FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4237, 1047 aa 1>>>pF1KE4237 1047 - 1047 aa - 1047 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.4700+/-0.000473; mu= -0.9706+/- 0.030 mean_var=357.1152+/-75.612, 0's: 0 Z-trim(118.4): 149 B-trim: 0 in 0/58 Lambda= 0.067869 statistics sampled from 31188 (31366) to 31188 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.685), E-opt: 0.2 (0.368), width: 16 Scan time: 12.410 The best scores are: opt bits E(85289) NP_002881 (OMIM: 139150,605462,608354,608355) ras (1047) 6958 696.6 1.9e-199 XP_011541827 (OMIM: 139150,605462,608354,608355) P (1018) 5793 582.5 4e-165 NP_072179 (OMIM: 139150,605462,608354,608355) ras ( 870) 5769 580.1 1.8e-164 XP_011541829 (OMIM: 139150,605462,608354,608355) P ( 539) 3608 368.3 6.5e-101 XP_016858344 (OMIM: 606136) PREDICTED: ras GTPase- (1138) 649 78.9 1.8e-13 NP_733793 (OMIM: 606136) ras GTPase-activating pro (1280) 649 78.9 2e-13 XP_016858341 (OMIM: 606136) PREDICTED: ras GTPase- (1409) 649 79.0 2.1e-13 XP_016858340 (OMIM: 606136) PREDICTED: ras GTPase- (1412) 649 79.0 2.1e-13 NP_004832 (OMIM: 606136) ras GTPase-activating pro (1139) 642 78.2 2.9e-13 XP_005245679 (OMIM: 606136) PREDICTED: ras GTPase- (1142) 642 78.2 2.9e-13 XP_016858343 (OMIM: 606136) PREDICTED: ras GTPase- (1145) 642 78.2 2.9e-13 XP_016858342 (OMIM: 606136) PREDICTED: ras GTPase- (1234) 642 78.2 3.1e-13 XP_011508469 (OMIM: 606136) PREDICTED: ras GTPase- (1287) 642 78.3 3.2e-13 XP_011508468 (OMIM: 606136) PREDICTED: ras GTPase- (1290) 642 78.3 3.2e-13 XP_016858339 (OMIM: 606136) PREDICTED: ras GTPase- (1416) 642 78.3 3.4e-13 XP_016858338 (OMIM: 606136) PREDICTED: ras GTPase- (1419) 642 78.3 3.4e-13 XP_016869789 (OMIM: 609205) PREDICTED: disabled ho (1065) 635 77.5 4.5e-13 XP_011516573 (OMIM: 609205) PREDICTED: disabled ho (1065) 635 77.5 4.5e-13 XP_011516572 (OMIM: 609205) PREDICTED: disabled ho (1065) 635 77.5 4.5e-13 NP_619723 (OMIM: 609205) disabled homolog 2-intera (1065) 635 77.5 4.5e-13 XP_005251781 (OMIM: 609205) PREDICTED: disabled ho (1128) 635 77.5 4.7e-13 XP_011516569 (OMIM: 609205) PREDICTED: disabled ho (1131) 635 77.5 4.7e-13 NP_115941 (OMIM: 609205) disabled homolog 2-intera (1132) 635 77.5 4.7e-13 XP_016869788 (OMIM: 609205) PREDICTED: disabled ho (1141) 635 77.5 4.7e-13 XP_011516568 (OMIM: 609205) PREDICTED: disabled ho (1153) 635 77.5 4.7e-13 XP_011516567 (OMIM: 609205) PREDICTED: disabled ho (1160) 635 77.5 4.8e-13 XP_005251778 (OMIM: 609205) PREDICTED: disabled ho (1161) 635 77.5 4.8e-13 XP_016869787 (OMIM: 609205) PREDICTED: disabled ho (1164) 635 77.5 4.8e-13 XP_011516566 (OMIM: 609205) PREDICTED: disabled ho (1182) 635 77.5 4.8e-13 XP_005251776 (OMIM: 609205) PREDICTED: disabled ho (1189) 635 77.5 4.8e-13 NP_075055 (OMIM: 616561) RAS protein activator lik (1011) 559 70.0 7.5e-11 XP_011526489 (OMIM: 616561) PREDICTED: RAS protein ( 949) 533 67.5 4.2e-10 XP_011526488 (OMIM: 616561) PREDICTED: RAS protein (1008) 533 67.5 4.4e-10 XP_011526487 (OMIM: 616561) PREDICTED: RAS protein (1014) 533 67.5 4.4e-10 NP_006763 (OMIM: 603384,612621) ras/Rap GTPase-act (1343) 433 57.8 4.8e-07 XP_011533144 (OMIM: 605182) PREDICTED: ras GTPase- ( 802) 418 56.1 9.1e-07 XP_011533143 (OMIM: 605182) PREDICTED: ras GTPase- ( 802) 418 56.1 9.1e-07 NP_001307751 (OMIM: 605182) ras GTPase-activating ( 802) 418 56.1 9.1e-07 NP_031394 (OMIM: 605182) ras GTPase-activating pro ( 834) 418 56.1 9.4e-07 NP_000258 (OMIM: 162200,162210,193520,601321,60778 (2818) 412 56.1 3.3e-06 XP_016880178 (OMIM: 162200,162210,193520,601321,60 (2828) 412 56.1 3.4e-06 XP_005258041 (OMIM: 162200,162210,193520,601321,60 (2836) 412 56.1 3.4e-06 XP_006721988 (OMIM: 162200,162210,193520,601321,60 (2846) 412 56.1 3.4e-06 NP_001290175 (OMIM: 601589) ras GTPase-activating ( 853) 386 53.0 8.4e-06 XP_016862459 (OMIM: 601589) PREDICTED: ras GTPase- ( 707) 377 52.1 1.3e-05 NP_006497 (OMIM: 601589) ras GTPase-activating pro ( 849) 377 52.1 1.5e-05 NP_001290174 (OMIM: 601589) ras GTPase-activating ( 850) 377 52.1 1.5e-05 XP_011511361 (OMIM: 601589) PREDICTED: ras GTPase- ( 853) 377 52.1 1.5e-05 XP_016862458 (OMIM: 601589) PREDICTED: ras GTPase- ( 871) 377 52.1 1.6e-05 XP_016862457 (OMIM: 601589) PREDICTED: