FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2314, 2048 aa 1>>>pF1KE2314 2048 - 2048 aa - 2048 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.2541+/-0.000529; mu= 15.7042+/- 0.033 mean_var=126.3708+/-25.064, 0's: 0 Z-trim(110.4): 128 B-trim: 0 in 0/57 Lambda= 0.114091 statistics sampled from 18576 (18694) to 18576 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.553), E-opt: 0.2 (0.219), width: 16 Scan time: 18.840 The best scores are: opt bits E(85289) NP_065988 (OMIM: 189960,609644,614087) Fanconi ane (2048) 13460 2228.8 0 XP_011535336 (OMIM: 189960,609644,614087) PREDICTE (2053) 13440 2225.5 0 NP_001295062 (OMIM: 189960,609644,614087) Fanconi (2022) 11746 1946.7 0 XP_016877012 (OMIM: 189960,609644,614087) PREDICTE (1801) 11726 1943.4 0 XP_011535337 (OMIM: 189960,609644,614087) PREDICTE (2027) 11726 1943.4 0 XP_016877013 (OMIM: 189960,609644,614087) PREDICTE (1732) 11314 1875.6 0 XP_016877016 (OMIM: 189960,609644,614087) PREDICTE (1653) 10829 1795.7 0 XP_016877014 (OMIM: 189960,609644,614087) PREDICTE (1658) 10809 1792.4 0 XP_016877015 (OMIM: 189960,609644,614087) PREDICTE (1658) 10809 1792.4 0 XP_011535339 (OMIM: 189960,609644,614087) PREDICTE (1391) 9024 1498.6 0 NP_001295063 (OMIM: 189960,609644,614087) Fanconi ( 669) 4425 741.4 7.6e-213 NP_055129 (OMIM: 609631,616298) probable ATP-depen ( 925) 363 72.9 1.9e-11 XP_016880548 (OMIM: 608588) PREDICTED: probable AT ( 678) 247 53.7 8e-06 XP_016880549 (OMIM: 608588) PREDICTED: probable AT ( 678) 247 53.7 8e-06 NP_077024 (OMIM: 608588) probable ATP-dependent RN ( 678) 247 53.7 8e-06 NP_071451 (OMIM: 182250,606951,615846) interferon- (1025) 227 50.5 0.00011 NP_060365 (OMIM: 616621) probable ATP-dependent RN ( 796) 191 44.5 0.0054 XP_011527190 (OMIM: 616621) PREDICTED: probable AT ( 827) 191 44.5 0.0056 >>NP_065988 (OMIM: 189960,609644,614087) Fanconi anemia (2048 aa) initn: 13460 init1: 13460 opt: 13460 Z-score: 11972.2 bits: 2228.8 E(85289): 0 Smith-Waterman score: 13460; 99.9% identity (100.0% similar) in 2048 aa overlap (1-2048:1-2048) 10 20 30 40 50 60 pF1KE2 MSGRQRTLFQTWGSSISRSSGTPGCSSGTERPQSPGSSKAPLPAAAEAQLESDDDVLLVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 MSGRQRTLFQTWGSSISRSSGTPGCSSGTERPQSPGSSKAPLPAAAEAQLESDDDVLLVA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 AYEAERQLCLENGGFCTSAGALWIYPTNCPVRDYQLHISRAALFCNTLVCLPTGLGKTFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 AYEAERQLCLENGGFCTSAGALWIYPTNCPVRDYQLHISRAALFCNTLVCLPTGLGKTFI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 AAVVMYNFYRWFPSGKVVFMAPTKPLVTQQIEACYQVMGIPQSHMAEMTGSTQASTRKEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 AAVVMYNFYRWFPSGKVVFMAPTKPLVTQQIEACYQVMGIPQSHMAEMTGSTQASTRKEI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 WCSKRVLFLTPQVMVNDLSRGACPAAEIKCLVIDEAHKALGNYAYCQVVRELVKYTNHFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 WCSKRVLFLTPQVMVNDLSRGACPAAEIKCLVIDEAHKALGNYAYCQVVRELVKYTNHFR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 ILALSATPGSDIKAVQQVITNLLIGQIELRSEDSPDILTYSHERKVEKLIVPLGEELAAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 ILALSATPGSDIKAVQQVITNLLIGQIELRSEDSPDILTYSHERKVEKLIVPLGEELAAI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 QKTYIQILESFARSLIQRNVLMRRDIPNLTKYQIILARDQFRKNPSPNIVGIQQGIIEGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 QKTYIQILESFARSLIQRNVLMRRDIPNLTKYQIILARDQFRKNPSPNIVGIQQGIIEGE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 FAICISLYHGYELLQQMGMRSLYFFLCGIMDGTKGMTRSKNELGRNEDFMKLYNHLECMF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 FAICISLYHGYELLQQMGMRSLYFFLCGIMDGTKGMTRSKNELGRNEDFMKLYNHLECMF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 ARTRSTSANGISAIQQGDKNKKFVYSHPKLKKLEEVVIEHFKSWNAENTTEKKRDETRVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 ARTRSTSANGISAIQQGDKNKKFVYSHPKLKKLEEVVIEHFKSWNAENTTEKKRDETRVM 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 IFSSFRDSVQEIAEMLSQHQPIIRVMTFVGHASGKSTKGFTQKEQLEVVKQFRDGGYNTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 IFSSFRDSVQEIAEMLSQHQPIIRVMTFVGHASGKSTKGFTQKEQLEVVKQFRDGGYNTL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 VSTCVGEEGLDIGEVDLIICFDSQKSPIRLVQRMGRTGRKRQGRIVIILSEGREERIYNQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 VSTCVGEEGLDIGEVDLIICFDSQKSPIRLVQRMGRTGRKRQGRIVIILSEGREERIYNQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 SQSNKRSIYKAISSNRQVLHFYQRSPRMVPDGINPKLHKMFITHGVYEPEKPSRNLQRKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 SQSNKRSIYKAISSNRQVLHFYQRSPRMVPDGINPKLHKMFITHGVYEPEKPSRNLQRKS 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 SIFSYRDGMRQSSLKKDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQVQFSSLQNEENKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 SIFSYRDGMRQSSLKKDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQVQFSSLQNEENKP 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 AQESTTGIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIEGMRHEEGECSYELE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 AQESTTGIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIEGMRHEEGECSYELE 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 VESYLQMEDVTSTFIAPRNESNNLASDTFITHKKSSFIKNINQGSSSSVIESDEECAEIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 VESYLQMEDVTSTFIAPRNESNNLASDTFITHKKSSFIKNINQGSSSSVIESDEECAEIV 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE2 KQTHIKPTKIVSLKKKVSKEIKKDQLKKENNHGIIDSLDNDRNSTVENIFQEDLPNDKRT :::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::: NP_065 KQTHIKPTKIVSLKKKVSKEIKKDQLKKENNHGIIDSVDNDRNSTVENIFQEDLPNDKRT 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE2 SDTDEIAATCTINENVIKEPCVLLTECQFTNKSTSSLAGNVLDSGYNSFNDEKSVSSNLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 SDTDEIAATCTINENVIKEPCVLLTECQFTNKSTSSLAGNVLDSGYNSFNDEKSVSSNLF 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE2 LPFEEELYIVRTDDQFYNCHSLTKEVLANVERFLSYSPPPLSGLSDLEYEIAKGTALENL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 LPFEEELYIVRTDDQFYNCHSLTKEVLANVERFLSYSPPPLSGLSDLEYEIAKGTALENL 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE2 LFLPCAEHLRSDKCTCLLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPNDNISDEPSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 LFLPCAEHLRSDKCTCLLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPNDNISDEPSL 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE2 CDCDVHKHNQNENLVPNNRVQIHRSPAQNLVGENNHDVDNSDLPVLSTDQDESLLLFEDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 CDCDVHKHNQNENLVPNNRVQIHRSPAQNLVGENNHDVDNSDLPVLSTDQDESLLLFEDV 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE2 NTEFDDVSLSPLNSKSESLPVSDKTAISETPLVSQFLISDELLLDNNSELQDQITRDANS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 NTEFDDVSLSPLNSKSESLPVSDKTAISETPLVSQFLISDELLLDNNSELQDQITRDANS 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KE2 FKSRDQRGVQEEKVKNHEDIFDCSRDLFSVTFDLGFCSPDSDDEILEHTSDSNRPLDDLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 FKSRDQRGVQEEKVKNHEDIFDCSRDLFSVTFDLGFCSPDSDDEILEHTSDSNRPLDDLY 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KE2 GRYLEIKEISDANYVSNQALIPRDHSKNFTSGTVIIPSNEDMQNPNYVHLPLSAAKNEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 GRYLEIKEISDANYVSNQALIPRDHSKNFTSGTVIIPSNEDMQNPNYVHLPLSAAKNEEL 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KE2 LSPGYSQFSLPVQKKVMSTPLSKSNTLNSFSKIRKEILKTPDSSKEKVNLQRFKEALNST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 LSPGYSQFSLPVQKKVMSTPLSKSNTLNSFSKIRKEILKTPDSSKEKVNLQRFKEALNST 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KE2 FDYSEFSLEKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEIFRRKVKRAKGNVLNSPED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 FDYSEFSLEKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEIFRRKVKRAKGNVLNSPED 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 1500 pF1KE2 QKNSEVDSPLHAVKKRRFPVNRSELSSSDESENFPKPCSQLEDFKVCNGNARRGIKVPKR :::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::: NP_065 QKNSEVDSPLHAVKKRRFPINRSELSSSDESENFPKPCSQLEDFKVCNGNARRGIKVPKR 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 pF1KE2 QSHLKHVARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDFLNDETQLSQAINDSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 QSHLKHVARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDFLNDETQLSQAINDSE 1510 1520 1530 1540 1550 1560 1570 1580 1590 1600 1610 1620 pF1KE2 MRAIYMKSLRSPMMNNKYKMIHKTHKNINIFSQIPEQDETYLEDSFCVDEEESCKGQSSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 MRAIYMKSLRSPMMNNKYKMIHKTHKNINIFSQIPEQDETYLEDSFCVDEEESCKGQSSE 1570 1580 1590 1600 1610 1620 1630 1640 1650 1660 1670 1680 pF1KE2 EEVCVDFNLITDDCFANSKKYKTRRAVMLKEMMEQNCAHSKKKLSRIILPDDSSEEENNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 EEVCVDFNLITDDCFANSKKYKTRRAVMLKEMMEQNCAHSKKKLSRIILPDDSSEEENNV 1630 1640 1650 1660 1670 1680 1690 1700 1710 1720 1730 1740 pF1KE2 NDKRESNIAVNPSTVKKNKQQDHCLNSVPSGSSAQSKVRSTPRVNPLAKQSKQTSLNLKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 NDKRESNIAVNPSTVKKNKQQDHCLNSVPSGSSAQSKVRSTPRVNPLAKQSKQTSLNLKD 1690 1700 1710 1720 1730 1740 1750 1760 1770 1780 1790 1800 pF1KE2 TISEVSDFKPQNHNEVQSTTPPFTTVDSQKDCRKFPVPQKDGSALEDSSTSGASCSKSRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 TISEVSDFKPQNHNEVQSTTPPFTTVDSQKDCRKFPVPQKDGSALEDSSTSGASCSKSRP 1750 1760 1770 1780 1790 1800 1810 1820 1830 1840 1850 1860 pF1KE2 HLAGTHTSLRLAQEGKGTCILVGGHEITSGLEVISSLRAIHGLQVEVCPLNGCDYIVSNR ::::::::::: :::::::::::::::::::::::::::::::::::::::::::::::: NP_065 HLAGTHTSLRLPQEGKGTCILVGGHEITSGLEVISSLRAIHGLQVEVCPLNGCDYIVSNR 1810 1820 1830 1840 1850 1860 1870 1880 1890 1900 1910 1920 pF1KE2 MVVERRSQSEMLNSVNKNKFIEQIQHLQSMFERICVIVEKDREKTGDTSRMFRRTKSYDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 MVVERRSQSEMLNSVNKNKFIEQIQHLQSMFERICVIVEKDREKTGDTSRMFRRTKSYDS 1870 1880 