::: ::.:.:::::.:::::..: .::..::::: :... . . : ... :...: NP_996 LQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEV 480 490 500 510 520 530 520 530 540 550 pF1KE3 SLTGSLTGSTLSSV--SPRLGSHTMDFFEMCASLITTLAR :::.:.:. : : .:: ::::..::::::.:: ::. NP_996 SLTSSVTSLDSSPVDLTPRPGSHTIEFFEMCANLIKILAQ 540 550 560 570 >>XP_016865113 (OMIM: 602739) PREDICTED: 5'-AMP-activate (548 aa) initn: 2638 init1: 1392 opt: 2150 Z-score: 983.0 bits: 191.7 E(85289): 5.2e-48 Smith-Waterman score: 2590; 73.0% identity (87.0% similar) in 538 aa overlap (32-552:17-548) 10 20 30 40 50 60 pF1KE3 AEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKI .:.:.::::::::::::::::::::::::: XP_016 MQVKNIRKLPCQIIQSVGKHELTGHKVAVKILNRQKIRSLDVVGKI 10 20 30 40 70 80 90 100 110 pF1KE3 KREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR----------- .::::::::::::::::::::::::.:.::::::::::::::::::.:: XP_016 RREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTG 50 60 70 80 90 100 120 130 140 150 160 pF1KE3 ----VEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSD ..: :.:::::::::.:::::::::::::::::::::::::::::::::::::::: XP_016 STKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSD 110 120 130 140 150 160 170 180 190 200 210 220 pF1KE3 GEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKI ::::::::::::::::::::::::::::::::: ::::::::::::::::.::::::::: XP_016 GEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKI 170 180 190 200 210 220 230 240 250 260 270 280 pF1KE3 RGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDAN :.:: :.::: :: .:: :::::::.:::::::::::::::::::.:::::::::... XP_016 CDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSST 230 240 250 260 270 280 290 300 310 320 330 340 pF1KE3 VIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSP .:::::.:::::::::.: ::.. ::. . :: ::::::::::::::::.:..::::.:: XP_016 MIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSP 290 300 310 320 330 340 350 360 370 380 390 400 pF1KE3 PSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGI :. ::.:: :. .:::::.: :.:..:.:: :: :: : : .:.:::::::: XP_016 PD-SFLDD--HHLT---RPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGI 350 360 370 380 390 400 410 420 430 440 450 460 pF1KE3 RSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYL ::::.: :::::: ::.::::.:::::: :.::::::::::..: ::::::: ::.:.:: XP_016 RSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYL 410 420 430 440 450 460 470 480 490 500 510 520 pF1KE3 LDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLS :::.:::::..: .::..::::: :... . . : ... :...: :::.:.:. : XP_016 LDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSS 470 480 490 500 510 520 530 540 550 pF1KE3 SV--SPRLGSHTMDFFEMCASLITTLAR : .:: ::::..::::::.:: ::. XP_016 PVDLTPRPGSHTIEFFEMCANLIKILAQ 530 540 >>XP_006714545 (OMIM: 602739) PREDICTED: 5'-AMP-activate (301 aa) initn: 1331 init1: 646 opt: 1309 Z-score: 613.9 bits: 122.5 E(85289): 1.9e-27 Smith-Waterman score: 1309; 65.1% identity (84.7% similar) in 307 aa overlap (248-552:1-301) 220 230 240 250 260 270 pF1KE3 HVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLF ::::::.:::::::::::::::::::.::: XP_006 MLQVDPMKRATIKDIREHEWFKQDLPKYLF 10 20 30 280 290 300 310 320 330 pF1KE3 PEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQA ::::::....:::::.:::::::::.: ::.. ::. . :: ::::::::::::::::.: XP_006 PEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEA 40 50 60 70 80 90 340 350 360 370 380 390 pF1KE3 SEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAV ..::::.:::. ::.:: :. .:::::.: :.:..:.:: :: :: : : .: XP_006 KDFYLATSPPD-SFLDDH--HLT---RPHPERVPFLVAETPRARHTLDELNPQKSKHQGV 100 110 120 130 140 400 410 420 430 440 450 pF1KE3 KKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQL .::::::::::::.: :::::: ::.::::.:::::: :.::::::::::..: :::::: XP_006 RKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQL 150 160 170 180 190 200 460 470 480 490 500 510 pF1KE3 YLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLT : ::.:.:::::.:::::..: .::..::::: :... . . : ... :...: ::: XP_006 YQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLT 210 220 230 240 250 260 520 530 540 550 pF1KE3 GSLTGSTLSSV--SPRLGSHTMDFFEMCASLITTLAR .:.:. : : .:: ::::..::::::.:: ::. XP_006 SSVTSLDSSPVDLTPRPGSHTIEFFEMCANLIKILAQ 270 280 290 300 >>NP_056006 (OMIM: 608973) serine/threonine-protein kina (926 aa) initn: 945 init1: 826 opt: 977 Z-score: 462.6 bits: 96.1 E(85289): 5e-19 Smith-Waterman score: 977; 43.4% identity (74.6% similar) in 346 aa overlap (1-340:3-344) 10 20 30 40 50 pF1KE3 MAEKQKH--DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLD ::. .: : :..: : . ::: :.:. ::.:.:..: .::.::...... ... NP_056 MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE3 VVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEA . :: ::.: .:.. ::::::::::. : . ...: ::...::.:::. .:::..: :: NP_056 LE-KIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEA 70 80 90 100 110 120 130 140 150 160 170 pF1KE3 RRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGS :: : :::::::::: . .:::::: ::.::: .:: ::::::..:....::.: : ::: NP_056 RRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGS 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE3 PNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEY : ::::::. :. : ::..:::: ::.::.:.::.:::: .: : ... : : :: . NP_056 PPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYF 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE3 LNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLP---SYLFPEDPSYDANVID-DEA .... :. .:: .:: :: :: .:.::.:. ..: :.:.. . .. . .: NP_056 MSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQ 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE3 VKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFM : .. ... ......:: .. ...:. : :... :. .. : : NP_056 VLRLMHSLGIDQQKTIESL-QNKSYNHFAAIYFLLVE--RLKSHRSSFPVEQRLDGRQRR 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE3 DDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKP NP_056 PSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEE 360 370 380 390 400 410 552 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 07:08:38 2016 done: Sun Nov 6 07:08:39 2016 Total Scan time: 7.650 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]