ras GTPase- ( 872) 377 52.1 1.6e-05 >>NP_002881 (OMIM: 139150,605462,608354,608355) ras GTPa (1047 aa) initn: 6958 init1: 6958 opt: 6958 Z-score: 3701.8 bits: 696.6 E(85289): 1.9e-199 Smith-Waterman score: 6958; 100.0% identity (100.0% similar) in 1047 aa overlap (1-1047:1-1047) 10 20 30 40 50 60 pF1KE4 MMAAEAGSEEGGPVTAGAGGGGAAAGSSAYPAVCRVKIPAALPVAAAPYPGLVETGVAGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MMAAEAGSEEGGPVTAGAGGGGAAAGSSAYPAVCRVKIPAALPVAAAPYPGLVETGVAGT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 LGGGAALGSEFLGAGSVAGALGGAGLTGGGTAAGVAGAAAGVAGAAVAGPSGDMALTKLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LGGGAALGSEFLGAGSVAGALGGAGLTGGGTAAGVAGAAAGVAGAAVAGPSGDMALTKLP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 TSLLAETLGPGGGFPPLPPPPYLPPLGAGLGTVDEGDSLDGPEYEEEEVAIPLTAPPTNQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 TSLLAETLGPGGGFPPLPPPPYLPPLGAGLGTVDEGDSLDGPEYEEEEVAIPLTAPPTNQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 WYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 WYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 IGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEPVEDRRRVRAILPYTKVPDTDEIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 IGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEPVEDRRRVRAILPYTKVPDTDEIS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 FLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKISKQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 FLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKISKQE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 AYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFMMGGRYYNSIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 AYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFMMGGRYYNSIG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 DIIDHYRKEQIVEGYYLKEPVPMQDQEQVLNDTVDGKEIYNTIRRKTKDAFYKNIVKKGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 DIIDHYRKEQIVEGYYLKEPVPMQDQEQVLNDTVDGKEIYNTIRRKTKDAFYKNIVKKGY 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 LLKKGKGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGRPNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LLKKGKGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGRPNC 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 FQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKRLRQVSSLVLHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 FQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKRLRQVSSLVLHI 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE4 EEAHKLPVKHFTNPYCNIYLNSVQVAKTHAREGQNPVWSEEFVFDDLPPDINRFEITLSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 EEAHKLPVKHFTNPYCNIYLNSVQVAKTHAREGQNPVWSEEFVFDDLPPDINRFEITLSN 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE4 KTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPGSLRVRARYSMEKIMPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 KTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPGSLRVRARYSMEKIMPE 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE4 EEYSEFKELILQKELHVVYALSHVCGQDRTLLASILLRIFLHEKLESLLLCTLNDREISM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 EEYSEFKELILQKELHVVYALSHVCGQDRTLLASILLRIFLHEKLESLLLCTLNDREISM 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE4 EDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 EDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNED 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE4 VNTNLTHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 VNTNLTHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFV 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE4 FLRLICPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVNPFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 FLRLICPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVNPFI 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE4 KSNKHRMIMFLDELGNVPELPDTTEHSRTDLSRDLAALHEICVAHSDELRTLSNERGAQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 KSNKHRMIMFLDELGNVPELPDTTEHSRTDLSRDLAALHEICVAHSDELRTLSNERGAQQ 970 980 990 1000 1010 1020 1030 1040 pF1KE4 HVLKKLLAITELLQQKQNQYTKTNDVR ::::::::::::::::::::::::::: NP_002 HVLKKLLAITELLQQKQNQYTKTNDVR 1030 1040 >>XP_011541827 (OMIM: 