1890 1900 1910 1920 1930 1940 1950 1960 1970 1980 pF1KE2 LLTTLIGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVNSNKSEALQFYLSIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 LLTTLIGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVNSNKSEALQFYLSIP 1930 1940 1950 1960 1970 1980 1990 2000 2010 2020 2030 2040 pF1KE2 NISYITALNMCHQFSSVKRMANSSLQEISMYAQVTHQKAEEIYRYIHYVFDIQMLPNDLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 NISYITALNMCHQFSSVKRMANSSLQEISMYAQVTHQKAEEIYRYIHYVFDIQMLPNDLN 1990 2000 2010 2020 2030 2040 pF1KE2 QDRLKSDI :::::::: NP_065 QDRLKSDI >>XP_011535336 (OMIM: 189960,609644,614087) PREDICTED: F (2053 aa) initn: 9647 init1: 9647 opt: 13440 Z-score: 11954.4 bits: 2225.5 E(85289): 0 Smith-Waterman score: 13440; 99.6% identity (99.7% similar) in 2053 aa overlap (1-2048:1-2053) 10 20 30 40 50 60 pF1KE2 MSGRQRTLFQTWGSSISRSSGTPGCSSGTERPQSPGSSKAPLPAAAEAQLESDDDVLLVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSGRQRTLFQTWGSSISRSSGTPGCSSGTERPQSPGSSKAPLPAAAEAQLESDDDVLLVA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 AYEAERQLCLENGGFCTSAGALWIYPTNCPVRDYQLHISRAALFCNTLVCLPTGLGKTFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AYEAERQLCLENGGFCTSAGALWIYPTNCPVRDYQLHISRAALFCNTLVCLPTGLGKTFI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 AAVVMYNFYRWFPSGKVVFMAPTKPLVTQQIEACYQVMGIPQSHMAEMTGSTQASTRKEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AAVVMYNFYRWFPSGKVVFMAPTKPLVTQQIEACYQVMGIPQSHMAEMTGSTQASTRKEI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 WCSKRVLFLTPQVMVNDLSRGACPAAEIKCLVIDEAHKALGNYAYCQVVRELVKYTNHFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WCSKRVLFLTPQVMVNDLSRGACPAAEIKCLVIDEAHKALGNYAYCQVVRELVKYTNHFR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 ILALSATPGSDIKAVQQVITNLLIGQIELRSEDSPDILTYSHERKVEKLIVPLGEELAAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ILALSATPGSDIKAVQQVITNLLIGQIELRSEDSPDILTYSHERKVEKLIVPLGEELAAI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 QKTYIQILESFARSLIQRNVLMRRDIPNLTKYQIILARDQFRKNPSPNIVGIQQGIIEGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QKTYIQILESFARSLIQRNVLMRRDIPNLTKYQIILARDQFRKNPSPNIVGIQQGIIEGE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 FAICISLYHGYELLQQMGMRSLYFFLCGIMDGTKGMTRSKNELGRNEDFMKLYNHLECMF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FAICISLYHGYELLQQMGMRSLYFFLCGIMDGTKGMTRSKNELGRNEDFMKLYNHLECMF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 ARTRSTSANGISAIQQGDKNKKFVYSHPKLKKLEEVVIEHFKSWNAENTTEKKRDETRVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ARTRSTSANGISAIQQGDKNKKFVYSHPKLKKLEEVVIEHFKSWNAENTTEKKRDETRVM 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 IFSSFRDSVQEIAEMLSQHQPIIRVMTFVGHASGKSTKGFTQKEQLEVVKQFRDGGYNTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IFSSFRDSVQEIAEMLSQHQPIIRVMTFVGHASGKSTKGFTQKEQLEVVKQFRDGGYNTL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 VSTCVGEEGLDIGEVDLIICFDSQKSPIRLVQRMGRTGRKRQGRIVIILSEGREERIYNQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VSTCVGEEGLDIGEVDLIICFDSQKSPIRLVQRMGRTGRKRQGRIVIILSEGREERIYNQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 SQSNKRSIYKAISSNRQVLHFYQRSPRMVPDGINPKLHKMFITHGVYEPEKPSRNLQRKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SQSNKRSIYKAISSNRQVLHFYQRSPRMVPDGINPKLHKMFITHGVYEPEKPSRNLQRKS 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 SIFSYRDGMRQSSLKKDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQVQFSSLQNEENKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SIFSYRDGMRQSSLKKDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQVQFSSLQNEENKP 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 AQESTTGIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIEGMRHEEGECSYELE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AQESTTGIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIEGMRHEEGECSYELE 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 VESYLQMEDVTSTFIAPRNESNNLASDTFITHKKSSFIKNINQGSSSSVIESDEECAEIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VESYLQMEDVTSTFIAPRNESNNLASDTFITHKKSSFIKNINQGSSSSVIESDEECAEIV 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE2 KQTHIKPTKIVSLKKKVSKEIKKDQLKKENNHGIIDSLDNDRNSTVENIFQEDLPNDKRT :::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::: XP_011 KQTHIKPTKIVSLKKKVSKEIKKDQLKKENNHGIIDSVDNDRNSTVENIFQEDLPNDKRT 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE2 SDTDEIAATCTINENVIKEPCVLLTECQFTNKSTSSLAGNVLDSGYNSFNDEKSVSSNLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SDTDEIAATCTINENVIKEPCVLLTECQFTNKSTSSLAGNVLDSGYNSFNDEKSVSSNLF 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE2 LPFEEELYIVRTDDQFYNCHSLTKEVLANVERFLSYSPPPLSGLSDLEYEIAKGTALENL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LPFEEELYIVRTDDQFYNCHSLTKEVLANVERFLSYSPPPLSGLSDLEYEIAKGTALENL 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE2 LFLPCAEHLRSDKCTCLLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPNDNISDEPSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LFLPCAEHLRSDKCTCLLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPNDNISDEPSL 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE2 CDCDVHKHNQNENLVPNNRVQIHRSPAQNLVGENNHDVDNSDLPVLSTDQDESLLLFEDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CDCDVHKHNQNENLVPNNRVQIHRSPAQNLVGENNHDVDNSDLPVLSTDQDESLLLFEDV 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE2 NTEFDDVSLSPLNSKSESLPVSDKTAISETPLVSQFLISDELLLDNNSELQDQITRDANS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NTEFDDVSLSPLNSKSESLPVSDKTAISETPLVSQFLISDELLLDNNSELQDQITRDANS 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KE2 FKSRDQRGVQEEKVKNHEDIFDCSRDLFSVTFDLGFCSPDSDDEILEHTSDSNRPLDDLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FKSRDQRGVQEEKVKNHEDIFDCSRDLFSVTFDLGFCSPDSDDEILEHTSDSNRPLDDLY 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KE2 GRYLEIKEISDANYVSNQALIPRDHSKNFTSGTVIIPSNEDMQNPNYVHLPLSAAKNEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GRYLEIKEISDANYVSNQALIPRDHSKNFTSGTVIIPSNEDMQNPNYVHLPLSAAKNEEL 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KE2 LSPGYSQFSLPVQKKVMSTPLSKSNTLNSFSKIRKEILKTPDSSKEKVNLQRFKEALNST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSPGYSQFSLPVQKKVMSTPLSKSNTLNSFSKIRKEILKTPDSSKEKVNLQRFKEALNST 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KE2 FDYSEFSLEKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEIFRRKVKRAKGNVLNSPED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FDYSEFSLEKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEIFRRKVKRAKGNVLNSPED 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 pF1KE2 QKNSEVDSPLHAVKKRRFPVNR-----SELSSSDESENFPKPCSQLEDFKVCNGNARRGI :::::::::::::::::::.:: ::::::::::::::::::::::::::::::::: XP_011 QKNSEVDSPLHAVKKRRFPINRVSKYQSELSSSDESENFPKPCSQLEDFKVCNGNARRGI 1450 1460 1470 1480 1490 1500 1500 1510 1520 1530 1540 1550 pF1KE2 KVPKRQSHLKHVARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDFLNDETQLSQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KVPKRQSHLKHVARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDFLNDETQLSQA 1510 1520 1530 1540 1550 1560 1560 1570 1580 1590 1600 1610 pF1KE2 INDSEMRAIYMKSLRSPMMNNKYKMIHKTHKNINIFSQIPEQDETYLEDSFCVDEEESCK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 INDSEMRAIYMKSLRSPMMNNKYKMIHKTHKNINIFSQIPEQDETYLEDSFCVDEEESCK 1570 1580 1590 1600 1610 1620 1620 1630 1640 1650 1660 1670 pF1KE2 GQSSEEEVCVDFNLITDDCFANSKKYKTRRAVMLKEMMEQNCAHSKKKLSRIILPDDSSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GQSSEEEVCVDFNLITDDCFANSKKYKTRRAVMLKEMMEQNCAHSKKKLSRIILPDDSSE 1630 1640 1650 1660 1670 1680 1680 1690 1700 1710 1720 1730 pF1KE2 EENNVNDKRESNIAVNPSTVKKNKQQDHCLNSVPSGSSAQSKVRSTPRVNPLAKQSKQTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EENNVNDKRESNIAVNPSTVKKNKQQDHCLNSVPSGSSAQSKVRSTPRVNPLAKQSKQTS 1690 1700 1710 1720 1730 1740 1740 1750 1760 1770 1780 1790 pF1KE2 LNLKDTISEVSDFKPQNHNEVQSTTPPFTTVDSQKDCRKFPVPQKDGSALEDSSTSGASC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LNLKDTISEVSDFKPQNHNEVQSTTPPFTTVDSQKDCRKFPVPQKDGSALEDSSTSGASC 1750 1760 1770 1780 1790 1800 1800 1810 1820 1830 1840 1850 pF1KE2 SKSRPHLAGTHTSLRLAQEGKGTCILVGGHEITSGLEVISSLRAIHGLQVEVCPLNGCDY :::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::: XP_011 SKSRPHLAGTHTSLRLPQEGKGTCILVGGHEITSGLEVISSLRAIHGLQVEVCPLNGCDY 1810 1820 1830 1840 1850 1860 1860 1870 1880 1890 1900 1910 pF1KE2 IVSNRMVVERRSQSEMLNSVNKNKFIEQIQHLQSMFERICVIVEKDREKTGDTSRMFRRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IVSNRMVVERRSQSEMLNSVNKNKFIEQIQHLQSMFERICVIVEKDREKTGDTSRMFRRT 1870 1880 1890 1900 1910 1920 1920 1930 1940 1950 1960 1970 pF1KE2 KSYDSLLTTLIGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVNSNKSEALQF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KSYDSLLTTLIGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVNSNKSEALQF 1930 1940 1950 1960 1970 1980 1980 1990 2000 2010 2020 2030 pF1KE2 YLSIPNISYITALNMCHQFSSVKRMANSSLQEISMYAQVTHQKAEEIYRYIHYVFDIQML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YLSIPNISYITALNMCHQFSSVKRMANSSLQEISMYAQVTHQKAEEIYRYIHYVFDIQML 1990 2000 2010 2020 2030 2040 2040 pF1KE2 PNDLNQDRLKSDI ::::::::::::: XP_011 PNDLNQDRLKSDI 2050 >>NP_001295062 (OMIM: 189960,609644,614087) Fanconi anem (2022 aa) initn: 11746 init1: 11746 opt: 11746 Z-score: 10447.5 bits: 1946.7 E(85289): 0 Smith-Waterman score: 13237; 98.6% identity (98.7% similar) in 2048 aa overlap (1-2048:1-2022) 10 20 30 40 50 60 pF1KE2 MSGRQRTLFQTWGSSISRSSGTPGCSSGTERPQSPGSSKAPLPAAAEAQLESDDDVLLVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSGRQRTLFQTWGSSISRSSGTPGCSSGTERPQSPGSSKAPLPAAAEAQLESDDDVLLVA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 AYEAERQLCLENGGFCTSAGALWIYPTNCPVRDYQLHISRAALFCNTLVCLPTGLGKTFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AYEAERQLCLENGGFCTSAGALWIYPTNCPVRDYQLHISRAALFCNTLVCLPTGLGKTFI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 