FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2134, 858 aa 1>>>pF1KE2134 858 - 858 aa - 858 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.2131+/-0.000543; mu= 15.9585+/- 0.033 mean_var=134.9191+/-28.899, 0's: 0 Z-trim(108.9): 373 B-trim: 219 in 1/50 Lambda= 0.110417 statistics sampled from 16580 (17042) to 16580 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.531), E-opt: 0.2 (0.2), width: 16 Scan time: 9.070 The best scores are: opt bits E(85289) XP_016857697 (OMIM: 601744,603031,608556,615557) P ( 858) 5692 920.1 0 XP_006711568 (OMIM: 601744,603031,608556,615557) P ( 858) 5692 920.1 0 XP_005273300 (OMIM: 601744,603031,608556,615557) P ( 858) 5692 920.1 0 XP_005273298 (OMIM: 601744,603031,608556,615557) P ( 858) 5692 920.1 0 XP_005273299 (OMIM: 601744,603031,608556,615557) P ( 858) 5692 920.1 0 XP_011508239 (OMIM: 601744,603031,608556,615557) P ( 858) 5692 920.1 0 NP_003259 (OMIM: 601744,603031,608556,615557) toll ( 858) 5692 920.1 0 XP_006711569 (OMIM: 601744,603031,608556,615557) P ( 858) 5692 920.1 0 XP_006711567 (OMIM: 601744,603031,608556,615557) P ( 858) 5692 920.1 0 NP_619542 (OMIM: 300366) toll-like receptor 8 isof (1041) 653 117.5 3.2e-25 XP_011543831 (OMIM: 300366) PREDICTED: toll-like r (1059) 653 117.5 3.2e-25 XP_011543832 (OMIM: 300366) PREDICTED: toll-like r (1059) 653 117.5 3.2e-25 NP_057694 (OMIM: 300366) toll-like receptor 8 isof (1059) 653 117.5 3.2e-25 NP_057646 (OMIM: 300365) toll-like receptor 7 prec (1049) 626 113.2 6.3e-24 NP_059138 (OMIM: 605474) toll-like receptor 9 prec (1032) 521 96.5 6.8e-19 XP_016864066 (OMIM: 603029,609423) PREDICTED: toll ( 627) 498 92.6 6.1e-18 XP_011512046 (OMIM: 601194,613223) PREDICTED: toll ( 786) 449 84.9 1.6e-15 XP_011512044 (OMIM: 601194,613223) PREDICTED: toll ( 786) 449 84.9 1.6e-15 XP_005262719 (OMIM: 601194,613223) PREDICTED: toll ( 786) 449 84.9 1.6e-15 XP_016864061 (OMIM: 601194,613223) PREDICTED: toll ( 786) 449 84.9 1.6e-15 NP_003254 (OMIM: 601194,613223) toll-like receptor ( 786) 449 84.9 1.6e-15 XP_011512045 (OMIM: 601194,613223) PREDICTED: toll ( 786) 449 84.9 1.6e-15 XP_016864060 (OMIM: 601194,613223) PREDICTED: toll ( 786) 449 84.9 1.6e-15 XP_011512047 (OMIM: 601194,613223) PREDICTED: toll ( 786) 449 84.9 1.6e-15 NP_006059 (OMIM: 605403) toll-like receptor 6 prec ( 796) 401 77.3 3.2e-13 XP_011511915 (OMIM: 605403) PREDICTED: toll-like r ( 796) 401 77.3 3.2e-13 XP_011511914 (OMIM: 605403) PREDICTED: toll-like r ( 796) 401 77.3 3.2e-13 XP_011511916 (OMIM: 605403) PREDICTED: toll-like r ( 796) 401 77.3 3.2e-13 XP_005262694 (OMIM: 605403) PREDICTED: toll-like r ( 796) 401 77.3 3.2e-13 NP_003257 (OMIM: 603030,611488) toll-like receptor ( 799) 388 75.2 1.4e-12 NP_612564 (OMIM: 603030,611488) toll-like receptor ( 839) 388 75.2 1.4e-12 NP_004479 (OMIM: 173511) platelet glycoprotein V p ( 560) 356 69.9 3.6e-11 NP_001305722 (OMIM: 246300,603028,607948) toll-lik ( 784) 357 70.2 4.1e-11 XP_016864064 (OMIM: 246300,603028,607948) PREDICTE ( 784) 357 70.2 4.1e-11 NP_001305720 (OMIM: 246300,603028,607948) toll-lik ( 784) 357 70.2 4.1e-11 NP_001305719 (OMIM: 246300,603028,607948) toll-lik ( 784) 357 70.2 4.1e-11 XP_016864062 (OMIM: 246300,603028,607948) PREDICTE ( 784) 357 70.2 4.1e-11 NP_001305716 (OMIM: 246300,603028,607948) toll-lik ( 784) 357 70.2 4.1e-11 XP_011530517 (OMIM: 246300,603028,607948) PREDICTE ( 784) 357 70.2 4.1e-11 NP_003255 (OMIM: 246300,603028,607948) toll-like r ( 784) 357 70.2 4.1e-11 XP_011530518 (OMIM: 246300,603028,607948) PREDICTE ( 784) 357 70.2 4.1e-11 XP_016864065 (OMIM: 246300,603028,607948) PREDICTE ( 784) 357 70.2 4.1e-11 NP_001305724 (OMIM: 246300,603028,607948) toll-lik ( 784) 357 70.2 4.1e-11 NP_001305725 (OMIM: 246300,603028,607948) toll-lik ( 784) 357 70.2 4.1e-11 XP_016864063 (OMIM: 246300,603028,607948) PREDICTE ( 784) 357 70.2 4.1e-11 NP_001305718 (OMIM: 246300,603028,607948) toll-lik ( 784) 357 70.2 4.1e-11 NP_004961 (OMIM: 601489,615961) insulin-like growt ( 605) 328 65.5 8.4e-10 NP_001139478 (OMIM: 601489,615961) insulin-like gr ( 643) 328 65.5 8.8e-10 NP_001004432 (OMIM: 609794) leucine-rich repeat an ( 593) 323 64.7 1.4e-09 NP_612567 (OMIM: 603030,611488) toll-like receptor ( 639) 315 63.5 3.7e-09 >>XP_016857697 (OMIM: 601744,603031,608556,615557) PREDI (858 aa) initn: 5692 init1: 5692 opt: 5692 Z-score: 4913.0 bits: 920.1 E(85289): 0 Smith-Waterman score: 5692; 99.8% identity (100.0% similar) in 858 aa overlap (1-858:1-858) 10 20 30 40 50 60 pF1KE2 MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 VTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 LFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 QIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 DITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 LSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFISWLNHTNVT :::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::: XP_016 LSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVT 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 IAGPPADIYCVYPDSLSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTV :::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::: XP_016 IAGPPADIYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTV 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 TKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYS 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 DQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 SDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKE 790 800 810 820 830 840 850 pF1KE2 KEKKKDNNIPLQTVATIS :::::::::::::::::: XP_016 KEKKKDNNIPLQTVATIS 850 >>XP_006711568 (OMIM: 601744,603031,608556,615557) PREDI (858 aa) initn: 5692 init1: 5692 opt: 5692 Z-score: 4913.0 bits: 920.1 E(85289): 0 Smith-Waterman score: 5692; 99.8% identity (100.0% similar) in 858 aa overlap (1-858:1-858) 10 20 30 40 50 60 pF1KE2 MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 VTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 LFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 QIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 DITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 LSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFISWLNHTNVT :::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::: XP_006 LSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVT 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 IAGPPADIYCVYPDSLSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTV :::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::: XP_006 IAGPPADIYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTV 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 TKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYS 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 DQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 SDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKE 790 800 810 820 830 840 850 pF1KE2 KEKKKDNNIPLQTVATIS :::::::::::::::::: XP_006 KEKKKDNNIPLQTVATIS 850 >>XP_005273300 (OMIM: 601744,603031,608556,615557) PREDI (858 aa) initn: 5692 init1: 5692 opt: 5692 Z-score: 4913.0 bits: 920.1 E(85289): 0 Smith-Waterman score: 5692; 99.8% identity (100.0% similar) in 858 aa overlap (1-858:1-858) 10 20 30 40 50 60 pF1KE2 MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 VTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 LFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 QIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 DITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 LSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFISWLNHTNVT :::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::: XP_005 LSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVT 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 IAGPPADIYCVYPDSLSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTV :::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::: XP_005 IAGPPADIYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTV 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 TKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYS 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 DQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 SDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKE 790 800 810 820 830 840 850 pF1KE2 KEKKKDNNIPLQTVATIS :::::::::::::::::: XP_005 KEKKKDNNIPLQTVATIS 850 >>XP_005273298 (OMIM: 601744,603031,608556,615557) PREDI (858 aa) initn: 5692 init1: 5692 opt: 5692 Z-score: 4913.0 bits: 920.1 E(85289): 0 Smith-Waterman score: 5692; 99.8% identity (100.0% similar) in 858 aa overlap (1-858:1-858) 10 20 30 40 50 60 pF1KE2 MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 VTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 LFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 QIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 DITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 LSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFISWLNHTNVT :::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::: XP_005 LSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVT 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 IAGPPADIYCVYPDSLSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTV :::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::: XP_005 IAGPPADIYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTV 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 TKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYS 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 DQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 SDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKE 790 800 810 820 830 840 850 pF1KE2 KEKKKDNNIPLQTVATIS :::::::::::::::::: XP_005 KEKKKDNNIPLQTVATIS 850 >>XP_005273299 (OMIM: 601744,603031,608556,615557) PREDI (858 aa) initn: 5692 init1: 5692 opt: 5692 Z-score: 4913.0 bits: 920.1 E(85289): 0 Smith-Waterman score: 5692; 99.8% identity (100.0% similar) in 858 aa overlap (1-858:1-858) 10 20 30 40 50 60 pF1KE2 MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 VTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 LFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 QIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 DITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 LSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFISWLNHTNVT :::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::: XP_005 LSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVT 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 IAGPPADIYCVYPDSLSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTV :::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::: XP_005 IAGPPADIYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTV 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 TKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYS 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 DQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 SDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKE 790 800 810 820 830 840 850 pF1KE2 KEKKKDNNIPLQTVATIS :::::::::::::::::: XP_005 KEKKKDNNIPLQTVATIS 850 >>XP_011508239 (OMIM: 601744,603031,608556,615557) PREDI (858 aa) initn: 5692 init1: 5692 opt: 5692 Z-score: 4913.0 bits: 920.1 E(85289): 0 Smith-Waterman score: 5692; 99.8% identity (100.0% similar) in 858 aa overlap (1-858:1-858) 10 20 30 40 50 60 pF1KE2 MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 VTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 LFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 QIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 DITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 LSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFISWLNHTNVT :::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::: XP_011 LSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVT 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 IAGPPADIYCVYPDSLSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTV :::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::: XP_011 IAGPPADIYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTV 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 TKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYS 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 DQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 SDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKE 790 800 810 820 830 840 850 pF1KE2 KEKKKDNNIPLQTVATIS :::::::::::::::::: XP_011 KEKKKDNNIPLQTVATIS 850 >>NP_003259 (OMIM: 601744,603031,608556,615557) toll-lik (858 aa) initn: 5692 init1: 5692 opt: 5692 Z-score: 4913.0 bits: 920.1 E(85289): 0 Smith-Waterman score: 5692; 99.8% identity (100.0% similar) in 858 aa overlap (1-858:1-858) 10 20 30 40 50 60 pF1KE2 MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 VTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 VTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 LFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 QIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 QIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 DITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 DITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 LSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFISWLNHTNVT :::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::: NP_003 LSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVT 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 IAGPPADIYCVYPDSLSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTV :::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::: NP_003 IAGPPADIYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTV 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 TKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 TKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYS 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 DQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 DQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 SDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 SDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKE 790 800 810 820 830 840 850 pF1KE2 KEKKKDNNIPLQTVATIS :::::::::::::::::: NP_003 KEKKKDNNIPLQTVATIS 850 >>XP_006711569 (OMIM: 601744,603031,608556,615557) PREDI (858 aa) initn: 5692 init1: 5692 opt: 5692 Z-score: 4913.0 bits: 920.1 E(85289): 0 Smith-Waterman score: 5692; 99.8% identity (100.0% similar) in 858 aa overlap (1-858:1-858) 10 20 30 40 50 60 pF1KE2 MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 VTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 LFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 QIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 DITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 LSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFISWLNHTNVT :::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::: XP_006 LSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVT 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 IAGPPADIYCVYPDSLSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTV :::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::: XP_006 IAGPPADIYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTV 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 TKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYS 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 DQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 SDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKE 790 800 810 820 830 840 850 pF1KE2 KEKKKDNNIPLQTVATIS :::::::::::::::::: XP_006 KEKKKDNNIPLQTVATIS 850 >>XP_006711567 (OMIM: 601744,603031,608556,615557) PREDI (858 aa) initn: 5692 init1: 5692 opt: 5692 Z-score: 4913.0 bits: 920.1 E(85289): 0 Smith-Waterman score: 5692; 99.8% identity (100.0% similar) in 858 