139150,605462,608354,608355) PREDI (1018 aa) initn: 5793 init1: 5793 opt: 5793 Z-score: 3085.4 bits: 582.5 E(85289): 4e-165 Smith-Waterman score: 6692; 97.2% identity (97.2% similar) in 1047 aa overlap (1-1047:1-1018) 10 20 30 40 50 60 pF1KE4 MMAAEAGSEEGGPVTAGAGGGGAAAGSSAYPAVCRVKIPAALPVAAAPYPGLVETGVAGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MMAAEAGSEEGGPVTAGAGGGGAAAGSSAYPAVCRVKIPAALPVAAAPYPGLVETGVAGT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 LGGGAALGSEFLGAGSVAGALGGAGLTGGGTAAGVAGAAAGVAGAAVAGPSGDMALTKLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGGGAALGSEFLGAGSVAGALGGAGLTGGGTAAGVAGAAAGVAGAAVAGPSGDMALTKLP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 TSLLAETLGPGGGFPPLPPPPYLPPLGAGLGTVDEGDSLDGPEYEEEEVAIPLTAPPTNQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TSLLAETLGPGGGFPPLPPPPYLPPLGAGLGTVDEGDSLDGPEYEEEEVAIPLTAPPTNQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 WYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 IGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEPVEDRRRVRAILPYTKVPDTDEIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEPVEDRRRVRAILPYTKVPDTDEIS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 FLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKISKQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKISKQE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 AYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFMMGGRYYNSIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFMMGGRYYNSIG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 DIIDHYRKEQIVEGYYLKEPVPMQDQEQVLNDTVDGKEIYNTIRRKTKDAFYKNIVKKGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DIIDHYRKEQIVEGYYLKEPVPMQDQEQVLNDTVDGKEIYNTIRRKTKDAFYKNIVKKGY 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 LLKKGKGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGRPNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLKKGKGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGRPNC 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 FQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKRLRQVSSLVLHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKRLRQVSSLVLHI 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE4 EEAHKLPVKHFTNPYCNIYLNSVQVAKTHAREGQNPVWSEEFVFDDLPPDINRFEITLSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EEAHKLPVKHFTNPYCNIYLNSVQVAKTHAREGQNPVWSEEFVFDDLPPDINRFEITLSN 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE4 KTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPGSLRVRARYSMEKIMPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPGSLRVRARYSMEKIMPE 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE4 EEYSEFKELILQKELHVVYALSHVCGQDRTLLASILLRIFLHEKLESLLLCTLNDREISM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EEYSEFKELILQKELHVVYALSHVCGQDRTLLASILLRIFLHEKLESLLLCTLNDREISM 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE4 EDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNED 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE4 VNTNLTHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFV :::::::::::::::::::::::::::: ::: XP_011 VNTNLTHLLNILSELVEKIFMASEILPP-----------------------------GFV 850 860 870 910 920 930 940 950 960 pF1KE4 FLRLICPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVNPFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FLRLICPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVNPFI 880 890 900 910 920 930 970 980 990 1000 1010 1020 pF1KE4 KSNKHRMIMFLDELGNVPELPDTTEHSRTDLSRDLAALHEICVAHSDELRTLSNERGAQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KSNKHRMIMFLDELGNVPELPDTTEHSRTDLSRDLAALHEICVAHSDELRTLSNERGAQQ 940 950 960 970 980 990 1030 1040 pF1KE4 HVLKKLLAITELLQQKQNQYTKTNDVR ::::::::::::::::::::::::::: XP_011 HVLKKLLAITELLQQKQNQYTKTNDVR 1000 1010 >>NP_072179 (OMIM: 139150,605462,608354,608355) ras GTPa (870 aa) initn: 5769 init1: 5769 opt: 5769 Z-score: 3073.6 bits: 580.1 E(85289): 1.8e-164 Smith-Waterman score: 5769; 100.0% identity (100.0% similar) in 867 aa overlap (181-1047:4-870) 160 170 180 190 200 210 pF1KE4 GTVDEGDSLDGPEYEEEEVAIPLTAPPTNQWYHGKLDRTIAEERLRQAGKSGSYLIRESD :::::::::::::::::::::::::::::: NP_072 MKGWYHGKLDRTIAEERLRQAGKSGSYLIRESD 10 20 30 220 230 240 250 260 270 pF1KE4 