AAVVMYNFYRWFPSGKVVFMAPTKPLVTQQIEACYQVMGIPQSHMAEMTGSTQASTRKEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AAVVMYNFYRWFPSGKVVFMAPTKPLVTQQIEACYQVMGIPQSHMAEMTGSTQASTRKEI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 WCSKRVLFLTPQVMVNDLSRGACPAAEIKCLVIDEAHKALGNYAYCQVVRELVKYTNHFR ::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WCSKRVLFLTPQVMVNDLSRGACPAAEIKCLVIDEAHKALGNYAYCQ------------- 190 200 210 220 250 260 270 280 290 300 pF1KE2 ILALSATPGSDIKAVQQVITNLLIGQIELRSEDSPDILTYSHERKVEKLIVPLGEELAAI ::::::::::::::::::::::::::::::::::::::::::::::: NP_001 -------------AVQQVITNLLIGQIELRSEDSPDILTYSHERKVEKLIVPLGEELAAI 230 240 250 260 270 310 320 330 340 350 360 pF1KE2 QKTYIQILESFARSLIQRNVLMRRDIPNLTKYQIILARDQFRKNPSPNIVGIQQGIIEGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QKTYIQILESFARSLIQRNVLMRRDIPNLTKYQIILARDQFRKNPSPNIVGIQQGIIEGE 280 290 300 310 320 330 370 380 390 400 410 420 pF1KE2 FAICISLYHGYELLQQMGMRSLYFFLCGIMDGTKGMTRSKNELGRNEDFMKLYNHLECMF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FAICISLYHGYELLQQMGMRSLYFFLCGIMDGTKGMTRSKNELGRNEDFMKLYNHLECMF 340 350 360 370 380 390 430 440 450 460 470 480 pF1KE2 ARTRSTSANGISAIQQGDKNKKFVYSHPKLKKLEEVVIEHFKSWNAENTTEKKRDETRVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ARTRSTSANGISAIQQGDKNKKFVYSHPKLKKLEEVVIEHFKSWNAENTTEKKRDETRVM 400 410 420 430 440 450 490 500 510 520 530 540 pF1KE2 IFSSFRDSVQEIAEMLSQHQPIIRVMTFVGHASGKSTKGFTQKEQLEVVKQFRDGGYNTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IFSSFRDSVQEIAEMLSQHQPIIRVMTFVGHASGKSTKGFTQKEQLEVVKQFRDGGYNTL 460 470 480 490 500 510 550 560 570 580 590 600 pF1KE2 VSTCVGEEGLDIGEVDLIICFDSQKSPIRLVQRMGRTGRKRQGRIVIILSEGREERIYNQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSTCVGEEGLDIGEVDLIICFDSQKSPIRLVQRMGRTGRKRQGRIVIILSEGREERIYNQ 520 530 540 550 560 570 610 620 630 640 650 660 pF1KE2 SQSNKRSIYKAISSNRQVLHFYQRSPRMVPDGINPKLHKMFITHGVYEPEKPSRNLQRKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SQSNKRSIYKAISSNRQVLHFYQRSPRMVPDGINPKLHKMFITHGVYEPEKPSRNLQRKS 580 590 600 610 620 630 670 680 690 700 710 720 pF1KE2 SIFSYRDGMRQSSLKKDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQVQFSSLQNEENKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SIFSYRDGMRQSSLKKDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQVQFSSLQNEENKP 640 650 660 670 680 690 730 740 750 760 770 780 pF1KE2 AQESTTGIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIEGMRHEEGECSYELE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AQESTTGIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIEGMRHEEGECSYELE 700 710 720 730 740 750 790 800 810 820 830 840 pF1KE2 VESYLQMEDVTSTFIAPRNESNNLASDTFITHKKSSFIKNINQGSSSSVIESDEECAEIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VESYLQMEDVTSTFIAPRNESNNLASDTFITHKKSSFIKNINQGSSSSVIESDEECAEIV 760 770 780 790 800 810 850 860 870 880 890 900 pF1KE2 KQTHIKPTKIVSLKKKVSKEIKKDQLKKENNHGIIDSLDNDRNSTVENIFQEDLPNDKRT :::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::: NP_001 KQTHIKPTKIVSLKKKVSKEIKKDQLKKENNHGIIDSVDNDRNSTVENIFQEDLPNDKRT 820 830 840 850 860 870 910 920 930 940 950 960 pF1KE2 SDTDEIAATCTINENVIKEPCVLLTECQFTNKSTSSLAGNVLDSGYNSFNDEKSVSSNLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SDTDEIAATCTINENVIKEPCVLLTECQFTNKSTSSLAGNVLDSGYNSFNDEKSVSSNLF 880 890 900 910 920 930 970 980 990 1000 1010 1020 pF1KE2 LPFEEELYIVRTDDQFYNCHSLTKEVLANVERFLSYSPPPLSGLSDLEYEIAKGTALENL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPFEEELYIVRTDDQFYNCHSLTKEVLANVERFLSYSPPPLSGLSDLEYEIAKGTALENL 940 950 960 970 980 990 1030 1040 1050 1060 1070 1080 pF1KE2 LFLPCAEHLRSDKCTCLLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPNDNISDEPSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LFLPCAEHLRSDKCTCLLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPNDNISDEPSL 1000 1010 1020 1030 1040 1050 1090 1100 1110 1120 1130 1140 pF1KE2 CDCDVHKHNQNENLVPNNRVQIHRSPAQNLVGENNHDVDNSDLPVLSTDQDESLLLFEDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CDCDVHKHNQNENLVPNNRVQIHRSPAQNLVGENNHDVDNSDLPVLSTDQDESLLLFEDV 1060 1070 1080 1090 1100 1110 1150 1160 1170 1180 1190 1200 pF1KE2 NTEFDDVSLSPLNSKSESLPVSDKTAISETPLVSQFLISDELLLDNNSELQDQITRDANS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NTEFDDVSLSPLNSKSESLPVSDKTAISETPLVSQFLISDELLLDNNSELQDQITRDANS 1120 1130 1140 1150 1160 1170 1210 1220 1230 1240 1250 1260 pF1KE2 FKSRDQRGVQEEKVKNHEDIFDCSRDLFSVTFDLGFCSPDSDDEILEHTSDSNRPLDDLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FKSRDQRGVQEEKVKNHEDIFDCSRDLFSVTFDLGFCSPDSDDEILEHTSDSNRPLDDLY 1180 1190 1200 1210 1220 1230 1270 1280 1290 1300 1310 1320 pF1KE2 GRYLEIKEISDANYVSNQALIPRDHSKNFTSGTVIIPSNEDMQNPNYVHLPLSAAKNEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GRYLEIKEISDANYVSNQALIPRDHSKNFTSGTVIIPSNEDMQNPNYVHLPLSAAKNEEL 1240 1250 1260 1270 1280 1290 1330 1340 1350 1360 1370 1380 pF1KE2 LSPGYSQFSLPVQKKVMSTPLSKSNTLNSFSKIRKEILKTPDSSKEKVNLQRFKEALNST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSPGYSQFSLPVQKKVMSTPLSKSNTLNSFSKIRKEILKTPDSSKEKVNLQRFKEALNST 1300 1310 1320 1330 1340 1350 1390 1400 1410 1420 1430 1440 pF1KE2 FDYSEFSLEKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEIFRRKVKRAKGNVLNSPED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FDYSEFSLEKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEIFRRKVKRAKGNVLNSPED 1360 1370 1380 1390 1400 1410 1450 1460 1470 1480 1490 1500 pF1KE2 QKNSEVDSPLHAVKKRRFPVNRSELSSSDESENFPKPCSQLEDFKVCNGNARRGIKVPKR :::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::: NP_001 QKNSEVDSPLHAVKKRRFPINRSELSSSDESENFPKPCSQLEDFKVCNGNARRGIKVPKR 1420 1430 1440 1450 1460 1470 1510 1520 1530 1540 1550 1560 pF1KE2 QSHLKHVARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDFLNDETQLSQAINDSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QSHLKHVARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDFLNDETQLSQAINDSE 1480 1490 1500 1510 1520 1530 1570 1580 1590 1600 1610 1620 pF1KE2 MRAIYMKSLRSPMMNNKYKMIHKTHKNINIFSQIPEQDETYLEDSFCVDEEESCKGQSSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MRAIYMKSLRSPMMNNKYKMIHKTHKNINIFSQIPEQDETYLEDSFCVDEEESCKGQSSE 1540 1550 1560 1570 1580 1590 1630 1640 1650 1660 1670 1680 pF1KE2 EEVCVDFNLITDDCFANSKKYKTRRAVMLKEMMEQNCAHSKKKLSRIILPDDSSEEENNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EEVCVDFNLITDDCFANSKKYKTRRAVMLKEMMEQNCAHSKKKLSRIILPDDSSEEENNV 1600 1610 1620 1630 1640 1650 1690 1700 1710 1720 1730 1740 pF1KE2 NDKRESNIAVNPSTVKKNKQQDHCLNSVPSGSSAQSKVRSTPRVNPLAKQSKQTSLNLKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NDKRESNIAVNPSTVKKNKQQDHCLNSVPSGSSAQSKVRSTPRVNPLAKQSKQTSLNLKD 1660 1670 1680 1690 1700 1710 1750 1760 1770 1780 1790 1800 pF1KE2 TISEVSDFKPQNHNEVQSTTPPFTTVDSQKDCRKFPVPQKDGSALEDSSTSGASCSKSRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TISEVSDFKPQNHNEVQSTTPPFTTVDSQKDCRKFPVPQKDGSALEDSSTSGASCSKSRP 1720 1730 1740 1750 1760 1770 1810 1820 1830 1840 1850 1860 pF1KE2 HLAGTHTSLRLAQEGKGTCILVGGHEITSGLEVISSLRAIHGLQVEVCPLNGCDYIVSNR ::::::::::: :::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HLAGTHTSLRLPQEGKGTCILVGGHEITSGLEVISSLRAIHGLQVEVCPLNGCDYIVSNR 1780 1790 1800 1810 1820 1830 1870 1880 1890 1900 1910 1920 pF1KE2 MVVERRSQSEMLNSVNKNKFIEQIQHLQSMFERICVIVEKDREKTGDTSRMFRRTKSYDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MVVERRSQSEMLNSVNKNKFIEQIQHLQSMFERICVIVEKDREKTGDTSRMFRRTKSYDS 1840 1850 1860 1870 1880 1890 1930 1940 1950 1960 1970 1980 pF1KE2 LLTTLIGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVNSNKSEALQFYLSIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLTTLIGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVNSNKSEALQFYLSIP 1900 1910 1920 1930 1940 1950 1990 2000 2010 2020 2030 2040 pF1KE2 NISYITALNMCHQFSSVKRMANSSLQEISMYAQVTHQKAEEIYRYIHYVFDIQMLPNDLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NISYITALNMCHQFSSVKRMANSSLQEISMYAQVTHQKAEEIYRYIHYVFDIQMLPNDLN 1960 1970 1980 1990 2000 2010 pF1KE2 QDRLKSDI :::::::: NP_001 QDRLKSDI 2020 >>XP_016877012 (OMIM: 189960,609644,614087) PREDICTED: F (1801 aa) initn: 9647 init1: 9647 opt: 11726 Z-score: 10430.5 bits: 1943.4 E(85289): 0 Smith-Waterman score: 11726; 99.1% identity (99.3% similar) in 1799 aa overlap (1-1794:1-1799) 10 20 30 40 50 60 pF1KE2 MSGRQRTLFQTWGSSISRSSGTPGCSSGTERPQSPGSSKAPLPAAAEAQLESDDDVLLVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSGRQRTLFQTWGSSISRSSGTPGCSSGTERPQSPGSSKAPLPAAAEAQLESDDDVLLVA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 AYEAERQLCLENGGFCTSAGALWIYPTNCPVRDYQLHISRAALFCNTLVCLPTGLGKTFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AYEAERQLCLENGGFCTSAGALWIYPTNCPVRDYQLHISRAALFCNTLVCLPTGLGKTFI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 AAVVMYNFYRWFPSGKVVFMAPTKPLVTQQIEACYQVMGIPQSHMAEMTGSTQASTRKEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AAVVMYNFYRWFPSGKVVFMAPTKPLVTQQIEACYQVMGIPQSHMAEMTGSTQASTRKEI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 WCSKRVLFLTPQVMVNDLSRGACPAAEIKCLVIDEAHKALGNYAYCQVVRELVKYTNHFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WCSKRVLFLTPQVMVNDLSRGACPAAEIKCLVIDEAHKALGNYAYCQVVRELVKYTNHFR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 ILALSATPGSDIKAVQQVITNLLIGQIELRSEDSPDILTYSHERKVEKLIVPLGEELAAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ILALSATPGSDIKAVQQVITNLLIGQIELRSEDSPDILTYSHERKVEKLIVPLGEELAAI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 QKTYIQILESFARSLIQRNVLMRRDIPNLTKYQIILARDQFRKNPSPNIVGIQQGIIEGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QKTYIQILESFARSLIQRNVLMRRDIPNLTKYQIILARDQFRKNPSPNIVGIQQGIIEGE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 FAICISLYHGYELLQQMGMRSLYFFLCGIMDGTKGMTRSKNELGRNEDFMKLYNHLECMF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FAICISLYHGYELLQQMGMRSLYFFLCGIMDGTKGMTRSKNELGRNEDFMKLYNHLECMF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 