aa overlap (1-858:1-858) 10 20 30 40 50 60 pF1KE2 MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 VTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 LFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 QIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 DITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 LSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFISWLNHTNVT :::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::: XP_006 LSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVT 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 IAGPPADIYCVYPDSLSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTV :::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::: XP_006 IAGPPADIYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTV 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 TKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYS 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 DQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 SDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKE 790 800 810 820 830 840 850 pF1KE2 KEKKKDNNIPLQTVATIS :::::::::::::::::: XP_006 KEKKKDNNIPLQTVATIS 850 >>NP_619542 (OMIM: 300366) toll-like receptor 8 isoform (1041 aa) initn: 303 init1: 134 opt: 653 Z-score: 573.8 bits: 117.5 E(85289): 3.2e-25 Smith-Waterman score: 699; 27.1% identity (56.5% similar) in 874 aa overlap (35-847:210-1032) 10 20 30 40 50 60 pF1KE2 LDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTER-LLLSFNYIRTVTA : .:..:: : .. : :.:: . :. .. NP_619 NCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISE 180 190 200 210 220 230 70 80 90 100 pF1KE2 SSFPFLEQLQLLELGSQ-----YTP-----------LTIDKEAFRNLPNLRILDLGSSKI .: : .: ::.:... .: ..::. ::.:: .:: :.:.:... NP_619 EDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSL 240 250 260 270 280 290 110 120 130 140 150 160 pF1KE2 YFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLY-----L .. :... :: : : : : . . ... : : :::: : :.. : . NP_619 RKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINI 300 310 320 330 340 350 170 180 190 200 210 220 pF1KE2 HPSFGKLNSLKSIDFSSNQIFLVCEHELEPL-QGKTLSFFSLAANSLYSRVSVDWGKCMN .:.:: ::... . . . . : ...:: : .:: ..:. : . . .:. : .. NP_619 SRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQ---IDF-KLFQ 360 370 380 390 400 410 230 240 250 260 270 pF1KE2 PFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIM---GAGFGFHNIKDPD : : :::. .: : . .. . .. ..:..:. .:: .. : : :: NP_619 NFSN--LEIIYLSENRIS-PLVKDTRQSYANSSSFQ----RHIRKRRSTDFEF----DPH 420 430 440 450 460 280 290 300 310 320 330 pF1KE2 QNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNL .: : ..: .. ..: :.:.:. :.: :. . : .: .. NP_619 SN-FYHFTRPLIKPQCAAYG----------------KALDLSLNSIFFIGPNQFENLPDI 470 480 490 500 340 350 360 370 380 390 pF1KE2 QVLNLSYNLLGELYS-SNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDN--- :::: : ... : ..: ..:.: :.:: .:.. . . ... : :..::: : NP_619 ACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHY 510 520 530 540 550 560 400 410 420 430 pF1KE2 ---ALTTIH--FIPSIPDIF---LSGNKLVTLP-KINL-TANLIHL--SENRLENL---- : .: : :: .. .. :: :.. :: : :: . .:..: : :::. : NP_619 FRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDD 570 580 590 600 610 620 440 450 460 470 480 490 pF1KE2 DILYFLLR--VPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWD : :. . . .: : :. ::.. .. . :: .: ...:::.. . : NP_619 DNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKF-----FNWT 630 640 650 660 670 680 500 510 520 530 540 550 pF1KE2 VFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLP--ANLEILD ... . .:..: : : : : .. . ..:: : :. ::.. : . : ..:. :: NP_619 LLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLD 690 700 710 720 730 740 560 570 580 590 600 pF1KE2 ISRNQLLAPNPDVF-----VSLSVLDITHNKFICECELSTFISWLN-HTNVTIAGPP-AD .: : : . : ... ..::.:.. : : : :... : :.. : :: : : .: NP_619 LSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDIGDFRRWMDEHLNVKI--PRLVD 750 760 770 780 790 800 610 620 630 640 650 660 pF1KE2 IYCVYPDSLSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTVTKFRGFC . :. : . : :. :: : . . : : :.. :. ... :. : NP_619 VICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFI----TTMVMLAALAHHLFYWDV 810 820 830 840 850 670 680 690 700 710 720 pF1KE2 FICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFT---WVQNALLKHLDTQYSDQNR .. :.. : : . . . . . ::::. ...:: . :: : : ::. . :.: NP_619 WFIYNVCLAKV-KGYRSLSTSQTF-YDAYISYDTKDASVTDWVINELRYHLE-ESRDKNV 860 870 880 890 900 910 730 740 750 760 770 780 pF1KE2 FNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLE-AFSYAQGRCLSDL . ::.::::. :: : :....: .:.: : ...... .. : .. :: : : ... NP_619 L-LCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKS-WNFKTAFYLALQRLMDEN 920 930 940 950 960 970 790 800 810 820 830 840 pF1KE2 NSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKEKEK ...:.... . :.. .. .: . :.. :.::.. . : : . : . .: :... NP_619 MDVIIFILLEPVLQHS--QYLRLRQRICKSSILQWPDNPKAEGLFWQTLRNVVLT-ENDS 980 990 1000 1010 1020 850 pF1KE2 KKDNNIPLQTVATIS . .: NP_619 RYNNMYVDSIKQY 1030 1040 858 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 10:47:35 2016 done: Tue Nov 8 10:47:36 2016 Total Scan time: 9.070 Total Display time: 0.270 Function used was FASTA [36.3.4 Apr, 2011]