RRPGSFVLSFLSQMNVVNHFRIIAMCGDYYIGGRRFSSLSDLIGYYSHVSCLLKGEKLLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_072 RRPGSFVLSFLSQMNVVNHFRIIAMCGDYYIGGRRFSSLSDLIGYYSHVSCLLKGEKLLY 40 50 60 70 80 90 280 290 300 310 320 330 pF1KE4 PVAPPEPVEDRRRVRAILPYTKVPDTDEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_072 PVAPPEPVEDRRRVRAILPYTKVPDTDEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGL 100 110 120 130 140 150 340 350 360 370 380 390 pF1KE4 IVEDLVEEVGREEDPHEGKIWFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_072 IVEDLVEEVGREEDPHEGKIWFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYF 160 170 180 190 200 210 400 410 420 430 440 450 pF1KE4 RTNENIQRFKICPTPNNQFMMGGRYYNSIGDIIDHYRKEQIVEGYYLKEPVPMQDQEQVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_072 RTNENIQRFKICPTPNNQFMMGGRYYNSIGDIIDHYRKEQIVEGYYLKEPVPMQDQEQVL 220 230 240 250 260 270 460 470 480 490 500 510 pF1KE4 NDTVDGKEIYNTIRRKTKDAFYKNIVKKGYLLKKGKGKRWKNLYFILEGSDAQLIYFESE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_072 NDTVDGKEIYNTIRRKTKDAFYKNIVKKGYLLKKGKGKRWKNLYFILEGSDAQLIYFESE 280 290 300 310 320 330 520 530 540 550 560 570 pF1KE4 KRATKPKGLIDLSVCSVYVVHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_072 KRATKPKGLIDLSVCSVYVVHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMK 340 350 360 370 380 390 580 590 600 610 620 630 pF1KE4 GLQAFCNLRKSSPGTSNKRLRQVSSLVLHIEEAHKLPVKHFTNPYCNIYLNSVQVAKTHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_072 GLQAFCNLRKSSPGTSNKRLRQVSSLVLHIEEAHKLPVKHFTNPYCNIYLNSVQVAKTHA 400 410 420 430 440 450 640 650 660 670 680 690 pF1KE4 REGQNPVWSEEFVFDDLPPDINRFEITLSNKTKKSKDPDILFMRCQLSRLQKGHATDEWF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_072 REGQNPVWSEEFVFDDLPPDINRFEITLSNKTKKSKDPDILFMRCQLSRLQKGHATDEWF 460 470 480 490 500 510 700 710 720 730 740 750 pF1KE4 LLSSHIPLKGIEPGSLRVRARYSMEKIMPEEEYSEFKELILQKELHVVYALSHVCGQDRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_072 LLSSHIPLKGIEPGSLRVRARYSMEKIMPEEEYSEFKELILQKELHVVYALSHVCGQDRT 520 530 540 550 560 570 760 770 780 790 800 810 pF1KE4 LLASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_072 LLASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFV 580 590 600 610 620 630 820 830 840 850 860 870 pF1KE4 HHALKDSILKIMESKQSCELSPSKLEKNEDVNTNLTHLLNILSELVEKIFMASEILPPTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_072 HHALKDSILKIMESKQSCELSPSKLEKNEDVNTNLTHLLNILSELVEKIFMASEILPPTL 640 650 660 670 680 690 880 890 900 910 920 930 pF1KE4 RYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_072 RYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTL 700 710 720 730 740 750 940 950 960 970 980 990 pF1KE4 ILVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTEHSRTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_072 ILVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTEHSRTD 760 770 780 790 800 810 1000 1010 1020 1030 1040 pF1KE4 LSRDLAALHEICVAHSDELRTLSNERGAQQHVLKKLLAITELLQQKQNQYTKTNDVR ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_072 LSRDLAALHEICVAHSDELRTLSNERGAQQHVLKKLLAITELLQQKQNQYTKTNDVR 820 830 840 850 860 870 >>XP_011541829 (OMIM: 139150,605462,608354,608355) PREDI (539 aa) initn: 3608 init1: 3608 opt: 3608 Z-score: 1932.7 bits: 368.3 E(85289): 6.5e-101 Smith-Waterman score: 3608; 100.0% identity (100.0% similar) in 536 aa overlap (1-536:1-536) 10 20 30 40 50 60 pF1KE4 MMAAEAGSEEGGPVTAGAGGGGAAAGSSAYPAVCRVKIPAALPVAAAPYPGLVETGVAGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MMAAEAGSEEGGPVTAGAGGGGAAAGSSAYPAVCRVKIPAALPVAAAPYPGLVETGVAGT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 LGGGAALGSEFLGAGSVAGALGGAGLTGGGTAAGVAGAAAGVAGAAVAGPSGDMALTKLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGGGAALGSEFLGAGSVAGALGGAGLTGGGTAAGVAGAAAGVAGAAVAGPSGDMALTKLP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 TSLLAETLGPGGGFPPLPPPPYLPPLGAGLGTVDEGDSLDGPEYEEEEVAIPLTAPPTNQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TSLLAETLGPGGGFPPLPPPPYLPPLGAGLGTVDEGDSLDGPEYEEEEVAIPLTAPPTNQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 WYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 IGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEPVEDRRRVRAILPYTKVPDTDEIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEPVEDRRRVRAILPYTKVPDTDEIS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 FLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKISKQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKISKQE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 AYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFMMGGRYYNSIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFMMGGRYYNSIG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 DIIDHYRKEQIVEGYYLKEPVPMQDQEQVLNDTVDGKEIYNTIRRKTKDAFYKNIVKKGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DIIDHYRKEQIVEGYYLKEPVPMQDQEQVLNDTVDGKEIYNTIRRKTKDAFYKNIVKKGY 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 LLKKGKGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGRPNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLKKGKGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGSFR 490 500 510 520 530 550 560 570 580 590 600 pF1KE4 FQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKRLRQVSSLVLHI >>XP_016858344 (OMIM: 606136) PREDICTED: ras GTPase-acti (1138 aa) initn: 366 init1: 239 opt: 649 Z-score: 362.8 bits: 78.9 E(85289): 1.8e-13 Smith-Waterman score: 669; 27.9% identity (60.5% similar) in 534 aa overlap (526-1044:115-629) 500 510 520 530 540 550 pF1KE4 ILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGRPNCFQIVVQHFSEEHYIF :: .:.:..:. ::... :. XP_016 PKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKC---- 90 100 110 120 130 140 560 570 580 590 600 610 pF1KE4 YFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKRLRQVSSLVLHIEEAHKL-PVKHFTNP :. .. . . ::..:. : .:. .: : : . : : : ::. : : :.. XP_016 -FSCNSASERDKWMENLR-----RTVQPNKDNCR-RAENVLRLWIIEAKDLAPKKKY--- 150 160 170 180 190 620 630 640 650 660 pF1KE4 YCNIYLNSVQVAKTHAR-EGQNPVWSEEFVFDDLPPDINRFEITL----SNKTKKSKDPD .:.. :... :.: .. ...: :.:.: : .::: .. . . . .: ::.:. XP_016 FCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPP-LHSITVHIYKDVEKKKKKDKNNY 200 210 220 230 240 670 680 690 700 710 720 pF1KE4 ILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPG-SLRVRARYSMEKIMPEEEYSEFKE . .. . . . ...:. .:. : :: : :.:...:.. :.: :.:.:: : XP_016 VGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAE 250 260 270 280 290 300 730 740 750 760 770 780 pF1KE4 LILQKELHVVYALSHVCG-QDRTLLASILLRIFLHEKLESLLLCTLNDREISMEDEATTL .. .. . .: : . ... :: :..:. . .: : :.. : .: XP_016 FVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVL 310 320 330 340 350 360 790 800 810 820 830 840 pF1KE4 -FRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNEDVNTNLT :: .:.:. .:.:.: .. :..: :: . : ..:: ..::..::: ..: .. . . XP_016 IFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQSN 370 380 390 400 410 420 850 860 870 880 890 900 pF1KE4 HLLNILSELVE-KIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRLI :.. ::. ::. . ..: :. ... ... .. . . :..:. .:::.. XP_016 --LKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDIS--ERLISASLFLRFL 430 440 450 460 470 480 910 920 930 940 950 960 pF1KE4 CPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNKH ::::..: .::.... :. ..::: :.:: .:::::...:: :: :: .: :.. . XP_016 CPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWG 490 500 510 520 530 540 970 980 990 1000 1010 1020 pF1KE4 RMIMFLDELGNVPELPDTTEHS-RTDLSRDLAALHEICVAHSDEL-RTLSNERGAQQHVL : :: :..: . .: . ::.:.:..:: . ..: .. . : .:: XP_016 GMKRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKATVAKLGPLPRVL 550 560 570 580 590 600 1030 1040 pF1KE4 K---KLLAITELLQQKQNQYTKTNDVR : :. .::. ..:. : XP_016 ADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNT 610 620 630 640 650 660 >>NP_733793 (OMIM: 606136) ras GTPase-activating protein (1280 aa) initn: 366 init1: 239 opt: 649 Z-score: 362.1 bits: 78.9 E(85289): 2e-13 Smith-Waterman score: 669; 27.9% identity (60.5% similar) in 534 aa overlap (526-1044:260-774) 500 510 520 530 540 550 pF1KE4 ILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGRPNCFQIVVQHFSEEHYIF :: .:.:..:. ::... :. NP_733 PKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKC---- 230 240 250 260 270 280 560 570 580 590 600 610 pF1KE4 YFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKRLRQVSSLVLHIEEAHKL-PVKHFTNP :. .. . . ::..:. : .:. .: : : . : : : ::. : : :.. NP_733 -FSCNSASERDKWMENLR-----RTVQPNKDNCR-RAENVLRLWIIEAKDLAPKKKY--- 