ARTRSTSANGISAIQQGDKNKKFVYSHPKLKKLEEVVIEHFKSWNAENTTEKKRDETRVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ARTRSTSANGISAIQQGDKNKKFVYSHPKLKKLEEVVIEHFKSWNAENTTEKKRDETRVM 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 IFSSFRDSVQEIAEMLSQHQPIIRVMTFVGHASGKSTKGFTQKEQLEVVKQFRDGGYNTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IFSSFRDSVQEIAEMLSQHQPIIRVMTFVGHASGKSTKGFTQKEQLEVVKQFRDGGYNTL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 VSTCVGEEGLDIGEVDLIICFDSQKSPIRLVQRMGRTGRKRQGRIVIILSEGREERIYNQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VSTCVGEEGLDIGEVDLIICFDSQKSPIRLVQRMGRTGRKRQGRIVIILSEGREERIYNQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 SQSNKRSIYKAISSNRQVLHFYQRSPRMVPDGINPKLHKMFITHGVYEPEKPSRNLQRKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SQSNKRSIYKAISSNRQVLHFYQRSPRMVPDGINPKLHKMFITHGVYEPEKPSRNLQRKS 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 SIFSYRDGMRQSSLKKDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQVQFSSLQNEENKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SIFSYRDGMRQSSLKKDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQVQFSSLQNEENKP 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 AQESTTGIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIEGMRHEEGECSYELE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AQESTTGIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIEGMRHEEGECSYELE 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 VESYLQMEDVTSTFIAPRNESNNLASDTFITHKKSSFIKNINQGSSSSVIESDEECAEIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VESYLQMEDVTSTFIAPRNESNNLASDTFITHKKSSFIKNINQGSSSSVIESDEECAEIV 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE2 KQTHIKPTKIVSLKKKVSKEIKKDQLKKENNHGIIDSLDNDRNSTVENIFQEDLPNDKRT :::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::: XP_016 KQTHIKPTKIVSLKKKVSKEIKKDQLKKENNHGIIDSVDNDRNSTVENIFQEDLPNDKRT 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE2 SDTDEIAATCTINENVIKEPCVLLTECQFTNKSTSSLAGNVLDSGYNSFNDEKSVSSNLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SDTDEIAATCTINENVIKEPCVLLTECQFTNKSTSSLAGNVLDSGYNSFNDEKSVSSNLF 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE2 LPFEEELYIVRTDDQFYNCHSLTKEVLANVERFLSYSPPPLSGLSDLEYEIAKGTALENL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPFEEELYIVRTDDQFYNCHSLTKEVLANVERFLSYSPPPLSGLSDLEYEIAKGTALENL 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE2 LFLPCAEHLRSDKCTCLLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPNDNISDEPSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LFLPCAEHLRSDKCTCLLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPNDNISDEPSL 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE2 CDCDVHKHNQNENLVPNNRVQIHRSPAQNLVGENNHDVDNSDLPVLSTDQDESLLLFEDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CDCDVHKHNQNENLVPNNRVQIHRSPAQNLVGENNHDVDNSDLPVLSTDQDESLLLFEDV 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE2 NTEFDDVSLSPLNSKSESLPVSDKTAISETPLVSQFLISDELLLDNNSELQDQITRDANS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NTEFDDVSLSPLNSKSESLPVSDKTAISETPLVSQFLISDELLLDNNSELQDQITRDANS 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KE2 FKSRDQRGVQEEKVKNHEDIFDCSRDLFSVTFDLGFCSPDSDDEILEHTSDSNRPLDDLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FKSRDQRGVQEEKVKNHEDIFDCSRDLFSVTFDLGFCSPDSDDEILEHTSDSNRPLDDLY 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KE2 GRYLEIKEISDANYVSNQALIPRDHSKNFTSGTVIIPSNEDMQNPNYVHLPLSAAKNEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GRYLEIKEISDANYVSNQALIPRDHSKNFTSGTVIIPSNEDMQNPNYVHLPLSAAKNEEL 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KE2 LSPGYSQFSLPVQKKVMSTPLSKSNTLNSFSKIRKEILKTPDSSKEKVNLQRFKEALNST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSPGYSQFSLPVQKKVMSTPLSKSNTLNSFSKIRKEILKTPDSSKEKVNLQRFKEALNST 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KE2 FDYSEFSLEKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEIFRRKVKRAKGNVLNSPED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FDYSEFSLEKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEIFRRKVKRAKGNVLNSPED 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 pF1KE2 QKNSEVDSPLHAVKKRRFPVNR-----SELSSSDESENFPKPCSQLEDFKVCNGNARRGI :::::::::::::::::::.:: ::::::::::::::::::::::::::::::::: XP_016 QKNSEVDSPLHAVKKRRFPINRVSKYQSELSSSDESENFPKPCSQLEDFKVCNGNARRGI 1450 1460 1470 1480 1490 1500 1500 1510 1520 1530 1540 1550 pF1KE2 KVPKRQSHLKHVARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDFLNDETQLSQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KVPKRQSHLKHVARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDFLNDETQLSQA 1510 1520 1530 1540 1550 1560 1560 1570 1580 1590 1600 1610 pF1KE2 INDSEMRAIYMKSLRSPMMNNKYKMIHKTHKNINIFSQIPEQDETYLEDSFCVDEEESCK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 INDSEMRAIYMKSLRSPMMNNKYKMIHKTHKNINIFSQIPEQDETYLEDSFCVDEEESCK 1570 1580 1590 1600 1610 1620 1620 1630 1640 1650 1660 1670 pF1KE2 GQSSEEEVCVDFNLITDDCFANSKKYKTRRAVMLKEMMEQNCAHSKKKLSRIILPDDSSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GQSSEEEVCVDFNLITDDCFANSKKYKTRRAVMLKEMMEQNCAHSKKKLSRIILPDDSSE 1630 1640 1650 1660 1670 1680 1680 1690 1700 1710 1720 1730 pF1KE2 EENNVNDKRESNIAVNPSTVKKNKQQDHCLNSVPSGSSAQSKVRSTPRVNPLAKQSKQTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EENNVNDKRESNIAVNPSTVKKNKQQDHCLNSVPSGSSAQSKVRSTPRVNPLAKQSKQTS 1690 1700 1710 1720 1730 1740 1740 1750 1760 1770 1780 1790 pF1KE2 LNLKDTISEVSDFKPQNHNEVQSTTPPFTTVDSQKDCRKFPVPQKDGSALEDSSTSGASC ::::::::::::::::::::::::::::::::::::::::::::: : ::..: XP_016 LNLKDTISEVSDFKPQNHNEVQSTTPPFTTVDSQKDCRKFPVPQKLTSRNLHVCTSNSSE 1750 1760 1770 1780 1790 1800 1800 1810 1820 1830 1840 1850 pF1KE2 SKSRPHLAGTHTSLRLAQEGKGTCILVGGHEITSGLEVISSLRAIHGLQVEVCPLNGCDY XP_016 G >>XP_011535337 (OMIM: 189960,609644,614087) PREDICTED: F (2027 aa) initn: 7933 init1: 7933 opt: 11726 Z-score: 10429.7 bits: 1943.4 E(85289): 0 Smith-Waterman score: 13217; 98.3% identity (98.4% similar) in 2053 aa overlap (1-2048:1-2027) 10 20 30 40 50 60 pF1KE2 MSGRQRTLFQTWGSSISRSSGTPGCSSGTERPQSPGSSKAPLPAAAEAQLESDDDVLLVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSGRQRTLFQTWGSSISRSSGTPGCSSGTERPQSPGSSKAPLPAAAEAQLESDDDVLLVA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 AYEAERQLCLENGGFCTSAGALWIYPTNCPVRDYQLHISRAALFCNTLVCLPTGLGKTFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AYEAERQLCLENGGFCTSAGALWIYPTNCPVRDYQLHISRAALFCNTLVCLPTGLGKTFI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 AAVVMYNFYRWFPSGKVVFMAPTKPLVTQQIEACYQVMGIPQSHMAEMTGSTQASTRKEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AAVVMYNFYRWFPSGKVVFMAPTKPLVTQQIEACYQVMGIPQSHMAEMTGSTQASTRKEI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 WCSKRVLFLTPQVMVNDLSRGACPAAEIKCLVIDEAHKALGNYAYCQVVRELVKYTNHFR ::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WCSKRVLFLTPQVMVNDLSRGACPAAEIKCLVIDEAHKALGNYAYCQ------------- 190 200 210 220 250 260 270 280 290 300 pF1KE2 ILALSATPGSDIKAVQQVITNLLIGQIELRSEDSPDILTYSHERKVEKLIVPLGEELAAI ::::::::::::::::::::::::::::::::::::::::::::::: XP_011 -------------AVQQVITNLLIGQIELRSEDSPDILTYSHERKVEKLIVPLGEELAAI 230 240 250 260 270 310 320 330 340 350 360 pF1KE2 QKTYIQILESFARSLIQRNVLMRRDIPNLTKYQIILARDQFRKNPSPNIVGIQQGIIEGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QKTYIQILESFARSLIQRNVLMRRDIPNLTKYQIILARDQFRKNPSPNIVGIQQGIIEGE 280 290 300 310 320 330 370 380 390 400 410 420 pF1KE2 FAICISLYHGYELLQQMGMRSLYFFLCGIMDGTKGMTRSKNELGRNEDFMKLYNHLECMF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FAICISLYHGYELLQQMGMRSLYFFLCGIMDGTKGMTRSKNELGRNEDFMKLYNHLECMF 340 350 360 370 380 390 430 440 450 460 470 480 pF1KE2 ARTRSTSANGISAIQQGDKNKKFVYSHPKLKKLEEVVIEHFKSWNAENTTEKKRDETRVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ARTRSTSANGISAIQQGDKNKKFVYSHPKLKKLEEVVIEHFKSWNAENTTEKKRDETRVM 400 410 420 430 440 450 490 500 510 520 530 540 pF1KE2 IFSSFRDSVQEIAEMLSQHQPIIRVMTFVGHASGKSTKGFTQKEQLEVVKQFRDGGYNTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IFSSFRDSVQEIAEMLSQHQPIIRVMTFVGHASGKSTKGFTQKEQLEVVKQFRDGGYNTL 460 470 480 490 500 510 550 560 570 580 590 600 pF1KE2 VSTCVGEEGLDIGEVDLIICFDSQKSPIRLVQRMGRTGRKRQGRIVIILSEGREERIYNQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VSTCVGEEGLDIGEVDLIICFDSQKSPIRLVQRMGRTGRKRQGRIVIILSEGREERIYNQ 520 530 540 550 560 570 610 620 630 640 650 660 pF1KE2 SQSNKRSIYKAISSNRQVLHFYQRSPRMVPDGINPKLHKMFITHGVYEPEKPSRNLQRKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SQSNKRSIYKAISSNRQVLHFYQRSPRMVPDGINPKLHKMFITHGVYEPEKPSRNLQRKS 580 590 600 610 620 630 670 680 690 700 710 720 pF1KE2 SIFSYRDGMRQSSLKKDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQVQFSSLQNEENKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SIFSYRDGMRQSSLKKDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQVQFSSLQNEENKP 640 650 660 670 680 690 730 740 750 760 770 780 pF1KE2 AQESTTGIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIEGMRHEEGECSYELE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AQESTTGIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIEGMRHEEGECSYELE 700 710 720 730 740 750 790 800 810 820 830 840 pF1KE2 VESYLQMEDVTSTFIAPRNESNNLASDTFITHKKSSFIKNINQGSSSSVIESDEECAEIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VESYLQMEDVTSTFIAPRNESNNLASDTFITHKKSSFIKNINQGSSSSVIESDEECAEIV 760 770 780 790 800 810 850 860 870 880 890 900 pF1KE2 KQTHIKPTKIVSLKKKVSKEIKKDQLKKENNHGIIDSLDNDRNSTVENIFQEDLPNDKRT :::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::: XP_011 KQTHIKPTKIVSLKKKVSKEIKKDQLKKENNHGIIDSVDNDRNSTVENIFQEDLPNDKRT 820 830 840 850 860 870 910 920 930 940 950 960 pF1KE2 SDTDEIAATCTINENVIKEPCVLLTECQFTNKSTSSLAGNVLDSGYNSFNDEKSVSSNLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SDTDEIAATCTINENVIKEPCVLLTECQFTNKSTSSLAGNVLDSGYNSFNDEKSVSSNLF 880 890 900 910 920 930 970 980 990 1000 1010 1020 pF1KE2 LPFEEELYIVRTDDQFYNCHSLTKEVLANVERFLSYSPPPLSGLSDLEYEIAKGTALENL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LPFEEELYIVRTDDQFYNCHSLTKEVLANVERFLSYSPPPLSGLSDLEYEIAKGTALENL 940 950 960 970 980 990 1030 1040 1050 1060 1070 1080 pF1KE2 LFLPCAEHLRSDKCTCLLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPNDNISDEPSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LFLPCAEHLRSDKCTCLLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPNDNISDEPSL 1000 1010 1020 1030 1040 1050 1090 1100 1110 1120 1130 1140 pF1KE2 CDCDVHKHNQNENLVPNNRVQIHRSPAQNLVGENNHDVDNSDLPVLSTDQDESLLLFEDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CDCDVHKHNQNENLVPNNRVQIHRSPAQNLVGENNHDVDNSDLPVLSTDQDESLLLFEDV 1060 1070 1080 1090 1100 1110 1150 1160 1170 1180 1190 1200 pF1KE2 NTEFDDVSLSPLNSKSESLPVSDKTAISETPLVSQFLISDELLLDNNSELQDQITRDANS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NTEFDDVSLSPLNSKSESLPVSDKTAISETPLVSQFLISDELLLDNNSELQDQITRDANS 1120 1130 1140 1150 1160 1170 1210 1220 1230 1240 1250 1260 pF1KE2 FKSRDQRGVQEEKVKNHEDIFDCSRDLFSVTFDLGFCSPDSDDEILEHTSDSNRPLDDLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FKSRDQRGVQEEKVKNHEDIFDCSRDLFSVTFDLGFCSPDSDDEILEHTSDSNRPLDDLY 1180 1190 1200 1210 1220 1230 1270 1280 1290 1300 1310 1320 pF1KE2 GRYLEIKEISDANYVSNQALIPRDHSKNFTSGTVIIPSNEDMQNPNYVHLPLSAAKNEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GRYLEIKEISDANYVSNQALIPRDHSKNFTSGTVIIPSNEDMQNPNYVHLPLSAAKNEEL 1240 1250 1260 1270 1280 1290 1330 1340 1350 1360 1370 1380 pF1KE2 LSPGYSQFSLPVQKKVMSTPLSKSNTLNSFSKIRKEILKTPDSSKEKVNLQRFKEALNST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSPGYSQFSLPVQKKVMSTPLSKSNTLNSFSKIRKEILKTPDSSKEKVNLQRFKEALNST 1300 1310 1320 1330 1340 1350 1390 1400 1410 1420 1430 1440 pF1KE2 FDYSEFSLEKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEIFRRKVKRAKGNVLNSPED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FDYSEFSLEKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEIFRRKVKRAKGNVLNSPED 1360 1370 1380 1390 1400 1410 1450 1460 1470 1480 1490 pF1KE2 QKNSEVDSPLHAVKKRRFPVNR-----SELSSSDESENFPKPCSQLEDFKVCNGNARRGI :::::::::::::::::::.:: ::::::::::::::::::::::::::::::::: XP_011 QKNSEVDSPLHAVKKRRFPINRVSKYQSELSSSDESENFPKPCSQLEDFKVCNGNARRGI 1420 1430 1440 1450 1460 1470 1500 1510 1520 1530 1540 1550 pF1KE2 KVPKRQSHLKHVARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDFLNDETQLSQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KVPKRQSHLKHVARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDFLNDETQLSQA 1480 1490 1500 1510 1520 1530 1560 1570 1580 1590 1600 1610 pF1KE2 INDSEMRAIYMKSLRSPMMNNKYKMIHKTHKNINIFSQIPEQDETYLEDSFCVDEEESCK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 INDSEMRAIYMKSLRSPMMNNKYKMIHKTHKNINIFSQIPEQDETYLEDSFCVDEEESCK 1540 1550 1560 1570 1580 1590 1620 1630 1640 1650 1660 1670 pF1KE2 GQSSEEEVCVDFNLITDDCFANSKKYKTRRAVMLKEMMEQNCAHSKKKLSRIILPDDSSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GQSSEEEVCVDFNLITDDCFANSKKYKTRRAVMLKEMMEQNCAHSKKKLSRIILPDDSSE 1600 1610 1620 1630 1640 1650 1680 1690 1700 1710 1720 1730 pF1KE2 EENNVNDKRESNIAVNPSTVKKNKQQDHCLNSVPSGSSAQSKVRSTPRVNPLAKQSKQTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EENNVNDKRESNIAVNPSTVKKNKQQDHCLNSVPSGSSAQSKVRSTPRVNPLAKQSKQTS 1660 1670 1680 1690 1700 1710 1740 1750 1760 1770 1780 1790 pF1KE2 LNLKDTISEVSDFKPQNHNEVQSTTPPFTTVDSQKDCRKFPVPQKDGSALEDSSTSGASC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LNLKDTISEVSDFKPQNHNEVQSTTPPFTTVDSQKDCRKFPVPQKDGSALEDSSTSGASC 1720 1730 1740 1750 1760 1770 1800 1810 1820 1830 1840 1850 pF1KE2 SKSRPHLAGTHTSLRLAQEGKGTCILVGGHEITSGLEVISSLRAIHGLQVEVCPLNGCDY :::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::: XP_011 SKSRPHLAGTHTSLRLPQEGKGTCILVGGHEITSGLEVISSLRAIHGLQVEVCPLNGCDY 1780 1790 1800 1810 1820 1830 1860 1870 1880 1890 1900 1910 pF1KE2 IVSNRMVVERRSQSEMLNSVNKNKFIEQIQHLQSMFERICVIVEKDREKTGDTSRMFRRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IVSNRMVVERRSQSEMLNSVNKNKFIEQIQHLQSMFERICVIVEKDREKTGDTSRMFRRT 1840 1850 1860 1870 1880 1890 1920 1930 1940 1950 1960 1970 pF1KE2 KSYDSLLTTLIGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVNSNKSEALQF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KSYDSLLTTLIGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVNSNKSEALQF 1900 1910 1920 1930 1940 1950 1980 1990 2000 2010 2020 2030 pF1KE2 YLSIPNISYITALNMCHQFSSVKRMANSSLQEISMYAQVTHQKAEEIYRYIHYVFDIQML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YLSIPNISYITALNMCHQFSSVKRMANSSLQEISMYAQVTHQKAEEIYRYIHYVFDIQML 1960 1970 1980 1990 2000 2010 2040 pF1KE2 PNDLNQDRLKSDI ::::::::::::: XP_011 PNDLNQDRLKSDI 2020 >>XP_016877013 (OMIM: 189960,609644,614087) PREDICTED: F (1732 aa) initn: 7521 init1: 7521 opt: 11314 Z-score: 10064.3 bits: 1875.6 E(85289): 0 Smith-Waterman score: 11314; 99.5% identity (99.7% similar) in 1732 aa overlap (322-2048:1-1732) 300 310 320 330 340 350 pF1KE2 PLGEELAAIQKTYIQILESFARSLIQRNVLMRRDIPNLTKYQIILARDQFRKNPSPNIVG :::::::::::::::::::::::::::::: XP_016 MRRDIPNLTKYQIILARDQFRKNPSPNIVG 10 20 30 360 370 380 390 400 410 pF1KE2 IQQGIIEGEFAICISLYHGYELLQQMGMRSLYFFLCGIMDGTKGMTRSKNELGRNEDFMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IQQGIIEGEFAICISLYHGYELLQQMGMRSLYFFLCGIMDGTKGMTRSKNELGRNEDFMK 40 50 60 70 80 90 420 430 440 450 460 470 pF1KE2 LYNHLECMFARTRSTSANGISAIQQGDKNKKFVYSHPKLKKLEEVVIEHFKSWNAENTTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LYNHLECMFARTRSTSANGISAIQQGDKNKKFVYSHPKLKKLEEVVIEHFKSWNAENTTE 100 110 120 130 140 150 480 490 500 510 520 530 pF1KE2 KKRDETRVMIFSSFRDSVQEIAEMLSQHQPIIRVMTFVGHASGKSTKGFTQKEQLEVVKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KKRDETRVMIFSSFRDSVQEIAEMLSQHQPIIRVMTFVGHASGKSTKGFTQKEQLEVVKQ 160 170 180 190 200 210 540 550 560 570 580 590 pF1KE2 FRDGGYNTLVSTCVGEEGLDIGEVDLIICFDSQKSPIRLVQRMGRTGRKRQGRIVIILSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FRDGGYNTLVSTCVGEEGLDIGEVDLIICFDSQKSPIRLVQRMGRTGRKRQGRIVIILSE 220 230 240 250 260 270 600 610 620 630 640 650 pF1KE2 GREERIYNQSQSNKRSIYKAISSNRQVLHFYQRSPRMVPDGINPKLHKMFITHGVYEPEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GREERIYNQSQSNKRSIYKAISSNRQVLHFYQRSPRMVPDGINPKLHKMFITHGVYEPEK 280 290 300 310 320 330 660 670 680 690 700 710 pF1KE2 PSRNLQRKSSIFSYRDGMRQSSLKKDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQVQFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSRNLQRKSSIFSYRDGMRQSSLKKDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQVQFS 340 350 360 370 380 390 720 730 740 750 760 770 pF1KE2 SLQNEENKPAQESTTGIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIEGMRHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLQNEENKPAQESTTGIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIEGMRHE 400 410 420 430 440 450 780 790 800 810 820 830 pF1KE2 EGECSYELEVESYLQMEDVTSTFIAPRNESNNLASDTFITHKKSSFIKNINQGSSSSVIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EGECSYELEVESYLQMEDVTSTFIAPRNESNNLASDTFITHKKSSFIKNINQGSSSSVIE 460 470 480 490 500 510 840 850 860 870 880 890 pF1KE2 SDEECAEIVKQTHIKPTKIVSLKKKVSKEIKKDQLKKENNHGIIDSLDNDRNSTVENIFQ ::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::: XP_016 SDEECAEIVKQTHIKPTKIVSLKKKVSKEIKKDQLKKENNHGIIDSVDNDRNSTVENIFQ 520 530 540 550 560 570 900 910 920 930 940 950 pF1KE2 EDLPNDKRTSDTDEIAATCTINENVIKEPCVLLTECQFTNKSTSSLAGNVLDSGYNSFND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EDLPNDKRTSDTDEIAATCTINENVIKEPCVLLTECQFTNKSTSSLAGNVLDSGYNSFND 580 590 600 610 620 630 960 970 980 990 1000 1010 pF1KE2 EKSVSSNLFLPFEEELYIVRTDDQFYNCHSLTKEVLANVERFLSYSPPPLSGLSDLEYEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKSVSSNLFLPFEEELYIVRTDDQFYNCHSLTKEVLANVERFLSYSPPPLSGLSDLEYEI 640 650 660 670 680 690 1020 1030 1040 1050 1060 1070 pF1KE2 AKGTALENLLFLPCAEHLRSDKCTCLLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AKGTALENLLFLPCAEHLRSDKCTCLLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPN 700 710 720 730 740 750 1080 1090 1100 1110 1120 1130 pF1KE2 DNISDEPSLCDCDVHKHNQNENLVPNNRVQIHRSPAQNLVGENNHDVDNSDLPVLSTDQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DNISDEPSLCDCDVHKHNQNENLVPNNRVQIHRSPAQNLVGENNHDVDNSDLPVLSTDQD 760 770 780 790 800 810 1140 1150 1160 1170 1180 1190 pF1KE2 ESLLLFEDVNTEFDDVSLSPLNSKSESLPVSDKTAISETPLVSQFLISDELLLDNNSELQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ESLLLFEDVNTEFDDVSLSPLNSKSESLPVSDKTAISETPLVSQFLISDELLLDNNSELQ 820 830 840 850 860 870 1200 1210 1220 1230 1240 1250 pF1KE2 DQITRDANSFKSRDQRGVQEEKVKNHEDIFDCSRDLFSVTFDLGFCSPDSDDEILEHTSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DQITRDANSFKSRDQRGVQEEKVKNHEDIFDCSRDLFSVTFDLGFCSPDSDDEILEHTSD 880 890 900 910 920 930 1260 1270 1280 1290 1300 1310 pF1KE2 SNRPLDDLYGRYLEIKEISDANYVSNQALIPRDHSKNFTSGTVIIPSNEDMQNPNYVHLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SNRPLDDLYGRYLEIKEISDANYVSNQALIPRDHSKNFTSGTVIIPSNEDMQNPNYVHLP 940 950 960 970 980 990 1320 1330 1340 1350 1360 1370 pF1KE2 LSAAKNEELLSPGYSQFSLPVQKKVMSTPLSKSNTLNSFSKIRKEILKTPDSSKEKVNLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSAAKNEELLSPGYSQFSLPVQKKVMSTPLSKSNTLNSFSKIRKEILKTPDSSKEKVNLQ 1000 1010 1020 1030 1040 1050 1380 1390 1400 1410 1420 1430 pF1KE2 RFKEALNSTFDYSEFSLEKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEIFRRKVKRAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RFKEALNSTFDYSEFSLEKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEIFRRKVKRAK 1060 1070 1080 1090 1100 1110 1440 1450 1460 1470 1480 pF1KE2 GNVLNSPEDQKNSEVDSPLHAVKKRRFPVNR-----SELSSSDESENFPKPCSQLEDFKV ::::::::::::::::::::::::::::.:: :::::::::::::::::::::::: XP_016 GNVLNSPEDQKNSEVDSPLHAVKKRRFPINRVSKYQSELSSSDESENFPKPCSQLEDFKV 1120 1130 1140 1150 1160 1170 1490 1500 1510 1520 1530 1540 pF1KE2 CNGNARRGIKVPKRQSHLKHVARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CNGNARRGIKVPKRQSHLKHVARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDFL 1180 1190 1200 1210 1220 1230 1550 