290 300 310 320 330 620 630 640 650 660 pF1KE4 YCNIYLNSVQVAKTHAR-EGQNPVWSEEFVFDDLPPDINRFEITL----SNKTKKSKDPD .:.. :... :.: .. ...: :.:.: : .::: .. . . . .: ::.:. NP_733 FCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPP-LHSITVHIYKDVEKKKKKDKNNY 340 350 360 370 380 390 670 680 690 700 710 720 pF1KE4 ILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPG-SLRVRARYSMEKIMPEEEYSEFKE . .. . . . ...:. .:. : :: : :.:...:.. :.: :.:.:: : NP_733 VGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAE 400 410 420 430 440 450 730 740 750 760 770 780 pF1KE4 LILQKELHVVYALSHVCG-QDRTLLASILLRIFLHEKLESLLLCTLNDREISMEDEATTL .. .. . .: : . ... :: :..:. . .: : :.. : .: NP_733 FVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVL 460 470 480 490 500 510 790 800 810 820 830 840 pF1KE4 -FRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNEDVNTNLT :: .:.:. .:.:.: .. :..: :: . : ..:: ..::..::: ..: .. . . NP_733 IFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQSN 520 530 540 550 560 570 850 860 870 880 890 900 pF1KE4 HLLNILSELVE-KIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRLI :.. ::. ::. . ..: :. ... ... .. . . :..:. .:::.. NP_733 --LKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDIS--ERLISASLFLRFL 580 590 600 610 620 630 910 920 930 940 950 960 pF1KE4 CPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNKH ::::..: .::.... :. ..::: :.:: .:::::...:: :: :: .: :.. . NP_733 CPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWG 640 650 660 670 680 690 970 980 990 1000 1010 1020 pF1KE4 RMIMFLDELGNVPELPDTTEHS-RTDLSRDLAALHEICVAHSDEL-RTLSNERGAQQHVL : :: :..: . .: . ::.:.:..:: . ..: .. . : .:: NP_733 GMKRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKATVAKLGPLPRVL 700 710 720 730 740 750 1030 1040 pF1KE4 K---KLLAITELLQQKQNQYTKTNDVR : :. .::. ..:. : NP_733 ADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNT 760 770 780 790 800 810 >>XP_016858341 (OMIM: 606136) PREDICTED: ras GTPase-acti (1409 aa) initn: 366 init1: 239 opt: 649 Z-score: 361.6 bits: 79.0 E(85289): 2.1e-13 Smith-Waterman score: 669; 27.9% identity (60.5% similar) in 534 aa overlap (526-1044:389-903) 500 510 520 530 540 550 pF1KE4 ILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGRPNCFQIVVQHFSEEHYIF :: .:.:..:. ::... :. XP_016 PKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKC---- 360 370 380 390 400 410 560 570 580 590 600 610 pF1KE4 YFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKRLRQVSSLVLHIEEAHKL-PVKHFTNP :. .. . . ::..:. : .:. .: : : . : : : ::. : : :.. XP_016 -FSCNSASERDKWMENLR-----RTVQPNKDNCR-RAENVLRLWIIEAKDLAPKKKY--- 420 430 440 450 460 620 630 640 650 660 pF1KE4 YCNIYLNSVQVAKTHAR-EGQNPVWSEEFVFDDLPPDINRFEITL----SNKTKKSKDPD .:.. :... :.: .. ...: :.:.: : .::: .. . . . .: ::.:. XP_016 FCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPP-LHSITVHIYKDVEKKKKKDKNNY 470 480 490 500 510 520 670 680 690 700 710 720 pF1KE4 ILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPG-SLRVRARYSMEKIMPEEEYSEFKE . .. . . . ...:. .:. : :: : :.:...:.. :.: :.:.:: : XP_016 VGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAE 530 540 550 560 570 580 730 740 750 760 770 780 pF1KE4 LILQKELHVVYALSHVCG-QDRTLLASILLRIFLHEKLESLLLCTLNDREISMEDEATTL .. .. . .: : . ... :: :..:. . .: : :.. : .: XP_016 FVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVL 590 600 610 620 630 640 790 800 810 820 830 840 pF1KE4 -FRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNEDVNTNLT :: .:.:. .:.:.: .. :..: :: . : ..:: ..::..::: ..: .. . . XP_016 IFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQSN 650 660 670 680 690 700 850 860 870 880 890 900 pF1KE4 HLLNILSELVE-KIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRLI :.. ::. ::. . ..: :. ... ... .. . . :..:. .:::.. XP_016 --LKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDIS--ERLISASLFLRFL 710 720 730 740 750 910 920 930 940 950 960 pF1KE4 CPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNKH ::::..: .::.... :. ..::: :.:: .:::::...:: :: :: .: :.. . XP_016 CPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWG 760 770 780 790 800 810 970 980 990 1000 1010 1020 pF1KE4 RMIMFLDELGNVPELPDTTEHS-RTDLSRDLAALHEICVAHSDEL-RTLSNERGAQQHVL : :: :..: . .: . ::.:.:..:: . ..: .. . : .:: XP_016 GMKRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKATVAKLGPLPRVL 820 830 840 850 860 870 1030 1040 pF1KE4 K---KLLAITELLQQKQNQYTKTNDVR : :. .::. ..:. : XP_016 ADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNT 880 890 900 910 920 930 >>XP_016858340 (OMIM: 606136) PREDICTED: ras GTPase-acti (1412 aa) initn: 366 init1: 239 opt: 649 Z-score: 361.6 bits: 79.0 E(85289): 2.1e-13 Smith-Waterman score: 669; 27.9% identity (60.5% similar) in 534 aa overlap (526-1044:389-903) 500 510 520 530 540 550 pF1KE4 ILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGRPNCFQIVVQHFSEEHYIF :: .:.:..:. ::... :. XP_016 PKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKC---- 360 370 380 390 400 410 560 570 580 590 600 610 pF1KE4 YFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKRLRQVSSLVLHIEEAHKL-PVKHFTNP :. .. . . ::..:. : .:. .: : : . : : : ::. : : :.. XP_016 -FSCNSASERDKWMENLR-----RTVQPNKDNCR-RAENVLRLWIIEAKDLAPKKKY--- 420 430 440 450 460 620 630 640 650 660 pF1KE4 YCNIYLNSVQVAKTHAR-EGQNPVWSEEFVFDDLPPDINRFEITL----SNKTKKSKDPD .:.. :... :.: .. ...: :.:.: : .::: .. . . . .: ::.:. XP_016 FCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPP-LHSITVHIYKDVEKKKKKDKNNY 470 480 490 500 510 520 670 680 690 700 710 720 pF1KE4 ILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPG-SLRVRARYSMEKIMPEEEYSEFKE . .. . . . ...:. .:. : :: : :.:...:.. :.: :.:.:: : XP_016 VGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAE 530 540 550 560 570 580 730 740 750 760 770 780 pF1KE4 LILQKELHVVYALSHVCG-QDRTLLASILLRIFLHEKLESLLLCTLNDREISMEDEATTL .. .. . .: : . ... :: :..:. . .: : :.. : .: XP_016 FVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVL 590 600 610 620 630 640 790 800 810 820 830 840 pF1KE4 -FRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNEDVNTNLT :: .:.:. .:.:.: .. :..: :: . : ..:: ..::..::: ..: .. . . XP_016 IFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQSN 650 660 670 680 690 700 850 860 870 880 890 900 pF1KE4 HLLNILSELVE-KIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRLI :.. ::. ::. . ..: :. ... ... .. . . :..:. .:::.. XP_016 --LKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDIS--ERLISASLFLRFL 710 720 730 740 750 910 920 930 940 950 960 pF1KE4 CPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNKH ::::..: .::.... :. ..::: :.:: .:::::...:: :: :: .: :.. . XP_016 CPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWG 760 770 780 790 800 810 970 980 990 1000 1010 1020 pF1KE4 RMIMFLDELGNVPELPDTTEHS-RTDLSRDLAALHEICVAHSDEL-RTLSNERGAQQHVL : :: :..: . .: . ::.:.:..:: . ..: .. . : .:: XP_016 GMKRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKATVAKLGPLPRVL 820 830 840 850 860 870 1030 1040 pF1KE4 K---KLLAITELLQQKQNQYTKTNDVR : :. .::. ..:. : XP_016 ADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNT 880 890 900 910 920 930 >>NP_004832 (OMIM: 606136) ras GTPase-activating protein (1139 aa) initn: 366 init1: 239 opt: 642 Z-score: 359.0 bits: 78.2 E(85289): 2.9e-13 Smith-Waterman score: 665; 27.9% identity (60.3% similar) in 541 aa overlap (526-1044:112-633) 500 510 520 530 540 550 pF1KE4 ILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGRPNCFQIVVQHFSEEHYIF :: .:.:..:. ::... :. NP_004 PKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKC---- 90 100 110 120 130 560 570 580 590 600 610 pF1KE4 YFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKRLRQVSSLVLHIEEAHKL-PVKHFTNP :. .. . . ::..:. : .:. .: : : . : : : ::. : : :.. NP_004 -FSCNSASERDKWMENLR-----RTVQPNKDNCR-RAENVLRLWIIEAKDLAPKKKY--- 140 150 160 170 180 620 630 640 650 660 pF1KE4 YCNIYLNSVQVAKTHAR-EGQNPVWSEEFVFDDLPPDINRFEITL----SNKTKKSKDPD .:.. :... :.: .. ...: :.:.: : .::: .. . . . .: ::.:. NP_004 FCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPP-LHSITVHIYKDVEKKKKKDKNNY 190 200 210 220 230 240 670 680 690 700 710 720 pF1KE4 ILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPG-SLRVRARYSMEKIMPEEEYSEFKE . .. . . . ...:. .:. : :: : :.:...:.. :.: :.:.:: : NP_004 VGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAE 250 260 270 280 290 300 730 740 750 760 770 780 pF1KE4 LILQKELHVVYALSHVCG-QDRTLLASILLRIFLHEKLESLLLCTLNDREISMEDEATTL .. .. . .: : . ... :: :..:. . .: : :.. : .: NP_004 FVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVL 310 320 330 340 350 360 790 800 810 820 830 840 pF1KE4 -FRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNEDVNTNLT :: .:.:. .:.:.: .. :..: :: . : ..:: ..::..::: ..: .. . . NP_004 IFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQSN 370 380 390 400 410 420 850 860 870 880 890 900 pF1KE4 HLLNILSELVE-KIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRLI :.. ::. ::. . ..: :. ... ... .. . . :..:. .:::.. NP_004 --LKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDIS--ERLISASLFLRFL 430 440 450 460 470 480 910 920 930 940 950 960 pF1KE4 CPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNKH ::::..: .::.... :. ..::: :.:: .:::::...:: :: :: .: :.. . NP_004 CPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWG 490 500 510 520 530 540 970 980 990 1000 1010 pF1KE4 RMIMFLDELGNVPELPDTTEHS-RTDLSRDLAALHEI---CVAHSDE-----LRTLSNER : :: :..: . .: . ::.:.:..:: . :.. :. :.. . NP_004 GMKRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKGENSFLQATVAKL 550 560 570 580 590 600 1020 1030 1040 pF1KE4 GAQQHVLK---KLLAITELLQQKQNQYTKTNDVR : .:: : :. .::. ..:. : NP_004 GPLPRVLADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLK 610 620 630 640 650 660 NP_004 SPSQDNTDSYFRGKTLLLVQQASSQSMTYSEKDERESSLPNGRSVSLMDLQDTHAAQVEH 670 680 690 700 710 720 >>XP_005245679 (OMIM: 606136) PREDICTED: ras GTPase-acti (1142 aa) initn: 366 init1: 239 opt: 642 Z-score: 359.0 bits: 78.2 E(85289): 2.9e-13 Smith-Waterman score: 665; 27.9% identity (60.3% similar) in 541 aa overlap (526-1044:112-633) 500 510 520 530 540 550 pF1KE4 ILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGRPNCFQIVVQHFSEEHYIF :: .:.:..:. ::... :. XP_005 PKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKC---- 90 100 110 120 130 560 570 580 590 600 610 pF1KE4 YFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKRLRQVSSLVLHIEEAHKL-PVKHFTNP :. .. . . ::..:. : .:. .: : : . : : : ::. : : :.. XP_005 -FSCNSASERDKWMENLR-----RTVQPNKDNCR-RAENVLRLWIIEAKDLAPKKKY--- 140 150 160 170 180 620 630 640 650 660 pF1KE4 YCNIYLNSVQVAKTHAR-EGQNPVWSEEFVFDDLPPDINRFEITL----SNKTKKSKDPD .:.. :... :.: .. ...: :.:.: : .::: .. . . . .: ::.:. XP_005 FCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPP-LHSITVHIYKDVEKKKKKDKNNY 190 200 210 220 230 240 670 680 690 700 710 720 pF1KE4 ILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPG-SLRVRARYSMEKIMPEEEYSEFKE . .. . . . ...:. .:. : :: : :.:...:.. :.: :.:.:: : XP_005 VGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAE 250 260 270 280 290 300 730 740 750 760 770 780 pF1KE4 LILQKELHVVYALSHVCG-QDRTLLASILLRIFLHEKLESLLLCTLNDREISMEDEATTL .. .. . .: : . ... :: :..:. . .: : :.. : .: XP_005 FVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVL 310 320 330 340 350 360 790 800 810 820 830 840 pF1KE4 -FRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNEDVNTNLT :: .:.:. .:.:.: .. :..: :: . : ..:: ..::..::: ..: .. . . XP_005 IFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQSN 370 380 390 400 410 420 850 860 870 880 890 900 pF1KE4 HLLNILSELVE-KIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRLI :.. ::. ::. . ..: :. ... ... .. . . :..:. .:::.. XP_005 --LKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDIS--ERLISASLFLRFL 430 440 450 460 470 480 910 920 930 940 950 960 pF1KE4 CPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNKH ::::..: .::.... :. ..::: :.:: .:::::...:: :: :: .: :.. . XP_005 CPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWG 490 500 510 520 530 540 970 980 990 1000 1010 pF1KE4 RMIMFLDELGNVPELPDTTEHS-RTDLSRDLAALHEI---CVAHSDE-----LRTLSNER : :: :..: . .: . ::.:.:..:: . :.. :. :.. . XP_005 GMKRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKGENSFLQATVAKL 550 560 570 580 590 600 1020 1030 1040 pF1KE4 GAQQHVLK---KLLAITELLQQKQNQYTKTNDVR : .:: : :. .::. ..:. : XP_005 GPLPRVLADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLK 610 620 630 640 650 660 XP_005 SPSQDNTDSYFRGKTLLLVQQASSQSMTYSEKDERESSLPNGRSVSLMDLQDTHAAQVEH 670 680 690 700 710 720 1047 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 06:56:53 2016 done: Tue Nov 8 06:56:54 2016 Total Scan time: 12.410 Total Display time: 0.220 Function used was FASTA [36.3.4 Apr, 2011]