1560 1570 1580 1590 1600 pF1KE2 NDETQLSQAINDSEMRAIYMKSLRSPMMNNKYKMIHKTHKNINIFSQIPEQDETYLEDSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NDETQLSQAINDSEMRAIYMKSLRSPMMNNKYKMIHKTHKNINIFSQIPEQDETYLEDSF 1240 1250 1260 1270 1280 1290 1610 1620 1630 1640 1650 1660 pF1KE2 CVDEEESCKGQSSEEEVCVDFNLITDDCFANSKKYKTRRAVMLKEMMEQNCAHSKKKLSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CVDEEESCKGQSSEEEVCVDFNLITDDCFANSKKYKTRRAVMLKEMMEQNCAHSKKKLSR 1300 1310 1320 1330 1340 1350 1670 1680 1690 1700 1710 1720 pF1KE2 IILPDDSSEEENNVNDKRESNIAVNPSTVKKNKQQDHCLNSVPSGSSAQSKVRSTPRVNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IILPDDSSEEENNVNDKRESNIAVNPSTVKKNKQQDHCLNSVPSGSSAQSKVRSTPRVNP 1360 1370 1380 1390 1400 1410 1730 1740 1750 1760 1770 1780 pF1KE2 LAKQSKQTSLNLKDTISEVSDFKPQNHNEVQSTTPPFTTVDSQKDCRKFPVPQKDGSALE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LAKQSKQTSLNLKDTISEVSDFKPQNHNEVQSTTPPFTTVDSQKDCRKFPVPQKDGSALE 1420 1430 1440 1450 1460 1470 1790 1800 1810 1820 1830 1840 pF1KE2 DSSTSGASCSKSRPHLAGTHTSLRLAQEGKGTCILVGGHEITSGLEVISSLRAIHGLQVE ::::::::::::::::::::::::: :::::::::::::::::::::::::::::::::: XP_016 DSSTSGASCSKSRPHLAGTHTSLRLPQEGKGTCILVGGHEITSGLEVISSLRAIHGLQVE 1480 1490 1500 1510 1520 1530 1850 1860 1870 1880 1890 1900 pF1KE2 VCPLNGCDYIVSNRMVVERRSQSEMLNSVNKNKFIEQIQHLQSMFERICVIVEKDREKTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VCPLNGCDYIVSNRMVVERRSQSEMLNSVNKNKFIEQIQHLQSMFERICVIVEKDREKTG 1540 1550 1560 1570 1580 1590 1910 1920 1930 1940 1950 1960 pF1KE2 DTSRMFRRTKSYDSLLTTLIGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DTSRMFRRTKSYDSLLTTLIGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVN 1600 1610 1620 1630 1640 1650 1970 1980 1990 2000 2010 2020 pF1KE2 SNKSEALQFYLSIPNISYITALNMCHQFSSVKRMANSSLQEISMYAQVTHQKAEEIYRYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SNKSEALQFYLSIPNISYITALNMCHQFSSVKRMANSSLQEISMYAQVTHQKAEEIYRYI 1660 1670 1680 1690 1700 1710 2030 2040 pF1KE2 HYVFDIQMLPNDLNQDRLKSDI :::::::::::::::::::::: XP_016 HYVFDIQMLPNDLNQDRLKSDI 1720 1730 >>XP_016877016 (OMIM: 189960,609644,614087) PREDICTED: F (1653 aa) initn: 10829 init1: 10829 opt: 10829 Z-score: 9633.1 bits: 1795.7 E(85289): 0 Smith-Waterman score: 10829; 99.8% identity (99.9% similar) in 1653 aa overlap (396-2048:1-1653) 370 380 390 400 410 420 pF1KE2 SLYHGYELLQQMGMRSLYFFLCGIMDGTKGMTRSKNELGRNEDFMKLYNHLECMFARTRS :::::::::::::::::::::::::::::: XP_016 MTRSKNELGRNEDFMKLYNHLECMFARTRS 10 20 30 430 440 450 460 470 480 pF1KE2 TSANGISAIQQGDKNKKFVYSHPKLKKLEEVVIEHFKSWNAENTTEKKRDETRVMIFSSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TSANGISAIQQGDKNKKFVYSHPKLKKLEEVVIEHFKSWNAENTTEKKRDETRVMIFSSF 40 50 60 70 80 90 490 500 510 520 530 540 pF1KE2 RDSVQEIAEMLSQHQPIIRVMTFVGHASGKSTKGFTQKEQLEVVKQFRDGGYNTLVSTCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RDSVQEIAEMLSQHQPIIRVMTFVGHASGKSTKGFTQKEQLEVVKQFRDGGYNTLVSTCV 100 110 120 130 140 150 550 560 570 580 590 600 pF1KE2 GEEGLDIGEVDLIICFDSQKSPIRLVQRMGRTGRKRQGRIVIILSEGREERIYNQSQSNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GEEGLDIGEVDLIICFDSQKSPIRLVQRMGRTGRKRQGRIVIILSEGREERIYNQSQSNK 160 170 180 190 200 210 610 620 630 640 650 660 pF1KE2 RSIYKAISSNRQVLHFYQRSPRMVPDGINPKLHKMFITHGVYEPEKPSRNLQRKSSIFSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSIYKAISSNRQVLHFYQRSPRMVPDGINPKLHKMFITHGVYEPEKPSRNLQRKSSIFSY 220 230 240 250 260 270 670 680 690 700 710 720 pF1KE2 RDGMRQSSLKKDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQVQFSSLQNEENKPAQEST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RDGMRQSSLKKDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQVQFSSLQNEENKPAQEST 280 290 300 310 320 330 730 740 750 760 770 780 pF1KE2 TGIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIEGMRHEEGECSYELEVESYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TGIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIEGMRHEEGECSYELEVESYL 340 350 360 370 380 390 790 800 810 820 830 840 pF1KE2 QMEDVTSTFIAPRNESNNLASDTFITHKKSSFIKNINQGSSSSVIESDEECAEIVKQTHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QMEDVTSTFIAPRNESNNLASDTFITHKKSSFIKNINQGSSSSVIESDEECAEIVKQTHI 400 410 420 430 440 450 850 860 870 880 890 900 pF1KE2 KPTKIVSLKKKVSKEIKKDQLKKENNHGIIDSLDNDRNSTVENIFQEDLPNDKRTSDTDE ::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::: XP_016 KPTKIVSLKKKVSKEIKKDQLKKENNHGIIDSVDNDRNSTVENIFQEDLPNDKRTSDTDE 460 470 480 490 500 510 910 920 930 940 950 960 pF1KE2 IAATCTINENVIKEPCVLLTECQFTNKSTSSLAGNVLDSGYNSFNDEKSVSSNLFLPFEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IAATCTINENVIKEPCVLLTECQFTNKSTSSLAGNVLDSGYNSFNDEKSVSSNLFLPFEE 520 530 540 550 560 570 970 980 990 1000 1010 1020 pF1KE2 ELYIVRTDDQFYNCHSLTKEVLANVERFLSYSPPPLSGLSDLEYEIAKGTALENLLFLPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELYIVRTDDQFYNCHSLTKEVLANVERFLSYSPPPLSGLSDLEYEIAKGTALENLLFLPC 580 590 600 610 620 630 1030 1040 1050 1060 1070 1080 pF1KE2 AEHLRSDKCTCLLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPNDNISDEPSLCDCDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AEHLRSDKCTCLLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPNDNISDEPSLCDCDV 640 650 660 670 680 690 1090 1100 1110 1120 1130 1140 pF1KE2 HKHNQNENLVPNNRVQIHRSPAQNLVGENNHDVDNSDLPVLSTDQDESLLLFEDVNTEFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HKHNQNENLVPNNRVQIHRSPAQNLVGENNHDVDNSDLPVLSTDQDESLLLFEDVNTEFD 700 710 720 730 740 750 1150 1160 1170 1180 1190 1200 pF1KE2 DVSLSPLNSKSESLPVSDKTAISETPLVSQFLISDELLLDNNSELQDQITRDANSFKSRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DVSLSPLNSKSESLPVSDKTAISETPLVSQFLISDELLLDNNSELQDQITRDANSFKSRD 760 770 780 790 800 810 1210 1220 1230 1240 1250 1260 pF1KE2 QRGVQEEKVKNHEDIFDCSRDLFSVTFDLGFCSPDSDDEILEHTSDSNRPLDDLYGRYLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QRGVQEEKVKNHEDIFDCSRDLFSVTFDLGFCSPDSDDEILEHTSDSNRPLDDLYGRYLE 820 830 840 850 860 870 1270 1280 1290 1300 1310 1320 pF1KE2 IKEISDANYVSNQALIPRDHSKNFTSGTVIIPSNEDMQNPNYVHLPLSAAKNEELLSPGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IKEISDANYVSNQALIPRDHSKNFTSGTVIIPSNEDMQNPNYVHLPLSAAKNEELLSPGY 880 890 900 910 920 930 1330 1340 1350 1360 1370 1380 pF1KE2 SQFSLPVQKKVMSTPLSKSNTLNSFSKIRKEILKTPDSSKEKVNLQRFKEALNSTFDYSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SQFSLPVQKKVMSTPLSKSNTLNSFSKIRKEILKTPDSSKEKVNLQRFKEALNSTFDYSE 940 950 960 970 980 990 1390 1400 1410 1420 1430 1440 pF1KE2 FSLEKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEIFRRKVKRAKGNVLNSPEDQKNSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FSLEKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEIFRRKVKRAKGNVLNSPEDQKNSE 1000 1010 1020 1030 1040 1050 1450 1460 1470 1480 1490 1500 pF1KE2 VDSPLHAVKKRRFPVNRSELSSSDESENFPKPCSQLEDFKVCNGNARRGIKVPKRQSHLK ::::::::::::::.::::::::::::::::::::::::::::::::::::::::::::: XP_016 VDSPLHAVKKRRFPINRSELSSSDESENFPKPCSQLEDFKVCNGNARRGIKVPKRQSHLK 1060 1070 1080 1090 1100 1110 1510 1520 1530 1540 1550 1560 pF1KE2 HVARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDFLNDETQLSQAINDSEMRAIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HVARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDFLNDETQLSQAINDSEMRAIY 1120 1130 1140 1150 1160 1170 1570 1580 1590 1600 1610 1620 pF1KE2 MKSLRSPMMNNKYKMIHKTHKNINIFSQIPEQDETYLEDSFCVDEEESCKGQSSEEEVCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MKSLRSPMMNNKYKMIHKTHKNINIFSQIPEQDETYLEDSFCVDEEESCKGQSSEEEVCV 1180 1190 1200 1210 1220 1230 1630 1640 1650 1660 1670 1680 pF1KE2 DFNLITDDCFANSKKYKTRRAVMLKEMMEQNCAHSKKKLSRIILPDDSSEEENNVNDKRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DFNLITDDCFANSKKYKTRRAVMLKEMMEQNCAHSKKKLSRIILPDDSSEEENNVNDKRE 1240 1250 1260 1270 1280 1290 1690 1700 1710 1720 1730 1740 pF1KE2 SNIAVNPSTVKKNKQQDHCLNSVPSGSSAQSKVRSTPRVNPLAKQSKQTSLNLKDTISEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SNIAVNPSTVKKNKQQDHCLNSVPSGSSAQSKVRSTPRVNPLAKQSKQTSLNLKDTISEV 1300 1310 1320 1330 1340 1350 1750 1760 1770 1780 1790 1800 pF1KE2 SDFKPQNHNEVQSTTPPFTTVDSQKDCRKFPVPQKDGSALEDSSTSGASCSKSRPHLAGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SDFKPQNHNEVQSTTPPFTTVDSQKDCRKFPVPQKDGSALEDSSTSGASCSKSRPHLAGT 1360 1370 1380 1390 1400 1410 1810 1820 1830 1840 1850 1860 pF1KE2 HTSLRLAQEGKGTCILVGGHEITSGLEVISSLRAIHGLQVEVCPLNGCDYIVSNRMVVER :::::: ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HTSLRLPQEGKGTCILVGGHEITSGLEVISSLRAIHGLQVEVCPLNGCDYIVSNRMVVER 1420 1430 1440 1450 1460 1470 1870 1880 1890 1900 1910 1920 pF1KE2 RSQSEMLNSVNKNKFIEQIQHLQSMFERICVIVEKDREKTGDTSRMFRRTKSYDSLLTTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSQSEMLNSVNKNKFIEQIQHLQSMFERICVIVEKDREKTGDTSRMFRRTKSYDSLLTTL 1480 1490 1500 1510 1520 1530 1930 1940 1950 1960 1970 1980 pF1KE2 IGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVNSNKSEALQFYLSIPNISYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVNSNKSEALQFYLSIPNISYI 1540 1550 1560 1570 1580 1590 1990 2000 2010 2020 2030 2040 pF1KE2 TALNMCHQFSSVKRMANSSLQEISMYAQVTHQKAEEIYRYIHYVFDIQMLPNDLNQDRLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TALNMCHQFSSVKRMANSSLQEISMYAQVTHQKAEEIYRYIHYVFDIQMLPNDLNQDRLK 1600 1610 1620 1630 1640 1650 pF1KE2 SDI ::: XP_016 SDI >>XP_016877014 (OMIM: 189960,609644,614087) PREDICTED: F (1658 aa) initn: 7016 init1: 7016 opt: 10809 Z-score: 9615.3 bits: 1792.4 E(85289): 0 Smith-Waterman score: 10809; 99.5% identity (99.6% similar) in 1658 aa overlap (396-2048:1-1658) 370 380 390 400 410 420 pF1KE2 SLYHGYELLQQMGMRSLYFFLCGIMDGTKGMTRSKNELGRNEDFMKLYNHLECMFARTRS :::::::::::::::::::::::::::::: XP_016 MTRSKNELGRNEDFMKLYNHLECMFARTRS 10 20 30 430 440 450 460 470 480 pF1KE2 TSANGISAIQQGDKNKKFVYSHPKLKKLEEVVIEHFKSWNAENTTEKKRDETRVMIFSSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TSANGISAIQQGDKNKKFVYSHPKLKKLEEVVIEHFKSWNAENTTEKKRDETRVMIFSSF 40 50 60 70 80 90 490 500 510 520 530 540 pF1KE2 RDSVQEIAEMLSQHQPIIRVMTFVGHASGKSTKGFTQKEQLEVVKQFRDGGYNTLVSTCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RDSVQEIAEMLSQHQPIIRVMTFVGHASGKSTKGFTQKEQLEVVKQFRDGGYNTLVSTCV 100 110 120 130 140 150 550 560 570 580 590 600 pF1KE2 GEEGLDIGEVDLIICFDSQKSPIRLVQRMGRTGRKRQGRIVIILSEGREERIYNQSQSNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GEEGLDIGEVDLIICFDSQKSPIRLVQRMGRTGRKRQGRIVIILSEGREERIYNQSQSNK 160 170 180 190 200 210 610 620 630 640 650 660 pF1KE2 RSIYKAISSNRQVLHFYQRSPRMVPDGINPKLHKMFITHGVYEPEKPSRNLQRKSSIFSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSIYKAISSNRQVLHFYQRSPRMVPDGINPKLHKMFITHGVYEPEKPSRNLQRKSSIFSY 220 230 240 250 260 270 670 680 690 700 710 720 pF1KE2 RDGMRQSSLKKDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQVQFSSLQNEENKPAQEST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RDGMRQSSLKKDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQVQFSSLQNEENKPAQEST 280 290 300 310 320 330 730 740 750 760 770 780 pF1KE2 TGIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIEGMRHEEGECSYELEVESYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TGIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIEGMRHEEGECSYELEVESYL 340 350 360 370 380 390 790 800 810 820 830 840 pF1KE2 QMEDVTSTFIAPRNESNNLASDTFITHKKSSFIKNINQGSSSSVIESDEECAEIVKQTHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QMEDVTSTFIAPRNESNNLASDTFITHKKSSFIKNINQGSSSSVIESDEECAEIVKQTHI 400 410 420 430 440 450 850 860 870 880 890 900 pF1KE2 KPTKIVSLKKKVSKEIKKDQLKKENNHGIIDSLDNDRNSTVENIFQEDLPNDKRTSDTDE ::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::: XP_016 KPTKIVSLKKKVSKEIKKDQLKKENNHGIIDSVDNDRNSTVENIFQEDLPNDKRTSDTDE 460 470 480 490 500 510 910 920 930 940 950 960 pF1KE2 IAATCTINENVIKEPCVLLTECQFTNKSTSSLAGNVLDSGYNSFNDEKSVSSNLFLPFEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IAATCTINENVIKEPCVLLTECQFTNKSTSSLAGNVLDSGYNSFNDEKSVSSNLFLPFEE 520 530 540 550 560 570 970 980 990 1000 1010 1020 pF1KE2 ELYIVRTDDQFYNCHSLTKEVLANVERFLSYSPPPLSGLSDLEYEIAKGTALENLLFLPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELYIVRTDDQFYNCHSLTKEVLANVERFLSYSPPPLSGLSDLEYEIAKGTALENLLFLPC 580 590 600 610 620 630 1030 1040 1050 1060 1070 1080 pF1KE2 AEHLRSDKCTCLLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPNDNISDEPSLCDCDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AEHLRSDKCTCLLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPNDNISDEPSLCDCDV 640 650 660 670 680 690 1090 1100 1110 1120 1130 1140 pF1KE2 HKHNQNENLVPNNRVQIHRSPAQNLVGENNHDVDNSDLPVLSTDQDESLLLFEDVNTEFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HKHNQNENLVPNNRVQIHRSPAQNLVGENNHDVDNSDLPVLSTDQDESLLLFEDVNTEFD 700 710 720 730 740 750 1150 1160 1170 1180 1190 1200 pF1KE2 DVSLSPLNSKSESLPVSDKTAISETPLVSQFLISDELLLDNNSELQDQITRDANSFKSRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DVSLSPLNSKSESLPVSDKTAISETPLVSQFLISDELLLDNNSELQDQITRDANSFKSRD 760 770 780 790 800 810 1210 1220 1230 1240 1250 1260 pF1KE2 QRGVQEEKVKNHEDIFDCSRDLFSVTFDLGFCSPDSDDEILEHTSDSNRPLDDLYGRYLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QRGVQEEKVKNHEDIFDCSRDLFSVTFDLGFCSPDSDDEILEHTSDSNRPLDDLYGRYLE 820 830 840 850 860 870 1270 1280 1290 1300 1310 1320 pF1KE2 IKEISDANYVSNQALIPRDHSKNFTSGTVIIPSNEDMQNPNYVHLPLSAAKNEELLSPGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IKEISDANYVSNQALIPRDHSKNFTSGTVIIPSNEDMQNPNYVHLPLSAAKNEELLSPGY 880 890 900 910 920 930 1330 1340 1350 1360 1370 1380 pF1KE2 SQFSLPVQKKVMSTPLSKSNTLNSFSKIRKEILKTPDSSKEKVNLQRFKEALNSTFDYSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SQFSLPVQKKVMSTPLSKSNTLNSFSKIRKEILKTPDSSKEKVNLQRFKEALNSTFDYSE 940 950 960 970 980 990 1390 1400 1410 1420 1430 1440 pF1KE2 FSLEKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEIFRRKVKRAKGNVLNSPEDQKNSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FSLEKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEIFRRKVKRAKGNVLNSPEDQKNSE 1000 1010 1020 1030 1040 1050 1450 1460 1470 1480 1490 1500 pF1KE2 VDSPLHAVKKRRFPVNR-----SELSSSDESENFPKPCSQLEDFKVCNGNARRGIKVPKR ::::::::::::::.:: :::::::::::::::::::::::::::::::::::::: XP_016 VDSPLHAVKKRRFPINRVSKYQSELSSSDESENFPKPCSQLEDFKVCNGNARRGIKVPKR 1060 1070 1080 1090 1100 1110 1510 1520 1530 1540 1550 1560 pF1KE2 QSHLKHVARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDFLNDETQLSQAINDSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QSHLKHVARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDFLNDETQLSQAINDSE 1120 1130 1140 1150 1160 1170 1570 1580 1590 1600 1610 1620 pF1KE2 MRAIYMKSLRSPMMNNKYKMIHKTHKNINIFSQIPEQDETYLEDSFCVDEEESCKGQSSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MRAIYMKSLRSPMMNNKYKMIHKTHKNINIFSQIPEQDETYLEDSFCVDEEESCKGQSSE 1180 1190 1200 1210 1220 1230 1630 1640 1650 1660 1670 1680 pF1KE2 EEVCVDFNLITDDCFANSKKYKTRRAVMLKEMMEQNCAHSKKKLSRIILPDDSSEEENNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EEVCVDFNLITDDCFANSKKYKTRRAVMLKEMMEQNCAHSKKKLSRIILPDDSSEEENNV 1240 1250 1260 1270 1280 1290 1690 1700 1710 1720 1730 1740 pF1KE2 NDKRESNIAVNPSTVKKNKQQDHCLNSVPSGSSAQSKVRSTPRVNPLAKQSKQTSLNLKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NDKRESNIAVNPSTVKKNKQQDHCLNSVPSGSSAQSKVRSTPRVNPLAKQSKQTSLNLKD 1300 1310 1320 1330 1340 1350 1750 1760 1770 1780 1790 1800 pF1KE2 TISEVSDFKPQNHNEVQSTTPPFTTVDSQKDCRKFPVPQKDGSALEDSSTSGASCSKSRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TISEVSDFKPQNHNEVQSTTPPFTTVDSQKDCRKFPVPQKDGSALEDSSTSGASCSKSRP 1360 1370 1380 1390 1400 1410 1810 1820 1830 1840 1850 1860 pF1KE2 HLAGTHTSLRLAQEGKGTCILVGGHEITSGLEVISSLRAIHGLQVEVCPLNGCDYIVSNR ::::::::::: :::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HLAGTHTSLRLPQEGKGTCILVGGHEITSGLEVISSLRAIHGLQVEVCPLNGCDYIVSNR 1420 1430 1440 1450 1460 1470 1870 1880 1890 1900 1910 1920 pF1KE2 MVVERRSQSEMLNSVNKNKFIEQIQHLQSMFERICVIVEKDREKTGDTSRMFRRTKSYDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MVVERRSQSEMLNSVNKNKFIEQIQHLQSMFERICVIVEKDREKTGDTSRMFRRTKSYDS 1480 1490 1500 1510 1520 1530 1930 1940 1950 1960 1970 1980 pF1KE2 LLTTLIGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVNSNKSEALQFYLSIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLTTLIGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVNSNKSEALQFYLSIP 1540 1550 1560 1570 1580 1590 1990 2000 2010 2020 2030 2040 pF1KE2 NISYITALNMCHQFSSVKRMANSSLQEISMYAQVTHQKAEEIYRYIHYVFDIQMLPNDLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NISYITALNMCHQFSSVKRMANSSLQEISMYAQVTHQKAEEIYRYIHYVFDIQMLPNDLN 1600 1610 1620 1630 1640 1650 pF1KE2 QDRLKSDI :::::::: XP_016 QDRLKSDI >>XP_016877015 (OMIM: 189960,609644,614087) PREDICTED: F (1658 aa) initn: 7016 init1: 7016 opt: 10809 Z-score: 9615.3 bits: 1792.4 E(85289): 0 Smith-Waterman score: 10809; 99.5% identity (99.6% similar) in 1658 aa overlap (396-2048:1-1658) 370 380 390 400 410 420 pF1KE2 SLYHGYELLQQMGMRSLYFFLCGIMDGTKGMTRSKNELGRNEDFMKLYNHLECMFARTRS :::::::::::::::::::::::::::::: XP_016 MTRSKNELGRNEDFMKLYNHLECMFARTRS 10 20 30 430 440 450 460 470 480 pF1KE2 TSANGISAIQQGDKNKKFVYSHPKLKKLEEVVIEHFKSWNAENTTEKKRDETRVMIFSSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TSANGISAIQQGDKNKKFVYSHPKLKKLEEVVIEHFKSWNAENTTEKKRDETRVMIFSSF 40 50 60 70 80 90 490 500 510 520 530 540 pF1KE2 RDSVQEIAEMLSQHQPIIRVMTFVGHASGKSTKGFTQKEQLEVVKQFRDGGYNTLVSTCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RDSVQEIAEMLSQHQPIIRVMTFVGHASGKSTKGFTQKEQLEVVKQFRDGGYNTLVSTCV 100 110 120 130 140 150 550 560 570 580 590 600 pF1KE2 GEEGLDIGEVDLIICFDSQKSPIRLVQRMGRTGRKRQGRIVIILSEGREERIYNQSQSNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GEEGLDIGEVDLIICFDSQKSPIRLVQRMGRTGRKRQGRIVIILSEGREERIYNQSQSNK 160 170 180 190 200 210 610 620 630 640 650 660 pF1KE2 RSIYKAISSNRQVLHFYQRSPRMVPDGINPKLHKMFITHGVYEPEKPSRNLQRKSSIFSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSIYKAISSNRQVLHFYQRSPRMVPDGINPKLHKMFITHGVYEPEKPSRNLQRKSSIFSY 220 230 240 250 260 270 670 680 690 700 710 720 pF1KE2 RDGMRQSSLKKDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQVQFSSLQNEENKPAQEST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RDGMRQSSLKKDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQVQFSSLQNEENKPAQEST 280 290 300 310 320 330 730 740 750 760 770 780 pF1KE2 TGIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIEGMRHEEGECSYELEVESYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TGIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIEGMRHEEGECSYELEVESYL 340 350 360 370 380 390 790 800 810 820 830 840 pF1KE2 QMEDVTSTFIAPRNESNNLASDTFITHKKSSFIKNINQGSSSSVIESDEECAEIVKQTHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QMEDVTSTFIAPRNESNNLASDTFITHKKSSFIKNINQGSSSSVIESDEECAEIVKQTHI 400 410 420 430 440 450 850 860 870 880 890 900 pF1KE2 KPTKIVSLKKKVSKEIKKDQLKKENNHGIIDSLDNDRNSTVENIFQEDLPNDKRTSDTDE ::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::: XP_016 KPTKIVSLKKKVSKEIKKDQLKKENNHGIIDSVDNDRNSTVENIFQEDLPNDKRTSDTDE 460 470 480 490 500 510 910 920 930 940 950 960 pF1KE2 IAATCTINENVIKEPCVLLTECQFTNKSTSSLAGNVLDSGYNSFNDEKSVSSNLFLPFEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IAATCTINENVIKEPCVLLTECQFTNKSTSSLAGNVLDSGYNSFNDEKSVSSNLFLPFEE 520 530 540 550 560 570 970 980 990 1000 1010 1020 pF1KE2 ELYIVRTDDQFYNCHSLTKEVLANVERFLSYSPPPLSGLSDLEYEIAKGTALENLLFLPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELYIVRTDDQFYNCHSLTKEVLANVERFLSYSPPPLSGLSDLEYEIAKGTALENLLFLPC 580 590 600 610 620 630 1030 1040 1050 1060 1070 1080 pF1KE2 AEHLRSDKCTCLLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPNDNISDEPSLCDCDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AEHLRSDKCTCLLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPNDNISDEPSLCDCDV 640 650 660 670 680 690 1090 1100 1110 1120 1130 1140 pF1KE2 HKHNQNENLVPNNRVQIHRSPAQNLVGENNHDVDNSDLPVLSTDQDESLLLFEDVNTEFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HKHNQNENLVPNNRVQIHRSPAQNLVGENNHDVDNSDLPVLSTDQDESLLLFEDVNTEFD 700 710 720 730 740 750 1150 1160 1170 1180 1190 1200 pF1KE2 DVSLSPLNSKSESLPVSDKTAISETPLVSQFLISDELLLDNNSELQDQITRDANSFKSRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DVSLSPLNSKSESLPVSDKTAISETPLVSQFLISDELLLDNNSELQDQITRDANSFKSRD 760 770 780 790 800 810 1210 1220 1230 1240 1250 1260 pF1KE2 QRGVQEEKVKNHEDIFDCSRDLFSVTFDLGFCSPDSDDEILEHTSDSNRPLDDLYGRYLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QRGVQEEKVKNHEDIFDCSRDLFSVTFDLGFCSPDSDDEILEHTSDSNRPLDDLYGRYLE 820 830 840 850 860 870 1270 1280 1290 1300 1310 1320 pF1KE2 IKEISDANYVSNQALIPRDHSKNFTSGTVIIPSNEDMQNPNYVHLPLSAAKNEELLSPGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IKEISDANYVSNQALIPRDHSKNFTSGTVIIPSNEDMQNPNYVHLPLSAAKNEELLSPGY 880 890 900 910 920 930 1330 1340 1350 1360 1370 1380 pF1KE2 SQFSLPVQKKVMSTPLSKSNTLNSFSKIRKEILKTPDSSKEKVNLQRFKEALNSTFDYSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SQFSLPVQKKVMSTPLSKSNTLNSFSKIRKEILKTPDSSKEKVNLQRFKEALNSTFDYSE 940 950 960 970 980 990 1390 1400 1410 1420 1430 1440 pF1KE2 FSLEKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEIFRRKVKRAKGNVLNSPEDQKNSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FSLEKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEIFRRKVKRAKGNVLNSPEDQKNSE 1000 1010 1020 1030 1040 1050 1450 1460 1470 1480 1490 1500 pF1KE2 VDSPLHAVKKRRFPVNR-----SELSSSDESENFPKPCSQLEDFKVCNGNARRGIKVPKR ::::::::::::::.:: :::::::::::::::::::::::::::::::::::::: XP_016 VDSPLHAVKKRRFPINRVSKYQSELSSSDESENFPKPCSQLEDFKVCNGNARRGIKVPKR 1060 1070 1080 1090 1100 1110 1510 1520 1530 1540 1550 1560 pF1KE2 QSHLKHVARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDFLNDETQLSQAINDSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QSHLKHVARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDFLNDETQLSQAINDSE 1120 1130 1140 1150 1160 1170 1570 1580 1590 1600 1610 1620 pF1KE2 MRAIYMKSLRSPMMNNKYKMIHKTHKNINIFSQIPEQDETYLEDSFCVDEEESCKGQSSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MRAIYMKSLRSPMMNNKYKMIHKTHKNINIFSQIPEQDETYLEDSFCVDEEESCKGQSSE 1180 1190 1200 1210 1220 1230 1630 1640 1650 1660 1670 1680 pF1KE2 EEVCVDFNLITDDCFANSKKYKTRRAVMLKEMMEQNCAHSKKKLSRIILPDDSSEEENNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EEVCVDFNLITDDCFANSKKYKTRRAVMLKEMMEQNCAHSKKKLSRIILPDDSSEEENNV 1240 1250 1260 1270 1280 1290 1690 1700 1710 1720 1730 1740 pF1KE2 NDKRESNIAVNPSTVKKNKQQDHCLNSVPSGSSAQSKVRSTPRVNPLAKQSKQTSLNLKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NDKRESNIAVNPSTVKKNKQQDHCLNSVPSGSSAQSKVRSTPRVNPLAKQSKQTSLNLKD 1300 1310 1320 1330 1340 1350 1750 1760 1770 1780 1790 1800 pF1KE2 TISEVSDFKPQNHNEVQSTTPPFTTVDSQKDCRKFPVPQKDGSALEDSSTSGASCSKSRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TISEVSDFKPQNHNEVQSTTPPFTTVDSQKDCRKFPVPQKDGSALEDSSTSGASCSKSRP 1360 1370 1380 1390 1400 1410 1810 1820 1830 1840 1850 1860 pF1KE2 HLAGTHTSLRLAQEGKGTCILVGGHEITSGLEVISSLRAIHGLQVEVCPLNGCDYIVSNR ::::::::::: :::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HLAGTHTSLRLPQEGKGTCILVGGHEITSGLEVISSLRAIHGLQVEVCPLNGCDYIVSNR 1420 1430 1440 1450 1460 1470 1870 1880 1890 1900 1910 1920 pF1KE2 MVVERRSQSEMLNSVNKNKFIEQIQHLQSMFERICVIVEKDREKTGDTSRMFRRTKSYDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MVVERRSQSEMLNSVNKNKFIEQIQHLQSMFERICVIVEKDREKTGDTSRMFRRTKSYDS 1480 1490 1500 1510 1520 1530 1930 1940 1950 1960 1970 1980 pF1KE2 LLTTLIGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVNSNKSEALQFYLSIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLTTLIGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVNSNKSEALQFYLSIP 1540 1550 1560 1570 1580 1590 1990 2000 2010 2020 2030 2040 pF1KE2 NISYITALNMCHQFSSVKRMANSSLQEISMYAQVTHQKAEEIYRYIHYVFDIQMLPNDLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NISYITALNMCHQFSSVKRMANSSLQEISMYAQVTHQKAEEIYRYIHYVFDIQMLPNDLN 1600 1610 1620 1630 1640 1650 pF1KE2 QDRLKSDI :::::::: XP_016 QDRLKSDI >>XP_011535339 (OMIM: 189960,609644,614087) PREDICTED: F (1391 aa) initn: 5230 init1: 5230 opt: 9024 Z-score: 8028.6 bits: 1498.6 E(85289): 0 Smith-Waterman score: 9024; 99.2% identity (99.5% similar) in 1390 aa overlap (664-2048:3-1391) 640 650 660 670 680 690 pF1KE2 NPKLHKMFITHGVYEPEKPSRNLQRKSSIFSYRDGMRQSSLKKDWFLSEEEFKLWNRLYR ..: :::::::::::::::::::::::::: XP_011 MGTFR-GMRQSSLKKDWFLSEEEFKLWNRLYR 10 20 30 700 710 720 730 740 750 pF1KE2 LRDSDEIKEITLPQVQFSSLQNEENKPAQESTTGIHQLSLSEWRLWQDHPLPTHQVDHSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRDSDEIKEITLPQVQFSSLQNEENKPAQESTTGIHQLSLSEWRLWQDHPLPTHQVDHSD 40 50 60 70 80 90 760 770 780 790 800 810 pF1KE2 RCRHFIGLMQMIEGMRHEEGECSYELEVESYLQMEDVTSTFIAPRNESNNLASDTFITHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RCRHFIGLMQMIEGMRHEEGECSYELEVESYLQMEDVTSTFIAPRNESNNLASDTFITHK 100 110 120 130 140 150 820 830 840 850 860 870 pF1KE2 KSSFIKNINQGSSSSVIESDEECAEIVKQTHIKPTKIVSLKKKVSKEIKKDQLKKENNHG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KSSFIKNINQGSSSSVIESDEECAEIVKQTHIKPTKIVSLKKKVSKEIKKDQLKKENNHG 160 170 180 190 200 210 880 890 900 910 920 930 pF1KE2 IIDSLDNDRNSTVENIFQEDLPNDKRTSDTDEIAATCTINENVIKEPCVLLTECQFTNKS ::::.::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IIDSVDNDRNSTVENIFQEDLPNDKRTSDTDEIAATCTINENVIKEPCVLLTECQFTNKS 220 230 240 250 260 270 940 950 960 970 980 990 pF1KE2 TSSLAGNVLDSGYNSFNDEKSVSSNLFLPFEEELYIVRTDDQFYNCHSLTKEVLANVERF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TSSLAGNVLDSGYNSFNDEKSVSSNLFLPFEEELYIVRTDDQFYNCHSLTKEVLANVERF 280 290 300 310 320 330 1000 1010 1020 1030 1040 1050 pF1KE2 LSYSPPPLSGLSDLEYEIAKGTALENLLFLPCAEHLRSDKCTCLLSHSAVNSQQNLELNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSYSPPPLSGLSDLEYEIAKGTALENLLFLPCAEHLRSDKCTCLLSHSAVNSQQNLELNS 340 350 360 370 380 390 1060 1070 1080 1090 1100 1110 pF1KE2 LKCINYPSEKSCLYDIPNDNISDEPSLCDCDVHKHNQNENLVPNNRVQIHRSPAQNLVGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LKCINYPSEKSCLYDIPNDNISDEPSLCDCDVHKHNQNENLVPNNRVQIHRSPAQNLVGE 400 410 420 430 440 450 1120 1130 1140 1150 1160 1170 pF1KE2 NNHDVDNSDLPVLSTDQDESLLLFEDVNTEFDDVSLSPLNSKSESLPVSDKTAISETPLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NNHDVDNSDLPVLSTDQDESLLLFEDVNTEFDDVSLSPLNSKSESLPVSDKTAISETPLV 460 470 480 490 500 510 1180 1190 1200 1210 1220 1230 pF1KE2 SQFLISDELLLDNNSELQDQITRDANSFKSRDQRGVQEEKVKNHEDIFDCSRDLFSVTFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SQFLISDELLLDNNSELQDQITRDANSFKSRDQRGVQEEKVKNHEDIFDCSRDLFSVTFD 520 530 540 550 560 570 1240 1250 1260 1270 1280 1290 pF1KE2 LGFCSPDSDDEILEHTSDSNRPLDDLYGRYLEIKEISDANYVSNQALIPRDHSKNFTSGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGFCSPDSDDEILEHTSDSNRPLDDLYGRYLEIKEISDANYVSNQALIPRDHSKNFTSGT 580 590 600 610 620 630 1300 1310 1320 1330 1340 1350 pF1KE2 VIIPSNEDMQNPNYVHLPLSAAKNEELLSPGYSQFSLPVQKKVMSTPLSKSNTLNSFSKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VIIPSNEDMQNPNYVHLPLSAAKNEELLSPGYSQFSLPVQKKVMSTPLSKSNTLNSFSKI 640 650 660 670 680 690 1360 1370 1380 1390 1400 1410 pF1KE2 RKEILKTPDSSKEKVNLQRFKEALNSTFDYSEFSLEKSKSSGPMYLHKSCHSVEDGQLLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RKEILKTPDSSKEKVNLQRFKEALNSTFDYSEFSLEKSKSSGPMYLHKSCHSVEDGQLLT 700 710 720 730 740 750 1420 1430 1440 1450 1460 pF1KE2 SNESEDDEIFRRKVKRAKGNVLNSPEDQKNSEVDSPLHAVKKRRFPVNR-----SELSSS ::::::::::::::::::::::::::::::::::::::::::::::.:: :::::: XP_011 SNESEDDEIFRRKVKRAKGNVLNSPEDQKNSEVDSPLHAVKKRRFPINRVSKYQSELSSS 760 770 780 790 800 810 1470 1480 1490 1500 1510 1520 pF1KE2 DESENFPKPCSQLEDFKVCNGNARRGIKVPKRQSHLKHVARKFLDDEAELSEEDAEYVSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DESENFPKPCSQLEDFKVCNGNARRGIKVPKRQSHLKHVARKFLDDEAELSEEDAEYVSS 820 830 840 850 860 870 1530 1540 1550 1560 1570 1580 pF1KE2 DENDESENEQDSSLLDFLNDETQLSQAINDSEMRAIYMKSLRSPMMNNKYKMIHKTHKNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DENDESENEQDSSLLDFLNDETQLSQAINDSEMRAIYMKSLRSPMMNNKYKMIHKTHKNI 880 890 900 910 920 930 1590 1600 1610 1620 1630 1640 pF1KE2 NIFSQIPEQDETYLEDSFCVDEEESCKGQSSEEEVCVDFNLITDDCFANSKKYKTRRAVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NIFSQIPEQDETYLEDSFCVDEEESCKGQSSEEEVCVDFNLITDDCFANSKKYKTRRAVM 940 950 960 970 980 990 1650 1660 1670 1680 1690 1700 pF1KE2 LKEMMEQNCAHSKKKLSRIILPDDSSEEENNVNDKRESNIAVNPSTVKKNKQQDHCLNSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LKEMMEQNCAHSKKKLSRIILPDDSSEEENNVNDKRESNIAVNPSTVKKNKQQDHCLNSV 1000 1010 1020 1030 1040 1050 1710 1720 1730 1740 1750 1760 pF1KE2 PSGSSAQSKVRSTPRVNPLAKQSKQTSLNLKDTISEVSDFKPQNHNEVQSTTPPFTTVDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSGSSAQSKVRSTPRVNPLAKQSKQTSLNLKDTISEVSDFKPQNHNEVQSTTPPFTTVDS 1060 1070 1080 1090 1100 1110 1770 1780 1790 1800 1810 1820 pF1KE2 QKDCRKFPVPQKDGSALEDSSTSGASCSKSRPHLAGTHTSLRLAQEGKGTCILVGGHEIT ::::::::::::::::::::::::::::::::::::::::::: :::::::::::::::: XP_011 QKDCRKFPVPQKDGSALEDSSTSGASCSKSRPHLAGTHTSLRLPQEGKGTCILVGGHEIT 1120 1130 1140 1150 1160 1170 1830 1840 1850 1860 1870 1880 pF1KE2 SGLEVISSLRAIHGLQVEVCPLNGCDYIVSNRMVVERRSQSEMLNSVNKNKFIEQIQHLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SGLEVISSLRAIHGLQVEVCPLNGCDYIVSNRMVVERRSQSEMLNSVNKNKFIEQIQHLQ 1180 1190 1200 1210 1220 1230 1890 1900 1910 1920 1930 1940 pF1KE2 SMFERICVIVEKDREKTGDTSRMFRRTKSYDSLLTTLIGAGIRILFSSCQEETADLLKEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SMFERICVIVEKDREKTGDTSRMFRRTKSYDSLLTTLIGAGIRILFSSCQEETADLLKEL 1240 1250 1260 1270 1280 1290 1950 1960 1970 1980 1990 2000 pF1KE2 SLVEQRKNVGIHVPTVVNSNKSEALQFYLSIPNISYITALNMCHQFSSVKRMANSSLQEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLVEQRKNVGIHVPTVVNSNKSEALQFYLSIPNISYITALNMCHQFSSVKRMANSSLQEI 1300 1310 1320 1330 1340 1350 2010 2020 2030 2040 pF1KE2 SMYAQVTHQKAEEIYRYIHYVFDIQMLPNDLNQDRLKSDI :::::::::::::::::::::::::::::::::::::::: XP_011 SMYAQVTHQKAEEIYRYIHYVFDIQMLPNDLNQDRLKSDI 1360 1370 1380 1390 2048 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 19:46:07 2016 done: Sun Nov 6 19:46:10 2016 Total Scan time: 18.840 Total Display time: 1.320 Function used was FASTA [36.3.4 Apr, 2011]